ApoList – August 2021


Bcl-2 family proteins


Breast cancer dependence on MCL-1 is due to its canonical anti-apoptotic function – Kirsteen J. Campbell, Susan M. Mason, Matthew L. Winder, Rosalie B. E. Willemsen, Catherine Cloix, Hannah Lawson, Nicholas Rooney, Sandeep Dhayade, Andrew H. Sims, Karen Blyth and Stephen W. G. Tait. https://www.nature.com/articles/s41418-021-00773-4

The conformational stability of pro-apoptotic BAX is dictated by discrete residues of the protein core – Noah B. Bloch, Thomas E. Wales, Michelle S. Prew, Hannah R. Levy, John R. Engen and Loren D. Walensky. https://www.nature.com/articles/s41467-021-25200-7

Hexokinases inhibit death receptor–dependent apoptosis on the mitochondria – Joachim Lauterwasser, Franziska Fimm-Todt, Aline Oelgeklaus, Annabell Schreiner, Kathrin Funk, Hugo Falquez-Medina, Ramona Klesse, Günther Jahreis, Ralf M. Zerbes, Katelyn O’Neill, Martin van der Laan, Xu Luo, and Frank Edlich. https://www.pnas.org/content/118/33/e2021175118.abstract

Tracing the evolutionary history of Ca 2+-signaling modulation by human Bcl-2: Insights from the Capsaspora owczarzaki IP 3 receptor ortholog – Nicolas Rosa, Victoria Shabardina, Hristina Ivanova, Arnau Sebé-Pedrós, David I Yule, Geert Bultynck. https://pubmed.ncbi.nlm.nih.gov/34400171/

Importance of Bcl-2-family proteins in murine hematopoietic progenitor and early B cells – Constanze Kurschat, Arlena Metz, Susanne Kirschnek and Georg Häcker. https://www.nature.com/articles/s41419-021-04079-8


BH3 mimetics


Long-term Follow-up of Patients with Relapsed or Refractory Non–Hodgkin Lymphoma Treated with Venetoclax in a Phase I, First-in-Human Study – Matthew S. Davids, Andrew W. Roberts, Vaishalee P. Kenkre, William G. Wierda, Abhijeet Kumar, Thomas J. Kipps, Michelle Boyer, Ahmed Hamed Salem, John C. Pesko, Jennifer A. Arzt, Margaret Mantas, Su Y. Kim and John F. Seymour. https://clincancerres.aacrjournals.org/content/27/17/4690

Therapeutic Synergy in Esophageal Cancer and Mesothelioma Is Predicted by Dynamic BH3 Profiling – Deborah R. Surman, Yuan Xu, Min-Jung Lee, Jane Trepel, Kate Brown, Maheshwari Ramineni, Taylor G. Splawn, Laurence P. Diggs, H. Courtney Hodges, Jeremy L. Davis, Hyun-Sung Lee, Bryan M. Burt and Robert Taylor Ripley. https://mct.aacrjournals.org/content/20/8/1469.long

Pharmacologic Targeting of Mcl-1 Induces Mitochondrial Dysfunction and Apoptosis in B-Cell Lymphoma Cells in a TP53- and BAX-Dependent Manner – Tingting Liu, Vi Lam, Elana Thieme, Duanchen Sun, Xiaoguang Wang, Fei Xu, Lili Wang, Olga V. Danilova, Zheng Xia, Jeffrey W. Tyner, Stephen E. Kurtz and Alexey V. Danilov. https://clincancerres.aacrjournals.org/content/27/17/4910

Constitutive BAK/MCL1 complexes predict paclitaxel and S63845 sensitivity of ovarian cancer – Dongyan Liu, Xiaonan Hou, Wangyu Wu, Valentina Zafagnin, Yunjian Li, Cristina Correia, Zhiyang Zhao, Chenggang Zhao, Zhirong Liu, Tao Zhang, Zhiyou Fang, Hongzhi Wang, Chao Xu, Saravut J. Weroha, Scott H. Kaufmann and Haiming Dai. https://www.nature.com/articles/s41419-021-04073-0


Death receptors and caspases


Caspase-8 mutations associated with head and neck cancer differentially retain functional properties related to TRAIL-induced apoptosis and cytokine induction – Zhibin Cui, Hadas Dabas, Brandon C. Leonard, Jamie V. Shiah, Jennifer R. Grandis and Daniel E. Johnson. https://www.nature.com/articles/s41419-021-04066-z

Hexokinases inhibit death receptor–dependent apoptosis on the mitochondria – Joachim Lauterwasser, Franziska Fimm-Todt, Aline Oelgeklaus, Annabell Schreiner, Kathrin Funk, Hugo Falquez-Medina, Ramona Klesse, Günther Jahreis, Ralf M. Zerbes, Katelyn O’Neill, Martin van der Laan, Xu Luo, and Frank Edlich. https://www.pnas.org/content/118/33/e2021175118.abstract

A unique death pathway keeps RIPK1 D325A mutant mice in check at embryonic day 10.5 – Yingying Zhang, Kai Huang, Yuxia Zhang, Tao Han, Lang Li, Chenchen Ruan, Ye-hsuan Sun, Wenke Shi, Wei Han, Su-qin Wu, Jing Song, Jun Liu, Jiahuai Han. https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3001304

Effects of intravitreal injection of siRNA against caspase-2 on retinal and optic nerve degeneration in air blast induced ocular trauma – Chloe N. Thomas, Alexandra Bernardo-Colón, Ella Courtie, Gareth Essex, Tonia S. Rex, Richard J. Blanch and Zubair Ahmed. https://www.nature.com/articles/s41598-021-96107-y


Ferroptosis


Peroxidation of n-3 and n-6 polyunsaturated fatty acids in the acidic tumor environment leads to ferroptosis-mediated anticancer effects – Emeline Dierge, Elena Debock, Céline Guilbaud, Cyril Corbet, Eric Mignolet, Louise Mignard, Estelle Bastien, Chantal Dessy, Yvan Larondelle, Olivier Feron. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(21)00233-3


Miscellanous


Macrophage and neutrophil death programs differentially confer resistance to tuberculosis – Michael Dominic Stutz, Cody Charles Allison, Samar Ojaimi, Simon Peter Preston, Marcel Doerflinger, Philip Arandjelovic, Lachlan Whitehead, Stefanie M. Bader, Daniel Batey, Marie-Liesse Asselin-Labat, Marco J. Herold, Andreas Strasser, Nicholas P. West, Marc Pellegrini. https://www.cell.com/immunity/fulltext/S1074-7613(21)00253-3

Cytotoxic T cells are able to efficiently eliminate cancer cells by additive cytotoxicity – Bettina Weigelin, Annemieke Th. den Boer, Esther Wagena, Kelly Broen, Harry Dolstra, Rob J. de Boer, Carl G. Figdor, Johannes Textor and Peter Friedl. https://www.nature.com/articles/s41467-021-25282-3


Reviews


Apoptosis – Fueling the oncogenic fire – Camila Castillo Ferrer, Kevin Berthenet, Gabriel Ichim. https://febs.onlinelibrary.wiley.com/doi/10.1111/febs.15624

Ferroptosis in the tumor microenvironment: perspectives for immunotherapy – Huanji Xu, Di Ye, Meiling Ren, Hongying Zhang, Feng Bi. https://www.cell.com/trends/molecular-medicine/fulltext/S1471-4914(21)00181-7

Caspase-2 as a master regulator of genomic stability – Gelina S. Kopeina, Boris Zhivotovsky. https://www.cell.com/trends/cell-biology/fulltext/S0962-8924(21)00048-9

Interactions of multidomain pro-apoptotic and anti-apoptotic proteins in cancer cell death – Alexander Chota, Blassan P. George, and Heidi Abrahamse. https://www.oncotarget.com/article/28031/text/


Comments


Mitochondria control pyroptosis – Nicholas J. Bernard. https://www.nature.com/articles/s41590-021-01017-w

TNF-dependent hyperactivation of RIPK1-dependent cytotoxic signaling during embryogenesis and inflammation – Edward S. Mocarski, Pratyusha Mandal. https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3001371

Ending on a sour note: Lipids orchestrate ferroptosis in cancer – Mike Lange, James A. Olzmann. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(21)00327-2

Editor Profile: Brent Derry. https://febs.onlinelibrary.wiley.com/doi/full/10.1111/febs.15893

ApoList – July 2021


Apoptosis and tissue homeostasis


Microenvironmental innate immune signaling and cell mechanical responses promote tumor growth – Jun Zhou, Erica Valentini, Michael Boutros. https://www.cell.com/developmental-cell/fulltext/S1534-5807(21)00485-8

Apoptotic cells represent a dynamic stem cell niche governing proliferation and tissue regeneration – Roi Ankawa, Nitzan Goldberger, Yahav Yosefzon, Elle Koren, Marianna Yusupova, Daniel Rosner, Alona Feldman, Shulamit Baror-Sebban, Yosef Buganim, David J. Simon, Marc Tessier-Lavigne, Yaron Fuchs. https://www.cell.com/developmental-cell/fulltext/S1534-5807(21)00486-X

Homeostatic apoptosis prevents competition-induced atrophy in follicular B cells – Stéphane Chappaz, Kate McArthur, Liam Kealy, Charity W. Law, Maximilien Tailler, Rachael M. Lane, Anna Lieschke, Matthew E. Ritchie, Kim L. Good-Jacobson, Andreas Strasser, Benjamin T. Kile. https://www.cell.com/cell-reports/fulltext/S2211-1247(21)00847-0


Bcl-2 family proteins


BCL-XL is crucial for progression through the adenoma-to-carcinoma sequence of colorectal cancer – Ramesh P, Lannagan TRM, Jackstadt R, Atencia Taboada L, Lansu N, Wirapati P, van Hooff SR, Dekker D, Pritchard J, Kirov AB, van Neerven SM, Tejpar S, Kops GJPL, Sansom OJ, Medema JP. https://www.nature.com/articles/s41418-021-00816-w

ER+ Breast Cancer Strongly Depends on MCL-1 and BCL-xL Anti-Apoptotic Proteins – Clara Alcon, Jorge Gómez Tejeda Zañudo, Reka Albert, Nikhil Wagle, Maurizio Scaltriti, Anthony Letai, Josep Samitier and Joan Montero. https://www.mdpi.com/2073-4409/10/7/1659

Virus-mediated inactivation of anti-apoptotic Bcl-2 family members promotes Gasdermin-E-dependent pyroptosis in barrier epithelial cells – Megan H. Orzalli, Aleksandra Prochera, Laurellee Payne, Avi Smith, Jonathan A. Garlick, Jonathan C. Kagan. https://www.cell.com/immunity/fulltext/S1074-7613(21)00174-6

An amphipathic Bax core dimer forms part of the apoptotic pore wall in the mitochondrial membrane – Fujiao Lv, Fei Qi, Zhi Zhang, Maorong Wen, Justin Kale, Alessandro Piai, Lingyu Du, Shuqing Wang, Liujuan Zhou, Yaqing Yang, Bin Wu, Zhijun Liu, Juan del Rosario, Justin Pogmore, James J Chou, David W Andrews, Jialing Lin, Bo OuYang. https://www.embopress.org/doi/full/10.15252/embj.2020106438

Guanylate-binding proteins induce apoptosis of leukemia cells by regulating MCL-1 and BAK – Yongyang Luo, Hanyong Jin, Je Hyeong Kim and Jeehyeon Bae. https://www.nature.com/articles/s41389-021-00341-y

Dynamic BH3 profiling identifies active BH3 mimetic combinations in non-small cell lung cancer – Danielle S. Potter, Ruochen Du, Patrick Bhola, Raphael Bueno and Anthony Letai. https://www.nature.com/articles/s41419-021-04029-4

Bcl-2/Bcl-xL inhibitor ABT-263 overcomes hypoxia-driven radioresistence and improves radiotherapy – Violetta Ritter, Franziska Krautter, Diana Klein, Verena Jendrossek and Justine Rudner. https://www.nature.com/articles/s41419-021-03971-7

Cell line-specific network models of ER+ breast cancer identify potential PI3Kα inhibitor resistance mechanisms and drug combinations – Jorge Gómez Tejeda Zañudo, Pingping Mao, Clara Alcon, Kailey Kowalski, Gabriela N Johnson, Guotai Xu, Jose Baselga, Maurizio Scaltriti, Anthony Letai, Joan Montero, Réka Albert and Nikhil Wagle. https://cancerres.aacrjournals.org/content/early/2021/07/12/0008-5472.CAN-21-1208


Death receptors


First-in-human DR5 PET reveals insufficient DR5 expression in patients with gastrointestinal cancer – Shujing Wang, Hua Zhu, Yingjie Li et al. https://jitc.bmj.com/content/9/7/e002926

TRAIL-receptor 2—a novel negative regulator of p53 – Anna Willms, Hella Schupp, Michelle Poelker, Alshaimaa Adawy, Jan Frederik Debus, Torsten Hartwig, Tim Krichel, Jürgen Fritsch, Steven Singh, Henning Walczak, Silvia von Karstedt, Heiner Schäfer and Anna Trauzold. https://www.nature.com/articles/s41419-021-04048-1

Reconstruction of the Fas-Based Death-Inducing Signaling Complex (DISC) Using a Protein–Protein Docking Meta-Approach – Sayyed Jalil Mahdizadeh, Melissa Thomas, and Leif A. Eriksson. https://pubs.acs.org/doi/10.1021/acs.jcim.1c00301

Antioxidant and food additive BHA prevents TNF cytotoxicity by acting as a direct RIPK1 inhibitor – Tom Delanghe, Jon Huyghe, Seungheon Lee, Dario Priem, Samya Van Coillie, Barbara Gilbert, Sze Men Choi, Peter Vandenabeele, Alexei Degterev, Gregory D. Cuny, Yves Dondelinger and Mathieu J. M. Bertrand. https://www.nature.com/articles/s41419-021-03994-0

PLEKHO2 inhibits TNFα-induced cell death by suppressing RIPK1 activation – Chenchen Zhou, Xueli Zhang, Cuiping Yang, Yuan He and Luo Zhang. https://www.nature.com/articles/s41419-021-04001-2


Caspases and c-FLIP


Characterization of caspase-7 interaction with RNA – Alexandre Desroches, Jean-Bernard Denault. https://portlandpress.com/biochemj/article-abstract/478/13/2681/229082

c-FLIP regulates autophagy by interacting with Beclin-1 and influencing its stability – Luana Tomaipitinca, Simonetta Petrungaro, Pasquale D’Acunzo, Angelo Facchiano, Amit Dubey, Salvatore Rizza, Federico Giulitti, Eugenio Gaudio, Antonio Filippini, Elio Ziparo, Francesco Cecconi and Claudia Giampietri. https://www.nature.com/articles/s41419-021-03957-5

Puma- and Caspase9-mediated apoptosis is dispensable for p53-driven neural crest-based developmental defects – Margot E. Bowen, Abigail S. Mulligan, Aryo Sorayya and Laura D. Attardi. https://www.nature.com/articles/s41418-021-00738-7


Necroptosis


A toolbox for imaging RIPK1, RIPK3, and MLKL in mouse and human cells – André L. Samson, Cheree Fitzgibbon, Komal M. Patel, Joanne M. Hildebrand, Lachlan W. Whitehead, Joel S. Rimes, Annette V. Jacobsen, Christopher R. Horne, Xavier J. Gavin, Samuel N. Young, Kelly L. Rogers, Edwin D. Hawkins and James M. Murphy. https://www.nature.com/articles/s41418-021-00742-x

E-type prostanoid receptor 4 drives resolution of intestinal inflammation by blocking epithelial necroptosis – Jay V. Patankar, Tanja M. Müller, Srinivas Kantham, Miguel Gonzalez Acera, Fabrizio Mascia, Kristina Scheibe, Mousumi Mahapatro, Christina Heichler, Yuqiang Yu, Wei Li, Barbara Ruder, Claudia Günther, Moritz Leppkes, Mano J. Mathew, Stefan Wirtz, Clemens Neufert, Anja A. Kühl, Jay Paquette, Kevan Jacobson, Raja Atreya, Sebastian Zundler, Markus F. Neurath, Robert N. Young and Christoph Becker. https://www.nature.com/articles/s41556-021-00708-8

CAMK2/CaMKII activates MLKL in short-term starvation to facilitate autophagic flux – Qionghui Zhan, Jaepyo Jeon, Ying Li, Yu Huang, Jian Xiong, Qiaochu Wang, Tian-Le Xu, Yong Li, Fu-Hai Ji, Guangwei Du and Michael X Zhu. https://www.tandfonline.com/doi/full/10.1080/15548627.2021.1954348

OTUB1 prevents lethal hepatocyte necroptosis through stabilization of c-IAP1 during murine liver inflammation – Josephin Koschel, Gopala Nishanth, Sissy Just, Kunjan Harit, Andrea Kröger, Martina Deckert, Michael Naumann & Dirk Schlüter. https://www.nature.com/articles/s41418-021-00752-9


Ferroptosis


Dysfunction of the key ferroptosis-surveilling systems hypersensitizes mice to tubular necrosis during acute kidney injury – Wulf Tonnus, Claudia Meyer, Christian Steinebach, Alexia Belavgeni, Anne von Mässenhausen, Nadia Zamora Gonzalez, Francesca Maremonti, Florian Gembardt, Nina Himmerkus, Markus Latk, Sophie Locke, Julian Marschner, Wenjun Li, Spencer Short, Sebastian Doll, Irina Ingold, Bettina Proneth, Christoph Daniel, Nazanin Kabgani, Rafael Kramann, Stephen Motika, Paul J. Hergenrother, Stefan R. Bornstein, Christian Hugo, Jan Ulrich Becker, Kerstin Amann, Hans-Joachim Anders, Daniel Kreisel, Derek Pratt, Michael Gütschow, Marcus Conrad and Andreas Linkermann. https://www.nature.com/articles/s41467-021-24712-6

Peroxisome-driven ether-linked phospholipids biosynthesis is essential for ferroptosis – Weiwei Cui, Dong Liu, Wei Gu and Bo Chu. https://www.nature.com/articles/s41418-021-00769-0

Obesity-Dependent Adipokine Chemerin Suppresses Fatty Acid Oxidation to Confer Ferroptosis Resistance – Sze Kiat Tan, Iqbal Mahmud, Flavia Fontanesi, Michelle Puchowicz, Chase K.A. Neumann, Anthony J. Griswold, Rutulkumar Patel, Marco Dispagna, Hamzah H. Ahmed, Mark L. Gonzalgo, J. Mark Brown, Timothy J. Garrett and Scott M. Welford. https://cancerdiscovery.aacrjournals.org/content/11/8/2072


Pyroptosis


RIPK1 activates distinct gasdermins in macrophages and neutrophils upon pathogen blockade of innate immune signaling – Kaiwen W. Chen, Benjamin Demarco, Saray Ramos, Rosalie Heilig, Michiel Goris, James P. Grayczyk, Charles-Antoine Assenmacher, Enrico Radaelli, Leonel D. Joannas, Jorge Henao-Mejia, Fabienne Tacchini-Cottier, Igor E. Brodsky, and Petr Broz. https://www.pnas.org/content/118/28/e2101189118.abstract

GSDME-mediated pyroptosis promotes inflammation and fibrosis in obstructive nephropathy – Yinshuang Li, Ying Yuan, Zhong-xing Huang, Hui Chen, Ruilong Lan, Zeng Wang, Kunmei Lai, Hong Chen, Zhimin Chen, Zhenhuan Zou, Hua-bin Ma, Hui-Yao Lan, Tak W. Mak and Yanfang Xu. https://www.nature.com/articles/s41418-021-00755-6


Miscellanous


Targeting multiple cell death pathways extends the shelf life and preserves the function of human and mouse neutrophils for transfusion – Yuping Fan , Yan Teng, Fabien Loison, Aiming Pang, Anongnard Kasorn, Xinqi Shao, Cunling Zhang, Qian Ren, Hongbo Yu, Yi Zheng, Jose A. Cancelas, John Manis, Li Chai, Shin-Young Park, Li Zhao, Yuanfu Xu, Sizhou Feng, Leslie E. Silberstein, Fengxia Ma, Hongbo R. Luo. https://stm.sciencemag.org/content/13/604/eabb1069

OAS1/RNase L executes RIG-I ligand–dependent tumor cell apoptosis – Daniel F. R. Boehmer , Simone Formisano, Carina C. de Oliveira Mann, Stephan A. Mueller, Michael Kluge, Philipp Metzger, Meino Rohlfs, Christine Hörth, Lorenz Kocheise, Stefan F. Lichtenthaler, Karl-Peter Hopfner, Stefan Endres, Simon Rothenfusser, Caroline C. Friedel, Peter Duewell, Max Schnurr, Lars M. Koenig. https://immunology.sciencemag.org/content/6/61/eabe2550

Plasma membrane permeabilization following cell death: many ways to dye! – Elke De Schutter, Benjamin Cappe, Bartosz Wiernicki, Peter Vandenabeele and Franck B. Riquet. https://www.nature.com/articles/s41420-021-00545-6


Reviews/comments


Molecular mechanisms of cell death in neurological diseases – Diane Moujalled, Andreas Strasser and Jeffrey R. Liddell. https://www.nature.com/articles/s41418-021-00814-y

Slow cell death helps tissue repair – Kim Baumann. https://www.nature.com/articles/s41580-021-00397-z

Targeting Bcl-2 for cancer therapy – Linlin Zhang, Zaiming Lu, Xiangxuan Zhao

https://www.sciencedirect.com/science/article/abs/pii/S0304419X21000664

Chemerin Tips the Scales in ccRCC to Evade Ferroptosis – Ed Reznik, Hui Jiang, and A. Ari Hakimi. https://cancerdiscovery.aacrjournals.org/content/11/8/1879


Cancer immunometabolism – EMBO Workshop

29 November – 01 December 2021 | Sitges, Barcelona, Spain – Hybrid conference

Organized by Cristina Muñoz Pinedo, Jean-Ehrland Ricci and Eric Eldering

https://meetings.embo.org/event/21-cancer

ApoList – June 2021


Efferocytosis and cell-cell effects


Collective ERK/Akt activity waves orchestrate epithelial homeostasis by driving apoptosis-induced survival – Paolo Armando Gagliardi, Maciej Dobrzyński, Marc-Antoine Jacques, Coralie Dessauges, Pascal Ender, Yannick Blum, Robert M. Hughes, Andrew R. Cohen, Olivier Pertz. https://www.cell.com/developmental-cell/fulltext/S1534-5807(21)00436-6

Robustness of epithelial sealing is an emerging property of local ERK feedback driven by cell elimination – Léo Valon, Anđela Davidović, Florence Levillayer, Alexis Villars, Mathilde Chouly, Fabiana Cerqueira-Campos, Romain Levayer. https://www.cell.com/developmental-cell/fulltext/S1534-5807(21)00435-4

Chemokines act as phosphatidylserine-bound “find-me” signals in apoptotic cell clearance – Sergio M. Pontejo, Philip M. Murphy. https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3001259

GPR34-mediated sensing of lysophosphatidylserine released by apoptotic neutrophils activates type 3 innate lymphoid cells to mediate tissue repair – Xiaqiong Wang, Juan Cai, Bolong Lin, Ming Ma, Ye Tao, Yubo Zhou, Li Bai, Wei Jiang, Rongbin Zhou. https://www.cell.com/immunity/fulltext/S1074-7613(21)00213-2

Efferocytosis by Paneth cells within the intestine – Laura S. Shankman, Samantha T. Fleury, W. Britt Evans, Kristen K. Penberthy, Sanja Arandjelovic, Richard S. Blumberg, Hervé Agaisse, Kodi S. Ravichandran. https://www.cell.com/current-biology/fulltext/S0960-9822(21)00428-0


Bcl-2 family proteins


Mitochondrial apoptotic priming is a key determinant of cell fate upon p53 restoration – Francisco J. Sánchez-Rivera, Jeremy Ryan, Yadira M. Soto-Feliciano, Mary Clare Beytagh, Lucius Xuan, David M. Feldser, Michael T. Hemann, Jesse Zamudio, Nadya Dimitrova, Anthony Letai, and Tyler Jacks. https://www.pnas.org/content/118/23/e2019740118.abstract?etoc

Stepwise activation of the pro-apoptotic protein Bid at mitochondrial membranes – Chien-Lun Hung, Hsin-Ho Chang, Su Wei Lee and Yun-Wei Chiang. https://www.nature.com/articles/s41418-020-00716-5

Pharmacological preconditioning protects from ischemia/reperfusion‐induced apoptosis by modulating Bcl‐xL expression through a ROS‐dependent mechanism – Romain Rozier, Rachel Paul, Blandine Madji Hounoum, Elodie Villa, Rana Mhaidly, Johanna Chiche, Els Verhoeyen, Sandrine Marchetti, Ashaina Vandenberghe, Marc Raucoules, Michel Carles, Jean-Ehrland Ricci. https://febs.onlinelibrary.wiley.com/doi/abs/10.1111/febs.15675

Metabolic perturbations sensitize triple-negative breast cancers to apoptosis induced by BH3 mimetics – Veerle W. Daniels , Jason J. Zoeller, Nick van Gastel, Kelley E. McQueeney, Salma Parvin, Danielle S. Potter, Geoffrey G. Fell, Vinícius G. Ferreira, Binyam Yilma, Rajat Gupta, Johan Spetz, Patrick D. Bhola, Jennifer E. Endress, Isaac S. Harris, Emanuel Carrilho, Kristopher A. Sarosiek, David T. Scadden, Joan S. Brugge, Anthony Letai. https://stke.sciencemag.org/content/14/686/eabc7405

Puma, noxa, p53, and p63 differentially mediate stress pathway induced apoptosis [in zebrafish] – Jun Wang, Holly R. Thomas, Zhang Li, Nan Cher (Florence) Yeo, Hannah E. Scott, Nghi Dang, Mohammed Iqbal Hossain, Shaida A. Andrabi and John M. Parant. https://www.nature.com/articles/s41419-021-03902-6


Death receptors


Hexavalent TRAIL Fusion Protein Eftozanermin Alfa Optimally Clusters Apoptosis-Inducing TRAIL Receptors to Induce On-Target Antitumor Activity in Solid Tumors – Darren C. Phillips, Fritz G. Buchanan, Dong Cheng, Larry R. Solomon, Yu Xiao, John Xue, Stephen K. Tahir, Morey L. Smith, Haichao Zhang, Deborah Widomski, Vivek C. Abraham, Nan Xu, Zhihong Liu, Li Zhou, Enrico DiGiammarino, Xin Lu, Nandini Rudra-Ganguly, Bruce Trela and Susan E. Morgan-Lappe. https://cancerres.aacrjournals.org/content/81/12/3402

Marizomib sensitizes primary glioma cells to apoptosis induced by a latest-generation TRAIL receptor agonist – Chiara Boccellato, Emily Kolbe, Nathalie Peters, Viktorija Juric, Gavin Fullstone, Maïté Verreault, Ahmed Idbaih, Martine L. M. Lamfers, Brona M. Murphy and Markus Rehm. https://www.nature.com/articles/s41419-021-03927-x

OPG/TRAIL ratio as a predictive biomarker of mortality in patients with type A acute aortic dissection – Jie Lu, Ping Li, Ke Ma, Yang Li, Hui Yuan, Junming Zhu, Weixun Duan, Jingsong Ou, Yonghong Huang, Long Wu, Xueliang Pan, Hui Zhang, Jie Du and Yulin Li. https://www.nature.com/articles/s41467-021-23787-5


Caspases


Caspase inhibition prolongs inflammation by promoting a signaling complex with activated RIPK1 – Xinyue Huang, Shuixia Tan, Yanxia Li, Shuangyi Cao, Xingyan Li, Heling Pan, Bing Shan, Lihui Qian, Junying Yuan. https://rupress.org/jcb/article-abstract/220/6/e202007127/212035

Rictor, an essential component of mTOR complex 2, undergoes caspase-mediated cleavage during apoptosis induced by multiple stimuli – Liqun Zhao, Lei Zhu, You-Take Oh, Guoqing Qian, Zhen Chen, Shi-Yong Sun. https://link.springer.com/article/10.1007/s10495-021-01676-y


Necroptosis


Ubiquitylation of MLKL at lysine 219 positively regulates necroptosis-induced tissue injury and pathogen clearance – Laura Ramos Garcia, Tencho Tenev, Richard Newman, Rachel O. Haich, Gianmaria Liccardi, Sidonie Wicky John, Alessandro Annibaldi, Lu Yu, Mercedes Pardo, Samuel N. Young, Cheree Fitzgibbon, Winnie Fernando, Naomi Guppy, Hyojin Kim, Lung-Yu Liang, Isabelle S. Lucet, Andrew Kueh, Ioannis Roxanis, Patrycja Gazinska, Martin Sims, Tomoko Smyth, George Ward, John Bertin, Allison M. Beal, Brad Geddes, Jyoti S. Choudhary, James M. Murphy, K. Aurelia Ball, Jason W. Upton and Pascal Meier. https://www.nature.com/articles/s41467-021-23474-5

The MLKL kinase-like domain dimerization is an indispensable step of mammalian MLKL activation in necroptosis signaling – Yu Zhang, Jia Liu, Dandan Yu, Xinxin Zhu, Xiaoyan Liu, Jun Liao, Sheng Li and Huayi Wang. https://www.nature.com/articles/s41419-021-03859-6

NF-κB inhibition in keratinocytes causes RIPK1-mediated necroptosis and skin inflammation – Snehlata Kumari, Trieu-My Van, Daniela Preukschat, Hannah Schuenke, Marijana Basic, André Bleich, Ulf Klein and Manolis Pasparakis. https://www.life-science-alliance.org/content/4/6/e202000956.abstract


Pyroptosis


The lysosomal Rag-Ragulator complex licenses RIPK1– and caspase-8–mediated pyroptosis by Yersinia – Zengzhang Zheng, Wanyan Deng, Yang Bai, Rui Miao, Shenglin Mei, Zhibin Zhang, Youdong Pan, Yi Wang, Rui Min, Fan Deng, Zeyu Wu, Wu Li, Pengcheng Chen, Tianchi Ma, Xiwen Lou, Judy Lieberman, Xing Liu. https://science.sciencemag.org/content/372/6549/eabg0269

Gasdermin-E-mediated pyroptosis participates in the pathogenesis of Crohn’s disease by promoting intestinal inflammation – Gao Tan, Chongyang Huang, Jiaye Chen, Bingxia Chen, Fachao Zhi. https://www.cell.com/cell-reports/fulltext/S2211-1247(21)00632-X

Ischemia reperfusion injury induces pyroptosis and mediates injury in steatotic liver thorough Caspase 1 activation – Vasantha L. Kolachala, Chrissy Lopez, Ming Shen, Dmitry Shayakhmetov, Nitika Arora Gupta. https://link.springer.com/article/10.1007/s10495-021-01673-1


Ferroptosis


Oxygenated phosphatidylethanolamine navigates phagocytosis of ferroptotic cells by interacting with TLR2 – Xiang Luo, Hai-Biao Gong, Hua-Ying Gao, Yan-Ping Wu, Wan-Yang Sun, Zheng-Qiu Li, Guan Wang, Bo Liu, Lei Liang, Hiroshi Kurihara, Wen-Jun Duan, Yi-Fang Li and Rong-Rong He. https://www.nature.com/articles/s41418-020-00719-2


Cell death and immunity


Functional heterogeneity of cytotoxic T cells and tumor resistance to cytotoxic hits limit anti‐tumor activity in vivo – Roxana Khazen, Marine Cazaux, Fabrice Lemaître, Beatrice Corre, Zacarias Garcia, Philippe Bousso. https://www.embopress.org/doi/abs/10.15252/embj.2020106658

Pathogenic ubiquitination of GSDMB inhibits NK cell bactericidal functions – Justin M. Hansen, Maarten F. de Jong, Qi Wu, Li-Shu Zhang, David B. Heisler, Laura T. Alto, Neal M. Alto. https://www.cell.com/cell/fulltext/S0092-8674(21)00571-7

TAK1 inhibition elicits mitochondrial ROS to block intracellular bacterial colonization – Wilfred López-Pérez, Kazuhito Sai, Yosuke Sakamachi, Cameron Parsons, Sophia Kathariou, and Jun Ninomiya-Tsuji. https://www.pnas.org/content/118/25/e2023647118.abstract?etoc


Miscellanous


A unique mode of keratinocyte death requires intracellular acidification – Takeshi Matsui, Nanako Kadono-Maekubo, Yoshiro Suzuki, Yuki Furuichi, Keiichiro Shiraga, Hiroyuki Sasaki, Azusa Ishida, Sonoko Takahashi, Takaharu Okada, Kiminori Toyooka, Jafar Sharif, Takaya Abe, Hiroshi Kiyonari, Makoto Tominaga, Atsushi Miyawaki, Masayuki Amagai. https://www.pnas.org/content/118/17/e2020722118

Targeting highly pathogenic coronavirus-induced apoptosis reduces viral pathogenesis and disease severity – Hin Chu , Huiping Shuai, Yuxin Hou, Xi Zhang, Lei Wen, Xiner Huang, Bingjie Hu, Dong Yang, Yixin Wang, Chaemin Yoon, Bosco Ho-Yin Wong, Cun Li, Xiaoyu Zhao, Vincent Kwok-Man Poon, Jian-Piao Cai, Kenneth Kak-Yuen Wong, Man-Lung Yeung, Jie Zhou, Rex Kwok-Him Au-Yeung, Shuofeng Yuan, Dong-Yan Jin, Kin-Hang Kok, Stanley Perlman, Jasper Fuk-Woo Chan, Kwok-Yung Yuen. https://advances.sciencemag.org/content/7/25/eabf8577


Reviews


Too much death can kill you: inhibiting intrinsic apoptosis to treat disease – Kaiming Li, Mark F van Delft, Grant Dewson. https://www.embopress.org/doi/abs/10.15252/embj.2020107341

Great balls of fire: activation and signalling of inflammatory caspases – Georgia Bateman, Benjamin Hill, Ryan Knight, Dave Boucher. https://portlandpress.com/biochemsoctrans/article/doi/10.1042/BST20200986/228851

MLKL in cancer: more than a necroptosis regulator – Sofie Martens, Jolien Bridelance, Ria Roelandt, Peter Vandenabeele and Nozomi Takahashi. https://www.nature.com/articles/s41418-021-00785-0

NET formation – mechanisms and how they relate to other cell death pathways – Thibault Rosazza, Jordan Warner, Gabriel Sollberger. https://febs.onlinelibrary.wiley.com/doi/full/10.1111/febs.15589

Putting the brakes on phagocytosis: “don’t‐eat‐me” signaling in physiology and disease – Shannon M Kelley, Kodi S Ravichandran. https://www.embopress.org/doi/abs/10.15252/embr.202152564

Ferroptosis in infection, inflammation, and immunity – Xin Chen; Rui Kang; Guido Kroemer; Daolin Tang. https://rupress.org/jem/article-abstract/218/6/e20210518/212093

The role of P53 up-regulated modulator of apoptosis (PUMA) in ovarian development, cardiovascular and neurodegenerative diseases – Mei Li. https://link.springer.com/article/10.1007/s10495-021-01667-z


Comments


Death in the Fas, ELANE – Anthony Letai. https://www.cell.com/cell/fulltext/S0092-8674(21)00654-1

Functional cell death, corneoptosis, requires temporally controlled intracellular acidification – Jessica L. Moore and Valentina Greco. https://www.pnas.org/content/118/22/e2106633118

Distributing apoptosis protects epithelia – Annalisa M. VanHook. https://stke.sciencemag.org/content/14/689/eabk1364

ApoList – May 2021


Bcl-2 family proteins


Regulation of Bcl-XL by non-canonical NF-κB in the context of CD40-induced drug resistance in CLL – Marco Haselager, Rachel Thijssen, Christopher West, Louise Young, Roel Van Kampen, Elaine Willmore, Simon Mackay, Arnon Kater and Eric Eldering. https://www.nature.com/articles/s41418-020-00692-w

CRISPR screens identify a novel combination treatment targeting BCL-XL and WNT signaling for KRAS/BRAF-mutated colorectal cancers – Hae Rim Jung, Yumi Oh, Deukchae Na, Seoyeon Min, Jinjoo Kang, Dongjun Jang, Seungjae Shin, Jiwon Kim, Sang Eun Lee, Eui Man Jeong, Joon Yong An, Chang Ohk Sung, Won-Suk Lee, Charles Lee and Sung-Yup Cho. https://www.nature.com/articles/s41388-021-01777-7

A novel BH3-mimetic, AZD0466, targeting BCL-XL and BCL-2 is effective in pre-clinical models of malignant pleural mesothelioma – Surein Arulananda, Megan O’Brien, Marco Evangelista, Laura J. Jenkins, Ashleigh R. Poh, Marzena Walkiewicz, Trishe Leong, John M. Mariadason, Jonathan Cebon, Srividya B. Balachander, Justin R. Cidado, Erinna F. Lee, Thomas John and Walter D. Fairlie. https://www.nature.com/articles/s41420-021-00505-0

Endogenous Retroelement Activation by Epigenetic Therapy Reverses the Warburg Effect and Elicits Mitochondrial-Mediated Cancer Cell Death – Vicente Fresquet, Maria J. Garcia-Barchino, Marta Larrayoz, Jon Celay, Carmen Vicente, Marta Fernandez-Galilea, Maria J. Larrayoz, Maria J. Calasanz, Carlos Panizo, Alexandra Junza, Jiahuai Han, Celia Prior, Puri Fortes, Ruben Pio, Julen Oyarzabal, Alvaro Martinez-Baztan, Bruno Paiva, Maria J. Moreno-Aliaga, Maria D. Odero, Xabier Agirre, Oscar Yanes, Felipe Prosper and Jose A. Martinez-Climent. https://cancerdiscovery.aacrjournals.org/content/11/5/1268

Antiapoptotic Bcl-2 family proteins BCL-xL and MCL-1 integrate neural progenitor survival and proliferation during postnatal cerebellar neurogenesis – Katherine A. Veleta, Abigail H. Cleveland, Benjamin R. Babcock, You-Wen He, Duhyeong Hwang, Marina Sokolsky-Papkov and Timothy R. Gershon. https://www.nature.com/articles/s41418-020-00687-7

BAD regulates mammary gland morphogenesis by 4E-BP1-mediated control of localized translation in mouse and human models – John Maringa Githaka, Namita Tripathi, Raven Kirschenman, Namrata Patel, Vrajesh Pandya, David A. Kramer, Rachel Montpetit, Lin Fu Zhu, Nahum Sonenberg, Richard P. Fahlman, Nika N. Danial, D. Alan Underhill and Ing Swie Goping. https://www.nature.com/articles/s41467-021-23269-8


Death receptors


TNF controls a speed-accuracy tradeoff in the cell death decision to restrict viral spread – Jennifer Oyler-Yaniv, Alon Oyler-Yaniv, Evan Maltz and Roy Wollman. https://www.nature.com/articles/s41467-021-23195-9

Generation of TRAIL-resistant cell line models reveals distinct adaptive mechanisms for acquired resistance and re-sensitization – Ahmet Cingöz, Ezgi Ozyerli-Goknar, Tunc Morova, Fidan Seker-Polat, Myvizhi Esai Selvan, Zeynep Hülya Gümüş, Deepak Bhere, Khalid Shah, Ihsan Solaroglu and Tugba Bagci-Onder. https://www.nature.com/articles/s41388-021-01697-6

CDK2-Mediated Upregulation of TNFα as a Mechanism of Selective Cytotoxicity in Acute Leukemia – Husheng Ding, Nicole D. Vincelette, Cordelia D. McGehee, Mira A. Kohorst, Brian D. Koh, Annapoorna Venkatachalam, X. Wei Meng, Paula A. Schneider, Karen S. Flatten, Kevin L. Peterson, Cristina Correia, Sun-Hee Lee, Mrinal Patnaik, Jonathan A. Webster, Gabriel Ghiaur, B. Douglas Smith, Judith E. Karp, Keith W. Pratz, Hu Li, Larry M. Karnitz and Scott H. Kaufmann. https://cancerres.aacrjournals.org/content/81/10/2666


Caspases and IAPs


Evaluation of the effects of phosphorylation of synthetic peptide substrates on their cleavage by caspase-3 and -7 – Izabela Maluch, Justyna Grzymska, Scott Snipas, Guy S Salvesen, Marcin Drag. https://portlandpress.com/biochemj/article/doi/10.1042/BCJ20210255/228758/

Moderate DNA hypomethylation suppresses intestinal tumorigenesis by promoting caspase-3 expression and apoptosis – Xiaoya Duan, Yuanyong Huang, Xiaoxing Chen, Wencai Wang, Jiwei Chen, Jialun Li, Wei Yang, Jiwen Li, Qihan Wu and Jiemin Wong. https://www.nature.com/articles/s41389-021-00328-9

cIAP1/2 antagonism eliminates MHC class I–negative tumors through T cell–dependent reprogramming of mononuclear phagocytes – Kevin Roehle , Li Qiang, Katherine S. Ventre, Daniel Heid, Lestat R. Ali, Patrick Lenehan, Max Heckler, Stephanie J. Crowley, Courtney T. Stump, Gabrielle Ro, Anže Godicelj, Aladdin M. Bhuiyan, Annan Yang, Maria Quiles del Rey, Tamara Biary, Adrienne M. Luoma, Patrick T. Bruck, Jana F. Tegethoff, Svenja L. Nopper, Jinyang Li, Katelyn T. Byrne, Marc Pelletier, Kai W. Wucherpfennig, Ben Z. Stanger, James J. Akin, Joseph D. Mancias, Judith Agudo, Michael Dougan, Stephanie K. Dougan. https://stm.sciencemag.org/content/13/594/eabf5058


Necroptosis


ZBP1 not RIPK1 mediates tumor necroptosis in breast cancer – Jin Young Baik, Zhaoshan Liu, Delong Jiao, Hyung-Joon Kwon, Jiong Yan, Chamila Kadigamuwa, Moran Choe, Ross Lake, Michael Kruhlak, Mayank Tandon, Zhenyu Cai, Swati Choksi and Zheng-gang Liu. https://www.nature.com/articles/s41467-021-23004-3

Necroptosis is dispensable for the development of inflammation-associated or sporadic colon cancer in mice – Silvia Alvarez-Diaz, Adele Preaudet, Andre L. Samson, Paul M. Nguyen, Ka Yee Fung, Alexandra L. Garnham, Warren S. Alexander, Andreas Strasser, Matthias Ernst, Tracy L. Putoczki and James M. Murphy. https://www.nature.com/articles/s41418-020-00673-z

RIPK1 activation mediates neuroinflammation and disease progression in multiple sclerosis – Matija Zelic, Fabrizio Pontarelli, Lisa Woodworth, Cheng Zhu, Amy Mahan, Yi Ren, Michael LaMorte, Ross Gruber, Aislinn Keane, Pequita Loring, Lilu Guo, Tai-he Xia, Boyao Zhang, Pontus Orning, Egil Lien, Alexei Degterev, Timothy Hammond, Dimitry Ofengeim. https://www.cell.com/cell-reports/fulltext/S2211-1247(21)00446-0

Primidone blocks RIPK1-driven cell death and inflammation – Theresa Riebeling, Kunzah Jamal, Rebecca Wilson, Benedikt Kolbrink, Friedrich Alexander von Samson-Himmelstjerna, Caroline Moerke, Laura Ramos Garcia, Eileen Dahlke, Friederike Michels, Fred Lühder, Domagoj Schunk, Philipp Doldi, Bartosz Tyczynski, Andreas Kribben, Charlotte Flüh, Franziska Theilig, Ulrich Kunzendorf, Pascal Meier and Stefan Krautwald. https://www.nature.com/articles/s41418-020-00690-y


Ferroptosis


Ferroptotic pores induce Ca2+ fluxes and ESCRT-III activation to modulate cell death kinetics – Lohans Pedrera, Rafael A. Espiritu, Uris Ros, Josephine Weber, Anja Schmitt, Jenny Stroh, Stephan Hailfinger, Silvia von Karstedt and Ana J. García-Sáez. https://www.nature.com/articles/s41418-020-00691-x

CD36-mediated ferroptosis dampens intratumoral CD8+ T cell effector function and impairs their antitumor ability – Xingzhe Ma, Liuling Xiao, Lintao Liu, Lingqun Ye, Pan Su, Enguang Bi, Qiang Wang, Maojie Yang, Jianfei Qian, Qing Yi. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(21)00071-1

DHODH-mediated ferroptosis defence is a targetable vulnerability in cancer – Chao Mao, Xiaoguang Liu, Yilei Zhang, Guang Lei, Yuelong Yan, Hyemin Lee, Pranavi Koppula, Shiqi Wu, Li Zhuang, Bingliang Fang, Masha V. Poyurovsky, Kellen Olszewski and Boyi Gan. https://www.nature.com/articles/s41586-021-03539-7

The mitochondrial Ca2+ uptake regulator, MICU1, is involved in cold stress‐induced ferroptosis – Toshitaka Nakamura, Motoyuki Ogawa, Kazuki Kojima, Saki Takayanagi, Shunya Ishihara, Kazuki Hattori, Isao Naguro, Hidenori Ichijo. https://www.embopress.org/doi/abs/10.15252/embr.202051532

Ferroptosis as a mechanism to mediate p53 function in tumor radiosensitivity – Guang Lei, Yilei Zhang, Ting Hong, Xudong Zhang, Xiaoguang Liu, Chao Mao, Yuelong Yan, Pranavi Koppula, Weijie Cheng, Anil K. Sood, Jinsong Liu and Boyi Gan. https://www.nature.com/articles/s41388-021-01790-w

Loss of ferroportin induces memory impairment by promoting ferroptosis in Alzheimer’s disease – Wen-Dai Bao, Pei Pang, Xiao-Ting Zhou, Fan Hu, Wan Xiong, Kai Chen, Jing Wang, Fudi Wang, Dong Xie, Ya-Zhuo Hu, Zhi-Tao Han, Hong-Hong Zhang, Wang-Xia Wang, Peter T. Nelson, Jian-Guo Chen, Youming Lu, Heng-Ye Man, Dan Liu and Ling-Qiang Zhu. https://www.nature.com/articles/s41418-020-00685-9


Efferocytosis, entosis etc


Replication stress promotes cell elimination by extrusion – Vivek K. Dwivedi, Carlos Pardo-Pastor, Rita Droste, Ji Na Kong, Nolan Tucker, Daniel P. Denning, Jody Rosenblatt and H. Robert Horvitz. https://www.nature.com/articles/s41586-021-03526-y

DNase II mediates a parthanatos-like developmental cell death pathway in Drosophila primordial germ cells – Lama Tarayrah-Ibraheim, Elital Chass Maurice, Guy Hadary, Sharon Ben-Hur, Alina Kolpakova, Tslil Braun, Yoav Peleg, Keren Yacobi-Sharon and Eli Arama. https://www.nature.com/articles/s41467-021-22622-1

PI3KC3 complex subunit NRBF2 is required for apoptotic cell clearance to restrict intestinal inflammation – Ming-Yue Wu, Le Liu, Er-Jin Wang, Hai-Tao Xiao, Cui-Zan Cai, Jing Wang, Huanxing Su, Yitao Wang, Jieqiong Tan, Zhuohua Zhang, Juan Wang, Maojing Yao, De-Fang Ouyang, Zhenyu Yue, Min Li, Ye Chen, Zhao-Xiang Bian and Jia-Hong Lu. https://www.tandfonline.com/doi/abs/10.1080/15548627.2020.1741332


Miscellanous


BNIP3 promotes HIF‐1α‐driven melanoma growth by curbing intracellular iron homeostasis – Mónica Vara-Pérez, Matteo Rossi, Chris Van den Haute, Hannelore Maes, Maria Livia Sassano, Vivek Venkataramani, Bernhard Michalke, Erminia Romano, Kristine Rillaerts, Abhishek D Garg, Corentin Schepkens, Francesca M Bosisio, Jasper Wouters, Ana Isabel Oliveira, Peter Vangheluwe, Wim Annaert, Johannes V Swinnen, Jean Marie Colet, Joost J van den Oord, Sarah-Maria Fendt, Massimiliano Mazzone, Patrizia Agostinis. https://www.embopress.org/doi/full/10.15252/embj.2020106214


Reviews


Punching Holes in Cellular Membranes: Biology and Evolution of Gasdermins – Elke De Schutter, Ria Roelandt, Franck B. Riquet, Guy Van Camp, Andy Wullaert, Peter Vandenabeele. https://www.cell.com/trends/cell-biology/fulltext/S0962-8924(21)00050-7

Mechanistic connections between mitochondrial biology and regulated cell death – Jerry Edward Chipuk, Jarvier N. Mohammed, Jesse D. Gelles, Yiyang Chen. https://www.cell.com/developmental-cell/fulltext/S1534-5807(21)00308-7

Open questions on the mitochondrial unfolded protein response – Friederike‐Nora Vögtle. https://febs.onlinelibrary.wiley.com/doi/full/10.1111/febs.15569

The importance of transmembrane domain interactions in the viral control of apoptosis – Gerard Duart, Ismael Mingarro and Luis Martinez-Gil. https://www.tandfonline.com/doi/full/10.1080/23723556.2021.1911290

ApoList – April 2021


Bcl-2 family proteins


Structural insight into the molecular mechanism of p53-mediated mitochondrial apoptosis – Hudie Wei, Lingzhi Qu, Shuyan Dai, Yun Li, Haolan Wang, Yilu Feng, Xiaojuan Chen, Longying Jiang, Ming Guo, Jun Li, Zhuchu Chen, Lin Chen, Ye Zhang and Yongheng Chen. https://www.nature.com/articles/s41467-021-22655-6

The spleen as a sanctuary site for residual leukemic cells following ABT-199 monotherapy in ETP-ALL – Alessandra Di Grande, Sofie Peirs, Paul D. Donovan, Maaike Van Trimpont, Julie Morscio, Beatrice Lintermans, Lindy Reunes, Niels Vandamme, Steven Goossens, Hien Anh Nguyen, Arnon Lavie, Richard B. Lock, Jochen H. M. Prehn, Pieter Van Vlierberghe, Triona Ní Chonghaile. https://ashpublications.org/bloodadvances/article/5/7/1963/475682

Pathological angiogenesis in retinopathy engages cellular senescence and is amenable to therapeutic elimination via BCL-xL inhibition – Sergio Crespo-Garcia, Pamela R. Tsuruda, Agnieszka Dejda, Rathi D. Ryan, Frederik Fournier, Shawnta Y. Chaney, Frederique Pilon, Taner Dogan, Gael Cagnone, Priyanka Patel, Manuel Buscarlet, Sonali Dasgupta, Gabrielle Girouard, Surabhi R. Rao, Ariel M. Wilson, Robert O’Brien, Rachel Juneau, Vera Guber, Alexandre Dubrac, Christian Beausejour, Scott Armstrong, Frederick A. Mallette, Christopher B. Yohn, Jean-Sebastien Joyal, Dan Marquess, Pedro J. Beltran, Przemyslaw Sapieha. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(21)00011-5

Identification of a novel Bax–Cdk1 signalling complex that links activation of the mitotic checkpoint to apoptosis – Omeed Darweesh, Eman Al-Shehri, Hugo Falquez, Joachim Lauterwasser, Frank Edlich, Rajnikant Patel. https://journals.biologists.com/jcs/article/134/8/jcs244152/237811


RIPK1 / death receptors


Genetic inactivation of RIP1 kinase activity in rats protects against ischemic brain injury – Kimberly Stark, Tatiana Goncharov, Eugene Varfolomeev, Luke Xie, Hai Ngu, Ivan Peng, Keith R. Anderson, Erik Verschueren, Meena Choi, Donald S. Kirkpatrick, Amy Easton, Joshua D. Webster, Brent S. McKenzie, Domagoj Vucic and Baris Bingol. https://www.nature.com/articles/s41419-021-03651-6

RIP1 kinase activity promotes steatohepatitis through mediating cell death and inflammation in macrophages – Liang Tao, Yuguo Yi, Yuxin Chen, Haibing Zhang, Pontus Orning, Egil Lien, Jiapeng Jie, Weigao Zhang, Qian Xu, Yang Li, Zhao Ding, Chao Wu, Qiurong Ding, Junsong Wang, Jianfa Zhang and Dan Weng. https://www.nature.com/articles/s41418-020-00668-w

Splicing reprogramming of TRAIL/DISC-components sensitizes lung cancer cells to TRAIL-mediated apoptosis – Oliver H. Voss, Daniel Arango, Justin C. Tossey, Miguel A. Villalona Calero and Andrea I. Doseff. https://www.nature.com/articles/s41419-021-03567-1


Necroptosis


Conformational interconversion of MLKL and disengagement from RIPK3 precede cell death by necroptosis – Sarah E. Garnish, Yanxiang Meng, Akiko Koide, Jarrod J. Sandow, Eric Denbaum, Annette V. Jacobsen, Wayland Yeung, Andre L. Samson, Christopher R. Horne, Cheree Fitzgibbon, Samuel N. Young, Phoebe P. C. Smith, Andrew I. Webb, Emma J. Petrie, Joanne M. Hildebrand, Natarajan Kannan, Peter E. Czabotar, Shohei Koide and James M. Murphy. https://www.nature.com/articles/s41467-021-22400-z

A family harboring an MLKL loss of function variant implicates impaired necroptosis in diabetes – Joanne M. Hildebrand, Bernice Lo, Sara Tomei, Valentina Mattei, Samuel N. Young, Cheree Fitzgibbon, James M. Murphy and Abeer Fadda. https://www.nature.com/articles/s41419-021-03636-5

The structure of a minimum amyloid fibril core formed by necroptosis-mediating RHIM of human RIPK3 – Xialian Wu, Yeyang Ma, Kun Zhao, Jing Zhang, Yunpeng Sun, Yichen Li, Xingqi Dong, Hong Hu, Jing Liu, Jian Wang, Xia Zhang, Bing Li, Huayi Wang, Dan Li, Bo Sun, Junxia Lu, and Cong Liu. https://www.pnas.org/content/118/14/e2022933118.abstract?etoc


Pyroptosis


Gasdermin D pore structure reveals preferential release of mature interleukin-1 – Shiyu Xia, Zhibin Zhang, Venkat Giri Magupalli, Juan Lorenzo Pablo, Ying Dong, Setu M. Vora, Longfei Wang, Tian-Min Fu, Matthew P. Jacobson, Anna Greka, Judy Lieberman, Jianbin Ruan and Hao Wu. https://www.nature.com/articles/s41586-021-03478-3

Gasdermin E permits interleukin-1 beta release in distinct sublytic and pyroptotic phases – Bowen Zhou, Derek W. Abbott. https://www.cell.com/cell-reports/fulltext/S2211-1247(21)00312-0


Ferroptosis


Ferroptosis response segregates small cell lung cancer (SCLC) neuroendocrine subtypes – Christina M. Bebber, Emily S. Thomas, Jenny Stroh, Zhiyi Chen, Ariadne Androulidaki, Anna Schmitt, Michaela N. Höhne, Lukas Stüker, Cleidson de Pádua Alves, Armin Khonsari, Marcel A. Dammert, Fatma Parmaksiz, Hannah L. Tumbrink, Filippo Beleggia, Martin L. Sos, Jan Riemer, Julie George, Susanne Brodesser, Roman K. Thomas, H. Christian Reinhardt and Silvia von Karstedt. https://www.nature.com/articles/s41467-021-22336-4

Mitochondrial DNA stress triggers autophagy-dependent ferroptotic death – Changfeng Li, Ying Zhang, Jiao Liu, Rui Kang, Daniel J. Klionsky and Daolin Tang. https://www.tandfonline.com/doi/abs/10.1080/15548627.2020.1739447

Ferroptotic cell death triggered by conjugated linolenic acids is mediated by ACSL1 – Alexander Beatty, Tanu Singh, Yulia Y. Tyurina, Vladimir A. Tyurin, Svetlana Samovich, Emmanuelle Nicolas, Kristen Maslar, Yan Zhou, Kathy Q. Cai, Yinfei Tan, Sebastian Doll, Marcus Conrad, Aravind Subramanian, Hülya Bayır, Valerian E. Kagan, Ulrike Rennefahrt and Jeffrey R. Peterson. https://www.nature.com/articles/s41467-021-22471-y

Branched-chain amino acid aminotransferase 2 regulates ferroptotic cell death in cancer cells – Kang Wang, Zhengyang Zhang, Hsiang-i Tsai, Yanfang Liu, Jie Gao, Ming Wang, Lian Song, Xiongfeng Cao, Zhanxue Xu, Hongbo Chen, Aihua Gong, Dongqing Wang, Fang Cheng and Haitao Zhu. https://www.nature.com/articles/s41418-020-00644-4


Miscellanous


Apoptotic body-mediated intercellular delivery for enhanced drug penetration and whole tumor destruction – Dongyang Zhao, Wenhui Tao, Songhao Li, Yao Chen, Yinghua Sun, Zhonggui He, Bingjun Sun, Jin Sun. https://advances.sciencemag.org/content/7/16/eabg0880

Therapeutic efficiency of the APAF‐1 antagonist LPT99 in a rat model of cisplatin‐induced hearing loss – Silvia Murillo‐Cuesta,  Adelaida M Celaya,  Blanca Cervantes,  Jose M Bermúdez‐Muñoz,  Lourdes Rodríguez‐de la Rosa,  Julio Contreras,  Isabel Sánchez‐Pérez,  and Isabel Varela‐Nieto. https://onlinelibrary.wiley.com/doi/10.1002/ctm2.363

Oxylipin biosynthesis reinforces cellular senescence and allows detection of senolysis – Christopher D. Wiley, Rishi Sharma, Sonnet S. Davis, Marco Demaria, Arvind Ramanathan, Judith Campisi. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(21)00115-7


Reviews


Phagocytic clearance of apoptotic, necrotic, necroptotic and pyroptotic cells – Georgia K. Atkin-Smith. https://portlandpress.com/biochemsoctrans/article/doi/10.1042/BST20200696/228277

Autophagy in tumour immunity and therapy – Houjun Xia, Douglas R. Green and Weiping Zou. https://www.nature.com/articles/s41568-021-00344-2

Cellular degradation systems in ferroptosis – Xin Chen, Chunhua Yu, Rui Kang, Guido Kroemer and Daolin Tang. https://www.nature.com/articles/s41418-020-00728-1

Assembling the right type of switch: Protein condensation to signal cell death – Marta Badia, Benedetta Bolognesi. https://www.sciencedirect.com/science/article/pii/S0955067420301757


Comments


Targeting MCL1 to induce mitophagy is a potential therapeutic strategy for Alzheimer disease – Xufeng Cen, Xiaoyan Xu and Hongguang Xia. https://www.tandfonline.com/doi/full/10.1080/15548627.2020.1860542

Non‐lethal message from the Holy Land: The first international conference on nonapoptotic roles of apoptotic proteins – Eli Arama, Luis Alberto Baena‐Lopez, Howard O. Fearnhead. https://febs.onlinelibrary.wiley.com/doi/full/10.1111/febs.15547

ApoList – March 2021

 


Fas and Fas Ligand


A Critical Role for Fas-Mediated Off-Target Tumor Killing in T-cell Immunotherapy – Ranjan Upadhyay, Jonathan A. Boiarsky, Gvantsa Pantsulaia, Judit Svensson-Arvelund, Matthew J. Lin, Aleksandra Wroblewska, Sherry Bhalla, Nathalie Scholler, Adrian Bot, John M. Rossi, Norah Sadek, Samir Parekh, Alessandro Lagana, Alessia Baccarini, Miriam Merad, Brian D. Brown and Joshua D. Brody. https://cancerdiscovery.aacrjournals.org/content/11/3/599

Compromised counterselection by FAS creates an aggressive subtype of germinal center lymphoma – Raud Razzaghi; Shreya Agarwal; Nikita Kotlov; Olga Plotnikova; Krystle Nomie; Da Wei Huang; George W. Wrigh ; Grace A. Smith; Moyi Li; Katsuyoshi Takata; Maryam Yamadi; Chen Yao; John J. O’Shea; James D. Phelan; Stefania Pittaluga; David W. Scott; Jagan R. Muppidi. https://rupress.org/jem/article-abstract/218/3/e20201173/211563

Post-injury immunosuppression and secondary infections are caused by an AIM2 inflammasome-driven signaling cascade [FasL in myeloid cells] – Stefan Roth, Jiayu Cao, Vikramjeet Singh, Steffen Tiedt, Gabriel Hundeshagen, Ting Li, Julia D. Boehme, Dhruv Chauhan, Jie Zhu, Alessio Ricci, Oliver Gorka, Yaw Asare, Jun Yang, Mary S. Lopez, Markus Rehberg, Dunja Bruder, Shengxiang Zhang, Olaf Groß, Martin Dichgans, Veit Hornung, Arthur Liesz. https://www.cell.com/immunity/fulltext/S1074-7613(21)00070-4

Liver metastasis restrains immunotherapy efficacy via macrophage-mediated T cell elimination – Jiali Yu, Michael D. Green, […]Weiping Zou. https://www.nature.com/articles/s41591-020-1131-x


RIPK1


Impaired RIPK1 ubiquitination sensitizes mice to TNF toxicity and inflammatory cell death – Matthias Kist, László G. Kőműves, Tatiana Goncharov, Debra L. Dugger, Charles Yu, Merone Roose-Girma, Kim Newton, Joshua D. Webster and Domagoj Vucic. https://www.nature.com/articles/s41418-020-00629-3

JNK signaling prevents biliary cyst formation through a CASPASE-8–dependent function of RIPK1 during aging – Katrin Müller, Hanna Honcharova-Biletska, Christiane Koppe, Michèle Egger, Lap Kwan Chan, Anne T. Schneider, Lena Küsgens, Friederike Böhm, Yannick Boege, Marc E. Healy, Johannes Schmitt, Sarah Comtesse, Mirco Castoldi, Christian Preisinger, Marta Szydlowska, Enrico Focaccia, Nadine T. Gaisa, Sven H. Loosen, Simone Jörs, Frank Tacke, Christoph Roderburg, Verena Keitel, Johannes G. Bode, Peter Boor, Roger J. Davis, Thomas Longerich, Fabian Geisler, Mathias Heikenwalder, Achim Weber, Mihael Vucur, and Tom Luedde. https://www.pnas.org/content/118/12/e2007194118.abstract


Caspases and Granzyme B


Noncanonical Roles of Caspase-4 and Caspase-5 in Heme-Driven IL-1β Release and Cell Death – Beatriz E. Bolívar, Alexandra N. Brown-Suedel, Brittany A. Rohrman, Chloé I. Charendoff, Vanda Yazdani, John D. Belcher, Gregory M. Vercellotti, Jonathan M. Flanagan and Lisa Bouchier-Hayes. https://www.jimmunol.org/content/early/2021/03/18/jimmunol.2000226

Discovery of a caspase cleavage motif antibody reveals insights into noncanonical inflammasome function – Christopher W. Davies, Irma Stowe, Qui T. Phung, Hoangdung Ho, Corey E. Bakalarski, Aaron Gupta, Yingnan Zhang, Jennie R. Lill, Jian Payandeh, Nobuhiko Kayagaki, and James T. Koerber. https://www.pnas.org/content/118/12/e2018024118.abstract

Cytotoxic CD8+ T cells promote granzyme B-dependent adverse post-ischemic cardiac remodeling – Icia Santos-Zas, Jeremie Lemarié, Ivana Zlatanova, Marine Cachanado, Jean-Christophe Seghezzi, Hakim Benamer, Pascal Goube, Marie Vandestienne, Raphael Cohen, Maya Ezzo, Vincent Duval, Yujiao Zhang, Jin-Bo Su, Alain Bizé, Lucien Sambin, Philippe Bonnin, Maxime Branchereau, Christophe Heymes, Corinne Tanchot, José Vilar, Clement Delacroix, Jean-Sebastien Hulot, Clement Cochain, Patrick Bruneval, Nicolas Danchin, Alain Tedgui, Ziad Mallat, Tabassome Simon, Bijan Ghaleh, Jean-Sébastien Silvestre and Hafid Ait-Oufella. https://www.nature.com/articles/s41467-021-21737-9


Necroptosis


TNF-induced necroptosis initiates early autophagy events via RIPK3-dependent AMPK activation, but inhibits late autophagy – Wenxian Wu, Xiaojing Wang, Yadong Sun, Niklas Berleth, Jana Deitersen, David Schlütermann, Fabian Stuhldreier, Nora Wallot-Hieke, María José Mendiburo, Jan Cox, Christoph Peter, Ann Kathrin Bergmann and Björn Stork. https://www.tandfonline.com/doi/full/10.1080/15548627.2021.1899667

A specific RIP3+ subpopulation of microglia promotes retinopathy through a hypoxia-triggered necroptotic mechanism – Chang He, Yan Liu, Zijing Huang, Ziqi Yang, Tian Zhou, Sheng Liu, Zhaozhe Hao, Jing Wang, Qiumin Feng, Yizhi Liu, Yihai Cao, and Xialin Liu. https://www.pnas.org/content/118/11/e2023290118.abstract?etoc

The amyloid structure of mouse RIPK3 (receptor interacting protein kinase 3) in cell necroptosis – Xia-lian Wu, Hong Hu, Xing-qi Dong, Jing Zhang, Jian Wang, Charles D. Schwieters, Jing Liu, Guo-xiang Wu, Bing Li, Jing-yu Lin, Hua-yi Wang and Jun-xia Lu. https://www.nature.com/articles/s41467-021-21881-2


Pyroptosis / Gasdermin D


Proteomics reveals distinct mechanisms regulating the release of cytokines and alarmins during pyroptosis – Kshiti Phulphagar, Lars I. Kühn, Stefan Ebner, Annika Frauenstein, Jonathan J. Swietlik, Jan Rieckmann, Felix Meissner. https://www.cell.com/cell-reports/fulltext/S2211-1247(21)00140-6

Gasdermin D mediates the maturation and release of IL-1α downstream of inflammasomes – Kohsuke Tsuchiya, Shoko Hosojima, Hideki Hara, Hiroko Kushiyama, Mamunur Rashid Mahib, Takeshi Kinoshita, Takashi Suda. https://www.cell.com/cell-reports/fulltext/S2211-1247(21)00201-1

SARS-CoV-2 engages inflammasome and pyroptosis in human primary monocytes – André C. Ferreira, Vinicius Cardoso Soares, Isaclaudia G. de Azevedo-Quintanilha, Suelen da Silva Gomes Dias, Natalia Fintelman-Rodrigues, Carolina Q. Sacramento, Mayara Mattos, Caroline S. de Freitas, Jairo R. Temerozo, Lívia Teixeira, Eugenio Damaceno Hottz, Ester A. Barreto, Camila R. R. Pão, Lohanna Palhinha, Milene Miranda, Dumith Chequer Bou-Habib, Fernando A. Bozza, Patrícia T. Bozza and Thiago Moreno L. Souza. https://www.nature.com/articles/s41420-021-00428-w


Ferroptosis


A compendium of kinetic modulatory profiles identifies ferroptosis regulators – Megan Conlon, Carson D. Poltorack, Giovanni C. Forcina, David A. Armenta, Melodie Mallais, Marcos A. Perez, Alex Wells, Alexis Kahanu, Leslie Magtanong, Jennifer L. Watts, Derek A. Pratt and Scott J. Dixon. https://www.nature.com/articles/s41589-021-00751-4

The Lipogenic Regulator SREBP2 Induces Transferrin in Circulating Melanoma Cells and Suppresses Ferroptosis – Xin Hong, Whijae Roh, Ryan J. Sullivan, Keith H.K. Wong, Ben S. Wittner, Hongshan Guo, Taronish D. Dubash, Moshe Sade-Feldman, Benjamin Wesley, Elad Horwitz, Genevieve M. Boland, Dieuwke L. Marvin, Todd Bonesteel, Chenyue Lu, François Aguet, Risa Burr, Samuel S. Freeman, Laxmi Parida, Katherine Calhoun, Michelle K. Jewett, Linda T. Nieman, Nir Hacohen, Anders M. Näär, David T. Ting, Mehmet Toner, Shannon L. Stott, Gad Getz, Shyamala Maheswaran and Daniel A. Haber. https://cancerdiscovery.aacrjournals.org/content/11/3/678

Ferroptosis Inducers Are a Novel Therapeutic Approach for Advanced Prostate Cancer – Ali Ghoochani, En-Chi Hsu, Merve Aslan, Meghan A. Rice, Holly M. Nguyen, James D. Brooks, Eva Corey, Ramasamy Paulmurugan and Tanya Stoyanova. https://cancerres.aacrjournals.org/content/81/6/1583

Lipid peroxidation and the subsequent cell death transmitting from ferroptotic cells to neighboring cells – Hironari Nishizawa, Mitsuyo Matsumoto, Guan Chen, Yusho Ishii, Keisuke Tada, Masafumi Onodera, Hiroki Kato, Akihiko Muto, Kozo Tanaka and Kazuhiko Igarashi. https://www.nature.com/articles/s41419-021-03613-y


Efferocytosis, entosis etc


Pulsatile contractions promote apoptotic cell extrusion in epithelial tissues – Youmna Atieh, Thomas Wyatt, Ana Maria Zaske, George T. Eisenhoffer. https://www.cell.com/current-biology/fulltext/S0960-9822(20)31825-X

Mechanotransduction activates RhoA in the neighbors of apoptotic epithelial cells to engage apical extrusion – Kinga Duszyc, Guillermo A. Gomez, Anne K. Lagendijk, Mei-Kwan Yau, Bageshri Naimish Nanavati, Briony L. Gliddon, Thomas E. Hall, Suzie Verma, Benjamin M. Hogan, Stuart M. Pitson, David P. Fairlie, Robert G. Parton, Alpha S. Yap. https://www.cell.com/current-biology/fulltext/S0960-9822(21)00036-1

Caspase cleavage releases a nuclear protein fragment that stimulates phospholipid scrambling at the plasma membrane – Masahiro Maruoka, Panpan Zhang, Hiromi Mori, Eiichi Imanishi, Daniel M. Packwood, Hiroshi Harada, Hidetaka Kosako, Jun Suzuki. https://www.cell.com/molecular-cell/fulltext/S1097-2765(21)00135-0


Bcl-2 family proteins


Structure of detergent-activated BAK dimers derived from the inert monomer – Richard W. Birkinshaw, Sweta Iyer, Daisy Lio, Cindy S. Luo,J ason M. Brouwer, Michelle S. Miller, Adeline Y. Robin, Rachel T. Uren, Grant Dewson, Ruth M. Kluck, Peter M. Colman, Peter E. Czabotar. https://www.cell.com/molecular-cell/fulltext/S1097-2765(21)00182-9

Phase IB Study of Osimertinib in Combination with Navitoclax in EGFR-mutant NSCLC Following Resistance to Initial EGFR Therapy (ETCTN 9903) – Erin M. Bertino, Ryan D. Gentzler, Sarah Clifford, Jill Kolesar, Alona Muzikansky, Eric B. Haura, Zofia Piotrowska, D. Ross Camidge, Thomas E. Stinchcombe, Christine Hann, Jyoti Malhotra, Liza C. Villaruz, Cloud P. Paweletz, Christie L. Lau, Lynette Sholl, Naoko Takebe, Jeffrey A. Moscow, Geoffrey I. Shapiro, Pasi A. Jänne and Geoffrey R. Oxnard. https://clincancerres.aacrjournals.org/content/27/6/1604

Hypertonicity counteracts MCL‐1 and renders BCL‐XL a synthetic lethal target in head and neck cancer – Sina Heimer, Gertrud Knoll, Patrick Neubert, Karin P. Hammer, Stefan Wagner, Richard J. Bauer, Jonathan Jantsch, Martin Ehrenschwender. https://febs.onlinelibrary.wiley.com/doi/full/10.1111/febs.15492

Network-based systems pharmacology reveals heterogeneity in LCK and BCL2 signaling and therapeutic sensitivity of T-cell acute lymphoblastic leukemia – Yoshihiro Gocho, Jingjing Liu, Jianzhong Hu, Wentao Yang, Neekesh V. Dharia, Jingliao Zhang, Hao Shi, Guoqing Du, August John, Ting-Nien Lin, Jeremy Hunt, Xin Huang, Bensheng Ju, Lauren Rowland, Lei Shi, Dylan Maxwell, Brandon Smart, Kristine R. Crews, Wenjian Yang, Kohei Hagiwara, Yingchi Zhang, Kathryn Roberts, Hong Wang, Elias Jabbour, Wendy Stock, Bartholomew Eisfelder, Elisabeth Paietta, Scott Newman, Giovanni Roti, Mark Litzow, John Easton, Jinghui Zhang, Junmin Peng, Hongbo Chi, Stanley Pounds, Mary V. Relling, Hiroto Inaba, Xiaofan Zhu, Steven Kornblau, Ching-Hon Pui, Marina Konopleva, David Teachey, Charles G. Mullighan, Kimberly Stegmaier, William E. Evans, Jiyang Yu and Jun J. Yang. https://www.nature.com/articles/s43018-020-00167-4

Combined inhibition of XIAP and BCL2 drives maximal therapeutic efficacy in genetically diverse aggressive acute myeloid leukemia – Mari Hashimoto, Yoriko Saito, Ryo Nakagawa, Ikuko Ogahara, Shinsuke Takagi, Sadaaki Takata, Hanae Amitani, Mikiko Endo, Hitomi Yuki, Jordan A. Ramilowski, Jessica Severin, Ri-ichiroh Manabe, Takashi Watanabe, Kokoro Ozaki, Akiko Kaneko, Hiroshi Kajita, Saera Fujiki, Kaori Sato, Teruki Honma, Naoyuki Uchida, Takehiro Fukami, Yasushi Okazaki, Osamu Ohara, Leonard D. Shultz, Makoto Yamada, Shuichi Taniguchi, Paresh Vyas, Michiel de Hoon, Yukihide Momozawa and Fumihiko Ishikawa. https://www.nature.com/articles/s43018-021-00177-w

The deubiquitinase (DUB) USP13 promotes Mcl-1 stabilisation in cervical cancer – Ethan L. Morgan, Molly R. Patterson, Diego Barba-Moreno, James A. Scarth, Adam Wilson and Andrew Macdonald. https://www.nature.com/articles/s41388-021-01679-8

BOK controls apoptosis by Ca2+ transfer through ER-mitochondrial contact sites – Marcos A. Carpio, Robert E. Means, Allison L. Brill, Alva Sainz, Barbara E. Ehrlich, Samuel G. Katz. https://www.cell.com/cell-reports/fulltext/S2211-1247(21)00141-8

Cullin-5 neddylation-mediated NOXA degradation is enhanced by PRDX1 oligomers in colorectal cancer – Shoufang Xu, Yilei Ma, Qingchao Tong, Jun Yang, Jia Liu, Yanzhong Wang, Guoli Li, Jin Zeng, Sining Fang, Fengying Li, Xinyou Xie and Jun Zhang. https://www.nature.com/articles/s41419-021-03557-3


Miscellanous


Circulating BiP/Grp78 is a novel prognostic marker for sepsis‐mediated immune cell death – Marcel Doerflinger  Boris Reljic  Joseph Menassa  Christina Nedeva  Irvin Jose  Pierre Faou  Liana Mackiewicz  Ashley Mansell  Marc Pellegrini  Richard Hotchkiss  Hamsa Puthalakath. https://febs.onlinelibrary.wiley.com/doi/abs/10.1111/febs.15552

Conversion of the death inhibitor ARC to a killer activates pancreatic β cell death in diabetes – Wendy M. McKimpson, Yun Chen, James A. Irving, Min Zheng, Jeremy Weinberger, Wilson Lek Wen Tan, Zenia Tiang, Alistair M. Jagger, Streamson C. Chua Jr., Jeffrey E. Pessin, Roger S.-Y. Foo, David A. Lomas, Richard N. Kitsis. https://www.cell.com/developmental-cell/fulltext/S1534-5807(21)00122-2

Monitoring tumor cell death in murine tumor models using deuterium magnetic resonance spectroscopy and spectroscopic imaging – Friederike Hesse, Vencel Somai, Felix Kreis, Flaviu Bulat, Alan J. Wright, and Kevin M. Brindle. https://www.pnas.org/content/118/12/e2014631118.abstract

Conserved role of ENDOG in promoting autophagy – Jianshuang Li, Wenjun Wang and Qinghua Zhou. https://www.tandfonline.com/doi/abs/10.1080/15548627.2021.1907513

The BAX-binding protein MOAP1 associates with LC3 and promotes closure of the phagophore – Hao-Chun Chang, Ran N. Tao, Chong Teik Tan, Ya Jun Wu, Boon Huat Bay and Victor C. Yu. https://www.tandfonline.com/doi/full/10.1080/15548627.2021.1896157


Reviews


The intrinsic immunogenic properties of cancer cell lines, immunogenic cell death, and how these influence host antitumor immune responses – Tania Løve Aaes and Peter Vandenabeele. https://www.nature.com/articles/s41418-020-00658-y

The regulation of necroptosis by post-translational modifications – Yanxiang Meng, Jarrod J. Sandow, Peter E. Czabotar and James M. Murphy. https://www.nature.com/articles/s41418-020-00722-7

An unexpected turn of fortune: targeting TRAIL-Rs in KRAS-driven cancer – Von Karstedt S, Walczak H.. https://www.nature.com/articles/s41420-020-0249-4

Death sentence: The tale of a fallen endoplasmic reticulum – Eoghan P.McGrath, Federica G.Centonze, Eric Chevet, Tony Avril, Elodie Lafont. https://www.sciencedirect.com/science/article/abs/pii/S0167488921000550


Comments


Challenges in small-molecule target identification: a commentary on “BDA-366, a putative Bcl-2 BH4 domain antagonist, induces apoptosis independently of Bcl-2 in a variety of cancer cell models” – Richard W. Birkinshaw. https://www.nature.com/articles/s41418-020-00717-4

NINJ1, rupturing swollen membranes for cataclysmic cell lysis – Yupeng Wang, Feng Shao. https://www.cell.com/molecular-cell/fulltext/S1097-2765(21)00173-8

The long road to TRAIL therapy: a TRAILshort detour – Aswath P. Chandrasekar, Mark Maynes, and  Andrew D. Badley. https://impactjournals.us9.list-manage.com/track/click?u=133779c099e52b6fa9d4dec2e&id=26664d3f1d&e=923b339f12

Linking hyperosmotic stress and apoptotic sensitivity – Daniela Stöhr, Markus Rehm. https://febs.onlinelibrary.wiley.com/doi/full/10.1111/febs.15520

From friend to foe: Pro-apoptotic action of nuclear ARC in diabetes – Toshiharu Onodera, Philipp E. Scherer. https://www.cell.com/developmental-cell/fulltext/S1534-5807(21)00198-2

Epithelia arm up for dead-cell clearance – Paulina Strzyz. https://www.nature.com/articles/s41580-021-00351-z

Profile of Judy Lieberman – Jennifer Viegas. https://www.pnas.org/content/118/12/e2103317118?etoc=

ApoList – February 2021


Reviews


The Antisocial Network: Cross Talk Between Cell Death Programs in Host Defense – Annelise G. Snyder and Andrew Oberst. https://www.annualreviews.org/doi/10.1146/annurev-immunol-112019-072301

Cell death pathways: intricate connections and disease implications – Matthias Kist, Domagoj Vucic. https://www.embopress.org/doi/abs/10.15252/embj.2020106700

Location, location, location: A compartmentalized view of TNF-induced necroptotic signaling – André L. Samson, Sarah E. Garnish, Joanne M. Hildebrand, and James M. Murphy. https://stke.sciencemag.org/content/14/668/eabc6178

Modes of Regulated Cell Death in Cancer – Elle Koren and Yaron Fuchs. https://cancerdiscovery.aacrjournals.org/content/11/2/245

Fueling the Fire: Inflammatory Forms of Cell Death and Implications for Cancer Immunotherapy – Sheera R. Rosenbaum, Nicole A. Wilski and Andrew E. Aplin. https://cancerdiscovery.aacrjournals.org/content/11/2/266

Ferroptosis: mechanisms, biology and role in disease – Xuejun Jiang, Brent R. Stockwell and Marcus Conrad. https://www.nature.com/articles/s41580-020-00324-8

Role of apoptosis repressor with caspase recruitment domain (ARC) in cell death and cardiovascular disease – Jing Zhang, Xianxin Zheng, Peiyan Wang, Jianxun Wang, Wei Ding. https://link.springer.com/article/10.1007/s10495-020-01653-x

The application of BH3 mimetics in myeloid leukemias – Narissa Parry, Helen Wheadon and Mhairi Copland. https://www.nature.com/articles/s41419-021-03500-6

Discovery of linear ubiquitination, a crucial regulator for immune signaling and cell death – Kazuhiro Iwai. https://febs.onlinelibrary.wiley.com/doi/full/10.1111/febs.15471

The Role of Mitochondria in Pyroptosis – Qian Li, Nengxian Shi, Chen Cai, Mingming Zhang, Jing He, Ying Tan and Weijun Fu. https://www.frontiersin.org/articles/10.3389/fcell.2020.630771/full

Ubiquitination in the regulation of inflammatory cell death and cancer – Peter E. Cockram, Matthias Kist, Sumit Prakash, Si-Han Chen, Ingrid E. Wertz and Domagoj Vucic. https://www.nature.com/articles/s41418-020-00708-5


Bcl-2 family proteins


Proteolysis-targeting chimera against BCL-XL destroys tumor-infiltrating regulatory T cells – Ryan Kolb, Umasankar De, Sajid Khan, Yuewan Luo, Myung-Chul Kim, Haijun Yu, Chaoyan Wu, Jiao Mo, Xin Zhang, Peiyi Zhang, Xuan Zhang, Nicholas Borcherding, Daniel Koppel, Yang-Xin Fu, Song Guo Zheng, Dorina Avram, Guangrong Zheng, Daohong Zhou and Weizhou Zhang. https://www.nature.com/articles/s41467-021-21573-x

Eltrombopag directly inhibits BAX and prevents cell death – Adam Z. Spitz, Emmanouil Zacharioudakis, Denis E. Reyna, Thomas P. Garner and Evripidis Gavathiotis. https://www.nature.com/articles/s41467-021-21224-1

Characteristics of intracellular propagation of mitochondrial BAX recruitment during apoptosis – Joshua A. Grosser, Margaret E. Maes, Robert W. Nickells. https://link.springer.com/article/10.1007/s10495-020-01654-w

Fluorizoline-induced apoptosis requires prohibitins in nematodes and human cells – José Saura-Esteller, Ismael Sánchez-Vera, Sonia Núñez-Vázquez, Judith Jabalquinto-Carrasco, Ana M. Cosialls, Lorena Mendive-Tapia, Dmytro Kukhtar, Manuel D. Martínez-Bueno, Rodolfo Lavilla, Julián Cerón, Marta Artal-Sanz, Gabriel Pons, Daniel Iglesias-Serret, Joan Gil. https://link.springer.com/article/10.1007/s10495-020-01651-z

NOXA upregulation by the prohibitin‐binding compound fluorizoline is transcriptionally regulated by integrated stress response‐induced ATF3 and ATF4 – Sonia Núñez‐Vázquez, Ismael Sánchez‐Vera, José Saura‐Esteller, Ana M. Cosialls, Anaïs F.M. Noisier, Fernando Albericio, Rodolfo Lavilla, Gabriel Pons, Daniel Iglesias‐Serret, Joan Gil. https://febs.onlinelibrary.wiley.com/doi/abs/10.1111/febs.15480

TOM20-mediated transfer of Bcl2 from ER to MAM and mitochondria upon induction of apoptosis – Lisenn Lalier, Vincent Mignard, Marie-Pierre Joalland, Didier Lanoé, Pierre-François Cartron, Stéphen Manon and François M. Vallette. https://www.nature.com/articles/s41419-021-03471-8


Death receptors


Cryo-EM structural analysis of FADD:Caspase-8 complexes defines the catalytic dimer architecture for co-ordinated control of cell fate – Joanna L. Fox, Michelle A. Hughes, Xin Meng, Nikola A. Sarnowska, Ian R. Powley, Rebekah Jukes-Jones, David Dinsdale, Timothy J. Ragan, Louise Fairall, John W. R. Schwabe, Nobuhiro Morone, Kelvin Cain and Marion MacFarlane. https://www.nature.com/articles/s41467-020-20806-9

Ancestral role of TNF-R pathway in cell differentiation in the basal metazoan Hydra – Mona Steichele, Lara S. Sauermann, Ann-Christine König, Stefanie Hauck and Angelika Böttger. http://jcs.biologists.org/content/134/2/jcs255422?etoc

A distinct CD38+CD45RA+ population of CD4+, CD8+, and double-negative T cells is controlled by FA – Maria Elena Maccari; Sebastian Fuchs; Patrick Kury ; Geoffroy Andrieux; Simon Völkl; Bertram Bengsch; Myriam Ricarda Lorenz; Maximilian Heeg ; Jan Rohr; Sabine Jägle; Carla N. Castro; Miriam Groß; Ursula Warthorst ; Christoph König; Ilka Fuchs; Carsten Speckmann; Julian Thalhammer; Friedrich G. Kapp ; Markus G. Seidel; Gregor Dückers; Stefan Schönberger; Catharina Schütz; Marita Führer; Robin Kobbe; Dirk Holzinger; Christian Klemann; Petr Smisek; Stephen Owens; Gerd Horneff; Reinhard Kolb; Nora Naumann-Bartsch; Maurizio Miano; Julian Staniek; Marta Rizzi; Tomas Kalina; Pascal Schneider; Anika Erxleben; Rolf Backofen ; Arif Ekici; Charlotte M. Niemeyer; Klaus Warnatz; Bodo Grimbacher; Hermann Eibel ; Andreas Mackensen; Andreas Philipp Frei; Klaus Schwarz; Melanie Boerries; Stephan Ehl; Anne Rensing-Ehl. https://rupress.org/jem/article-abstract/218/2/e20192191/211525

A TRAIL from gut to brain – John F. Foley. https://stke.sciencemag.org/content/14/671/eabh1677


Caspases and IAPs


Engineering caspase 7 as an affinity reagent to capture proteolytic products – Amir S. Razai, Scott J. Snipas, Marcin Poreba, Domenico Fasci, Guy S. Salvesen. https://febs.onlinelibrary.wiley.com/doi/abs/10.1111/febs.15467

Smac-mimetics reduce numbers and viability of human osteoclasts – Ingrid Nyhus Moen, Marita Westhrin, Erling Håland, Markus Haug, Unni Nonstad, Merisa Klaharn, Therese Standal and Kristian K. Starheim. https://www.nature.com/articles/s41420-021-00415-1

Targeting the ESCRT-III component CHMP2A for noncanonical Caspase-8 activation on autophagosomal membranes – Tatsuya Hattori, Yoshinori Takahashi, Longgui Chen, Zhenyuan Tang, Carson A. Wills, Xinwen Liang and Hong-Gang Wang. https://www.nature.com/articles/s41418-020-00610-0


Necroptosis


USP22 controls necroptosis by regulating receptor‐interacting protein kinase 3 ubiquitination – Jens Roedig, Lisa Kowald, Thomas Juretschke, Rebekka Karlowitz, Behnaz Ahangarian Abhari, Heiko Roedig, Simone Fulda, Petra Beli, Sjoerd JL van Wijk. https://www.embopress.org/doi/full/10.15252/embr.202050163

Somatic Epigenetic Silencing of RIPK3 Inactivates Necroptosis and Contributes to Chemoresistance in Malignant Mesothelioma – Yinfei Tan, Eleonora Sementino, Mitchell Cheung, Suraj Peri, Craig W. Menges, Anna-Mariya Kukuyan, Ting Zhang, Vladimir Khazak, Lauren A. Fox, Eric A. Ross, Suresh Ramanathan, Suresh C. Jhanwar, Raja M. Flores, Siddharth Balachandran and Joseph R. Testa. https://clincancerres.aacrjournals.org/content/27/4/1200

A class of viral inducer of degradation of the necroptosis adaptor RIPK3 regulates virus-induced inflammation – Zhijun Liu, Himani Nailwal, Jonah Rector, Masmudur M. Rahman, Richard Sam, Grant McFadden, Francis Ka-Ming Chan. https://www.cell.com/immunity/fulltext/S1074-7613(20)30507-0


Pyroptosis


Apaf-1 Pyroptosome Senses Mitochondrial Permeability Transition – Wanfeng Xu, Yuan Che, Quan Zhang, Hai Huang, Chujie Ding, Yun Wang, Guangji Wang, Lijuan Cao, Haiping Hao. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(20)30653-7

Caspase 3/GSDME-dependent pyroptosis contributes to chemotherapy drug-induced nephrotoxicity – Xiujin Shen, Haibing Wang, Chunhua Weng, Hong Jiang and Jianghua Chen. https://www.nature.com/articles/s41419-021-03458-5

Gasdermin E deficiency attenuates acute kidney injury by inhibiting pyroptosis and inflammation – Weiwei Xia, Yuanyuan Li, Mengying Wu, Qianqian Jin, Qian Wang, Shuzhen Li, Songming Huang, Aihua Zhang, Yue Zhang and Zhanjun Jia. https://www.nature.com/articles/s41419-021-03431-2


Ferroptosis


Phospholipase iPLA2β averts ferroptosis by eliminating a redox lipid death signal – Wan-Yang Sun, Vladimir A. Tyurin, Karolina Mikulska-Ruminska, Indira H. Shrivastava, Tamil S. Anthonymuthu, Yu-Jia Zhai, Ming-Hai Pan, Hai-Biao Gong, Dan-Hua Lu, Jie Sun, Wen-Jun Duan, Sergey Korolev, Andrey Y. Abramov, Plamena R. Angelova, Ian Miller, Ofer Beharier, Gao-Wei Mao, Haider H. Dar, Alexandr A. Kapralov, Andrew A. Amoscato, Teresa G. Hastings, Timothy J. Greenamyre, Charleen T. Chu, Yoel Sadovsky, Ivet Bahar, Hülya Bayır, Yulia Y. Tyurina, Rong-Rong He and Valerian E. Kagan. https://www.nature.com/articles/s41589-020-00734-x

Polyunsaturated fatty acid biosynthesis pathway determines ferroptosis sensitivity in gastric cancer – Ji-Yoon Lee, Miso Nam, Hye Young Son, Kwangbeom Hyun, Seo Young Jang, Jong Woo Kim, Min Wook Kim, Youngae Jung , Eunji Jang, Seon-Jin Yoon 8, Jungeun Kim, Jihye Kim, Jinho Seo, Jeong-Ki Min, Kyoung-Jin Oh, Baek-Soo Han, Won Kon Kim, Kwang-Hee Bae, Jaewhan Song, Jaehoon Kim, Yong-Min Huh, Geum-Sook Hwang, Eun-Woo Lee, Sang Chul Lee. https://www.pnas.org/content/117/51/32433.long


Entosis, extrusion, efferocytosis


p53-dependent elimination of aneuploid mitotic offspring by entosis – Jianqing Liang, Zubiao Niu, Bo Zhang, Xiaochen Yu, You Zheng, Chenxi Wang, He Ren, Manna Wang, Banzhan Ruan, Hongquan Qin, Xin Zhang, Songzhi Gu, Xiaoyong Sai, Yanhong Tai, Lihua Gao, Li Ma, Zhaolie Chen, Hongyan Huang, Xiaoning Wang and Qiang Sun. https://www.nature.com/articles/s41418-020-00645-3

Mechanical competition triggered by innate immune signaling drives the collective extrusion of bacterially infected epithelial cells – Effie E. Bastounis, Francisco Serrano-Alcalde, Prathima Radhakrishnan, Patrik Engström, María J. Gómez-Benito, Mackenzi S. Oswald, Yi-Ting Yeh, Jason G. Smith, Matthew D. Welch, José M. García-Aznar, Julie A. Theriot. https://www.cell.com/developmental-cell/fulltext/S1534-5807(21)00070-8

Calcium ions trigger the exposure of phosphatidylserine on the surface of necrotic cells – Yoshitaka Furuta, Omar Pena-Ramos, Zao Li, Lucia Chiao, Zheng Zhou. https://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1009066


Miscellanous


Centriolar distal appendages activate the centrosome‐PIDDosome‐p53 signalling axis via ANKRD26 – Matteo Burigotto, Alessia Mattivi, Daniele Migliorati, Giovanni Magnani, Chiara Valentini, Michela Roccuzzo, Martin Offterdinger, Massimo Pizzato, Alexander Schmidt, Andreas Villunger, Stefano Maffini, Luca L Fava. https://www.embopress.org/doi/full/10.15252/embj.2020104844

ANKRD26 recruits PIDD1 to centriolar distal appendages to activate the PIDDosome following centrosome amplification – Lauren T Evans, Taylor Anglen, Phillip Scott, Kimberly Lukasik, Jadranka Loncarek, Andrew J Holland. https://www.embopress.org/doi/abs/10.15252/embj.2020105106

Intracellular leucine-rich alpha-2-glycoprotein-1 competes with Apaf-1 for binding cytochrome c in protecting MCF-7 breast cancer cells from apoptosis – Ronald Jemmerson, Katherine Staskus, LeeAnn Higgins, Kathleen Conklin, Ameeta Kelekar. https://link.springer.com/article/10.1007/s10495-020-01647-9

Altered structure and dynamics of pathogenic cytochrome c variants correlate with increased apoptotic activity – Matthias Fellner; Rinky Parakra; Kirstin O. McDonald; Itamar Kass ; Guy N.L. Jameson; Sigurd M. Wilbanks; Elizabeth C. Ledgerwood. https://portlandpress.com/biochemj/article-abstract/478/3/669/227642/

ApoList – January 2021

 


Pyroptosis and other forms of cell death


NINJ1 mediates plasma membrane rupture during lytic cell death – Nobuhiko Kayagaki, Opher S. Kornfeld, Bettina L. Lee, Irma B. Stowe, Karen O’Rourke, Qingling Li, Wendy Sandoval, Donghong Yan, Jing Kang, Min Xu, Juan Zhang, Wyne P. Lee, Brent S. McKenzie, Gözde Ulas, Jian Payandeh, Merone Roose-Girma, Zora Modrusan, Rohit Reja, Meredith Sagolla, Joshua D. Webster, Vicky Cho, T. Daniel Andrews, Lucy X. Morris, Lisa A. Miosge, Christopher C. Goodnow, Edward M. Bertram and Vishva M. Dixit – https://www.nature.com/articles/s41586-021-03218-7

Role and dynamics of vacuolar pH during cell-in-cell mediated death – Yan Su, He Ren, Meng Tang, You Zheng, Bo Zhang, Chenxi Wang, Xinyu Hou, Zubiao Niu, Zhongyi Wang, Xiaoyan Gao, Lihua Gao, Hong Jiang, Zhaolie Chen, Tianzhi Luo and Qiang Sun. https://www.nature.com/articles/s41419-021-03396-2

Coral gasdermin triggers pyroptosis – Shuai Jiang, Zhi Zhou, Yuanyuan Sun, Tengfei Zhang, Li Su. https://immunology.sciencemag.org/content/5/54/eabd2591


Death receptors


Gut-licensed IFNγ+ NK cells drive LAMP1+TRAIL+ anti-inflammatory astrocytes – Liliana M. Sanmarco, Michael A. Wheeler, Cristina Gutiérrez-Vázquez, Carolina Manganeli Polonio, Mathias Linnerbauer, Felipe A. Pinho-Ribeiro, Zhaorong Li, Federico Giovannoni, Katelyn V. Batterman, Giulia Scalisi, Stephanie E. J. Zandee, Evelyn S. Heck, Moneera Alsuwailm, Douglas L. Rosene, Burkhard Becher, Isaac M. Chiu, Alexandre Prat and Francisco J. Quintana. https://www.nature.com/articles/s41586-020-03116-4

Autophagy protects tumors from T cell–mediated cytotoxicity via inhibition of TNFα-induced apoptosis – Tara M. Young, Claudia Reyes, Elizabeth Pasnikowski, Carla Castanaro, Chung Wong, Corinne E. Decker, Joyce Chiu, Hang Song, Yi Wei, Yu Bai, Brian Zambrowicz, Gavin Thurston, Christopher Daly. https://immunology.sciencemag.org/content/5/54/eabb9561

Synergism of TNF-α and IFN-γ Triggers Inflammatory Cell Death, Tissue Damage, and Mortality in SARS-CoV-2 Infection and Cytokine Shock Syndromes – Rajendra Karki, Bhesh Raj Sharma, Shraddha Tuladhar, Evan Peter Williams, Lillian Zalduondo, Parimal Samir, Min Zheng, Balamurugan Sundaram, Balaji Banoth, R.K. Subbarao Malireddi, Patrick Schreiner, Geoffrey Neale, Peter Vogel, Richard Webby, Colleen Beth Jonsson, Thirumala-Devi Kanneganti. https://www.cell.com/cell/fulltext/S0092-8674(20)31542-7


Necroptosis


RIP3-mediated necroptosis is regulated by inter-filament assembly of RIP homotypic interaction motif – Hong Hu, Xialian Wu, Guoxiang Wu, Ning Nan, Jing Zhang, Xinxin Zhu, Yu Zhang, Zhaoqian Shu, Jia Liu, Xiaoyan Liu, Junxia Lu and Huayi Wang. https://www.nature.com/articles/s41418-020-0598-9

O-GlcNAcylation ameliorates the pathological manifestations of Alzheimer’s disease by inhibiting necroptosis – Jinsu Park , Hee-Jin Ha, Eun Seon Chung, Seung Hyun Baek, Yoonsuk Cho, Hark Kyun Kim, Jihoon Han, Jae Hoon Sul, Jeongmi Lee, Eunae Kim, Junsik Kim, Yong Ryoul Yang, Mikyoung Park, Sung Hyun Kim, Thiruma V. Arumugam, Hyemin Jang, Sang Won Seo, Pann-Ghill Suh, Dong-Gyu Jo. https://advances.sciencemag.org/content/7/3/eabd3207?utm

The necroptotic cell death pathway operates in megakaryocytes, but not in platelet synthesis – Diane Moujalled, Pradnya Gangatirkar, Maria Kauppi, Jason Corbin, Marion Lebois, James M. Murphy, Najoua Lalaoui, Joanne M. Hildebrand, John Silke, Warren S. Alexander and Emma C. Josefsson. https://www.nature.com/articles/s41419-021-03418-z

ZBP1 promotes LPS-induced cell death and IL-1β release via RHIM-mediated interactions with RIPK1 – Hayley I. Muendlein, Wilson M. Connolly, Zoie Magri, Irina Smirnova, Vladimir Ilyukha, Avishekh Gautam, Alexei Degterev and Alexander Poltorak. https://www.nature.com/articles/s41467-020-20357-z


Bcl-2 family proteins


Venetoclax Increases Intratumoral Effector T Cells and Antitumor Efficacy in Combination with Immune Checkpoint Blockade – Frederick J. Kohlhapp, Dipica Haribhai, Rebecca Mathew, Ryan Duggan, Paul A. Ellis, Rui Wang, Elisabeth A. Lasater, Yan Shi, Nimita Dave, Jacob J. Riehm, Valerie A. Robinson, An D. Do, Yijin Li, Christine J. Orr, Deepak Sampath, Aparna Raval, Mark Merchant, Anahita Bhathena, Ahmed Hamed Salem, Keith M. Hamel, Joel D. Leverson, Cherrie Donawho, William N. Pappano and Tamar Uziel. https://cancerdiscovery.aacrjournals.org/content/11/1/68

Impaired ribosome biogenesis checkpoint activation induces p53-dependent MCL-1 degradation and MYC-driven lymphoma death – Ana Domostegui, Suresh Peddigari, Carol A Mercer, Flavia Iannizzotto, Marta-Leonor Rodriguez, Marta Garcia-Cajide, Virginia Amador, Ramón Salazar, Sara C Kozma, Eric P Kusnadi, Jian Kang, Antonio Gentilella, Richard B Pearson, George Thomas, Joffrey Pelletier. https://ashpublications.org/blood/article/doi/10.1182/blood.2020007452/474958

GNA13 regulates BCL2 expression and the sensitivity of GCB-DLBCL cells to BCL2 inhibitors in a palmitoylation-dependent manner – Zhizhou Xia, Xiuli Zhang, Ping Liu, Ruihong Zhang, Zhangsen Huang, Donghe Li, Xinhua Xiao, Min Wu, Nannan Ning, Qianqian Zhang, Jianmin Zhang, Mingzhu Liu, Bo Jiao and Ruibao Ren. https://www.nature.com/articles/s41419-020-03311-1


Caspases


Phosphorylation by Aurora B kinase regulates caspase-2 activity and function – Yoon Lim, Dylan De Bellis, Jarrod J. Sandow, Luisa Capalbo, Pier Paolo D’Avino, James M. Murphy, Andrew I. Webb, Loretta Dorstyn and Sharad Kumar. https://www.nature.com/articles/s41418-020-00604-y


Ferroptosis


Membrane Damage during Ferroptosis Is Caused by Oxidation of Phospholipids Catalyzed by the Oxidoreductases POR and CYB5R1 – Bo Yan, Youwei Ai, Qi Sun, Yan Ma, Yang Cao, Jiawen Wang, Zhiyuan Zhang, Xiaodong Wang. https://www.cell.com/molecular-cell/fulltext/S1097-2765(20)30802-9

Tumor heterogeneity in autophagy-dependent ferroptosis – Jingbo Li, Jiao Liu, Yinghua Xu, Runliu Wu, Xin Chen, Xinxin Song, Herbert Zeh, Rui Kang, Daniel J. Klionsky, Xiaoyan Wang and Daolin Tang. https://www.tandfonline.com/doi/abs/10.1080/15548627.2021.1872241

NUPR1 is a critical repressor of ferroptosis – Jiao Liu, Xinxin Song, Feimei Kuang, Qiuhong Zhang, Yangchun Xie, Rui Kang, Guido Kroemer and Daolin Tang. https://www.nature.com/articles/s41467-021-20904-2


Miscellanous


A stress‐induced tyrosine‐tRNA depletion response mediates codon‐based translational repression and growth suppression – Doowon Huh, Maria C Passarelli, Jenny Gao, Shahnoza N Dusmatova, Clara Goin, Lisa Fish, Alexandra M Pinzaru, Henrik Molina, Zhiji Ren, Elizabeth A McMillan, Hosseinali Asgharian, Hani Goodarzi, Sohail F Tavazoie. https://www.embopress.org/doi/abs/10.15252/embj.2020106696


Reviews


Neuronal cell life, death, and axonal degeneration as regulated by the BCL-2 family proteins – James M. Pemberton, Justin P. Pogmore and David W. Andrews. https://www.nature.com/articles/s41418-020-00654-2

A venetoclax bench-to-bedside story – Courtney D. DiNardo and Marina Y. Konopleva. https://www.nature.com/articles/s43018-020-00165-6


Comments


Lighting a fire on the reef – Zhibin Zhang, Judy Lieberman. https://immunology.sciencemag.org/content/5/54/eabf0905

From the T-cell receptor to cancer therapy: an interview with Tak W. Mak – Tak W. Mak. https://www.nature.com/articles/s41418-020-00666-y

ApoList – December 2020

Bcl-2 family proteins


Inhibition of the anti-apoptotic protein MCL-1 severely suppresses human hematopoiesis – Sheila Bohler, Sehar Afreen, Juncal Fernandez-Orth, Eva-Maria Demmerath, Christian Molnar, Ying Wu, Julia Miriam Weiss, Venugopal Rao Mittapalli, Lukas Konstantinidis, Hagen Schmal, Mirjam Kunze, Miriam Erlacher. https://haematologica.org/article/view/haematol.2020.252130
 
BCL‐XL exerts a protective role against anemia caused by radiation‐induced kidney damage – Kerstin Brinkmann, Paul Waring, Stefan P Glaser, Verena Wimmer, Denny L Cottle, Ming Shen Tham, Duong Nhu, Lachlan Whitehead, Alex RD Delbridge, Guillaume Lessene, Ian M Smyth, Marco J Herold, Gemma L Kelly, Stephanie Grabow, Andreas Strasser. https://www.embopress.org/doi/abs/10.15252/embj.2020105561
 
BCL(X)L and BCL2 increase the metabolic fitness of breast cancer cells: a single-cell imaging study – Lucantoni F, Salvucci M, Düssmann H, Lindner AU, Lambrechts D, Prehn JHM. https://www.nature.com/articles/s41418-020-00683-x

The Heme-regulated Inhibitor Pathway Modulates Susceptibility of Poor Prognosis B-Lineage Acute Leukemia to BH3-Mimetics – Kaitlyn Hill Smith, Amit Budhraja, John Lynch, Kathryn Roberts, John C Panetta, Jon Patrick Connelly, Meghan E Turnis, Shondra M Pruett-Miller, John D Schuetz, Charles G. Mullighan and Joseph T Opferman. https://mcr.aacrjournals.org/content/early/2020/12/05/1541-7786.MCR-20-0586.abstract
 
MCL-1 is essential for survival but dispensable for metabolic fitness of FOXP3+ regulatory T cells – Charis E. Teh, Alissa K. Robbins, Darren C. Henstridge, Grant Dewson, Sarah T. Diepstraten, Gemma Kelly, Mark A. Febbraio, Sarah S. Gabriel, Lorraine A. O’Reilly, Andreas Strasser and Daniel H. D. Gray. https://www.nature.com/articles/s41418-020-0585-1
 
AZD4320, A Dual Inhibitor of Bcl-2 and Bcl-xL, Induces Tumor Regression in Hematologic Cancer Models without Dose-limiting Thrombocytopenia – Srividya B. Balachander, Steven W. Criscione, Kate F. Byth, Justin Cidado, Ammar Adam, Paula Lewis, Terry Macintyre, Shenghua Wen, Deborah Lawson, Kathleen Burke, Tristan Lubinski, Jeffrey W. Tyner, Stephen E. Kurtz, Shannon K. McWeeney, Jeffrey Varnes, R. Bruce Diebold, Thomas Gero, Stephanos Ioannidis, Edward J. Hennessy, William McCoull, Jamal C. Saeh, Areya Tabatabai, Omid Tavana, Nancy Su, Alwin Schuller, Mathew J. Garnett, Patricia Jaaks, Elizabeth A. Coker, Gareth P. Gregory, Andrea Newbold, Ricky W. Johnstone, Eric Gangl, Martin Wild, Michael Zinda, J. Paul Secrist, Barry R. Davies, Stephen E. Fawell and Francis D. Gibbons. https://clincancerres.aacrjournals.org/content/26/24/6535
 

Death receptors


A Fas-4-1BB fusion protein converts a death to a pro-survival signal and enhances T cell therapy – Shannon K. Oda; Kristin G. Anderson; Pranali Ravikumar; Patrick Bonson; Nicolas M. Garcia ; Cody M. Jenkins; Summer Zhuang; Andrew W. Daman; Edison Y. Chiu; Breanna M. Bates ; Philip D. Greenberg. https://rupress.org/jem/article/217/12/e20191166/152059/A-Fas-4-1BB-fusion-protein-converts-a-death-to-a
 
Site‐specific ubiquitination of the E3 ligase HOIP regulates apoptosis and immune signaling – Lilian M Fennell, Carlos Gomez Diaz, Luiza Deszcz, Anoop Kavirayani, David Hoffmann, Kota Yanagitani, Alexander Schleiffer, Karl Mechtler, Astrid Hagelkruys, Josef Penninger, Fumiyo Ikeda. https://www.embopress.org/doi/abs/10.15252/embj.2019103303
 
Ubiquitination of RIPK1 regulates its activation mediated by TNFR1 and TLRs signaling in distinct manners – Xingyan Li, Mengmeng Zhang, Xinyue Huang, Wei Liang, Ganquan Li, Xiaojuan Lu, Yanxia Li, Heling Pan, Linyu Shi, Hong Zhu, Lihui Qian, Bing Shan and Junying Yuan. https://www.nature.com/articles/s41467-020-19935-y
 

Necroptosis


Locking mixed-lineage kinase domain-like protein in its auto-inhibited state prevents necroptosis – Martin Rübbelke, Dennis Fiegen, Margit Bauer, Florian Binder, James Hamilton, Jim King, Sven Thamm, Herbert Nar and Markus Zeeb. https://www.pnas.org/content/117/52/33272.abstract?etoc
 
Discovery of a Potent RIPK3 Inhibitor for the Amelioration of Necroptosis-Associated Inflammatory Injury – Kaijiang Xia , Fang Zhu, Chengkui Yang , Shuwei Wu, Yu Lin, Haikuo Ma, Xiaoliang Yu , Cong Zhao , Yuting Ji , Wenxiang Ge, Jingrui Wang , Yayun Du , Wei Zhang , Tao Yang , Xiaohu Zhang and Sudan He. https://www.frontiersin.org/articles/10.3389/fcell.2020.606119/full
 

Ferroptosis (or lipid synthesis)


Ferroptotic damage promotes pancreatic tumorigenesis through a TMEM173/STING-dependent DNA sensor pathway – Enyong Dai, Leng Han, Jiao Liu, Yangchun Xie, Herbert J. Zeh, Rui Kang, Lulu Bai and Daolin Tang. https://www.nature.com/articles/s41467-020-20154-8
 
Oncogenic activation of PI3K-AKT-mTOR signaling suppresses ferroptosis via SREBP-mediated lipogenesis – Junmei Yi, Jiajun Zhu, Jiao Wu, Craig B. Thompson, and Xuejun Jiang. https://www.pnas.org/content/117/49/31189.abstract?etoc
 
HCAR1/MCT1 Regulates Tumor Ferroptosis through the Lactate-Mediated AMPK-SCD1 Activity and Its Therapeutic Implications – Youbo Zhao, Menghuan Li, Xuemei Yao, Yang Fei, Zhenghong Lin, Zhengguo Li, Kaiyong Cai, Yanli Zhao, Zhong Luo. https://www.cell.com/cell-reports/fulltext/S2211-1247(20)31476-5 
 
3D Culture Models with CRISPR Screens Reveal Hyperactive NRF2 as a Prerequisite for Spheroid Formation via Regulation of Proliferation and Ferroptosis – Nobuaki Takahashi, Patricia Cho, Laura M. Selfors, Hendrik J. Kuiken, Roma Kaul, Takuro Fujiwara, Isaac S. Harris, Tian Zhang, Steven P. Gygi, Joan S. Brugge. https://www.cell.com/molecular-cell/fulltext/S1097-2765(20)30693-6
 

Miscellanous


The E3 ligase UBR2 regulates cell death under caspase deficiency via Erk/MAPK pathway – Elodie Villa, Rachel Paul, Ophélie Meynet, Sophie Volturo, Guillaume Pinna and Jean-Ehrland Ricci. https://www.nature.com/articles/s41419-020-03258-3
 
Apoptosis in the fetal testis eliminates developmentally defective germ cell clones – Daniel H. Nguyen, Bikem Soygur, Su-Ping Peng, Safia Malki, Guang Hu and Diana J. Laird. https://www.nature.com/articles/s41556-020-00603-8
 
Intracellular cathepsin C levels determine sensitivity of cells to leucyl‐leucine methyl ester‐triggered apoptosis – Nežka Kavčič, Miha Butinar, Barbara Sobotič, Maruša Hafner Česen, Ana Petelin, Lea Bojić, Tina Zavašnik Bergant, Andreja Bratovš, Thomas Reinheckel, Boris Turk. https://febs.onlinelibrary.wiley.com/doi/abs/10.1111/febs.15326
 
Plasma exosomal miR-375-3p regulates mitochondria-dependent keratinocyte apoptosis by targeting XIAP in severe drug-induced skin reactions – Chen Zhang , ZhenLai Zhu, JiXin Gao, LuTing Yang, ErLe Dang, Hui Fang, Shuai Shao, ShaoLong Zhang, ChunYing Xiao, Xu Yuan, Wei Li, Riichiro Abe, HongJiang Qiao, Gang Wang, Meng Fu. https://stm.sciencemag.org/content/12/574/eaaw6142
 

Reviews


Caspase-2 Substrates: To Apoptosis, Cell Cycle Control, and Beyond – Alexandra N. Brown-Suedel and Lisa Bouchier-Hayes. https://www.frontiersin.org/articles/10.3389/fcell.2020.610022/full
 
Pore formation in regulated cell death – Hector Flores‐Romero, Uris Ros, Ana J Garcia‐Saez. https://www.embopress.org/doi/full/10.15252/embj.2020105753
 
The Metabolic Underpinnings of Ferroptosis – Jiashuo Zheng, Marcus Conrad. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(20)30544-1
 

Comments


Mitochondria in Their Prime Drive Venetoclax Response in Acute Myeloid Leukemia – Mette C. Kriegbaum, Krister Wennerberg. https://www.cell.com/cancer-cell/fulltext/S1535-6108(20)30549-3?

Targeting MCL1 to induce mitophagy is a potential therapeutic strategy for Alzheimer disease – 
Xufeng Cen , Xiaoyan Xu and Hongguang Xia. https://www.tandfonline.com/doi/full/10.1080/15548627.2020.1860542

ApoList – November 2020


Bcl-2 family proteins


Reduced Mitochondrial Apoptotic Priming Drives Resistance to BH3 Mimetics in Acute Myeloid Leukemia – Shruti Bhatt, Marissa S. Pioso, Elyse Anne Olesinski, Binyam Yilma Jeremy A. Ryan, Thelma Mashaka, Buon Leutz, Sophia Adamia, Haoling Zhu, Yanan Kuang, Abhishek Mogili, Abner J. Louissaint, Stephan R. Bohl, Annette S. Kim, Anita K. Mehta, Sneha Sanghavi, Youzhen Wang, Erick Morris, Ensar Halilovic, Cloud P. Paweletz, David M. Weinstock, Jacqueline S. Garcia, Anthony Letai. https://www.sciencedirect.com/science/article/pii/S1535610820305419

Mcl-1 and Bok transmembrane domains: Unexpected players in the modulation of apoptosis – Estefanía Lucendo,  Mónica Sancho,  Fabio Lolicato,  Matti Javanainen,  Waldemar Kulig, Diego Leiva, Gerard Duart, Vicente Andreu-Fernández,  Ismael Mingarro and Mar Orzáez. https://www.pnas.org/content/early/2020/10/21/2008885117.abstract

Viral Bcl2s’ transmembrane domain interact with host Bcl2 proteins to control cellular apoptosis – Maria Jesús García-Murria, Gerard Duart, Brayan Grau, Elisabet Diaz-Beneitez, Dolores Rodríguez, Ismael Mingarro and Luis Martínez-Gil. https://www.nature.com/articles/s41467-020-19881-9

ELP-dependent expression of MCL1 promotes resistance to EGFR inhibition in triple-negative breast cancer cells – Peter Cruz-Gordillo, Megan E. Honeywell, Nicholas W. Harper, Thomas Leete, Michael J. Lee. https://stke.sciencemag.org/content/13/658/eabb9820

MCL1 binds and negatively regulates the transcriptional function of tumor suppressor p73 – Hayley Widden, Aneta Kaczmarczyk, Ashok Subedi, Robert H. Whitaker and William J. Placzek. https://www.nature.com/articles/s41419-020-03068-7

Mitofusin 2 but not mitofusin 1 mediates Bcl-XL-induced mitochondrial aggregation – Mengyan Du, Si Yu, Wenhua Su, Mengxin Zhao, Fangfang Yang, Yangpei Liu, Zihao Mai, Yong Wang, Xiaoping Wang and Tongsheng Chen. http://jcs.biologists.org/content/133/20/jcs245001?etoc

Pharmacological targeting of MCL-1 promotes mitophagy and improves disease pathologies in an Alzheimer’s disease mouse model – Xufeng Cen, Yanying Chen, Xiaoyan Xu, Ronghai Wu, Fusheng He, Qingwei Zhao, Qiming Sun, Cong Yi, Jie Wu, Ayaz Najafov and Hongguang Xia. https://www.nature.com/articles/s41467-020-19547-6

BCL-XL is an actionable target for treatment of malignant pleural mesothelioma – Surein Arulananda, Megan O’Brien, Marco Evangelista, Tiffany J. Harris, Nikita S. Steinohrt, Laura J. Jenkins, Marzena Walkiewicz, Robert J. J. O’Donoghue, Ashleigh R. Poh, Bibhusal Thapa, David S. Williams, Trishe Leong, John M. Mariadason, Xia Li, Jonathan Cebon, Erinna F. Lee, Thomas John and W. Douglas Fairlie. https://www.nature.com/articles/s41420-020-00348-1

Taxane-induced Attenuation of the CXCR2/BCL-2 Axis Sensitizes Prostate Cancer to Platinum-based Treatment – Vicenç Ruiz de Porras,  Xieng C. Wang, Luis Palomero, Mercedes Marin-Aguilera, Carme Solé-Blanch, Alberto Indacochea, Natalia Jimenez, Sara Bystrup, Martin Bakht, Vincenza Conteduca, Josep M. Piulats, Oscar Buisan, José F. Suarez, Juan Carlos Pardo, Elena Castro, David Olmos, Himisha Beltran, Begoña Mellado, Eva Martinez-Balibrea, Albert Font, Alvaro Aytes. https://www.europeanurology.com/article/S0302-2838(20)30778-8/fulltext#.X6CQKHJdwUM

Serine-70 phosphorylated Bcl-2 prevents oxidative stress-induced DNA damage by modulating the mitochondrial redox metabolism – Stephen Jun Fei Chong, Kartini Iskandar, Jolin Xiao Hui Lai, Jianhua Qu, Deepika Raman, Rebecca Valentin, Charles Herbaux, Mary Collins, Ivan Cherh Chiet Low, Thomas Loh, Matthew Davids, Shazib Pervaiz. https://academic.oup.com/nar/advance-article/doi/10.1093/nar/gkaa1110/6007660

LncRNA LHFPL3-AS1 contributes to tumorigenesis of melanoma stem cells via the miR-181a-5p/BCL2 pathway – Song Zhang, Haitao Wan and Xiaobo Zhang. https://www.nature.com/articles/s41419-020-03141-1


Death receptors


Inhibition of Glutamine Utilization Synergizes with Immune Checkpoint Inhibitor to Promote Antitumor Immunity – Jun-Kyu Byun, Mihyang Park, Seunghyeong Lee, Jae Won Yun, Jaebon Lee, Jae Sun Kim, Sung Jin Cho, Hui-Jeon Jeon, In-Kyu Lee, Yeon-Kyung Choi, Keun-Gyu Park. https://www.cell.com/molecular-cell/fulltext/S1097-2765(20)30722-X

Tumor Necrosis Factor Receptor-1 (p55) Deficiency Attenuates Tumor Growth and Intratumoral Angiogenesis and Stimulates CD8+ T Cell Function in Melanoma – Rodriguez YI, Campos LE, Castro MG, Bannoud N, Blidner AG, Filippa VP, Croci DO, Rabinovich GA, Alvarez SE. https://www.mdpi.com/2073-4409/9/11/2469


Caspases and IAPs


Caspase-8-dependent gasdermin D cleavage promotes antimicrobial defense but confers susceptibility to TNF-induced lethality – Benjamin Demarco , James P. Grayczyk, Elisabet Bjanes, Didier Le Roy, Wulf Tonnus, Charles-Antoine Assenmacher, Enrico Radaelli, Timothée Fettrelet, Vanessa Mack, Andreas Linkermann, Thierry Roger, Igor E. Brodsky, Kaiwen W. Chen, Petr Broz. https://advances.sciencemag.org/content/6/47/eabc3465

A regulatory region on RIPK2 is required for XIAP binding and NOD signaling activity – Valentin J Heim, Laura F Dagley, Che A Stafford, Fynn M Hansen, Elise Clayer, Aleksandra Bankovacki, Andrew I Webb, Isabelle S Lucet, John Silke, Ueli Nachbur. https://www.embopress.org/doi/abs/10.15252/embr.202050400

Molecular subtype-specific responses of colon cancer cells to the SMAC mimetic Birinapant – Michael Fichtner, Emir Bozkurt, Manuela Salvucci, Christopher McCann, Katherine A. McAllister, Luise Halang, Heiko Düssmann, Sinéad Kinsella, Nyree Crawford, Tamas Sessler, Daniel B. Longley and Jochen H. M. Prehn. https://www.nature.com/articles/s41419-020-03232-z


Necroptosis


Necroptosis restricts influenza A virus as a stand-alone cell death mechanism – Maria Shubina; Bart Tummers; David F. Boyd; Ting Zhang ; Chaoran Yin; Avishekh Gautam; Xi-zhi J. Guo; Diego A. Rodriguez; William J. Kaiser ; Peter Vogel; Douglas R. Green; Paul G. Thomas; Siddharth Balachandran. https://rupress.org/jem/article/217/11/e20191259/152023


Ferroptosis


Vaccination with early ferroptotic cancer cells induces efficient antitumor immunity – Iuliia Efimova, Elena Catanzaro, Louis Van der Meeren, Victoria D Turubanova, Hamida Hammad6, Tatiana A Mishchenko, Maria V Vedunova, Carmela Fimognari, Claus Bachert8, Frauke Coppieters, Steve Lefever, Andre G Skirtach, Olga Krysko and Dmitri V Krysko. https://jitc.bmj.com/content/8/2/e001369

Targeted reduction of cholesterol uptake in cholesterol-addicted lymphoma cells blocks turnover of oxidized lipids to cause ferroptosis – Jonathan S. Rink, Adam Lin, Kaylin M. McMahon, Andrea E Calvert, Shuo Yang, Tim Taxter, Jonathan Moreira, Amy Chadburn, Amir Behdad, Reem Karmali, C. Shad Thaxton and Leo I Gordon. http://www.jbc.org/content/early/2020/11/18/jbc.RA120.014888.abstract


Other forms of cell death


Ionizing radiation results in a mixture of cellular outcomes including mitotic catastrophe, senescence, methuosis, and iron-dependent cell death – Sandy Adjemian, Teodora Oltean, Sofie Martens, Bartosz Wiernicki, Vera Goossens, Tom Vanden Berghe, Benjamin Cappe, Maria Ladik, Franck B. Riquet, Liesbeth Heyndrickx, Jolien Bridelance, Marnik Vuylsteke, Katrien Vandecasteele and Peter Vandenabeele. https://www.nature.com/articles/s41419-020-03209-y


Miscellanous


Akt1 and dCIZ1 promote cell survival from apoptotic caspase activation during regeneration and oncogenic overgrowth – Gongping Sun, Xun Austin Ding, Yewubdar Argaw, Xiaoran Guo and Denise J. Montell. https://www.nature.com/articles/s41467-020-19068-2

Direct Tumor Killing and Immunotherapy through Anti-SerpinB9 Therapy – Liwei Jiang, Yi-Jun Wang, Jing Zhao, Mayuko Uehara, Qingming Hou, Vivek Kasinath, Takaharu Ichimura, Naima Banouni, Li Dai, Xiaofei Li, Dale L. Greiner, Leonard D. Shultz, Xiaolong Zhang, Zhen-Yu Jim Sun, Ian Curtin, Nicholas E. Vangos, Zoe C. Yeoh, Ezekiel A. Geffken, Hyuk-Soo Seo, Ze-Xian Liu, Gregory J. Heffron, Khalid Shah, Sirano Dhe-Paganon, Reza Abdi. https://www.cell.com/cell/fulltext/S0092-8674(20)31452-5

p53 deficiency triggers dysregulation of diverse cellular processes in physiological oxygen – Liz J. Valente; Amy Tarangelo; Albert Mao Li ; Marwan Naciri; Nitin Raj; Anthony M. Boutelle; Yang Li; Stephano Spano Mello ; Kathryn Bieging-Rolett; Ralph J. DeBerardinis; Jiangbin Ye; Scott J. Dixon; Laura D. Attardi. https://rupress.org/jcb/article/219/11/e201908212/152074

The 89-kDa PARP1 cleavage fragment serves as a cytoplasmic PAR carrier to induce AIF-mediated apoptosis – Masato Mashimo, Mayu Onishi, Arina Uno, Akari Tanimichi, Akari Nobeyama, Mana Mori, Sayaka Yamada, Shigeru Negi, Xiangning Bu, Jiro Kato, Joel Moss, Noriko Sanada, Ryoichi Kizu and Takeshi Fujii. http://www.jbc.org/content/early/2020/11/09/jbc.RA120.014479.abstract


Reviews


Targeting Bcl-2 Proteins in Acute Myeloid Leukemia – Yunxiong Wei, Yaqing Cao, Rui Sun, Lin Cheng, Xia Xiong, Xin Jin, Xiaoyuan He, Wenyi Lu, and Mingfeng Zhao. https://www.frontiersin.org/articles/10.3389/fonc.2020.584974/full

Interplay between caspase, Yes-associated protein, and mechanics: A possible switch between life and death? – Jessica Evangeline Tan Kabigting, Yusuke Toyama. https://www.sciencedirect.com/science/article/pii/S0955067420301459

Venetoclax-Based Combinations in Acute Myeloid Leukemia: Current Evidence and Future Directions – Bachar Samra, Marina Konopleva, Alessandro Isidori, Naval Daver, and Courtney DiNardo. https://www.frontiersin.org/articles/10.3389/fonc.2020.562558/full

The function and mechanism of ferroptosis in cancer – Ying Wang, Zihao Wei, Keran Pan, Jing Li, Qianming Chen. https://link.springer.com/article/10.1007/s10495-020-01638-w

TRAIL of Hope Meeting Resistance in Cancer – David Deng, Khalid Shah. https://www.cell.com/trends/cancer/fulltext/S2405-8033(20)30190-4

Detection of immunogenic cell death and its relevance for cancer therapy – Jitka Fucikova, Oliver Kepp, Lenka Kasikova, Giulia Petroni, Takahiro Yamazaki, Peng Liu, Liwei Zhao, Radek Spisek, Guido Kroemer and Lorenzo Galluzzi. https://www.nature.com/articles/s41419-020-03221-2

The caspase-3/GSDME signal pathway as a switch between apoptosis and pyroptosis in cancer – Mingxia Jiang, Ling Qi, Lisha Li and Yanjing Li. https://www.nature.com/articles/s41420-020-00349-0

Targeting BCL-2 in B-cell malignancies and overcoming therapeutic resistance – Isha Kapoor, Juraj Bodo, Brian T. Hill, Eric D. Hsi and Alexandru Almasan. https://www.nature.com/articles/s41419-020-03144-y


Comments


Caspase 2 and p53 Reunited in Tumor Control – Giulia Petroni, Ilio Vitale, Lorenzo Galluzzi. https://www.cell.com/trends/cell-biology/fulltext/S0962-8924(20)30168-9

Caspase-8 protein cuts a brake on immune defences – Igor E. Brodsky. https://www.nature.com/articles/d41586-020-02994-y

The interplay between apoptosis and ferroptosis mediated by ER stress – Go J. Yoshida. https://link.springer.com/article/10.1007/s10495-020-01641-1