ApoList – June 2019


Bcl-2 family proteins

A non‐death function of the mitochondrial apoptosis apparatus in immunity – Dominik Brokatzky, Benedikt Dörflinger, Aladin Haimovici, Arnim Weber, Susanne Kirschnek, Juliane Vier,Arlena Metz, Julia Henschel, Tobias Steinfeldt, Ian E Gentle, Georg Häcker. https://www.embopress.org/doi/10.15252/embj.2018100907

Structures of BCL-2 in complex with venetoclax reveal the molecular basis of resistance mutations – Richard W. Birkinshaw, Jia-nan Gong, Cindy S. Luo, Daisy Lio, Christine A. White, Mary Ann Anderson, Piers Blombery, Guillaume Lessene, Ian J. Majewski, Rachel Thijssen, Andrew W. Roberts, David C. S. Huang, Peter M. Colman and Peter E. Czabotar. https://www.nature.com/articles/s41467-019-10363-1

α7 nicotinic acetylcholine receptor upregulation by anti-apoptotic Bcl-2 proteins – Brent Dawe, Hong Yu, Shenyan Gu, Alissa N. Blackler, Jose A. Matta, Edward R. Siuda, Elizabeth B. Rex and David S. Bredt. https://www.nature.com/articles/s41467-019-10723-x

Impact of elevated anti-apoptotic MCL-1 and BCL-2 on the development and treatment of MLL-AF9 AML in mice – Natasha S. Anstee, Rebecca A. Bilardi, Ashley P. Ng, Zhen Xu, Mikara Robati, Cassandra J. Vandenberg and Suzanne Cory. https://www.nature.com/articles/s41418-018-0209-1

Alcohol exposure alters pre-mRNA splicing of antiapoptotic Mcl-1L isoform and induces apoptosis in neural progenitors and immature neurons – Martina Donadoni, Stephanie Cicalese, Dipak K. Sarkar, Sulie L. Chang and Ilker Kudret Sariyer. https://www.nature.com/articles/s41419-019-1673-3

Resistance to anti-microtubule drug-induced cell death is determined by regulation of BimEL expression – Weimei Ruan, Gireedhar Venkatachalam, Radoslaw Mikolaj Sobota, Liyan Chen, Loo Chien Wang, Alena Jacobson, Kathirvel Paramasivam and Uttam Surana. https://www.nature.com/articles/s41388-019-0727-4

MiR-35 buffers apoptosis thresholds in the C. elegans germline by antagonizing both MAPK and core apoptosis pathways – Anh T. Tran, Eric M. Chapman, Mathieu N. Flamand, Bin Yu, Samuel J. Krempel, Thomas F. Duchaine, Matthew Eroglu and W. Brent Derry. https://www.nature.com/articles/s41418-019-0325-6

XPO1 inhibitor KPT-330 synergizes with Bcl-xL inhibitor to induce cancer cell apoptosis by perturbing rRNA processing and Mcl-1 protein synthesis – Zhi-Chuan Zhu, Ji-Wei Liu, Can Yang, Miao Zhao and Zhi-Qi Xiong. https://www.nature.com/articles/s41419-019-1627-9

Death receptors

DR4-Ser424 O-GlcNAcylation Promotes Sensitization of TRAIL-Tolerant Persisters and TRAIL-Resistant Cancer Cells to Death – Hyeonjeong Lee, Yumin Oh, Young-Jun Jeon, Song-Yi Lee, Hyunjoo Kim, Ho-June Lee and Yong-Keun Jung. http://cancerres.aacrjournals.org/content/79/11/2839

c-FLIP and CD95 signaling are essential for survival of renal cell carcinoma – Tobias Luebke, Lisa Schwarz, Yan Yan Beer, Sabrina Schumann, Maria Misterek, Frida Ewald Sander, Carlos Plaza-Sirvent and Ingo Schmitz. https://www.nature.com/articles/s41419-019-1609-y


Molecular basis of dimerization of initiator caspase was revealed by crystal structure of caspase-8 pro-domain – Hyun Ho Par. https://www.nature.com/articles/s41418-018-0200-x

Caspase-8 promotes c-Rel–dependent inflammatory cytokine expression and resistance against Toxoplasma gondii – Alexandra A. DeLaney, Corbett T. Berry, David A. Christian, Andrew Hart, Elisabet Bjanes, Meghan A. Wynosky-Dolfi, Xinyuan Li, Bart Tummers, Irina A. Udalova, Youhai H. Chen, Uri Hershberg, Bruce D. Freedman, Christopher A. Hunter and Igor E. Brodsky. https://www.pnas.org/content/116/24/11926.abstract?etoc

Gasdermin-D and Caspase-7 are the key Caspase-1/8 substrates downstream of the NAIP5/NLRC4 inflammasome required for restriction of Legionella pneumophila – Augusto V. Gonçalves, Shally R. Margolis , Gustavo F. S. Quirino, Danielle P. A. Mascarenhas, Isabella Rauch, Randilea D. Nichols, Eduard Ansaldo, May F. Fontana, Russell E. Vance and Dario S. Zamboni. https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1007886


Necroptosis mediators RIPK3 and MLKL suppress intracellular Listeria replication independently of host cell killing – Kazuhito Sai, Cameron Parsons, John S. House, Sophia Kathariou and Jun Ninomiya-Tsuji. http://jcb.rupress.org/content/218/6/1994

Discovery of potent necroptosis inhibitors targeting RIPK1 kinase activity for the treatment of inflammatory disorder and cancer metastasis – Jue Hou, Jie Ju, Zili Zhang, Cong Zhao, Zhanhui Li, Jiyue Zheng, Tian Sheng, Hongjian Zhang, Linkun Hu, Xiaoliang Yu, Wei Zhang, Yangxin Li, Meng Wu, Haikuo Ma, Xiaohu Zhang and Sudan He. https://www.nature.com/articles/s41419-019-1735-6

FKBP12 mediates necroptosis by initiating RIPK1–RIPK3–MLKL signal transduction in response to TNF receptor 1 ligation – Zicheng Wang, Jiannan Feng, Jiyun Yu and Guozhu Chen. http://jcs.biologists.org/content/132/10/jcs227777?etoc

Interferon-γ induces the cell surface exposure of phosphatidylserine by activating MLKL in the absence of caspase-8 activity – Jiancheng Chen, Shunsuke Kuroki, Masataka Someda and Shin Yonehara. http://www.jbc.org/content/early/2019/06/19/jbc.RA118.007161.abstract


Ferroptotic cell death and TLR4/Trif signaling initiate neutrophil recruitment after heart transplantation – Wenjun Li, Guoshuai Feng, Jason M. Gauthier, Inessa Lokshina, Ryuji Higashikubo, Sarah Evans, Xinping Liu, Adil Hassan, Satona Tanaka, Markus Cicka, Hsi-Min Hsiao, Daniel Ruiz-Perez, Andrea Bredemeyer, Richard W. Gross, Douglas L. Mann, Yulia Y. Tyurina, Andrew E. Gelman, Valerian E. Kagan, Andreas Linkermann, Kory J. Lavine and Daniel Kreisel. https://www.jci.org/articles/view/126428


A conserved CCM complex promotes apoptosis non-autonomously by regulating zinc homeostasis – Eric M. Chapman, Benjamin Lant, Yota Ohashi, Bin Yu, Michael Schertzberg, Christopher Go, Deepika Dogra, Janne Koskimäki, Romuald Girard, Yan Li, Andrew G. Fraser, Issam A. Awad, Salim Abdelilah-Seyfried, Anne-Claude Gingras and W. Brent Derry. https://www.nature.com/articles/s41467-019-09829-z

Discerning the mechanism of action of HtrA4: a serine protease implicated in the cell death pathway – Raghupathi Kummari, Shubhankar Dutta, Lalith K. Chaganti and Kakoli Bose. http://www.biochemj.org/content/476/10/1445?etoc

AIF-regulated oxidative phosphorylation supports lung cancer development – Shuan Rao, Laura Mondragón, Blanka Pranjic, Toshikatsu Hanada, Gautier Stoll, Thomas Köcher, Peng Zhang, Alexander Jais, Alexander Lercher, Andreas Bergthaler, Daniel Schramek, Katharina Haigh, Valentina Sica, Marion Leduc, Nazanine Modjtahedi, Tsung-Pin Pai, Masahiro Onji, Iris Uribesalgo, Reiko Hanada, Ivona Kozieradzki, Rubina Koglgruber, Shane J. Cronin, Zhigang She, Franz Quehenberger, Helmut Popper, Lukas Kenner, Jody J. Haigh, Oliver Kepp, Malgorzata Rak, Kaican Cai, Guido Kroemer and Josef M. Penninger. https://www.nature.com/articles/s41422-019-0181-4


Caspases in Cell Death, Inflammation, and Disease – Nina Van Opdenbosch, Mohamed Lamkanfi. https://www.cell.com/immunity/fulltext/S1074-7613(19)30240-7

Targeting Ferroptosis to Iron Out Cancer – Behrouz Hassannia, Peter Vandenabeele, Tom Vanden Berghe. https://www.cell.com/cancer-cell/fulltext/S1535-6108(19)30197-7

Ferroptosis at the crossroads of cancer-acquired drug resistance and immune evasion – José Pedro Friedmann Angeli, Dmitri V. Krysko and Marcus Conrad. https://www.nature.com/articles/s41568-019-0149-1

Molecular Comprehension of Mcl-1: From Gene Structure to Cancer Therapy – Viacheslav V. Senichkin, Alena Y. Streletskaia, Boris Zhivotovsky, Gelina S. Kopeina. https://www.cell.com/trends/cell-biology/fulltext/S0962-8924(19)30047-9

Autophagy-Independent Functions of the Autophagy Machinery – Lorenzo Galluzzi, Douglas R. Green. https://www.cell.com/cell/fulltext/S0092-8674(19)30554-9

FAIM: An Antagonist of Fas-Killing and Beyond – Jianxin Huo, Shengli Xu and Kong-Peng Lam. https://www.mdpi.com/2073-4409/8/6/541


Mitochondria and pathogen immunity: from killer to firestarter – Joel S Riley, Stephen WG Tait. https://www.embopress.org/doi/full/10.15252/embj.2019102325

Bayonets over bombs: RIPK3 and MLKL restrict Listeria without triggering necroptosis – Ting Zhang, Siddharth Balachandran. http://jcb.rupress.org/content/218/6/1773?etoc

A New Current for the Mitochondrial Permeability Transition – Massimo Bonora, Paolo Pinton. https://www.cell.com/trends/biochemical-sciences/fulltext/S0968-0004(19)30089-1

Cell Death: N-degrons Fine-Tune Pyroptotic Cell Demise – Mohamed A. Eldeeb, Mohamed A. Ragheb, Edward A. Fon. https://www.cell.com/current-biology/fulltext/S0960-9822(19)30537-8

Death Is Coming and the Clot Thickens, as Pyroptosis Feeds the Fire – Laura C. Burzynski, Murray C.H. Clarke. https://www.cell.com/immunity/fulltext/S1074-7613(19)30235-3

Cancer and the death domain – Wei Wong. https://stke.sciencemag.org/content/12/584/eaay2357


Bax channel triplet: co-operativity and voltage gating – Shang H. Lin, Nuval Cherian, Benjamin Wu, Hyo Phee, Christy Cho and Marco Colombini. http://www.biochemj.org/content/476/10/1571?etoc


ApoList – May 2019


Bcl-2 family proteins

BCL2 Amplicon Loss and Transcriptional Remodeling Drives ABT-199 Resistance in B Cell Lymphoma Models – Xiaohong Zhao, Yuan Ren, Matthew Lawlor, Bijal D. Shah, Paul M.C. Park, Tint Lwin, Xuefeng Wang, Kenian Liu, Michelle Wang, Jing Gao, Tao Li, Mousheng Xu, Ariosto S. Silva, Kaplan Lee, Tinghu Zhang, John M. Koomen, Huijuan Jiang, Praneeth R. Sudalagunta, Mark B. Meads, Fengdong Cheng, Chengfeng Bi, Kai Fu, Huitao Fan, William S. Dalton, Lynn C. Moscinski, Kenneth H. Shain, Eduardo M. Sotomayor, Gang Greg Wang, Nathanael S. Gray, John L. Cleveland, Jun Qi, Jianguo Tao. https://www.cell.com/cancer-cell/fulltext/S1535-6108(19)30200-4

Retromer facilitates the localization of Bcl-xL to the mitochondrial outer membrane – Trey Farmer, Katelyn L. O’Neill, Naava Naslavsky, Xu Luo and Steve Caplan. https://www.molbiolcell.org/doi/10.1091/mbc.E19-01-0044?ai=s5&ui=2oy6&af=T

Bcl-2 Is a Therapeutic Target for Hypodiploid B-Lineage Acute Lymphoblastic Leukemia – Ernesto Diaz-Flores, Evan Q. Comeaux, Kailyn L. Kim, Ella Melnik, Kyle Beckman, Kara L. Davis, Kevin Wu, Jon Akutagawa, Olga Bridges, Roberta Marino, Margo Wohlfeil, Benjamin S. Braun, Charles G. Mullighan and Mignon L. Loh. http://cancerres.aacrjournals.org/content/79/9/2339

Venetoclax plus R- or G-CHOP in non-Hodgkin lymphoma: results from the CAVALLI phase 1b trial – Andrew D. Zelenetz, Gilles Salles, Kylie D. Mason, Carla Casulo, Steven Le Gouill, Laurie H. Sehn, Herve Tilly, Guillaume Cartron, Martine E. D.  Chamuleau, Andre Goy, Constantine S. Tam, Pieternella J. Lugtenburg, Adam M. Petrich, Arijit Sinha, Divya Samineni, Sylvia Herter, Ellen Ingalla,  Edith Szafer-Glusman, Christian Klein, Deepak Sampath, Martin Kornacker, Mehrdad Mobasher and Franck Morschhauser. http://bloodjournal.org/content/133/18/1964.abstract?etoc

BCL-XL and MCL-1 are the key BCL-2 family proteins in melanoma cell survival – Erinna F. Lee, Tiffany J. Harris, Sharon Tran, Marco Evangelista, Surein Arulananda, Thomas John, Celeste Ramnac, Chloe Hobbs, Haoran Zhu, Gency Gunasingh, David Segal, Andreas Behren, Jonathan Cebon, Alexander Dobrovic, John M. Mariadason, Andreas Strasser, Leona Rohrbeck, Nikolas K. Haass, Marco J. Herold and W. Douglas Fairlie. https://www.nature.com/articles/s41419-019-1568-3

Non-canonical BAD activity regulates breast cancer cell and tumor growth via 14-3-3 binding and mitochondrial metabolism – Jasdeep Mann, John Maringa Githaka, Timothy W. Buckland, Ning Yang, Rachel Montpetit, Namrata Patel, Lei Li, Shairaz Baksh, Roseline Godbout, Hélène Lemieux and Ing Swie Goping. https://www.nature.com/articles/s41388-018-0673-6

Death receptors / IAPs / caspases

Ubiquitin Ligases cIAP1 and cIAP2 Limit Cell Death to Prevent Inflammation – Jieqiong Zhang, Joshua D. Webster, Debra L. Dugger, Tatiana Goncharov, Merone Roose-Girma, Jeffrey Hung, Youngsu C. Kwon, Domagoj Vucic, Kim Newton, Vishva M. Dixit. https://www.cell.com/cell-reports/fulltext/S2211-1247(19)30601-1

RUNX3 enhances TRAIL-induced apoptosis by upregulating DR5 in colorectal cancer – Bo Ram Kim, Seong Hye Park, Yoon A Jeong, Yoo Jin Na, Jung Lim Kim, Min Jee Jo, Soyeon Jeong, Hye Kyeong Yun, Sang Cheul Oh and Dae-Hee Lee. https://www.nature.com/articles/s41388-019-0693-x

Regulation of death receptor signaling by the autophagy protein TP53INP2 – Saška Ivanova, Mira Polajnar, Alvaro Jesus Narbona‐Perez, Maria Isabel Hernandez‐Alvarez, Petra Frager, Konstantin Slobodnyuk, Natalia Plana, Angel R Nebreda, Manuel Palacin, Roger R Gomis, Christian Behrends and Antonio Zorzano. http://EMBOJ.embopress.org/content/38/10/e99300

CrmA orthologs from diverse poxviruses potently inhibit caspases-1 and -8, yet cleavage site mutagenesis frequently produces caspase-1-specific variants – David T. Bloomer, Tanja Kitevska-Ilioski, Delara Pantaki-Eimany, Yanhao Ji, Mark A. Miles, Begona Heras and Christine J. Hawkins. http://www.biochemj.org/content/476/9/1335?etoc


IRF2 transcriptionally induces GSDMD expression for pyroptosis – Nobuhiko Kayagaki, Bettina L. Lee, Irma B. Stowe, Opher S. Kornfeld, Karen O’Rourke, Kathleen M. Mirrashidi, Benjamin Haley, Colin Watanabe, Merone Roose-Girma, Zora Modrusan, Sarah Kummerfeld, Rohit Reja, Yafei Zhang, Vicky Cho, T. Daniel Andrews, Lucy X. Morris, Christopher C. Goodnow, Edward M. Bertram and Vishva M. Dixit. https://stke.sciencemag.org/content/12/582/eaax4917

Caspase-1 initiates apoptosis in the absence of gasdermin D – Kohsuke Tsuchiya, Shinsuke Nakajima, Shoko Hosojima, Dinh Thi Nguyen, Tsuyoshi Hattori, Thuong Manh Le, Osamu Hori, Mamunur Rashid Mahib, Yoshifumi Yamaguchi, Masayuki Miura, Takeshi Kinoshita, Hiroko Kushiyama, Mayumi Sakurai, Toshihiko Shiroishi and Takashi Suda. https://www.nature.com/articles/s41467-019-09753-2

Extrinsic and intrinsic apoptosis activate pannexin‐1 to drive NLRP3 inflammasome assembly – Kaiwen W Chen, Benjamin Demarco, Rosalie Heilig, Kateryna Shkarina, Andreas Boettcher, Christopher J Farady, Pawel Pelczar and Petr Broz. http://EMBOJ.embopress.org/content/38/10/e101638?etoc

Diverse small molecules prevent macrophage lysis during pyroptosis – Wendy P. Loomis, Andreas B. den Hartigh, Brad T. Cookson and Susan L. Fink. https://www.nature.com/articles/s41419-019-1559-4


RIP1 inhibition blocks inflammatory diseases but not tumor growth or metastases – Snahel Patel, Joshua D. Webster, Eugene Varfolomeev, Youngsu C. Kwon, Jason H. Cheng, Juan Zhang, Debra L. Dugger, Kate E. Wickliffe, Allie Maltzman, Swathi Sujatha-Bhaskar, Pawan Bir Kohli, Sreema Ramaswamy, Gauri Deshmukh, Bianca M. Liederer, Rina Fong, Greg Hamilton, Patrick Lupardus, Patrick Caplazi, Wyne P. Lee, Menno van Lookeren Campagne, Adam Johnson, Brent S. McKenzie, Melissa R. Junttila, Kim Newton and Domagoj Vucic. https://www.nature.com/articles/s41418-019-0347-0

TRAF2 protects against cerebral ischemia-induced brain injury by suppressing necroptosis – Jie Li, Jingyu Zhang, Yusuo Zhang, Zichuang Wang, Yanmei Song, Shanwen Wei, Meijun He, Shoujiang You, Jia Jia and Jian Cheng. https://www.nature.com/articles/s41419-019-1558-5

Flotillin-mediated endocytosis and ALIX–syntenin-1–mediated exocytosis protect the cell membrane from damage caused by necroptosis – Weiliang Fan, Jia Guo, Beichen Gao, Wenbin Zhang, Liucong Ling, Tao Xu, Chenjie Pan, Lin Li, She Chen, Hua Wang, Jing Zhang and Xiaodong Wang. https://stke.sciencemag.org/content/12/583/eaaw3423


CD8+ T cells regulate tumour ferroptosis during cancer immunotherapy – Weimin Wang, Michael Green, Jae Eun Choi, Miguel Gijón, Paul D. Kennedy, Jeffrey K. Johnson, Peng Liao, Xueting Lang, Ilona Kryczek, Amanda Sell, Houjun Xia, Jiajia Zhou, Gaopeng Li, Jing Li, Wei Li, Shuang Wei, Linda Vatan, Hongjuan Zhang, Wojciech Szeliga, Wei Gu, Rebecca Liu, Theodore S. Lawrence, Candice Lamb, Yuri Tanno, Marcin Cieslik, Everett Stone, George Georgiou, Timothy A. Chan, Arul Chinnaiyan and Weiping Zou. https://www.nature.com/articles/s41586-019-1170-y

ALOX12 is required for p53-mediated tumour suppression through a distinct ferroptosis pathway – Bo Chu, Ning Kon, Delin Chen, Tongyuan Li, Tong Liu, Le Jiang, Shujuan Song, Omid Tavana and Wei Gu. https://www.nature.com/articles/s41556-019-0305-6

Curcumin reduces renal damage associated with rhabdomyolysis by decreasing ferroptosis-mediated cell death – Melania Guerrero-Hue, Cristina García-Caballero, Alejandra Palomino-Antolín, Alfonso Rubio-Navarro, Cristina Vázquez-Carballo, Carmen Herencia, Diego Martín-Sanchez, Víctor Farré-Alins, Javier Egea, Pablo Cannata, Manuel Praga, Alberto Ortiz, Jesús Egido, Ana Belén Sanz and Juan Antonio Moreno. https://www.fasebj.org/doi/abs/10.1096/fj.201900077R?ai=ts&ui=ly8&af=T


Analysis of extracellular vesicles generated from monocytes under conditions of lytic cell death – Amy A. Baxter, Thanh Kha Phan, Eric Hanssen, Michael Liem, Mark D. Hulett, Suresh Mathivanan and Ivan K. H. Poon. https://www.nature.com/articles/s41598-019-44021-9

Necrosis, apoptosis, necroptosis, three modes of action of dopaminergic neuron neurotoxins – Noëlle Callizot, Maud Combes, Alexandre Henriques, Philippe Poindron. https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215277

Drosophila p53 directs nonapoptotic programs in postmitotic tissue – Paula Kurtz, Amanda E. Jones, Bhavana Tiwari, Nichole Link, Annika Wylie, Charles Tracy, Helmut Krämer and John M. Abrams. https://www.molbiolcell.org/doi/10.1091/mbc.E18-12-0791?ai=s5&ui=2oy6&af=T


The Coming Decade of Cell Death Research: Five Riddles – Douglas R. Green. https://www.cell.com/cell/fulltext/S0092-8674(19)30443-X

Targeting RIPK1 for the treatment of human diseases – Alexei Degterev, Dimitry Ofengeim and Junying Yuan. https://www.pnas.org/content/116/20/9714.abstract

Modulation of CD95-mediated signaling by post-translational modifications: towards understanding CD95 signaling networks – Kamil Seyrek and Inna N. Lavrik. https://link.springer.com/article/10.1007/s10495-019-01540-0

The role of necroptosis in cancer: A double-edged sword? – Xia Qin, Dan Ma, Ye-xiong Tan, Hong-yang Wang, Zhenyu Cai. https://www.sciencedirect.com/science/article/abs/pii/S0304419X18302105


Chopping GSDMD: caspase‐8 has joined the team of pyroptosis‐mediating caspases – Anna M Gram, Lee M Booty and Clare E Bryant. http://EMBOJ.embopress.org/content/38/10/e102065?etoc

Venetoclax: R-CHOP rocket booster? – Charles Herbaux and Matthew S. Davids. http://bloodjournal.org/content/133/18/1922?etoc

Potential role of anastasis in cancer initiation and progression – Thirumal Raj, Supriya Kheur, Ramesh Bhonde, Archana A. Gupta, Vikrant R. Patil and Avinash Kharat. https://link.springer.com/article/10.1007/s10495-019-01538-8

Targeting MCL1, Companies Aim to Unblock Apoptosis – http://cancerdiscovery.aacrjournals.org/content/9/5/572

Venetoclax–Obinutuzumab Elicits High Response Rates in CLL – http://cancerdiscovery.aacrjournals.org/content/9/5/OF5

ApoList – April 2019

If wish to subscribe please visit the following link – http://eepurl.com/cvmBlv

Mitochondrial pathway

Gasdermin pores permeabilize mitochondria to augment caspase-3 activation during apoptosis and inflammasome activation – Corey Rogers, Dan A. Erkes, Alexandria Nardone, Andrew E. Aplin, Teresa Fernandes-Alnemri and Emad S. Alnemri. https://www.nature.com/articles/s41467-019-09397-2

Intrinsic apoptosis shapes the tumor spectrum linked to inactivation of the deubiquitinase BAP1 – Meng He, Mira S. Chaurushiya, Joshua D. Webster, Sarah Kummerfeld, Rohit Reja, Subhra Chaudhuri, Ying-Jiun Chen, Zora Modrusan, Benjamin Haley, Debra L. Dugger, Jeffrey Eastham-Anderson, Shari Lau, Anwesha Dey, Roger Caothien, Merone Roose-Girma, Kim Newton, Vishva M. Dixit. https://science.sciencemag.org/content/364/6437/283.abstract

Cytochrome c Deficiency Confers Apoptosome and Mitochondrial Dysfunction in African-American Men with Prostate Cancer – Rahul Kumar, Tariq A. Bhat, Elise M. Walsh, Ajay K. Chaudhary, Jordan O’Malley, Johng S. Rhim, Jianmin Wang, Carl D. Morrison, Kristopher Attwood, Wiam Bshara, James L. Mohler, Neelu Yadav and Dhyan Chandra. http://cancerres.aacrjournals.org/content/79/7/1353

Ceramides bind VDAC2 to trigger mitochondrial apoptosis – Shashank Dadsena, Svenja Bockelmann, John G. M. Mina, Dina G. Hassan, Sergei Korneev, Guilherme Razzera, Helene Jahn, Patrick Niekamp, Dagmar Müller, Markus Schneider, Fikadu G. Tafesse, Siewert J. Marrink, Manuel N. Melo and Joost C. M. Holthuis. https://www.nature.com/articles/s41467-019-09654-4

Mitochondrial pathway – Bcl-2 family proteins

BAX Activation: Mutations Near Its Proposed Non-canonical BH3 Binding Site Reveal Allosteric Changes Controlling Mitochondrial Association – Michael A. Dengler, Adeline Y. Robin, Leonie Gibson, Mark X. Li, Jarrod J. Sandow, Sweta Iyer, Andrew I. Webb, Dana Westphal, Grant Dewson, Jerry M. Adams. https://www.cell.com/cell-reports/fulltext/S2211-1247(19)30356-0

Bcl-2 and IP3 compete for the ligand-binding domain of IP3Rs modulating Ca2+ signaling output – Hristina Ivanova, Larry E. WagnerII, Akihiko Tanimura, Elien Vandermarliere, Tomas Luyten, Kirsten Welkenhuyzen, Kamil J. Alzayady, Liwei Wang, Kozo Hamada, Katsuhiko Mikoshiba, Humbert De Smedt, Lennart Martens, David I. Yule, Jan B. Parys, Geert Bultynck. https://link.springer.com/article/10.1007/s00018-019-03091-8

Discovery of Potent Myeloid Cell Leukemia-1 (Mcl-1) Inhibitors that Demonstrate in vivo Activity in Mouse Xenograft Models of Human Cancer – Lee T, Christov PP, Shaw S, Tarr JC, Zhao B, Veerasamy N, Jeon KO, Mills JJ, Bian Z, Sensintaffar JL, Arnold AL, Fogarty SA, Perry E, Ramsey HE, Cook R, Hollingshead M, Davis Millin M, Lee KM, Koss B, Budhraja A, Opferman JT, Kim K, Arteaga CL, Moore WJ, Olejniczak ET, Savona MR, Fesik SW. https://pubs.acs.org/doi/10.1021/acs.jmedchem.8b01991

Structural insights into BCL2 pro-survival protein interactions with the key autophagy regulator BECN1 following phosphorylation by STK4/MST1 – Erinna F. Lee, Nicholas A. Smith, Tatiana P. Soares da Costa, Nastaran Meftahi, Shenggen Yao, Tiffany J. Harris, Sharon Tran, Anne Pettikiriarachchi, Matthew A. Perugini, David W. Keizer, Marco Evangelista, Brian J. Smith and W. Douglas Fairlie. https://www.tandfonline.com/doi/full/10.1080/15548627.2018.1564557

Avoiding adsorption of Bcl-2 proteins to plasticware is important for accurate quantitation – Colin Hockings, Sweta Iyer, Rachel T. Uren and Ruth M. Kluck. https://www.nature.com/articles/s41418-019-0284-y

Interactions between cancer-associated fibroblasts and tumor cells promote MCL-1 dependency in estrogen receptor-positive breast cancers – Louault, T. L Bonneaud, C. Séveno, P. Gomez-Bougie, F. Nguyen, F. Gautier, N. Bourgeois, D. Loussouarn, O. Kerdraon, S. Barillé-Nion, P. Jézéquel, M. Campone, M. Amiot, P. P. Juin and F. Souazé. https://www.nature.com/articles/s41388-018-0635-z

Death receptors

T cells genetically engineered to overcome death signaling enhance adoptive cancer immunotherapy – Tori N. Yamamoto, Ping-Hsien Lee, Suman K. Vodnala, Devikala Gurusamy, Rigel J. Kishton, Zhiya Yu, Arash Eidizadeh, Robert Eil, Jessica Fioravanti, Luca Gattinoni, James N. Kochenderfer, Terry J. Fry, Bulent Arman Aksoy, Jeffrey E. Hammerbacher, Anthony C. Cruz, Richard M. Siegel, Nicholas P. Restifo and Christopher A. Klebanoff. https://www.jci.org/articles/view/121491

Impact of p53 status on TRAIL-mediated apoptotic and non-apoptotic signaling in cancer cells – Anna Willms, Hella Schittek, Sascha Rahn, Justyna Sosna, Ufuk Mert, Dieter Adam, Anna Trauzold. https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0214847

Necroptosis, RIPK1

Direct Activation of Human MLKL by a Select Repertoire of Inositol Phosphate Metabolites – Dan E. McNamara, Cole M. Dovey, Andrew T. Hale, Giovanni Quarato, Christy R. Grace, Cristina D. Guibao, Jonathan Diep, Amanda Nourse, Casey R. Cai, Hong Wu, Ravi C. Kalathur, Douglas R. Green, John D. York, Jan E. Carette, Tudor Moldoveanu. https://www.cell.com/cell-chemical-biology/fulltext/S2451-9456(19)30106-0

Serine 25 phosphorylation inhibits RIPK1 kinase-dependent cell death in models of infection and inflammation – Yves Dondelinger, Tom Delanghe, Dario Priem, Meghan A. Wynosky-Dolfi, Daniel Sorobetea, Diego Rojas-Rivera, Piero Giansanti, Ria Roelandt, Julia Gropengiesser, Klaus Ruckdeschel, Savvas N. Savvides, Albert J. R. Heck, Peter Vandenabeele, Igor E. Brodsky and Mathieu J. M. Bertrand. https://www.nature.com/articles/s41467-019-09690-0

RIPK1 prevents TRADD-driven, but TNFR1 independent, apoptosis during development – Holly Anderton, Esther Bandala-Sanchez, Daniel S Simpson, James A Rickard, Ashley P Ng, Ladina Di Rago, Cathrine Hall, James E Vince, John Silke, Gianmaria Liccardi and Rebecca Feltham. https://www.nature.com/articles/s41418-018-0166-8


A GPX4-dependent cancer cell state underlies the clear-cell morphology and confers sensitivity to ferroptosis – Yilong Zou, Michael J. Palte, Amy A. Deik, Haoxin Li, John K. Eaton, Wenyu Wang, Yuen-Yi Tseng, Rebecca Deasy, Maria Kost-Alimova, Vlado Dančík, Elizaveta S. Leshchiner, Vasanthi S. Viswanathan, Sabina Signoretti, Toni K. Choueiri, Jesse S. Boehm, Bridget K. Wagner, John G. Doench, Clary B. Clish, Paul A. Clemons and Stuart L. Schreiber. https://www.nature.com/articles/s41467-019-09277-9

The Deubiquitylase OTUB1 Mediates Ferroptosis via Stabilization of SLC7A11 – Tong Liu, Le Jiang, Omid Tavana and Wei Gu. http://cancerres.aacrjournals.org/content/79/8/1913

Mechanistic basis for impaired ferroptosis in cells expressing the African-centric S47 variant of p53 – Julia I-Ju Leu, Maureen E. Murphy and Donna L. George. https://www.pnas.org/content/116/17/8390.abstract?etoc


Lysosomal Machinery Drives Extracellular Acidification to Direct Non-apoptotic Cell Death [of the nurse cell] – Albert A. Mondragon, Alla Yalonetskaya, Anthony J. Ortega, Yuanhang Zhang, Oandy Naranjo, Johnny Elguero, Won-Suk Chung, Kimberly McCall. https://www.cell.com/cell-reports/fulltext/S2211-1247(19)30350-X?


Methods for monitoring the progression of cell death, cell disassembly and cell clearance – Lanzhou Jiang and Ivan K. H. Poon. https://link.springer.com/article/10.1007/s10495-018-01511-x

Navigating the Fas lane to improved cellular therapy for cancer – Madhav V. Dhodapkar. https://www.jci.org/articles/view/127581

MAVS‐induced mitochondrial membrane remodeling – Hector Flores‐Romero, Ana J. García‐Sáez. https://febs.onlinelibrary.wiley.com/doi/10.1111/febs.14822

DUBbing Ferroptosis in Cancer Cells – Boyi Gan. http://cancerres.aacrjournals.org/content/79/8/1749


September 22-25, 2019, Weizmann Institute of Science


ApoList – March 2019

Caspases, metacaspases and IAPs

Apoptotic Caspases Suppress Type I Interferon Production via the Cleavage of cGAS, MAVS, and IRF3 – Xiaohan Ning, Yutao Wang, Miao Jing, Mengyin Sha, Mengze Lv, P engfei Gao, Rui Zhang, Xiaojun Huang, Ji-Ming Feng, Zhengfan Jiang. https://www.cell.com/molecular-cell/fulltext/S1097-2765(19)30103-0

Damage on plants activates Ca2+-dependent metacaspases for release of immunomodulatory peptides – Tim Hander, Álvaro D. Fernández-Fernández, Robert P. Kumpf, Patrick Willems, Hendrik Schatowitz, Debbie Rombaut, An Staes, Jonah Nolf, Robin Pottie, Panfeng Yao, Amanda Gonçalves, Benjamin Pavie, Thomas Boller, Kris Gevaert, Frank Van Breusegem, Sebastian Bartels, Simon Stael. http://science.sciencemag.org/content/363/6433/eaar7486

The Caspase-3 homolog DrICE regulates endocytic trafficking during Drosophila tracheal morphogenesis – Saoirse S. McSharry and Greg J. Beitel. https://www.nature.com/articles/s41467-019-09009-z

The RING domain in the anti-apoptotic protein XIAP stabilizes c-Myc protein and preserves anchorage-independent growth of bladder cancer cells – Guosong Jiang, Chao Huang, Xin Liao, Jingxia Li, Xue-Ru Wu, Fuqing Zeng and Chuanshu Huang. http://www.jbc.org/content/early/2019/02/28/jbc.RA118.005621.abstract

Necroptosis, RIP kinases

RIPK1 can mediate apoptosis in addition to necroptosis during embryonic development – Xuhua Zhang, John P. Dowling and Jianke Zhang. https://www.nature.com/articles/s41419-019-1490-8

Identification of a novel class of RIP1/RIP3 dual inhibitors that impede cell death and inflammation in mouse abdominal aortic aneurysm models – Ting Zhou, Qiwei Wang, Noel Phan, Jun Ren, Huan Yang, Conner C. Feldman, John B. Feltenberger, Zhengqing Ye, Scott A. Wildman, Weiping Tang and Bo Liu. https://www.nature.com/articles/s41419-019-1468-6

O-GlcNAc Transferase Suppresses Inflammation and Necroptosis by Targeting Receptor-Interacting Serine/Threonine-Protein Kinase 3 – Xinghui Li, Wei Gong, Hao Wang, Tianliang Li, Kuldeep S. Attri, Robert E. Lewis, Andre C. Kalil, Fatema Bhinderwala, Robert Powers, Guowei Yin, Laura E. Herring, John M. Asara, Yu L. Lei, Xiaoyong Yang, Diego A. Rodriguez, Mao Yang, Douglas R. Green, Pankaj K. Singh, Haitao Wen. https://www.cell.com/immunity/fulltext/S1074-7613(19)30030-5

RIP1 kinase inhibitor halts the progression of an immune-induced demyelination disease at the stage of monocyte elevation – Sitao Zhang, Yaning Su, Zhengxin Ying, Dejia Guo, Chenjie Pan, Jia Guo, Ziye Zou, Lei Wang, Ze Zhang, Zhaodi Jiang, Zhiyuan Zhang and Xiaodong Wang. https://www.pnas.org/content/116/12/5675.abstract?etoc

Activated MLKL attenuates autophagy following its translocation to intracellular membranes – Daniel Frank, David L. Vaux, James M. Murphy, James E. Vince and Lisa M. Lindqvist. http://jcs.biologists.org/content/132/5/jcs220996?etoc

Other non-apoptotic forms of cell death

Entosis Controls a Developmental Cell Clearance in C. elegans – Yongchan Lee, Jens C. Hamann, Mark Pellegrino, Joanne Durgan, Marie-Charlotte Domart, Lucy M. Collinson, Cole M. Haynes, Oliver Florey, Michael Overholtzer. https://www.cell.com/cell-reports/fulltext/S2211-1247(19)30252-9

Drosophila p53 directs non-apoptotic programs in postmitotic tissue – Paula Kurtz, Amanda E. Jones, Bhavana Tiwari, Nichole Link, Annika Wylie, Charles Tracy, Helmut Krämer and John M. Abrams. https://www.molbiolcell.org/doi/abs/10.1091/mbc.E18-12-0791

A major role for ferroptosis in Mycobacterium tuberculosis–induced cell death and tissue necrosis – Eduardo P. Amaral, Diego L. Costa, Sivaranjani Namasivayam, Nicolas Riteau, Olena Kamenyeva, Lara Mittereder, Katrin D. Mayer-Barber, Bruno B. Andrade and Alan Sher. http://jem.rupress.org/content/216/3/556?etoc

Efferocytosis and cell-cell communication

Apoptotic tumor cell-derived microRNA-375 uses CD36 to alter the tumor-associated macrophage phenotype – Ann-Christin Frank, Stefanie Ebersberger, Annika F. Fink, Sebastian Lampe, Andreas Weigert, Tobias Schmid, Ingo Ebersberger, Shahzad Nawaz Syed and Bernhard Brüne. https://www.nature.com/articles/s41467-019-08989-2

Bcl-2 family proteins

A Phase Ib Dose-Escalation and Expansion Study of the BCL2 Inhibitor Venetoclax Combined with Tamoxifen in ER and BCL2–Positive Metastatic Breast Cancer – Sheau W. Lok, James R. Whittle, François Vaillant, Charis E. Teh, Louisa L. Lo, Antonia N. Policheni, Alice R.T. Bergin, Jayesh Desai, Sarah Ftouni, Luke C. Gandolfo, Danny Liew, He K. Liu, G. Bruce Mann, Kate Moodie, Anand Murugasu, Bhupinder Pal, Andrew W. Roberts, Mark A. Rosenthal, Kylie Shackleton, Maria João Silva, Zhen R. Siow, Gordon K. Smyth, Leanne Taylor, Avraham Travers, Belinda Yeo, Miriam M. Yeung, Andjelija Zivanovic Bujak, Sarah-Jane Dawson, Daniel H.D. Gray, Jane E. Visvader and Geoffrey J. Lindeman. http://cancerdiscovery.aacrjournals.org/content/9/3/354

Bim escapes displacement by BH3-mimetic anti-cancer drugs by double-bolt locking both Bcl-XL and Bcl-2 – Qian Liu, Elizabeth J Oesterlund, Xiaoke Chi, Justin Pogmore, Brian Leber, David William Andrews. https://elifesciences.org/articles/37689

Acquisition of the Recurrent Gly101Val Mutation in BCL2 Confers Resistance to Venetoclax in Patients with Progressive Chronic Lymphocytic Leukemia – Piers Blombery, Mary Ann Anderson, Jia-nan Gong, Rachel Thijssen, Richard W. Birkinshaw, Ella R. Thompson, Charis E. Teh, Tamia Nguyen, Zhen Xu, Christoffer Flensburg, Thomas E. Lew, Ian J. Majewski, Daniel H.D. Gray, David A. Westerman, Constantine S. Tam, John F. Seymour, Peter E. Czabotar, David C.S. Huang and Andrew W. Roberts. http://cancerdiscovery.aacrjournals.org/content/9/3/342

The Ewing Family of Tumors Relies on BCL-2 and BCL-XL to Escape PARP Inhibitor Toxicity – Daniel A.R. Heisey, Timothy L. Lochmann, Konstantinos V. Floros, Colin M. Coon, Krista M. Powell, Sheeba Jacob, Marissa L. Calbert, Maninderjit S. Ghotra, Giovanna T. Stein, Yuki Kato Maves, Steven C. Smith, Cyril H. Benes, Joel D. Leverson, Andrew J. Souers, Sosipatros A. Boikos and Anthony C. Faber. http://clincancerres.aacrjournals.org/content/25/5/1664

Retromer facilitates the localization of Bcl-xL to the mitochondrial outer membrane – Trey Farmer, Katelyn L. O’Neill, Naava Naslavsky, Xu Luo and Steve Caplan. https://www.molbiolcell.org/doi/10.1091/mbc.E19-01-0044?ai=25zg&ui=2oy6&af=T

Mitochondrial origins of fractional control in regulated cell death – Luís C. Santos, Robert Vogel, Jerry E. Chipuk, Marc R. Birtwistle, Gustavo Stolovitzky and Pablo Meyer. https://www.nature.com/articles/s41467-019-09275-x


MDM2 Integrates Cellular Respiration and Apoptotic Signaling through NDUFS1 and the Mitochondrial Network – Rana Elkholi, Ioana Abraham-Enachescu, Andrew P. Trotta, Camila Rubio-Patiño, Jarvier N. Mohammed, Mark P.A. Luna-Vargas, Jesse D. Gelles, Joshua R. Kaminetsky, Madhavika N. Serasinghe, Cindy Zou, Sumaira Ali, Gavin P. McStay, Cathie M. Pfleger, Jerry Edward Chipuk. https://www.cell.com/molecular-cell/fulltext/S1097-2765(19)30102-9

Ran1 is essential for parental macronuclear import of apoptosis‐inducing factor and programmed nuclear death in Tetrahymena thermophila – Haixia Liang, Jing Xu, Wei Wang. https://febs.onlinelibrary.wiley.com/doi/10.1111/febs.14761


Autophagy-dependent cell death – Donna Denton and Sharad Kumar. https://www.nature.com/articles/s41418-018-0252-y

Intersections between Regulated Cell Death and Autophagy – Francesco Napoletano, Olga Baron, Peter Vandenabeele, Bertrand Mollereau, Manolis Fanto. https://www.cell.com/trends/cell-biology/fulltext/S0962-8924(18)30237-X

LC3-associated phagocytosis at a glance – Bradlee L. Heckmann and Douglas R. Green. http://jcs.biologists.org/content/132/5/jcs222984?etoc

Enzymatically oxidized phospholipids assume center stage as essential regulators of innate immunity and cell death – Valerie B. O’Donnell , Maceler Aldrovandi, Robert C. Murphy, Gerhard Krönke. http://stke.sciencemag.org/content/12/574/eaau2293

Oxidative stress, eryptosis and anemia: a pivotal mechanistic nexus in systemic diseases – Rosi Bissinger, Abdulla Al Mamun Bhuyan, Syed M. Qadri, Florian Lang. https://febs.onlinelibrary.wiley.com/doi/10.1111/febs.14606

Comments / other

Cheating Death: New Molecules Block BAX – Loren D. Walensky. https://www.cell.com/trends/molecular-medicine/fulltext/S1471-4914(19)30043-7

The good, the bad and the autophagosome: exploring unanswered questions of autophagy-dependent cell death – Jurgen Kriel and Ben Loos. https://www.nature.com/articles/s41418-018-0267-4

Interview: a conversation with Vishva M Dixit on his journey from remote African village to apoptosis, necroptosis and the inflammasome – Vishva M. Dixit. https://www.nature.com/articles/s41418-019-0294-9?

Gly101Val BCL2 Mutation: One Step Closer to Understanding Venetoclax Resistance in CLL – Shanmugapriya Thangavadivel and John C. Byrd. http://cancerdiscovery.aacrjournals.org/content/9/3/320

Targeting Apoptosis: A New Paradigm for the Treatment of Estrogen Receptor–Positive Breast Cancer – Joshua Z. Drago, Sarat Chandarlapaty and Komal Jhaveri. http://cancerdiscovery.aacrjournals.org/content/9/3/323


EMBO Workshop: Cell death in immunity and inflammation

06 – 09 October 2019 | Crete, Greece. Organized by Manolis Pasparakis and Núria Sánchez-Coll


ApoList – February 2019

Bcl-2 family proteins

Small-molecule allosteric inhibitors of BAX – Thomas P. Garner, Dulguun Amgalan, Denis E. Reyna, Sheng Li, Richard N. Kitsis & Evripidis Gavathiotis. https://www.nature.com/articles/s41589-018-0223-0

Molecular and topological reorganizations in mitochondrial architecture interplay during Bax-mediated steps of apoptosis – Nicholas R Ader, Patrick C Hoffmann, Iva Ganeva, Alicia C Borgeaud, Chunxin Wang, Richard J Youle, Wanda Kukulski. https://elifesciences.org/articles/40712

Constitutive IP3 signaling underlies the sensitivity of B-cell cancers to the Bcl-2/IP3 receptor disruptor BIRD-2 – Mart Bittremieux, Rita M. La Rovere, Haidar Akl, Claudio Martines, Kirsten Welkenhuyzen, Kathia Dubron, Myriam Baes, Ann Janssens, Peter Vandenberghe, Luca Laurenti, Katja Rietdorf, Giampaolo Morciano, Paolo Pinton, Katsuhiko Mikoshiba, Martin D. Bootman, Dimitar G. Efremov, Humbert De Smedt, Jan B. Parys and Geert Bultynck. https://www.nature.com/articles/s41418-018-0142-3

Confounding off-target effects of BH3 mimetics at commonly used concentrations: MIM1, UMI-77, and A-1210477 – David J. Mallick, Ryan S. Soderquist, Darcy Bates and Alan Eastman. https://www.nature.com/articles/s41419-019-1426-3

Biomarker-driven strategy for MCL1 inhibition in T-cell lymphomas – Raphael Koch, Amanda L. Christie, Jennifer L. Crombie, Adam C. Palmer, Deborah Plana, Kay Shigemori, Sara N. Morrow, Alexandria Van Scoyk, Wenchao Wu, Elizabeth A. Brem, J. Paul Secrist, Lisa Drew, Alwin G. Schuller, Justin Cidado, Anthony Letai and David M. Weinstock. http://bloodjournal.org/content/133/6/566.abstract

MGMT-activated DUB3 stabilizes MCL1 and drives chemoresistance in ovarian cancer – Xiaowei Wu, Qingyu Luo, Pengfei Zhao, Wan Chang, Yating Wang, Tong Shu, Fang Ding, Bin Li, and Zhihua Liu. https://www.pnas.org/content/116/8/2961.abstract

LncRNA H19 overexpression induces bortezomib resistance in multiple myeloma by targeting MCL-1 via miR-29b-3p – Yafang Pan, Yu Zhang, Wenwen Liu, Yan Huang, Xianjuan Shen, Rongrong Jing, Jiang Pu, Xudong Wang, Shaoqing Ju, Hui Cong and Hongmei Chen. https://www.nature.com/articles/s41419-018-1219-0

Folding/unfolding kinetics of G-quadruplexes upstream of the P1 promoter of the human BCL-2 oncogene – Yuanlei Cheng, Qingnan Tang, Yutong Li, Yashuo Zhang, Chuyuan Zhao, Jie Yan and Huijuan You. http://www.jbc.org/content/early/2019/02/20/jbc.RA119.007516.abstract

The pro-apoptotic Bcl-2 family member Harakiri (HRK) induces cell death in glioblastoma multiforme – Ezgi Kaya-Aksoy, Ahmet Cingoz, Filiz Senbabaoglu, Fidan Seker, Ilknur Sur-Erdem, Alisan Kayabolen, Tolga Lokumcu, Gizem Nur Sahin, Sercin Karahuseyinoglu and Tugba Bagci-Onder. https://www.nature.com/articles/s41420-019-0144-z

Death receptors, FADD

Redundant and receptor-specific activities of TRADD, RIPK1 and FADD in death receptor signaling – Simone Füllsack, Alevtina Rosenthal, Harald Wajant and Daniela Siegmund. https://www.nature.com/articles/s41419-019-1396-5

TRADD regulates perinatal development and adulthood survival in mice lacking RIPK1 and RIPK3 – John P. Dowling, Mohamed Alsabbagh, Christina Del Casale, Zheng-Gang Liu and Jianke Zhang. https://www.nature.com/articles/s41467-019-08584-5

Engagement of Fas differentially regulates the production of LPS‐induced proinflammatory cytokines and type I interferons – Kiva Brennan, Caitriona Lyons, Philana Fernandes, Sarah Doyle, Aileen Houston, Elizabeth Brint. https://febs.onlinelibrary.wiley.com/doi/10.1111/febs.14727

The classical NLRP3 inflammasome controls FADD unconventional secretion through microvesicle shedding – Sara Mouasni, Virginie Gonzalez, Alain Schmitt, Evangeline Bennana, François Guillonneau. https://www.nature.com/articles/s41419-019-1412-9

Death receptor 5 is activated by fucosylation in colon cancer cells – Baojie Zhang, Ingrid A. M. van Roosmalen, Carlos R. Reis, Rita Setroikromo, Wim J. Quax. https://febs.onlinelibrary.wiley.com/doi/10.1111/febs.14742

Generation and characterization of novel anti-DR4 and anti-DR5 antibodies developed by genetic immunization – Agathe Dubuisson, Cécile Favreau, Eric Fourmaux, Sabrina Lareure, Rafael Rodrigues-Saraiva, Catherine Pellat-Deceunynck, Said El Alaoui and Olivier Micheau. https://www.nature.com/articles/s41419-019-1343-5

Tumor necrosis factor‐related apoptosis‐inducing ligand reduces the expression of the neuroprotective Na+/Ca2+ exchanger isoform NCX3 in human neuroblastoma SH‐SY5Y cells – Giulia Di Benedetto, Oriana Valerio, Vincenzo Lariccia, Chiara Burgaletto, Laurence Lempereur, Carmela Parenti, Guido Nicola Zanghì, Alessandra Matteucci, Salvatore Amoroso, Renato Bernardini, Giuseppina Cantarella. https://febs.onlinelibrary.wiley.com/doi/10.1111/febs.14732

The regulatory protein GADD34 inhibits TRAIL-induced apoptosis via TRAF6/ERK-dependent stabilization of myeloid cell leukemia 1 in liver cancer cells – Peiying Song, Songpeng Yang, Hui Hua, Hongying Zhang, Qingbin Kong, Jiao Wang, Ting Luo and Yangfu Jiang. http://www.jbc.org/content/early/2019/02/19/jbc.RA118.006029.abstract

Insights into ligand binding by a viral tumor necrosis factor (TNF) decoy receptor yield a selective soluble human type 2 TNF receptor – Sergio M. Pontejo, Carolina Sanchez, Begoña Ruiz-Argüello and Antonio Alcami. http://www.jbc.org/content/early/2019/02/05/jbc.RA118.005828.abstract

Absence of Cytosolic 2-Cys Prx Subtypes I and II Exacerbates TNF-α-Induced Apoptosis via Different Routes – Sunmi Lee, Joo Young Lee, Eun Woo Lee, Sujin Park, Dong Hoon Kang, Chengchun Min, Doo Jae Lee, Dongmin Kang, Jaewhan Song, Jongbum Kwon, Sang Won Kang. https://www.cell.com/cell-reports/fulltext/S2211-1247(19)30110-X

Disruption of the FasL/Fas axis protects against inflammation-derived tumorigenesis in chronic liver disease – Francisco Javier Cubero, Marius Maximilian Woitok, Miguel E. Zoubek, Alain de Bruin, Maximilian Hatting and Christian Trautwein. https://www.nature.com/articles/s41419-019-1391-x

Caspases and IAPs

RIPK1 and Caspase-8 Ensure Chromosome Stability Independently of Their Role in Cell Death and Inflammation – Gianmaria Liccardi, Laura Ramos Garcia, Tencho Tenev, Alessandro Annibaldi, Arnaud J. Legrand, David Robertson, Rebecca Feltham, Holly Anderton, Maurice Darding, Nieves Peltzer, Marius Dannappel, Hannah Schünke, Luca L. Fava, Manuel D. Haschka, Timo Glatter, Alexey Nesvizhskii, Alexander Schmidt, Philip A. Harris, John Bertin, Peter J. Gough, Andreas Villunger, John Silke, Manolis Pasparakis, Katiuscia Bianchi, Pascal Meier. https://www.cell.com/molecular-cell/fulltext/S1097-2765(18)30980-8

SERPINB1-mediated checkpoint of inflammatory caspase activation – Youn Jung Choi, Stephanie Kim, Younho Choi, Travis B. Nielsen, Jun Yan, Alvin Lu, Jianbin Ruan, Hye-Ra Lee, Hao Wu, Brad Spellberg and Jae U. Jung. https://www.nature.com/articles/s41590-018-0303-z

XIAP facilitates breast and colon carcinoma growth via promotion of p62 depletion through ubiquitination-dependent proteasomal degradation – Xing Huang, Xiao-nan Wang, Xiao-dong Yuan, Wen-yong Wu, Peter E. Lobie and Zhengsheng Wu. https://www.nature.com/articles/s41388-018-0513-8

Smac mimetic suppresses tunicamycin-induced apoptosis via resolution of ER stress – Behnaz Ahangarian Abhari, Nicole McCarthy, Marie Le Berre, Michelle Kilcoyne, Lokesh Joshi. https://www.nature.com/articles/s41419-019-1381-z

Necroptosis / ferroptosis

DNase II activated by the mitochondrial apoptotic pathway regulates RIP1-dependent non-apoptotic hepatocyte death via the TLR9/IFN-β signaling pathway – Yoshinobu Saito, Hayato Hikita, Yasutoshi Nozaki, Yugo Kai, Yuki Makino, Tasuku Nakabori, Satoshi Tanaka, Ryoko Yamada, Minoru Shigekawa, Takahiro Kodama, Ryotaro Sakamori, Tomohide Tatsumi and Tetsuo Takehara. https://www.nature.com/articles/s41418-018-0131-6

Necroptosis directly induces the release of full‐length biologically active IL‐33 in vitroand in an inflammatory disease model – Inbar Shlomovitz, Ziv Erlich, Mary Speir, Sefi Zargarian, Noam Baram, Maya Engler, Liat Edry‐Botzer, Ariel Munitz, Ben A. Croker, Motti Gerlic. https://febs.onlinelibrary.wiley.com/doi/10.1111/febs.14738

Chaperone-mediated autophagy is involved in the execution of ferroptosis – Zheming Wu, Yang Geng, Xiaojuan Lu, Yuying Shi, Guowei Wu, Mengmeng Zhang, Bing Shan, Heling Pan and Junying Yuan. https://www.pnas.org/content/116/8/2996.abstract

A Genome-wide Haploid Genetic Screen Identifies Regulators of Glutathione Abundance and Ferroptosis Sensitivity – Jennifer Yinuo Cao, Aunoy Poddar, Leslie Magtanong, Jennifer H. Lumb, Trevor R. Mileur, Michael A. Reid, Cole M. Dovey, Jin Wang, Jason W. Locasale, Everett Stone, Susan P.C. Cole, Jan E. Carette, Scott J. Dixon. https://www.cell.com/cell-reports/fulltext/S2211-1247(19)30061-0

Necroptosis in primate luteolysis: a role for ceramide – Konstantin Bagnjuk, Jan Bernd Stöckl, Thomas Fröhlich, Georg Josef Arnold, Rüdiger Behr, Dieter Berg, Lars Kunz, Cecily Bishop, Jing Xu and Artur Mayerhofer. https://www.nature.com/articles/s41420-019-0149-7

Ferroptosis as a target for protection against cardiomyopathy – Xuexian Fang, Hao Wang, Dan Han, Enjun Xie, Xiang Yang, Jiayu Wei, Shanshan Gu, Feng Gao, Nali Zhu, Xiangju Yin, Qi Cheng, Pan Zhang, Wei Dai, Jinghai Chen, Fuquan Yang, Huang-Tian Yang, Andreas Linkermann, Wei Gu, Junxia Min and Fudi Wang. https://www.pnas.org/content/116/7/2672.abstract?etoc


Dying Neurons Utilize Innate Immune Signaling to Prime Glia for Phagocytosis during Development – Colleen N. McLaughlin, Jahci J. Perry-Richardson, Jaeda C. Coutinho-Budd, Heather T. Broihier. https://www.cell.com/developmental-cell/fulltext/S1534-5807(18)31087-6

Three cell deaths and a funeral: macrophage clearance of cells undergoing distinct modes of cell death – Katharina Klöditz and Bengt Fadeel. https://www.nature.com/articles/s41420-019-0146-x

Calpain cleaves phospholipid flippase ATP8A1 during apoptosis inplatelets – Weidong Jing, Mehmet Yabas, Angelika Bröer, Lucy Coupland, Elizabeth E.Gardiner, Anselm Enders and Stefan Bröer. http://www.bloodadvances.org/content/3/3/219.abstract?etoc


Mechanisms of cell death induced by arginase and asparaginase in precursor B-cell lymphoblasts – Lucy E. Métayer, Richard D. Brown, Saskia Carlebur, G. A. Amos Burke and Guy C. Brown. https://link.springer.com/article/10.1007/s10495-018-1506-3

Increased mitochondrial respiration promotes survival from endoplasmic reticulum stress – Jeffrey Knupp, Peter Arvan and Amy Chang. https://www.nature.com/articles/s41418-018-0133-4


To the edge of cell death and back – Yi‐Nan Gong, Jeremy Chase Crawford, Bradlee L. Heckmann, Douglas R. Green. https://febs.onlinelibrary.wiley.com/doi/10.1111/febs.14714

BCL-2 family isoforms in apoptosis and cancer – Chloe F. A. Warren, Michelle W. Wong-Brown and Nikola A. Bowden. https://www.nature.com/articles/s41419-019-1407-6

Targeting intrinsic cell death pathways to control fungal pathogens – Author links open overlay panelMadhuraKulkarni, Zachary D.Stolp, J. MarieHardwick. https://www.sciencedirect.com/science/article/abs/pii/S0006295219300188

Cancer therapeutics based on BCL-2 functional conversion – Martin C. Pearce, Arnold C. Satterthwait, Xiao-kun Zhang and Siva Kumar Kolluri. https://link.springer.com/article/10.1007/s10495-018-1504-5

TAK1 mediates convergence of cellular signals for death and survival – Sabreena Aashaq, Asiya Batool and Khurshid I. Andrabi. https://link.springer.com/article/10.1007/s10495-018-1490-7


Paradoxical Puma Prohibits Pyruvate Pumps to Prime Pathology – Douglas R. Green. https://www.cell.com/cancer-cell/fulltext/S1535-6108(19)30050-9

Death Eaters Rely on Metabolic Signaling to Wield Anti-inflammatory Responses – Antonietta Pietrangelo, Mireille Ouimet. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(19)30010-5

ApoList – January 2019


Bcl-2 family proteins

Wild-Type p53 Promotes Cancer Metabolic Switch by Inducing PUMA-Dependent Suppression of Oxidative Phosphorylation – Jinchul Kim, Lili Yu, Wancheng Chen, Yanxia Xu, Meng Wu, Dilyana Todorova, Qingshuang Tang, Bingbing Feng, Lei Jiang, Jingjin He, Guihua Chen, Xuemei Fu, Yang Xu. https://www.cell.com/cancer-cell/fulltext/S1535-6108(18)30584-1

Parkin inhibits BAK and BAX apoptotic function by distinct mechanisms during mitophagy – Jonathan P Bernardini, Jason M Brouwer, Iris KL Tan, Jarrod J Sandow, Shuai Huang, Che A Stafford, Aleksandra Bankovacki, Christopher D Riffkin, Ahmad Z Wardak, Peter E Czabotar, Michael Lazarou and Grant Dewson. http://EMBOJ.embopress.org/content/38/2/e99916?etoc

BFL1 modulates apoptosis at the membrane level through a bifunctional and multimodal mechanism showing key differences with BCLXL – Hector Flores-Romero, Olatz Landeta, Begoña Ugarte-Uribe, Katia Cosentino, Miguel García-Porras, Ana J. García-Sáez and Gorka Basañez. https://www.nature.com/articles/s41418-018-0258-5

Sensitivity to splicing modulation of BCL2 family genes defines cancer therapeutic strategies for splicing modulators – Daniel Aird, Teng Teng, Chia-Ling Huang, Ermira Pazolli, Deepti Banka, Kahlin Cheung-Ong, Cheryl Eifert, Craig Furman, Zhenhua Jeremy Wu, Michael Seiler, Silvia Buonamici, Peter Fekkes, Craig Karr, James Palacino, Eunice Park, Peter G. Smith, Lihua Yu, Yoshiharu Mizui, Markus Warmuth, Agustin Chicas, Laura Corson and Ping Zhu. https://www.nature.com/articles/s41467-018-08150-5

A Mammalian Mitophagy Receptor, Bcl2-L-13, Recruits the ULK1 Complex to Induce Mitophagy – Tomokazu Murakawa, Koji Okamoto, Shigemiki Omiya, Manabu Taneike, Osamu Yamaguchi, Kinya Otsu. https://www.cell.com/cell-reports/fulltext/S2211-1247(18)31980-6

Functional profiling of venetoclax sensitivity can predict clinical response in multiple myeloma – Shannon M. Matulis, Vikas A. Gupta,  Paola Neri, Nizar J. Bahlis, Paulo Maciag, Joel D. Leverson, Leonard T. Heffner Jr., Sagar Lonial, Ajay K. Nooka, Jonathan L. Kaufman and Lawrence H. Boise. https://www.nature.com/articles/s41375-018-0374-8

Death receptors

STAT3 inhibition induces Bax-dependent apoptosis in liver tumor myeloid-derived suppressor cells – Prajna Guha, Jillian Gardell, Josephine Darpolor, Marissa Cunetta, Matthew Lima, George Miller, N. Joseph Espat, Richard P. Junghans and Steven C. Katz. https://www.nature.com/articles/s41388-018-0449-z

TRAIL inhibits RANK signaling and suppresses osteoclast activation via inhibiting lipid raft assembly and TRAF6 recruitment – Hsiu-Jung Liao, Hwei-Fang Tsai, Chien-Sheng Wu, I.-Tsu Chyuan & Ping-Ning Hsu. https://www.nature.com/articles/s41419-019-1353-3

TAK1 Prevents Endothelial Apoptosis and Maintains Vascular Integrity – Hisamichi Naito, Tomohiro Iba, Taku Wakabayashi, Ikue Tai-Nagara, Jun-ichi Suehiro, Weizhen Jia, Daisuke Eino, Susumu Sakimoto, Fumitaka Muramatsu, Hiroyasu Kidoya, Hiroyuki Sakurai, Takashi Satoh, Shizuo Akira, Yoshiaki Kubota, Nobuyuki Takakura. https://www.cell.com/developmental-cell/fulltext/S1534-5807(18)31035-9

Caspases and IAPs

Caspase selective reagents for diagnosing apoptotic mechanisms – Marcin Poreba, Katarzyna Groborz, Mario Navarro, Scott J. Snipas, Marcin Drag and Guy S. Salvesen. https://www.nature.com/articles/s41418-018-0110-y

Transcriptome profiling of caspase-2deficient EμMyc and Th-MYCN mouse tumors identifies distinct putative roles for caspase-2 in neuronal differentiation and immune signaling – Loretta Dorstyn, Emily Hackett-Jones, Andrej Nikolic, Murray D. Norris, Yoon Lim, John Toubia, Michelle Haber and Sharad Kumar. https://www.nature.com/articles/s41419-018-1296-0

The prodomain of caspase-3 regulates its own removal and caspase activation – Katelyn G. Ponder and Lawrence H. Boise. https://www.nature.com/articles/s41420-019-0142-1

The transcription factor SP3 drives TNF-α expression in response to Smac mimetics – Shawn T. Beug , Herman H. Cheung, Tarun Sanda, Martine St-Jean, Caroline E. Beauregard, Hapsatou Mamady, Stephen D. Baird, Eric C. LaCasse, Robert G. Korneluk. http://stke.sciencemag.org/content/12/566/eaat9563

Necroptosis and RIP kinases

The Nucleotide Sensor ZBP1 and Kinase RIPK3 Induce the Enzyme IRG1 to Promote an Antiviral Metabolic State in Neurons – Brian P. Daniels, Sigal B. Kofman, Julian R. Smith, Geoffrey T. Norris, Annelise G. Snyder, Joseph P. Kolb, Xia Gao, Jason W. Locasale, Jennifer Martinez, Michael Gale Jr., Yueh-Ming Loo, Andrew Oberst. https://www.cell.com/immunity/fulltext/S1074-7613(18)30525-9

Increased Ripk1-mediated bone marrow necroptosis leads to myelodysplasia and bone marrow failure in mice – Patrice N. Wagner, Qiong Shi, Christi T. Salisbury-Ruf, Jing Zou, Michael R. Savona, Yuri Fedoriw and Sandra S. Zinkel. http://bloodjournal.org/content/133/2/107.abstract?etoc

Receptor-interacting Ser/Thr kinase 1 (RIPK1) and myosin IIA–dependent ceramidosomes form membrane pores that mediate blebbing and necroptosis – Rose Nganga, Natalia Oleinik, Jisun Kim, Shanmugam Panneer Selvam, Ryan De Palma, Kristen A. Johnson, Rasesh Y. Parikh, Vamsi Gangaraju, Yuri Peterson, Mohammed Dany, Robert V. Stahelin, Christina Voelkel-Johnson, Zdzislaw M. Szulc, Erhard Bieberich and Besim Ogretmen. http://www.jbc.org/content/294/2/502.abstract.html

Human RIPK1 deficiency causes combined immunodeficiency and inflammatory bowel diseases – Yue Li, Marita Führer, Ehsan Bahrami, Piotr Socha, Maja Klaudel-Dreszler, Amira Bouzidi, Yanshan Liu, Anna S. Lehle, Thomas Magg, Sebastian Hollizeck, Meino Rohlfs, Raffaele Conca, Michael Field, Neil Warner, Slae Mordechai, Eyal Shteyer, Dan Turner, Rachida Boukari, Reda Belbouab, Christoph Walz, Moritz M. Gaidt, Veit Hornung, Bernd Baumann, Ulrich Pannicke, Eman Al Idrissi, Hamza Ali Alghamdi, Fernando E. Sepulveda, Marine Gil, Geneviève de Saint Basile, Manfred Hönig, Sibylle Koletzko, Aleixo M. Muise, Scott B. Snapper, Klaus Schwarz, Christoph Klein and Daniel Kotlarz. https://www.pnas.org/content/116/3/970.abstract?etoc

Depletion of RIPK1 in hepatocytes exacerbates liver damage in fulminant viral hepatitis – Muhammad Farooq, Aveline Filliol, Mélanie Simoes Eugénio, Claire Piquet-Pellorce, Sarah Dion, Céline Raguenes-Nicol, Aurélien Jan, Marie-Thérèse Dimanche-Boitrel, Jacques Le Seyec and Michel Samson. https://www.nature.com/articles/s41419-018-1277-3

Constitutive interferon signaling maintains critical threshold of MLKL expression to license necroptosis – Joseph Sarhan, Beiyun C. Liu, Hayley I. Muendlein, Chi G. Weindel, Irina Smirnova, Amy Y. Tang, Vladimir Ilyukha, Maxim Sorokin, Anton Buzdin, Katherine A. Fitzgerald and Alexander Poltorak. https://www.nature.com/articles/s41418-018-0122-7

Autophagic cell death / Ferroptosis

Autophagic cell death restricts chromosomal instability during replicative crisis – Joe Nassour, Robert Radford, Adriana Correia. https://www.nature.com/articles/s41586-019-0885-0

Role of Mitochondria in Ferroptosis – Minghui Gao, Junmei Yi, Jiajun Zhu, Alexander M. Minikes, Prashant Monian, Craig B. Thompson, Xuejun Jiang. https://www.cell.com/molecular-cell/fulltext/S1097-2765(18)30936-5

Exogenous Monounsaturated Fatty Acids Promote a Ferroptosis-Resistant Cell State – Leslie Magtanong, Pin-Joe Ko, Milton To, Daniel K. Nomura, James A. Olzmann, Scott J. Dixon. https://www.cell.com/cell-chemical-biology/pdf/S2451-9456(18)30438-0.pdf


Identification of a novel anoikis signalling pathway using the fungal virulence factor gliotoxin – Haun F, Neumann S, Peintner L, Wieland K, Habicht J, Schwan C, Østevold K, Koczorowska MM, Biniossek M, Kist M, Busch H, Boerries M, Davis RJ, Maurer U, Schilling O, Aktories K, Borner C. https://www.nature.com/articles/s41467-018-05850-w


Regulation of apoptosis in health and disease: the balancing act of BCL-2 family proteins – Rumani Singh, Anthony Letai & Kristopher Sarosiek. https://www.nature.com/articles/s41580-018-0089-8

RIP Kinases in Liver Cell Death, Inflammation and Cancer – Vangelis Kondylis, Manolis Pasparakis. https://www.cell.com/trends/molecular-medicine/fulltext/S1471-4914(18)30203-X

BCL2-Family Dysregulation in B-Cell Malignancies: From Gene Expression Regulation to a Targeted Therapy Biomarker – Benoît Tessoulin, Antonin Papin, Patricia Gomez-Bougie, Celine Bellanger, Martine Amiot, Catherine Pellat-Deceunynck and David Chiron. https://www.frontiersin.org/articles/10.3389/fonc.2018.00645/full

Tissue-specific regulation of cytochrome c by post-translational modifications: respiration, the mitochondrial membrane potential, ROS, and apoptosis – Hasini A. Kalpage, Viktoriia Bazylianska, Maurice A. Recanati, Alemu Fite, Jenney Liu, Junmei Wan, Nikhil Mantena, Moh H. Malek, Izabela Podgorski, Elizabeth I. Heath, Asmita Vaishnav, Brian F. Edwards, Lawrence I. Grossman, Thomas H. Sanderson, Icksoo Lee and Maik Hüttemann. https://www.fasebj.org/doi/abs/10.1096/fj.201801417R?ai=s4&ui=ly8&af=T

Cell death pathways in pathogenic trypanosomatids: lessons of (over)kill – Rubem Figueiredo Sadok Menna-Barreto. https://www.nature.com/articles/s41419-019-1370-2


BH3 mimetics: Weapons of cancer cell destruction – Tríona Ní Chonghaile. http://stm.sciencemag.org/content/11/475/eaaw5311

Think We Understand the Role of DRP1 in Mitochondrial Biology? Zinc Again! – Jerry Edward Chipuk. https://www.cell.com/molecular-cell/fulltext/S1097-2765(18)31100-6

Endothelial Cell Killing by TAK1 Inhibition: A Novel Anti-angiogenic Strategy in Cancer Therapy – Nieves Peltzer, Henning Walczak. https://www.cell.com/developmental-cell/fulltext/S1534-5807(19)30011-5

BID-ding on necroptosis in MDS – Ben A. Croker and Michelle A. Kelliher. http://www.bloodjournal.org/content/133/2/103

RIPK3: Beyond Necroptosis – Azia S. Evans, Carolyn B. Coyne. https://www.cell.com/immunity/fulltext/S1074-7613(18)30579-X

Defying Death: The (W)hole Truth about the Fate of GSDMD Pores – Charles L. Evavold, Jonathan C. Kagan. https://www.cell.com/immunity/fulltext/S1074-7613(18)30580-6

Profile of Hao Wu – Farooq Ahmed. https://www.pnas.org/content/116/4/1078?etoc=

Retrospective. Gordon Shore (1945 – 2018).http://www.asbmb.org/asbmbtoday/201901/Retrospective/Shore/#disqus_thread

Upcoming meetings

Genes and Cancer 2019 / 8 – 11 April 2019. Cambridge, UK,


2nd Cell Death, Cell Stress and Metabolism Conference / 27 May 2019 – 30 May 2019. Puerto Vallarta, México


Cold Spring Harbor Cell Death meeting / August 13 – 17, 2019


ApoList – December 2018


Multidomain Bcl-2 family proteins

Discovery of Mcl-1-specific inhibitor AZD5991 and preclinical activity in multiple myeloma and acute myeloid leukemia – Adriana E. Tron, Matthew A. Belmonte, Ammar Adam, Brian M. Aquila, Lawrence H. Boise, Elisabetta Chiarparin, Justin Cidado, Kevin J. Embrey, Eric Gangl, Francis D. Gibbons, Gareth P. Gregory, David Hargreaves, J. Adam Hendricks, Jeffrey W. Johannes, Ricky W. Johnstone, Steven L. Kazmirski, Jason G. Kettle, Michelle L. Lamb, Shannon M. Matulis, Ajay K. Nooka, Martin J. Packer, Bo Peng, Philip B. Rawlins, Daniel W. Robbins, Alwin G. Schuller, Nancy Su, Wenzhan Yang, Qing Ye, Xiaolan Zheng, J. Paul Secrist, Edwin A. Clark, David M. Wilson, Stephen E. Fawell and Alexander W. Hird. https://www.nature.com/articles/s41467-018-07551-w

Venetoclax combined with decitabine or azacitidine in treatment-naive, elderly patients with acute myeloid leukemia – Courtney D. DiNardo, Keith Pratz, Vinod Pullarkat, Brian A. Jonas, Martha Arellano, Pamela S. Becker, Olga Frankfurt, Marina Konopleva, Andrew H. Wei, Hagop M. Kantarjian, Tu Xu, Wan-Jen Hong, Brenda Chyla, Jalaja Potluri, Daniel A. Pollyea and Anthony Letai. http://bloodjournal.org/content/133/1/7.abstract?etoc

BH3-mimetic toolkit guides the respective use of BCL2 and MCL1 BH3-mimetics in myeloma treatment – Patricia Gomez-Bougie, Sophie Maiga, Benoît Tessoulin, Jessie Bourcier, Antoine Bonnet, Manuel S. Rodriguez, Steven Le Gouill, Cyrille Touzeau, Philippe Moreau, Catherine Pellat-Deceunynck and Martine Amiot. http://bloodjournal.org/content/132/25/2656.abstract?etoc

Genetic biomarkers predict response to dual BCL-2 and MCL-1 targeting in acute myeloid leukaemia cells – Martin Grundy, Sahana Balakrishnan, Matthew Fox, Claire H. Seedhouse and  Nigel H. Russell. http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=view&path[]=26540&path[]=82570

Variable BCL2/BCL2L1 ratio in multiple myeloma with t(11;14) – Alice Cleynen, Mehmet Samur, Aurore Perrot, Laure Buisson, Sabrina Maheo, Mariateresa Fulciniti, Michel Attal, Nikhil Munshi, Hervé Avet-Loiseau and Jill Corre. http://bloodjournal.org/content/132/26/2778?etoc

Targeting BCL-xL improves the efficacy of bromodomain and extra-terminal protein inhibitors in triple-negative breast cancer by eliciting the death of senescent cells – Sylvia S. Gayle, Jennifer M. Sahni, Bryan M. Webb, Kristen L. Weber-Bonk, Melyssa S. Shively, Raffaella Spina, Eli E. Bar, Matthew K. Summers and Ruth A. Keri. http://www.jbc.org/content/early/2018/11/27/jbc.RA118.004712.abstract

HOXC6 promotes cervical cancer progression via regulation of Bcl-2 – Yongsheng Wang, Cong Wang, Na Liu, Jun Hou, Wenjing Xiao and Hui Wang. https://www.fasebj.org/doi/abs/10.1096/fj.201801099RR?ai=ts&ui=ly8&af=T

NOTCH1 Represses MCL-1 Levels in GSI-resistant T-ALL, Making them Susceptible to ABT-263 – Anahita Dastur, AHyun Choi, Carlotta Costa, Xunqin Yin, August Williams, Joseph McClanaghan, Max Greenberg, Justine Roderick, Neha U. Patel, Jessica Boisvert, Ultan McDermott, Mathew J. Garnett, Jorge Almenara, Steven Grant, Kathryn Rizzo, Jeffrey A. Engelman, Michelle Kelliher, Anthony C. Faber and Cyril H. Benes. http://clincancerres.aacrjournals.org/content/25/1/31

Targeted inhibition of PI3Kα/δ is synergistic with BCL-2 blockade in genetically defined subtypes of DLBCL – Kamil Bojarczuk, Kirsty Wienand, Jeremy A. Ryan, Linfeng Chen, Mariana Villalobos-Ortiz, Elisa Mandato, Joanna Stachura, Anthony Letai, Lee N. Lawton, Bjoern Chapuy and Margaret A. Shipp. http://bloodjournal.org/content/133/1/70.abstract?etoc

BH3-only proteins

Spatiotemporal Control of CNS Myelination by Oligodendrocyte Programmed Cell Death through the TFEB-PUMA Axis – Lu O. Sun, Sara B. Mulinyawe, Hannah Y. Collins, Adiljan Ibrahim, Qingyun Li, David J. Simon, Marc Tessier-Lavigne, Ben A. Barres. https://www.cell.com/cell/fulltext/S0092-8674(18)31400-4?dgcid=raven_jbs_etoc_email

Lymphocyte-Specific Chromatin Accessibility Pre-determines Glucocorticoid Resistance in Acute Lymphoblastic Leukemia [Bim] – Duohui Jing, Yizhou Huang, Xiaoyun Liu, Keith C.S. Sia, Julia C. Zhang, Xiaolu Tai, Meng Wang, Cara E. Toscan, Hannah McCalmont, Kathryn Evans, Chelsea Mayoh, Rebecca C. Poulos, Miriam Span, Jianqing Mi, Chao Zhang, Jason W.H. Wong, Dominik Beck, John E. Pimanda, Richard B. Lock. https://www.cell.com/cancer-cell/fulltext/S1535-6108(18)30523-3

Mouse ER+/PIK3CAH1047R breast cancers caused by exogenous estrogen are heterogeneously dependent on estrogen and undergo BIM-dependent apoptosis with BH3 and PI3K agents – Elias E. Stratikopoulos, Nicole Kiess, Matthias Szabolcs, Sarah Pegno, Cheung Kakit, Xuewei Wu, Poulikos I. Poulikakos, Pamela Cheung, Hank Schmidt and Ramon Parsons. https://www.nature.com/articles/s41388-018-0436-4?

Death receptors

Herpes simplex virus 1 ICP6 impedes TNF receptor 1-induced necrosome assembly during compartmentalization to detergent-resistant membrane vesicles – Mohammad Ali, Linda Roback and Edward S. Mocarski. http://www.jbc.org/content/early/2018/11/30/jbc.RA118.004651.abstract

Caspase-8 and FLIP

RIPK1 and Caspase-8 Ensure Chromosome Stability Independently of Their Role in Cell Death and Inflammation – Gianmaria Liccardi, Laura Ramos Garcia, Tencho Tenev, Alessandro Annibaldi, Arnaud J. Legrand, David Robertson, Rebecca Feltham, Holly Anderton, Maurice Darding, Nieves Peltzer, Marius Dannappel, Hannah Schünke, Luca L. Fava, Manuel D. Haschka, Timo Glatter, Alexey Nesvizhskii, Alexander Schmidt, Philip A. Harris, John Bertin, Peter J. Gough, Andreas Villunger, John Silke, Manolis Pasparakis, Katiuscia Bianchi, Pascal Meier. https://www.cell.com/molecular-cell/fulltext/S1097-2765(18)30980-8

Regulated proteolysis of p62/SQSTM1 enables differential control of autophagy and nutrient sensing – Julia Sanchez-Garrido, Vanessa Sancho-Shimizu and Avinash R. Shenoy. http://stke.sciencemag.org/content/11/559/eaat6903

TLR-stimulated IRAKM activates caspase-8 inflammasome in microglia and promotes neuroinflammation – Cun-Jin Zhang, Meiling Jiang, Hao Zhou, Weiwei Liu, Chenhui Wang, Zizhen Kang, Bing Han, Quanri Zhang, Xing Chen, Jianxin Xiao, Amanda Fisher, William J. Kaiser, Masanori A. Murayama, Yoichiro Iwakura, Ji Gao, Julie Carman, Ashok Dongre, George Dubyak, Derek W. Abbott, Fu-Dong Shi, Richard M. Ransohoff and Xiaoxia Li. https://www.jci.org/articles/view/121901

Induction of immunosuppressive functions and NF-κB by FLIP in monocytes – Alessandra Fiore, Stefano Ugel, Francesco De Sanctis, Sara Sandri, Giulio Fracasso, Rosalinda Trovato, Silvia Sartoris, Samantha Solito, Susanna Mandruzzato, Fulvia Vascotto, Keli L. Hippen, Giada Mondanelli, Ursula Grohmann, Geny Piro, Carmine Carbone, Davide Melisi, Rita T. Lawlor, Aldo Scarpa, Alessia Lamolinara, Manuela Iezzi, Matteo Fassan, Silvio Bicciato, Bruce R. Blazar, Ugur Sahin, Peter J. Murray and Vincenzo Bronte. https://www.nature.com/articles/s41467-018-07654-4


Single-cell analysis of pyroptosis dynamics reveals conserved GSDMD-mediated subcellular events that precede plasma membrane rupture – Nathalia M. de Vasconcelos, Nina Van Opdenbosch, Hanne Van Gorp, Eef Parthoens and Mohamed Lamkanfi. https://www.nature.com/articles/s41418-018-0106-7

Inflammation / Efferocytosis

Molecular mechanisms of biogenesis of apoptotic exosome-like vesicles and their roles as damage-associated molecular patterns – Soo Jeong Park, Jeong Mi Kim, Jihyo Kim, Jaehark Hur, Sun Park, Kyongmin Kim, Ho-Joon Shin and Yong-Joon Chwae. https://www.pnas.org/content/115/50/E11721?etoc=

Efferocytosis Fuels Requirements of Fatty Acid Oxidation and the Electron Transport Chain to Polarize Macrophages for Tissue Repair – Shuang Zhang, Samuel Weinberg, Matthew DeBerge, Anastasiia Gainullina, Matthew Schipma, Jason M. Kinchen, Issam Ben-Sahra, David R. Gius, Laurent Yvan- Charvet, Navdeep S. Chandel, Paul T. Schumacker, Edward B. Thorp. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(18)30741-1#%20

Treatment-Induced Tumor Cell Apoptosis and Secondary Necrosis Drive Tumor Progression in the Residual Tumor Microenvironment through MerTK and IDO1 – Thomas A. Werfel, David L. Elion, Bushra Rahman, Donna J. Hicks, Violeta Sanchez, Paula I. Gonzales-Ericsson, Mellissa J. Nixon, Jamaal L. James, Justin M. Balko, Peggy A. Scherle, Holly K. Koblish and Rebecca S. Cook. http://cancerres.aacrjournals.org/content/79/1/171


The SMAC mimetic LCL-161 displays antitumor activity in preclinical models of rituximab-resistant B-cell lymphoma – Kyle Runckel, Matthew J. Barth, Cory Mavis, Juan J. Gu and Francisco J. Hernandez-Ilizaliturri. http://www.bloodadvances.org/content/2/23/3516.abstract?etoc

Dimerization and auto-processing induce caspase-11 protease activation within the non-canonical inflammasome – Connie Ross, Amy H Chan, Jessica Von Pein, Dave Boucher and Kate Schroder. http://life-science-alliance.org/content/1/6/e201800237.abstract

ATP Synthase C-Subunit-Deficient Mitochondria Have a Small Cyclosporine A-Sensitive Channel, but Lack the Permeability Transition Pore – Maria A. Neginskaya, Maria E. Solesio, Elena V. Berezhnaya, Giuseppe F. Amodeo, Nelli Mnatsakanyan, Elizabeth A. Jonas, Evgeny V. Pavlov. https://www.cell.com/cell-reports/fulltext/S2211-1247(18)31963-6


BH3-Mimetic Drugs: Blazing the Trail for New Cancer Medicines – Delphine Merino, Gemma L. Kelly, Guillaume Lessene, Andrew H. Wei, Andrew W. Roberts, Andreas Strasser. https://www.cell.com/cancer-cell/fulltext/S1535-6108(18)30525-7

The Structural Basis of Necroptotic Cell Death Signaling – Emma J. Petrie, Peter E. Czabotar, James M. Murphy. https://www.cell.com/trends/biochemical-sciences/fulltext/S0968-0004(18)30229-9

Role and Regulation of Pro-survival BCL-2 Proteins in Multiple Myeloma – Anne Slomp and Victor Peperzak. https://www.frontiersin.org/articles/10.3389/fonc.2018.00533/full


Special issue on Necroinflammation



* Death and fire: the concept of necroinflammation – Andreas Linkermann

* Necroptosis in anti-viral inflammation – Himani Nailwal and Francis Ka-Ming Chan

* Ferroptosis and necroinflammation, a yet poorly explored link – Bettina Proneth and Marcus Conrad

* Programmed Necrosis and Disease:We interrupt your regular programming to bring you necroinflammation – Eui Ho Kim, Sing-Wai Wong and Jennifer Martinez

* Crashing the computer: apoptosis vs. necroptosis in neuroinflammation – Bradlee L. Heckmann, Bart Tummers and Douglas R. Green

* Necroinflammation emerges as a key regulator of hematopoiesis in health and disease – Philipp J. Jost and Ulrike Höckendorf

* Paving the way for precision medicine v2.0 in intensive care by profiling necroinflammation in biofluids – Tom Vanden Berghe and Eric Hoste

* Pyroptosis versus necroptosis: similarities, differences, and crosstalk – Daniel Frank and James E. Vince

* Comparing the effects of different cell death programs in tumor progression and immunotherapy – Michelle N. Messmer, Annelise G. Snyder and Andrew Oberst


Macrophages regulate the clearance of living cells by calreticulin – Dmitri V. Krysko, Kodi S. Ravichandran and Peter Vandenabeele. https://www.nature.com/articles/s41467-018-06807-9

Glucocorticoid Resistance in Acute Lymphoblastic Leukemia: BIM Finally – Jessie A. Brown, Adolfo Ferrando. https://www.cell.com/cancer-cell/fulltext/S1535-6108(18)30532-4

Venetoclax in AML: aiming for “just right” – Laura C. Michaelis. http://bloodjournal.org/content/133/1/3?etoc

ApoList – November 2018


Efferocytosis / Inflammation

The Mitochondrial Apoptotic Effectors BAX/BAK Activate Caspase-3 and -7 to Trigger NLRP3 Inflammasome and Caspase-8 Driven IL-1β Activation – James E. Vince, Dominic De Nardo, Wenqing Gao, Angelina J. Vince, Cathrine Hall, Kate McArthur, Daniel Simpson, Swarna Vijayaraj, Lisa M. Lindqvist, Philippe Bouillet, Mark A. Rizzacasa, Si Ming Man, John Silke, Seth L. Masters, Guillaume Lessene, David C.S. Huang, Daniel H.D. Gray, Benjamin T. Kile, Feng Shao, Kate E. Lawlor. https://www.cell.com/cell-reports/fulltext/S2211-1247(18)31725-X

BAX/BAK-Induced Apoptosis Results in Caspase-8-Dependent IL-1β Maturation in Macrophages – Dhruv Chauhan, Eva Bartok, Moritz M. Gaidt, Florian J. Bock, Jennifer Herrmann, Jens M. Seeger, Petr Broz, Roland Beckmann, Hamid Kashkar, Stephen W.G. Tait, Rolf Müller, Veit Hornung. https://www.cell.com/cell-reports/fulltext/S2211-1247(18)31691-7

Efferocytosis induces a novel SLC program to promote glucose uptake and lactate release – Sho Morioka, Justin S. A. Perry, Michael H. Raymond, Christopher B. Medina, Yunlu Zhu, Liyang Zhao, Vlad Serbulea, Suna Onengut-Gumuscu, Norbert Leitinger, Sarah Kucenas, Jeffrey C. Rathmell, Liza Makowski and Kodi S. Ravichandran. https://www.nature.com/articles/s41586-018-0735-5

Efferocytosis of apoptotic alveolar epithelial cells is sufficient to initiate lung fibrosis – Kevin K. Kim, Megan R. Dotson, Manisha Agarwal, Jibing Yang, Patrick B. Bradley, Natalia Subbotina, John J. Osterholzer and Thomas H. Sisson. https://www.nature.com/articles/s41419-018-1074-z

Pyroptosis / Gasdermin D / Gasdermin E

Caspase-8 induces cleavage of gasdermin D to elicit pyroptosis during Yersinia infection – Joseph Sarhan, Beiyun C. Liu, Hayley I. Muendlein, Peng Li, Rachael Nilson, Amy Y. Tang, Anthony Rongvaux, Stephen C. Bunnell, Feng Shao, Douglas R. Green, and Alexander Poltorak. http://www.pnas.org/content/115/46/E10888?etoc=

Pathogen blockade of TAK1 triggers caspase-8–dependent cleavage of gasdermin D and cell death – Pontus Orning, Dan Weng, Kristian Starheim, Dmitry Ratner, Zachary Best, Bettina Lee, Alexandria Brooks, Shiyu Xia, Hao Wu, Michelle A. Kelliher, Scott B. Berger, Peter J. Gough, John Bertin, Megan M. Proulx, Jon D. Goguen, Nobuhiko Kayagaki, Katherine A. Fitzgerald, Egil Lien. http://science.sciencemag.org/content/362/6418/1064

ESCRT-dependent membrane repair negatively regulates pyroptosis downstream of GSDMD activation – Sebastian Rühl, Kateryna Shkarina, Benjamin Demarco, Rosalie Heilig, José Carlos Santos, Petr Broz. http://science.sciencemag.org/content/362/6417/956

Shiga Toxin/Lipopolysaccharide Activates Caspase-4 and Gasdermin D to Trigger Mitochondrial Reactive Oxygen Species Upstream of the NLRP3 Inflammasome – Jaye M. Platnich, Hyunjae Chung, Arthur Lau, Christina F. Sandall, Adom Bondzi-Simpson, Huey-Miin Chen, Takanori Komada, Aaron C. Trotman-Grant, Jeremy R. Brandelli, Justin Chun, Paul L. Beck, Dana J. Philpott, Stephen E. Girardin, May Ho, Roger P. Johnson, Justin A. MacDonald, Glen D. Armstrong, Daniel A. Muruve. https://www.cell.com/cell-reports/fulltext/S2211-1247(18)31531-6

Molecular Targeted Therapies Elicit Concurrent Apoptotic and GSDME-Dependent Pyroptotic Tumor Cell Death – Haijiao Lu, Shengzhe Zhang, Jie Wu, Minjiang Chen, Mei-Chun Cai, Yujie Fu, Wenfeng Li, Jing Wang, Xiaojing Zhao, Zhuang Yu, Pengfei Ma and Guanglei Zhuang. http://clincancerres.aacrjournals.org/content/24/23/6066

Gasdermin E Does Not Limit Apoptotic Cell Disassembly by Promoting Early Onset of Secondary Necrosis in Jurkat T Cells and THP-1 Monocytes – Rochelle Tixeira, Bo Shi†, Michael A. F. Parkes, Amy L. Hodge, Sarah Caruso, Mark D. Hulett, Amy A. Baxter, Thanh Kha Phan and Ivan K. H. Poon. https://www.frontiersin.org/articles/10.3389/fimmu.2018.02842/full

Death receptors / FLIP

TBK1 and IKKε prevent TNF-induced cell death by RIPK1 phosphorylation – Elodie Lafont, Peter Draber, Eva Rieser, Matthias Reichert, Sebastian Kupka, Diego de Miguel, Helena Draberova, Anne von Mässenhausen, Amandeep Bhamra, Stephen Henderson, Katarzyna Wojdyla, Avigayil Chalk, Silvia Surinova, Andreas Linkermann and Henning Walczak. https://www.nature.com/articles/s41556-018-0229-6

Fas receptor induces apoptosis of synovial bone and cartilage progenitor populations and promotes bone loss in antigen-induced arthritis – Elvira Lazić Mosler, Nina Lukač, Darja Flegar, Martina Fadljević, Igor Radanović, Hrvoje Cvija, Tomislav Kelava, Sanja Ivčević, Alan Šućur, Antonio Markotić, Vedran Katavić, Ana Marušić, Danka Grčević and Nataša Kovačić. https://www.fasebj.org/doi/abs/10.1096/fj.201801426R?ai=ts&ui=ly8&af=T

Cell polarity and adherens junction formation inhibit epithelial Fas cell death receptor signaling – Laurent Gagnoux-Palacios, Hala Awina, Stéphane Audebert, Aurélie Rossin, Magali Mondin, Franck Borgese, Carlota Planas-Botey, Amel Mettouchi, Jean-Paul Borg and Anne-Odile Hueber. http://jcb.rupress.org/content/217/11/3839?etoc

Cytoplasmic FLIP(S) and nuclear FLIP(L) mediate resistance of castrate-resistant prostate cancer to apoptosis induced by IAP antagonists – Christopher McCann, Nyree Crawford, Joanna Majkut, Caitriona Holohan, Chris W. D. Armstrong, Pamela J. Maxwell, Chee Wee Ong, Melissa J. LaBonte, Simon S. McDade, David J. Waugh and Daniel B. Longley. https://www.nature.com/articles/s41419-018-1125-5


A Novel MCL1 Inhibitor Combined with Venetoclax Rescues Venetoclax-Resistant Acute Myelogenous Leukemia – Haley E. Ramsey, Melissa A. Fischer, Taekyu Lee, Agnieszka E. Gorska, Maria Pia Arrate, Londa Fuller, Kelli L. Boyd, Stephen A. Strickland, John Sensintaffar, Leah J. Hogdal, Gregory D. Ayers, Edward T. Olejniczak, Stephen W. Fesik and Michael R. Savona. http://cancerdiscovery.aacrjournals.org/content/8/12/1566

AMG 176, a Selective MCL1 Inhibitor, Is Effective in Hematologic Cancer Models Alone and in Combination with Established Therapies – Sean Caenepeel, Sean P. Brown, Brian Belmontes, Gordon Moody, Kathleen S. Keegan, Danny Chui, Douglas A. Whittington, Xin Huang, Leszek Poppe, Alan C. Cheng, Mario Cardozo, Jonathan Houze, Yunxiao Li, Brian Lucas, Nick A. Paras, Xianghong Wang, Joshua P. Taygerly, Marc Vimolratana, Manuel Zancanella, Liusheng Zhu, Elaina Cajulis, Tao Osgood, Jan Sun, Leah Damon, Regina K. Egan, Patricia Greninger, Joseph D. McClanaghan, Jianan Gong, Donia Moujalled, Giovanna Pomilio, Pedro Beltran, Cyril H. Benes, Andrew W. Roberts, David C. Huang, Andrew Wei, Jude Canon, Angela Coxon and Paul E. Hughes. http://cancerdiscovery.aacrjournals.org/content/8/12/1582

Exploiting MCL1 Dependency with Combination MEK + MCL1 Inhibitors Leads to Induction of Apoptosis and Tumor Regression in KRAS-Mutant Non–Small Cell Lung Cancer – Varuna Nangia, Faria M. Siddiqui, Sean Caenepeel, Daria Timonina, Samantha J. Bilton, Nicole Phan, Maria Gomez-Caraballo, Hannah L. Archibald, Chendi Li, Cameron Fraser, Diamanda Rigas, Kristof Vajda, Lorin A. Ferris, Michael Lanuti, Cameron D. Wright, Kevin A. Raskin, Daniel P. Cahill, John H. Shin, Colleen Keyes, Lecia V. Sequist, Zofia Piotrowska, Anna F. Farago, Christopher G. Azzoli, Justin F. Gainor, Kristopher A. Sarosiek, Sean P. Brown, Angela Coxon, Cyril H. Benes, Paul E. Hughes and Aaron N. Hata. http://cancerdiscovery.aacrjournals.org/content/8/12/1598

Increased Synthesis of MCL-1 Protein Underlies Initial Survival of EGFR-Mutant Lung Cancer to EGFR Inhibitors and Provides a Novel Drug Target – Kyung-A Song, Yasuyuki Hosono, Crystal Turner, Sheeba Jacob, Timothy L. Lochmann, Yoshiko Murakami, Neha U. Patel, Jungoh Ham, Bin Hu, Krista M. Powell, Colin M. Coon, Brad E. Windle, Yuko Oya, Jennifer E. Koblinski, Hisashi Harada, Joel D. Leverson, Andrew J. Souers, Aaron N. Hata, Sosipatros Boikos, Yasushi Yatabe, Hiromichi Ebi and Anthony C. Faber. http://clincancerres.aacrjournals.org/content/24/22/5658

Survival of midbrain dopamine neurons depends on the Bcl2 factor Mcl1 – Edward J. Robinson, Sebastian P. Aguiar, Willemieke M. Kouwenhoven, Dorinde S. Starmans, Lars von Oerthel et al. https://www.nature.com/articles/s41420-018-0125-7

Other Bcl-2 family proteins

VDAC2 enables BAX to mediate apoptosis and limit tumor development – Hui San Chin, Mark X. Li, Iris K. L. Tan, Robert L. Ninnis, Boris Reljic, Kristen Scicluna, Laura F. Dagley, Jarrod J. Sandow, Gemma L. Kelly, Andre L. Samson, Stephane Chappaz, Seong L. Khaw, Catherine Chang, Andrew Morokoff, Kerstin Brinkmann, Andrew Webb, Colin Hockings, Cathrine M. Hall, Andrew J. Kueh, Michael T. Ryan, Ruth M. Kluck, Philippe Bouillet, Marco J. Herold, Daniel H. D. Gray, David C. S. Huang, Mark F. van Delft and Grant Dewson. https://www.nature.com/articles/s41467-018-07309-4

Mannose impairs tumour growth and enhances chemotherapy – Pablo Sierra Gonzalez, James O’Prey, Simone Cardaci, Valentin J. A. Barthet, Jun-ichi Sakamaki, Florian Beaumatin, Antonia Roseweir, David M. Gay, Gillian Mackay, Gaurav Malviya, Elżbieta Kania, Shona Ritchie, Alice D. Baudot, Barbara Zunino, Agata Mrowinska, Colin Nixon, Darren Ennis, Aoisha Hoyle, David Millan, Iain A. McNeish, Owen J. Sansom, Joanne Edwards and Kevin M. Ryan. https://www.nature.com/articles/s41586-018-0729-3

Venetoclax with azacitidine disrupts energy metabolism and targets leukemia stem cells in patients with acute myeloid leukemia – Daniel A. Pollyea, Brett M. Stevens[…], Craig T. Jordan. https://www.nature.com/articles/s41591-018-0233-1

And the companion paper:
Inhibition of Amino Acid Metabolism Selectively Targets Human Leukemia Stem Cells – Courtney L. Jones, Brett M. Stevens, Angelo D’Alessandro, Julie A. Reisz, Rachel Culp-Hill, Travis Nemkov, Shanshan Pei, Nabilah Khan, Biniam Adane, Haobin Ye, Anna Krug, Dominik Reinhold, Clayton Smith, James DeGregori, Daniel A. Pollyea, Craig T. Jordan. https://www.cell.com/cancer-cell/fulltext/S1535-6108(18)30471-9

Tamoxifen overrides autophagy inhibition in Beclin-1-deficient glioma cells and their resistance to adenovirus-mediated oncolysis via upregulation of PUMA and BAX – Natalya V. Kaverina, Zaira G. Kadagidze, Anton V. Borovjagin, Apollon I. Karseladze, Chung Kwon Kim, Maciej S. Lesniak, Jason Miska, Peng Zhang, Maria A. Baryshnikova, Ting Xiao, David Ornelles, Charles Cobbs, Andrey Khramtsov and Ilya V. Ulasov. https://www.nature.com/articles/s41388-018-0395-9

NOXA genetic amplification or pharmacologic induction primes lymphoma cells to BCL2 inhibitor-induced cell death – Yuxuan Liu, Patrizia Mondello, Tatiana Erazo, Neeta Bala Tannan, Zahra Asgari, Elisa de Stanchina, Gouri Nanjangud, Venkatraman E. Seshan, Shenqiu Wang, Hans-Guido Wendel and Anas Younes. http://www.pnas.org/content/115/47/12034?etoc=

Cytoplasmic pro-apoptotic function of the tumor suppressor p73 is mediated through a modified mode of recognition of the anti-apoptotic regulator Bcl-XL – Mi-Kyung Yoon, Bu-Yeon Kim, Ji-Young Lee, Ji-Hyang Ha, Sung Ah Kim, Dong-Hwa Lee, Min-Sung Lee, Mi-Kyung Lee, Jin Sun Choi, Jin Hwa Cho, Jeong-Hoon Kim, Sunhong Kim, Jaewhan Song, Sung Goo Park, Byoung Chul Park, Kwang-Hee Bae, Sang Un Choi and Seung-Wook Chi. http://www.jbc.org/content/early/2018/11/14/jbc.RA118.003061.abstract


Caspases maintain tissue integrity by an apoptosis-independent inhibition of cell migration and invasion – Anna Gorelick-Ashkenazi, Ron Weiss, Lena Sapozhnikov, Anat Florentin, Lama Tarayrah-Ibraheim, Dima Dweik, Keren Yacobi-Sharon and Eli Arama. https://www.nature.com/articles/s41467-018-05204-6

Identification of a novel caspase cleavage site in huntingtin that regulates mutant huntingtin clearance – Dale D. O. Martin, Mandi E. Schmidt, Yen T. Nguyen, Nikola Lazic and Michael R. Hayden. https://www.fasebj.org/doi/abs/10.1096/fj.201701510RRR?ai=ts&ui=ly8&af=T

14‐3‐3 protein masks the nuclear localization sequence of caspase‐2 – Aneta Smidova, Miroslava Alblova, Dana Kalabova, Katarina Psenakova, Michal Rosulek, Petr Herman, Tomas Obsil, Veronika Obsilova. https://febs.onlinelibrary.wiley.com/doi/10.1111/febs.14670

Tri-arginine exosite patch of caspase-6 recruits substrates for hydrolysis – Derek J MacPherson, Caityln L Mills, Mary Jo Ondrechen and Jeanne A. Hardy. http://www.jbc.org/content/early/2018/11/12/jbc.RA118.005914.abstract

p53 accumulation following cytokinesis failure in the absence of caspase-2 (letter) – Yoon Lim, Dylan De Bellis, Loretta Dorstyn and Sharad Kumar. https://www.nature.com/articles/s41418-018-0161-0

microRNA-378 promotes autophagy and inhibits apoptosis in skeletal muscle – Yan Li, Jingjing Jiang, Wei Liu, Hui Wang, Lei Zhao, Shengnan Liu, Peng Li, Shengjie Zhang, Chao Sun, Yuting Wu, Shuxian Yu, Xihua Li, Hui Zhang, Haifeng Qian, Duo Zhang, Feifan Guo, Qiwei Zhai, Qiurong Ding, Li Wang and Hao Ying. http://www.pnas.org/content/115/46/E10849?etoc=

Platelet CD36 signaling through ERK5 promotes caspase-dependent procoagulant activity and fibrin deposition in vivo – Moua Yang, Andaleb Kholmukhamedov, Marie L. Schulte, Brian C. Cooley, Na’il O. Scoggins, Jeremy P. Wood, Scott J. Cameron, Craig N. Morrell, Shawn M. Jobeand Roy L. Silverstein. http://www.bloodadvances.org/content/2/21/2848.abstract?etoc


Axonal degeneration induced by glutamate excitotoxicity is mediated by necroptosis – Diego E. Hernández, Natalia A. Salvadores, Guillermo Moya-Alvarado, Romina J. Catalán, Francisca C. Bronfman and Felipe A. Court. http://jcs.biologists.org/content/131/22/jcs214684?etoc

Soluble TNF-like weak inducer of apoptosis (TWEAK) enhances poly(I:C)-induced RIPK1-mediated necroptosis – Mohamed A. Anany, Jennifer Kreckel, Simone Füllsack, Alevtina Rosenthal, Christoph Otto, Daniela Siegmund and Harald Wajant. https://www.nature.com/articles/s41419-018-1137-1

hsa-miR-500a-3P alleviates kidney injury by targeting MLKL-mediated necroptosis in renal epithelial cells – Ling Jiang, Xue-Qi Liu, Qiuying Ma, Qin Yang, Li Gao, Hai-Di Li, Jia-Nan Wang, Biao Wei, Jiagen Wen, Jun Li, Yong-Gui Wu and Xiao-Ming Meng. https://www.fasebj.org/doi/abs/10.1096/fj.201801711R?ai=ts&ui=ly8&af=T


The Proton-Coupled Monocarboxylate Transporter Hermes Is Necessary for Autophagy during Cell Death – Panagiotis D. Velentzas, Lejie Zhang, Gautam Das, Tsun-Kai Chang, Charles Nelson, William R. Kobertz, Eric H. Baehrecke. https://www.cell.com/developmental-cell/fulltext/S1534-5807(18)30744-5

Intracellular transport is accelerated in early apoptotic cells – Bo Li, Shuo-Xing Dou, Jing-Wen Yuan, Yu-Ru Liu, Wei Li, Fangfu Ye, Peng-Ye Wang and Hui Li. http://www.pnas.org.sire.ub.edu/content/115/48/12118?etoc=

The yeast mitochondrial permeability transition is regulated by reactive oxygen species, endogenous Ca2+ and Cpr3, mediating cell death – Yoshiko Kamei, Masami Koushi, Yasunori Aoyama, Rei Asakai. https://www.sciencedirect.com/science/article/pii/S000527281830197X

microRNAs selectively protect hub cells of the germline stem cell niche from apoptosis – Marina Volin, Maayan Zohar-Fux, Oren Gonen, Lilach Porat-Kuperstein and Hila Toledano. http://jcb.rupress.org/content/217/11/3829?etoc


FLIP as a therapeutic target in cancer – Luke Humphreys, Margarita Espona‐Fiedler, Daniel B. Longley. https://febs.onlinelibrary.wiley.com/doi/10.1111/febs.14523

Counting on Death – Quantitative aspects of Bcl‐2 family regulation – Annika Hantusch, Markus Rehm, Thomas Brunner. https://febs.onlinelibrary.wiley.com/doi/10.1111/febs.14516

Cell-in-cell phenomena in cancer – Stefano Fais and Michael Overholtzer. https://www.nature.com/articles/s41568-018-0073-9

FADD at the Crossroads between Cancer and Inflammation – Sara Mouasni, Léa Tourneur. https://www.cell.com/trends/immunology/fulltext/S1471-4906(18)30189-3

Hematologic Tumor Cell Resistance to the BCL-2 Inhibitor Venetoclax: A Product of Its Microenvironment? – Joel D. Leverson and Dan Cojocari. https://www.frontiersin.org/articles/10.3389/fonc.2018.00458/full

Dependence receptors – the dark side awakens – Ana‐Maria Negulescu, Patrick Mehlen. https://febs.onlinelibrary.wiley.com/doi/10.1111/febs.14507


Unleashing Blocked Apoptosis in Cancer Cells: New MCL1 Inhibitors Find Their Groove – Brian Leber, Justin Kale and David W. Andrews. http://cancerdiscovery.aacrjournals.org/content/8/12/1511?

TBK1 and IKKε restrain cell death – Klaus Heger and Vishva M. Dixit. https://www.nature.com/articles/s41556-018-0239-4

Timed degradation of Mcl-1 controls mitotic cell death – Paul R. Clarke, Lindsey A. Allan and Agnieszka Skowyra. https://www.tandfonline.com/doi/full/10.1080/23723556.2018.1516450

Necroptosis is key to axonal degeneration after excitotoxicity. http://jcs.biologists.org/content/131/22/e2202?etoc

ApoList – October 2018

Bcl-2 family proteins

Humanized Mcl-1 mice enable accurate preclinical evaluation of MCL-1 inhibitors destined for clinical use – Margs S. Brennan, Catherine Chang, Lin Tai, Guillaume Lessene, Andreas  Strasser, Grant Dewson, Gemma L. Kelly and Marco J. Herold. http://bloodjournal.org/content/132/15/1573.abstract?etoc

Discovery of a small-molecule inhibitor of specific serine residue BAD phosphorylation – Vijay Pandey, Baocheng Wang, Chakrabhavi Dhananjaya Mohan, Ainiah Rushdiana Raquib, Shobith Rangappa, Venkatachalaiah Srinivasa, Julian E. Fuchs, Kesturu S. Girish, Tao Zhu, Andreas Bender, Lan Ma, Zhinan Yin, Basappa, Kanchugarakoppal S. Rangappa and Peter E. Lobie. http://www.pnas.org/content/115/44/E10505?etoc=

Activation of the apoptotic pathway during prolonged prometaphase blocks daughter cell proliferation – Yumi Uetake and Greenfield Sluder. https://www.molbiolcell.org/doi/10.1091/mbc.E18-01-0026?ai=s5&ui=2oy6&af=T

Ursolic acid facilitates apoptosis in rheumatoid arthritis synovial fibroblasts by inducing SP1-mediated Noxa expression and proteasomal degradation of Mcl-1 – Eugene Y. Kim, Kuladeep Sudini, Anil K. Singh, Mahamudul Haque, Douglas Leaman, Sadik Khuder and Salahuddin Ahmed. https://www.fasebj.org/doi/abs/10.1096/fj.201800425R?ai=s4&ui=ly8&af=T

Tyrosine Kinase Inhibitors Increase MCL1 Degradation and in Combination with BCLXL/BCL2 Inhibitors Drive Prostate Cancer Apoptosis – Seiji Arai, Oliver Jonas, Matthew A. Whitman, Eva Corey, Steven P. Balk and Sen Chen. http://clincancerres.aacrjournals.org/content/24/21/5458

Death receptors

CD95/Fas ligand mRNA is toxic to cells – Will Putzbach, Ashley Haluck-Kangas … Marcus E Peter. https://elifesciences.org/articles/38621

Linear ubiquitination of cFLIP induced by LUBAC contributes to TNFa-induced apoptosis – Yong Tang, Donghyun Joo, Guangna Liu, Hailin Tu, Jeffrey You, Jianping Jin, Xueqiang Zhao, Mien-Chie Hung and Xin Lin. http://www.jbc.org/content/early/2018/10/25/jbc.RA118.005449.abstract


Picomolar zinc binding modulates formation of Bcl10-nucleating assemblies of the caspase recruitment domain (CARD) of CARD9 – Michael J. Holliday, Ryan Ferrao, Gladys de Leon Boenig, Alberto Estevez, Elizabeth Helgason, Alexis Rohou, Erin C. Dueber and Wayne J. Fairbrother. http://www.jbc.org/content/293/43/16803.abstract.html

Cryo-EM structures of ASC and NLRC4 CARD filaments reveal a unified mechanism of nucleation and activation of caspase-1 – Yang Li, Tian-Min Fu, Alvin Lu, Kristen Witt, Jianbin Ruan, Chen Shen and Hao Wu. http://www.pnas.org/content/115/43/10845?etoc=


LC3-Associated Phagocytosis in Myeloid Cells Promotes Tumor Immune Tolerance – Larissa D. Cunha, Mao Yang, Robert Carter, Clifford Guy, Lacie Harris, Jeremy C. Crawford, Giovanni Quarato, Emilio Boada-Romero, Halime Kalkavan, Michael D.L. Johnson, Sivaraman Natarajan, Meghan E. Turnis, David Finkelstein, Joseph T. Opferman, Charles Gawad, Douglas R. Green. https://www.cell.com/cell/fulltext/S0092-8674(18)31122-X

Regulatory T Cells Promote Macrophage Efferocytosis during Inflammation Resolution – Jonathan D. Proto, Amanda C. Doran, Galina Gusarova, Arif Yurdagul Jr., Erdi Sozen, Manikandan Subramanian, Mohammad N. Islam, Christina C. Rymond, Jasper Du, Jaime Hook, George Kuriakose, Jahar Bhattacharya, Ira Tabas. https://www.cell.com/immunity/fulltext/S1074-7613(18)30335-2

RAB-35 and ARF-6 GTPases Mediate Engulfment and Clearance Following Linker Cell-Type Death – Lena M. Kutscher, Wolfgang Keil, Shai Shaham. https://www.cell.com/developmental-cell/fulltext/S1534-5807(18)30685-3

Apoptotic β-cells induce macrophage reprogramming under diabetic conditions – Meliza G. Ward, Ge Li and Mingming Hao. http://www.jbc.org/content/293/42/16160.abstract.html


The glutathione redox system is essential to prevent ferroptosis caused by impaired lipid metabolism in clear cell renal cell carcinoma – Heike Miess, Beatrice Dankworth, Arvin M. Gouw, Mathias Rosenfeldt, Werner Schmitz, Ming Jiang, Becky Saunders, Michael Howell, Julian Downward, Dean W. Felsher, Barrie Peck and Almut Schulze. https://www.nature.com/articles/s41388-018-0315-z

Activation of ferritinophagy is required for the RNA-binding protein ELAVL1/HuR to regulate ferroptosis in hepatic stellate cells – Zili Zhang, Zhen Yao, Ling Wang, Hai Ding, Jiangjuan Shao, Anping Chen, Feng Zhang and Shizhong Zheng. https://www.tandfonline.com/doi/full/10.1080/15548627.2018.1503146


Mixed Lineage Kinase Domain-like Protein MLKL Breaks Down Myelin following Nerve Injury – Zhengxin Ying, Chenjie Pan, Tianyu Shao, Liqing Liu, Lin Li, Dejia Guo, Sitao Zhang, Tianyi Yuan, Ran Cao, Zhaodi Jiang, She Chen, Fengchao Wang, Xiaodong Wang. https://www.cell.com/molecular-cell/fulltext/S1097-2765(18)30782-2

Global Profiling of Proteolysis from the Mitochondrial Amino Terminome during Early Intrinsic Apoptosis Prior to Caspase-3 Activation – Natalie C. Marshall, Theo Klein, Maichael Thejoe, Niklas von Krosigk, Jayachandran Kizhakkedathu, B. Brett Finlay and Christopher M. Overall. https://pubs.acs.org/doi/10.1021/acs.jproteome.8b00675#.W9q0UN6qJiJ

Siglec-7 engagement by GBS β-protein suppresses pyroptotic cell death of natural killer cells – Jerry J. Fong, Chih-Ming Tsai, Sudeshna Saha, Victor Nizet, Ajit Varki and Jack D. Bui. http://www.pnas.org/content/115/41/10410?etoc=

Subcellular Hsp70 Inhibitors Promote Cancer Cell Death via Different Mechanisms – Sang-Hyun Park, Kyung-Hwa Baek, Insu Shin, Injae Shin. https://www.sciencedirect.com/science/article/pii/S2451945618302241


Topology of active, membrane-embedded Bax in the context of a toroidal pore – Stephanie Bleicken, Tufa E. Assafa, Carolin Stegmueller, Alice Wittig, Ana J. Garcia-Saez and Enrica Bordignon. https://www.nature.com/articles/s41418-018-0184-6

Neurophagy, the phagocytosis of live neurons and synapses by glia, contributes to brain development and disease – Anna Vilalta, Guy C. Brown. https://febs.onlinelibrary.wiley.com/doi/10.1111/febs.14323

No Parkin Zone: Mitophagy without Parkin – Elodie Villa, Sandrine Marchetti, Jean-Ehrland Ricci. https://www.cell.com/trends/cell-biology/fulltext/S0962-8924(18)30125-9


MIM through MOM: the awakening of Bax and Bak pores – Katia Cosentino, Ana J García‐Sáez. http://emboj.embopress.org/content/37/17/e100340

MLKL Reveals Its Friendly Face: A Role in Nerve Regeneration – Peter Vandenabeele, Wim Declercq, Ria Roelandt, Tom Vanden Berghe. https://www.cell.com/molecular-cell/fulltext/S1097-2765(18)30885-2

Neighbourhood deaths cause a switch in cancer subtype – Eli Pikarsky. https://www.nature.com/articles/d41586-018-06217-3

Neighbourly deaths dictate fatehttps://www.nature.com/articles/s41568-018-0064-x

Annual Meeting of the International Society of Cancer Metabolism (ISCaM): Cancer Metabolism – Sofia Avnet, Nicola Baldini, Lucie Brisson, Angelo De Milito, Angela M. Otto, Silvia Pastoreková, Paolo E. Porporato, Gyorgy Szabadkai and Pierre Sonveaux. https://www.frontiersin.org/articles/10.3389/fonc.2018.00329/full

ApoList – September 2018


Caspases and cFLIP

ER Stress Drives Lipogenesis and Steatohepatitis via Caspase-2 Activation of S1P – Ju Youn Kim, Ricard Garcia-Carbonell, Shinichiro Yamachika, Peng Zhao, Debanjan Dhar, Rohit Loomba, Randal J. Kaufman, Alan R. Saltiel, Michael Karin. https://www.cell.com/cell/fulltext/S0092-8674(18)31036-5

Caspase-1 inhibition alleviates cognitive impairment and neuropathology in an Alzheimer’s disease mouse model – Joseph Flores, Anastasia Noël, Bénédicte Foveau, Jeffrey Lynham, Clotilde Lecrux & Andréa C. LeBlanc. https://www.nature.com/articles/s41467-018-06449-x

Inhibitor of apoptosis proteins (IAPs) mediate collagen type XI alpha 1-driven cisplatin resistance in ovarian cancer – Miran Rada, Sameera Nallanthighal, Jennifer Cha, Kerry Ryan, Jessica Sage, Catherine Eldred, Maria Ullo, Sandra Orsulic & Dong-Joo Cheon. https://www.nature.com/articles/s41388-018-0297-x

Hypercapnia increases airway smooth muscle contractility via caspase-7-mediated miR-133a-RhoA signaling – Masahiko Shigemura , Emilia Lecuona, Martín Angulo, Tetsuya Homma, Diego A. Rodríguez, Francisco J. Gonzalez-Gonzalez, Lynn C. Welch, Luciano Amarelle, Seok-Jo Kim, Naftali Kaminski, G. R. Scott Budinger, Julian Solway, Jacob I. Sznajder. http://stm.sciencemag.org/content/10/457/eaat1662

PIDD-dependent activation of caspase-2-mediated mitochondrial injury in E1A-induced cellular sensitivity to macrophage nitric oxide-induced apoptosis – Jay R. Radke, Iris Figueroa, John M. Routes & James L. Cook. https://www.nature.com/articles/s41420-018-0100-3

Release of c-FLIP brake selectively sensitizes human cancer cells to TLR3-mediated apoptosis – Lugain Alkurdi, François Virard, Béatrice Vanbervliet, Kathrin Weber, Florent Toscano, Marc Bonnin, Nolwenn Le Stang, Sylvie Lantuejoul, Olivier Micheau, Toufic Renno, Serge Lebecque & Yann Estornes. https://www.nature.com/articles/s41419-018-0850-0

Bcl-2 family proteins

Phosphorylation switches Bax from promoting to inhibiting apoptosis thereby increasing drug resistance – Justin Kale, Ozgur Kutuk, Glauber Costa Brito, Tallulah S Andrews, Brian Leber, Anthony Letai and David W Andrews. http://EMBOr.embopress.org/content/19/9/e45235?etoc

Topology of active, membrane-embedded Bax in the context of a toroidal pore – Stephanie Bleicken, Tufa E. Assafa, Carolin Stegmueller, Alice Wittig, Ana J. Garcia-Saez & Enrica Bordignon. https://www.nature.com/articles/s41418-018-0184-6

Atypical APC/C‐dependent degradation of Mcl‐1 provides an apoptotic timer during mitotic arrest – Lindsey A Allan, Agnieszka Skowyra, Katie I Rogers, Désirée Zeller and Paul R Clarke. http://EMBOJ.embopress.org/content/37/17/e96831?etoc

Comprehensive Safety Analysis of Venetoclax Monotherapy for Patients with Relapsed/Refractory Chronic Lymphocytic Leukemia – Matthew S. Davids, Michael Hallek, William Wierda, Andrew W. Roberts, Stephan Stilgenbauer, Jeffrey A. Jones, John F. Gerecitano, Su Young Kim, Jalaja Potluri, Todd Busman, Andrea Best, Maria E. Verdugo, Elisa Cerri, Monali Desai, Peter Hillmen and John F. Seymour. http://clincancerres.aacrjournals.org/content/24/18/4371

SNAP23 regulates BAX-dependent adipocyte programmed cell death independently of canonical macroautophagy – Daorong Feng, Dulguun Amgalan, Rajat Singh, Jianwen Wei, Jennifer Wen, Tszki Peter Wei, Timothy E. McGraw, Richard N. Kitsis, and Jeffrey E. Pessin. https://www.jci.org/articles/view/99217

BCL-2 selective inhibitor ABT-199 primes rhabdomyosarcoma cells to histone deacetylase inhibitor-induced apoptosis – Ulrike Heinicke, Tinka Haydn, Sarah Kehr, Meike Vogler & Simone Fulda. https://www.nature.com/articles/s41388-018-0212-5

Bcl-xl as the most promising Bcl-2 family member in targeted treatment of chondrosarcoma – Yvonne de Jong, David Monderer, Emeline Brandinelli, Morgane Monchanin, Brendy E. van den Akker, Jolieke G. van Oosterwijk, Jean Yves Blay, Aurélie Dutour & Judith V. M. G. Bovée. https://www.nature.com/articles/s41389-018-0084-0

Mex-3B induces apoptosis by inhibiting miR-92a access to the Bim-3’UTR – Takeaki Oda, Yusuke Yamazumi, Takatoshi Hiroko, Atsushi Kamiya, Saori Kiriya, Saki Suyama, Yumi Shiozaki-Sato & Tetsu Akiyama. https://www.nature.com/articles/s41388-018-0336-7

MEK inhibitors induce apoptosis via FoxO3a-dependent PUMA induction in colorectal cancer cells – Lin Lin, Dapeng Ding, Yanmei Jiang, Yan Li & Shijun Li. https://www.nature.com/articles/s41389-018-0078-y

Subtle Changes in the Levels of BCL-2 Proteins Cause Severe Craniofacial Abnormalities – Stephanie Grabow, Andrew J. Kueh, Francine Ke, Hannah K. Vanyai, Bilal N. Sheikh, Michael A. Dengler, William Chiang, Samantha Eccles, Ian M. Smyth, Lynelle K. Jones, Frederic J. de Sauvage, Mark Scott, Lachlan Whitehead, Anne K. Voss, Andreas Strasser. https://www.cell.com/cell-reports/fulltext/S2211-1247(18)31334-2

Misoprostol regulates Bnip3 repression and alternative splicing to control cellular calcium homeostasis during hypoxic stress – Jared T. Field, Matthew D. Martens, Wajihah Mughal, Yan Hai, Donald Chapman, Grant M. Hatch, Tammy L. Ivanco, William Diehl-Jones & Joseph W. Gordon. https://www.nature.com/articles/s41420-018-0104-z

BH3 mimetics induce apoptosis independent of DRP-1 in melanoma – Nabanita Mukherjee, Andrew Strosnider, Bay Vagher, Karoline A. Lambert, Sarah Slaven, William A. Robinson, Carol M. Amato, Kasey L. Couts, Judson G. T. Bemis, Jacqueline A. Turner, David A. Norris& Yiqun G. Shellman. https://www.nature.com/articles/s41419-018-0932-z

Sensitizing non-small cell lung cancer to BCL-xL-targeted apoptosis – Qi Shen, Jun Li, Junhua Mai, Zhe Zhang, Andrew Fisher, Xiaoyan Wu, Zhaoqi Li, Maricela R. Ramirez, Shuqing Chen & Haifa Shen. https://www.nature.com/articles/s41419-018-1040-9

Death receptors

LUBAC prevents lethal dermatitis by inhibiting cell death induced by TNF, TRAIL and CD95L – Lucia Taraborrelli, Nieves Peltzer, Antonella Montinaro, Sebastian Kupka, Eva Rieser, Torsten Hartwig, Aida Sarr, Maurice Darding, Peter Draber, Tobias L. Haas, Ayse Akarca, Teresa Marafioti, Manolis Pasparakis, John Bertin, Peter J. Gough, Philippe Bouillet, Andreas Strasser, Martin Leverkus, John Silke & Henning Walczak. https://www.nature.com/articles/s41467-018-06155-8

Delivery of a TNF-α–derived peptide by nanoparticles enhances its antitumor activity by inducing cell-cycle arrest and caspase-dependent apoptosis – Qiuxia Yan, Xueming Chen, Huizhen Gong, Pei Qiu, Xing Xiao, Shiying Dang, An Hong, and Yi Ma. https://www.fasebj.org/doi/abs/10.1096/fj.201800377R?ai=ts&ui=ly8&af=T

Platelet-RBC interaction mediated by FasL/FasR induces procoagulant activity important for thrombosis – Christoph Klatt, Irena Krüger, Saskia Zey, Kim-Jürgen Krott, Martina Spelleken, Nina Sarah Gowert, Alexander Oberhuber, Lena Pfaff, Wiebke Lückstädt, Kerstin Jurk, Martin Schaller, Hadi Al-Hasani, Jürgen Schrader, Steffen Massberg, Konstantin Stark, Hubert Schelzig, Malte Kelm, and Margitta Elvers. https://www.jci.org/articles/view/92077

Elevated A20 promotes TNF-induced and RIPK1-dependent intestinal epithelial cell death – Ricard Garcia-Carbonell, Jerry Wong, Ju Youn Kim, Lisa Abernathy Close, Brigid S. Boland, Thomas L. Wong, Philip A. Harris, Samuel B. Ho, Soumita Das, Peter B. Ernst, Roman Sasik, William J. Sandborn, John Bertin, Pete J. Gough, John T. Chang, Michelle Kelliher, David Boone, Monica Guma, and Michael Karin. http://www.pnas.org/content/115/39/E9192?etoc=

K6 linked polyubiquitylation of FADD by CHIP prevents death inducing signaling complex formation suppressing cell death – Jinho Seo, Eun-Woo Lee, Jihye Shin, Daehyeon Seong, Young Woo Nam, Manhyung Jeong, Seon-Hyeong Lee, Cheolju Lee & Jaewhan Song. https://www.nature.com/articles/s41388-018-0323-z

TNFR2 unlocks a RIPK1 kinase activity-dependent mode of proinflammatory TNFR1 signaling – Daniela Siegmund, Martin Ehrenschwender & Harald Wajant. https://www.nature.com/articles/s41419-018-0973-3

Ceramide synthase-6 confers resistance to chemotherapy by binding to CD95/Fas in T-cell acute lymphoblastic leukemia – Dattesh Verlekar, Sung-Jen Wei, Hwangeui Cho, Shengping Yang & Min H. Kang. https://www.nature.com/articles/s41419-018-0964-4

TNFα sensitizes hepatocytes to FasL-induced apoptosis by NFκB-mediated Fas upregulation – Laura Faletti, Lukas Peintner, Simon Neumann, Sandra Sandler, Thomas Grabinger, Sabine Mac Nelly, Irmgard Merfort, Chun-Hao Huang, Darjus Tschaharganeh, Tae-Won Kang, Florian Heinzmann, Luana D’Artista, Ulrich Maurer, Thomas Brunner, Scott Lowe, Lars Zender & Christoph Borner. https://www.nature.com/articles/s41419-018-0935-9

Necroptosis, RIP kinases, MLKL

Necroptosis microenvironment directs lineage commitment in liver cancer – Marco Seehawer, Florian Heinzmann, Luana D’Artista, Jule Harbig, Pierre-François Roux, Lisa Hoenicke, Hien Dang, Sabrina Klotz, Lucas Robinson, Grégory Doré, Nir Rozenblum, Tae-Won Kang, Rishabh Chawla, Thorsten Buch, Mihael Vucur, Mareike Roth, Johannes Zuber, Tom Luedde, Bence Sipos, Thomas Longerich, Mathias Heikenwälder, Xin Wei Wang, Oliver Bischof & Lars Zender. https://www.nature.com/articles/s41586-018-0519-y

TBK1 Suppresses RIPK1-Driven Apoptosis and Inflammation during Development and in Aging – Daichao Xu, Taijie Jin, Hong Zhu, Hongbo Chen, Dimitry Ofengeim, Chengyu Zou, Lauren Mifflin, Lifeng Pan, Palak Amin, Wanjin Li, Bing Shan, Masanori Gomi Naito, Huyan Meng, Ying Li, Heling Pan, Liviu Aron, Xian Adiconis, Joshua Z. Levin, Bruce A. Yankner, Junying Yuan. https://www.cell.com/cell/fulltext/S0092-8674(18)30969-3

Necroptosis mediates myofibre death in dystrophin-deficient mice – Jennifer E. Morgan, Alexandre Prola, Virginie Mariot, Veronica Pini, Jinhong Meng, Christophe Hourde, Julie Dumonceaux, Francesco Conti, Frederic Relaix, Francois-Jerôme Authier, Laurent Tiret, Francesco Muntoni & Maximilien Bencze. https://www.nature.com/articles/s41467-018-06057-9

RIPK3-MLKL-mediated necroinflammation contributes to AKI progression to CKD – Hui Chen, Yulu Fang, Jianfeng Wu, Hong Chen, Zhenhuan Zou, Xiaohong Zhang, Jing Shao & Yanfang Xu. https://www.nature.com/articles/s41419-018-0936-8

RIPK1 is a critical modulator of both tonic and TLR-responsive inflammatory and cell death pathways in human macrophage differentiation – Julian Buchrieser, Maria Jose Oliva-Martin, Michael D. Moore, Joshua C. D. Long, Sally A. Cowley, Jose Antonio Perez-Simón, William James & Jose Luis Venero. https://www.nature.com/articles/s41419-018-1053-4

BRAF and AXL oncogenes drive RIPK3 expression loss in cancer – Ayaz Najafov , Ioannis K. Zervantonakis, Adnan K. Mookhtiar, Patricia Greninger, Ryan J. March, Regina K. Egan, Hoang Son Luu, Daniel G. Stover, Ursula A. Matulonis, Cyril H. Benes, Junying Yuan. https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.2005756

The pseudokinase MLKL activates PAD4-dependent NET formation in necroptotic neutrophils – Akshay A. D’Cruz , Mary Speir, Meghan Bliss-Moreau, Sylvia Dietrich, Shu Wang, Alyce A. Chen, Mathilde Gavillet, Arshed Al-Obeidi, Kate E. Lawlor, James E. Vince, Michelle A. Kelliher, Razq Hakem, Manolis Pasparakis, David A. Williams, Maria Ericsson, Ben A. Croker. http://stke.sciencemag.org/content/11/546/eaao1716

The brace helices of MLKL mediate interdomain communication and oligomerisation to regulate cell death by necroptosis – Katherine A. Davies, Maria C. Tanzer, Michael D. W. Griffin, Yee Foong Mok, Samuel N. Young, Rui Qin, Emma J. Petrie, Peter E. Czabotar, John Silke & James M. Murphy. https://www.nature.com/articles/s41418-018-0061-3


Natural killer cells induce distinct modes of cancer cell death: Discrimination, quantification and modulation of apoptosis, necrosis and mixed forms – Christian S Backes, Kim S Friedmann, Sebastian Mang, Arne Knörck, Markus Hoth and Carsten Kummerow. http://www.jbc.org/content/early/2018/09/06/jbc.RA118.004549.abstract

DPP8/DPP9 inhibitor-induced pyroptosis for treatment of acute myeloid leukemia – Darren C. Johnson, Cornelius Y. Taabazuing, Marian C. Okondo, Ashley J. Chui, Sahana D. Rao, Fiona C. Brown, Casie Reed, Elizabeth Peguero, Elisa de Stanchina, Alex Kentsis & Daniel A. Bachovchin. https://www.nature.com/articles/s41591-018-0082-y

The small GTPase RAB-35 defines a third pathway that is required for the recognition and degradation of apoptotic cells – Ryan Haley, Ying Wang, Zheng Zhou. https://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1007558

Cell-to-Cell Heterogeneity in p38-Mediated Cross-Inhibition of JNK Causes Stochastic Cell Death – Haruko Miura, Yohei Kondo, Michiyuki Matsuda, Kazuhiro Aoki. https://www.cell.com/cell-reports/fulltext/S2211-1247(18)31274-9

Tryparedoxin peroxidase-deficiency commits trypanosomes to ferroptosis-type cell death – Marta Bogacz, R Luise Krauth-Siegel. https://elifesciences.org/articles/37503

BAP1 links metabolic regulation of ferroptosis to tumour suppression – Yilei Zhang, Jiejun Shi, Xiaoguang Liu, Li Feng, Zihua Gong, Pranavi Koppula, Kapil Sirohi, Xu Li, Yongkun Wei, Hyemin Lee, Li Zhuang, Gang Chen, Zhen-Dong Xiao, Mien-Chie Hung, Junjie Chen, Peng Huang, Wei Li & Boyi Gan. https://www.nature.com/articles/s41556-018-0178-0

Gasdermin D Restrains Type I Interferon Response to Cytosolic DNA by Disrupting Ionic Homeostasis – Ishita Banerjee, Bharat Behl, Morena Mendonca, Gaurav Shrivastava, Ashley J. Russo, Antoine Menoret, Arundhati Ghosh, Anthony T. Vella, Sivapriya Kailasan Vanaja, Saumendra N. Sarkar, Katherine A. Fitzgerald, Vijay A.K. Rathinam. https://www.cell.com/immunity/fulltext/S1074-7613(18)30326-1

Dynein links engulfment and execution of apoptosis via CED-4/Apaf1 in C. elegans – Rikke Hindsgaul Harders, Tine Hørning Morthorst, Anna Dippel Lande, Marianne Overgaard Hesselager, Ole Aalund Mandrup, Emøke Bendixen, Allan Stensballe & Anders Olsen. https://www.nature.com/articles/s41419-018-1067-y


Life, death and autophagy – Johnna Doherty & Eric H. Baehrecke. https://www.nature.com/articles/s41556-018-0201-5

Nutrient scavenging in cancer – Brendan T. Finicle, Vaishali Jayashankar & Aimee L. Edinger. https://www.nature.com/articles/s41568-018-0048-x

BCL-2 inhibition in AML: an unexpected bonus? – Marina Konopleva and Anthony Letai. http://bloodjournal.org/content/132/10/1007.abstract?etoc

Apoptosis-Inducing Factor (AIF) in Physiology and Disease: The Tale of a Repented Natural Born Killer – Bano D, Prehn JHM. https://linkinghub.elsevier.com/retrieve/pii/S2352-3964(18)30100-2

Autophagy-dependent cell death – where, how and why a cell eats itself to death – Shani Bialik, Santosh K. Dasari and Adi Kimchi. http://jcs.biologists.org/content/131/18/jcs215152?etoc

Apoptosis and necroptosis in the liver: a matter of life and death – Robert F. Schwabe & Tom Luedd. https://www.nature.com/articles/s41575-018-0065-y

The rise of apoptosis: targeting apoptosis in hematologic malignancies – Rebecca Valentin, Stephanie Grabow and Matthew S. Davids. http://bloodjournal.org/content/132/12/1248.abstract?etoc

The induction and consequences of Influenza A virus-induced cell death – Georgia K. Atkin-Smith, Mubing Duan, Weisan Chen & Ivan K. H. Poon. https://www.nature.com/articles/s41419-018-1035-6


Ion Man: GSDMD Punches Pores to Knock Out cGAS – Rebecca Feltham, James E. Vince. https://www.cell.com/immunity/fulltext/S1074-7613(18)30389-3

Tuning Apoptosis and Neuroinflammation: TBK1 Restrains RIPK1 – Haiyang Yu, Don W. Cleveland. https://www.cell.com/cell/fulltext/S0092-8674(18)31096-1

C. elegans RAB-35: Dual roles in apoptotic cell clearance – Christian E. Rocheleau. https://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1007534

Neighbourhood deaths cause a switch in cancer subtype – Eli Pikarsky. https://www.nature.com/articles/d41586-018-06217-3

Retraction: ROS and CHOP Are Critical for Dibenzylideneacetone to Sensitize Tumor Cells to TRAIL through Induction of Death Receptors and Downregulation of Cell Survival Proteinshttp://cancerres.aacrjournals.org/content/78/17/5185

Metabolic control of ferroptosis in cancer – Michael P. Murphy. https://www.nature.com/articles/s41556-018-0209-x