May 2, 2023 cris

ApoList – April 2023

Bcl-2 family proteins

The carboxyl-terminal sequence of PUMA binds to both anti-apoptotic proteins and membranes – James M Pemberton, Dang Nguyen, Elizabeth J Osterlund, Wiebke Schormann, Justin P Pogmore, Nehad Hirmiz, Brian Leber, David W Andrews. https://elifesciences.org/articles/88329

Lymphoma cells lacking pro-apoptotic BAX are highly resistant to BH3-mimetics targeting pro-survival MCL-1 but retain sensitivity to conventional DNA-damaging drugs – Sarah T. Diepstraten, Savannah Young, John E. La Marca, Zilu Wang, Ruth M. Kluck, Andreas Strasser and Gemma L. Kelly. https://www.nature.com/articles/s41418-023-01117-0

Death receptors

XIAP deletion sensitizes mice to TNF-induced and RIP1-mediated death – Axel Witt, Tatiana Goncharov, Yujung Michelle Lee, Matthias Kist, Monika Dohse, Jeff Eastham, Debra Dugger, Kim Newton, Joshua D. Webster and Domagoj Vucic. https://www.nature.com/articles/s41419-023-05793-1

Therapeutic efficacy of a MMAE-based anti-DR5 drug conjugate Oba01 in preclinical models of pancreatic cancer – Chao Zheng, Dongdong Zhou, Weisong Li, Yanhui Duan, Minwen Xu, Jie Liu, Jingpei Cheng, Youban Xiao, Han Xiao, Tao Gan, Jianmin Liang, Dexian Zheng, Liefeng Wang and Shuyong Zhang. https://www.nature.com/articles/s41419-023-05820-1

Caspases

Caspase-8 is required for HSV-1-induced apoptosis and promotes effective viral particle release via autophagy inhibition – Francesca Marino-Merlo, Anusha Klett, Emanuela Papaianni, Selene Francesca Anna Drago, Beatrice Macchi, María Gabriela Rincón, Federica Andreola, Annalucia Serafino, Sandro Grelli, Antonio Mastino and Christoph Borner. https://www.nature.com/articles/s41418-022-01084-y

Necroptosis

RIPK3 promoter hypermethylation in hepatocytes protects from bile acid-induced inflammation and necroptosis – Jessica Hoff, Ling Xiong, Tobias Kammann, Sophie Neugebauer, Julia M. Micheel, Nikolaus Gaßler, Michael Bauer and Adrian T. Press. https://www.nature.com/articles/s41419-023-05794-0

MLKL deficiency protects against low-grade, sterile inflammation in aged mice – Emma C. Tovey Crutchfield, Sarah E. Garnish, Jessica Day, Holly Anderton, Shene Chiou, Anne Hempel, Cathrine Hall, Komal M. Patel, Pradnya Gangatirkar, Katherine R. Martin, Connie S. N. Li Wai Suen, Alexandra L. Garnham, Andrew J. Kueh, Ian P. Wicks, John Silke, Ueli Nachbur, Andre L. Samson, James M. Murphy and Joanne M. Hildebrand. https://www.nature.com/articles/s41418-023-01121-4

Pyroptosis

Distinct GSDMB protein isoforms and protease cleavage processes differentially control pyroptotic cell death and mitochondrial damage in cancer cells – Sara S. Oltra, Sara Colomo, Laura Sin, María Pérez-López, Sara Lázaro, Angela Molina-Crespo, Kyoung-Han Choi, David Ros-Pardo, Lidia Martínez, Saleta Morales, Cristina González-Paramos, Alba Orantes, Mario Soriano, Alberto Hernández, Ana Lluch, Federico Rojo, Joan Albanell, Paulino Gómez-Puertas, Jae-Kyun Ko, David Sarrió and Gema Moreno-Bueno. https://www.nature.com/articles/s41418-023-01143-y

Alternative splicing of GSDMB modulates killer lymphocyte-triggered pyroptosis – Qing Kong, Shiyu Xia, Xingxin Pan, Kaixiong Ye, Zhouyihan Li, Haoyan Li, Xiaoqiang Tang, Nidhi Sahni, S. Stephen Yi, Xing Liu, Hao Wu, Michael B. Elowitz, Judy Lieberman, Zhibin Zhang. https://www.science.org/doi/10.1126/sciimmunol.adg3196

USP48 Stabilizes Gasdermin E to Promote Pyroptosis in Cancer – Yidan Ren, Maoxiao Feng, Xiaodong Hao, Xiaoyan Liu, Juan Li, Peilong Li, Jie Gao, Qiuchen Qi, Lutao Du, Chuanxin Wang, Qin Wang, Yunshan Wang. https://aacrjournals.org/cancerres/article-abstract/83/7/1074/718998

Ferroptosis

Lipid peroxidation increases membrane tension, Piezo1 gating, and cation permeability to execute ferroptosis – Yusuke Hirata, Ruiqi Cai, Allen Volchuk, Benjamin E. Steinberg, Yoshiro Saito, Atsushi Matsuzawa, Sergio Grinstein, Spencer A. Freeman. https://www.cell.com/current-biology/fulltext/S0960-9822(23)00200-2

Efferocytosis, entosis etc

An Unexpected Role of Neutrophils in Clearing Apoptotic Hepatocytes In Vivo – Luyang Cao, Lixiang Ma, Juan Zhao, Xiangyu Wang, Xinzou Fan, Wei Li, Yawen Qi, Yingkui Tang, Jieya Liu, Shengxian PengLi YangLiangxue ZhouLi Li, Xiaobo Hu, Yuan Ji, Yingyong Hou, Yi Zhao, Xianming Zhang, Youyang Zhao, Yong Zhao, Yuquan Wei, Asrar B. Malik, Hexige Saiyin, J ingsong Xu. https://elifesciences.org/reviewed-preprints/86591

Miscellanous

Quantifying requirements for mitochondrial apoptosis in CAR T killing of cancer cells – Alexandra L. Pourzia, Michael L. Olson, Stefanie R. Bailey, Angela C. Boroughs, Aditi Aryal, Jeremy Ryan, Marcela V. Maus and Anthony Letai. https://www.nature.com/articles/s41419-023-05727-x

Live-cell imaging and mathematical analysis of the “community effect” in apoptosis – Diane Coursier, David Coulette, Hélène Leman, Emmanuel Grenier, Gabriel Ichim. https://link.springer.com/article/10.1007/s10495-022-01783-4

Reviews

Apoptosis: a Janus bifrons in T-cell immunotherapy – Yong Gu Lee, Nicholas Yang, Inkook Chun, Patrizia Porazzi, Alberto Carturan, Luca Paruzzo, Christopher Tor Sauter, Puneeth Guruprasad, Raymone Pajarillo and Marco Ruella. https://jitc.bmj.com/content/11/4/e005967

Cell death, therapeutics, and the immune response in cancer – Kay Hänggi, Brian Ruffell. https://www.cell.com/trends/cancer/fulltext/S2405-8033(23)00021-3

To not love thy neighbor: mechanisms of cell competition in stem cells and beyond – Marianna Yusupova and Yaron Fuchs. https://www.nature.com/articles/s41418-023-01114-3

Ferroptosis: A flexible constellation of related biochemical mechanisms – Scott J. Dixon, Derek A. Pratt. https://www.cell.com/molecular-cell/fulltext/S1097-2765(23)00162-4

Caspases help to spread the message via extracellular vesicles – Claire Hill, Elizabeth R. Dellar, Luis Alberto Baena-Lopez. https://febs.onlinelibrary.wiley.com/doi/full/10.1111/febs.16418

Comments

LC3-independent autophagy is vital to prevent TNF cytotoxicity – Dario Priem, Jon Huyghe and Mathieu JM Bertrand. https://www.tandfonline.com/doi/abs/10.1080/15548627.2023.2197760

Ferroptosis: Under pressure! – Adam Wahida, Marcus Conrad. https://www.cell.com/current-biology/fulltext/S0960-9822(23)00297-X

Lysosomal lipid peroxidation mediates immunogenic cell death – Pravin Phadatare and Jayanta Debnath. https://www.jci.org/articles/view/169240

Sayonara to some evolutionary puzzles in the Bcl‐2 family – Kristin White. https://www.embopress.org/doi/full/10.15252/embj.2023113980

The road to death: Caspases, cleavage, and pores – Vishva M. Dixit. https://www.science.org/doi/full/10.1126/sciadv.adi2011

Editor Profile: Ana García Sáez – https://febs.onlinelibrary.wiley.com/doi/full/10.1111/febs.16732

April 3, 2023 cris

ApoList – March 2023

Pore-forming proteins

Norovirus MLKL-like protein initiates cell death to induce viral egress – Guoxun Wang, Di Zhang, Robert C. Orchard, Dustin C. Hancks and Tiffany A. Reese. https://www.nature.com/articles/s41586-023-05851-w

Structural basis for GSDMB pore formation and its targeting by IpaH7.8 – Chengliang Wang, Sonia Shivcharan, Tian Tian, Skylar Wright, Danyang Ma, JengYih Chang, Kunpeng Li, Kangkang Song, Chen Xu, Vijay A. Rathinam and Jianbin Ruan. https://www.nature.com/articles/s41586-023-05832-z

Structural mechanisms for regulation of GSDMB pore-forming activity – Xiu Zhong, Huan Zeng, Zhiwei Zhou, Ya Su, Hang Cheng, Yanjie Hou, Yang She, Na Feng, Jia Wang, Feng Shao and Jingjin Ding. https://www.nature.com/articles/s41586-023-05872-5

More pore-forming proteins – Bcl-2 family

Visualization of BOK pores independent of BAX and BAK reveals a similar mechanism with differing regulation – Raed Shalaby, Arzoo Diwan, Hector Flores-Romero, Vanessa Hertlein and Ana J. Garcia-Saez. https://www.nature.com/articles/s41418-022-01078-w

Mitochondrial E3 ubiquitin ligase MARCHF5 controls BAK apoptotic activity independently of BH3-only proteins – Allan Shuai Huang, Hui San Chin, Boris Reljic, Tirta M. Djajawi, Iris K. L. Tan, Jia-Nan Gong, David A. Stroud, David C. S. Huang, Mark F. van Delft and Grant Dewson. https://www.nature.com/articles/s41418-022-01067-z

A BAK subdomain that binds mitochondrial lipids selectively and releases cytochrome C – Haiming Dai, Kevin L. Peterson, Karen S. Flatten, X. Wei Meng, Annapoorna Venkatachalam, Cristina Correia, Marina Ramirez-Alvarado, Yuan-Ping Pang and Scott H. Kaufmann. https://www.nature.com/articles/s41418-022-01083-z

Synthetic lethality of drug-induced polyploidy and BCL-2 inhibition in lymphoma – Ana Portelinha, Mariana da Silva Ferreira, Tatiana Erazo, Man Jiang, Zahra Asgari, Elisa de Stanchina, Anas Younes and Hans-Guido Wendel. https://www.nature.com/articles/s41467-023-37216-2

Post-MOMP events

Executioner caspases restrict mitochondrial RNA-driven Type I IFN induction during chemotherapy-induced apoptosis – Shane T. Killarney, Rachel Washart, Ryan S. Soderquist, Jacob P. Hoj, Jamie Lebhar, Kevin H. Lin and Kris C. Wood. https://www.nature.com/articles/s41467-023-37146-z

Apoptotic cell fragments locally activate tingible body macrophages in the germinal center – Abigail K. Grootveld, Wunna Kyaw, Veera Panova, Angelica W.Y. Lau, Emily Ashwin, Guillaume Seuzaret, Rama Dhenni, Nayan Deger Bhattacharyya, Weng Hua Khoo, Maté Biro, Tanmay Mitra, Michael Meyer-Hermann, Patrick Bertolino, Masato Tanaka, David A. Hume, Peter I. Croucher, Robert Brink, Akira Nguyen, Oliver Bannard, Tri Giang Phan. https://www.cell.com/cell/fulltext/S0092-8674(23)00106-X

F-actin-rich territories coordinate apoptosome assembly and caspase activation during DNA damage-induced intrinsic apoptosis – Virginia L King, and Kenneth G Campellone. https://www.molbiolcell.org/doi/abs/10.1091/mbc.E22-04-0119

Death receptors

Breast tumors interfere with endothelial TRAIL at the premetastatic niche to promote cancer cell seeding – Carla Riera-Domingo, Eduarda Leite-Gomes, Iris Charatsidou, Peihua Zhao, Giovanna Carrá, Federica Cappellesso, Larissa Mourao, Maxim De Schepper, Dana Liu, Jens Serneels, Mohamad-Gabriel Alameh, Vladimir V. Shuvaev, Tatjana Geukens, Edoardo Isnaldi, Hans Prenen, Drew Weissman, Vladimir R. Muzykantov, Stefaan Soenen, Christine Desmedt, Colinda L. G. J. Scheele, Anna Sablina, Mario Di Matteo, Rosa Martín-Pérez, Massimiliano Mazzone. https://www.science.org/doi/full/10.1126/sciadv.add5028

Inhibition of multiple CDKs potentiates colon cancer chemotherapy via p73-mediated DR5 induction – Jingshan Tong, Xiao Tan, Suisui Hao, Kaylee Ermine, Xinyan Lu, Zhaojin Liu, Anupma Jha, Jian Yu and Lin Zhang. https://www.nature.com/articles/s41388-023-02598-6

Miscellanous

Blebs promote cell survival by assembling oncogenic signalling hubs – Andrew D. Weems, Erik S. Welf, Meghan K. Driscoll, Felix Y. Zhou, Hanieh Mazloom-Farsibaf, Bo-Jui Chang, Vasanth S. Murali, Gabriel M. Gihana, Byron G. Weiss, Joseph Chi, Divya Rajendran, Kevin M. Dean, Reto Fiolka and Gaudenz Danuser. https://www.nature.com/articles/s41586-023-05758-6

Actin cytoskeleton vulnerability to disulfide stress mediates disulfidptosis – Xiaoguang Liu, Litong Nie, Yilei Zhang, Yuelong Yan, Chao Wang, Medina Colic, Kellen Olszewski, Amber Horbath, Xiong Chen, Guang Lei, Chao Mao, Shiqi Wu, Li Zhuang, Masha V. Poyurovsky, M. James You, Traver Hart, Daniel D. Billadeau, Junjie Chen and Boyi Gan. https://www.nature.com/articles/s41556-023-01091-2

SMAC mimetics inhibit human T cell proliferation and fail to augment type 1 cytokine responses – Ashley M Burton, Brittany R Ligman, Claire A Kearney, Susan E Murray. https://www.sciencedirect.com/science/article/abs/pii/S0008874923000138?via%3Dihub

Reviews

Mitochondrial pores at the crossroad between cell death and inflammatory signaling – Hector Flores-Romero, Shashank Dadsena, Ana J. García-Sáez. https://www.cell.com/molecular-cell/fulltext/S1097-2765(23)00124-7

Comments

A massive machine regulates cell death – Peter D. Mace and Catherine L. Day. https://www.science.org/doi/abs/10.1126/science.adg9605

Deadly actin collapse by disulfidptosis – Laura M. Machesky. https://www.nature.com/articles/s41556-023-01100-4

March 7, 2023 cris

ApoList – February 2023

Efferocytosis, entosis etc

Senescent cells suppress macrophage-mediated corpse removal via upregulation of the CD47-QPCT/L axis – Daniela Schloesser, Laura Lindenthal, Julia Sauer, Kyoung-Jin Chung, Triantafyllos Chavakis, Eva Griesser, Praveen Baskaran, Ulrike Maier-Habelsberger, Katrin Fundel-Clemens, Ines Schlotthauer, Carolin Kirsten Watson, Lee Kim Swee, Frederik Igney, John Edward Park, Markus S. Huber-Lang, Matthew-James Thomas, Karim Christian El Kasmi, Peter J. Murray. https://rupress.org/jcb/article/222/2/e202207097/213731

Inhomogeneous mechanotransduction defines the spatial pattern of apoptosis-induced compensatory proliferation – Takumi Kawaue, Ivan Yow, Yuping Pan, Anh Phuong Le, Yuting Lou, Mavis Loberas, Murat Shagirov, Xiang Teng, Jacques Prost, Tetsuya Hiraiwa, Benoit Ladoux, Yusuke Toyama. https://www.cell.com/developmental-cell/fulltext/S1534-5807(23)00036-9

Immunogenicity

Cellular Senescence Is Immunogenic and Promotes Antitumor Immunity – Ines Marin, Olga Boix, Andrea Garcia-Garijo, Isabelle Sirois, Adrià Caballe, Eduardo Zarzuela, Irene Ruano, Camille Stephan-Otto Attolini, Neus Prats, José A López-Domínguez, Marta Kovatcheva, Elena Garralda, Javier Muñoz, Etienne Caron, María Abad, Alena Gros, Federico Pietrocola, Manuel Serrano. https://aacrjournals.org/cancerdiscovery/article/13/2/410/716304

Senescence Rewires Microenvironment Sensing to Facilitate Antitumor Immunity – Hsuan-An Chen, Yu-Jui Ho, Riccardo Mezzadra, Jose M. Adrover, Ryan Smolkin, Changyu Zhu, Katharina Woess, Nicholas Bernstein, Georgia Schmitt, Linda Fong, Wei Luan, Alexandra Wuest, Sha Tian, Xiang Li, Caroline Broderick, Ronald C. Hendrickson, Mikala Egeblad, Zhenghao Chen, Direna Alonso-Curbelo, Scott W. Lowe. https://aacrjournals.org/cancerdiscovery/article/13/2/432/716311

Senescent cancer cell vaccines induce cytotoxic T cell responses targeting primary tumors and disseminated tumor cells – Yue Liu, Joanna Pagacz, Donald J Wolfgeher, Kenneth D Bromerg, Jacob V Gorman and Stephen J Kron. https://jitc.bmj.com/content/11/2/e005862

Bcl-2 family proteins

Peptides from human BNIP5 and PXT1 and non-native binders of pro-apoptotic BAK can directly activate or inhibit BAK-mediated membrane permeabilization – Aguilar F, Yu S, Grant RA, Swanson S, Ghose D, Su BG, Sarosiek KA, Keating AE. https://www.cell.com/structure/fulltext/S0969-2126(23)00001-1

Death receptors

Negligible role of TRAIL death receptors in cell death upon endoplasmic reticulum stress in B-cell malignancies – Francesca Favaro, Demi Both, Ingrid A. M. Derks, Marcel Spaargaren, Cristina Muñoz-Pinedo and Eric Eldering. https://www.nature.com/articles/s41389-023-00450-w

Autoinhibitory structure of preligand association state implicates a new strategy to attain effective DR5 receptor activation – Gang Du, Linlin Zhao, Yumei Zheng, Anissa Belfetmi, Tiantian Cai, Boying Xu, Karen Heyninck, Kim Van Den Heede, Marie-Ange Buyse, Pietro Fontana, Michael Bowman, Lih-Ling Lin, Hao Wu and James Jeiwen Chou. https://www.nature.com/articles/s41422-022-00755-2

TSC2 regulates tumor susceptibility to TRAIL‐mediated T‐cell killing by orchestrating mTOR signaling – Chun-Pu Lin, Joleen J H Traets, David W Vredevoogd, Nils L Visser, Daniel S Peeper. https://www.embopress.org/doi/abs/10.15252/embj.2022111614

Caspases and IAPs

Caspase-8 as a novel mediator linking Src kinase signaling to enhanced glioblastoma malignancy – Claudia Contadini, Alessandra Ferri, Marta Di Martile, Claudia Cirotti, Donatella Del Bufalo, Francesca De Nicola, Matteo Pallocca, Maurizio Fanciulli, Francesca Sacco, Gloria Donninelli, Alessia Capone, Elisabetta Volpe, Nadine Keller, Shunichiro Miki, Daisuke Kawauchi, Dwayne Stupack, Frank Furnari and Daniela Barilà. https://www.nature.com/articles/s41418-022-01093-x

Conserved folding landscape of monomeric initiator caspases – Mithun Nag, A. Clay Clark. https://www.jbc.org/article/S0021-9258(23)00207-7/fulltext

Structural basis for regulation of apoptosis and autophagy by the BIRC6/SMAC complex – Julian F. Ehrmann, Daniel B. Grabarczyk, Maria Heinke, Luiza Deszcz, Robert Kurzbauer, Otto Hudecz, Alexandra Shulkina, Rebeca Gogova, Anton Meinhart, Gijs A. Versteeg, Tim Clausen. https://www.science.org/doi/abs/10.1126/science.ade8873

Structural basis for SMAC-mediated antagonism of caspase inhibition by the giant ubiquitin ligase BIRC6 – Larissa Dietz, Cara J. Ellison, Carlos Riechmann, C. Keith Cassidy, F. Daniel Felfoldi, Adán Pinto-Fernández, Benedikt M. Kessler, Paul R. Elliott. https://www.science.org/doi/abs/10.1126/science.ade8840

Structures of BIRC6-client complexes provide a mechanism of Smac-mediated release of caspases – Moritz Hunkeler, Cyrus Y. Jin, Eric S. Fischer. https://www.science.org/doi/abs/10.1126/science.ade5750

Necroptosis and asssociated signals

Telomere-to-mitochondria signalling by ZBP1 mediates replicative crisis – Joe Nassour, Lucia Gutierrez Aguiar, Adriana Correia, Tobias T. Schmidt, Laura Mainz, Sara Przetocka, Candy Haggblom, Nimesha Tadepalle, April Williams, Maxim N. Shokhirev, Semih C. Akincilar, Vinay Tergaonkar, Gerald S. Shadel and Jan Karlseder. https://www.nature.com/articles/s41586-023-05710-8

Pyroptosis

Caspase‐8‐driven apoptotic and pyroptotic crosstalk causes cell death and IL‐1β release in X‐linked inhibitor of apoptosis (XIAP) deficiency – Sebastian A Hughes, Meng Lin, Ashley Weir, Bing Huang, Liya Xiong, Ngee Kiat Chua, Jiyi Pang, Jascinta P Santavanond, Rochelle Tixeira, Marcel Doerflinger, Yexuan Deng, Chien-Hsiung Yu, Natasha Silke, Stephanie A Conos, Daniel Frank, Daniel S Simpson, James M Murphy, Kate E Lawlor, Jaclyn S Pearson, John Silke, Marc Pellegrini, Marco J Herold, Ivan K H Poon, Seth L Masters, Mingsong Li, Qin Tang, Yuxia Zhang, Maryam Rashidi, Lanlan Geng, James E Vince. https://www.embopress.org/doi/abs/10.15252/embj.2021110468

Elevated Methionine Flux Drives Pyroptosis Evasion in Persister Cancer Cells – Asmaa El-Kenawi, Anders Berglund, Veronica Estrella, Yonghong Zhang, Min Liu, Ryan M. Putney, Sean J. Yoder, Joseph Johnson, Joel Brown, Robert Gatenby. https://aacrjournals.org/cancerres/article/83/5/720/716681

Reviews

BCL-2 protein family: attractive targets for cancer therapy – Deeksha Kaloni, Sarah T Diepstraten, Andreas Strasser, Gemma L Kelly. https://link.springer.com/article/10.1007/s10495-022-01780-7

Drosophila caspases as guardians of host-microbe interactions – Christa Kietz and Annika Meinander. https://www.nature.com/articles/s41418-022-01038-4

Harnessing TRAIL-induced cell death for cancer therapy: a long walk with thrilling discoveries – Antonella Montinaro and Henning Walczak. https://www.nature.com/articles/s41418-022-01059-z

Immunogenic cell death in cancer: concept and therapeutic implications – Lorenzo Galluzzi, Oliver Kepp, Erik Hett, Guido Kroemer and Francesco M. Marincola. https://translational-medicine.biomedcentral.com/articles/10.1186/s12967-023-04017-6

Sub-lethal signals in the mitochondrial apoptosis apparatus: pernicious by-product or physiological event? – Georg Häcker and Aladin Haimovici. https://www.nature.com/articles/s41418-022-01058-0

When cell death goes wrong: inflammatory outcomes of failed apoptosis and mitotic cell death – Florian J. Bock and Joel S. Riley. https://www.nature.com/articles/s41418-022-01082-0

Cell death and inflammation during obesity: “Know my methods, WAT(son)” – Ximena Hildebrandt, Mohamed Ibrahim and Nieves Peltzer. https://www.nature.com/articles/s41418-022-01062-4

Cellular senescence: beneficial, harmful, and highly complex – Darren J. Baker, Masashi Narita, Pura Muñoz-Cánoves

Special issue: https://febs.onlinelibrary.wiley.com/toc/17424658/2023/290/5

Comments / other

When aging gets on the way of disposal: Senescent cell suppression of efferocytosis – Carla V. Rothlin, Sourav Ghosh. https://rupress.org/jcb/article/222/2/e202212023/213792

Death receptor 5 rises to the occasion – Lixin Zheng, Yikun Yao and Michael J. Lenardo. https://www.nature.com/articles/s41422-022-00772-1

Apoptosis, autophagy, and cancer: the critical role Genes & Development played in paradigm shifts – Eileen White. http://genesdev.cshlp.org/content/37/1-2/59.extract?etoc

Senescent Cancer Cells Are Vulnerable to Extrinsic Apoptosis Pathway Activation. https://aacrjournals.org/cancerdiscovery/article-abstract/13/2/256/716286

February 3, 2023 cris

ApoList – January 23

Caspases

Cell survival following direct executioner-caspase activation – Maddalena Nano, James A. Mondo, Jacob Harwood, Varuzhan Balasanyan and Denise J. Montell. https://www.pnas.org/doi/10.1073/pnas.2216531120

Endothelial Caspase-8 prevents fatal necroptotic hemorrhage caused by commensal bacteria – Stefanie M. Bader, Simon P. Preston, Katie Saliba, Adam Lipszyc, Zoe L. Grant, Liana Mackiewicz, Andrew Baldi, Anne Hempel, Michelle P. Clark, Thanushi Peiris, William Clow, Jan Bjelic, Michael D. Stutz, Philip Arandjelovic, Jack Teale, Fashuo Du, Leigh Coultas, James M. Murphy, Cody C. Allison, Marc Pellegrini and Andre L. Samson. https://www.nature.com/articles/s41418-022-01042-8

Role of Caspase-10-P13tBID axis in erythropoiesis regulation – Mathilde Lamarque, Emilie-Fleur Gautier, François Rodrigues, Flavia Guillem, Elisa Bayard, Cédric Broussard, Thiago Maciel Trovati, Jean-Benoît Arlet, Patrick Mayeux, Olivier Hermine and Geneviève Courtois. https://www.nature.com/articles/s41418-022-01066-0

X‐linked inhibitor of apoptosis protein represents a promising therapeutic target for relapsed/refractory ALL – Michela Carlet, Karin Schmelz, Jenny Vergalli, Tobias Herold, Daniela Senft, Vindi Jurinovic, Thomas Hoffmann, Jutta Proba, Nina Weichert, Christian Junghanß, Mareike Roth, Georg Eschenburg, Malwine Barz, Günter Henze, Cornelia Eckert, Angelika Eggert, Johannes Zuber, Patrick Hundsdoerfer, Irmela Jeremias. https://www.embopress.org/doi/full/10.15252/emmm.202114557

Caspase-9 driven murine model of selective cell apoptosis and efferocytosis – Lena Batoon, Amy J. Koh, Rahasudha Kannan, Laurie K. McCauley and Hernan Roca. https://www.nature.com/articles/s41419-023-05594-6

Bcl-2 family proteins

Co-targeting BCL-XL and MCL-1 with DT2216 and AZD8055 synergistically inhibit small-cell lung cancer growth without causing on-target toxicities in mice – Sajid Khan, Patrick Kellish, Nick Connis, Dinesh Thummuri, Janet Wiegand, Peiyi Zhang, Xuan Zhang, Vivekananda Budamagunta, Nan Hua, Yang Yang, Umasankar De, Lingtao Jin, Weizhou Zhang, Guangrong Zheng, Robert Hromas, Christine Hann, Maria Zajac-Kaye, Frederic J. Kaye and Daohong Zhou. https://www.nature.com/articles/s41420-022-01296-8

Evidence for existence of an apoptosis-inducing BH3-only protein, sayonara, in Drosophila – Yuko Ikegawa, Christophe Combet, Mathieu Groussin, Vincent Navratil, Sabrina Safar-Remali, Takuya Shiota, Abdel Aouacheria, Sa Kan Yoo. https://www.embopress.org/doi/full/10.15252/embj.2021110454

Cardiomyocyte differentiation from human induced pluripotent stem cells is delayed following knockout of Bcl-2 – Tim Vervliet, Robin Duelen, Ankit Pradhan, Rita La Rovere, H. Llewelyn Roderick, Maurilio Sampaolesi. https://journals.biologists.com/jcs/article-abstract/136/2/jcs260216/286722

Transient targeting of BIM-dependent adaptive MCL1 preservation enhances tumor response to molecular therapeutics in non-small cell lung cancer – Kaixuan Shi, Haijiao Lu, Zhenfeng Zhang, Yujie Fu, Jie Wu, Shichao Zhou, Pengfei Ma, Kaiyan Ye, Shengzhe Zhang, Hailei Shi, Weiping Shi, Mei-Chun Cai, Xiaojing Zhao, Zhuang Yu, Jian Tang and Guanglei Zhuang. https://www.nature.com/articles/s41418-022-01064-2

Mechanisms of MCL-1 Protein Stability Induced by MCL-1 Antagonists in B-Cell Malignancies – Shady I. Tantawy, Aloke Sarkar, Stefan Hubner, Zhi Tan, William G. Wierda, Abdelraouf Eldeib, Shuxing Zhang, Steven Kornblau, Varsha Gandhi. https://aacrjournals.org/clincancerres/article-abstract/29/2/446/713974

Modulation of RNA splicing enhances response to BCL2 inhibition in leukemia – Eric Wang, Jose Mario Bello Pineda, Won Jun Kim, Sisi Chen, Jessie Bourcier, Maximilian Stahl, Simon J. Hogg, Jan Phillipp Bewersdorf, Cuijuan Han, Michael E. Singer, Daniel Cui, Caroline E. Erickson, Steven M. Tittley, Alexander V. Penson, Katherine Knorr, Robert F. Stanley, Jahan Rahman, Gnana Krishnamoorthy, James A. Fagin, Emily Creger, Elizabeth McMillan, Chi-Ching Mak, Matthew Jarvis, Carine Bossard, Darrin M. Beaupre, Robert K. Bradley, Omar Abdel-Wahab. https://www.cell.com/cancer-cell/fulltext/S1535-6108(22)00588-8

Death receptors

NF-κB/RelA controlled A20 limits TRAIL-induced apoptosis in pancreatic cancer – Claudia Geismann, Charlotte Hauser, Frauke Grohmann, Christian Schneeweis, Nico Bölter, Jan-Paul Gundlach, Günter Schneider, Christoph Röcken, Christian Meinhardt, Heiner Schäfer, Stefan Schreiber and Alexander Arlt. https://www.nature.com/articles/s41419-022-05535-9

Necroptosis and RIPK

RIPK1 blocks T cell senescence mediated by RIPK3 and caspase-8 – Takayuki Imanishi, Midori Unno, Natsumi Yoneda, Yasutaka Motomura, Miho Mochizuki, Takaharu Sasaki, Manolis Pasparakis, Takashi Saito. https://www.science.org/doi/full/10.1126/sciadv.add6097

OASL phase condensation induces amyloid-like fibrillation of RIPK3 to promote virus-induced necroptosis – Shin-Ae Lee, Lin-Chun Chang, WooRam Jung, James W. Bowman, Dokyun Kim, Weiqiang Chen, Suan-Sin Foo, Youn Jung Choi, Un Yung Choi, Anna Bowling, Ji-Seung Yoo and Jae U. Jung. https://www.nature.com/articles/s41556-022-01039-y

Myeloid-derived MIF drives RIPK1-mediated cerebromicrovascular endothelial cell death to exacerbate ischemic brain injury – Yan Li, Chengyu Zou, Chen Chen, Sixuan Li, Ziyu Zhu, Qiuyue Fan, Rui Pang, Fengshi Li, Zengai Chen, Zhenghong Wang, Weifeng Yu, Junying Yuan and Peiying Li. https://www.pnas.org/doi/10.1073/pnas.2219091120

TRAF6 regulates the abundance of RIPK1 and inhibits the RIPK1/RIPK3/MLKL necroptosis signaling pathway and affects the progression of colorectal cancer – Penghang Lin, Chunlin Lin, Ruofan He, Hui Chen, Zuhong Teng, Hengxin Yao, Songyi Liu, Robert M. Hoffman, Jianxin Ye and Guangwei Zhu. https://www.nature.com/articles/s41419-022-05524-y

Pyroptosis

Gasdermin D pore-forming activity is redox-sensitive – Pascal Devant, Elvira Boršić, Elsy M. Ngwa, Haopeng Xiao, Edward T. Chouchani, Jay R. Thiagarajah, Iva Hafner-Bratkovič, Charles L. Evavold, Jonathan C. Kagan. https://www.cell.com/cell-reports/fulltext/S2211-1247(23)00019-0

NET formation is independent of gasdermin D and pyroptotic cell death – Darko Stojkov, Meike J. Claus, Evelyne Kozlowski, Kevin Oberson, Olivier P. Schären, Charaf Benarafa, Shida Yousefi, Hans-Uwe Simon. https://www.science.org/doi/abs/10.1126/scisignal.abm0517

Protein engineering reveals that gasdermin A preferentially targets mitochondrial membranes over the plasma membrane during pyroptosis – Hannah C. Kondolf, Dana A. D’Orlando, George R. Dubyak, Derek W. Abbott. https://www.jbc.org/article/S0021-9258(23)00040-6/fulltext

Reviews

Endogenous and imposed determinants of apoptotic vulnerabilities in cancer – Kristopher A. Sarosiek, Kris C. Wood. https://www.cell.com/trends/cancer/fulltext/S2405-8033(22)00224-2

Apoptotic mitochondrial poration by a growing list of pore-forming BCL-2 family proteins – Tudor Moldoveanu. https://onlinelibrary.wiley.com/doi/abs/10.1002/bies.202200221

The web of death: the expanding complexity of necroptotic signaling – Christopher R. Horne, André L. Samson, James M. Murphy. https://www.cell.com/trends/cell-biology/fulltext/S0962-8924(22)00139-8

Arming a killer: mitochondrial regulation of CD8+ T cell cytotoxicity – Miriam Lisci, Gillian M. Griffiths. https://www.cell.com/trends/cell-biology/fulltext/S0962-8924(22)00138-6

Comments

Poking holes in pyroptosis paradigms – Leslie K. Ferrarelli. https://www.science.org/doi/full/10.1126/scisignal.adg7522

Monocytes: A Promising New TRAIL in Ovarian Cancer Cell Therapy – Stephanie Chow; Oliver Dorigo. https://aacrjournals.org/clincancerres/article-abstract/29/2/299/713966

Profile of Vishva M. Dixit – Jennifer Viegas. https://www.pnas.org/doi/10.1073/pnas.2219482119

January 5, 2023 cris

ApoList – December 2022

Bcl-2 family proteins

BCL-xL inhibition potentiates cancer therapies by redirecting the outcome of p53 activation from senescence to apoptosis – Vijaya Bharti, Reese Watkins, Amrendra Kumar, Rebecca L. Shattuck-Brandt, Alexis Mossing, Arjun Mittra, Chengli Shen, Allan Tsung, Alexander E. Davies, Walter Hanel, John C. Reneau, Catherine Chung, Gina M. Sizemore, Ann Richmond, Vivian L. Weiss, Anna E. Vilgelm. https://www.cell.com/cell-reports/fulltext/S2211-1247(22)01718-1

SRSF6 balances mitochondrial-driven innate immune outcomes through alternative splicing of BAX – Allison R Wagner, Chi G Weindel, Kelsi O West, Haley M Scott, Robert O Watson, Kristin L Patrick. https://elifesciences.org/articles/82244

Endoplasmic reticulum protein BIK binds to and inhibits mitochondria-localized anti-apoptotic proteins – Elizabeth J. Osterlund, Nehad Hirmiz, Dang Nguyen, James M. Pemberton, Qiyin Fang, David W. Andrews. https://www.jbc.org/article/S0021-9258(22)01306-0/fulltext

Lisaftoclax (APG-2575) Is a Novel BCL-2 Inhibitor with Robust Antitumor Activity in Preclinical Models of Hematologic Malignancy – Jing Deng, Aneel Paulus, Douglas D. Fang, Alak Manna, Guangfeng Wang, Hengbang Wang, Saijie Zhu, Jianyong Chen, Ping Min, Yan Yin, Navnita Dutta, Nabanita Halder, Gina Ciccio, [..] Asher Chanan-Khan, Yifan Zhai. https://aacrjournals.org/clincancerres/article-abstract/28/24/5455/711449

Targeting anti-apoptotic pathways eliminates senescent melanocytes and leads to nevi regression – Jaskaren Kohli, Chen Ge, Eleni Fitsiou, Miriam Doepner, Simone M. Brandenburg, William J. Faller, Todd W. Ridky and Marco Demaria. https://www.nature.com/articles/s41467-022-35657-9

Death receptors

TRAIL receptors promote constitutive and inducible IL-8 secretion in non-small cell lung carcinoma – Francesca Favaro, Fedra Luciano-Mateo, Joaquim Moreno-Caceres, Miguel Hernández-Madrigal, Demi Both, Chiara Montironi, Franziska Püschel, Ernest Nadal, Eric Eldering and Cristina Muñoz-Pinedo. https://www.nature.com/articles/s41419-022-05495-0

ATG9A prevents TNF cytotoxicity by an unconventional lysosomal targeting pathway – Jon Huyghe, Dario Priem, Lisette Van Hove, Barbara Gilbert, Jürgen Fritsch, Yasuo Uchiyama, Esther Hoste, Geert van Loo, Mathieu J. M. Bertrand. https://www.science.org/doi/abs/10.1126/science.add6967

Neutrophils and macrophages drive TNF-induced lethality via TRIF/CD14-mediated responses – Hayley I. Muendlein, Wilson M. Connolly, James Cameron, David Jetton, Zoie Magri, Irina Smirnova, Edouard Vannier, Xudong Li, Amanda J. Martinot, Rebecca Batorsky, Alexander Poltorak. https://www.science.org/doi/abs/10.1126/sciimmunol.add0665

Caspases

Blocking Caspase-1/Gsdmd and Caspase-3/-8/Gsdme pyroptotic pathways rescues silicosis in mice – Lulu Kang, Jinghong Dai, Yufang Wang, Peiliang Shi, Yujie Zou, Jingwen Pei, Yaqiong Tian, Ji Zhang, Visarut Codey Buranasudja, Jingyu Chen, Hourong Cai, Xiang Gao, Zhaoyu Lin. https://journals.plos.org/plosgenetics/article?id=10.137

Pyroptosis

Gasdermins and pannexin-1 mediate pathways of chemotherapy-induced cell lysis in hematopoietic malignancies – Bowen Zhou, Christopher B. Ryder, George R. Dubyak, Derek W. Abbott. https://www.science.org/doi/abs/10.1126/scisignal.abl6781

Spatiotemporal control of necroptotic cell death and plasma membrane recruitment using engineered MLKL domains – Amir Taslimi, Kaiah M. Fields, Kristin D. Dahl, Qi Liu and Chandra L. Tucker. https://www.nature.com/articles/s41420-022-01258-0

Miscellanous

Inhibition of Glucose Uptake Blocks Proliferation but Not Cytotoxic Activity of NK Cells – Lea Katharina Picard, Elisabeth Littwitz-Salomon, Herbert Waldmann, Carsten Watzl. https://www.mdpi.com/2073-4409/11/21/3489

Myeloid cell-derived proteases produce a proinflammatory form of IL-37 that signals via IL-36 receptor engagement – Graeme P. Sullivan, Pavel Davidovich, Natalia Muñoz-Wolf, Ross W. Ward, Yasmina E. Hernandez Santana,5, Danielle M. Clancy, Aoife Gorman, Zaneta Najda, Boris Turk6, Patrick T. Walsh, Ed C. Lavelle, Seamus J. Martin. https://www.science.org/doi/abs/10.1126/sciimmunol.ade5728

Mitochondrial genome recovery by ATFS-1 is essential for development after starvation – Nandhitha Uma Naresh, Sookyung Kim, Tomer Shpilka, Qiyuan Yang, Yunguang Du, Cole M. Haynes. https://www.cell.com/cell-reports/fulltext/S2211-1247(22)01771-5

[maybe also post-MOMP?!]

Reviews / Comments

Pore-forming proteins as drivers of membrane permeabilization in cell death pathways – Peter Vandenabeele, Geert Bultynck and Savvas N. Savvides. https://www.nature.com/articles/s41580-022-00564-w

The path to venetoclax resistance is paved with mutations, metabolism, and more – Graeme P. Sullivan, Lyndsey Flanagan, Daniel Alencar Rodrigues, Tríona Ní Chonghaile. https://www.science.org/doi/abs/10.1126/scitranslmed.abo6891

mTORC1 beyond anabolic metabolism: Regulation of cell death – Jiajun Zhu, Hua Wang, Xuejun Jiang. https://rupress.org/jcb/article/221/12/e202208103/213609

Surviving death: emerging concepts of RIPK3 and MLKL ubiquitination in the regulation of necroptosis – Rebekka Karlowitz, Sjoerd J. L. van Wijk. https://febs.onlinelibrary.wiley.com/doi/full/10.1111/febs.16255

December 2, 2022 cris

ApoList – November 2022

Bcl-2 family proteins

Heightened apoptotic priming of vascular cells across tissues and life span predisposes them to cancer therapy-induced toxicities – Johan K. E. Spetz, Mary H. C. Florido, Cameron S. Fraser, Xingping Qin, Jonathan Choiniere, Stacey J. Yu, Rumani Singh, Max Friesen, Lee L. Rubin, Joe-Elie Salem, Javid J. Moslehi, Kristopher A. Sarosiek. https://www.science.org/doi/full/10.1126/sciadv.abn6579

A Mesenchymal Tumor Cell State Confers Increased Dependency on the BCL-XL Antiapoptotic Protein in Kidney Cancer – Treg Grubb, Smruthi Maganti, John Michael Krill-Burge, Cameron Fraser, Laura Stransky, Tomas Radivoyevitch, Kristopher A. Sarosiek, Francisca Vazquez, William G. Kaelin, Jr, Abhishek A. Chakraborty. https://aacrjournals.org/clincancerres/article-abstract/28/21/4689/709828

Modulation of Ca2+ signaling by antiapoptotic Bcl-2 versus Bcl-xL: From molecular mechanisms to relevance for cancer cell survival – Nicolas Rosa, Femke Speelman-Rooms, Jan B. Parys, Geert Bultynck. https://www.sciencedirect.com/science/article/abs/pii/S0304419X22001160

Reciprocal effects of mTOR inhibitors on pro-survival proteins dictate therapeutic responses in tuberous sclerosis complex – McNamara MC, Hosios AM, Torrence ME, Zhao T, Fraser C, Wilkinson M, Kwiatkowski DJ, Henske EP, Wu CL, Sarosiek KA, Valvezan AJ, Manning BD.. https://www.cell.com/iscience/fulltext/S2589-0042(22)01730-8

Microfluidic-based dynamic BH3 profiling predicts anticancer treatment efficacy – Albert Manzano-Muñoz, José Yeste, María A. Ortega, Fernando Martín, Anna López, Jordi Rosell, Sandra Castro, César Serrano, Josep Samitier, Javier Ramón-Azcón and Joan Montero. https://www.nature.com/articles/s41698-022-00333-0

Death receptors and RIPK

cFLIP suppression and DR5 activation sensitize senescent cancer cells to senolysis – Liqin Wang, Haojie Jin, Fleur Jochems, Siying Wang, Cor Lieftink, Isabel Mora Martinez, Giulia De Conti, Finn Edwards, Rodrigo Leite de Oliveira, Arnout Schepers, Yangyang Zhou, Jiaojiao Zheng, Wei Wu, Xingling Zheng, Shengxian Yuan, Jing Ling, Kathy Jastrzebski, Matheus Dos Santos Dias, Ji-Ying Song, Patrick N. H. Celie, Hideo Yagita, Ming Yao, Weiping Zhou, Roderick L. Beijersbergen, Wenxin Qin and René Bernards. https://www.nature.com/articles/s43018-022-00462-2

An orally active, small-molecule TNF inhibitor that disrupts the homotrimerization interface improves inflammatory arthritis in mice – Nasir Javaid, Mahesh Chandra Patra, Da-Eun Cho, Maria Batool, Yoongeun Kim, Gwang Muk Choi, Moon Suk Kim, Dae-Hyun Hahm, Sangdun Choi. https://www.science.org/doi/abs/10.1126/scisignal.abi8713

SENP1 prevents steatohepatitis by suppressing RIPK1-driven apoptosis and inflammation – Lingjie Yan, Tao Zhang, Kai Wang, Zezhao Chen, Yuanxin Yang, Bing Shan, Qi Sun, Mengmeng Zhang, Yichi Zhang, Yedan Zhong, Nan Liu, Jinyang Gu and Daichao Xu. https://www.nature.com/articles/s41467-022-34993-0

Generative deep learning enables the discovery of a potent and selective RIPK1 inhibitor – Yueshan Li, Liting Zhang, Yifei Wang, Jun Zou, Ruicheng Yang, Xinling Luo, Chengyong Wu, Wei Yang, Chenyu Tian, Haixing Xu, Falu Wang, Xin Yang, Linli Li and Shengyong Yang. https://www.nature.com/articles/s41467-022-34692-w

Tyrosine phosphorylation regulates RIPK1 activity to limit cell death and inflammation – Hailin Tu, Weihang Xiong, Jie Zhang, Xueqiang Zhao and Xin Lin. https://www.nature.com/articles/s41467-022-34080-4

Caspases / Apaf-1

Caspase-8 inactivation drives autophagy-dependent inflammasome activation in myeloid cells – Yung-Hsuan Wu, Shu-Ting Mo, I-Ting Chen, Fu-Yi Hsieh, Shie-Liang Hsieh, Jinake Zhang, Ming-Zong Lai. https://www.science.org/doi/full/10.1126/sciadv.abn9912

Targeting the MITF/APAF-1 axis as salvage therapy for MAPK inhibitors in resistant melanoma – Pietro Carotenuto, Alessia Romano. . Anna Barbato. Paola Quadrano. Simona Brillante. Mariagrazia Volpe. Luigi Ferrante, Roberta Tammaro, Manuela Morleo, Rossella De Cegli, Antonella Iuliano, Marialuisa Testa, Fabrizio Andreone, Gennaro Ciliberto, Eduardo Clery, Giancarlo Troncone. Giuseppe Palma, Claudio Arra. Antonio Barbieri, Mariaelena Capone. Gabriele Madonna, Paolo A. Ascierto. Luisa Lanfrancone, Alessia Indrieri, Brunella Franco. https://www.cell.com/cell-reports/fulltext/S2211-1247(22)01466-8

Genuine selective caspase-2 inhibition with new irreversible small peptidomimetics – Elodie Bosc, Julie Anastasie, Feryel Soualmia, Pascale Coric, Ju Youn Kim, Lily Q. Wang, Gullen Lacin, Kaitao Zhao, Ronak Patel, Eric Duplus, Philippe Tixador, Andrew A. Sproul, Bernard Brugg, Michelle Reboud-Ravaux, Carol M. Troy, Michael L. Shelanski, Serge Bouaziz, Michael Karin, Chahrazade El Amri and Etienne D. Jacotot. https://www.nature.com/articles/s41419-022-05396-2

Neurovascular injury associated non-apoptotic endothelial caspase-9 and astroglial caspase-9 mediate inflammation and contrast sensitivity decline – Crystal Colón Ortiz, Albertine M. Neal, Maria I. Avrutsky, Monica Choi, Jade Smart, Jacqueline Lawson & Carol M. Troy. https://www.nature.com/articles/s41419-022-05387-3

Pyroptosis

Sublytic gasdermin-D pores captured in atomistic molecular simulations – Stefan L Schaefer, Gerhard Hummer. https://elifesciences.org/articles/81432

Nuclear translocation of Gasdermin D sensitizes colorectal cancer to chemotherapy in a pyroptosis-independent manner – Xiao Peng, Risi Na, Wenting Zhou, Xiaole Meng, Yunhai Yang, Shohreh Amini and Liwei Song. https://www.nature.com/articles/s41388-022-02503-7

Ferroptosis

Ferroptosis of tumour neutrophils causes immune suppression in cancer – Rina Kim, Ayumi Hashimoto, Nune Markosyan, Vladimir A. Tyurin, Yulia Y. Tyurina, Gozde Kar, Shuyu Fu, Mohit Sehgal, Laura Garcia-Gerique, Andrew Kossenkov, Bereket A. Gebregziabher, John W. Tobias, Kristin Hicks, Rebecca A. Halpin, Nevena Cvetesic, Hui Deng, Laxminarasimha Donthireddy, Andrew Greenberg, Brian Nam, Robert H. Vonderheide, Yulia Nefedova, Valerian E. Kagan and Dmitry I. Gabrilovich. https://www.nature.com/articles/s41586-022-05443-0

Doxorubicin causes ferroptosis and cardiotoxicity by intercalating into mitochondrial DNA and disrupting Alas1-dependent heme synthesis – Ko Abe, Masataka Ikeda, Tomomi Ide, Tomonori Tadokoro, Hiroko Deguchi Miyamoto, Shun Furusawa, Yoshitomo Tsutsui, Ryo Miyake, Kosei Ishimaru, Masatsugu Watanabe, Shouji Matsushima, Tomoko Koumura, Ken-ichi Yamada, Hirotaka Imai, Hiroyuki Tsutsui. https://www.science.org/doi/abs/10.1126/scisignal.abn8017

Miscellanous

Colon tumour cell death causes mTOR dependence by paracrine P2X4 stimulation – Mark Schmitt, Fatih Ceteci, Jalaj Gupta, Marina Pesic, Tim W. Böttger, Adele M. Nicolas, Kilian B. Kennel, Esther Engel, Matthias Schewe, Asude Callak Kirisözü, Valentina Petrocelli, Yasamin Dabiri, Julia Varga, Mallika Ramakrishnan, Madina Karimova, Andrea Ablasser, Toshiro Sato, Melek C. Arkan, Frederic J. de Sauvage and Florian R. Greten. https://www.nature.com/articles/s41586-022-05426-1

Reviews

Mitochondria and cell death-associated inflammation – Esmee Vringer and Stephen W. G. Tait. https://www.nature.com/articles/s41418-022-01094-w

T cell-mediated additive cytotoxicity – death by multiple bullets – Bettina Weigelin, Peter Friedl. https://www.cell.com/trends/cancer/fulltext/S2405-8033(22)00160-1

Extrinsic cell death pathway plasticity: a driver of clonal evolution in cancer? – Eric Seidel and Silvia von Karstedt. https://www.nature.com/articles/s41420-022-01251-7

Signaling pathways and defense mechanisms of ferroptosis – Jiao Liu, Rui Kang, Daolin Tang. https://febs.onlinelibrary.wiley.com/doi/full/10.1111/febs.16059

Balancing life and death: BCL‐2 family members at diverse ER–mitochondrial contact sites – Robert E. Means, Samuel G. Katz. https://febs.onlinelibrary.wiley.com/doi/full/10.1111/febs.16241

Comments

XL-ing at Induction of Apoptosis in Kidney Cancer through Inhibition of BCL-XL – Naitao Wang, A. Ari Hakimi, Yu Chen. https://aacrjournals.org/clincancerres/article-abstract/28/21/4600/709829

A cFLIP-flop switch for senolysis – Dorothy N. Y. Fan and Clemens A. Schmitt. https://www.nature.com/articles/s43018-022-00455-1

BH3-Mimetic Tolerance Is Driven by Sublethal Cytochrome c Release. https://aacrjournals.org/cancerdiscovery/article-abstract/12/11/OF7/709980

Glucose Metabolism in TAMs Promotes Metastasis and Drug Resistance. https://aacrjournals.org/cancerdiscovery/article-abstract/12/11/2495/710000

November 2, 2022 cris

ApoList – October 2022

Bcl-2 family proteins

Sublethal cytochrome c release generates drug-tolerant persister cells – Halime Kalkavan, Mark J. Chen, Jeremy C. Crawford, Giovanni Quarato, Patrick Fitzgerald, Stephen W.G. Tait, Colin R. Goding, Douglas R. Green. https://www.cell.com/cell/fulltext/S0092-8674(22)00978-3

Apoptotic priming is defined by the dynamic exchange of Bcl-2 proteins between mitochondria and cytosol – Louise E. King, Ricardo Rodriguez-Enriquez, Robert Pedley, Charlotte E. L. Mellor, Pengbo Wang, Egor Zindy, Michael R. H. White, Keith Brennan and Andrew P. Gilmore. https://www.nature.com/articles/s41418-022-01013-z

Alternative splicing of apoptosis genes promotes human T cell survival – Davia Blake, Caleb M Radens, Max B Ferretti, Matthew R Gazzara, Kristen W Lynch. https://elifesciences.org/articles/80953

BOK controls ER proteostasis and physiological ER stress responses in neurons – Franziska Walter, Beatrice D’Orsi, Anagha Jagannathan, Heiko Dussmann and Jochen H. M. Prehn. https://www.frontiersin.org/articles/10.3389/fcell.2022.915065/full

MCL-1 is a master regulator of cancer dependency on fatty acid oxidation – Michelle S. Prew, Utsarga Adhikary, Dong Wook Choi, Erika P. Portero, Joao A. Paulo, Pruthvi Gowda, Amit Budhraja, Joseph T. Opferman, Steven P. Gygi, Nika N. Danial, Loren D. Walensky. https://www.cell.com/cell-reports/fulltext/S2211-1247(22)01286-4

Decoding the concealed transcriptional signature of the apoptosis-related BCL2 antagonist/killer 1 (BAK1) gene in human malignancies – Konstantina Athanasopoulou, Panagiotis G. Adamopoulos, Glykeria N. Daneva and Andreas Scorilas. https://link.springer.com/article/10.1007/s10495-022-01753-w

c-Myc plays a critical role in the antileukemic activity of the Mcl-1-selective inhibitor AZD5991 in acute myeloid leukemia – Shuang Liu, Xinan Qiao, Shuangshuang Wu, Yuqinq Gai, Yongwei Su, Holly Edwards, Yue Wang, Hai Lin, Jeffrey W. Taub, Guan Wang, Yubin Ge. https://link.springer.com/article/10.1007/s10495-022-01756-7

A novel BH3 mimetic Bcl-2 inhibitor promotes autophagic cell death and reduces in vivo Glioblastoma tumor growth – Seyma Calis, Berna Dogan, Serdar Durdagi, Asuman Celebi, Ozlem Yapicier, Turker Kilic, Eda Tahir Turanli and Timucin Avsar, https://www.nature.com/articles/s41420-022-01225-9

Splicing factor BUD31 promotes ovarian cancer progression through sustaining the expression of anti-apoptotic BCL2L12 – Zixiang Wang, Shourong Wang, Junchao Qin, Xiyu Zhang, Gang Lu, Hongbin Liu, Haiyang Guo, Ligang Wu, Victoria O. Shender, Changshun Shao, Beihua Kong and Zhaojian Liu. https://www.nature.com/articles/s41467-022-34042-w

Death receptors

Limiting glutamine utilization activates a GCN2/TRAIL-R2/Caspase-8 apoptotic pathway in glutamine-addicted tumor cells – Rosario Yerbes, Rocío Mora-Molina, F. Javier Fernández-Farrán, Laura Hiraldo, Abelardo López-Rivas and Carmen Palacios. https://www.nature.com/articles/s41419-022-05346-y

MMP7 cleavage of amino-terminal CD95 death receptor switches signaling toward non-apoptotic pathways – Shoji F. Kenji, Keerthi Kurma, Brigitte Collet, Christelle Oblet, Laure Debure, Carmelo Di Primo, Laëtitia Minder, Franck Vérité, Yannic Danger, Mickael Jean, Aubin Penna, Nicolas Levoin and Patrick Legembre. https://www.nature.com/articles/s41419-022-05352-0

Phase I trial of the TNF-α inhibitor certolizumab plus chemotherapy in stage IV lung adenocarcinomas – Paul K. Paik, Jia Luo, Ni Ai, Rachel Kim, Linda Ahn, Anup Biswas, Courtney Coker, Wanchao Ma, Phillip Wong, Darren J. Buonocore, W. Victoria Lai, Jamie E. Chaft, Swarnali Acharyya, Joan Massagué and Mark G. Kris. https://www.nature.com/articles/s41467-022-33719-6

Escaping cell death via TRAIL decoy receptors: a systematic review of their roles and expressions in colorectal cancer – Kelly Xue Jing Jong, Elsa Haniffah Mejia Mohamed and Zaridatul Aini Ibrahim. https://link.springer.com/article/10.1007/s10495-022-01774-5

Caspases

PIDDosome-SCAP crosstalk controls high-fructose-diet-dependent transition from simple steatosis to steatohepatitis – Ju Youn Kim, Lily Q. Wang, Valentina C. Sladky, Tae Gyu Oh, Junlai Liu, Kaitlyn Trinh, Felix Eichin, Michael Downes, Mojgan Hosseini, Etienne D. Jacotot, Ronald M. Evans, Andreas Villunger, Michael Karin. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(22)00348-5

Molecular mechanism of RIPK1 and caspase-8 in homeostatic type I interferon production and regulation – Yaqiu Wang, Rajendra Karki, Raghvendra Mall, Bhesh Raj Sharma, Ravi C. Kalathur, SangJoon Lee, Balabhaskararao Kancharana, Matthew So, Katie L. Combs, Thirumala-Devi Kanneganti. https://www.cell.com/cell-reports/fulltext/S2211-1247(22)01275-X

Necroptosis

Caspase-8 and FADD prevent spontaneous ZBP1 expression and necroptosis – Diego A. Rodriguez, Giovanni Quarato, Swantje Liedmann, Bart Tummers, Ting Zhang, Cliff Guy, Jeremy Chase Crawford, Gustavo Palacios, Stephane Pelletier, Halime Kalkavan, Jeremy J. P. Shaw, Patrick Fitzgerald, Mark J. Chen, Siddharth Balachandran and Douglas R. Green. https://www.pnas.org/doi/10.1073/pnas.2207240119

Human ZBP1 induces cell death-independent inflammatory signaling via RIPK3 and RIPK1 – Ruoshi Peng, Chris Kedong Wang, Xuan Wang-Kan, Manja Idorn, Majken Kjær, Felix Y Zhou, Berthe Katrine Fiil, Frederik Timmermann, Susana L Orozco, Julia McCarthy, Carol S Leung, Xin Lu, Katrin Bagola, Jan Rehwinkel, Andrew Oberst, Jonathan Maelfait, Søren R Paludan, Mads Gyrd-Hansen. https://www.embopress.org/doi/full/10.15252/embr.202255839

Pyroptosis

GSDMD drives canonical inflammasome‐induced neutrophil pyroptosis and is dispensable for NETosis – Dhruv Chauhan, Dieter Demon, Lieselotte Vande Walle, Oonagh Paerewijck, Annalisa Zecchin, Leslie Bosseler, Karin Santoni, Rémi Planès, Silvia Ribo, Amelie Fossoul, Amanda Gonçalves, Hanne Van Gorp, Nina Van Opdenbosch, Filip Van Hauwermeiren, Etienne Meunier, Andy Wullaert, Mohamed Lamkanfi. https://www.embopress.org/doi/abs/10.15252/embr.202154277

Gasdermin D restricts anti-tumor immunity during PD-L1 checkpoint blockade – Yuying Jiang, Yongbing Yang, Yingchao Hu, Rui Yang, Jiajia Huang, Yi Liu, Yuqing Wu, Sheng Li, Chunmei Ma, Fiachra Humphries, Bingwei Wang, Xi Wang, Zhibin Hu, Shuo Yang. https://www.cell.com/cell-reports/fulltext/S2211-1247(22)01409-7

GSDME deficiency leads to the aggravation of UVB-induced skin inflammation through enhancing recruitment and activation of neutrophils – Yujie Chen, Ni Lian, Sihan Chen, Ta Xiao, Yangying Ke, Yiqun Zhang, Changjun Song, Yong Yang, Song Xu, Heng Gu and Xu Chen. https://www.nature.com/articles/s41419-022-05276-9

Enhancing Gasdermin-induced tumor pyroptosis through preventing ESCRT-dependent cell membrane repair augments antitumor immune response – Zhaoting Li, Fanyi Mo, Yixin Wang, Wen Li, Yu Chen, Jun Liu, Ting-Jing Chen-Mayfield and Quanyin Hu. https://www.nature.com/articles/s41467-022-34036-8

Ferroptosis

Selective ferroptosis vulnerability due to familial Alzheimer’s disease presenilin mutations – Mark A. Greenough, Darius J. R. Lane, Rachelle Balez, Helena Targa Dias Anastacio, Zhiwen Zeng, Katherine Ganio, Christopher A. McDevitt, Karla Acevedo, Abdel Ali Belaidi, Jari Koistinaho, Lezanne Ooi, Scott Ayton and Ashley I. Bush. https://www.nature.com/articles/s41418-022-01003-1

Efferocytosis, entosis, phagoptosis etc

Mobilizing phospholipids on tumor plasma membrane implicates phosphatidylserine externalization blockade for cancer immunotherapy – Weihong Wang, Shaoxian Wu, Zhanpeng Cen, Yixin Zhang, Yuang Chen, Yixian Huang, Anthony R. Cillo, Joshua S. Prokopec, Giovanni Quarato, Dario A.A. Vignali, Jacob Stewart-Ornstein, Song Li, Binfeng Lu, Yi-Nan Gong. https://www.cell.com/cell-reports/fulltext/S2211-1247(22)01447-4

Non-autonomous cell death induced by the Draper phagocytosis receptor requires signaling through the JNK and SRC pathways – Sandy B. Serizier; Jeanne S. Peterson; Kimberly McCall. https://journals.biologists.com/jcs/article-abstract/135/20/jcs250134/278232

Reviews

Understanding MCL1: from cellular function and regulation to pharmacological inhibition – Mónica Sancho, Diego Leiva, Estefanía Lucendo, Mar Orzáez. https://febs.onlinelibrary.wiley.com/doi/full/10.1111/febs.16136

Dying in self-defence: a comparative overview of immunogenic cell death signalling in animals and plants – Takaki Maekawa, Hamid Kashkar and Núria S. Coll. https://www.nature.com/articles/s41418-022-01060-6

Stressed to death: Mitochondrial stress responses connect respiration and apoptosis in cancer – Jacob M. Winter, Tarun Yadav, Jared Rutter. https://www.cell.com/molecular-cell/fulltext/S1097-2765(22)00708-0

What role does pyroptosis play in cancer? – Chen Huang, Jian Li, Chenliang Zhang. https://www.sciencedirect.com/science/article/pii/S2212877822001569

Comments

Cap CASP, not SCAP, to fight steatohepatitis – Wolfram Goessling. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(22)00404-1

Vitamin K: A new guardian against ferroptosis – Tal Hirschhorn, Brent R. Stockwell. https://www.cell.com/molecular-cell/fulltext/S1097-2765(22)00958-3

Persisting through apoptosis – Michael Attwaters. https://www.nature.com/articles/s41580-022-00544-0

October 3, 2022 cris

ApoList – September 2022

Bcl-2 family proteins

Small molecule SJ572946 activates BAK to initiate apoptosis – Giridhar Sekar, Geetika Singh, Xingping Qin, Cristina D. Guibao, Brittany Schwam, Zintis Inde, Christy R. Grace, Weixing Zhang, P. Jake Slavish, Wenwei Lin, Taosheng Chen, Richard E. Lee, Zoran Rankovic, Kristopher Sarosiek, Tudor Moldoveanu. https://www.cell.com/iscience/fulltext/S2589-0042(22)01336-0

Structure of the BAK-activating antibody 7D10 bound to BAK reveals an unexpected role for the α1-α2 loop in BAK activation – Adeline Y. Robin, Michelle S. Miller, Sweta Iyer, Melissa X. Shi, Ahmad Z. Wardak, Daisy Lio, Nicholas A. Smith, Brian J. Smith, Richard W. Birkinshaw, Peter E. Czabotar, Ruth M. Kluck and Peter M. Colman. https://www.nature.com/articles/s41418-022-00961-w

BET inhibition induces vulnerability to MCL1 targeting through upregulation of fatty acid synthesis pathway in breast cancer – Gonghong Yan, Augustin Luna, Heping Wang, Behnaz Bozorgui, Xubin Li, Maga Sanchez, Zeynep Dereli, Nermin Kahraman, Goknur Kara, Xiaohua Chen, Caishang Zheng, Daniel McGrail, Nidhi Sahni, Yiling Lu, Ozgun Babur, Murat Cokol, Bora Lim, Bulent Ozpolat, Chris Sander, Gordon B. Mills, Anil Korkut. https://www.cell.com/cell-reports/fulltext/S2211-1247(22)01128-7

Chlamydia trachomatis inhibits apoptosis in infected cells by targeting the pro-apoptotic proteins Bax and Bak – Collins Waguia Kontchou, Ian E. Gentle, Arnim Weber, Axel Schoeniger, Frank Edlich and Georg Häcker. https://www.nature.com/articles/s41418-022-00995-0

Exploiting endogenous and therapy-induced apoptotic vulnerabilities in immunoglobulin light chain amyloidosis with BH3 mimetics – Cameron S. Fraser, Johan K. E. Spetz, Xingping Qin, Adam Presser, Jonathan Choiniere, Chendi Li, Stacey Yu, Frances Blevins, Aaron N. Hata, Jeffrey W. Miller, Gary A. Bradshaw, Marian Kalocsay, Vaishali Sanchorawala, Shayna Sarosiek and Kristopher A. Sarosiek. https://www.nature.com/articles/s41467-022-33461-z

Death receptors

PP6 negatively modulates LUBAC-mediated M1-ubiquitination of RIPK1 and c-FLIPL to promote TNFα-mediated cell death – Guowei Wu, Dekang Li, Wei Liang, Weimin Sun, Xingxing Xie, Yilun Tong, Bing Shan, Mengmeng Zhang, Xiaojuan Lu, Junying Yuan and Ying Li. https://www.nature.com/articles/s41419-022-05206-9

Caspases

Caspase-3–Induced Activation of SREBP2 Drives Drug Resistance via Promotion of Cholesterol Biosynthesis in Hepatocellular Carcinoma – Etienne Ho Kit Mok, Carmen Oi Ning Leung, Lei Zhou, Martina Mang Leng Lei, Hoi Wing Leung, Man Tong, Tin Lok Wong, Eunice Yuen Ting Lau, Irene Oi Lin Ng, Jin Ding, Jing Ping Yun, Jun Yu, Hui Lian Zhu, Chi Ho Lin, Dan Lindholm, Kit Sum Leung, Jonathan D. Cybulski, David M. Baker, Stephanie M, Terence Kin Wah Lee. https://aacrjournals.org/cancerres/article-abstract/82/17/3102/708279

Coronaviruses exploit a host cysteine-aspartic protease for replication – Hin Chu, Yuxin Hou, Dong Yang, Lei Wen, Huiping Shuai, Chaemin Yoon, Jialu Shi, Yue Chai, Terrence Tsz-Tai Yuen, Bingjie Hu, Cun Li, Xiaoyu Zhao, Yixin Wang, Xiner Huang, Kin Shing Lee, Cuiting Luo, Jian-Piao Cai, Vincent Kwok-Man Poon, Chris Chung-Sing Chan, Anna Jinxia Zhang, Shuofeng Yuan, Ko-Yung Sit, Dominic Chi-Chung Foo, Wing-Kuk Au, Kwok-Yung Yuen. https://www.nature.com/articles/s41586-022-05148-4

Necroptosis

Membrane permeabilization is mediated by distinct epitopes in mouse and human orthologs of the necroptosis effector, MLKL – Ashish Sethi, Christopher R. Horne, Cheree Fitzgibbon, Karyn Wilde, Katherine A. Davies, Sarah E. Garnish, Annette V. Jacobsen, André L. Samson, Joanne M. Hildebrand, Ahmad Wardak, Peter E. Czabotar, Emma J. Petrie, Paul R. Gooley and James M. Murphy. https://www.nature.com/articles/s41418-022-00965-6

https://journals.biologists.com/jcs/article-abstract/135/17/jcs260091/276621

Pyroptosis

Gasdermin D-deficient mice are hypersensitive to acute kidney injury – Wulf Tonnus, Francesca Maremonti, Alexia Belavgeni, Markus Latk, Yoshihiro Kusunoki, Anne Brucker, Anne von Mässenhausen, Claudia Meyer, Sophie Locke, Florian Gembardt, Kristina Beer, Paul Hoppenz, Jan U. Becker, Christian Hugo, Hans-Joachim Anders, Stefan R. Bornstein, Feng Shao and Andreas Linkermann. https://www.nature.com/articles/s41419-022-05230-9

Ferroptosis

The MARCHF6 E3 ubiquitin ligase acts as an NADPH sensor for the regulation of ferroptosis – Kha The Nguyen, Sang-Hyeon Mun, Jihye Yang, Jongeun Lee, Ok-Hee Seok, Eunjeong Kim, Dasom Kim, So Young An, Dong-Young Seo, Jeong-Yong Suh, Yoontae Lee and Cheol-Sang Hwang. https://www.nature.com/articles/s41556-022-00973-1

Miscellanous

Induction of tumor cell autosis by myxoma virus-infected CAR-T and TCR-T cells to overcome primary and acquired resistance – Ningbo Zheng, Jing Fang, Gang Xue, Ziyu Wang, Xiaoyin Li, Mengshi Zhou, Guangxu Jin, Masmudur M. Rahman, Grant McFadden, Yong Lu. https://www.cell.com/cancer-cell/fulltext/S1535-6108(22)00357-9

NRF2 mediates melanoma addiction to GCDH by modulating apoptotic signalling – Sachin Verma, David Crawford, Ali Khateb, Yongmei Feng, Eduard Sergienko, Gaurav Pathria, Chen-Ting Ma, Steven H. Olson, David Scott, Rabi Murad, Eytan Ruppin, Michael Jackson and Ze’ev A. Ronai. https://www.nature.com/articles/s41556-022-00985-x

Reviews

Necroptosis at a glance – Kidong Kang, Christa Park, Francis Ka-Ming Chan. https://journals.biologists.com/jcs/article-abstract/135/17/jcs260091/276621

MLKL post-translational modifications: road signs to infection, inflammation and unknown destinations – Gianmaria Liccardi and Alessandro Annibaldi. https://www.nature.com/articles/s41418-022-01061-5

Monitoring yeast regulated cell death: trespassing the point of no return to loss of plasma membrane integrity – António Rego, António Ribeiro, Manuela Côrte-Real, Susana Rodrigues Chaves. https://link.springer.com/article/10.1007/s10495-022-01748-7

Comments

A conversation with Vishva Dixit – Ushma S. Neill. https://www.jci.org/articles/view/164341

Navigating ferroptosis via an NADPH sensor – Chao Mao and Boyi Gan. https://www.nature.com/articles/s41556-022-00963-3

The power of an idea: Andrew Wyllie – Richard A. Lockshin and Margaret C. Cummings

https://www.nature.com/articles/s41418-022-01043-7

Pro-ferroptotic fatty acid metabolism renders cancer cells immunogenic – Oliver Kepp, Guido Kroemer. https://www.cell.com/trends/cancer/fulltext/S2405-8033(22)00089-9

September 1, 2022 cris

ApoList – July/August 2022

Bcl-2 family proteins

The BCL‐2 family member BID plays a role during embryonic development in addition to its BH3‐only protein function by acting in parallel to BAX, BAK and BOK – Francine S Ke, Steven Holloway, Rachel T Uren, Agnes W Wong, Melissa H Little, Ruth M Kluck, Anne K Voss, Andreas Strasser. https://www.embopress.org/doi/abs/10.15252/embj.2021110300

Ca2+-mediated mitochondrial inner membrane permeabilization induces cell death independently of Bax and Bak – Giovanni Quarato, Fabien Llambi, Cliff S. Guy, Jaeki Min, Marisa Actis, Huan Sun, Shilpa Narina, Shondra M. Pruett-Miller, Junmin Peng, Zoran Rankovic and Douglas R. Green. https://www.nature.com/articles/s41418-022-01025-9

BH3 mimetic drugs cooperate with Temozolomide, JQ1 and inducers of ferroptosis in killing glioblastoma multiforme cells – Diane Moujalled, Adam G. Southon, Eiman Saleh, Kerstin Brinkmann, Francine Ke, Melinda Iliopoulos, Ryan S. Cross, Misty R. Jenkins, Duong Nhu, Zilu Wang, Melissa X. Shi, Ruth M. Kluck, Guillaume Lessene, Stephanie Grabow, Ashley I. Bush and Andreas Strasser. https://www.nature.com/articles/s41418-022-00977-2

BCL-2 isoform β promotes angiogenesis by TRiC-mediated upregulation of VEGF-A in lymphoma – Xiaohang Hang, Lei Zhao, Baohong Wu, Shujun Li, Pengpeng Liu, Jing Xu, Xinyuan Wang, Pengliang Chi, Chong Chen, Ting Niu, Lunzhi Dai and Yu Liu. https://www.nature.com/articles/s41388-022-02372-0

Ceramide-induced integrated stress response overcomes Bcl-2 inhibitor resistance in acute myeloid leukemia – Alexander C. Lewis, Victoria S. Pope, Melinda N. Tea, Manjun Li, Gus O. Nwosu, Thao M. Nguyen, Craig T. Wallington-Beddoe, Paul A. B. Moretti, Dovile Anderson, Darren J. Creek, Maurizio Costabile, Saira R. Ali, Chloe A. L. Thompson-Peach, B. Kate Dredge, Andrew G. Bert, Gregory J. Goodall, Paul G. Ekert, Anna L. Brown, Richard D’Andrea, Nirmal Robinson, Melissa R. Pitman, Daniel Thomas, David M. Ross, Briony L. Gliddon, Jason A. Powell, Stuart M. Pitson. https://ashpublications.org/blood/article/139/26/3737/485003

Structural and biochemical analyses of Bcl-xL in complex with the BH3 domain of peroxisomal testis-specific 1 – Lim D, Jin S, Shin HC, Kim W, Choi JS, Oh DB, Kim SJ, Seo J, Ku B. https://www.sciencedirect.com/science/article/pii/S0006291X22011147?via%3Dihub

A common deletion at BAK1 reduces enhancer activity and confers risk of intracranial germ cell tumors – Kyuto Sonehara, Yui Kimura, Yoshiko Nakano, Tatsuya Ozawa, Meiko Takahashi, Ken Suzuki, Takashi Fujii, Yuko Matsushita, Arata Tomiyama, Toshihiro Kishikawa, Kenichi Yamamoto, Tatsuhiko Naito, Tomonari Suzuki, Shigeru Yamaguchi, Tomoru Miwa, Hikaru Sasaki, Masashi Kitagawa, Naoyuki Ohe, Junya Fukai, Hideki Ogiwara, Atsufumi Kawamura, Satoru Miyawaki, Fumihiko Matsuda, Nobutaka Kiyokawa, Koichi Ichimura, Ryo Nishikawa, Yukinori Okada and Keita Terashima. https://www.nature.com/articles/s41467-022-32005-9

“Death” receptors

TRAIL protects the immature lung from hyperoxic injury – Tayyab Shahzad, Cho-Ming Chao, Stefan Hadzic, Judith Behnke, Luisa Biebach, Eva Böttcher-Friebertshäuser, Jochen Wilhelm, Anne Hilgendorff, Klaus-Peter Zimmer, Rory E. Morty, Saverio Bellusci and Harald Ehrhardt. https://www.nature.com/articles/s41419-022-05072-5

Engagement of TRAIL triggers degranulation and IFNγ production in human natural killer cells – Johannes Höfle, Timo Trenkner, Nadja Kleist, Vera Schwane, Sarah Vollmers, Bryan Barcelona, Annika Niehrs, Pia Fittje, Van Hung Huynh-Tran, Jürgen Sauter, Alexander H Schmidt, Sven Peine, Angelique Hoelzemer, Laura Richert, Marcus Altfeld, Christian Körner. https://www.embopress.org/doi/full/10.15252/embr.202154133

Indomethacin-induced oxidative stress enhances death receptor 5 signaling and sensitizes tumor cells to adoptive T-cell therapy – Nada S Aboelella, Caitlin Brandle, Ogacheko Okoko et al.. https://jitc.bmj.com/content/10/7/e004938

Engineered sTRAIL-armed MSCs overcome STING deficiency to enhance the therapeutic efficacy of radiotherapy for immune checkpoint blockade – Kevin Chih-Yang Huang, Shu-Fen Chiang, Hsin-Yu Chang, William Tzu-Liang Chen, Pei-Chen Yang, Tsung-Wei Chen, Ji-An Liang, An‑Cheng Shiau, Tao-Wei Ke and K. S. Clifford Chao. https://www.nature.com/articles/s41419-022-05069-0

Early B cell factor 4 modulates FAS-mediated apoptosis and promotes cytotoxic function in human immune cells – Satoshi Kubo, Rhea Kataria, Yikun Yao, Justin Q. Gabrielski, Lixin Zheng, Tovah E. Markowitz, Waipan Chan, Jian Song, Arun K. Boddapati, Keita Saeki, Björn Häupl, Ann Y. Park, Yan H. Cheng, Jing Cui, Thomas Oellerich and Michael J. Lenardo. https://www.pnas.org/doi/10.1073/pnas.2208522119

TAK1 Limits Death Receptor Fas-Induced Proinflammatory Cell Death in Macrophages – Kengo Maeda, Jun Nakayama, Shinsuke Taki and Hideki Sanjo. https://www.jimmunol.org/content/early/2022/08/10/jimmunol.2200322

Caspases

Apoptotic caspases suppress an MDA5-driven IFN response during productive replication of human papillomavirus type 31 – Ning Huang, Des’ree Groover, Blossom Damania and Cary Moody. https://www.pnas.org/doi/10.1073/pnas.2200206119

Apoptotic caspase inhibits innate immune signaling by cleaving NF-κBs in both Mammals and Flies – Di Wu, Zhaowei Wang, Jing Zhang, Adam G. Robinson, Bao Lyu, Ziyu Chen, Chong Wang, Bin Wei, Xiaojun Xia, Qing Zhang and Xi Zhou. https://www.nature.com/articles/s41419-022-05156-2

Caspase-8 auto-cleavage regulates programmed cell death and collaborates with RIPK3/MLKL to prevent lymphopenia – Xiaoming Li, Fang Li, Xixi Zhang, Haiwei Zhang, Qun Zhao, Ming Li, Xiaoxia Wu, Lingxia Wang, Jianling Liu, Xuanhui Wu, Yangjing Ou, Mingyan Xing, Yue Zhang, Jiangshan Deng, Xiuzhe Wang, Yan Luo, Jinbao Li, Yuwu Zhao and Haibing Zhang. https://www.nature.com/articles/s41418-022-00938-9

PKR and TLR3 trigger distinct signals that coordinate the induction of antiviral apoptosis – Wenjie Zuo, Mai Wakimoto, Noriyasu Kozaiwa, Yutaro Shirasaka, Seong-Wook Oh, Shiori Fujiwara, Hitoshi Miyachi, Amane Kogure, Hiroki Kato and Takashi Fujita. https://www.nature.com/articles/s41419-022-05101-3

Necroptosis

Mitochondrial ROS promotes susceptibility to infection via gasdermin D-mediated necroptosis – Chi G. Weindel, Eduardo L. Martinez, Xiao Zhao, Cory J. Mabry, Samantha L. Bell, Krystal J. Vail, Aja K. Coleman, Jordyn J. VanPortfliet, Baoyu Zhao, Allison R. Wagner, Sikandar Azam, Haley M. Scott, Pingwei Li, A. Phillip West, Jason Karpac, Kristin L. Patrick, Robert O. Watson. https://www.cell.com/cell/fulltext/S0092-8674(22)00790-5

ADAR1 mutation causes ZBP1-dependent immunopathology – Nicholas W. Hubbard, Joshua M. Ames, Megan Maurano, Lan H. Chu, Kim Y. Somfleth, Nandan S. Gokhale, Margo Werner, Jessica M. Snyder, Katrina Lichauco, Ram Savan, Daniel B. Stetson and Andrew Oberst. https://www.nature.com/articles/s41586-022-04896-7

ADAR1 averts fatal type I interferon induction by ZBP1 – Huipeng Jiao, Laurens Wachsmuth, Simone Wolf, Juliane Lohmann, Masahiro Nagata, Göksu Gökberk Kaya, Nikos Oikonomou, Vangelis Kondylis, Manuel Rogg, Martin Diebold, Simon E. Tröder, Branko Zevnik, Marco Prinz, Christoph Schell, George R. Young, George Kassiotis and Manolis Pasparakis. https://www.nature.com/articles/s41586-022-04878-9

Deficiency of PPP6C protects TNF-induced necroptosis through activation of TAK1 – Yonggang Zou, Qi Zheng, Bin Jiang, Yuning Liu, Yanhua Xu, Liang Ma, Zonghao Hu, Ming Wu & Hai Song. https://www.nature.com/articles/s41419-022-05076-1

Acidosis induces RIPK1-dependent death of glioblastoma stem cells via acid-sensing ion channel 1a – Jan Clusmann, Klaus-Daniel Cortés Franco, David Alejandro Corredor Suárez, Istvan Katona, Maria Girbes Minguez, Nina Boersch, Karolos-Philippos Pissas, Jakob Vanek, Yuemin Tian and Stefan Gründer. https://www.nature.com/articles/s41419-022-05139-3

Pyroptosis

PP1A prevents ROS‐induced pyroptosis by inhibiting MAPK/caspase‐3 in mouse adipose tissue – Yizhe Chen, Meng Che, Chaowei Li, Yizhou Li, Tiantian Zhang, Xinjian Li, Chao Sun. https://febs.onlinelibrary.wiley.com/doi/abs/10.1111/febs.16373?campaign=woletoc

Ferroptosis

ACSL4-dependent ferroptosis does not represent a tumor-suppressive mechanism but ACSL4 rather promotes liver cancer progression – Julia Grube, Marius Maximilian Woitok, Antje Mohs, Stephanie Erschfeld, Celina Lynen, Christian Trautwein and Tobias Otto. https://www.nature.com/articles/s41419-022-05137-5

G9a dictates neuronal vulnerability to inflammatory stress via transcriptional control of ferroptosis – Nicola Rothammer, Marcel S. Woo, Simone Bauer, Lars Binkle-Ladisch, Giovanni Di Liberto, Kristof Egervari, Ingrid Wagner, Undine Haferkamp, Ole Pless, Doron Merkler, Jan Broder Engler, Manuel A. Friese. https://www.science.org/doi/full/10.1126/sciadv.abm5500

Efferocytosis, entosis etc

Efferocytosis of SARS-CoV-2-infected dying cells impairs macrophage anti-inflammatory functions and clearance of apoptotic cells – Ana CG Salina, Douglas dos-Santos, Tamara S Rodrigues, Marlon Fortes-Rocha, Edismauro G Freitas-Filho, Daniel L Alzamora-Terrel, Icaro MS Castro, Thais FC Fraga da Silva, Mikhael HF de Lima, Daniele C Nascimento, Camila M Silva, Juliana E Toller-Kawahisa, Amanda Becerra, Samuel Oliveira, Diego B Caetité, Leticia Almeida, Adriene Y Ishimoto, Thais M Lima, Ronaldo B Martins, Flavio Veras, Natália B do Amaral, Marcela C Giannini, Letícia P Bonjorno, Maria IF Lopes, Maira N Benatti, Sabrina S Batah, Rodrigo C Santana, Fernando C Vilar, Maria A Martins, Rodrigo L Assad, Sergio CL de Almeida, Fabiola R de Oliveira, Eurico Arruda Neto, Thiago M Cunha, José C Alves-Filho, Vania LD Bonato, Fernando Q Cunha, Alexandre T Fabro, Helder I Nakaya, Dario S Zamboni, Paulo Louzada-Junior, Rene DR Oliveira, Larissa D Cunha. https://elifesciences.org/articles/74443

Glycosylation defects, offset by PEPCK-M, drive entosis in breast carcinoma cells – Petra Hyroššová, Marc Aragó, Cristina Muñoz-Pinedo, Francesc Viñals, Pablo M. García-Rovés, Carmen Escolano, Andrés Méndez-Lucas and Jose C. Perales. https://www.nature.com/articles/s41419-022-05177-x

Externalized phosphatidylinositides on apoptotic cells are eat-me signals recognized by CD14 – Ok-Hee Kim, Geun-Hyung Kang, June Hur, Jinwook Lee, YunJae Jung, In-Sun Hong, Hookeun Lee, Seung-Yong Seo, Dae Ho Lee, Cheol Soon Lee, In-Kyu Lee, Susan Bonner-Weir, Jongsoon Lee, Young Joo Park, Hyeonjin Kim, Steven E. Shoelson and Byung-Chul Oh. https://www.nature.com/articles/s41418-022-00931-2

Apoptotic brown adipocytes enhance energy expenditure via extracellular inosine – Birte Niemann, Saskia Haufs-Brusberg, Laura Puetz, Martin Feickert, Michelle Y. Jaeckstein, Anne Hoffmann, Jelena Zurkovic, Markus Heine, Eva-Maria Trautmann, Christa E. Müller, Anke Tönjes, Christian Schlein, Azin Jafari, Holger K. Eltzschig, Thorsten Gnad, Matthias Blüher, Natalie Krahmer, Peter Kovacs, Joerg Heeren and Alexander Pfeifer. https://www.nature.com/articles/s41586-022-05041-0

Miscellanous

Interaction of LATS1 with SMAC links the MST2/Hippo pathway with apoptosis in an IAP-dependent manner – Lucía García-Gutiérrez, Emma Fallahi, Nourhan Aboud, Niall Quinn & David Matallanas. https://www.nature.com/articles/s41419-022-05147-3

Reviews

Death domain fold proteins in immune signaling and transcriptional regulation – Yu-San Huoh, Sun Hur. https://febs.onlinelibrary.wiley.com/doi/full/10.1111/febs.15901

Regulation of innate immune responses by cell death‐associated caspases during virus infection – Yujie Fang, Ke Peng. https://febs.onlinelibrary.wiley.com/doi/full/10.1111/febs.16051

Restoring TRAILR2/DR5-Mediated Activation of Apoptosis upon Endoplasmic Reticulum Stress as a Therapeutic Strategy in Cancer – Rocío Mora-Molina, Abelardo López-Rivas.. https://www.mdpi.com/1422-0067/23/16/8987

Emerging roles of ferroptosis in the tumor immune landscape: from danger signals to anti‐tumor immunity – Lei Shi, Yingqi Liu, Menghuan Li, Zhong Luo. https://febs.onlinelibrary.wiley.com/doi/full/10.1111/febs.16034

Ferroptosis turns 10: Emerging mechanisms, physiological functions, and therapeutic applications – Brent R. Stockwell. https://www.cell.com/cell/fulltext/S0092-8674(22)00708-5

XIAP as a multifaceted molecule in Cellular Signaling – Mina Hanifeh, Farangis Ataei. https://link.springer.com/article/10.1007/s10495-022-01734-z

Programmed cell death detection methods: a systematic review and a categorical comparison – Sana Kari, Kumar Subramanian, Ilenia Agata Altomonte, Akshaya Murugesan, Olli Yli-Harja, Meenakshisundaram Kandhavelu. https://link.springer.com/article/10.1007/s10495-022-01735-y

Comments / other

Remembering apoptosis pioneer Andrew Wyllie (1944–2022) – Christine J. Watson, Gerry Melino, Seamus J. Martin. https://febs.onlinelibrary.wiley.com/doi/full/10.1111/febs.16566

Hold your horses! Reining in your fastest pores with caspase-7 – Jeffrey Y. Zhou, Katherine A. Fitzgerald. https://www.cell.com/immunity/fulltext/S1074-7613(22)00348-X

RIPK1 Promotes Intrinsic and Extrinsic Resistance to Immunotherapy. https://aacrjournals.org/cancerdiscovery/article-abstract/12/7/1607/705209

Lab Meeting: Vishva Dixit. https://dneel.substack.com/p/lab-meeting-vishva-dixit?r=1m5xy3&utm_medium=ios

Conference: “Problems in the Powerhouse: Mitochondrial Dysfunction in Cancer”

Oct. 24/25^th. Organizers: Payam Gammage, Stephen Tait , Tom MacVicar. Glasgow, UK

https://www.beatson.gla.ac.uk/Beatson-Workshop-October-2022/programme.html

July 4, 2022 cris

ApoList – June 2022

Caspases

Caspase-7 activates ASM to repair gasdermin and perforin pores – Kengo Nozaki, Vivien I. Maltez, Manira Rayamajhi, Alan L. Tubbs, Joseph E. Mitchell, Carolyn A. Lacey, Carissa K. Harvest, Lupeng Li, William T. Nash, Heather N. Larson, Benjamin D. McGlaughon, Nathaniel J. Moorman, Michael G. Brown, Jason K. Whitmire and Edward A. Miao. https://www.nature.com/articles/s41586-022-04825-8

Caspase‐8 in endothelial cells maintains gut homeostasis and prevents small bowel inflammation in mice – Nathalie Tisch, Carolin Mogler, Ana Stojanovic, Robert Luck, Emilia A Korhonen, Alexander Ellerkmann, Heike Adler, Mahak Singhal, Géza Schermann, Lena Erkert, Jay V Patankar, Andromachi Karakatsani, Anna-Lena Scherr, Yaron Fuchs, Adelheid Cerwenka, Stefan Wirtz, Bruno Christian Köhler, Hellmut G Augustin, Christoph Becker, Thomas Schmidt, Carmen Ruiz de Almodóvar. https://www.embopress.org/doi/full/10.15252/emmm.202114121

Myeloid caspase-8 restricts RIPK3-dependent proinflammatory IL-1β production and CD4 T cell activation in autoimmune demyelination – Sunja Kim, Hsueh Chung Lu, Andrew J. Steelman and Jianrong Li. https://www.pnas.org/doi/10.1073/pnas.2117636119

Cytoplasmic innate immune sensing by the caspase-4 non-canonical inflammasome promotes cellular senescence – Irene Fernández-Duran, Andrea Quintanilla, Núria Tarrats, Jodie Birch, Priya Hari, Fraser R. Millar, Anthony B. Lagnado, Vanessa Smer-Barreto, Morwenna Muir, Valerie G. Brunton, João F. Passos and Juan Carlos Acosta. https://www.nature.com/articles/s41418-021-00917-6

Mechanistic insights into the activation of the IKK kinase complex by the Kaposi’s sarcoma herpes virus oncoprotein vFLIP – Claire Bagnéris, Swathi L. Senthil Kumar, Mehdi Baratchian, Hannah M. Britt, Tufa E. Assafa, Konstantinos Thalassinos, Mary K. Collins, Tracey E. Barrett. https://www.jbc.org/article/S0021-9258(22)00452-5/fulltext

Necroptosis

Human RIPK3 C-lobe phosphorylation is essential for necroptotic signaling – Yanxiang Meng, Christopher R. Horne, Andre L. Samson, Laura F. Dagley, Samuel N. Young, Jarrod J. Sandow, Peter E. Czabotar and James M. Murphy. https://www.nature.com/articles/s41419-022-05009-y

Pyroptosis

Nanobodies dismantle post‐pyroptotic ASC specks and counteract inflammation in vivo – Damien Bertheloot, Carlos WS Wanderley, Ayda H Schneider, Lisa DJ Schiffelers, Jennifer D Wuerth, Jan MP Tödtmann, Salie Maasewerd, Ibrahim Hawwari, Fraser Duthie, Cornelia Rohland, Lucas S Ribeiro, Lea-Marie Jenster, Nathalia Rosero, Yonas M Tesfamariam, Fernando Q Cunha, Florian I Schmidt, Bernardo S Franklin. https://www.embopress.org/doi/full/10.15252/emmm.202115415

Targeting of GSDMD sensitizes HCC to anti-PD-1 by activating cGAS pathway and downregulating PD-L1 expression – Tingting Lv, Xiaofeng Xiong, Wei Yan, Mei Liu, Hongwei Xu and Qin He. https://jitc.bmj.com/content/10/6/e004763

Ferroptosis

Cancer cells dying from ferroptosis impede dendritic cell-mediated anti-tumor immunity – Bartosz Wiernicki, Sophia Maschalidi, Jonathan Pinney, Sandy Adjemian, Tom Vanden Berghe, Kodi S. Ravichandran and Peter Vandenabeele. https://www.nature.com/articles/s41467-022-31218-2

Ferroptosis mediates selective motor neuron death in amyotrophic lateral sclerosis – Taide Wang, Doris Tomas, Nirma D. Perera, Brittany Cuic, Sophia Luikinga, Aida Viden, Samantha K. Barton, Catriona A. McLean, André L. Samson, Adam Southon, Ashley I. Bush, James M. Murphy and Bradley J. Turner. https://www.nature.com/articles/s41418-021-00910-z

A ferroptosis defense mechanism mediated by glycerol-3-phosphate dehydrogenase 2 in mitochondria – Shiqi Wu, Chao Mao, Lavanya Kondiparthi, Masha V. Poyurovsky, Kellen Olszewski and Boyi Gan. https://www.pnas.org/doi/10.1073/pnas.2121987119

Miscellanous

Optogenetic activators of apoptosis, necroptosis, and pyroptosis – Kateryna Shkarina, Eva Hasel de Carvalho, José Carlos Santos, Saray Ramos, Maria Leptin, Petr Broz. https://rupress.org/jcb/article/221/6/e202109038/213145

DRP1 levels determine the apoptotic threshold during embryonic differentiation through a mitophagy-dependent mechanism – Barbara Pernaute, Salvador Pérez-Montero, Juan Miguel Sánchez Nieto, Aida Di Gregorio, Ana Lima, Katerina Lawlor, Sarah Bowling, Gianmaria Liccardi, Alejandra Tomás, Pascal Meier, Hiromi Sesaki, Guy A. Rutter, Ivana Barbaric, Tristan A. Rodríguez. https://www.cell.com/developmental-cell/fulltext/S1534-5807(22)00306-9

A signature for pan-cancer prognosis based on neutrophil extracellular traps – Yi Zhang, Liping Guo, Qichen Dai, Bingqing Shang, Ting Xiao, Xuebing Di, Kaitai Zhang, Lin Feng, Jianzhong Shou and Yipeng Wang. https://jitc.bmj.com/content/10/6/e004210

TIR domains of plant immune receptors are 2′,3′-cAMP/cGMP synthetases mediating cell death – Dongli Yu, Wen Song, Eddie Yong Jun Tan, Li Liu, Yu Cao, Jan Jirschitzka, Ertong Li, Elke Logemann, Chenrui Xu, Shijia Huang, Aolin Jia, Xiaoyu Chang, Zhifu Han, Bin Wu, Paul Schulze-Lefert, Jijie Chai. https://www.cell.com/cell/fulltext/S0092-8674(22)00530-X

Reviews

What can we learn from mice lacking pro-survival BCL-2 proteins to advance BH3 mimetic drugs for cancer therapy? – Kerstin Brinkmann, Ashley P. Ng, Carolyn A. de Graaf and Andreas Strasser. https://www.nature.com/articles/s41418-022-00987-0

Paradoxical roles of caspase-3 in regulating cell survival, proliferation, and tumorigenesis – Ebrahim Eskandari, Connie J. Eaves. https://rupress.org/jcb/article/221/6/e202201159/213213

Structural Details of BH3 Motifs and BH3-Mediated Interactions: an Updated Perspective – Valentina Sora and Elena Papaleo. https://www.frontiersin.org/articles/10.3389/fmolb.2022.864874/full

Ferroptosis at the intersection of lipid metabolism and cellular signaling – Deguang Liang, Alexander M. Minikes, Xuejun Jiang. https://www.cell.com/molecular-cell/fulltext/S1097-2765(22)00260-X

Cell Death-Related Ubiquitin Modifications in Inflammatory Syndromes: From Mice to Men – Nieves Peltzer and Alessandro Annibaldi. https://www.mdpi.com/2227-9059/10/6/1436

Comments

Killing cells using light (activated) sabers – Stephen W.G. Tait. https://rupress.org/jcb/article/221/6/e202205018/213218

BAX and BAK dynamics control mitochondrial DNA release during apoptosis – Takahiro Yamazaki and Lorenzo Galluzzi. https://www.nature.com/articles/s41418-022-00985-2