ApoList – November 2022


Bcl-2 family proteins


Heightened apoptotic priming of vascular cells across tissues and life span predisposes them to cancer therapy-induced toxicities – Johan K. E. Spetz, Mary H. C. Florido, Cameron S. Fraser, Xingping Qin, Jonathan Choiniere, Stacey J. Yu, Rumani Singh, Max Friesen, Lee L. Rubin, Joe-Elie Salem, Javid J. Moslehi, Kristopher A. Sarosiek. https://www.science.org/doi/full/10.1126/sciadv.abn6579

A Mesenchymal Tumor Cell State Confers Increased Dependency on the BCL-XL Antiapoptotic Protein in Kidney Cancer – Treg Grubb, Smruthi Maganti, John Michael Krill-Burge, Cameron Fraser, Laura Stransky, Tomas Radivoyevitch, Kristopher A. Sarosiek, Francisca Vazquez, William G. Kaelin, Jr, Abhishek A. Chakraborty. https://aacrjournals.org/clincancerres/article-abstract/28/21/4689/709828

Modulation of Ca2+ signaling by antiapoptotic Bcl-2 versus Bcl-xL: From molecular mechanisms to relevance for cancer cell survival – Nicolas Rosa, Femke Speelman-Rooms, Jan B. Parys, Geert Bultynck. https://www.sciencedirect.com/science/article/abs/pii/S0304419X22001160

Reciprocal effects of mTOR inhibitors on pro-survival proteins dictate therapeutic responses in tuberous sclerosis complex – McNamara MC, Hosios AM, Torrence ME, Zhao T, Fraser C, Wilkinson M, Kwiatkowski DJ, Henske EP, Wu CL, Sarosiek KA, Valvezan AJ, Manning BD.. https://www.cell.com/iscience/fulltext/S2589-0042(22)01730-8

SRSF6 balances mitochondrial-driven innate immune outcomes through alternative splicing of BAX – Allison R Wagner, Chi G Weindel, Kelsi O West, Haley M Scott, Robert O Watson, Kristin L Patrick. https://elifesciences.org/articles/82244

Microfluidic-based dynamic BH3 profiling predicts anticancer treatment efficacy – Albert Manzano-Muñoz, José Yeste, María A. Ortega, Fernando Martín, Anna López, Jordi Rosell, Sandra Castro, César Serrano, Josep Samitier, Javier Ramón-Azcón and Joan Montero. https://www.nature.com/articles/s41698-022-00333-0


Death receptors and RIPK


cFLIP suppression and DR5 activation sensitize senescent cancer cells to senolysis – Liqin Wang, Haojie Jin, Fleur Jochems, Siying Wang, Cor Lieftink, Isabel Mora Martinez, Giulia De Conti, Finn Edwards, Rodrigo Leite de Oliveira, Arnout Schepers, Yangyang Zhou, Jiaojiao Zheng, Wei Wu, Xingling Zheng, Shengxian Yuan, Jing Ling, Kathy Jastrzebski, Matheus Dos Santos Dias, Ji-Ying Song, Patrick N. H. Celie, Hideo Yagita, Ming Yao, Weiping Zhou, Roderick L. Beijersbergen, Wenxin Qin and René Bernards. https://www.nature.com/articles/s43018-022-00462-2

An orally active, small-molecule TNF inhibitor that disrupts the homotrimerization interface improves inflammatory arthritis in mice – Nasir Javaid, Mahesh Chandra Patra, Da-Eun Cho, Maria Batool, Yoongeun Kim, Gwang Muk Choi, Moon Suk Kim, Dae-Hyun Hahm, Sangdun Choi. https://www.science.org/doi/abs/10.1126/scisignal.abi8713

SENP1 prevents steatohepatitis by suppressing RIPK1-driven apoptosis and inflammation – Lingjie Yan, Tao Zhang, Kai Wang, Zezhao Chen, Yuanxin Yang, Bing Shan, Qi Sun, Mengmeng Zhang, Yichi Zhang, Yedan Zhong, Nan Liu, Jinyang Gu and Daichao Xu. https://www.nature.com/articles/s41467-022-34993-0

Generative deep learning enables the discovery of a potent and selective RIPK1 inhibitor – Yueshan Li, Liting Zhang, Yifei Wang, Jun Zou, Ruicheng Yang, Xinling Luo, Chengyong Wu, Wei Yang, Chenyu Tian, Haixing Xu, Falu Wang, Xin Yang, Linli Li and Shengyong Yang. https://www.nature.com/articles/s41467-022-34692-w

Tyrosine phosphorylation regulates RIPK1 activity to limit cell death and inflammation – Hailin Tu, Weihang Xiong, Jie Zhang, Xueqiang Zhao and Xin Lin. https://www.nature.com/articles/s41467-022-34080-4


Caspases / Apaf-1


Caspase-8 inactivation drives autophagy-dependent inflammasome activation in myeloid cells – Yung-Hsuan Wu, Shu-Ting Mo, I-Ting Chen, Fu-Yi Hsieh, Shie-Liang Hsieh, Jinake Zhang, Ming-Zong Lai. https://www.science.org/doi/full/10.1126/sciadv.abn9912

Targeting the MITF/APAF-1 axis as salvage therapy for MAPK inhibitors in resistant melanoma – Pietro Carotenuto, Alessia Romano. . Anna Barbato. Paola Quadrano. Simona Brillante. Mariagrazia Volpe. Luigi Ferrante,  Roberta Tammaro, Manuela Morleo, Rossella De Cegli, Antonella Iuliano, Marialuisa Testa, Fabrizio Andreone,  Gennaro Ciliberto, Eduardo Clery, Giancarlo Troncone. Giuseppe Palma, Claudio Arra. Antonio Barbieri, Mariaelena Capone. Gabriele Madonna, Paolo A. Ascierto. Luisa Lanfrancone, Alessia Indrieri, Brunella Franco. https://www.cell.com/cell-reports/fulltext/S2211-1247(22)01466-8

Genuine selective caspase-2 inhibition with new irreversible small peptidomimetics – Elodie Bosc, Julie Anastasie, Feryel Soualmia, Pascale Coric, Ju Youn Kim, Lily Q. Wang, Gullen Lacin, Kaitao Zhao, Ronak Patel, Eric Duplus, Philippe Tixador, Andrew A. Sproul, Bernard Brugg, Michelle Reboud-Ravaux, Carol M. Troy, Michael L. Shelanski, Serge Bouaziz, Michael Karin, Chahrazade El Amri and Etienne D. Jacotot. https://www.nature.com/articles/s41419-022-05396-2

Neurovascular injury associated non-apoptotic endothelial caspase-9 and astroglial caspase-9 mediate inflammation and contrast sensitivity decline – Crystal Colón Ortiz, Albertine M. Neal, Maria I. Avrutsky, Monica Choi, Jade Smart, Jacqueline Lawson & Carol M. Troy. https://www.nature.com/articles/s41419-022-05387-3


Pyroptosis


Sublytic gasdermin-D pores captured in atomistic molecular simulations – Stefan L Schaefer, Gerhard Hummer. https://elifesciences.org/articles/81432

Nuclear translocation of Gasdermin D sensitizes colorectal cancer to chemotherapy in a pyroptosis-independent manner – Xiao Peng, Risi Na, Wenting Zhou, Xiaole Meng, Yunhai Yang, Shohreh Amini and Liwei Song. https://www.nature.com/articles/s41388-022-02503-7


Ferroptosis


Ferroptosis of tumour neutrophils causes immune suppression in cancer – Rina Kim, Ayumi Hashimoto, Nune Markosyan, Vladimir A. Tyurin, Yulia Y. Tyurina, Gozde Kar, Shuyu Fu, Mohit Sehgal, Laura Garcia-Gerique, Andrew Kossenkov, Bereket A. Gebregziabher, John W. Tobias, Kristin Hicks, Rebecca A. Halpin, Nevena Cvetesic, Hui Deng, Laxminarasimha Donthireddy, Andrew Greenberg, Brian Nam, Robert H. Vonderheide, Yulia Nefedova, Valerian E. Kagan and Dmitry I. Gabrilovich. https://www.nature.com/articles/s41586-022-05443-0

Doxorubicin causes ferroptosis and cardiotoxicity by intercalating into mitochondrial DNA and disrupting Alas1-dependent heme synthesis – Ko Abe, Masataka Ikeda, Tomomi Ide, Tomonori Tadokoro, Hiroko Deguchi Miyamoto, Shun Furusawa, Yoshitomo Tsutsui, Ryo Miyake, Kosei Ishimaru, Masatsugu Watanabe, Shouji Matsushima, Tomoko Koumura, Ken-ichi Yamada, Hirotaka Imai, Hiroyuki Tsutsui. https://www.science.org/doi/abs/10.1126/scisignal.abn8017


Miscellanous


Colon tumour cell death causes mTOR dependence by paracrine P2X4 stimulation – Mark Schmitt, Fatih Ceteci, Jalaj Gupta, Marina Pesic, Tim W. Böttger, Adele M. Nicolas, Kilian B. Kennel, Esther Engel, Matthias Schewe, Asude Callak Kirisözü, Valentina Petrocelli, Yasamin Dabiri, Julia Varga, Mallika Ramakrishnan, Madina Karimova, Andrea Ablasser, Toshiro Sato, Melek C. Arkan, Frederic J. de Sauvage and Florian R. Greten. https://www.nature.com/articles/s41586-022-05426-1


Reviews


Mitochondria and cell death-associated inflammation – Esmee Vringer and Stephen W. G. Tait. https://www.nature.com/articles/s41418-022-01094-w

T cell-mediated additive cytotoxicity – death by multiple bullets – Bettina Weigelin, Peter Friedl. https://www.cell.com/trends/cancer/fulltext/S2405-8033(22)00160-1

Extrinsic cell death pathway plasticity: a driver of clonal evolution in cancer? – Eric Seidel and Silvia von Karstedt. https://www.nature.com/articles/s41420-022-01251-7

Signaling pathways and defense mechanisms of ferroptosis – Jiao Liu, Rui Kang, Daolin Tang. https://febs.onlinelibrary.wiley.com/doi/full/10.1111/febs.16059

Balancing life and death: BCL‐2 family members at diverse ER–mitochondrial contact sites – Robert E. Means, Samuel G. Katz. https://febs.onlinelibrary.wiley.com/doi/full/10.1111/febs.16241


Comments


XL-ing at Induction of Apoptosis in Kidney Cancer through Inhibition of BCL-XL – Naitao Wang, A. Ari Hakimi, Yu Chen. https://aacrjournals.org/clincancerres/article-abstract/28/21/4600/709829

A cFLIP-flop switch for senolysis – Dorothy N. Y. Fan and Clemens A. Schmitt. https://www.nature.com/articles/s43018-022-00455-1

BH3-Mimetic Tolerance Is Driven by Sublethal Cytochrome c Release. https://aacrjournals.org/cancerdiscovery/article-abstract/12/11/OF7/709980

Glucose Metabolism in TAMs Promotes Metastasis and Drug Resistance. https://aacrjournals.org/cancerdiscovery/article-abstract/12/11/2495/710000

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