ApoList – December 2020

Bcl-2 family proteins


Inhibition of the anti-apoptotic protein MCL-1 severely suppresses human hematopoiesis – Sheila Bohler, Sehar Afreen, Juncal Fernandez-Orth, Eva-Maria Demmerath, Christian Molnar, Ying Wu, Julia Miriam Weiss, Venugopal Rao Mittapalli, Lukas Konstantinidis, Hagen Schmal, Mirjam Kunze, Miriam Erlacher. https://haematologica.org/article/view/haematol.2020.252130
 
BCL‐XL exerts a protective role against anemia caused by radiation‐induced kidney damage – Kerstin Brinkmann, Paul Waring, Stefan P Glaser, Verena Wimmer, Denny L Cottle, Ming Shen Tham, Duong Nhu, Lachlan Whitehead, Alex RD Delbridge, Guillaume Lessene, Ian M Smyth, Marco J Herold, Gemma L Kelly, Stephanie Grabow, Andreas Strasser. https://www.embopress.org/doi/abs/10.15252/embj.2020105561
 
BCL(X)L and BCL2 increase the metabolic fitness of breast cancer cells: a single-cell imaging study – Lucantoni F, Salvucci M, Düssmann H, Lindner AU, Lambrechts D, Prehn JHM. https://www.nature.com/articles/s41418-020-00683-x

The Heme-regulated Inhibitor Pathway Modulates Susceptibility of Poor Prognosis B-Lineage Acute Leukemia to BH3-Mimetics – Kaitlyn Hill Smith, Amit Budhraja, John Lynch, Kathryn Roberts, John C Panetta, Jon Patrick Connelly, Meghan E Turnis, Shondra M Pruett-Miller, John D Schuetz, Charles G. Mullighan and Joseph T Opferman. https://mcr.aacrjournals.org/content/early/2020/12/05/1541-7786.MCR-20-0586.abstract
 
MCL-1 is essential for survival but dispensable for metabolic fitness of FOXP3+ regulatory T cells – Charis E. Teh, Alissa K. Robbins, Darren C. Henstridge, Grant Dewson, Sarah T. Diepstraten, Gemma Kelly, Mark A. Febbraio, Sarah S. Gabriel, Lorraine A. O’Reilly, Andreas Strasser and Daniel H. D. Gray. https://www.nature.com/articles/s41418-020-0585-1
 
AZD4320, A Dual Inhibitor of Bcl-2 and Bcl-xL, Induces Tumor Regression in Hematologic Cancer Models without Dose-limiting Thrombocytopenia – Srividya B. Balachander, Steven W. Criscione, Kate F. Byth, Justin Cidado, Ammar Adam, Paula Lewis, Terry Macintyre, Shenghua Wen, Deborah Lawson, Kathleen Burke, Tristan Lubinski, Jeffrey W. Tyner, Stephen E. Kurtz, Shannon K. McWeeney, Jeffrey Varnes, R. Bruce Diebold, Thomas Gero, Stephanos Ioannidis, Edward J. Hennessy, William McCoull, Jamal C. Saeh, Areya Tabatabai, Omid Tavana, Nancy Su, Alwin Schuller, Mathew J. Garnett, Patricia Jaaks, Elizabeth A. Coker, Gareth P. Gregory, Andrea Newbold, Ricky W. Johnstone, Eric Gangl, Martin Wild, Michael Zinda, J. Paul Secrist, Barry R. Davies, Stephen E. Fawell and Francis D. Gibbons. https://clincancerres.aacrjournals.org/content/26/24/6535
 

Death receptors


A Fas-4-1BB fusion protein converts a death to a pro-survival signal and enhances T cell therapy – Shannon K. Oda; Kristin G. Anderson; Pranali Ravikumar; Patrick Bonson; Nicolas M. Garcia ; Cody M. Jenkins; Summer Zhuang; Andrew W. Daman; Edison Y. Chiu; Breanna M. Bates ; Philip D. Greenberg. https://rupress.org/jem/article/217/12/e20191166/152059/A-Fas-4-1BB-fusion-protein-converts-a-death-to-a
 
Site‐specific ubiquitination of the E3 ligase HOIP regulates apoptosis and immune signaling – Lilian M Fennell, Carlos Gomez Diaz, Luiza Deszcz, Anoop Kavirayani, David Hoffmann, Kota Yanagitani, Alexander Schleiffer, Karl Mechtler, Astrid Hagelkruys, Josef Penninger, Fumiyo Ikeda. https://www.embopress.org/doi/abs/10.15252/embj.2019103303
 
Ubiquitination of RIPK1 regulates its activation mediated by TNFR1 and TLRs signaling in distinct manners – Xingyan Li, Mengmeng Zhang, Xinyue Huang, Wei Liang, Ganquan Li, Xiaojuan Lu, Yanxia Li, Heling Pan, Linyu Shi, Hong Zhu, Lihui Qian, Bing Shan and Junying Yuan. https://www.nature.com/articles/s41467-020-19935-y
 

Necroptosis


Locking mixed-lineage kinase domain-like protein in its auto-inhibited state prevents necroptosis – Martin Rübbelke, Dennis Fiegen, Margit Bauer, Florian Binder, James Hamilton, Jim King, Sven Thamm, Herbert Nar and Markus Zeeb. https://www.pnas.org/content/117/52/33272.abstract?etoc
 
Discovery of a Potent RIPK3 Inhibitor for the Amelioration of Necroptosis-Associated Inflammatory Injury – Kaijiang Xia , Fang Zhu, Chengkui Yang , Shuwei Wu, Yu Lin, Haikuo Ma, Xiaoliang Yu , Cong Zhao , Yuting Ji , Wenxiang Ge, Jingrui Wang , Yayun Du , Wei Zhang , Tao Yang , Xiaohu Zhang and Sudan He. https://www.frontiersin.org/articles/10.3389/fcell.2020.606119/full
 

Ferroptosis (or lipid synthesis)


Ferroptotic damage promotes pancreatic tumorigenesis through a TMEM173/STING-dependent DNA sensor pathway – Enyong Dai, Leng Han, Jiao Liu, Yangchun Xie, Herbert J. Zeh, Rui Kang, Lulu Bai and Daolin Tang. https://www.nature.com/articles/s41467-020-20154-8
 
Oncogenic activation of PI3K-AKT-mTOR signaling suppresses ferroptosis via SREBP-mediated lipogenesis – Junmei Yi, Jiajun Zhu, Jiao Wu, Craig B. Thompson, and Xuejun Jiang. https://www.pnas.org/content/117/49/31189.abstract?etoc
 
HCAR1/MCT1 Regulates Tumor Ferroptosis through the Lactate-Mediated AMPK-SCD1 Activity and Its Therapeutic Implications – Youbo Zhao, Menghuan Li, Xuemei Yao, Yang Fei, Zhenghong Lin, Zhengguo Li, Kaiyong Cai, Yanli Zhao, Zhong Luo. https://www.cell.com/cell-reports/fulltext/S2211-1247(20)31476-5 
 
3D Culture Models with CRISPR Screens Reveal Hyperactive NRF2 as a Prerequisite for Spheroid Formation via Regulation of Proliferation and Ferroptosis – Nobuaki Takahashi, Patricia Cho, Laura M. Selfors, Hendrik J. Kuiken, Roma Kaul, Takuro Fujiwara, Isaac S. Harris, Tian Zhang, Steven P. Gygi, Joan S. Brugge. https://www.cell.com/molecular-cell/fulltext/S1097-2765(20)30693-6
 

Miscellanous


The E3 ligase UBR2 regulates cell death under caspase deficiency via Erk/MAPK pathway – Elodie Villa, Rachel Paul, Ophélie Meynet, Sophie Volturo, Guillaume Pinna and Jean-Ehrland Ricci. https://www.nature.com/articles/s41419-020-03258-3
 
Apoptosis in the fetal testis eliminates developmentally defective germ cell clones – Daniel H. Nguyen, Bikem Soygur, Su-Ping Peng, Safia Malki, Guang Hu and Diana J. Laird. https://www.nature.com/articles/s41556-020-00603-8
 
Intracellular cathepsin C levels determine sensitivity of cells to leucyl‐leucine methyl ester‐triggered apoptosis – Nežka Kavčič, Miha Butinar, Barbara Sobotič, Maruša Hafner Česen, Ana Petelin, Lea Bojić, Tina Zavašnik Bergant, Andreja Bratovš, Thomas Reinheckel, Boris Turk. https://febs.onlinelibrary.wiley.com/doi/abs/10.1111/febs.15326
 
Plasma exosomal miR-375-3p regulates mitochondria-dependent keratinocyte apoptosis by targeting XIAP in severe drug-induced skin reactions – Chen Zhang , ZhenLai Zhu, JiXin Gao, LuTing Yang, ErLe Dang, Hui Fang, Shuai Shao, ShaoLong Zhang, ChunYing Xiao, Xu Yuan, Wei Li, Riichiro Abe, HongJiang Qiao, Gang Wang, Meng Fu. https://stm.sciencemag.org/content/12/574/eaaw6142
 

Reviews


Caspase-2 Substrates: To Apoptosis, Cell Cycle Control, and Beyond – Alexandra N. Brown-Suedel and Lisa Bouchier-Hayes. https://www.frontiersin.org/articles/10.3389/fcell.2020.610022/full
 
Pore formation in regulated cell death – Hector Flores‐Romero, Uris Ros, Ana J Garcia‐Saez. https://www.embopress.org/doi/full/10.15252/embj.2020105753
 
The Metabolic Underpinnings of Ferroptosis – Jiashuo Zheng, Marcus Conrad. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(20)30544-1
 

Comments


Mitochondria in Their Prime Drive Venetoclax Response in Acute Myeloid Leukemia – Mette C. Kriegbaum, Krister Wennerberg. https://www.cell.com/cancer-cell/fulltext/S1535-6108(20)30549-3?

Targeting MCL1 to induce mitophagy is a potential therapeutic strategy for Alzheimer disease – 
Xufeng Cen , Xiaoyan Xu and Hongguang Xia. https://www.tandfonline.com/doi/full/10.1080/15548627.2020.1860542

ApoList – November 2020


Bcl-2 family proteins


Reduced Mitochondrial Apoptotic Priming Drives Resistance to BH3 Mimetics in Acute Myeloid Leukemia – Shruti Bhatt, Marissa S. Pioso, Elyse Anne Olesinski, Binyam Yilma Jeremy A. Ryan, Thelma Mashaka, Buon Leutz, Sophia Adamia, Haoling Zhu, Yanan Kuang, Abhishek Mogili, Abner J. Louissaint, Stephan R. Bohl, Annette S. Kim, Anita K. Mehta, Sneha Sanghavi, Youzhen Wang, Erick Morris, Ensar Halilovic, Cloud P. Paweletz, David M. Weinstock, Jacqueline S. Garcia, Anthony Letai. https://www.sciencedirect.com/science/article/pii/S1535610820305419

Mcl-1 and Bok transmembrane domains: Unexpected players in the modulation of apoptosis – Estefanía Lucendo,  Mónica Sancho,  Fabio Lolicato,  Matti Javanainen,  Waldemar Kulig, Diego Leiva, Gerard Duart, Vicente Andreu-Fernández,  Ismael Mingarro and Mar Orzáez. https://www.pnas.org/content/early/2020/10/21/2008885117.abstract

Viral Bcl2s’ transmembrane domain interact with host Bcl2 proteins to control cellular apoptosis – Maria Jesús García-Murria, Gerard Duart, Brayan Grau, Elisabet Diaz-Beneitez, Dolores Rodríguez, Ismael Mingarro and Luis Martínez-Gil. https://www.nature.com/articles/s41467-020-19881-9

ELP-dependent expression of MCL1 promotes resistance to EGFR inhibition in triple-negative breast cancer cells – Peter Cruz-Gordillo, Megan E. Honeywell, Nicholas W. Harper, Thomas Leete, Michael J. Lee. https://stke.sciencemag.org/content/13/658/eabb9820

MCL1 binds and negatively regulates the transcriptional function of tumor suppressor p73 – Hayley Widden, Aneta Kaczmarczyk, Ashok Subedi, Robert H. Whitaker and William J. Placzek. https://www.nature.com/articles/s41419-020-03068-7

Mitofusin 2 but not mitofusin 1 mediates Bcl-XL-induced mitochondrial aggregation – Mengyan Du, Si Yu, Wenhua Su, Mengxin Zhao, Fangfang Yang, Yangpei Liu, Zihao Mai, Yong Wang, Xiaoping Wang and Tongsheng Chen. http://jcs.biologists.org/content/133/20/jcs245001?etoc

Pharmacological targeting of MCL-1 promotes mitophagy and improves disease pathologies in an Alzheimer’s disease mouse model – Xufeng Cen, Yanying Chen, Xiaoyan Xu, Ronghai Wu, Fusheng He, Qingwei Zhao, Qiming Sun, Cong Yi, Jie Wu, Ayaz Najafov and Hongguang Xia. https://www.nature.com/articles/s41467-020-19547-6

BCL-XL is an actionable target for treatment of malignant pleural mesothelioma – Surein Arulananda, Megan O’Brien, Marco Evangelista, Tiffany J. Harris, Nikita S. Steinohrt, Laura J. Jenkins, Marzena Walkiewicz, Robert J. J. O’Donoghue, Ashleigh R. Poh, Bibhusal Thapa, David S. Williams, Trishe Leong, John M. Mariadason, Xia Li, Jonathan Cebon, Erinna F. Lee, Thomas John and W. Douglas Fairlie. https://www.nature.com/articles/s41420-020-00348-1

Taxane-induced Attenuation of the CXCR2/BCL-2 Axis Sensitizes Prostate Cancer to Platinum-based Treatment – Vicenç Ruiz de Porras,  Xieng C. Wang, Luis Palomero, Mercedes Marin-Aguilera, Carme Solé-Blanch, Alberto Indacochea, Natalia Jimenez, Sara Bystrup, Martin Bakht, Vincenza Conteduca, Josep M. Piulats, Oscar Buisan, José F. Suarez, Juan Carlos Pardo, Elena Castro, David Olmos, Himisha Beltran, Begoña Mellado, Eva Martinez-Balibrea, Albert Font, Alvaro Aytes. https://www.europeanurology.com/article/S0302-2838(20)30778-8/fulltext#.X6CQKHJdwUM

Serine-70 phosphorylated Bcl-2 prevents oxidative stress-induced DNA damage by modulating the mitochondrial redox metabolism – Stephen Jun Fei Chong, Kartini Iskandar, Jolin Xiao Hui Lai, Jianhua Qu, Deepika Raman, Rebecca Valentin, Charles Herbaux, Mary Collins, Ivan Cherh Chiet Low, Thomas Loh, Matthew Davids, Shazib Pervaiz. https://academic.oup.com/nar/advance-article/doi/10.1093/nar/gkaa1110/6007660

LncRNA LHFPL3-AS1 contributes to tumorigenesis of melanoma stem cells via the miR-181a-5p/BCL2 pathway – Song Zhang, Haitao Wan and Xiaobo Zhang. https://www.nature.com/articles/s41419-020-03141-1


Death receptors


Inhibition of Glutamine Utilization Synergizes with Immune Checkpoint Inhibitor to Promote Antitumor Immunity – Jun-Kyu Byun, Mihyang Park, Seunghyeong Lee, Jae Won Yun, Jaebon Lee, Jae Sun Kim, Sung Jin Cho, Hui-Jeon Jeon, In-Kyu Lee, Yeon-Kyung Choi, Keun-Gyu Park. https://www.cell.com/molecular-cell/fulltext/S1097-2765(20)30722-X

Tumor Necrosis Factor Receptor-1 (p55) Deficiency Attenuates Tumor Growth and Intratumoral Angiogenesis and Stimulates CD8+ T Cell Function in Melanoma – Rodriguez YI, Campos LE, Castro MG, Bannoud N, Blidner AG, Filippa VP, Croci DO, Rabinovich GA, Alvarez SE. https://www.mdpi.com/2073-4409/9/11/2469


Caspases and IAPs


Caspase-8-dependent gasdermin D cleavage promotes antimicrobial defense but confers susceptibility to TNF-induced lethality – Benjamin Demarco , James P. Grayczyk, Elisabet Bjanes, Didier Le Roy, Wulf Tonnus, Charles-Antoine Assenmacher, Enrico Radaelli, Timothée Fettrelet, Vanessa Mack, Andreas Linkermann, Thierry Roger, Igor E. Brodsky, Kaiwen W. Chen, Petr Broz. https://advances.sciencemag.org/content/6/47/eabc3465

A regulatory region on RIPK2 is required for XIAP binding and NOD signaling activity – Valentin J Heim, Laura F Dagley, Che A Stafford, Fynn M Hansen, Elise Clayer, Aleksandra Bankovacki, Andrew I Webb, Isabelle S Lucet, John Silke, Ueli Nachbur. https://www.embopress.org/doi/abs/10.15252/embr.202050400

Molecular subtype-specific responses of colon cancer cells to the SMAC mimetic Birinapant – Michael Fichtner, Emir Bozkurt, Manuela Salvucci, Christopher McCann, Katherine A. McAllister, Luise Halang, Heiko Düssmann, Sinéad Kinsella, Nyree Crawford, Tamas Sessler, Daniel B. Longley and Jochen H. M. Prehn. https://www.nature.com/articles/s41419-020-03232-z


Necroptosis


Necroptosis restricts influenza A virus as a stand-alone cell death mechanism – Maria Shubina; Bart Tummers; David F. Boyd; Ting Zhang ; Chaoran Yin; Avishekh Gautam; Xi-zhi J. Guo; Diego A. Rodriguez; William J. Kaiser ; Peter Vogel; Douglas R. Green; Paul G. Thomas; Siddharth Balachandran. https://rupress.org/jem/article/217/11/e20191259/152023


Ferroptosis


Vaccination with early ferroptotic cancer cells induces efficient antitumor immunity – Iuliia Efimova, Elena Catanzaro, Louis Van der Meeren, Victoria D Turubanova, Hamida Hammad6, Tatiana A Mishchenko, Maria V Vedunova, Carmela Fimognari, Claus Bachert8, Frauke Coppieters, Steve Lefever, Andre G Skirtach, Olga Krysko and Dmitri V Krysko. https://jitc.bmj.com/content/8/2/e001369

Targeted reduction of cholesterol uptake in cholesterol-addicted lymphoma cells blocks turnover of oxidized lipids to cause ferroptosis – Jonathan S. Rink, Adam Lin, Kaylin M. McMahon, Andrea E Calvert, Shuo Yang, Tim Taxter, Jonathan Moreira, Amy Chadburn, Amir Behdad, Reem Karmali, C. Shad Thaxton and Leo I Gordon. http://www.jbc.org/content/early/2020/11/18/jbc.RA120.014888.abstract


Other forms of cell death


Ionizing radiation results in a mixture of cellular outcomes including mitotic catastrophe, senescence, methuosis, and iron-dependent cell death – Sandy Adjemian, Teodora Oltean, Sofie Martens, Bartosz Wiernicki, Vera Goossens, Tom Vanden Berghe, Benjamin Cappe, Maria Ladik, Franck B. Riquet, Liesbeth Heyndrickx, Jolien Bridelance, Marnik Vuylsteke, Katrien Vandecasteele and Peter Vandenabeele. https://www.nature.com/articles/s41419-020-03209-y


Miscellanous


Akt1 and dCIZ1 promote cell survival from apoptotic caspase activation during regeneration and oncogenic overgrowth – Gongping Sun, Xun Austin Ding, Yewubdar Argaw, Xiaoran Guo and Denise J. Montell. https://www.nature.com/articles/s41467-020-19068-2

Direct Tumor Killing and Immunotherapy through Anti-SerpinB9 Therapy – Liwei Jiang, Yi-Jun Wang, Jing Zhao, Mayuko Uehara, Qingming Hou, Vivek Kasinath, Takaharu Ichimura, Naima Banouni, Li Dai, Xiaofei Li, Dale L. Greiner, Leonard D. Shultz, Xiaolong Zhang, Zhen-Yu Jim Sun, Ian Curtin, Nicholas E. Vangos, Zoe C. Yeoh, Ezekiel A. Geffken, Hyuk-Soo Seo, Ze-Xian Liu, Gregory J. Heffron, Khalid Shah, Sirano Dhe-Paganon, Reza Abdi. https://www.cell.com/cell/fulltext/S0092-8674(20)31452-5

p53 deficiency triggers dysregulation of diverse cellular processes in physiological oxygen – Liz J. Valente; Amy Tarangelo; Albert Mao Li ; Marwan Naciri; Nitin Raj; Anthony M. Boutelle; Yang Li; Stephano Spano Mello ; Kathryn Bieging-Rolett; Ralph J. DeBerardinis; Jiangbin Ye; Scott J. Dixon; Laura D. Attardi. https://rupress.org/jcb/article/219/11/e201908212/152074

The 89-kDa PARP1 cleavage fragment serves as a cytoplasmic PAR carrier to induce AIF-mediated apoptosis – Masato Mashimo, Mayu Onishi, Arina Uno, Akari Tanimichi, Akari Nobeyama, Mana Mori, Sayaka Yamada, Shigeru Negi, Xiangning Bu, Jiro Kato, Joel Moss, Noriko Sanada, Ryoichi Kizu and Takeshi Fujii. http://www.jbc.org/content/early/2020/11/09/jbc.RA120.014479.abstract


Reviews


Targeting Bcl-2 Proteins in Acute Myeloid Leukemia – Yunxiong Wei, Yaqing Cao, Rui Sun, Lin Cheng, Xia Xiong, Xin Jin, Xiaoyuan He, Wenyi Lu, and Mingfeng Zhao. https://www.frontiersin.org/articles/10.3389/fonc.2020.584974/full

Interplay between caspase, Yes-associated protein, and mechanics: A possible switch between life and death? – Jessica Evangeline Tan Kabigting, Yusuke Toyama. https://www.sciencedirect.com/science/article/pii/S0955067420301459

Venetoclax-Based Combinations in Acute Myeloid Leukemia: Current Evidence and Future Directions – Bachar Samra, Marina Konopleva, Alessandro Isidori, Naval Daver, and Courtney DiNardo. https://www.frontiersin.org/articles/10.3389/fonc.2020.562558/full

The function and mechanism of ferroptosis in cancer – Ying Wang, Zihao Wei, Keran Pan, Jing Li, Qianming Chen. https://link.springer.com/article/10.1007/s10495-020-01638-w

TRAIL of Hope Meeting Resistance in Cancer – David Deng, Khalid Shah. https://www.cell.com/trends/cancer/fulltext/S2405-8033(20)30190-4

Detection of immunogenic cell death and its relevance for cancer therapy – Jitka Fucikova, Oliver Kepp, Lenka Kasikova, Giulia Petroni, Takahiro Yamazaki, Peng Liu, Liwei Zhao, Radek Spisek, Guido Kroemer and Lorenzo Galluzzi. https://www.nature.com/articles/s41419-020-03221-2

The caspase-3/GSDME signal pathway as a switch between apoptosis and pyroptosis in cancer – Mingxia Jiang, Ling Qi, Lisha Li and Yanjing Li. https://www.nature.com/articles/s41420-020-00349-0

Targeting BCL-2 in B-cell malignancies and overcoming therapeutic resistance – Isha Kapoor, Juraj Bodo, Brian T. Hill, Eric D. Hsi and Alexandru Almasan. https://www.nature.com/articles/s41419-020-03144-y


Comments


Caspase 2 and p53 Reunited in Tumor Control – Giulia Petroni, Ilio Vitale, Lorenzo Galluzzi. https://www.cell.com/trends/cell-biology/fulltext/S0962-8924(20)30168-9

Caspase-8 protein cuts a brake on immune defences – Igor E. Brodsky. https://www.nature.com/articles/d41586-020-02994-y

The interplay between apoptosis and ferroptosis mediated by ER stress – Go J. Yoshida. https://link.springer.com/article/10.1007/s10495-020-01641-1

ApoList – October 2020


Bcl-2 family proteins


Mcl-1 and Bok transmembrane domains: Unexpected players in the modulation of apoptosis – Estefanía Lucendo, Mónica Sancho, Fabio Lolicato, Matti Javanainen, Waldemar Kulig, Diego Leiva, Gerard Duart, Vicente Andreu-Fernández, Ismael Mingarro, and Mar Orzáez. https://www.pnas.org/content/early/2020/10/21/2008885117.abstract

Ancient and conserved functional interplay between Bcl-2 family proteins in the mitochondrial pathway of apoptosis – Nikolay Popgeorgiev, Jaison D Sa, Lea Jabbour, Suresh Banjara, Trang Thi Minh Nguyen, Aida Akhavan-E-Sabet, Rudy Gadet, Nikola Ralchev, Stéphen Manon, Mark G. Hinds, Hans-Jürgen Osigus, Bernd Schierwater, Patrick O. Humbert, Ruth Rimokh, Germain Gillet, Marc Kvansakul. https://advances.sciencemag.org/content/6/40/eabc4149

Identification of BCL-XL as highly active survival factor and promising therapeutic target in colorectal cancer – Anna-Lena Scherr, Andreas Mock, Georg Gdynia, Nathalie Schmitt, Christoph E. Heilig, Felix Korell, Praveen Rhadakrishnan, Paula Hoffmeister, Klaus H. Metzeler, Klaus Schulze-Osthoff, Anna L. Illert, Melanie Boerries, Jörg Trojan, Oliver Waidmann, Johanna Falkenhorst, Jens Siveke, Philipp J. Jost, Michael Bitzer, Nisar P. Malek, Loredana Vecchione, Ivan Jelas, Benedikt Brors, Hanno Glimm, Albrecht Stenzinger, Svetlana P. Grekova, Tobias Gehrig, Henning Schulze-Bergkamen, Dirk Jäger, Peter Schirmacher, Mathias Heikenwalder, Benjamin Goeppert, Martin Schneider, Stefan Fröhling and Bruno C. Köhler. https://www.nature.com/articles/s41419-020-03092-7

BioID-based proteomic analysis of the Bid interactome identifies novel proteins involved in cell-cycle-dependent apoptotic priming – Robert Pedley, Louise E. King, Venkatesh Mallikarjun, Pengbo Wang, Joe Swift, Keith Brennan and Andrew P. Gilmore. https://www.nature.com/articles/s41419-020-03091-8

Leukemia Cell of Origin Influences Apoptotic Priming and Sensitivity to LSD1 Inhibition – Sheng F. Cai, S. Haihua Chu, Aaron D. Goldberg, Salma Parvin, Richard P. Koche, Jacob L. Glass, Eytan M. Stein, Martin S. Tallman, Filiz Sen, Christopher A. Famulare, Monica Cusan, Chun-Hao Huang, Chun-Wei Chen, Lihua Zou, Keith B. Cordner, Nicole L. DelGaudio, Vidushi Durani, Mitali Kini, Madison Rex, Helen S. Tian, Johannes Zuber, Timour Baslan, Scott W. Lowe, Hugh Y. Rienhoff Jr, Anthony Letai, Ross L. Levine and Scott A. Armstrong. https://cancerdiscovery.aacrjournals.org/content/10/10/1500

Methylation of HSP70 Orchestrates Its Binding to and Stabilization of BCL2 mRNA and Renders Pancreatic Cancer Cells Resistant to Therapeutics – Liang Wang, Zhiliang Jia, Dacheng Xie, Tiansuo Zhao, Zhi Tan, Shuxing Zhang, Fanyang Kong, Daoyan Wei and Keping Xie. https://cancerres.aacrjournals.org/content/80/20/4500

BH3 mimetics selectively eliminate chemotherapy-induced senescent cells and improve response in TP53 wild-type breast cancer – Ashkan Shahbandi, Sonia G. Rao, Ashlyn Y. Anderson, Wesley D. Frey, Joy O. Olayiwola, Nathan A. Ungerleider and James G. Jackson. https://www.nature.com/articles/s41418-020-0564-6


Death receptors


Human Cancers Express TRAILshort, a Dominant Negative TRAIL Splice Variant, Which Impairs Immune Effector Cell Killing of Tumor Cells – Fatma Aboulnasr, Ashton Krogman, Rondell P. Graham, Nathan W. Cummins, Anisha Misra, Enrique Garcia-Rivera, Jeff R. Anderson, Sekar Natesampillai, Nicole Kogan, Murali Aravamudan, Zilin Nie, Thomas D.Y. Chung, Richard Buick, Andrew L. Feldman, Rebecca L. King, Anne J. Novak, Stephen M. Ansell, Saad Kenderian and Andrew D. Badley. https://clincancerres.aacrjournals.org/content/26/21/5759

TRAIL receptor agonists convert the response of breast cancer cells to ONC201 from anti-proliferative to apoptotic – Marie D. Ralff, Aakash Jhaveri, Jocelyn E. Ray, Lanlan Zhou, Avital Lev, Kerry S. Campbell, David T. Dicker, Eric A. Ross,  and  Wafik S. El-Deiry. https://www.oncotarget.com/article/27773/text/

RALB GTPase: a critical regulator of DR5 expression and TRAIL sensitivity in KRAS mutant colorectal cancer – Hajrah Khawaja, Andrew Campbell, Jamie Z. Roberts, Arman Javadi, Paul O’Reilly, Darragh McArt, Wendy L. Allen, Joanna Majkut, Markus Rehm, Alberto Bardelli, Federica Di Nicolantonio, Christopher J. Scott, Richard Kennedy, Nicolas Vitale, Timothy Harrison, Owen J. Sansom, Daniel B. Longley, Emma Evergren and Sandra Van Schaeybroeck. https://www.nature.com/articles/s41419-020-03131-3

Stress-induced TRAILR2 expression overcomes TRAIL resistance in cancer cell spheroids – Daniela Stöhr, Jens O. Schmid, Tobias B. Beigl, Alexandra Mack, Daniela S. Maichl, Kai Cao, Beate Budai, Gavin Fullstone, Roland E. Kontermann, Thomas E. Mürdter, Stephen W. G. Tait, Cathrin Hagenlocher, Nadine Pollak, Peter Scheurich and Markus Rehm. https://www.nature.com/articles/s41418-020-0559-3


Caspases and IAPs


Integration of innate immune signalling by caspase-8 cleavage of N4BP1 – Alexander D. Gitlin, Klaus Heger, Alexander F. Schubert, Rohit Reja, Donghong Yan, Victoria C. Pham, Eric Suto, Juan Zhang, Youngsu C. Kwon, Emily C. Freund, Jing Kang, Anna Pham, Roger Caothien, Natasha Bacarro, Trent Hinkle, Min Xu, Brent S. McKenzie, Benjamin Haley, Wyne P. Lee, Jennie R. Lill, Merone Roose-Girma, Monika Dohse, Joshua D. Webster, Kim Newton and Vishva M. Dixit. https://www.nature.com/articles/s41586-020-2796-5

A Non-canonical PDK1-RSK Signal Diminishes Pro-caspase-8-Mediated Necroptosis Blockade – Zhang-Hua Yang, Xiao-Nan Wu, Peng He, Xuekun Wang, Jianfeng Wu, Tingting Ai, Chuan-Qi Zhong, Xiurong Wu, Yu Cong, Rongfeng Zhu, Hongda Li, Zhi-Yu Cai, Wei Mo, Jiahuai Han. https://www.cell.com/molecular-cell/fulltext/S1097-2765(20)30612-2

The Inhibitor of Apoptosis Protein Livin Confers Resistance to Fas-Mediated Immune Cytotoxicity in Refractory Lymphoma – Eiji Sugihara, Norisato Hashimoto, Satoru Osuka, Takatsune Shimizu, Sayaka Ueno, Shogo Okazaki, Tomonori Yaguchi, Yutaka Kawakami, Kenjiro Kosaki, Taka-Aki Sato, Shinichiro Okamoto and Hideyuki Saya. https://cancerres.aacrjournals.org/content/80/20/4439


Necroptosis


Beclin 1 functions as a negative modulator of MLKL oligomerisation by integrating into the necrosome complex – Jinho Seo, Daehyeon Seong, Young Woo Nam, Chi Hyun Hwang, Seung Ri Lee, Choong-Sil Lee, Young Jin, Han-Woong Lee, Doo-Byoung Oh, Peter Vandenabeele and Jaewhan Song. https://www.nature.com/articles/s41418-020-0561-9

RIPK1 gene variants associate with obesity in humans and can be therapeutically silenced to reduce obesity in mice – Denuja Karunakaran, Adam W. Turner, Anne-Claire Duchez, Sebastien Soubeyrand, Adil Rasheed, David Smyth, David P. Cook, Majid Nikpay, Joshua W. Kandiah, Calvin Pan, Michele Geoffrion, Richard Lee, Ludovic Boytard, Hailey Wyatt, My-Anh Nguyen, Paulina Lau, Markku Laakso, Bhama Ramkhelawon, Marcus Alvarez, Kirsi H. Pietiläinen, Päivi Pajukanta, Barbara C. Vanderhyden, Peter Liu, Scott B. Berger, Peter J. Gough, John Bertin, Mary-Ellen Harper, Aldons J. Lusis, Ruth McPherson and Katey J. Rayner. https://www.nature.com/articles/s42255-020-00279-2

ZBP1 promotes fungi-induced inflammasome activation and pyroptosis, apoptosis, and necroptosis (PANoptosis) – Balaji Banoth, Shraddha Tuladhar, Rajendra Karki, Bhesh Raj Sharma, Benoit Briard, Sannula Kesavardhana, Amanda Burton and Thirumala-Devi Kanneganti. http://www.jbc.org/content/early/2020/10/27/jbc.RA120.015924.abstract


Pyroptosis


PD-L1-mediated gasdermin C expression switches apoptosis to pyroptosis in cancer cells and facilitates tumour necrosis – Junwei Hou, Rongce Zhao, Weiya Xia, Chiung-Wen Chang, Yun You, Jung-Mao Hsu, Lei Nie, Yeh Chen, Yu-Chuan Wang, Chunxiao Liu, Wei-Jan Wang, Yun Wu, Baozhen Ke, Jennifer L. Hsu, Kebin Huang, Zu Ye, Yi Yang, Xianghou Xia, Yintao Li, Chia-Wei Li, Bin Shao, John A. Tainer and Mien-Chie Hung. https://www.nature.com/articles/s41556-020-0575-z

CARD8 inflammasome activation triggers pyroptosis in human T cells – Andreas Linder, Stefan Bauernfried, Yiming Cheng, Manuel Albanese, Christophe Jung, Oliver T Keppler, Veit Hornung. https://www.embopress.org/doi/full/10.15252/embj.2020105071


Ferroptosis


Excessive phospholipid peroxidation distinguishes ferroptosis from other cell death modes including pyroptosis – Bartosz Wiernicki, Hanne Dubois, Yulia Y. Tyurina, Behrouz Hassannia, Hülya Bayir, Valerian E. Kagan, Peter Vandenabeele, Andy Wullaert and Tom Vanden Berghe. https://www.nature.com/articles/s41419-020-03118-0

Neutrophil-induced ferroptosis promotes tumor necrosis in glioblastoma progression – Patricia P. Yee, Yiju Wei, Soo-Yeon Kim, Tong Lu, Stephen Y. Chih, Cynthia Lawson, Miaolu Tang, Zhijun Liu, Benjamin Anderson, Krishnamoorthy Thamburaj, Megan M. Young, Dawit G. Aregawi, Michael J. Glantz, Brad E. Zacharia, Charles S. Specht, Hong-Gang Wang and Wei Li. https://www.nature.com/articles/s41467-020-19193-y

Dynasore Blocks Ferroptosis through Combined Modulation of Iron Uptake and Inhibition of Mitochondrial Respiration – Laura Prieto Clemente, Malena Rabenau, Stephan Tang, Josefina Stanka, Eileen Cors, Jenny Stroh, Carsten Culmsee  and Silvia von Karstedt. https://www.mdpi.com/2073-4409/9/10/2259

BAX-dependent mitochondrial pathway mediates the crosstalk between ferroptosis and apoptosis – Young-Sun Lee, Kalishwaralal Kalimuthu, Yong Seok Park, Xu Luo, M. Haroon A. Choudry, David L. Bartlett and Yong J. Lee. https://link.springer.com/article/10.1007/s10495-020-01627-z

Relieving ferroptosis may partially reverse neurodegeneration of the auditory cortex – Xi Chen, Dan Li, Hai‐Ying Sun, Wen‐Wen Wang, Han Wu, Wen Kong, Wei‐Jia Kong. https://febs.onlinelibrary.wiley.com/doi/abs/10.1111/febs.15266


Miscellanous


Nox4 regulates InsP3 receptor‐dependent Ca2+ release into mitochondria to promote cell survival – Matteo Beretta, Celio XC Santos, Chris Molenaar, Anne D Hafstad, Chris CJ Miller, Aram Revazian, Kai Betteridge, Katrin Schröder, Katrin Streckfuß‐Bömeke, James H Doroshow, Roland A Fleck, Tsung‐Ping Su, Vsevolod V Belousov, Maddy Parsons, Ajay M Shah. https://www.embopress.org/doi/full/10.15252/embj.2019103530

Mammalian lipid droplets are innate immune hubs integrating cell metabolism and host defense – Marta Bosch, Miguel Sánchez-Álvarez, Alba Fajardo, Ronan Kapetanovic, Bernhard Steiner, Filipe Dutra, Luciana Moreira, Juan Antonio López, Rocío Campo, Montserrat Marí, Frederic Morales-Paytuví, Olivia Tort, Albert Gubern, Rachel M. Templin, James E. B. Curson, Nick Martel, Cristina Català, Francisco Lozano, Francesc Tebar, Carlos Enrich, Jesús Vázquez, Miguel A. Del Pozo, Matthew J. Sweet, Patricia T. Bozza, Steven P. Gross, Robert G. Parton, Albert Pol. https://science.sciencemag.org/content/370/6514/eaay8085

NETosis Occurs Independently of Neutrophil Serine Proteases – Paulina Kasperkiewicz, Anne Hempel, Tomasz Janiszewski, Sonia Kolt, Scott J Snipas, Marcin Drag and Guy S Salvesen. http://www.jbc.org/content/early/2020/10/15/jbc.RA120.015682.abstract

Cytokine regulation of apoptosis-induced apoptosis and apoptosis-induced cell proliferation in vascular smooth muscle cells – Dimitra Aravani, Kirsty Foote, Nichola Figg, Alison Finigan, Anna Uryga, Murray Clarke, Martin Bennett. https://link.springer.com/article/10.1007/s10495-020-01622-4


Reviews


Emerging connectivity of programmed cell death pathways and its physiological implications – Sammy Bedoui, Marco J. Herold and Andreas Strasser. https://www.nature.com/articles/s41580-020-0270-8

Inflammasomes and Cell Death: Common Pathways in Microparticle Diseases – Maryam Rashidi, Ian P. Wicks, James E. Vince. https://www.cell.com/trends/molecular-medicine/fulltext/S1471-4914(20)30156-8

FLIP(L): the pseudo‐caspase – Peter Smyth, Tamas Sessler, Christopher J. Scott, Daniel B. Longley. https://febs.onlinelibrary.wiley.com/doi/full/10.1111/febs.15260

Emerging aspects in the regulation of ferroptosis – Helene Nehring, Svenja Meierjohann, Jose Pedro Friedmann Angeli. https://portlandpress.com/biochemsoctrans/article-abstract/doi/10.1042/BST20200523/226668/

Ferroptosis – Daolin Tang, Guido Kroemer. https://www.cell.com/current-biology/fulltext/S0960-9822(20)31438-X

Cardiolipin in Immune Signaling and Cell Death – Malvina Pizzuto, Pablo Pelegrin. https://www.cell.com/trends/cell-biology/fulltext/S0962-8924(20)30173-2

Cell Death in the Tumor Microenvironment: Implications for Cancer Immunotherapy – Varsha Gadiyar, Kevin C. Lahey, David Calianese, Connor Devoe, Dhriti Mehta, Kristy Bono, Samuel Desind, Viralkumar Davra and Raymond B. Birge. https://www.mdpi.com/2073-4409/9/10/2207

The role of death domain proteins in host response upon SARS-CoV-2 infection: modulation of programmed cell death and translational applications – Nikita V. Ivanisenko, Kamil Seyrek, Nikolay A. Kolchanov, Vladimir A. Ivanisenko and Inna N. Lavrik. https://www.nature.com/articles/s41420-020-00331-w

Interconnections among major forms of regulated cell death – Chaoyi Wu, Liting Zhou, Haibo Yuan, Shuyan Wu. https://link.springer.com/article/10.1007/s10495-020-01632-2


Comments


TRAIL and Cancer Immunotherapy: Take a Walk on the Short Side – Diego de Miguel and Julián Pardo. https://clincancerres.aacrjournals.org/content/26/21/5546

Caspase-8 protein cuts a brake on immune defences – Igor E. Brodsky. https://www.nature.com/articles/d41586-020-02994-y

PD-L1 controls cancer pyroptosis – María Teresa Blasco and Roger R. Gomis. https://www.nature.com/articles/s41556-020-00582-w

Immiscible immunity – Douglas R. Green. https://science-sciencemag-org.sire.ub.edu/content/370/6514/294.full

Apoptotic mitochondria prime anti-tumour immunity – Kate McArthur and Benjamin T. Kile. https://www.nature.com/articles/s41420-020-00335-6

MINORITY MOMP: A TOXIC, SLOW DEMISE – Yuan Xu, Deborah R. Surman,  and  R. Taylor Ripley. https://impactjournals.us9.list-manage.com/track/click?u=133779c099e52b6fa9d4dec2e&id=d5d624ce33&e=923b339f12

Letter to the editor: iron, apoptosis, and ferroptosis – Andrew J. Ghio. https://link.springer.com /article/10.1007/s10495-020-01628-y

A checkpoint for pyroptosis – Wei Wong. https://stke.sciencemag.org/content/13/655/eabf4018

The IAP Antagonist Debio 1143 Enhances Chemoradiotherapy in HNSCC. https://cancerdiscovery.aacrjournals.org/content/10/10/1437.1

Ferroptosis Is Inhibited in Lymph, Promoting Metastasis of Melanoma. https://cancerdiscovery.aacrjournals.org/content/10/11/1621.1

ApoList – September 2020


Bcl-2 family proteins


MCL-1 gains occur with high frequency in lung adenocarcinoma and can be targeted therapeuticallyEnkhtsetseg Munkhbaatar, Michelle Dietzen, Deepti Agrawal, Martina Anton, Moritz Jesinghaus, Melanie Boxberg, Nicole Pfarr, Pidassa Bidola, Sebastian Uhrig, Ulrike Höckendorf, Anna-Lena Meinhardt, Adam Wahida, Irina Heid, Rickmer Braren, Ritu Mishra, Arne Warth, Thomas Muley, Patrina S. P. Poh, Xin Wang, Stefan Fröhling, Katja Steiger, Julia Slotta-Huspenina, Martijn van Griensven, Franz Pfeiffer, Sebastian Lange, Roland Rad, Magda Spella, Georgios T. Stathopoulos, Jürgen Ruland, Florian Bassermann, Wilko Weichert, Andreas Strasser, Caterina Branca, Mathias Heikenwalder, Charles Swanton, Nicholas McGranahan and Philipp J. Jost. https://www.nature.com/articles/s41467-020-18372-1

The structural basis of Bcl-2 mediated cell death regulation in hydraSuresh Banjara, Jaison D Sa, Mark G. Hinds, Marc Kvansakul. https://portlandpress.com/biochemj/article/477/17/3287/226037

JNK1 and ERK1/2 modulate lymphocyte homeostasis via BIM and DRP1 upon AICD inductionLuca Simula, Mauro Corrado, Benedetta Accordi, Anthea Di Rita, Francesca Nazio, Ylenia Antonucci, Arianna Di Daniele, Federico Caicci, Ignazio Caruana, Maria Eugenia Soriano, Martina Pigazzi, Franco Locatelli, Francesco Cecconi and Silvia Campello. https://www.nature.com/articles/s41418-020-0540-1

Apoptotic stress induces Bax-dependent, caspase-independent redistribution of LINC complex nesprinsLiora Lindenboim, Dan Grozki, Ayelet R. Amsalem-Zafran, Aida Peña-Blanco, Gregg G. Gundersen, Christoph Borner, Didier Hodzic, Ana J. Garcia-Sáez, Howard J. Worman and Reuven Stein. https://www.nature.com/articles/s41420-020-00327-6

Modeling the function of BAX and BAK in early human brain development using iPSC-derived systemsPiyush Joshi, Caroline Bodnya, Megan L. Rasmussen, Alejandra I. Romero-Morales, Anna Bright and Vivian Gama. https://www.nature.com/articles/s41419-020-03002-x

BDA-366, a putative Bcl-2 BH4 domain antagonist, induces apoptosis independently of Bcl-2 in a variety of cancer cell modelsTamara Vervloessem, Binu K. Sasi, Elena Xerxa, Spyridoula Karamanou, Justin Kale, Rita M. La Rovere, Supriya Chakraborty, Flore Sneyers, Meike Vogler, Anastassios Economou, Luca Laurenti, David W. Andrews, Dimitar G. Efremov and Geert Bultynck. https://www.nature.com/articles/s41419-020-02944-6

CHIP ubiquitylates NOXA and induces its lysosomal degradation in response to DNA damageMarie-Christine Albert, Kerstin Brinkmann, Wojciech Pokrzywa, Saskia Diana Günther, Martin Krönke, Thorsten Hoppe and Hamid Kashkar. https://www.nature.com/articles/s41419-020-02923-x


Immunity / infection


Functional genomic landscape of cancer-intrinsic evasion of killing by T cellsKeith A. Lawson, Cristovão M. Sousa, Xiaoyu Zhang, Eiru Kim, Rummy Akthar, Joseph J. Caumanns, Yuxi Yao, Nicholas Mikolajewicz, Catherine Ross, Kevin R. Brown, Abdelrahman Abou Zid, Zi Peng Fan, Shirley Hui, Jordan A. Krall, Donald M. Simons, Chloe J. Slater, Victor De Jesus, Lujia Tang, Richa Singh, Joshua E. Goldford, Sarah Martin, Qian Huang, Elizabeth A. Francis, Andrea Habsid, Ryan Climie, David Tieu, Jiarun Wei, Ren Li, Amy Hin Yan Tong, Michael Aregger, Katherine S. Chan, Hong Han, Xiaowei Wang, Patricia Mero, John H. Brumell, Antonio Finelli, Laurie Ailles, Gary Bader, Gromoslaw A. Smolen, Gillian A. Kingsbury, Traver Hart, Charles Kung and Jason Moffat. https://www.nature.com/articles/s41586-020-2746-2

Structural insight into tanapoxvirus‐mediated inhibition of apoptosisChathura D. Suraweera, Mohd Ishtiaq Anasir, Srishti Chugh, Airah Javorsky, Rachael E. Impey, Mohammad Hasan Zadeh, Tatiana P. Soares da Costa, Mark G. Hinds, Marc Kvansakul. https://febs.onlinelibrary.wiley.com/doi/abs/10.1111/febs.15365

A unique bacterial tactic to circumvent the cell death crosstalk induced by blockade of caspase‐8Hiroshi Ashida, Chihiro Sasakawa, Toshihiko Suzuki. https://www.embopress.org/doi/full/10.15252/embj.2020104469


Death receptors / necroptosis


Modulating TRADD to restore cellular homeostasis and inhibit apoptosisDaichao Xu, Heng Zhao, Minzhi Jin, Hong Zhu, Bing Shan, Jiefei Geng, Slawomir A. Dziedzic, Palak Amin, Lauren Mifflin, Masanori Gomi Naito, Ayaz Najafov, Jing Xing, Lingjie Yan, Jianping Liu, Ying Qin, Xinqian Hu, Huibing Wang, Mengmeng Zhang, Vica Jean Manuel, Li Tan, Zhuohao He, Zhenyu J. Sun, Virginia M. Y. Lee, Gerhard Wagner and Junying Yuan. https://www.nature.com/articles/s41586-020-2757-z

Reduction in MLKL-mediated endosomal trafficking enhances the TRAIL-DR4/5 signal to increase cancer cell deathSe-Yeon Park, Han-Hee Park, Sang-Yeong Park, Sun Mi Hong, Seongmin Yoon, Michael J. Morgan and You-Sun Kim. https://www.nature.com/articles/s41419-020-02941-9


Caspases and IAPs


The apoptosome molecular timer synergises with XIAP to suppress apoptosis execution and contributes to prognosticating survival in colorectal cancerGavin Fullstone, Tabea L. Bauer, Cristiano Guttà, Manuela Salvucci, Jochen H. M. Prehn and Markus Rehm. https://www.nature.com/articles/s41418-020-0545-9

Targeting triple-negative breast cancers with the Smac-mimetic birinapantNajoua Lalaoui, Delphine Merino, Goknur Giner, François Vaillant, Diep Chau, Lin Liu, Tobias Kratina, Bhupinder Pal, James R. Whittle, Nima Etemadi, Jean Berthelet, Julius Gräsel, Cathrine Hall, Matthew E. Ritchie, Matthias Ernst, Gordon K. Smyth, David L. Vaux, Jane E. Visvader, Geoffrey J. Lindeman and John Silke. https://www.nature.com/articles/s41418-020-0541-0

CASP9 (caspase 9) is essential for autophagosome maturation through regulation of mitochondrial homeostasisHyun-Kyu An, Kyung Min Chung, Hyunhee Park, Jihyun Hong, Ji-Eun Gim, Hyosun Choi, Ye Won Lee, Jieun Choi, Ji Young Mun and Seong-Woon Yu. https://www.tandfonline.com/doi/abs/10.1080/15548627.2019.1695398


Pyroptosis


Succination inactivates gasdermin D and blocks pyroptosisFiachra Humphries, Liraz Shmuel-Galia, Natalia Ketelut-Carneiro, Sheng Li, Bingwei Wang, Venkatesh V. Nemmara, Ruth Wilson, Zhaozhao Jiang, Farnaz Khalighinejad, Khaja Muneeruddin, Scott A. Shaffer, Ranjan Dutta, Carolina Ionete, Scott Pesiridis, Shuo Yang, Paul R. Thompson, Katherine A. Fitzgerald. https://science.sciencemag.org/content/369/6511/1633

Caspase-8 mediates inflammation and disease in rodent malariaLarissa M. N. Pereira, Patrícia A. Assis, Natalia M. de Araújo, Danielle F. Durso, Caroline Junqueira, Marco Antônio Ataíde, Dhelio B. Pereira, Egil Lien, Katherine A. Fitzgerald, Dario S. Zamboni, Douglas T. Golenbock and Ricardo T. Gazzinelli. https://www.nature.com/articles/s41467-020-18295-x

Indirect regulation of HMGB1 release by gasdermin DAllen Volchuk, Anna Ye, Leon Chi, Benjamin E. Steinberg and Neil M. Goldenberg. https://www.nature.com/articles/s41467-020-18443-3


Ferroptosis


Plasticity of ether lipids promotes ferroptosis susceptibility and evasionYilong Zou, Whitney S. Henry, Emily L. Ricq, Emily T. Graham, Vaishnavi V. Phadnis, Pema Maretich, Sateja Paradkar, Natalie Boehnke, Amy A. Deik, Ferenc Reinhardt, John K. Eaton, Bryan Ferguson, Wenyu Wang, Joshua Fairman, Heather R. Keys, Vlado Dančík, Clary B. Clish, Paul A. Clemons, Paula T. Hammond, Laurie A. Boyer, Robert A. Weinberg and Stuart L. Schreiber. https://www.nature.com/articles/s41586-020-2732-8

Alpha synuclein aggregation drives ferroptosis: an interplay of iron, calcium and lipid peroxidationPlamena R. Angelova, Minee L. Choi, Alexey V. Berezhnov, Mathew H. Horrocks, Craig D. Hughes, Suman De, Margarida Rodrigues, Ratsuda Yapom, Daniel Little, Karamjit S. Dolt, Tilo Kunath, Michael J. Devine, Paul Gissen, Mikhail S. Shchepinov, Sergiy Sylantyev, Evgeny V. Pavlov, David Klenerman, Andrey Y. Abramov and Sonia Gandhi. https://www.nature.com/articles/s41418-020-0542-z


Miscellanous


Diversifying the platinum-based chemotherapy toolkit for immunogenic cancer cell deathAbhishek D. Garg and Patrizia Agostinis. https://impactjournals.us9.list-manage.com/track/click?u=133779c099e52b6fa9d4dec2e&id=1561a2e654&e=923b339f12

The antitumour drug ABTL0812 impairs neuroblastoma growth through endoplasmic reticulum stress-mediated autophagy and apoptosisLaia París-Coderch, Aroa Soriano, Carlos Jiménez, Tatiana Erazo, Pau Muñoz-Guardiola, Marc Masanas, Roberta Antonelli, Ariadna Boloix, José Alfón, Héctor Pérez-Montoyo, Marc Yeste-Velasco, Carles Domènech, Josep Roma, Josep Sánchez de Toledo, Lucas Moreno, José M. Lizcano, Soledad Gallego and Miguel F. Segura. https://www.nature.com/articles/s41419-020-02986-w


Reviews / comments


Together we stand, apart we fall: how cell-to-cell contact/interplay provides resistance to ferroptosisMilica Vucetic, Boutaina Daher, Shamir Cassim, Willian Meira and Jacques Pouyssegur. https://www.nature.com/articles/s41419-020-02994-w

The BCL-2 family sagaAna J. García-Sáez. https://www.nature.com/articles/s41580-020-0276-2

Preventing pores and inflammationRobert J. Pickering, Clare E. Bryant. https://science.sciencemag.org/content/369/6511/1564

ApoList – August 2020


Bcl-2 family proteins


Venetoclax causes metabolic reprogramming independent of BCL-2 inhibition – Alba Roca-Portoles, Giovanny Rodriguez-Blanco, David Sumpton, Catherine Cloix, Margaret Mullin, Gillian M. Mackay, Katelyn O’Neill, Leandro Lemgruber, Xu Luo and Stephen W. G. Tait. https://www.nature.com/articles/s41419-020-02867-2

Sequential combinations of chemotherapeutic agents with BH3 mimetics to treat rhabdomyosarcoma and avoid resistanceClara Alcon, Albert Manzano-Muñoz, Estela Prada, Jaume Mora, Aroa Soriano, Gabriela Guillén, Soledad Gallego, Josep Roma, Josep Samitier, Alberto Villanueva and Joan Montero. https://www.nature.com/articles/s41419-020-02887-y

Dual Targeting of CDK4/6 and BCL2 Pathways Augments Tumor Response in Estrogen Receptor–Positive Breast Cancer – James R. Whittle, François Vaillant, Elliot Surgenor, Antonia N. Policheni, Göknur Giner, Bianca D. Capaldo, Huei-Rong Chen, He K. Liu, Johanna F. Dekkers, Norman Sachs, Hans Clevers, Andrew Fellowes, Thomas Green, Huiling Xu, Stephen B. Fox, Marco J. Herold, Gordon K. Smyth, Daniel H.D. Gray, Jane E. Visvader and Geoffrey J. Lindeman. https://clincancerres.aacrjournals.org/content/26/15/4120

Integrated analysis of patient samples identifies biomarkers for venetoclax efficacy and combination strategies in acute myeloid leukemia – Haijiao Zhang, Yusuke Nakauchi, Thomas Köhnke, Melissa Stafford, Daniel Bottomly, Rozario Thomas, Beth Wilmot, Shannon K. McWeeney, Ravindra Majeti and Jeffrey W. Tyner. https://www.nature.com/articles/s43018-020-0103-x

ATG16L1 autophagy pathway regulates BAX protein levels and programmed cell death – Fenfen Chen, Dulguun Amgalan, Richard N. Kitsis, Jeffrey E. Pessin and Daorong Feng. http://www.jbc.org/content/early/2020/08/26/jbc.RA120.013999.abstract

The BCL-2 selective inhibitor ABT-199 sensitizes soft tissue sarcomas to proteasome inhibition by a concerted mechanism requiring BAX and NOXA – Alina Muenchow, Sandra Weller, Clemens Hinterleitner, Elke Malenke, Stefanie Bugl, Stefan Wirths, Martin R. Müller, Klaus Schulze-Osthoff, Walter E. Aulitzky, Hans-Georg Kopp and Frank Essmann. https://www.nature.com/articles/s41419-020-02910-2


Death receptors


A TRAIL-TL1A Paracrine Network Involving Adipocytes, Macrophages and lymphocytes Induces Adipose Tissue Dysfunction Downstream of E2F1 in Human Obesity – Nitzan Maixner, Tal Pecht, Yulia Haim, Vered Chalifa-Caspi, Nir Goldstein, Tania Tarnovscki, Idit F. Liberty, Boris Kirshtein, Rachel Golan, Omer Berner, Alon Monsonego, Nava Bashan, Matthias Blüher, Assaf Rudich. https://diabetes.diabetesjournals.org/content/early/2020/07/30/db19-1231.long

The SCFSkp2 ubiquitin ligase complex modulates TRAIL-R2-induced apoptosis by regulating FLIP(L) – Jamie Z. Roberts, Caitriona Holohan, Tamas Sessler, Jennifer Fox, Nyree Crawford, Joel S. Riley, Hajrah Khawaja, Joanna Majkut, Emma Evergren, Luke M. Humphreys, Jennifer Ferris, Catherine Higgins, Margarita Espona-Fiedler, Paul Moynagh, Simon S. McDade and Daniel B. Longley. https://www.nature.com/articles/s41418-020-0539-7

Tristetraprolin Posttranscriptionally Downregulates TRAIL Death Receptors – Won Hyeok Lee, Myung Woul Han, Song Hee Kim, Daseul Seong, Jae Hee An, Hyo Won Chang, Sang Yoon Kim, Seong Who Kim and Jong Cheol Lee. https://www.mdpi.com/2073-4409/9/8/1851

NORE1A directs apoptotic switch of TNF signaling through reciprocal modulation of ITCH-mediated destruction of TNFRI and BAX – Kyung-Phil Ko, Seong-In Jeong, Ji-Sun Lim, Kyung-Woo Lee, Min-Goo Lee and Sung-Gil Chi. https://www.nature.com/articles/s41388-020-01392-y

ALG2 Influences T cell apoptosis by regulating FASLG intracellular transportation – Wangsheng Ji; Yang Xin; Lianfei Zhang; Xinqi Liu. https://portlandpress.com/biochemj/article-abstract/477/16/3105/226005


Caspases and IAPs


14‐3‐3 protein binding blocks the dimerization interface of caspase‐2 – Dana Kalabova, Frantisek Filandr, Miroslava Alblova, Olivia Petrvalska, Matej Horvath, Petr Man, Tomas Obsil, Veronika Obsilova. https://febs.onlinelibrary.wiley.com/doi/abs/10.1111/febs.15215

BIRC2 Expression Impairs Anti-Cancer Immunity and Immunotherapy Efficacy [c-IAP1] – Debangshu Samanta, Tina Yi-Ting Huang, Rima Shah, Yongkang Yang, Fan Pan, Gregg L. Semenza. https://www.cell.com/cell-reports/fulltext/S2211-1247(20)31058-5


Necroptosis


Identification of MYC as an antinecroptotic protein that stifles RIPK1–RIPK3 complex formation – Daehyeon Seong, Manhyung Jeong, Jinho Seo, Ji-Yoon Lee, Chi Hyun Hwang, Ho-Chul Shin, Jeong Yoon Shin, Young Woo Nam, Jeong Yeon Jo, Haeseung Lee, Hye-Jung Kim, Hwa-Ryeon Kim, Ji Hoon Oh, Sang-Jun Ha, Seung Jun Kim, Jae-Seok Roe, Wankyu Kim, June-Won Cheong, Kwang-Hee Bae, Sang Chul Lee, Andrew Oberst, Peter Vandenabeele, Dong Hoon Shin, Eun-Woo Lee, and Jaewhan Song. https://www.pnas.org/content/117/33/19982.abstract?etoc

Catalytically inactive RIP1 and RIP3 deficiency protect against acute ischemic stroke by inhibiting necroptosis and neuroinflammation – Yue Zhang, Ming Li, Xiaoming Li, Haiwei Zhang, Lingxia Wang, Xiaoxia Wu, Haibing Zhang and Yan Luo. https://www.nature.com/articles/s41419-020-02770-w

Autocrine IL6-Mediated Activation of the STAT3–DNMT Axis Silences the TNFα–RIP1 Necroptosis Pathway to Sustain Survival and Accumulation of Myeloid-Derived Suppressor Cells – Alyssa D. Smith, Chunwan Lu, Daniela Payne, Amy V. Paschall, John D. Klement, Priscilla S. Redd, Mohammed L. Ibrahim, Dafeng Yang, Qimei Han, Zhuoqi Liu, Huidong Shi, Thomas J. Hartney, Asha Nayak-Kapoor and Kebin Liu. https://cancerres.aacrjournals.org/content/80/15/3145

Human cytomegalovirus protein pUL36: A dual cell death pathway inhibitor – Alice Fletcher-Etherington, Luis Nobre, Katie Nightingale, Robin Antrobus, Jenna Nichols, Andrew J. Davison, Richard J. Stanton, and Michael P. Weekes. https://www.pnas.org/content/117/31/18771.abstract?etoc

Necroptosis-based CRISPR knockout screen reveals Neuropilin-1 as a critical host factor for early stages of murine cytomegalovirus infection – Rebecca K. Lane, Hongyan Guo, Amanda D. Fisher, Jonathan Diep, Zhao Lai, Yidong Chen, Jason W. Upton, Jan Carette, Edward S. Mocarski, and William J. Kaiser. https://www.pnas.org/content/117/33/20109.abstract?etoc

Influenza-Induced Oxidative Stress Sensitizes Lung Cells to Bacterial-Toxin-Mediated Necroptosis – Norberto Gonzalez-Juarbe, Ashleigh N. Riegler, Alexander S. Jureka, Ryan P. Gilley, Jeffrey D. Brand, John E. Trombley, Ninecia R. Scott, Maryann P. Platt, Peter H. Dube, Chad M. Petit, Kevin S. Harrod, Carlos J. Orihuela. https://www.cell.com/cell-reports/fulltext/S2211-1247(20)31047-0

In vitro analysis reveals necroptotic signaling does not provoke DNA damage or HPRT mutations – Mark A. Miles and Christine J. Hawkins. https://www.nature.com/articles/s41419-020-02879-y


Ferroptosis


Ferroptosis occurs through an osmotic mechanism and propagates independently of cell rupture – Michelle Riegman, Liran Sagie, Chen Galed, Tom Levin, Noah Steinberg, Scott J. Dixon, Ulrich Wiesner, Michelle S. Bradbury, Philipp Niethammer, Assaf Zaritsky and Michael Overholtzer. https://www.nature.com/articles/s41556-020-0565-1?sf237346546=1

Lymph protects metastasizing melanoma cells from ferroptosis – Jessalyn M. Ubellacker, Alpaslan Tasdogan, Vijayashree Ramesh, Bo Shen, Evann C. Mitchell, Misty S. Martin-Sandoval, Zhimin Gu, Michael L. McCormick, Alison B. Durham, Douglas R. Spitz, Zhiyu Zhao, Thomas P. Mathews and Sean J. Morrison. https://www.nature.com/articles/s41586-020-2623-z

Dietary Lipids Induce Ferroptosis in Caenorhabditis elegans and Human Cancer Cells – Marcos A. Perez, Leslie Magtanong, Scott J. Dixon, Jennifer L. Watts. https://www.cell.com/developmental-cell/fulltext/S1534-5807(20)30498-6


Pyroptosis/mixed pathways


Impaired NLRP3 inflammasome activation/pyroptosis leads to robust inflammatory cell death via caspase-8/RIPK3 during coronavirus infection – Min Zheng, Evan Peter Williams, R. K. Subbarao Malireddi, Rajendra Karki, Balaji Banoth, Amanda Burton, Richard Webby, Rudragouda Channappanavar, Colleen Beth Jonsson and Thirumala-Devi Kanneganti. http://www.jbc.org/content/early/2020/08/06/jbc.RA120.015036.abstract

RIPK3 collaborates with GSDMD to drive tissue injury in lethal polymicrobial sepsis – Hui Chen, Yinshuang Li, Jianfeng Wu, Guoping Li, Xuan Tao, Kunmei Lai, Ying Yuan, Xiaohong Zhang, Zhenhuan Zou and Yanfang Xu. https://www.nature.com/articles/s41418-020-0524-1


Miscellanous


A fluorogenic cyclic peptide for imaging and quantification of drug-induced apoptosis – Nicole D. Barth, Ramon Subiros-Funosas, Lorena Mendive-Tapia, Rodger Duffin, Mario A. Shields, Jennifer A. Cartwright, Sónia Troeira Henriques, Jesus Sot, Felix M. Goñi, Rodolfo Lavilla, John A. Marwick, Sonja Vermeren, Adriano G. Rossi, Mikala Egeblad, Ian Dransfield and Marc Vendrell. https://www.nature.com/articles/s41467-020-17772-7

A splicing isoform of GPR56 mediates microglial synaptic refinement via phosphatidylserine binding – Tao Li, Brian Chiou, Casey K Gilman, Rong Luo, Tatsuhiro Koshi, Diankun Yu, Hayeon C Oak, Stefanie Giera, Erin Johnson‐Venkatesh, Allie K Muthukumar, Beth Stevens, Hisashi Umemori, Xianhua Piao. https://www.embopress.org/doi/abs/10.15252/embj.2019104136

Local externalization of phosphatidylserine mediates developmental synaptic pruning by microglia – Nicole Scott‐Hewitt, Fabio Perrucci, Raffaella Morini, Marco Erreni, Matthew Mahoney, Agata Witkowska, Alanna Carey, Elisa Faggiani, Lisa Theresia Schuetz, Sydney Mason, Matteo Tamborini, Matteo Bizzotto, Lorena Passoni, Fabia Filipello, Reinhard Jahn, Beth Stevens, Michela Matteoli. https://www.embopress.org/doi/full/10.15252/embj.2020105380

Dead cells release a ‘necrosignal’ that activates antibiotic survival pathways in bacterial swarms – Souvik Bhattacharyya, David M. Walker and Rasika M. Harshey. https://www.nature.com/articles/s41467-020-17709-0

Phosphorylation of cyclophilin D at serine 191 regulates mitochondrial permeability transition pore opening and cell death after ischemia-reperfusion – Stephen Hurst, Fabrice Gonnot, Maya Dia, Claire Crola Da Silva, Ludovic Gomez and Shey-Shing Sheu. https://www.nature.com/articles/s41419-020-02864-5


Reviews


Ferroptosis: Machinery and Regulation – Xin Chen, Jingbo Li, Rui Kang, Daniel J. Klionsky and Daolin Tang. https://www.tandfonline.com/doi/abs/10.1080/15548627.2020.1810918

Ubiquitination and deubiquitination of MCL1 in cancer: deciphering chemoresistance mechanisms and providing potential therapeutic options – Xiaowei Wu, Qingyu Luo and Zhihua Liu. https://www.nature.com/articles/s41419-020-02760-y

Autophagy as a modulator of cell death machinery – Masayuki Noguchi, Noriyuki Hirata, Tsutomu Tanaka, Futoshi Suizu, Hiroshi Nakajima and John A. Chiorini. https://www.nature.com/articles/s41419-020-2724-5


Comments / other


Igniting the spread of ferroptotic cell death – Andrew J. Davidson and Will Wood. https://www.nature.com/articles/s41556-020-0570-4

Please eat (only part) of me: synaptic phosphatidylserine cues microglia to feast : Two new studies identify how a common apoptotic cell flag is used to sculpt neural circuits – Graham Peet, F Chris Bennett, Mariko L Bennett. https://www.embopress.org/doi/abs/10.15252/embj.2020105924

In memoriam: Dr. Beth Levine (1960–2020)Jennifer Martinez. https://www.nature.com/articles/s41418-020-0595-z

On Sten Orrenius (1937–2020) – Boris Zhivotovsky and Pierluigi Nicotera. https://www.nature.com/articles/s41418-020-0594-0

Beth Levine (1960–2020) – Ramnik J. Xavier, Herbert W. Virgin. https://www.cell.com/molecular-cell/fulltext/S1097-2765(20)30514-1

Beth Levine 1960–2020 – Anna Katharina Simon and Noboru Mizushima. https://www.nature.com/articles/s41556-020-0555-3

Remembering Beth Levine – the autophagy pioneer and woman extraordinaire – Salwa Sebti, Congcong He, Sophie Pattingre, Alicia Meléndez, Ana Maria Cuervo, J. Marie Hardwick, Diane E. Griffin. https://febs.onlinelibrary.wiley.com/doi/full/10.1111/febs.15502

ApoList – July 2020


Bcl-2 family proteins


Homogeneous Oligomers of Pro-apoptotic BAX Reveal Structural Determinants of Mitochondrial Membrane Permeabilization – Zachary J. Hauseman, Edward P. Harvey, Catherine E. Newman, Thomas E. Wales, Joel C. Bucci, Julian Mintseris, Devin K. Schweppe, Liron David, Lixin Fan, Daniel T. Cohen, Henry D. Herce, Rida Mourtada, Yael Ben-Nun, Noah B. Bloch, Scott B. Hansen, Hao Wu, Steven P. Gygi, John R. Engen, Loren D. Walensky. https://www.cell.com/molecular-cell/fulltext/S1097-2765(20)30349-X

Changes in Bcl-2 members in response to ibrutinib or venetoclax uncover functional hierarchy in determining resistance to venetoclax in CLL – Haselager MV, Kielbassa K, Ter Burg J, Bax DJC, Fernandes SM, Borst J, Tam C, Forconi F, Chiodin G, Brown JR, Dubois J, Kater AP, Eldering E. https://doi.org/10.1182/blood.2019004326

Caspase-1 cleaves Bid to release mitochondrial SMAC and drive secondary necrosis in the absence of GSDMD – Rosalie Heilig, Marisa Dilucca, Dave Boucher, Kaiwen W Chen, Dora Hancz, Benjamin Demarco, Kateryna Shkarina and Petr Broz. https://www.life-science-alliance.org/content/3/6/e202000735.abstract

5-Azacitidine Induces NOXA to Prime AML Cells for Venetoclax-Mediated Apoptosis – Sha Jin, Dan Cojocari, Julie J. Purkal, Relja Popovic, Nari N. Talaty, Yu Xiao, Larry R. Solomon, Erwin R. Boghaert, Joel D. Leverson and Darren C. Phillips. https://clincancerres.aacrjournals.org/content/26/13/3371

Spermine synthase and MYC cooperate to maintain colorectal cancer cell survival by repressing Bim expression – Yubin Guo, Qing Ye, Pan Deng, Yanan Cao, Daheng He, Zhaohe Zhou, Chi Wang, Yekaterina Y. Zaytseva, Charles E. Schwartz, Eun Y. Lee, B. Mark Evers, Andrew J. Morris, Side Liu and Qing-Bai She. https://www.nature.com/articles/s41467-020-17067-x

Characterization of an alternative BAK-binding site for BH3 peptides – Kaiqin Ye, Wei X. Meng, Hongbin Sun, Bo Wu, Meng Chen, Yuan-Ping Pang, Jia Gao, Hongzhi Wang, Junfeng Wang, Scott H. Kaufmann and Haiming Dai. https://www.nature.com/articles/s41467-020-17074-y

The chaperone Hsp70 is a BH3 receptor activated by the pro-apoptotic Bim to stabilize anti-apoptotic clients – Zongwei Guo, Ting Song, Ziqian Wang, Donghai Lin, Keke Cao, Peng Liu, Yingang Feng, Xiaodong Zhang, Peiran Wang and Zhichao Zhang. http://www.jbc.org/content/early/2020/07/10/jbc.RA120.013364.abstract

MARCH5 requires MTCH2 to coordinate proteasomal turnover of the MCL1:NOXA complex – Tirta Mario Djajawi, Lei Liu, Jia-nan Gong, Allan Shuai Huang, Ming-jie Luo, Zhen Xu, Toru Okamoto, Melissa J. Call, David C. S. Huang and Mark F. van Delft. https://www.nature.com/articles/s41418-020-0517-0


Death receptors


Engineering bacterial outer membrane vesicles as transdermal nanoplatforms for photo-TRAIL-programmed therapy against melanoma – Li-Hua Peng , Mao-Ze Wang, Yang Chu, Lei Zhang, Jie Niu, Hai-Tao Shao, Tie-Jun Yuan, Zhi-Hong Jiang, Jian-Qing Gao, Xing-Hai Ning. https://advances.sciencemag.org/content/6/27/eaba2735

Convergence of pathway analysis and pattern recognition predicts sensitization to latest generation TRAIL therapeutics by IAP antagonism – Vesna Vetma, Cristiano Guttà, Nathalie Peters, Christian Praetorius, Meike Hutt, Oliver Seifert, Friedegund Meier, Roland Kontermann, Dagmar Kulms and Markus Rehm. https://www.nature.com/articles/s41418-020-0512-5

The pseudo-caspase FLIP(L) regulates cell fate following p53 activation – Andrea Lees, Alexander J. McIntyre, Nyree T. Crawford, Fiammetta Falcone, Christopher McCann, Caitriona Holohan, Gerard P. Quinn, Jamie Z. Roberts, Tamas Sessler, Peter F. Gallagher, Gemma M. A. Gregg, Katherine McAllister, Kirsty M. McLaughlin, Wendy L. Allen, Laurence J. Egan, Aideen E. Ryan, Melissa J. Labonte-Wilson, Philip D. Dunne, Mark Wappett, Vicky M. Coyle, Patrick G. Johnston, Emma M. Kerr, Daniel B. Longley, and Simon S. McDade. https://www.pnas.org/content/117/30/17808.abstract?etoc


Necroptosis


Loss of RIPK3 does not impact MYC-driven lymphomagenesis or chemotherapeutic drug-induced killing of malignant lymphoma cells – Rachel Thijssen, Silvia Alvarez-Diaz, Clea Grace, Ming-yuan Gao, David H. Segal, Zhen Xu, Andreas Strasser and David C. S. Huang. https://www.nature.com/articles/s41418-020-0576-2


Pyroptosis


An Apoptotic Caspase Network Safeguards Cell Death Induction in Pyroptotic MacrophagesNathalia Moraes de Vasconcelos, Nina Van Opdenbosch, Hanne Van Gorp, Rosa Martín-Pérez, Annalisa Zecchin, Peter Vandenabeele, Mohamed Lamkanfi. https://www.cell.com/cell-reports/fulltext/S2211-1247(20)30940-2

Caspase-1 Engages Full-Length Gasdermin D through Two Distinct Interfaces That Mediate Caspase Recruitment and Substrate Cleavage – Zhonghua Liu, Chuanping Wang, Jie Yang, Yinghua Chen, Bowen Zhou, Derek W. Abbott, Tsan Sam Xiao. https://www.cell.com/immunity/fulltext/S1074-7613(20)30237-5

Neutrophil Caspase-11 Is Essential to Defend against a Cytosol-Invasive Bacterium – Stephen B. Kovacs, Changhoon Oh, Vivien I. Maltez, Benjamin D. McGlaughon, Ambika Verma, Edward A. Miao, Youssef Aachoui. https://www.cell.com/cell-reports/fulltext/S2211-1247(20)30948-7


Ferroptosis and miscellaneous necrosis


Smac mimetics can provoke lytic cell death that is neither apoptotic nor necroptotic – Mark A. Miles, Sarah Caruso, Amy A. Baxter, Ivan K. H. Poon, Christine J. Hawkins. https://link.springer.com/article/10.1007/s10495-020-01610-8

Changes in ferrous iron and glutathione promote ferroptosis and frailty in aging Caenorhabditis elegans – Nicole L Jenkins, Simon A James, Agus Salim, Fransisca Sumardy, Terence P Speed, Marcus Conrad, Des R Richardson, Ashley I Bush , Gawain McColl. https://elifesciences.org/articles/56580

Hexokinase 2 displacement from mitochondria‐associated membranes prompts  Ca2+‐dependent death of cancer cellsFrancesco Ciscato, Riccardo Filadi, Ionica Masgras, Marco Pizzi, Oriano Marin, Nunzio Damiano, Paola  Pizzo, Alessandro Gori, Federica Frezzato, Federica Chiara, Livio Trentin, Paolo Bernardi, Andrea  Rasola. https://www.embopress.org/doi/full/10.15252/embr.201949117


Miscellanous


Kinetic Heterogeneity of Cancer Cell Fractional Killing – Zintis Inde, Giovanni C. Forcina, Kyle Denton, Scott J. Dixon. https://www.cell.com/cell-reports/fulltext/S2211-1247(20)30826-3

Flow cytometric detection of hyper-polarized mitochondria in regulated and accidental cell death processes – G. Warnes. https://link.springer.com/article/10.1007/s10495-020-01613-5


Reviews


Double agents of cell death: novel emerging functions of apoptotic regulators – Heather M. Lamb. https://febs.onlinelibrary.wiley.com/doi/full/10.1111/febs.15308

Rational design of genetically encoded reporter genes for optical imaging of apoptosis – Zhijing Xu, Yingzhuang Song, Fu Wang. https://link.springer.com/article/10.1007/s10495-020-01621-5

The mitochondrial permeability transition pore: Is it formed by the ATP synthase, adenine nucleotide translocators or both? – Christopher P. Baines, Manuel Gutiérrez-Aguilar. https://www.sciencedirect.com/science/article/abs/pii/S0005272820300992


Comments


Snapshot of a Deadly Embrace: The Caspase-1-GSDMD Interface – Lieselotte Vande Walle, Mohamed Lamkanfi. https://www.cell.com/immunity/fulltext/S1074-7613(20)30274-0

Memoriam – Beth Levine in memoriam. https://www.tandfonline.com/doi/full/10.1080/15548627.2020.1787721

ApoList – June 2020


Bcl-2 family – biology


Endolysosomal Targeting of Mitochondria Is Integral to BAX-Mediated Mitochondrial Permeabilization during Apoptosis SignalingTim Sen Wang, Isabelle Coppens, Anna Saorin, Nathan Ryan Brady, Anne Hamacher-Brady. https://www.cell.com/developmental-cell/fulltext/S1534-5807(20)30403-2

MARCH5 mediates NOXA-dependent MCL1 degradation driven by kinase inhibitors and integrated stress response activationSeiji Arai, Andreas Varkaris, Mannan Nouri, Sen Chen, Lisha Xie, Steven P Balk. https://elifesciences.org/articles/54954

BIF-1 inhibits both mitochondrial and glycolytic ATP production: its downregulation promotes melanoma growthŽiva Frangež, Yuniel Fernández-Marrero, Darko Stojkov, S. Morteza Seyed Jafari, Robert E. Hunger, Valentin Djonov, Carsten Riether and Hans-Uwe Simon. https://www.nature.com/articles/s41388-020-1339-8

Pro-death signaling of cytoprotective heat shock factor 1: upregulation of NOXA leading to apoptosis in heat-sensitive cellsPatryk Janus, Agnieszka Toma-Jonik, Natalia Vydra, Katarzyna Mrowiec, Joanna Korfanty, Marek Chadalski, Piotr Widłak, Karolina Dudek, Anna Paszek, Marek Rusin, Joanna Polańska and Wiesława Widłak. https://www.nature.com/articles/s41418-020-0501-8

Glucocorticoids can induce BIM to trigger apoptosis in the absence of BAX and BAK1Li Dong and David L. Vaux. https://www.nature.com/articles/s41419-020-2599-5

The pro-survival Bcl-2 family member A1 delays spontaneous and FAS ligand-induced apoptosis of activated neutrophilsRobyn L. Schenk, Lahiru Gangoda, Kate E. Lawlor, Lorraine A. O’Reilly, Andreas Strasser and Marco J. Herold. https://www.nature.com/articles/s41419-020-2676-9

Defective nucleotide-dependent assembly and membrane fusion in Mfn2 CMT2A variants improved by BaxNyssa B Samanas, Emily A Engelhart and Suzanne Hoppins. https://www.life-science-alliance.org/content/3/5/e201900527.abstract


BH3 proteins and cancer


Failed Apoptosis Enhances Melanoma Cancer Cell AggressivenessKevin Berthenet, Camila Castillo Ferrer, Deborah Fanfone, Nikolay Popgeorgiev, David Neves, Philippe Bertolino, Benjamin Gibert, Hector Hernandez-Vargas, Gabriel Ichim. https://www.cell.com/cell-reports/fulltext/S2211-1247(20)30711-7

High-throughput dynamic BH3 profiling may quickly and accurately predict effective therapies in solid tumorsPatrick D. Bhola , Eman Ahmed, Jennifer L. Guerriero, Ewa Sicinska, Emily Su, Elizaveta Lavrova, Jing Ni, Otari Chipashvili, Timothy Hagan, Marissa S. Pioso, Kelley McQueeney, Kimmie Ng, Andrew J. Aguirre, James M. Cleary, David Cocozziello, Alaba Sotayo, Jeremy Ryan, Jean J. Zhao, Anthony Letai. https://stke.sciencemag.org/content/13/636/eaay1451

MCL1 inhibitors S63845/MIK665 plus Navitoclax synergistically kill difficult-to-treat melanoma cellsNabanita Mukherjee, Jenette Skees, Kaleb J. Todd, Drake A. West, Karoline A. Lambert, William A. Robinson, Carol M. Amato, Kasey L. Couts, Robert Van Gulick, Morgan MacBeth, Kelsey Nassar, Aik-Choon Tan, Zili Zhai, Mayumi Fujita, Stacey M. Bagby, Chiara R. Dart, James R. Lambert, David A. Norris and Yiqun G. Shellman. https://www.nature.com/articles/s41419-020-2646-2

BIK drives an aggressive breast cancer phenotype through sublethal apoptosis and predicts poor prognosis of ER-positive breast cancerVrajesh Pandya, John Maringa Githaka, Namrata Patel, Richard Veldhoen, Judith Hugh, Sambasivarao Damaraju, Todd McMullen, John Mackey and Ing Swie Goping. https://www.nature.com/articles/s41419-020-2654-2

Deep profiling of apoptotic pathways with mass cytometry identifies a synergistic drug combination for killing myeloma cellsCharis E. Teh, Jia-Nan Gong, David Segal, Tania Tan, Cassandra J. Vandenberg et al. https://www.nature.com/articles/s41418-020-0498-z


DISC


Caspase-8-Dependent Inflammatory Responses Are Controlled by Its Adaptor, FADD, and NecroptosisBart Tummers, Luigi Mari, Clifford S. Guy, Bradlee L. Heckmann, Diego A. Rodriguez, Sebastian Rühl, Julien Moretti, Jeremy Chase Crawford, Patrick Fitzgerald, Thirumala-Devi Kanneganti, Laura J. Janke, Stephane Pelletier, J. Magarian Blander, Douglas R. Green. https://www.cell.com/immunity/fulltext/S1074-7613(20)30168-0

FADD and Caspase-8 Regulate Gut Homeostasis and Inflammation by Controlling MLKL- and GSDMD-Mediated Death of Intestinal Epithelial CellsRobin Schwarzer, Huipeng Jiao, Laurens Wachsmuth, Achim Tresch, Manolis Pasparakis. https://www.cell.com/immunity/fulltext/S1074-7613(20)30160-6

Dissecting DISC regulation via pharmacological targeting of caspase-8/c-FLIPL heterodimerLaura K. Hillert, Nikita V. Ivanisenko, Denise Busse, Johannes Espe, Corinna König, Sergey E. Peltek, Nikolai A. Kolchanov, Vladimir A. Ivanisenko and Inna N. Lavrik. https://www.nature.com/articles/s41418-020-0489-0

Cytomegalovirus inhibition of extrinsic apoptosis determines fitness and resistance to cytotoxic CD8 T cellsM. Zeeshan Chaudhry, Rosaely Casalegno-Garduno, Katarzyna M. Sitnik, Bahram Kasmapour, Ann-Kathrin Pulm, Ilija Brizic, Britta Eiz-Vesper, Andreas Moosmann, Stipan Jonjic, Edward S. Mocarski, and Luka Cicin-Sain. https://www.pnas.org/content/117/23/12961.abstract?etoc


Caspases and IAPs


Noncanonical inhibition of caspase-3 by a nuclear microRNA confers endothelial protection by autophagy in atherosclerosisDonato Santovito , Virginia Egea, Kiril Bidzhekov, Lucia Natarelli, André Mourão, Xavier Blanchet, Kanin Wichapong, Maria Aslani, Coy Brunßen, Michael Horckmans, Michael Hristov, Arie Geerlof, Esther Lutgens, Mat J.A.P. Daemen, Tilman Hackeng, Christian Ries, Triantafyllos Chavakis, Henning Morawietz, Ronald Naumann, Philipp von Hundelshausen, Sabine Steffens, Johan Duchêne, Remco T.A. Megens, Michael Sattler, Christian Weber. https://stm.sciencemag.org/content/12/546/eaaz2294

The Lumiptosome, an engineered luminescent form of the apoptosome can report cell death by using the same Apaf-1 dependent pathwayElaheh Sadat Hosseini, Maryam Nikkhah, Amir Ali Hamidieh, Howard O. Fearnhead, Jean-Paul Concordet and Saman Hosseinkhani. http://jcs.biologists.org/content/133/10/jcs242636?etoc

A small-molecule ARTS mimetic promotes apoptosis through degradation of both XIAP and Bcl-2Dana Mamriev, Ruqaia Abbas, Franca-Maria Klingler, Juliana Kagan, Nir Kfir, Alastair Donald, Keren Weidenfeld, David W. Sheppard, Dalit Barkan and Sarit Larisch. https://www.nature.com/articles/s41419-020-2670-2

XAF1 as a modifier of p53 function and cancer susceptibilityEmilia M. Pinto , Bonald C. Figueiredo, Wenan Chen […] Gang Wu, Gerard P. Zambetti. https://advances.sciencemag.org/content/6/26/eaba3231


Necroptosis and RIP kinases


MLKL trafficking and accumulation at the plasma membrane control the kinetics and threshold for necroptosisAndre L. Samson, Ying Zhang, Niall D. Geoghegan, Xavier J. Gavin, Katherine A. Davies, Michael J. Mlodzianoski, Lachlan W. Whitehead, Daniel Frank, Sarah E. Garnish, Cheree Fitzgibbon, Anne Hempel, Samuel N. Young, Annette V. Jacobsen, Wayne Cawthorne, Emma J. Petrie, Maree C. Faux, Kristy Shield-Artin, Najoua Lalaoui, Joanne M. Hildebrand, John Silke, Kelly L. Rogers, Guillaume Lessene, Edwin D. Hawkins and James M. Murphy. https://www.nature.com/articles/s41467-020-16887-1

Distinct pseudokinase domain conformations underlie divergent activation mechanisms among vertebrate MLKL orthologuesKatherine A. Davies, Cheree Fitzgibbon, Samuel N. Young, Sarah E. Garnish, Wayland Yeung, Diane Coursier, Richard W. Birkinshaw, Jarrod J. Sandow, Wil I. L. Lehmann, Lung-Yu Liang, Isabelle S. Lucet, James D. Chalmers, Wayne M. Patrick, Natarajan Kannan, Emma J. Petrie, Peter E. Czabotar and James M. Murphy. https://www.nature.com/articles/s41467-020-16823-3

RIPK3 upregulation confers robust proliferation and collateral cystine-dependence on breast cancer recurrenceChao-Chieh Lin, Nathaniel W. Mabe, Yi-Tzu Lin, Wen-Hsuan Yang, Xiaohu Tang, Lisa Hong, Tianai Sun, Jeremy Force, Jeffrey R. Marks, Tso-Pang Yao, James V. Alvarez and Jen-Tsan Chi. https://www.nature.com/articles/s41418-020-0499-y

Hepatocyte-specific TAK1 deficiency drives RIPK1 kinase-dependent inflammation to promote liver fibrosis and hepatocellular carcinomaShuixia Tan, Jing Zhao, Ziyu Sun, Shuangyi Cao, Kongyan Niu, Yedan Zhong, Han Wang, Linyu Shi, Heling Pan, Junhao Hu, Lihui Qian, Nan Liu, and Junying Yuan. https://www.pnas.org/content/117/25/14231.abstract?etoc


Pyroptosis


FDA-approved disulfiram inhibits pyroptosis by blocking gasdermin D pore formationJun Jacob Hu, Xing Liu, Shiyu Xia, Zhibin Zhang, Ying Zhang, Jingxia Zhao, Jianbin Ruan, Xuemei Luo, Xiwen Lou, Yang Bai, Junhong Wang, L. Robert Hollingsworth, Venkat Giri Magupalli, Li Zhao, Hongbo R. Luo, Justin Kim, Judy Lieberman and Hao Wu. https://www.nature.com/articles/s41590-020-0669-6

Induction of ASC pyroptosis requires gasdermin D or caspase-1/11-dependent mediators and IFNβ from pyroptotic macrophagesCuiping Zhang, Caiqi Zhao, Xiaoyan Chen, Rujia Tao, Sijiao Wang, Guangxun Meng, Xing Liu, Changzhou Shao and Xiao Su. https://www.nature.com/articles/s41419-020-2664-0

Extended subsite profiling of the pyroptosis effector protein gasdermin D reveals a region recognized by inflammatory caspase-11Betsaida Bibo-Verdugo, Scott J Snipas, Sonia Kolt, Marcin Poreba and Guy S Salvesen. http://www.jbc.org/content/early/2020/06/18/jbc.RA120.014259.abstract


Miscellanous


Senescence, Necrosis, and Apoptosis Govern Circulating Cell-free DNA Release KineticsAriana Rostami, Meghan Lambie, Caberry W. Yu, Vuk Stambolic, John N. Waldron, Scott V. Bratman. https://www.cell.com/cell-reports/fulltext/S2211-1247(20)30811-1

The anti-cancer drug ABTL0812 induces ER stress-mediated cytotoxic autophagy by increasing dihydroceramide levels in cancer cellsPau Muñoz-Guardiola, Josefina Casas, Elisabet Megías-Roda, Sònia Solé, Héctor Perez-Montoyo, Marc Yeste-Velasco, Tatiana Erazo, Nora Diéguez-Martínez, Sergio Espinosa-Gil, Cristina Muñoz-Pinedo, Guillermo Yoldi, Jose L Abad, Miguel F Segura, Teresa Mora, Margarita Romeo, Joaquim Bosch-Barrera, Ana Oaknin, Jose Alfón, Carles Domènech, Gemma Fabriàs, Guillermo Velasco and Jose M Lizcano. https://www.tandfonline.com/doi/full/10.1080/15548627.2020.1761651

Hexokinase II dissociation alone cannot account for changes in heart mitochondrial function, morphology and sensitivity to permeability transition pore opening following ischemiaGonçalo C Pereira, Laura Lee, Nadiia Rawlings, Joke Ouwendijk, Joanne E Parker, Tatyana N Andrienko, Jeremy M Henley, Andrew P Halestrap. https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0234653


Reviews


The clearance of dead cells by efferocytosisEmilio Boada-Romero, Jennifer Martinez, Bradlee L. Heckmann and Douglas R. Green. https://www.nature.com/articles/s41580-020-0232-1

Cell Death in the Origin and Treatment of CancerAndreas Strasser, David L. Vaux. https://www.cell.com/molecular-cell/fulltext/S1097-2765(20)30315-4

Noncanonical Cell Fate Regulation by Bcl-2 ProteinsStephen Jun Fei Chong, Saverio Marchi, Giulia Petroni, Guido Kroemer, Lorenzo Galluzzi, Shazib Pervaiz. https://www.cell.com/trends/cell-biology/fulltext/S0962-8924(20)30070-2

Photodynamic therapy: autophagy and mitophagy, apoptosis and paraptosisDavid Kessel and John J. Reiners. https://www.tandfonline.com/doi/abs/10.1080/15548627.2020.1783823

Uncovering the PIDDosome and caspase-2 as regulators of organogenesis and cellular differentiationValentina C. Sladky and Andreas Villunger. https://www.nature.com/articles/s41418-020-0556-6


Comments / other


Caspase-8 and FADD: Where Cell Death and Inflammation CollideMarcelo Pires Amaral, Karina Ramalho Bortoluci. https://www.cell.com/immunity/fulltext/S1074-7613(20)30216-8

Deadly Encounter: Endosomes Meet Mitochondria to Initiate ApoptosisMariella Vicinanza, David C. Rubinsztein. https://www.cell.com/developmental-cell/fulltext/S1534-5807(20)30419-6

Pyroptosis Takes Aim at NeurodevelopmentJaeda C. Coutinho-Budd, Heather T. Broihier. https://www.cell.com/developmental-cell/fulltext/S1534-5807(20)30402-0

Regulating RIPK1: another way in which ULK1 contributes to survivalWenxian Wu and Björn Stork. https://www.tandfonline.com/doi/full/10.1080/15548627.2020.1783110

MLKL contributes to Western diet-induced liver injury through inhibiting autophagyXiaoqin Wu and Laura E. Nagy. https://www.tandfonline.com/doi/abs/10.1080/15548627.2020.1760624

Cell death through the ages: The ICDS 25th Anniversary MeetingJarvier N. Mohammed, Jesse D. Gelles, Camila RubioPatiño, Madhavika N. Serasinghe, Andrew P. Trotta, Richard A. Lockshin, Zahra Zakeri, Jerry E. Chipuk. https://febs.onlinelibrary.wiley.com/doi/abs/10.1111/febs.15252

ApoList – May 2020


Bcl-2 family proteins


Identification of a Covalent Molecular Inhibitor of Anti-apoptotic BFL-1 by Disulfide Tethering – Edward P. Harvey, Zachary J. Hauseman, Daniel T. Cohen, T. Justin Rettenmaier, Susan Lee, Annissa J. Huhn, Thomas E. Wales, Hyuk-Soo Seo, James Luccarelli, Catherine E. Newman, Rachel M. Guerra, Gregory H. Bird, Sirano Dhe-Paganon, John R. Engen, James A. Wells, Loren D. Walensky. https://www.cell.com/cell-chemical-biology/fulltext/S2451-9456(20)30118-5?sf233998513=1

BCL-2 antagonism sensitizes cytotoxic T cell–resistant HIV reservoirs to elimination ex vivo – Yanqin Ren, Szu Han Huang, Shabnum Patel, Winiffer D. Conce Alberto, Dean Magat, Dughan Ahimovic, Amanda B. Macedo, Ryan Durga, Dora Chan, Elizabeth Zale, Talia M. Mota, Ronald Truong, Thomas Rohwetter, Chase D. McCann, Colin M. Kovacs, Erika Benko, Avery Wimpelberg, Christopher Cannon, W. David Hardy, Alberto Bosque, Catherine M. Bollard, and R. Brad Jones. https://www.jci.org/articles/view/132374


Death receptors


Quantitative single‐molecule imaging of TNFR1 reveals zafirlukast as antagonist of TNFR1 clustering and TNFα‐induced NF‐ĸB signaling – Nadine Weinelt, Christos Karathanasis, Sonja Smith, Juliane Medler, Sebastian Malkusch, Simone Fulda, Harald Wajant, Mike Heilemann, Sjoerd J. L. van Wijk. https://jlb.onlinelibrary.wiley.com/doi/10.1002/JLB.2AB0420-572RR#.XrvxctJyfu8.twitter

Doxorubicin sensitizes cancer cells to Smac mimetic via synergistic activation of the CYLD/RIPK1/FADD/caspase-8-dependent apoptosis – Chengkui Yang, Qiao Ran, Yifei Zhou, Shan Liu, Cong Zhao, Xiaoliang Yu, Fang Zhu, Yuting Ji, Qian Du, Tao Yang, Wei Zhang and Sudan He. https://link.springer.com/article/10.1007/s10495-020-01604-6


Caspases


Non-Canonical Caspase Activity Antagonizes p38 MAPK Stress-Priming Function to Support Development – Benjamin P. Weaver, Yi M. Weaver, Shizue Omi, Wang Yuan, Jonathan J. Ewbank, Min Han. https://www.cell.com/developmental-cell/fulltext/S1534-5807(20)30224-0

Leishmania aethiopica cell‐to‐cell spreading involves caspase‐3, AkT, and NF‐κB but not PKC‐δ activation and involves uptake of LAMP‐1‐positive bodies containing parasites – Medhavi Ranatunga, Rajeev Rai, Simon C. W. Richardson, Paul Dyer, Laurence Harbige, Andrew Deacon, Lauren Pecorino, Giulia T. M. Getti. https://febs.onlinelibrary.wiley.com/doi/abs/10.1111/febs.15166

Involvement of CASP9 (caspase 9) in IGF2R/CI-MPR endosomal transport – Jie Han, Leslie A. Goldstein, Wen Hou, Simon C. Watkins and Hannah Rabinowich. https://www.tandfonline.com/doi/abs/10.1080/15548627.2020.1761742


Necroptosis


The death-inducing activity of RIPK1 is regulated by the pH environment – Kenta Moriwaki , Sakthi Balaji, Francis Ka-Ming Chan. https://stke.sciencemag.org/content/13/631/eaay7066

Crucial Roles of the RIP Homotypic Interaction Motifs of RIPK3 in RIPK1-Dependent Cell Death and Lymphoproliferative Disease – Haiwei Zhang, Xiaoxia Wu, Xiaoming Li, Ming Li, Fang Li, Lingxia Wang, Xixi Zhang, Yue Zhang, Yan Luo, Hui Wang, Yiguo Jiang, Haibing Zhang. https://www.cell.com/cell-reports/fulltext/S2211-1247(20)30603-3

The Zα2 domain of ZBP1 is a molecular switch regulating influenza-induced PANoptosis and perinatal lethality during development – Sannula Kesavardhana, R. K. Subbarao Malireddi, Amanda R Burton, Shaina N Porter, Peter Vogel, Shondra M Pruett-Miller and Thirumala-Devi Kanneganti. http://www.jbc.org/content/early/2020/04/29/jbc.RA120.013752.abstract

Attenuated Epigenetic Suppression of Muscle Stem Cell Necroptosis Is Required for Efficient Regeneration of Dystrophic Muscles – Krishnamoorthy Sreenivasan, Alessandro Ianni, Carsten Künne, Boris Strilic, Stefan Günther, Eusebio Perdiguero, Marcus Krüger, Simone Spuler, Stefan Offermanns, Pablo Gómez-del Arco, Juan Miguel Redondo, Pura Munoz-Canoves, Johnny Kim, Thomas Braun. https://www.cell.com/cell-reports/fulltext/S2211-1247(20)30605-7


Pyroptosis


Granzyme A from cytotoxic lymphocytes cleaves GSDMB to trigger pyroptosis in target cells – Zhiwei Zhou, Huabin He, Kun Wang, Xuyan Shi, Yupeng Wang, Ya Su, Yao Wang, Da Li, Wang Liu, Yongliang Zhang, Lianjun Shen, Weidong Han, Lin Shen, Jingjin Ding, Feng Shao. https://science.sciencemag.org/content/368/6494/943?utm


Miscellanous


Zika virus noncoding RNA suppresses apoptosis and is required for virus transmission by mosquitoes – Andrii Slonchak, Leon E. Hugo, Morgan E. Freney, Sonja Hall-Mendelin, Alberto A. Amarilla, Francisco J. Torres, Yin Xiang Setoh, Nias Y. G. Peng, Julian D. J. Sng, Roy A. Hall, Andrew F. van den Hurk, Gregor J. Devine and Alexander A. Khromykh. https://www.nature.com/articles/s41467-020-16086-y

CXCR1 and CXCR2 Chemokine Receptor Agonists Produced by Tumors Induce Neutrophil Extracellular Traps that Interfere with Immune CytotoxicityÁlvaro Teijeira, Saray Garasa, María Gato, Carlos Alfaro, Itziar Migueliz, Assunta Cirella, Carlos de Andrea, Maria Carmen Ochoa, Itziar Otano, Iñaki Etxeberria, Maria Pilar Andueza, Celia P. Nieto, Leyre Resano, Arantza Azpilikueta, Marcello Allegretti, Maria de Pizzol, Mariano Ponz-Sarvisé, Ana Rouzaut, Miguel F. Sanmamed, Kurt Schalper, Michael Carleton, Mario Mellado, María E. Rodriguez-Ruiz, Pedro Berraondo, Jose L. Perez-Gracia, Ignacio Melero. https://www.cell.com/immunity/fulltext/S1074-7613(20)30089-3


Reviews


BCL-2 family deregulation in colorectal cancer: potential for BH3 mimetics in therapy – Prashanthi Ramesh and Jan Paul Medema. https://link.springer.com/article/10.1007/s10495-020-01601-9

Emerging Mechanisms and Disease Relevance of Ferroptosis – Brent R. Stockwell, Xuejun Jiang, Wei Gu. https://www.cell.com/trends/cell-biology/fulltext/S0962-8924(20)30054-4

BAX inhibitor‐1: between stress and survival – Cynthia Lebeaupin, Marina Blanc, Déborah Vallée, Harald Keller, Béatrice Bailly‐Maitre. https://febs.onlinelibrary.wiley.com/doi/abs/10.1111/febs.15179

The emerging role of paraptosis in tumor cell biology: Perspectives for cancer prevention and therapy with natural compoundsFabrizio Fontana, Michela Raimondi, Monica Marzagalli, Alessandro Di Domizio, Patrizia Limonta. https://www.sciencedirect.com/science/article/abs/pii/S0304419X19301945

Caspase-8: The double-edged sword – Ranadip Mandal, Joan Compte Barrón, Izabela Kostova, Sven Becker, Klaus Strebhardt. https://www.sciencedirect.com/science/article/abs/pii/S0304419X19301763

New insights into the regulation of apoptosis, necroptosis, and pyroptosis by receptor interacting protein kinase 1 and caspase-8Robin Schwarzer, Lucie Laurien, Manolis Pasparakis. https://www.sciencedirect.com/science/article/abs/pii/S0955067420300272?dgcid=raven_sd_via_email

The Role of Caspase-2 in Regulating Cell Fate – Vasanthy Vigneswara and Zubair Ahmed. https://www.mdpi.com/2073-4409/9/5/1259

Inhibition of Anti-Apoptotic Bcl-2 Proteins in Preclinical and Clinical Studies: Current Overview in CancerSimona D’Aguanno and Donatella Del Bufalo. https://www.mdpi.com/2073-4409/9/5/1287

Tumour Cell Secretome in Chemoresistance and Tumour Recurrence – Emma C. Madden, Adrienne M. Gorman, Susan E. Logue, Afshin Samali. https://www.cell.com/trends/cancer/fulltext/S2405-8033(20)30081-9

Novel Forms of Immunomodulation for Cancer TherapyAlfonso Serrano-del Valle, Javier Naval, Alberto Anel, Isabel Marzo. https://www.cell.com/trends/cancer/fulltext/S2405-8033(20)30076-5

Cysteine Depletion, a Key Action to Challenge Cancer Cells to Ferroptotic Cell Death – Daher B, Vučetić M, Pouysségur J. https://www.frontiersin.org/articles/10.3389/fonc.2020.00723/full

SnapShot: Ferroptosis – Kamyar Hadian, Brent R. Stockwell. https://www.cell.com/cell/fulltext/S0092-8674(20)30504-3


Comments


Development or Disease: Caspases Balance Growth and Immunity in C. elegans – Olya Yarychkivska, Shai Shaham. https://www.cell.com/developmental-cell/fulltext/S1534-5807(20)30273-2

Killer cells add fire to fuel immunotherapy – Christopher J. Nicolai, David H. Raulet. https://science.sciencemag.org/content/368/6494/943

ApoList – April 2020


Bcl-2 family proteins


Separase-triggered apoptosis enforces minimal length of mitosis – Susanne Hellmuth, Olaf Stemmann. https://www.nature.com/articles/s41586-020-2187-y

The apoptosis inhibitor Bcl-xL controls breast cancer cell migration through mitochondria-dependent reactive oxygen species production – Margaux Bessou, Jonathan Lopez, Rudy Gadet, Mathieu Deygas, Nikolay Popgeorgiev, Delphine Poncet, Adrien Nougarède, Pauline Billard, Ivan Mikaelian, Philippe Gonzalo, Ruth Rimokh and Germain Gillet. https://www.nature.com/articles/s41388-020-1212-9

Melanoma-specific bcl-2 promotes a protumoral M2-like phenotype by tumor-associated macrophagesMarta Di Martile, Valentina Farini, Francesca Maria Consonni, Daniela Trisciuoglio, Marianna Desideri, Elisabetta Valentini, Simona D’Aguanno, Maria Grazia Tupone, Simonetta Buglioni, Cristiana Ercolani, Enzo Gallo, Bruno Amadio, Irene Terrenato, Maria Laura Foddai, Antonio Sica and Donatella Del Bufalo. https://jitc.bmj.com/content/8/1/e000489

Loss of BIM in T cells results in BCL-2 family BH3-member compensation but incomplete cell death sensitivity normalization – Lindsey M. Ludwig, Lauren E. Roach, Samuel G. Katz and James L. LaBelle. https://link.springer.com/article/10.1007/s10495-020-01593-6

Inhibition of BCL2 Family Members Increases the Efficacy of Copper Chelation in BRAFV600E-Driven Melanoma – Ye-Jin Kim, Tiffany Tsang, Grace R. Anderson, Jessica M. Posimo and Donita C. Brady. https://cancerres.aacrjournals.org/content/80/7/1387

Monocytic Subclones Confer Resistance to Venetoclax-Based Therapy in Patients with Acute Myeloid Leukemia – Shanshan Pei, Daniel A. Pollyea, Annika Gustafson, Brett M. Stevens, Mohammad Minhajuddin, Rui Fu, Kent A. Riemondy, Austin E. Gillen, Ryan M. Sheridan, Jihye Kim, James C. Costello, Maria L. Amaya, Anagha Inguva, Amanda Winters, Haobin Ye, Anna Krug, Courtney L. Jones, Biniam Adane, Nabilah Khan, Jessica Ponder, Jeffrey Schowinsky, Diana Abbott, Andrew Hammes, Jason R. Myers, John M. Ashton, Travis Nemkov, Angelo D’Alessandro, Jonathan A. Gutman, Haley E. Ramsey, Michael R. Savona, Clayton A. Smith and Craig T. Jordan. https://cancerdiscovery.aacrjournals.org/content/10/4/536

The senotherapeutic drug ABT-737 disrupts aberrant p21 expression to restore liver regeneration in adult mice – Birgit Ritschka, Tania Knauer-Meyer, Daniel Sampaio Gonçalves, Alba Mas, Jean-Luc Plassat, Matej Durik, Hugues Jacobs, Elisa Pedone, Umberto Di Vicino, Maria Pia Cosma and William M. Keyes. http://genesdev.cshlp.org/content/34/7-8/489.abstract?etoc


Death receptors


Impaired Death Receptor Signaling in Leukemia Causes Antigen-Independent Resistance by Inducing CAR T-cell Dysfunction – Nathan Singh, Yong Gu Lee, Olga Shestova, Pranali Ravikumar, Katharina E. Hayer, Seok Jae Hong, Xueqing Maggie Lu, Raymone Pajarillo, Sangya Agarwal, Shunichiro Kuramitsu, Elena J. Orlando, Karen Thudium Mueller, Charly R. Good, Shelley L. Berger, Ophir Shalem, Matthew D. Weitzman, Noelle V. Frey, Shannon L. Maude, Stephan A. Grupp, Carl H. June, Saar Gill and Marco Ruella. https://cancerdiscovery.aacrjournals.org/content/10/4/552

Blocking the death checkpoint protein TRAIL improves cardiac function after myocardial infarction in monkeys, pigs, and rats – Yaohui Wang , Hailong Zhang, Zhizeng Wang, Yinxiang Wei, Mingli Wang, Meichen Liu, Xuance Wang, Yinan Jiang, Gongning Shi, Dongmei Zhao, Zhengyan Yang, Zhiguang Ren, Jing Li, Zhenkai Zhang, Zhenfeng Wang, Bei Zhang, Beibei Zong, Xueke Lou, Chengguo Liu, Zihui Wang, Hao Zhang, Ningya Tao, Xuefang Li, Xingkun Zhang, Yafei Guo, Yang Ye, Yu Qi, Hui Li, Man Wang, Rongxin Guo, Guanchang Cheng, Shulian Li, Jun Zhang, Guangchao Liu, Lihui Chai, Qiang Lou, Xia Li, Xiukun Cui, Erhe Gao, Zheng Dong, Yanzhong Hu, Youhai H. Chen, Yuanfang Ma. https://stm.sciencemag.org/content/12/540/eaaw3172

A Two-Cell Model for IL-1β Release Mediated by Death-Receptor Signaling – Carlos A. Donado, Anh B. Cao, Daimon P. Simmons, Ben A. Croker, Patrick J. Brennan, Michael B. Brenner. https://www.cell.com/cell-reports/fulltext/S2211-1247(20)30344-2

Dynamic Fas signaling network regulates neural stem cell proliferation and memory enhancement – Seokhwi Kim , Nury Kim, Jinsu Lee, Sungsoo Kim, Jongryul Hong, Seungkyu Son, Won Do Heo. https://advances.sciencemag.org/content/6/17/eaaz9691


Necroptosis and RIP kinases


Identification of MLKL membrane translocation as a checkpoint in necroptotic cell death using Monobodies – Emma J. Petrie, Richard W. Birkinshaw, Akiko Koide, Eric Denbaum, Joanne M. Hildebrand, Sarah E. Garnish, Katherine A. Davies, Jarrod J. Sandow, Andre L. Samson, Xavier Gavin, Cheree Fitzgibbon, Samuel N. Young, Patrick J. Hennessy, Phoebe P. C. Smith, Andrew I. Webb, Peter E. Czabotar, Shohei Koide, and James M. Murphy. https://www.pnas.org/content/117/15/8468.abstract?etoc

The Autophagy-Initiating Kinase ULK1 Controls RIPK1-Mediated Cell Death – Wenxian Wu, Xiaojing Wang, Niklas Berleth, Jana Deitersen, Nora Wallot-Hieke, Philip Böhler, David Schlütermann, Fabian Stuhldreier, Jan Cox, Katharina Schmitz, Sabine Seggewiß, Christoph Peter, Gary Kasof, Anja Stefanski, Kai Stühler, Astrid Tschapek, Axel Gödecke, Björn Stork. https://www.cell.com/cell-reports/fulltext/S2211-1247(20)30457-5

Autophosphorylation at serine 166 regulates RIP kinase 1-mediated cell death and inflammation – Lucie Laurien, Masahiro Nagata, Hannah Schünke, Tom Delanghe, Janica L. Wiederstein, Snehlata Kumari, Robin Schwarzer, Teresa Corona, Marcus Krüger, Mathieu J. M. Bertrand, Vangelis Kondylis and Manolis Pasparakis. https://www.nature.com/articles/s41467-020-15466-8


Caspases / Pyroptosis


Caspase-6 Is a Key Regulator of Innate Immunity, Inflammasome Activation, and Host Defense – Min Zheng, Rajendra Karki, Peter Vogel, Thirumala-Devi Kanneganti. https://www.cell.com/cell/fulltext/S0092-8674(20)30333-0

A Two-Cell Model for IL-1β Release Mediated by Death-Receptor Signaling – Carlos A. Donado, Anh B. Cao, Daimon P. Simmons, Ben A. Croker, Patrick J. Brennan, Michael B. Brenner. https://www.cell.com/cell-reports/fulltext/S2211-1247(20)30344-2


Ferroptosis


Cysteine depletion induces pancreatic tumor ferroptosis in mice – Michael A. Badgley, Daniel M. Kremer, H. Carlo Maurer, Kathleen E. DelGiorno, Ho-Joon Lee, Vinee Purohit, Irina R. Sagalovskiy, Alice Ma, Jonathan Kapilian, Christina E. M. Firl, Amanda R. Decker, Steve A. Sastra, Carmine F. Palermo, Leonardo R. Andrade, Peter Sajjakulnukit, Li Zhang, Zachary P. Tolstyka, Tal Hirschhorn, Candice Lamb, Tong Liu, Wei Gu, E. Scott Seeley, Everett Stone, George Georgiou, Uri Manor, Alina Iuga, Geoffrey M. Wahl, Brent R. Stockwell, Costas A. Lyssiotis, Kenneth P. Olive. https://science.sciencemag.org/content/368/6486/85

MDM2 and MDMX promote ferroptosis by PPARα-mediated lipid remodeling – Divya Venkatesh, Nicholas A. O’Brien, Fereshteh Zandkarimi, David R. Tong, Michael E. Stokes, Denise E. Dunn, Everett S. Kengmana, Allegra T. Aron, Alyssa M. Klein, Joleen M. Csuka, Sung-Hwan Moon, Marcus Conrad, Christopher J. Chang, Donald C. Lo, Angelo D’Alessandro, Carol Prives and Brent R. Stockwell. http://genesdev.cshlp.org/content/34/7-8/526.abstract?etoc


Miscellanous


Cell death induced by cytotoxic CD8+ T cells is immunogenic and primes caspase-3–dependent spread immunity against endogenous tumor antigensPaula Jaime-Sanchez, Iratxe Uranga-Murillo, Nacho Aguilo, Sofia C Khouili, Maykel A Arias, David Sancho, Julian Pardo. https://jitc.bmj.com/content/8/1/e000528

Cellular cytotoxicity is a form of immunogenic cell deathLuna Minute, Alvaro Teijeira, Alfonso R Sanchez-Paulete, Maria C Ochoa, Maite Alvarez, Itziar Otano, Iñaki Etxeberrria, Elixabet Bolaños, Arantza Azpilikueta, Saray Garasa, Noelia Casares, Jose Luis Perez Gracia, Maria E Rodriguez-Ruiz, Pedro Berraondo and Ignacio Melero. https://jitc.bmj.com/content/8/1/e000325

A nonpeptidyl molecule modulates apoptosis-like cell death by inhibiting P. falciparum metacapase-2 – Vandana, Sudha Shankar, Kona Madhavinadha Prasad, Mohammad Kashif, Inderjeet Kalia, Rajkishor Rai, Agam P. Singh, Kailash C. Pandey. https://portlandpress.com/biochemj/article-abstract/477/7/1323/222446/

Starvation and antimetabolic therapy promote cytokine release and recruitment of immune cells – Franziska Püschel, Francesca Favaro, Jaime Redondo-Pedraza, Estefanía Lucendo, Raffaella Iurlaro, Sandrine Marchetti, Blanca Majem, Eric Eldering, Ernest Nadal, Jean-Ehrland Ricci, Eric Chevet, and Cristina Muñoz-Pinedo. https://www.pnas.org/content/early/2020/04/17/1913707117/


Reviews


Controlling Cell Death through Post-translational Modifications of DED Proteins – Kamil Seyrek, Nikita V. Ivanisenko, Max Richter, Laura K. Hillert, Corinna König, Inna N. Lavrik. https://www.cell.com/trends/cell-biology/fulltext/S0962-8924(20)30041-6

An unexpected turn of fortune: targeting TRAIL-Rs in KRAS-driven cancer – Silvia von Karstedt and Henning Walczak. https://www.nature.com/articles/s41420-020-0249-4

Stress Management: Death Receptor Signalling and Cross-Talks with the Unfolded Protein Response in Cancer – Elodie Lafont. https://www.mdpi.com/2072-6694/12/5/1113

Cell-Free DNA and Apoptosis: How Dead Cells Inform About the Living – Ellen Heitzer, Lisa Auinger, Michael R. Speicher. https://www.cell.com/trends/molecular-medicine/fulltext/S1471-4914(20)30040-X

Consensus guidelines for the definition, detection and interpretation of immunogenic cell death – Lorenzo Galluzzi, Ilio Vitale, Sarah Warren, Sandy Adjemian, Patrizia Agostinis, Aitziber Buqué Martinez, Timothy A Chan, George Coukos, Sandra Demaria, Eric Deutsch, Dobrin Draganov, Richard L Edelson, Silvia C Formenti, Jitka Fucikova, Lucia Gabriele, Udo S Gaipl, Sofia R Gameiro, Abhishek D Garg, Encouse Golden, Jian Han, Kevin J Harrington, Akseli Hemminki, James W Hodge, Dewan Md Sakib Hossain, Tim Illidge, Michael Karin, Howard L Kaufman, Oliver Kepp, Guido Kroemer, Juan Jose Lasarte, Sherene Loi, Michael T Lotze, Gwenola Manic, Taha Merghoub, Alan A Melcher, Karen L Mossman, Felipe Prosper, Øystein Rekdal, Maria Rescigno, Chiara Riganti, Antonella Sistigu, Mark J Smyth, Radek Spisek, John Stagg, Bryan E Strauss, Daolin Tang, Kazuki Tatsuno, Stefaan W van Gool, Peter Vandenabeele, Takahiro Yamazaki, Dmitriy Zamarin, Laurence Zitvogel, Alessandra Cesano, Francesco M Marincola. https://jitc.bmj.com/content/8/1/e000337

A20 and Cell Death-driven InflammationDario Priem, Geert van Loo, Mathieu J.M. Bertrand. https://www.cell.com/trends/immunology/fulltext/S1471-4906(20)30039-9#.XoiGl7hWlh0.twitter

Necroptosis and its role in infectious diseases – Xiaojing Xia, Liancheng Lei, Song Wang, Jianhe Hu and Gaiping Zhang. https://link.springer.com/article/10.1007/s10495-019-01589-x

Dark Side of Cytotoxic Therapy: Chemoradiation-Induced Cell Death and Tumor Repopulation – Ming-jie Jiang, Dian-na Gu, Juan-juan Dai, Qian Huang, Ling Tian. https://www.cell.com/trends/cancer/fulltext/S2405-8033(20)30057-1

Caspases in Cell Death, Inflammation, and Pyroptosis – Sannula Kesavardhana, R.K. Subbarao Malireddi, and Thirumala-Devi Kanneganti. https://www.annualreviews.org/doi/abs/10.1146/annurev-immunol-073119-095439

Book series at International Review of Cell and Molecular Biology: Cell Death Regulation in Health and Disease

Preface: Life through death—Key role of cellular suicide for colonial and organismal homeostasis – Johan Spetz, Lorenzo Galluzzi. https://www.sciencedirect.com/science/article/pii/S1937644820300356

Chapter One – Bcl-2 family proteins, beyond the veil – Jason Andrew Glab, Zhipeng Cao, Hamsa Puthalakath. https://www.sciencedirect.com/science/article/pii/S1937644819301200

Chapter Two – Mcl-1 as a “barrier” in cancer treatment: Can we target it now? – Nikolay V. Pervushin, Viacheslav V. Senichkin, Boris Zhivotovsky, Gelina S. Kopeina. https://www.sciencedirect.com/science/article/pii/S1937644820300022

Chapter Three – TRAIL receptor signaling: From the basics of canonical signal transduction toward its entanglement with ER stress and the unfolded protein response – Daniela Stöhr, Albert Jeltsch, Markus Rehm. https://www.sciencedirect.com/science/article/pii/S1937644820300071

Chapter Four – Type 3 IP3 receptors: The chameleon in cancer – Nicolas Rosa, Flore Sneyers, Jan B. Parys, Geert Bultynck. https://www.sciencedirect.com/science/article/pii/S1937644820300083

Chapter Five – On the role of sphingolipids in cell survival and death – Elisabetta Iessi, Matteo Marconi, Valeria Manganelli, Maurizio Sorice, … Paola Matarrese. https://www.sciencedirect.com/science/article/pii/S1937644820300095

Chapter Six – A lipid perspective on regulated cell death – Hector Flores-Romero, Uris Ros, Ana J. García-Sáez. https://www.sciencedirect.com/science/article/pii/S1937644819301170 

Part B

Chapter One – The mechanisms and cell signaling pathways of programmed cell death in the bacterial world – Robert P. Smith, Ivana Barraza, Rebecca J. Quinn, Marla C. Fortoul. https://doi.org/10.1016/bs.ircmb.2019.12.002

Chapter Two – Transcriptional and epigenetic control of regulated cell death in yeast – Andreas Zimmermann, Jelena Tadic, Katharina Kainz, Sebastian J. Hofer, … Frank Madeo. https://doi.org/10.1016/bs.ircmb.2019.12.003

Chapter Three – Cell death in the avian brain with emphasis on the development and plasticity of the song control system – Tracy A. Larson. https://doi.org/10.1016/bs.ircmb.2020.01.001

Chapter Four – Crosstalk between apoptosis and autophagy signaling pathways – W. Douglas Fairlie, Sharon Tran, Erinna F. Lee. https://doi.org/10.1016/bs.ircmb.2020.01.003

Chapter Five – The interplay of autophagy and non-apoptotic cell death pathways – Dannah R. Miller, Scott D. Cramer, Andrew Thorburn. https://doi.org/10.1016/bs.ircmb.2019.12.004

Chapter Six – Redox signaling in the pathogenesis of human disease and the regulatory role of autophagy – Shazib Pervaiz, Gregory L. Bellot, Antoinette Lemoine, Catherine Brenner. https://doi.org/10.1016/bs.ircmb.2020.03.002

Part C

Chapter One – Poly (ADP-ribose) (PAR)-dependent cell death in neurodegenerative diseases – Hyejin Park, Tae-In Kam, Ted M. Dawson, Valina L. Dawson. https://doi.org/10.1016/bs.ircmb.2019.12.009

Chapter Two – Molecular mechanisms of necroptosis and relevance for neurodegenerative diseases – Pedro A. Dionísio, Joana D. Amaral, Cecília M.P. Rodrigues. https://doi.org/10.1016/bs.ircmb.2019.12.006

Chapter Three – Necroptosis, ADAM proteases and intestinal (dys)function – Michelle Heib, Stefan Rose-John, Dieter Adam. https://doi.org/10.1016/bs.ircmb.2020.02.001

Chapter Four – Regulation of cell death in the cardiovascular system – Pooja Patel, Jason Karch. https://doi.org/10.1016/bs.ircmb.2019.11.005

Chapter Five – The involvement of regulated cell death forms in modulating the bacterial and viral pathogenesis – Gergely Imre. https://doi.org/10.1016/bs.ircmb.2019.12.008

Chapter Six – A connection in life and death: The BCL-2 family coordinates mitochondrial network dynamics and stem cell fate – Megan L. Rasmussen, Vivian Gama. https://doi.org/10.1016/bs.ircmb.2019.12.005


Comments


Not So FASt: Tumor Cells Resisting Death Drive CAR T-cell Dysfunction – Michael R. Green and Sattva S. Neelapu. https://cancerdiscovery.aacrjournals.org/content/10/4/492

Immunogenicity of cell death driven by immune effectorsLorenzo Galluzzi, Giulia Petroni, Guido Kroemer. https://jitc.bmj.com/content/8/1/e000802

Programmed death, cells on the last train to glory – Patrycja Nowak-Sliwinska and Arjan W. Griffioen. https://link.springer.com/article/10.1007/s10495-020-01598-1

ApoList – March 2020

Research is important. Keep strong everyone

 


Death receptors


TRAIL Receptors Serve as Stress-Associated Molecular Patterns to Promote ER-Stress-Induced Inflammation – Graeme P. Sullivan, Hazel O’Connor, Conor M. Henry, Pavel Davidovich, Danielle M. Clancy, Matthew L. Albert, Sean P. Cullen, Seamus J. Martin. https://www.cell.com/developmental-cell/fulltext/S1534-5807(20)30063-0

A20 Promotes Ripoptosome Formation and TNF-Induced Apoptosis via cIAPs Regulation and NIK Stabilization in Keratinocytes – Maria Feoktistova, Roman Makarov, Sihem Brenji, Anne T. Schneider, Guido J. Hooiveld, Tom Luedde, Martin Leverkus, Amir S. Yazdi and Diana Panayotova-Dimitrova. https://www.mdpi.com/2073-4409/9/2/351

Targeting the Extrinsic Pathway of Hepatocyte Apoptosis Promotes Clearance of Plasmodium Liver Infection – Gregor Ebert, Sash Lopaticki, Matthew T. O’Neill, Ryan W.J. Steel, Marcel Doerflinger, Pravin Rajasekaran, Annie S.P. Yang, Sara Erickson, Lisa Ioannidis, Philip Arandjelovic, Liana Mackiewicz, Cody Allison, John Silke, Marc Pellegrini, Justin A. Boddey. https://www.cell.com/cell-reports/fulltext/S2211-1247(20)30346-6


Caspases and cFLIP


Cancer Cells Employ Nuclear Caspase-8 to Overcome the p53-Dependent G2/M Checkpoint through Cleavage of USP28 – Ines Müller, Elwira Strozyk, Sebastian Schindler, Stefan Beissert, Htoo Zarni Oo, Thomas Sauter, Philippe Lucarelli, Sebastian Raeth, Angelika Hausser, Nader Al Nakouzi, Ladan Fazli, Martin E. Gleave, He Liu, Hans-Uwe Simon, Henning Walczak, Douglas R. Green, Jiri Bartek, Mads Daugaard, Dagmar Kulms. https://www.cell.com/molecular-cell/fulltext/S1097-2765(19)30953-0

Cross-regulation between LUBAC and caspase-1 modulates cell death and inflammation – Todd Douglas and Maya Saleh. http://www.jbc.org/content/early/2020/03/02/jbc.RA119.011622.abstract


Gastermins and pyroptosis


Gasdermin E suppresses tumour growth by activating anti-tumour immunity – Zhibin Zhang, Ying Zhang, Shiyu Xia, Qing Kong, Shunying Li, Xing Liu, Caroline Junqueira, Karla F. Meza-Sosa, Temy Mo Yin Mok, James Ansara, Satyaki Sengupta, Yandan Yao, Hao Wu and Judy Lieberman. https://www.nature.com/articles/s41586-020-2071-9

cFLIPL protects macrophages from LPS-induced pyroptosis via inhibition of complex II formation – Hayley I. Muendlein, David Jetton, Wilson M. Connolly, Keith P. Eidell, Zoie Magri, Irina Smirnova, Alexander Poltorak. https://science.sciencemag.org/content/367/6484/1379

A bioorthogonal system reveals antitumour immune function of pyroptosis – Qinyang Wang, Yupeng Wang, Jingjin Ding, Chunhong Wang, Xuehan Zhou, Wenqing Gao, Huanwei Huang, Feng Shao and Zhibo Liu. https://www.nature.com/articles/s41586-020-2079-1

Structural Mechanism for GSDMD Targeting by Autoprocessed Caspases in Pyroptosis – Kun Wang, Qi Sun, Xiu Zhong, Mengxue Zeng, Huan Zeng, Xuyan Shi, Zilin Li, Yupeng Wang, Qiang Zhao, Feng Shao, Jingjin Ding. https://www.cell.com/cell/fulltext/S0092-8674(20)30146-X

Mitochondrial GSDMD Pores DAMPen Pyroptosis – Katherine C. Barnett, Jenny P.-Y. Ting. https://www.cell.com/immunity/fulltext/S1074-7613(20)30083-2

mtDNA Activates cGAS Signaling and Suppresses the YAP-Mediated Endothçelial Cell Proliferation Program to Promote Inflammatory Injury – Long Shuang Huang, Zhigang Hong, Wei Wu, Shiqin Xiong, Ming Zhong, Xiaopei Gao, Jalees Rehman, Asrar B. Malik. https://www.cell.com/immunity/fulltext/S1074-7613(20)30083-2

A bioorthogonal system reveals antitumour immune function of pyroptosis – Qinyang Wang, Yupeng Wang, Jingjin Ding, Chunhong Wang, Xuehan Zhou, Wenqing Gao, Huanwei Huang, Feng Shao and Zhibo Liu. https://www.nature.com/articles/s41586-020-2079-1


Bcl-2 family proteins


A small-molecule allosteric inhibitor of BAX protects against doxorubicin-induced cardiomyopathy – Dulguun Amgalan, Thomas P. Garner, Ryan Pekson, Xiaotong F. Jia, Mounica Yanamandala, Victor Paulino, Felix G. Liang, J. Jose Corbalan, Jaehoon Lee, Yun Chen, George S. Karagiannis, Luis Rivera Sanchez, Huizhi Liang, Swathi-Rao Narayanagari, Kelly Mitchell, Andrea Lopez, Victoria Margulets, Marco Scarlata, Gaetano Santulli, Aarti Asnani, Randall T. Peterson, Rachel B. Hazan, John S. Condeelis, Maja H. Oktay, Ulrich Steidl, Lorrie A. Kirshenbaum, Evripidis Gavathiotis and Richard N. Kitsis. https://www.nature.com/articles/s43018-020-0039-1

Site-Dependent Cysteine Lipidation Potentiates the Activation of Proapoptotic BAX – Daniel T. Cohen, Thomas E. Wales, Matthew W. McHenry, John R. Engen, Loren D. Walensky. https://www.cell.com/cell-reports/fulltext/S2211-1247(20)30225-4

Low expression of pro-apoptotic proteins Bax, Bak and Smac indicates prolonged progression-free survival in chemotherapy-treated metastatic melanoma – Cristiano Guttà, Arman Rahman, Claudia Aura, Peter Dynoodt, Emilie M. Charles, Elodie Hirschenhahn, Jesuchristopher Joseph, Jasper Wouters, Ciaran de Chaumont, Mairin Rafferty, Madhuri Warren, Joost J. van den Oord, William M. Gallagher and Markus Rehm. https://www.nature.com/articles/s41419-020-2309-3

SFTSV Infection Induces BAK/BAX-Dependent Mitochondrial DNA Release to Trigger NLRP3 Inflammasome Activation – Shufen Li, Hao Li, Yu-Lan Zhang, Qi-Lin Xin, Zhen-Qiong Guan, Xi Chen, Xiao-Ai Zhang, Xiao-Kun Li, Geng-Fu Xiao, Pierre-Yves Lozach, Jun Cui, Wei Liu, Lei-Ke Zhang, Ke Peng. https://www.cell.com/cell-reports/fulltext/S2211-1247(20)30286-2

Combined reduction in the expression of MCL-1 and BCL-2 reduces organismal size in mice – Francine Ke, Graeme I. Lancaster, Stephanie Grabow, Andrew J. Murphy and Andreas Strasser. https://www.nature.com/articles/s41419-020-2376-5

MCL1 is Required for Maintenance of Intestinal Homeostasis and Prevention of Carcinogenesis in Mice – Marc E. Healy, Yannick Boege, Michael C. Hodder, Friederike Böhm, Mohsen Malehmir, Anna-Lena Scherr, Jasna Jetzer, Lap Kwan Chan, Rossella Parrotta, Kurt Jacob, Laure-Alix Clerbaux, Susanne Kreutzer, Andrew Campbell, Ella Gilchrist, Kathryn Gilroy, Ann-Katrin Rodewal , Hanna Honcharova-Biletska, Roman Schimmer, Karelia Vélez, Simone Büeler, Patrizia Cammareri , Gabriela Kalna, Anna S. Wenning, Kathy D. McCoy, Mercedes Gomez de Agüero, Henning Schulze-Bergkamen, Christoph Klose, Kristian Unger, Andrew J. Macpherson , Andreas E. Moor, Bruno Köhler, Owen J. Sanso, Mathias Heikenwalder, Achim Weber. https://www.gastrojournal.org/article/S0016-5085(20)30338-3/fulltext

HUWE1 controls MCL1 stability to unleash AMBRA1-induced mitophagyFlavie Strappazzon, Anthea Di Rita, Angelo Peschiaroli, Pier Paolo Leoncini, Franco Locatelli, Gerry Melino and Francesco Cecconi. https://www.nature.com/articles/s41418-019-0404-8

MCL1 binding to the reverse BH3 motif of P18INK4C couples cell survival to cell proliferation – Robert H. Whitaker and William J. Placzek. https://www.nature.com/articles/s41419-020-2351-1

MCL1 inhibition is effective against a subset of small-cell lung cancer with high MCL1 and low BCL-XL expression – Yuto Yasuda, Hiroaki Ozasa, Young Hak Kim, Masatoshi Yamazoe, Hitomi Ajimizu, Tomoko Yamamoto Funazo, Takashi Nomizo, Takahiro Tsuji, Hironori Yoshida, Yuichi Sakamori, Naoki Nakajima, Toshi Menju, Akihiko Yoshizawa, Hiroshi Date and Toyohiro Hirai. https://www.nature.com/articles/s41419-020-2379-2

Conformational Switching in Bcl-xL: Enabling Non-Canonic Inhibition of Apoptosis Involves Multiple Intermediates and Lipid Interactions – Victor Vasquez-Montes, Alexander Kyrychenko, Mauricio Vargas-Uribe, Mykola V. Rodnin and Alexey S. Ladokhin. https://www.mdpi.com/2073-4409/9/3/539

Electron transport chain activity is a predictor and target for venetoclax sensitivity in multiple myeloma – Richa Bajpai, Aditi Sharma, Abhinav Achreja, Claudia L. Edgar, Changyong Wei, Arusha A. Siddiqa, Vikas A. Gupta, Shannon M. Matulis, Samuel K. McBrayer, Anjali Mittal, Manali Rupji, Benjamin G. Barwick, Sagar Lonial, Ajay K. Nooka, Lawrence H. Boise, Deepak Nagrath and Mala Shanmugam. https://www.nature.com/articles/s41467-020-15051-z


Necroptosis


Sequential activation of necroptosis and apoptosis cooperates to mediate vascular and neural pathology in stroke – Masanori Gomi Naito, Daichao Xu, Palak Amin, Jinwoo Lee, Huibing Wang, Wanjin Li, Michelle Kelliher, Manolis Pasparakis, and Junying Yuan. https://www.pnas.org/content/117/9/4959.abstract?etoc

Z-nucleic-acid sensing triggers ZBP1-dependent necroptosis and inflammation – Huipeng Jiao, Laurens Wachsmuth, Snehlata Kumari, Robin Schwarzer, Juan Lin, Remzi Onur Eren, Amanda Fisher, Rebecca Lane, George R. Young, George Kassiotis, William J. Kaiser and Manolis Pasparakis. https://www.nature.com/articles/s41586-020-2129-8

Gut stem cell necroptosis by genome instability triggers bowel inflammation – Ruicong Wang, Hongda Li, Jianfeng Wu, Zhi-Yu Cai, Baizhou Li, Hengxiao Ni, Xingfeng Qiu, Hui Chen, Wei Liu, Zhang-Hua Yang, Min Liu, Jin Hu, Yaoji Liang, Ping Lan, Jiahuai Han and Wei Mo. https://www.nature.com/articles/s41586-020-2127-x

Inhibition of keratinocyte necroptosis mediated by RIPK1/RIPK3/MLKL provides a protective effect against psoriatic inflammation – Xiaoru Duan, Xinxin Liu, Nian Liu, Yuqiong Huang, Zilin Jin, Song Zhang, Zhangyin Ming and Hongxiang Chen. https://www.nature.com/articles/s41419-020-2328-0

Necroptosis-blocking compound NBC1 targets heat shock protein 70 to inhibit MLKL polymerization and necroptosis – Andrea N. Johnston, Yuyong Ma, Hua Liu, Shuzhen Liu, Sarah Hanna-Addams, She Chen, Chuo Chen and Zhigao Wang. https://www.pnas.org/content/117/12/6521.abstract?etoc

Influenza Virus Z-RNAs Induce ZBP1-Mediated Necroptosis – Ting Zhang, Chaoran Yin, David F. Boyd, Giovanni Quarato, Justin P. Ingram, Maria Shubina, Katherine B. Ragan, Takumi Ishizuka, Jeremy Chase Crawford, Bart Tummers, Diego A. Rodriguez, Jia Xue, Suraj Peri, William J. Kaiser, Carolina B. López, Yan Xu, Jason W. Upton, Paul G. Thomas, Douglas R. Green, Siddharth Balachandran. https://www.cell.com/cell/fulltext/S0092-8674(20)30227-0

The necroptosis machinery mediates axonal degeneration in a model of Parkinson diseaseMaritza Oñate, Alejandra Catenaccio, Natalia Salvadores, Cristian Saquel, Alexis Martinez, Ines Moreno-Gonzalez, Nazaret Gamez, Paulina Soto, Claudio Soto, Claudio Hetz and Felipe A. Court. https://www.nature.com/articles/s41418-019-0408-4


Ferroptosis


Transferrin Receptor Is a Specific Ferroptosis Marker – Huizhong Feng, Kenji Schorpp, Jenny Jin, Carrie E. Yozwiak, Benjamin G. Hoffstrom, Aubrianna M. Decker, Presha Rajbhandari, Michael E. Stokes, Hannah G. Bender, Joleen M. Csuka, Pavan S. Upadhyayula, Peter Canoll, Koji Uchida, Rajesh K. Soni, Kamyar Hadian, Brent R. Stockwell. https://www.cell.com/cell-reports/fulltext/S2211-1247(20)30210-2

Mitochondrial DNA stress triggers autophagy-dependent ferroptotic death – Li C, Zhang Y, Liu J, Kang R, Klionsky DJ, Tang D. https://www.tandfonline.com/doi/full/10.1080/15548627.2020.1739447

Caspase-1 interdomain linker cleavage is required for pyroptosis – Daniel P Ball, Cornelius Y Taabazuing, Andrew R Griswold, Elizabeth L Orth, Sahana D Rao, Ilana B Kotliar, Lauren E Vostal, Darren C Johnson and Daniel A Bachovchin. https://www.life-science-alliance.org/content/3/3/e202000664.abstract


Efferocytosis and cell-cell effects


Metabolites released from apoptotic cells act as tissue messengers – Christopher B. Medina, Parul Mehrotra, Sanja Arandjelovic, Justin S. A. Perry, Yizhan Guo, Sho Morioka, Brady Barron, Scott F. Walk, Bart Ghesquière, Alexander S. Krupnick, Ulrike Lorenz and Kodi S. Ravichandran. https://www.nature.com/articles/s41586-020-2121-3

Macrophage Metabolism of Apoptotic Cell-Derived Arginine Promotes Continual Efferocytosis and Resolution of Injury – Arif Yurdagul Jr., Manikandan Subramanian, Xiaobo Wang, Scott B. Crown, Olga R. Ilkayeva, Lancia Darville, Gopi K. Kolluru, Christina C. Rymond, Brennan D. Gerlach, Ze Zheng, George Kuriakose, Christopher G. Kevil, John M. Koomen, John L. Cleveland, Deborah M. Muoio, Ira Tabas. https://www.sciencedirect.com/science/article/abs/pii/S1550413120300012


Miscellanous


In vivo detection of programmed cell death during mouse heart development – Kristel Martínez-Lagunas, Yoshifumi Yamaguchi, Cora Becker, Caroline Geisen, Marco C. DeRuiter, Masayuki Miura, Bernd K. Fleischmann and Michael Hesse. https://www.nature.com/articles/s41418-019-0426-2


Reviews


Classification and Nomenclature of Metacaspases and Paracaspases: No More Confusion with Caspases – Elena A. Minina, Jens Staal, Vanina E. Alvarez, John A. Berges, Ilana Berman-Frank, Rudi Beyaert, Kay D. Bidle, Frédéric Bornancin, Magali Casanova, Juan J. Cazzulo, Chang Jae Choi, Nuria S. Coll, Vishva M. Dixit, Marko Dolinar, Nicolas Fasel, Christiane Funk, Patrick Gallois, Kris Gevaert, Emilio Gutierrez-Beltran, Stephan Hailfinger, Marina Klemenčič, Eugene V. Koonin, Daniel Krappmann, Anna Linusson, Maurício F.M. Machado, Frank Madeo, Lynn A. Megeney, Panagiotis N. Moschou, Jeremy C. Mottram, Thomas Nyström, Heinz D. Osiewacz, Christopher M. Overall, Kailash C. Pandey, Jürgen Ruland, Guy S. Salvesen, Yigong Shi, Andrei Smertenko, Simon Stael, Jerry Ståhlberg, María Fernanda Suárez, Margot Thome, Hannele Tuominen, Frank Van Breusegem, Renier A.L. van der Hoorn, Assaf Vardi, Boris Zhivotovsky, Eric Lam, Peter V. Bozhkov. https://www.cell.com/molecular-cell/fulltext/S1097-2765(19)30950-5

Investigating Nonapoptotic Cell Death Using Chemical Biology Approaches – David A. Armenta, Scott J. Dixon. https://www.cell.com/cell-chemical-biology/fulltext/S2451-9456(20)30079-9

Ferroptosis: past, present and future – Jie Li, Feng Cao, He-liang Yin, Zi-jian Huang, Zhi-tao Lin, Ning Mao, Bei Sun and Gang Wang. https://www.nature.com/articles/s41419-020-2298-2

Restoring Apoptosis with BH3 Mimetics in Mature B-Cell Malignancies – Maxime Jullien, Patricia Gomez-Bougie, David Chiron and Cyrille Touzeau. https://www.mdpi.com/2073-4409/9/3/717


Comments


Ghostly metabolic messages from dying cells – Douglas R. Green. https://www.nature.com/articles/d41586-020-00641-0

ER Stress Leaves an Inflammatory TRAIL – Alba Roca Portoles, Stephen W.G. Tait. https://www.cell.com/developmental-cell/fulltext/S1534-5807(20)30188-X

Appetite for Arginine: Metabolic Control of Macrophage Hunger – Daniel J. Puleston, Erika L. Pearce. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(20)30064-4

TAMing efferocytosis to fight tumors – Christopher B. Rodell. https://stm.sciencemag.org/content/12/533/eabb0795

Destroying tumors with pyroptosis – John F. Foley. https://stke.sciencemag.org/content/13/624/eabb8244