ApoList – March 2020

Research is important. Keep strong everyone

 


Death receptors


TRAIL Receptors Serve as Stress-Associated Molecular Patterns to Promote ER-Stress-Induced Inflammation – Graeme P. Sullivan, Hazel O’Connor, Conor M. Henry, Pavel Davidovich, Danielle M. Clancy, Matthew L. Albert, Sean P. Cullen, Seamus J. Martin. https://www.cell.com/developmental-cell/fulltext/S1534-5807(20)30063-0

A20 Promotes Ripoptosome Formation and TNF-Induced Apoptosis via cIAPs Regulation and NIK Stabilization in Keratinocytes – Maria Feoktistova, Roman Makarov, Sihem Brenji, Anne T. Schneider, Guido J. Hooiveld, Tom Luedde, Martin Leverkus, Amir S. Yazdi and Diana Panayotova-Dimitrova. https://www.mdpi.com/2073-4409/9/2/351

Targeting the Extrinsic Pathway of Hepatocyte Apoptosis Promotes Clearance of Plasmodium Liver Infection – Gregor Ebert, Sash Lopaticki, Matthew T. O’Neill, Ryan W.J. Steel, Marcel Doerflinger, Pravin Rajasekaran, Annie S.P. Yang, Sara Erickson, Lisa Ioannidis, Philip Arandjelovic, Liana Mackiewicz, Cody Allison, John Silke, Marc Pellegrini, Justin A. Boddey. https://www.cell.com/cell-reports/fulltext/S2211-1247(20)30346-6


Caspases and cFLIP


Cancer Cells Employ Nuclear Caspase-8 to Overcome the p53-Dependent G2/M Checkpoint through Cleavage of USP28 – Ines Müller, Elwira Strozyk, Sebastian Schindler, Stefan Beissert, Htoo Zarni Oo, Thomas Sauter, Philippe Lucarelli, Sebastian Raeth, Angelika Hausser, Nader Al Nakouzi, Ladan Fazli, Martin E. Gleave, He Liu, Hans-Uwe Simon, Henning Walczak, Douglas R. Green, Jiri Bartek, Mads Daugaard, Dagmar Kulms. https://www.cell.com/molecular-cell/fulltext/S1097-2765(19)30953-0

Cross-regulation between LUBAC and caspase-1 modulates cell death and inflammation – Todd Douglas and Maya Saleh. http://www.jbc.org/content/early/2020/03/02/jbc.RA119.011622.abstract


Gastermins and pyroptosis


Gasdermin E suppresses tumour growth by activating anti-tumour immunity – Zhibin Zhang, Ying Zhang, Shiyu Xia, Qing Kong, Shunying Li, Xing Liu, Caroline Junqueira, Karla F. Meza-Sosa, Temy Mo Yin Mok, James Ansara, Satyaki Sengupta, Yandan Yao, Hao Wu and Judy Lieberman. https://www.nature.com/articles/s41586-020-2071-9

cFLIPL protects macrophages from LPS-induced pyroptosis via inhibition of complex II formation – Hayley I. Muendlein, David Jetton, Wilson M. Connolly, Keith P. Eidell, Zoie Magri, Irina Smirnova, Alexander Poltorak. https://science.sciencemag.org/content/367/6484/1379

A bioorthogonal system reveals antitumour immune function of pyroptosis – Qinyang Wang, Yupeng Wang, Jingjin Ding, Chunhong Wang, Xuehan Zhou, Wenqing Gao, Huanwei Huang, Feng Shao and Zhibo Liu. https://www.nature.com/articles/s41586-020-2079-1

Structural Mechanism for GSDMD Targeting by Autoprocessed Caspases in Pyroptosis – Kun Wang, Qi Sun, Xiu Zhong, Mengxue Zeng, Huan Zeng, Xuyan Shi, Zilin Li, Yupeng Wang, Qiang Zhao, Feng Shao, Jingjin Ding. https://www.cell.com/cell/fulltext/S0092-8674(20)30146-X

Mitochondrial GSDMD Pores DAMPen Pyroptosis – Katherine C. Barnett, Jenny P.-Y. Ting. https://www.cell.com/immunity/fulltext/S1074-7613(20)30083-2

mtDNA Activates cGAS Signaling and Suppresses the YAP-Mediated Endothçelial Cell Proliferation Program to Promote Inflammatory Injury – Long Shuang Huang, Zhigang Hong, Wei Wu, Shiqin Xiong, Ming Zhong, Xiaopei Gao, Jalees Rehman, Asrar B. Malik. https://www.cell.com/immunity/fulltext/S1074-7613(20)30083-2

A bioorthogonal system reveals antitumour immune function of pyroptosis – Qinyang Wang, Yupeng Wang, Jingjin Ding, Chunhong Wang, Xuehan Zhou, Wenqing Gao, Huanwei Huang, Feng Shao and Zhibo Liu. https://www.nature.com/articles/s41586-020-2079-1


Bcl-2 family proteins


A small-molecule allosteric inhibitor of BAX protects against doxorubicin-induced cardiomyopathy – Dulguun Amgalan, Thomas P. Garner, Ryan Pekson, Xiaotong F. Jia, Mounica Yanamandala, Victor Paulino, Felix G. Liang, J. Jose Corbalan, Jaehoon Lee, Yun Chen, George S. Karagiannis, Luis Rivera Sanchez, Huizhi Liang, Swathi-Rao Narayanagari, Kelly Mitchell, Andrea Lopez, Victoria Margulets, Marco Scarlata, Gaetano Santulli, Aarti Asnani, Randall T. Peterson, Rachel B. Hazan, John S. Condeelis, Maja H. Oktay, Ulrich Steidl, Lorrie A. Kirshenbaum, Evripidis Gavathiotis and Richard N. Kitsis. https://www.nature.com/articles/s43018-020-0039-1

Site-Dependent Cysteine Lipidation Potentiates the Activation of Proapoptotic BAX – Daniel T. Cohen, Thomas E. Wales, Matthew W. McHenry, John R. Engen, Loren D. Walensky. https://www.cell.com/cell-reports/fulltext/S2211-1247(20)30225-4

Low expression of pro-apoptotic proteins Bax, Bak and Smac indicates prolonged progression-free survival in chemotherapy-treated metastatic melanoma – Cristiano Guttà, Arman Rahman, Claudia Aura, Peter Dynoodt, Emilie M. Charles, Elodie Hirschenhahn, Jesuchristopher Joseph, Jasper Wouters, Ciaran de Chaumont, Mairin Rafferty, Madhuri Warren, Joost J. van den Oord, William M. Gallagher and Markus Rehm. https://www.nature.com/articles/s41419-020-2309-3

SFTSV Infection Induces BAK/BAX-Dependent Mitochondrial DNA Release to Trigger NLRP3 Inflammasome Activation – Shufen Li, Hao Li, Yu-Lan Zhang, Qi-Lin Xin, Zhen-Qiong Guan, Xi Chen, Xiao-Ai Zhang, Xiao-Kun Li, Geng-Fu Xiao, Pierre-Yves Lozach, Jun Cui, Wei Liu, Lei-Ke Zhang, Ke Peng. https://www.cell.com/cell-reports/fulltext/S2211-1247(20)30286-2

Combined reduction in the expression of MCL-1 and BCL-2 reduces organismal size in mice – Francine Ke, Graeme I. Lancaster, Stephanie Grabow, Andrew J. Murphy and Andreas Strasser. https://www.nature.com/articles/s41419-020-2376-5

MCL1 is Required for Maintenance of Intestinal Homeostasis and Prevention of Carcinogenesis in Mice – Marc E. Healy, Yannick Boege, Michael C. Hodder, Friederike Böhm, Mohsen Malehmir, Anna-Lena Scherr, Jasna Jetzer, Lap Kwan Chan, Rossella Parrotta, Kurt Jacob, Laure-Alix Clerbaux, Susanne Kreutzer, Andrew Campbell, Ella Gilchrist, Kathryn Gilroy, Ann-Katrin Rodewal , Hanna Honcharova-Biletska, Roman Schimmer, Karelia Vélez, Simone Büeler, Patrizia Cammareri , Gabriela Kalna, Anna S. Wenning, Kathy D. McCoy, Mercedes Gomez de Agüero, Henning Schulze-Bergkamen, Christoph Klose, Kristian Unger, Andrew J. Macpherson , Andreas E. Moor, Bruno Köhler, Owen J. Sanso, Mathias Heikenwalder, Achim Weber. https://www.gastrojournal.org/article/S0016-5085(20)30338-3/fulltext

HUWE1 controls MCL1 stability to unleash AMBRA1-induced mitophagyFlavie Strappazzon, Anthea Di Rita, Angelo Peschiaroli, Pier Paolo Leoncini, Franco Locatelli, Gerry Melino and Francesco Cecconi. https://www.nature.com/articles/s41418-019-0404-8

MCL1 binding to the reverse BH3 motif of P18INK4C couples cell survival to cell proliferation – Robert H. Whitaker and William J. Placzek. https://www.nature.com/articles/s41419-020-2351-1

MCL1 inhibition is effective against a subset of small-cell lung cancer with high MCL1 and low BCL-XL expression – Yuto Yasuda, Hiroaki Ozasa, Young Hak Kim, Masatoshi Yamazoe, Hitomi Ajimizu, Tomoko Yamamoto Funazo, Takashi Nomizo, Takahiro Tsuji, Hironori Yoshida, Yuichi Sakamori, Naoki Nakajima, Toshi Menju, Akihiko Yoshizawa, Hiroshi Date and Toyohiro Hirai. https://www.nature.com/articles/s41419-020-2379-2

Conformational Switching in Bcl-xL: Enabling Non-Canonic Inhibition of Apoptosis Involves Multiple Intermediates and Lipid Interactions – Victor Vasquez-Montes, Alexander Kyrychenko, Mauricio Vargas-Uribe, Mykola V. Rodnin and Alexey S. Ladokhin. https://www.mdpi.com/2073-4409/9/3/539

Electron transport chain activity is a predictor and target for venetoclax sensitivity in multiple myeloma – Richa Bajpai, Aditi Sharma, Abhinav Achreja, Claudia L. Edgar, Changyong Wei, Arusha A. Siddiqa, Vikas A. Gupta, Shannon M. Matulis, Samuel K. McBrayer, Anjali Mittal, Manali Rupji, Benjamin G. Barwick, Sagar Lonial, Ajay K. Nooka, Lawrence H. Boise, Deepak Nagrath and Mala Shanmugam. https://www.nature.com/articles/s41467-020-15051-z


Necroptosis


Sequential activation of necroptosis and apoptosis cooperates to mediate vascular and neural pathology in stroke – Masanori Gomi Naito, Daichao Xu, Palak Amin, Jinwoo Lee, Huibing Wang, Wanjin Li, Michelle Kelliher, Manolis Pasparakis, and Junying Yuan. https://www.pnas.org/content/117/9/4959.abstract?etoc

Z-nucleic-acid sensing triggers ZBP1-dependent necroptosis and inflammation – Huipeng Jiao, Laurens Wachsmuth, Snehlata Kumari, Robin Schwarzer, Juan Lin, Remzi Onur Eren, Amanda Fisher, Rebecca Lane, George R. Young, George Kassiotis, William J. Kaiser and Manolis Pasparakis. https://www.nature.com/articles/s41586-020-2129-8

Gut stem cell necroptosis by genome instability triggers bowel inflammation – Ruicong Wang, Hongda Li, Jianfeng Wu, Zhi-Yu Cai, Baizhou Li, Hengxiao Ni, Xingfeng Qiu, Hui Chen, Wei Liu, Zhang-Hua Yang, Min Liu, Jin Hu, Yaoji Liang, Ping Lan, Jiahuai Han and Wei Mo. https://www.nature.com/articles/s41586-020-2127-x

Inhibition of keratinocyte necroptosis mediated by RIPK1/RIPK3/MLKL provides a protective effect against psoriatic inflammation – Xiaoru Duan, Xinxin Liu, Nian Liu, Yuqiong Huang, Zilin Jin, Song Zhang, Zhangyin Ming and Hongxiang Chen. https://www.nature.com/articles/s41419-020-2328-0

Necroptosis-blocking compound NBC1 targets heat shock protein 70 to inhibit MLKL polymerization and necroptosis – Andrea N. Johnston, Yuyong Ma, Hua Liu, Shuzhen Liu, Sarah Hanna-Addams, She Chen, Chuo Chen and Zhigao Wang. https://www.pnas.org/content/117/12/6521.abstract?etoc

Influenza Virus Z-RNAs Induce ZBP1-Mediated Necroptosis – Ting Zhang, Chaoran Yin, David F. Boyd, Giovanni Quarato, Justin P. Ingram, Maria Shubina, Katherine B. Ragan, Takumi Ishizuka, Jeremy Chase Crawford, Bart Tummers, Diego A. Rodriguez, Jia Xue, Suraj Peri, William J. Kaiser, Carolina B. López, Yan Xu, Jason W. Upton, Paul G. Thomas, Douglas R. Green, Siddharth Balachandran. https://www.cell.com/cell/fulltext/S0092-8674(20)30227-0

The necroptosis machinery mediates axonal degeneration in a model of Parkinson diseaseMaritza Oñate, Alejandra Catenaccio, Natalia Salvadores, Cristian Saquel, Alexis Martinez, Ines Moreno-Gonzalez, Nazaret Gamez, Paulina Soto, Claudio Soto, Claudio Hetz and Felipe A. Court. https://www.nature.com/articles/s41418-019-0408-4


Ferroptosis


Transferrin Receptor Is a Specific Ferroptosis Marker – Huizhong Feng, Kenji Schorpp, Jenny Jin, Carrie E. Yozwiak, Benjamin G. Hoffstrom, Aubrianna M. Decker, Presha Rajbhandari, Michael E. Stokes, Hannah G. Bender, Joleen M. Csuka, Pavan S. Upadhyayula, Peter Canoll, Koji Uchida, Rajesh K. Soni, Kamyar Hadian, Brent R. Stockwell. https://www.cell.com/cell-reports/fulltext/S2211-1247(20)30210-2

Mitochondrial DNA stress triggers autophagy-dependent ferroptotic death – Li C, Zhang Y, Liu J, Kang R, Klionsky DJ, Tang D. https://www.tandfonline.com/doi/full/10.1080/15548627.2020.1739447

Caspase-1 interdomain linker cleavage is required for pyroptosis – Daniel P Ball, Cornelius Y Taabazuing, Andrew R Griswold, Elizabeth L Orth, Sahana D Rao, Ilana B Kotliar, Lauren E Vostal, Darren C Johnson and Daniel A Bachovchin. https://www.life-science-alliance.org/content/3/3/e202000664.abstract


Efferocytosis and cell-cell effects


Metabolites released from apoptotic cells act as tissue messengers – Christopher B. Medina, Parul Mehrotra, Sanja Arandjelovic, Justin S. A. Perry, Yizhan Guo, Sho Morioka, Brady Barron, Scott F. Walk, Bart Ghesquière, Alexander S. Krupnick, Ulrike Lorenz and Kodi S. Ravichandran. https://www.nature.com/articles/s41586-020-2121-3

Macrophage Metabolism of Apoptotic Cell-Derived Arginine Promotes Continual Efferocytosis and Resolution of Injury – Arif Yurdagul Jr., Manikandan Subramanian, Xiaobo Wang, Scott B. Crown, Olga R. Ilkayeva, Lancia Darville, Gopi K. Kolluru, Christina C. Rymond, Brennan D. Gerlach, Ze Zheng, George Kuriakose, Christopher G. Kevil, John M. Koomen, John L. Cleveland, Deborah M. Muoio, Ira Tabas. https://www.sciencedirect.com/science/article/abs/pii/S1550413120300012


Miscellanous


In vivo detection of programmed cell death during mouse heart development – Kristel Martínez-Lagunas, Yoshifumi Yamaguchi, Cora Becker, Caroline Geisen, Marco C. DeRuiter, Masayuki Miura, Bernd K. Fleischmann and Michael Hesse. https://www.nature.com/articles/s41418-019-0426-2


Reviews


Classification and Nomenclature of Metacaspases and Paracaspases: No More Confusion with Caspases – Elena A. Minina, Jens Staal, Vanina E. Alvarez, John A. Berges, Ilana Berman-Frank, Rudi Beyaert, Kay D. Bidle, Frédéric Bornancin, Magali Casanova, Juan J. Cazzulo, Chang Jae Choi, Nuria S. Coll, Vishva M. Dixit, Marko Dolinar, Nicolas Fasel, Christiane Funk, Patrick Gallois, Kris Gevaert, Emilio Gutierrez-Beltran, Stephan Hailfinger, Marina Klemenčič, Eugene V. Koonin, Daniel Krappmann, Anna Linusson, Maurício F.M. Machado, Frank Madeo, Lynn A. Megeney, Panagiotis N. Moschou, Jeremy C. Mottram, Thomas Nyström, Heinz D. Osiewacz, Christopher M. Overall, Kailash C. Pandey, Jürgen Ruland, Guy S. Salvesen, Yigong Shi, Andrei Smertenko, Simon Stael, Jerry Ståhlberg, María Fernanda Suárez, Margot Thome, Hannele Tuominen, Frank Van Breusegem, Renier A.L. van der Hoorn, Assaf Vardi, Boris Zhivotovsky, Eric Lam, Peter V. Bozhkov. https://www.cell.com/molecular-cell/fulltext/S1097-2765(19)30950-5

Investigating Nonapoptotic Cell Death Using Chemical Biology Approaches – David A. Armenta, Scott J. Dixon. https://www.cell.com/cell-chemical-biology/fulltext/S2451-9456(20)30079-9

Ferroptosis: past, present and future – Jie Li, Feng Cao, He-liang Yin, Zi-jian Huang, Zhi-tao Lin, Ning Mao, Bei Sun and Gang Wang. https://www.nature.com/articles/s41419-020-2298-2

Restoring Apoptosis with BH3 Mimetics in Mature B-Cell Malignancies – Maxime Jullien, Patricia Gomez-Bougie, David Chiron and Cyrille Touzeau. https://www.mdpi.com/2073-4409/9/3/717


Comments


Ghostly metabolic messages from dying cells – Douglas R. Green. https://www.nature.com/articles/d41586-020-00641-0

ER Stress Leaves an Inflammatory TRAIL – Alba Roca Portoles, Stephen W.G. Tait. https://www.cell.com/developmental-cell/fulltext/S1534-5807(20)30188-X

Appetite for Arginine: Metabolic Control of Macrophage Hunger – Daniel J. Puleston, Erika L. Pearce. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(20)30064-4

TAMing efferocytosis to fight tumors – Christopher B. Rodell. https://stm.sciencemag.org/content/12/533/eabb0795

Destroying tumors with pyroptosis – John F. Foley. https://stke.sciencemag.org/content/13/624/eabb8244

ApoList – February 2020

Dear all,

Please allow me to advertise this service in case you want to do your personalized ApoList, or a weekly list of interesting articles on any topic. Biomed News (www.biomed.news) proposes you new records in PubMed every week, ranked by machine learning. You select your favorite items, they are sent to you via email, and you can then disseminate the weekly list yourself. Other users can browse it at  http://biomed.news/reports

Regards,

Cris


Bcl-2 family proteins


STING-dependent paracriny shapes apoptotic priming of breast tumors in response to anti-mitotic treatment – Steven Lohard, Nathalie Bourgeois, Laurent Maillet, Fabien Gautier, Aurélie Fétiveau, Hamza Lasla, Frédérique Nguyen, Céline Vuillier, Alison Dumont, Agnès Moreau-Aubry, Morgane Frapin, Laurent David, Delphine Loussouarn, Olivier Kerdraon, Mario Campone, Pascal Jézéquel, Philippe P. Juin and Sophie Barillé-Nion. https://www.nature.com/articles/s41467-019-13689-y

Allosteric Regulation of BH3 Proteins in Bcl-xL Complexes Enables Switch-like Activation of Bax – Christian Bogner, Justin Kale, Justin Pogmore, Xiaoke Chi, Aisha Shamas-Din, Cécile Fradin, Brian Leber, David W. Andrews. https://www.cell.com/molecular-cell/fulltext/S1097-2765(19)30955-4

A selective BCL-XL PROTAC degrader achieves safe and potent antitumor activity – Sajid Khan, Xuan Zhang, Dongwen Lv, Qi Zhang, Yonghan He, Peiyi Zhang, Xingui Liu, Dinesh Thummuri, Yaxia Yuan, Janet S. Wiegand, Jing Pei, Weizhou Zhang, Abhisheak Sharma, Christopher R. McCurdy, Vinitha M. Kuruvilla, Natalia Baran, Adolfo A. Ferrando, Yong-mi Kim, Anna Rogojina, Peter J. Houghton, Guangcun Huang, Robert Hromas, Marina Konopleva, Guangrong Zheng and Daohong Zhou. https://www.nature.com/articles/s41591-019-0668-z

Overexpression of Antiapoptotic MCL-1 Predicts Worse Overall Survival of Patients With Non-small Cell Lung Cancer – Nakano T, Go T, Nakashima N, Liu D, Yokomise H. http://ar.iiarjournals.org/content/40/2/1007.abstract

Potent efficacy of MCL-1 inhibitor-based therapies in preclinical models of mantle cell lymphoma – Michael A. Dengler, Charis E. Teh, Rachel Thijssen, Lahiru Gangoda, Ping Lan, Marco J. Herold, Daniel H. Gray, Gemma L. Kelly, Andrew W. Roberts and Jerry M. Adams. https://www.nature.com/articles/s41388-019-1122-x

Aurora A Kinase Inhibition Destabilizes PAX3-FOXO1 and MYCN and Synergizes with Navitoclax to Induce Rhabdomyosarcoma Cell Death – Johannes Ommer, Joanna L. Selfe, Marco Wachtel, Eleanor M. O’Brien, Dominik Laubscher, Michaela Roemmele, Stephanie Kasper, Olivier Delattre, Didier Surdez, Gemma Petts, Anna Kelsey, Janet Shipley and Beat W. Schäfer. https://cancerres.aacrjournals.org/content/80/4/832

MCL-1 antagonism enhances the anti-invasive effects of dasatinib in pancreatic adenocarcinoma – Lesley Castillo, Adelaide I. J. Young, Amanda Mawson, Pia Schafranek, Angela M. Steinmann, Danielle Nessem, Ashleigh Parkin, Amber Johns, Angela Chou, Andrew M. K. Law, Morghan C. Lucas, Kendelle J. Murphy, Niantao Deng, David Gallego-Ortega, Catherine E. Caldon, Australian Pancreatic Cancer Genome Initiative (APGI), Paul Timpson, Marina Pajic, Christopher J. Ormandy and Samantha R. Oakes. https://www.nature.com/articles/s41388-019-1091-0

Dynamic PGAM5 multimers dephosphorylate BCL-xL or FUNDC1 to regulate mitochondrial and cellular fate – Kaili Ma, Zhi Zhang, Rui Chang, Hongcheng Cheng, Chenglong Mu, Tian Zhao, Linbo Chen, Chuanmei Zhang, Qian Luo, Jialing Lin, Yushan Zhu and Quan Chen. https://www.nature.com/articles/s41418-019-0396-4


Death receptors


Long and short isoforms of c-FLIP act as control checkpoints of DED filament assembly – Laura K. Hillert, Nikita V. Ivanisenko, Johannes Espe, Corinna König, Vladimir A. Ivanisenko, Thilo Kähne and Inna N. Lavrik. https://www.nature.com/articles/s41388-019-1100-3

The parkin-coregulated gene product PACRG promotes TNF signaling by stabilizing LUBAC – Jens Meschede , Maria Šadić, Nikolas Furthmann, Tim Miedema, Dominik A. Sehr, A. Kathrin Müller-Rischart, Verian Bader, Lena A. Berlemann, Anna Pilsl, Anita Schlierf, Katalin Barkovits, Barbara Kachholz, Katrin Rittinger, Fumiyo Ikeda, Katrin Marcus, Liliana Schaefer, Jörg Tatzelt, Konstanze F. Winklhofer. https://stke.sciencemag.org/content/13/617/eaav1256

Cell death induced by the ER stressor thapsigargin involves death receptor 5, a non-autophagic function of MAP1LC3B, and distinct contributions from unfolded protein response components – Lindner P, Christensen SB, Nissen P, Møller JV, Engedal N. https://biosignaling.biomedcentral.com/articles/10.1186/s12964-019-0499-z

OTULIN Prevents Liver Inflammation and Hepatocellular Carcinoma by Inhibiting FADD- and RIPK1 Kinase-Mediated Hepatocyte Apoptosis – Lien Verboom, Arne Martens, Dario Priem, Esther Hoste, Mozes Sze, Hanna Vikkula, Lisette Van Hove, Sofie Voet, Jana Roels, Jonathan Maelfait, Laura Bongiovanni, Alain de Bruin, Charlotte L. Scott, Yvan Saeys, Manolis Pasparakis, Mathieu J.M. Bertrand, Geert van Loo. https://www.cell.com/cell-reports/fulltext/S2211-1247(20)30037-1


Caspases


E2F-Family Members Engage the PIDDosome to Limit Hepatocyte Ploidy in Liver Development and Regeneration – Valentina C. Sladky, Katja Knapp, Claudia Soratroi, Julia Heppke, Felix Eichin, Lourdes Rocamora-Reverte, Tamas G. Szabo, Laura Bongiovanni, Bart Westendorp, Eva Moreno, Elsbeth A. van Liere, Bjorn Bakker, Diana C.J. Spierings, René Wardenaar, David Pereyra, Patrick Starlinger, Simon Schultze, Michael Trauner, Tatjana Stojakovic, Hubert Scharnagl, Luca L. Fava, Floris Foijer, Alain de Bruin, Andreas Villunger. https://www.cell.com/developmental-cell/fulltext/S1534-5807(19)31039-1

Opposing effects of polysulfides and thioredoxin on apoptosis through caspase persulfidation – Ilana Braunstein, Rotem Engelman, Ofer Yitzhaki, Tamar Ziv, Erwan Galardon and Moran Benhar. http://www.jbc.org/content/early/2020/02/10/jbc.RA119.012357.abstract

An AMPK–caspase-6 axis controls liver damage in nonalcoholic steatohepatitis – Peng Zhao, Xiaoli Sun, Cynthia Chaggan, Zhongji Liao, Kai in Wong, Feng He, Seema Singh, Rohit Loomba, Michael Karin, Joseph L. Witztum, Alan R. Saltiel. https://science.sciencemag.org/content/367/6478/652


Necroptosis and RIP kinases


RIP1 kinase activity is critical for skin inflammation but not for viral propagation – Joshua D. Webster  Youngsu C. Kwon  Summer Park  Hua Zhang  Nick Corr  Nina Ljumanovic  Adeyemi O. Adedeji  Eugene Varfolomeev  Tatiana Goncharov  Jessica Preston  Sara F. Santagostino  Snahel Patel  Min Xu  Jonathan Maher  Brent S. McKenzie  Domagoj Vucic. https://jlb.onlinelibrary.wiley.com/doi/full/10.1002/JLB.3MA1219-398R

Phenotypic high-throughput screening platform identifies novel chemotypes for necroptosis inhibition – Hugo Brito, Vanda Marques, Marta B. Afonso, Dean G. Brown, Ulf Börjesson, Nidhal Selmi, David M. Smith, Ieuan O. Roberts, Martina Fitzek, Natália Aniceto, Rita C. Guedes, Rui Moreira and Cecília M. P. Rodrigues. https://www.nature.com/articles/s41420-020-0240-0


Ferroptosis


Energy-stress-mediated AMPK activation inhibits ferroptosis – Hyemin Lee, Fereshteh Zandkarimi, Yilei Zhang, Jitendra Kumar Meena, Jongchan Kim, Li Zhuang, Siddhartha Tyagi, Li Ma, Thomas F. Westbrook, Gregory R. Steinberg, Daisuke Nakada, Brent R. Stockwell and Boyi Gan. https://www.nature.com/articles/s41556-020-0461-8


Miscellanous


Cell Death in Cells Overlying Lateral Root Primordia Facilitates Organ Growth in Arabidopsis – Sacha Escamez, Domenique André, Bernadette Sztojka, Benjamin Bollhöner, Hardy Hall, Béatrice Berthet, Ute Voß, Amnon Lers, Alexis Maizel, Magnus Andersson, Malcolm Bennett, Hannele Tuominen. https://www.cell.com/current-biology/fulltext/S0960-9822(19)31580-5

Coordinated changes in cell membrane and cytoplasm during maturation of apoptotic bleb – Kana Aoki, Shinsuke Satoi, Shota Harada, Seiichi Uchida, Yoh Iwasa, and Junichi Ikenouchi. https://www.molbiolcell.org/doi/10.1091/mbc.E19-12-0691?ai=25zg&ui=2oy6&af=T

Control of cell death/survival balance by the MET dependence receptor – Leslie Duplaquet, Catherine Leroy, Audrey Vinchent, Sonia Paget, Jonathan Lefebvre, Fabien Vanden Abeele, Steve Lancel, Florence Giffard, Réjane Paumelle, Gabriel Bidaux, Laurent Heliot, Laurent Poulain, Alessandro Furlan, David Tulasne. https://elifesciences.org/articles/50041


Reviews


RIPK1 Kinase-Dependent Death: A Symphony of Phosphorylation Events – Tom Delanghe, Yves Dondelinger, Mathieu J.M. Bertrand. https://www.cell.com/trends/cell-biology/fulltext/S0962-8924(19)30223-5

SMAC mimetics and RIPK inhibitors as therapeutics for chronic inflammatory diseases – Simone Jensen, Jakob Benedict Seidelin, Eric Charles LaCasse, and Ole Haagen Nielsen. https://stke.sciencemag.org/content/13/619/eaax8295


Comments


Mechanisms for Ca2+-dependent permeability transition in mitochondria – Paolo Bernardi. https://www.pnas.org/content/117/6/2743?etoc=

Reply to Bernardi: The mitochondrial permeability transition pore and the ATP synthase – John E. Walker, Joe Carroll, and Jiuya He. https://www.pnas.org/content/117/6/2745

Loss of ferritin in developing wing cells: Apoptosis and ferroptosis coincide – Anna Karen Hernández-Gallardo, Fanis Missirlis. https://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1008503

The PROTAC DT2216 Targets Cancer by Promoting BCL-XL Degradation – https://cancerdiscovery.aacrjournals.org/content/10/2/174.1

ApoList – January 2020


Immunogenicity of cell death


Quantitative and Dynamic Catalogs of Proteins Released during Apoptotic and Necroptotic Cell Death – Maria C. Tanzer, Annika Frauenstein, Che A. Stafford, Kshiti Phulphagar, Matthias Mann, Felix Meissner. https://www.cell.com/cell-reports/fulltext/S2211-1247(19)31744-9

Immunodominant AH1 Antigen-Deficient Necroptotic, but Not Apoptotic, Murine Cancer Cells Induce Antitumor Protection – Tania Løve Aaes, Hanne Verschuere, Agnieszka Kaczmarek, Liesbeth Heyndrickx, Bartosz Wiernicki, Iris Delrue, Bram De Craene, Joachim Taminau, Tinneke Delvaeye, Mathieu J. M. Bertrand, Wim Declercq, Geert Berx, Dmitri V. Krysko, Sandy Adjemian and Peter Vandenabeele. https://www.jimmunol.org/content/early/2020/01/02/jimmunol.1900072

Immune Sensing of Cell Death through Recognition of Histone Sequences by C-Type Lectin-Receptor-2d Causes Inflammation and Tissue Injury – Jiann-Jyh Lai, Freidrich M. Cruz, Kenneth L. Rock. https://www.cell.com/immunity/fulltext/S1074-7613(19)30494-7

Characterization of virus-mediated immunogenic cancer cell death and the consequences for oncolytic virus-based immunotherapy of cancer – Jing Ma, Mohanraj Ramachandran, Chuan Jin, Clara Quijano-Rubio, Miika Martikainen, Di Yu and Magnus Essand. https://www.nature.com/articles/s41419-020-2236-3


Death receptors


Misfolded proteins bind and activate death receptor 5 to induce apoptosis during unresolved endoplasmic reticulum stress – Mable Lam, Scot A Marsters, Avi Ashkenazi, Peter Walter. https://elifesciences.org/articles/52291

Heterogeneous responses to low level death receptor activation are explained by random molecular assembly of the Caspase-8 activation platform – Matveeva A, Fichtner M, McAllister K, McCann C, Sturrock M, Longley DB, Prehn JHM. https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1007374

Single-molecule imaging reveals the oligomeric state of functional TNFα-induced plasma membrane TNFR1 clusters in cells – Christos Karathanasis, Juliane Medler, Franziska Fricke, Sonja Smith, Sebastian Malkusch, Darius Widera, Simone Fulda, Harald Wajant, Sjoerd J. L. van Wijk, Ivan Dikic and Mike Heilemann. https://stke.sciencemag.org/content/13/614/eaax5647


Bcl-2 family proteins


Mitochondrial residence of the apoptosis inducer BAX is more important than BAX oligomerization in promoting membrane permeabilization – Tomomi Kuwana, Louise E King, Katia Cosentino, Julian Suess, Ana J. García-Sáez, Andrew P. Gilmore and Donald D Newmeyer. http://www.jbc.org/content/early/2020/01/03/jbc.RA119.011635.abstract

Dynein light chain binding determines complex formation and posttranslational stability of the Bcl-2 family members Bmf and Bim – Prafull Kumar Singh, Aristomenis Roukounakis, Arnim Weber, Kushal Kumar Das, Benedicte Sohm, Andreas Villunger, Ana J. Garcia-Saez and Georg Häcker. https://www.nature.com/articles/s41418-019-0365-y

Loss of Bcl-G, a Bcl-2 family member, augments the development of inflammation-associated colorectal cancer – Paul M. Nguyen, Laura F. Dagley, Adele Preaudet, Nga Lam, Maybelline Giam, Ka Yee Fung, Kaheina Aizel, Gemma van Duijneveldt, Chin Wee Tan, Yumiko Hirokawa, Hon Yan K. Yip, Christopher G. Love, Ashleigh R. Poh, Akshay D’ Cruz, Charlotte Burstroem, Rebecca Feltham, Suad M. Abdirahman, Kristy Meiselbach, Ronnie Ren Jie Low, Michelle Palmieri, Matthias Ernst, Andrew I. Webb, Tony Burgess, Oliver M. Sieber, Philippe Bouillet and Tracy L. Putoczki. https://www.nature.com/articles/s41418-019-0383-9

Human BCL-G regulates secretion of inflammatory chemokines but is dispensable for induction of apoptosis by IFN-γ and TNF-α in intestinal epithelial cells – Jerzy A. Woznicki, Peter Flood, Milan Bustamante-Garrido, Panagiota Stamou, Gerry Moloney, Aine Fanning, Syed Akbar Zulquernain, Jane McCarthy, Fergus Shanahan, Silvia Melgar and Ken Nally. https://www.nature.com/articles/s41419-020-2263-0

Characterization of a novel human BFL-1-specific monoclonal antibody – Lahiru Gangoda, Charis E. Teh, Michael A. Dengler, Sarah A. Best, Clare E. Weeden, Lin Tai, Erinna F. Lee, Walter D. Fairlie, Kate D. Sutherland, Leonard C. Harrison, Daniel H. Gray, Andreas Strasser and Marco J. Herold. https://www.nature.com/articles/s41418-019-0454-y

Bile acid-induced “Minority MOMP” promotes esophageal carcinogenesis while maintaining apoptotic resistance via Mcl-1 – Yuan Xu, Deborah R. Surman, Laurence Diggs, Sichuan Xi, Shaojian Gao, Devikala Gurusamy, Kaitlin McLoughlin, Justin Drake, Paul Feingold, Kate Brown, Danny Wangsa, Darawalee Wangsa, Xi Zhang, Thomas Ried, Jeremy L. Davis, Jonathan Hernandez, Chuong D. Hoang, Rhonda F. Souza, David S. Schrump and R. Taylor Ripley. https://www.nature.com/articles/s41388-019-1029-6

The carboxyl-terminal sequence of bim enables bax activation and killing of unprimed cells – Xiaoke Chi, Dang Nguyen, James M Pemberton, Elizabeth J Oesterlund, Qian Liu, Hetal Brahmbhatt, Zhi Zhang, Jialing Lin, Brian Leber, David W Andrews. https://elifesciences.org/articles/44525

Type 1 Innate Lymphoid Cells Protect Mice from Acute Liver Injury via Interferon-γ Secretion for Upregulating Bcl-xL Expression in Hepatocytes – Tsukasa Nabekura, Luke Riggan, Andrew D. Hildreth, Timothy E. O’Sullivan, Akira Shibuya. https://www.cell.com/immunity/fulltext/S1074-7613(19)30462-5


Caspases


Exploring the prime site in caspases as a novel chemical strategy for understanding the mechanisms of cell death: a proof of concept study on necroptosis in cancer cells – Katarzyna Groborz, Monica L. Gonzalez Ramirez, Scott J. Snipas, Guy S. Salvesen, Marcin Drąg and Marcin Poręba. https://www.nature.com/articles/s41418-019-0364-z


Necroptosis / RIP kinases


CK1α, CK1δ, and CK1ε are necrosome components which phosphorylate serine 227 of human RIPK3 to activate necroptosis – Sarah Hanna-Addams, Shuzhen Liu, Hua Liu, She Chen and Zhigao Wang. https://www.pnas.org/content/117/4/1962.abstract?etoc

Casein kinase-1γ1 and 3 stimulate tumor necrosis factor-induced necroptosis through RIPK3 – Song-Yi Lee, Hyunjoo Kim, Cathena Meiling Li, Jaemin Kang, Ayaz Najafov, Muhah Jung, Soosung Kang, Shaomeng Wang, Junying Yuan and Yong-Keun Jung. https://www.nature.com/articles/s41419-019-2146-4

Constitutive Interferon Attenuates RIPK1/3-Mediated Cytokine Translation – Hayley I. Muendlein, Joseph Sarhan, Beiyun C. Liu, Wilson M. Connolly, Stephen A. Schworer, Irina Smirnova, Amy Y. Tang, Vladimir Ilyukha, Jodie Pietruska, Soroush Tahmasebi, Nahum Sonenberg, Alexei Degterev, Alexander Poltorak. https://www.cell.com/cell-reports/fulltext/S2211-1247(19)31730-9

Resolvin D1 promotes the targeting and clearance of necroptotic cells – Brennan D. Gerlach, Michael Marinello, Justin Heinz, Nicholas Rymut, Brian E. Sansbury, Colin O. Riley, Sudeshna Sadhu, Zeinab Hosseini, Yoko Kojima, Dale D. Tang, Nicholas J. Leeper, Matthew Spite, Margarida Barroso, Katey J. Rayner and Gabrielle Fredman. https://www.nature.com/articles/s41418-019-0370-1


Ferroptosis


ATF3 promotes erastin-induced ferroptosis by suppressing system Xc – Liyuan Wang, Yichen Liu, Tingting Du, Heng Yang, Lei Lei, Mengqi Guo, Han-Fei Ding, Junran Zhang, Hongbo Wang, Xiaoguang Chen and Chunhong Yan. https://www.nature.com/articles/s41418-019-0380-z


Miscellanous


Programmed cell death along the midline axis patterns ipsilaterality in gastrulation – Lisandro Maya-Ramos, Takashi Mikawa. https://science.sciencemag.org/content/367/6474/197

Nuclear degradation dynamics in a nonapoptotic programmed cell death – Alla Yalonetskaya, Albert A. Mondragon, Zackary J. Hintze, Susan Holmes and Kimberly McCall. https://www.nature.com/articles/s41418-019-0382-x


Reviews


Mitochondria as multifaceted regulators of cell death – Florian J. Bock and Stephen W. G. Tait. https://www.nature.com/articles/s41580-019-0173-8

Beyond inflammasomes: emerging function of gasdermins during apoptosis and NETosis – Kaiwen W Chen, Benjamin Demarco, Petr Broz. https://www.embopress.org/doi/abs/10.15252/embj.2019103397

Immunological impact of cell death signaling driven by radiation on the tumor microenvironment – Maria Esperanza Rodriguez-Ruiz, Ilio Vitale, Kevin J. Harrington, Ignacio Melero and Lorenzo Galluzzi. https://www.nature.com/articles/s41590-019-0561-4

Saga of Mcl-1: regulation from transcription to degradation – Viacheslav V. Senichkin, Alena Y. Streletskaia, Anna S. Gorbunova, Boris Zhivotovsky and Gelina S. Kopeina. https://www.nature.com/articles/s41418-019-0486-3


Comments


A matter of life and death for caspase 8 – Joseph Willson. https://www.nature.com/articles/s41580-019-0201-8

Clec2d Joins the Cell Death Sensor Ranks – Carlos del Fresno, David Sancho. https://www.cell.com/immunity/fulltext/S1074-7613(19)30534-5

 

ApoList – December 2019


Caspases and IAPs


Mutations that prevent caspase cleavage of RIPK1 cause autoinflammatory disease – Najoua Lalaoui, Steven E. Boyden, Hirotsugu Oda, Geryl M. Wood, Deborah L. Stone, Diep Chau, Lin Liu, Monique Stoffels, Tobias Kratina, Kate E. Lawlor, Kristien J. M. Zaal, Patrycja M. Hoffmann, Nima Etemadi, Kristy Shield-Artin, Christine Biben, Wanxia Li Tsai, Mary D. Blake, Hye Sun Kuehn, Dan Yang, Holly Anderton, Natasha Silke, Laurens Wachsmuth, Lixin Zheng, Natalia Sampaio Moura, David B. Beck, Gustavo Gutierrez-Cruz, Amanda K. Ombrello, Gineth P. Pinto-Patarroyo, Andrew J. Kueh, Marco J. Herold, Cathrine Hall, Hongying Wang, Jae Jin Chae, Natalia I. Dmitrieva, Mark McKenzie, Amanda Light, Beverly K. Barham, Anne Jones, Tina M. Romeo, Qing Zhou, Ivona Aksentijevich, James C. Mullikin, Andrew J. Gross, Anthony K. Shum, Edwin D. Hawkins, Seth L. Masters, Michael J. Lenardo, Manfred Boehm, Sergio D. Rosenzweig, Manolis Pasparakis, Anne K. Voss, Massimo Gadina, Daniel L. Kastner and John Silke. https://www.nature.com/articles/s41586-019-1828-5

A dominant autoinflammatory disease caused by non-cleavable variants of RIPK1 – Panfeng Tao, Jinqiao Sun, Zheming Wu, Shihao Wang, Jun Wang, Wanjin Li, Heling Pan, Renkui Bai, Jiahui Zhang, Ying Wang, Pui Y. Lee, Wenjing Ying, Qinhua Zhou, Jia Hou, Wenjie Wang, Bijun Sun, Mi Yang, Danru Liu, Ran Fang, Huan Han, Zhaohui Yang, Xin Huang, Haibo Li, Natalie Deuitch, Yuan Zhang, Dilan Dissanayake, Katrina Haude, Kirsty McWalter, Chelsea Roadhouse, Jennifer J. MacKenzie, Ronald M. Laxer, Ivona Aksentijevich, Xiaomin Yu, Xiaochuan Wang, Junying Yuan and Qing Zhou. https://www.nature.com/articles/s41586-019-1830-y

Cleaved Caspase-3 Transcriptionally Regulates Angiogenesis-Promoting Chemotherapy Resistance – Antoine Bernard, Sandy Chevrier, Françoise Beltjens, Magalie Dosset, Etienne Viltard, Anaïs Lagrange, Valentin Derangère, Alexandra Oudot, François Ghiringhelli, Bertrand Collin, Lionel Apetoh, Olivier Feron, Suzie Chen, Laurent Arnould, Frédérique Végran and Romain Boidot. https://cancerres-aacrjournals-org.sire.ub.edu/content/79/23/5958

Modulation of the extrinsic cell death signaling pathway by viral Flip induces acute-death mediated liver failure – Miriam Bittel, Andreas E. Kremer, Michael Stürzl, Stefan Wirtz, Iris Stolzer, Markus F. Neurath, Gianna Ballon and Claudia Günther. https://www.nature.com/articles/s41419-019-2115-y

CASP9 (caspase 9) is essential for autophagosome maturation through regulation of mitochondrial homeostasis – Hyun-Kyu An, Kyung Min Chung, Hyunhee Park, Jihyun Hong, Ji-Eun Gim, Hyosun Choi, Ye Won Lee, Jieun Choi, Ji Young Mun and Seong-Woon Yu. https://www.tandfonline.com/doi/abs/10.1080/15548627.2019.1695398?journalCode=kaup20

Ptpn6 inhibits caspase-8- and Ripk3/Mlkl-dependent inflammation – Mary Speir, Cameron J. Nowell, Alyce A. Chen, Joanne A. O’Donnell, Isaac S. Shamie, Paul R. Lakin, Akshay A. D’Cruz, Roman O. Braun, Jeff J. Babon, Rowena S. Lewis, Meghan Bliss-Moreau, Inbar Shlomovitz, Shu Wang, Louise H. Cengia, Anca I. Stoica, Razq Hakem, Michelle A. Kelliher, Lorraine A. O’Reilly, Heather Patsiouras, Kate E. Lawlor, Edie Weller, Nathan E. Lewis, Andrew W. Roberts, Motti Gerlic and Ben A. Croker. https://www.nature.com/articles/s41590-019-0550-7

XIAP Interaction with E2F1 and Sp1 via its BIR2 and BIR3 domains specific activated MMP2 to promote bladder cancer invasion – Jiheng Xu, Xiaohui Hua, Rui Yang, Honglei Jin, Jingxia Li, Junlan Zhu, Zhongxian Tian, Maowen Huang, Guosong Jiang, Haishan Huang and Chuanshu Huang. https://www.nature.com/articles/s41389-019-0181-8


Death receptors


Activation of invariant natural killer T cells stimulates adipose tissue remodeling via adipocyte death and birth in obesity – Jeu Park, Jin Young Huh, Jiyoung Oh, Jong In Kim, Sang Mun Han, KyungCheul Shin, Yong Geun Jeon, Sung Sik Choe, Jiyoung Park and Jae Bum Kim. http://genesdev.cshlp.org/content/33/23-24/1657.abstract?etoc

Small molecules that inhibit TNF signalling by stabilising an asymmetric form of the trimer – James O’Connell, John Porter, Boris Kroeplien, Tim Norman, Stephen Rapecki, Rachel Davis, David McMillan, Tracy Arakaki, Alex Burgin, David Fox III, Tom Ceska, Fabien Lecomte, Alison Maloney, Alex Vugler, Bruce Carrington, Benjamin P Cossins, Tim Bourne and Alastair Lawson. https://www.nature.com/articles/s41467-019-13718-w

Disulfide bond-disrupting agents activate the tumor necrosis family-related apoptosis-inducing ligand/death receptor 5 pathway – Mengxiong Wang, Mary E. Law, Bradley J. Davis, Elham Yaaghubi, Amanda F. Ghilardi, Renan B. Ferreira, Chi-Wu Chiang, Olga A. Guryanova, Daniel Kopinke, Coy D. Heldermon, Ronald K. Castellano and Brian K. Law. https://www.nature.com/articles/s41420-019-0228-9


Bcl-2 family proteins


Mcl-1 Interacts with Akt to Promote Lung Cancer Progression – Guo Chen, Dongkyoo Park, Andrew T. Magis, Madhusmita Behera, Suresh S. Ramalingam, Taofeek K. Owonikoko, Gabriel L. Sica, Keqiang Ye, Chao Zhang, Zhengjia Chen, Walter J. Curran and Xingming Deng. https://cancerres.aacrjournals.org/content/79/24/6126

Context-specific regulation of cell survival by a miRNA-controlled BIM rheostat – Verena Labi, Siying Peng, Filippos Klironomos, Mathias Munschauer, Nicolai Kastelic, Tirtha Chakraborty, Katia Schoeler, Emmanuel Derudder, Manuela Martella, Guido Mastrobuoni, Luis R. Hernandez-Miranda, Ines Lahmann, Christine Kocks, Carmen Birchmeier, Stefan Kempa, Leticia Quintanilla-Martinez de Fend, Markus Landthaler, Nikolaus Rajewsky and Klaus Rajewsky. http://genesdev.cshlp.org/content/33/23-24/1673.abstract?etoc

Exploring the potential of BH3 mimetic therapy in squamous cell carcinoma of the head and neck – Rachel J. Carter, Mateus Milani, Michael Butterworth, Ahoud Alotibi, Nicholas Harper, Govindaraju Yedida, Georgia Greaves, Aoula Al-Zebeeby, Andrea L. Jorgensen, Andrew G. Schache, Janet M. Risk, Richard J. Shaw, Terry M. Jones, Joseph J. Sacco, Adam Hurlstone, Gerald M. Cohen and Shankar Varadarajan. https://www.nature.com/articles/s41419-019-2150-8

Side-by-side comparison of BH3-mimetics identifies MCL-1 as a key therapeutic target in AML – Larissa Ewald, Jessica Dittmann, Meike Vogler and Simone Fulda. https://www.nature.com/articles/s41419-019-2156-2


Pyroptosis / Gasdermin D


Bacterial Endotoxin Activates the Coagulation Cascade through Gasdermin D-Dependent Phosphatidylserine Exposure – Xinyu Yang, Xiaoye Cheng, Yiting Tang, Xianhui Qiu, Yupeng Wang, Haixia Kang, Jianfeng Wu, Zhongtai Wang, Yukun Liu, Fangping Chen, Xianzhong Xiao, Nigel Mackman, Timothy R. Billiar, Jiahuai Han, Ben Lu. https://www.cell.com/immunity/fulltext/S1074-7613(19)30463-7

Pyroptosis is a critical inflammatory pathway in the placenta from early onset preeclampsia and in human trophoblasts exposed to hypoxia and endoplasmic reticulum stressors – Shi-Bin Cheng, Akitoshi Nakashima, Warren J. Huber, Sarah Davis, Sayani Banerjee, Zheping Huang, Shigeru Saito, Yoel Sadovsky and Surendra Sharma. https://www.nature.com/articles/s41419-019-2162-4


Ferroptosis


Radiotherapy and Immunotherapy Promote Tumoral Lipid Oxidation and Ferroptosis via Synergistic Repression of SLC7A11 – Xueting Lang, Michael D. Green, Weimin Wang, Jiali Yu, Jae Eun Choi, Long Jiang, Peng Liao, Jiajia Zhou, Qiang Zhang, Ania Dow, Anjali L. Saripalli, Ilona Kryczek, Shuang Wei, Wojciech Szeliga, Linda Vatan, Everett M. Stone, George Georgiou, Marcin Cieslik, Daniel R. Wahl, Meredith A. Morgan, Arul M. Chinnaiyan, Theodore S. Lawrence and Weiping Zou. https://cancerdiscovery.aacrjournals.org/content/9/12/1673

Prominin2 Drives Ferroptosis Resistance by Stimulating Iron Export – Caitlin W. Brown, John J. Amante, Peter Chhoy, Ameer L. Elaimy, Haibo Liu, Lihua Julie Zhu, Christina E. Baer, Scott J. Dixon, Arthur M. Mercurio. https://www.cell.com/developmental-cell/fulltext/S1534-5807(19)30816-0


Efferocytosis


Interpreting an apoptotic corpse as anti-inflammatory involves a chloride sensing pathway – Justin S. A. Perry, Sho Morioka, Christopher B. Medina, J. Iker Etchegaray, Brady Barron, Michael H. Raymond, Christopher D. Lucas, Suna Onengut-Gumuscu, Eric Delpire and Kodi S. Ravichandran. https://www.nature.com/articles/s41556-019-0431-1

Dectin-1 Binding to Annexins on Apoptotic Cells Induces Peripheral Immune Tolerance via NADPH Oxidase-2 – Kevin Bode, Fatmire Bujupi, Corinna Link, Tobias Hein, Stephanie Zimmermann, Diluka Peiris, Vincent Jaquet, Bernd Lepenies, Heiko Weyd, Peter H. Krammer. https://www.cell.com/cell-reports/fulltext/S2211-1247(19)31577-3

PLAG enhances macrophage mobility for efferocytosis of apoptotic neutrophils via membrane redistribution of P2Y2 – Guen Tae Kim, Kyu Woong Hahn, Ki‐Young Sohn, Sun Young Yoon, Jae Wha Kim. https://febs.onlinelibrary.wiley.com/doi/abs/10.1111/febs.15135

A role for phagocytosis in inducing cell death during thymocyte negative selection – Nadia S Kurd, Lydia K Lutes, Jaewon Yoon, Shiao Wei Chan, Ivan L Dzhagalov, Ashley R Hoover, Ellen A Robey. https://elifesciences.org/articles/48097


Miscellanous


A mitochondrial megachannel resides in monomeric F1FO ATP synthase – Nelli Mnatsakanyan, Marc C. Llaguno, Youshan Yang, Yangyang Yan, Joachim Weber, Fred J. Sigworth and Elizabeth A. Jonas. https://www.nature.com/articles/s41467-019-13766-2

Post-translational Modification of OTULIN Regulates Ubiquitin Dynamics and Cell Death – Todd Douglas, Maya Saleh. https://www.cell.com/cell-reports/fulltext/S2211-1247(19)31485-8


Reviews


Cannibalism in Breast Cancer: The Dangers of Overeating – Sue Haupt, Simon P. Keam, Ygal Haupt. https://www.cell.com/trends/cancer/fulltext/S2405-8033(19)30201-8

Current translational potential and underlying molecular mechanisms of necroptosis – Tamás Molnár, Anett Mázló, Vera Tslaf, Attila Gábor Szöllősi, Gabriella Emri and Gábor Koncz. https://www.nature.com/articles/s41419-019-2094-z

Ecdysone controlled cell and tissue deletion – Tianqi Xu, Xin Jiang, Donna Denton and Sharad Kumar. https://www.nature.com/articles/s41418-019-0456-9

The DNA-damage response and nuclear events as regulators of nonapoptotic forms of cell death – Evgeniia A. Prokhorova, Aleksandra Yu. Egorshina, Boris Zhivotovsky & Gelina S. Kopeina. https://www.nature.com/articles/s41388-019-0980-6


Comments / other


Prominin-2 Suppresses Ferroptosis Sensitivity – Alexia Belavgeni, Stefan R. Bornstein, Andreas Linkermann. https://www.cell.com/developmental-cell/fulltext/S1534-5807(19)30935-9

Iron expulsion by exosomes drives ferroptosis resistance – Paulina Strzyz. https://www.nature.com/articles/s41580-019-0195-2

Cell death and regeneration in Dresden—the 27th meeting of the European Cell Death Organization – Andreas Linkermann and Dagmar Kulms. https://www.nature.com/articles/s41419-019-2153-5

In conversation with Gerard Evan – Paraminder Dhillon, Gerard Evan. https://febs.onlinelibrary.wiley.com/doi/full/10.1111/febs.15121

ApoList – November 2019


Bcl-2 family proteins


Destabilization of NOXA mRNA as a common resistance mechanism to targeted therapies – Joan Montero, Cécile Gstalder, Daniel J. Kim, Dorota Sadowicz, Wayne Miles, Michael Manos, Justin R. Cidado, J. Paul Secrist, Adriana E. Tron, Keith Flaherty, F. Stephen Hodi, Charles H. Yoon, Anthony Letai, David E. Fisher and Rizwan Haq. https://www.nature.com/articles/s41467-019-12477-y

Targeting melanoma’s MCL1 bias unleashes the apoptotic potential of BRAF and ERK1/2 pathway inhibitors – Matthew J. Sale, Emma Minihane, Noel R. Monks, Rebecca Gilley, Frances M. Richards, Kevin P. Schifferli, Courtney L. Andersen, Emma J. Davies, Mario Aladren Vicente, Eiko Ozono, Aleksandra Markovets, Jonathan R. Dry, Lisa Drew, Vikki Flemington, Theresa Proia, Duncan I. Jodrell, Paul D. Smith and Simon J. Cook. https://www.nature.com/articles/s41467-019-12409-w

Bok regulates mitochondrial fusion and morphology – Jacqualyn J. Schulman, Laura M. Szczesniak, Eric N. Bunker, Heather A. Nelson, Michael W. Roe, Larry E. Wagner II, David I. Yule and Richard J. H. Wojcikiewicz. https://www.nature.com/articles/s41418-019-0327-4

A small molecule protects mitochondrial integrity by inhibiting mTOR activity – Ran Cao, Li Li, Zhengxin Ying, Zichen Cao, Yongfen Ma, Xiaoxu Mao, Jiaojiao Li, Xiangbing Qi, Zhiyuan Zhang and Xiaodong Wang. https://www.pnas.org/content/116/46/23332.abstract

Humanin induces conformational changes in the apoptosis regulator BAX and sequesters it into fibers, preventing mitochondrial outer-membrane permeabilization – Daniel L Morris, David W Kastner, Sabrina Johnson, Marie-Paule Strub, Yi He, Christopher K.E. Bleck, Duck-Yeon Lee and Nico Tjandra. http://www.jbc.org/content/early/2019/11/05/jbc.RA119.011297.abstract

Inhibition of Bcl-2 Synergistically Enhances the Antileukemic Activity of Midostaurin and Gilteritinib in Preclinical Models of FLT3-Mutated Acute Myeloid Leukemia – Jun Ma, Shoujing Zhao, Xinan Qiao, Tristan Knight, Holly Edwards, Lisa Polin, Juiwanna Kushner, Sijana H. Dzinic, Kathryn White, Guan Wang, Lijing Zhao, Hai Lin, Yue Wang, Jeffrey W. Taub and Yubin Ge. https://clincancerres.aacrjournals.org/content/25/22/6815


Death receptors


3D Cellular Architecture Modulates Tyrosine Kinase Activity, Thereby Switching CD95-Mediated Apoptosis to Survival – Gülce S. Gülcüler Balta, Cornelia Monzel, Susanne Kleber, Joel Beaudouin, Emre Balta, Thomas Kaindl, Si Chen, Liang Gao, Meinolf Thiemann, Christian R. Wirtz, Yvonne Samstag, Motomu Tanaka, Ana Martin-Villalba. https://www.cell.com/cell-reports/fulltext/S2211-1247(19)31368-3

TAK1 suppresses RIPK1-dependent cell death and is associated with disease progression in melanoma – Biswajit Podder, Cristiano Guttà, Jan Rožanc, Elke Gerlach, Maria Feoktistova, Diana Panayotova-Dimitrova, Leonidas G. Alexopoulos, Martin Leverkus and Markus Rehm. https://www.nature.com/articles/s41418-019-0315-8

TRAIL-induced variation of cell signaling states provides nonheritable resistance to apoptosis – Baskar R, Fienberg HG, Khair Z, Favaro P, Kimmey S, Green DR, Nolan GP, Plevritis S, Bendall SC. http://www.life-science-alliance.org:/cgi/content/abstract/2/6/e201900554

Targeted enhancement of the therapeutic window of L19-TNF by transient and selective inhibition of RIPK1-signaling cascade – Sheila Dakhel, Tiziano Ongaro, Baptiste Gouyou, Mattia Matasci, Alessandra Villa, Dario Neri  and  Samuele Cazzamalli. http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=view&path[]=27320&path[]=88609


Caspases and IAPs


Activity of caspase-8 determines plasticity between cell death pathways – Kim Newton, Katherine E. Wickliffe, Allie Maltzman, Debra L. Dugger, Rohit Reja, Yue Zhang, Merone Roose-Girma, Zora Modrusan, Meredith S. Sagolla, Joshua D. Webster and Vishva M. Dixit. https://www.nature.com/articles/s41586-019-1752-8

Caspase-8 is the molecular switch for apoptosis, necroptosis and pyroptosis – Melanie Fritsch, Saskia D. Günther, Robin Schwarzer, Marie-Christine Albert, Fabian Schorn, J. Paul Werthenbach, Lars M. Schiffmann, Neil Stair, Hannah Stocks, Jens M. Seeger, Mohamed Lamkanfi, Martin Krönke, Manolis Pasparakis and Hamid Kashkar. https://www.nature.com/articles/s41586-019-1770-6

Sustained Secretion of the Antimicrobial Peptide S100A7 Is Dependent on the Downregulation of Caspase-8 – Tanay Bhatt, Aishwarya Bhosale, Bhavya Bajantri, Mruthyunjaya Swamy Mathapathi, Abrar Rizvi, Giorgio Scita, Amitabha Majumdar, Colin Jamora. https://www.cell.com/cell-reports/fulltext/S2211-1247(19)31412-3

Potent and selective caspase-2 inhibitor prevents MDM-2 cleavage in reversine-treated colon cancer cells – Marcin Poreba, Wioletta Rut, Katarzyna Groborz, Scott J. Snipas, Guy S. Salvesen and Marcin Drag. https://www.nature.com/articles/s41418-019-0329-2

The HtrA3 protease promotes drug‐induced death of lung cancer cells by cleavage of the X‐linked inhibitor of apoptosis protein (XIAP) – Tomasz Wenta, Michal Rychlowski, Ewelina Jurewicz, Miroslaw Jarzab, Dorota Zurawa‐Janicka, Anna Filipek, Barbara Lipinska. https://febs.onlinelibrary.wiley.com/doi/abs/10.1111/febs.14977


Necroptosis and RIPK


RIP1 kinase mediates angiogenesis by modulating macrophages in experimental neovascularization – Takashi Ueta, Kenji Ishihara, Shoji Notomi, Jong-Jer Lee, Daniel E. Maidana, Nikolaos E. Efstathiou, Yusuke Murakami, Eiichi Hasegawa, Kunihiro Azuma, Tetsuya Toyono, Eleftherios I. Paschalis, Makoto Aihara, Joan W. Miller and Demetrios G. Vavvas. https://www.pnas.org/content/116/47/23705.abstract


Efferocytosis, entosis etc


Chemotherapy-induced senescent cancer cells engulf other cells to enhance their survival – Crystal A. Tonnessen-Murray, Wesley D. Frey, Sonia G. Rao, Ashkan Shahbandi, Nathan A. Ungerleider, Joy O. Olayiwola, Lucas B. Murray, Benjamin T. Vinson, Douglas B. Chrisey, Christopher J. Lord and James G. Jackson. http://jcb.rupress.org/content/218/11/3827?etoc

Plexin B2 Is a Regulator of Monocyte Apoptotic Cell Disassembly – Georgia K. Atkin-Smith, Mark A. Miles, Rochelle Tixeira, Fung T. Lay, Mubing Duan, Christine J. Hawkins, Thanh Kha Phan, Stephanie Paone, Suresh Mathivanan, Mark D. Hulett, Weisan Chen, Ivan K.H. Poon. https://www.cell.com/cell-reports/fulltext/S2211-1247(19)31314-2


Miscellanous


Defining the role of cytoskeletal components in the formation of apoptopodia and apoptotic bodies during apoptosis – Sarah Caruso, Georgia K. Atkin-Smith, Amy A. Baxter, Rochelle Tixeira, Lanzhou Jiang, Dilara C. Ozkocak, Jascinta P. Santavanond, Mark D. Hulett, Peter Lock, Thanh Kha Phan and Ivan K. H. Poon. https://link.springer.com/article/10.1007/s10495-019-01565-5

Lipid order and charge protect killer T cells from accidental death – Jesse A. Rudd-Schmidt, Adrian W. Hodel, Tahereh Noori, Jamie A. Lopez, Hyun-Jung Cho, Sandra Verschoor, Annette Ciccone, Joseph A. Trapani, Bart W. Hoogenboom and Ilia Voskoboinik. https://www.nature.com/articles/s41467-019-13385-x


Reviews


MCL1 as a Therapeutic Target in Parkinson’s Disease? – Edward J. Robinson, Sebastian Aguiar, Marten P. Smidt, Lars P. van der Heide. https://www.cell.com/trends/molecular-medicine/fulltext/S1471-4914(19)30232-1

Gasdermins and their role in immunity and inflammation – Pontus Orning, Egil Lien and Katherine A. Fitzgerald. http://jem.rupress.org/content/216/11/2453?etoc


Comments


Lipid metabolism offers anticancer treatment by regulating ferroptosis – Michele Carbone and Gerry Melino. https://www.nature.com/articles/s41418-019-0418-2

A powerful cell-protection system prevents cell death by ferroptosis – Brent R. Stockwell. https://www.nature.com/articles/d41586-019-03145-8

ApoList – October 2019


Bcl-2 family proteins


Mitochondrial Reprogramming Underlies Resistance to BCL-2 Inhibition in Lymphoid Malignancies – Romain Guièze, Vivian M. Liu, Daniel Rosebrock, Alexis A. Jourdain, María Hernández-Sánchez, Aina Martinez Zurita, Jing Sun, Elisa Ten Hacken, Kaitlyn Baranowski, Philip A. Thompson, Jin-Mi Heo, Zachary Cartun, Ozan Aygün, J. Bryan Iorgulescu, Wandi Zhang, Giulia Notarangelo, Dimitri Livitz, Shuqiang Li, Matthew S. Davids, Anat Biran, Stacey M. Fernandes, Jennifer R. Brown, Ana Lako, Zoe B. Ciantra, Matthew A. Lawlor, Derin B. Keskin, Namrata D. Udeshi, William G. Wierda, Kenneth J. Livak, Anthony G. Letai, Donna Neuberg, J. Wade Harper, Steven A. Carr, Federica Piccioni, Christopher J. Ott, Ignaty Leshchiner, Cory M. Johannessen, John Doench, Vamsi K. Mootha, Gad Getz, Catherine J. Wu. https://www.cell.com/cancer-cell/fulltext/S1535-6108(19)30373-3

Preferential targeting of MCL-1 by a hydrocarbon-stapled BIM BH3 peptide – Abbas Hadji, Greta K. Schmitt, Mathew R. Schnorenberg, Lauren Roach, Connie M. Hickey, Logan B. Leak, Matthew V. Tirrell and James L. LaBelle. http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=view&path[]=27262&path[]=87960

The transcription factor ETS1 promotes apoptosis resistance of senescent cholangiocytes by epigenetically up-regulating the apoptosis suppressor BCL2L1 – Steven P. O’Hara, Patrick L. Splinter, Christy E. Trussoni, E. Guicciardi, Noah P. Splinter, Mohammed S. Al Suraih, Navine Nasser-Ghodsi, Deborah Stollenwerk, Gregory J. Gores and Nicholas F. LaRusso. http://www.jbc.org/content/early/2019/10/28/jbc.RA119.010176.abstract


Death receptors, caspases and IAPs


Caspase-7 uses RNA to enhance proteolysis of poly(ADP-ribose) polymerase 1 and other RNA-binding proteins – Alexandre Desroches and Jean-Bernard Denault. https://www.pnas.org/content/116/43/21521.abstract?etoc

Interplay between Caspase 9 and X-linked Inhibitor of Apoptosis Protein (XIAP) in the oocyte elimination during fetal mouse development – Xueqing Liu, Veronica Castle and Teruko Taketo. https://www.nature.com/articles/s41419-019-2019-x

Dual Antagonist of cIAP/XIAP ASTX660 Sensitizes HPV− and HPV+ Head and Neck Cancers to TNFα, TRAIL, and Radiation Therapy – Roy Xiao, Yi An, Wenda Ye, Adeeb Derakhshan, Hui Cheng, Xinping Yang, Clint Allen, Zhong Chen, Nicole C. Schmitt and Carter Van Waes. https://clincancerres.aacrjournals.org/content/25/21/6463

Tumor Necrosis Factor Related Apoptosis Inducing Ligand (TRAIL) Regulates Deubiquitinase USP5 In Tumor Cells – Harish Potu, Malathi Kandarpa, Luke F. Peterson, Nicholas J. Donato and Moshe Talpaz. http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=view&path[]=27196&path[]=87593


Necroptosis


Pannexin‐1 limits the production of proinflammatory cytokines during necroptosis – Tiphaine Douanne, Gwennan André‐Grégoire, Kilian Trillet, An Thys, Antonin Papin, Magalie Feyeux, Philippe Hulin, David Chiron, Julie Gavard, Nicolas Bidère. https://www.embopress.org/doi/abs/10.15252/embr.201947840


Ferroptosis


FSP1 is a glutathione-independent ferroptosis suppressor – Sebastian Doll, Florencio Porto Freitas, Ron Shah, Maceler Aldrovandi, Milene Costa da Silva, Irina Ingold, Andrea Goya Grocin, Thamara Nishida Xavier da Silva, Elena Panzilius, Christina Scheel, André Mourão, Katalin Buday, Mami Sato, Jonas Wanninger, Thibaut Vignane, Vaishnavi Mohana, Markus Rehberg, Andrew Flatley, Aloys Schepers, Andreas Kurz, Daniel White, Markus Sauer, Michael Sattler, Edward William Tate, Werner Schmitz, Almut Schulze, Valerie O’Donnel, Bettina Proneth, Grzegorz M. Popowicz, Derek Pratt, José Pedro Friedmann Angeli and Marcus Conrad. https://www.nature.com/articles/s41586-019-1707-0

The CoQ oxidoreductase FSP1 acts parallel to GPX4 to inhibit ferroptosis – Kirill Bersuker, Joseph Hendricks, Zhipeng Li, Leslie Magtanong, Breanna Ford, Peter H. Tang, Melissa A. Roberts, Bingqi Tong, Thomas J. Maimone, Roberto Zoncu, Michael C. Bassik, Daniel K. Nomura, Scott J. Dixon and James A. Olzmann. https://www.nature.com/articles/s41586-019-1705-2

Exquisite sensitivity of adrenocortical carcinomas to induction of ferroptosis – Alexia Belavgeni, Stefan R. Bornstein, Anne von Mässenhausen, Wulf Tonnus, Julian Stumpf, Claudia Meyer, Evelyn Othmar, Markus Latk, Waldemar Kanczkowski, Matthias Kroiss, Constanze Hantel, Christian Hugo, Martin Fassnacht, Christian G. Ziegler, Andrew V. Schally, Nils P. Krone and Andreas Linkermann. https://www.pnas.org/content/116/44/22269.abstract?etoc

Ischemia-induced ACSL4 activation contributes to ferroptosis-mediated tissue injury in intestinal ischemia/reperfusion – Yang Li, Dongcheng Feng, Zhanyu Wang, Yan Zhao, Ruimin Sun, Donghai Tian, Deshun Liu, Feng Zhang, Shili Ning, Jihong Yao and Xiaofeng Tian. https://www.nature.com/articles/s41418-019-0299-4

Stearoyl-CoA Desaturase 1 Protects Ovarian Cancer Cells from Ferroptotic Cell Death – Lia Tesfay, Bibbin T. Paul, Anna Konstorum, Zhiyong Deng, Anderson O. Cox, Jingyun Lee, Cristina M. Furdui, Poornima Hegde, Frank M. Torti and Suzy V. Torti. https://cancerres.aacrjournals.org/content/79/20/5355

The oncometabolite 2-hydroxyglutarate produced by mutant IDH1 sensitizes cells to ferroptosis – Tian-Xiang Wang, Jun-Yun Liang, Cheng Zhang, Yue Xiong, Kun-Liang Guan and Hai-Xin Yuan. https://www.nature.com/articles/s41419-019-1984-4


Efferocytosis


Resolution metabolomes activated by hypoxic environment – Paul C. Norris, Stephania Libreros and Charles N. Serhan. https://advances.sciencemag.org/content/5/10/eaax4895

Phosphatidylserine on viable sperm and phagocytic machinery in oocytes regulate mammalian fertilization – Claudia M. Rival, Wenhao Xu, Laura S. Shankman, Sho Morioka, Sanja Arandjelovic, Chang Sup Lee, Karen M. Wheeler, Ryan P. Smith, Lisa B. Haney, Brant E. Isakson, Scott Purcell, Jeffrey J. Lysiak and Kodi S. Ravichandran. https://www.nature.com/articles/s41467-019-12406-z


Phagoptosis, entosis etc


Gulp1 controls Eph/ephrin trogocytosis and is important for cell rearrangements during development – Jingyi Gong, Thomas N. Gaitanos, Olivia Luu, Yunyun Huang, Louise Gaitanos, Jana Lindner, Rudolf Winklbauer and Rüdiger Klein. http://jcb.rupress.org/content/218/10/3455?etoc

Chemotherapy-induced senescent cancer cells engulf other cells to enhance their survival – Crystal A. Tonnessen-Murray, Wesley D. Frey, Sonia G. Rao, Ashkan Shahbandi, Nathan A. Ungerleider, Joy O. Olayiwola, Lucas B. Murray, Benjamin T. Vinson, Douglas B. Chrisey, Christopher J. Lord, James G. Jackson. http://jcb.rupress.org/content/early/2019/09/16/jcb.201904051


Natural killers


Extracellular NK histones promote immune cell anti-tumor activity by inducing cell clusters through binding to CD138 receptor – Beatriz Martín-Antonio, G. Suñe, A. Najjar, L. Perez-Amill, A. Antoñana-Vildosola, M. Castella, S. León, M. Velasco-de Andrés, F. Lozano, E. Lozano, C. Bueno, J. M. Estanyol, C. Muñoz-Pinedo, S. N. Robinson and A. Urbano-Ispizua. https://jitc.biomedcentral.com/articles/10.1186/s40425-019-0739-1

The Mechanism of Anti–PD-L1 Antibody Efficacy against PD-L1–Negative Tumors Identifies NK Cells Expressing PD-L1 as a Cytolytic Effector – Wenjuan Dong, Xiaojin Wu, Shoubao Ma, Yufeng Wang, Ansel P. Nalin, Zheng Zhu, Jianying Zhang, Don M. Benson, Kai He, Michael A. Caligiuri and Jianhua Yu. https://cancerdiscovery.aacrjournals.org/content/9/10/1422


Miscellanous


Serine-47 phosphorylation of cytochrome c in the mammalian brain regulates cytochrome c oxidase and caspase-3 activity – Hasini A. Kalpage, Asmita Vaishnav, Jenney Liu, Ashwathy Varughese, Junmei Wan, Alice A. Turner, Qinqin Ji, Matthew P. Zurek, Alexandr A. Kapralov, Valerian E. Kagan, Joseph S. Brunzelle, Maurice-Andre Recanati, Lawrence I. Grossman, Thomas H. Sanderson, Icksoo Lee, Arthur R. Salomon, Brian F. P. Edwards and Maik Hüttemann. https://www.fasebj.org/doi/abs/10.1096/fj.201901120R

Residual apoptotic activity of a tumorigenic p53 mutant improves cancer therapy responses – Oleg Timofeev, Boris Klimovich, Jean Schneikert, Michael Wanzel, Evangelos Pavlakis, Julia Noll, Samet Mutlu, Sabrina Elmshäuser, Andrea Nist, Marco Mernberger, Boris Lamp, Ulrich Wenig, Alexander Brobeil, Stefan Gattenlöhner, Kernt Köhler, Thorsten Stiewe. https://www.embopress.org/doi/full/10.15252/embj.2019102096

Mitochondrial NIX Promotes Tumor Survival in the Hypoxic Niche of Glioblastoma – Jinkyu Jung, Ying Zhang, Orieta Celiku, Wei Zhang, Hua Song, Brian J. Williams, Amber J. Giles, Jeremy N. Rich, Roger Abounader, Mark R. Gilbert and Deric M. Park. https://cancerres.aacrjournals.org/content/79/20/5218

Cell Competition Is Driven by Autophagy – Rina Nagata, Mai Nakamura, Yuya Sanaki, Tatsushi Igaki. https://www.cell.com/developmental-cell/fulltext/S1534-5807(19)30701-4


Reviews


The Diversification of Cell Death and Immunity: Memento Mori – Arnaud J. Legrand, Maria Konstantinou, Emily F. Goode, Pascal Meier. https://www.cell.com/molecular-cell/fulltext/S1097-2765(19)30691-4

Perspective: The Incomplete Puzzle of the BCL2 Proteins – Hector Flores-Romero and Ana J. García-Sáez. https://www.mdpi.com/2073-4409/8/10/1176


Comments


Senescent cells feed on their neighbours – Michael Overholtzer. https://www.nature.com/articles/d41586-019-03271-3

A powerful cell-protection system prevents cell death by ferroptosis – Brent R. Stockwell. https://www.nature.com/articles/d41586-019-03145-8

p53 defies convention again: a p53 mutant that has lost tumor suppression but still can kill – James J Manfredi. https://www.embopress.org/doi/abs/10.15252/embj.2019103322

Stearoyl CoA Desaturase Regulates Ferroptosis in Ovarian Cancer Offering New Therapeutic Perspectives – Michele Carbone and Gerry Melino. https://cancerres.aacrjournals.org/content/79/20/5149

Cell Competition Triggers Suicide by Autophagy – Caroline Dillard, Tor Erik Rusten. https://www.cell.com/developmental-cell/fulltext/S1534-5807(19)30770-1

Eph receptors and ephrins engage in cellular cannibalism – Elena B. Pasquale. http://jcb.rupress.org/content/218/10/3168?etoc

Apoptotic Caspases: A Double-Edged Sword in Radiation-Induced Immunogenicity – Mara De Martino, Claire Vanpouille-Box. https://www.cell.com/trends/cell-biology/fulltext/S0962-8924(19)30159-X

ApoList – September 2019


Death receptors


NK cells switch from granzyme B to death receptor–mediated cytotoxicity during serial killing – Isabel Prager, Clarissa Liesche, Hanna van Ooijen, Doris Urlaub, Quentin Verron, Niklas Sandström, Frank Fasbender,  Maren Claus, Roland Eils, Joël Beaudouin, Björn Önfelt, Carsten Watzl. http://jem.rupress.org/content/216/9/2113?etoc

TNFR2 induced priming of the inflammasome leads to a RIPK1-dependent cell death in the absence of XIAP – Janin Knop, Lisanne M. Spilgies, Stefanie Rufli, Ramona Reinhart, Lazaros Vasilikos, Monica Yabal, Erika Crowley, Philipp J. Jost, Rebecca A. Marsh, Harald Wajant, Mark D. Robinson, Thomas Kaufmann and W. Wei-Lynn Wong. https://www.nature.com/articles/s41419-019-1938-x

A20 protects cells from TNF-induced apoptosis through linear ubiquitin-dependent and -independent mechanisms – Dario Priem, Michael Devos, Sarah Druwé, Arne Martens, Karolina Slowicka, Adrian T. Ting, Manolis Pasparakis, Wim Declerq, Peter Vandenabeele, Geert van Loo and Mathieu J. M. Bertrand. https://www.nature.com/articles/s41419-019-1937-y

The volatile anesthetic sevoflurane reduces neutrophil apoptosis via Fas death domain–Fas-associated death domain interaction – Sophia Koutsogiannaki, Lifei Hou, Hasan Babazada, Toshiaki Okuno, Nathan Blazon-Brown, Sulpicio G. Soriano, Takehiko Yokomizo and Koichi Yuki. https://www.fasebj.org/doi/abs/10.1096/fj.201901360R?ai=ts&ui=ly8&af=T

Heterogeneous responses to low level death receptor activation are explained by random molecular assembly of the Caspase-8 activation platform – Matveeva A, Fichtner M, McAllister K, McCann C, Sturrock M, Longley DB, Prehn JHM. https://www.ncbi.nlm.nih.gov/pubmed/31553717


Caspases


Cleavage of RIPK1 by caspase-8 is crucial for limiting apoptosis and necroptosis – Kim Newton, Katherine E. Wickliffe, Debra L. Dugger, Allie Maltzman, Merone Roose-Girma, Monika Dohse, László Kőműves, Joshua D. Webster and Vishva M. Dixit. https://www.nature.com/articles/s41586-019-1548-x

Caspase-10 inhibits ATP-citrate lyase-mediated metabolic and epigenetic reprogramming to suppress tumorigenesis – Rajni Kumari, Ruhi S. Deshmukh and Sanjeev Das. https://www.nature.com/articles/s41467-019-12194-6

Salvador–Warts–Hippo pathway regulates sensory organ development via caspase-dependent nonapoptotic signaling – Lan-Hsin Wang and Nicholas E. Baker. https://www.nature.com/articles/s41419-019-1924-3


Necroptosis


Viral MLKL Homologs Subvert Necroptotic Cell Death by Sequestering Cellular RIPK3 – Emma J. Petrie, Jarrod J. Sandow, Wil I.L. Lehmann, Lung-Yu Liang, Diane Coursier, Samuel N. Young, Wilhelmus J.A. Kersten, Cheree Fitzgibbon, André L. Samson, Annette V. Jacobsen, Kym N. Lowes, Amanda E. Au, Hélène Jousset Sabroux, Najoua Lalaoui, Andrew I. Webb, Guillaume Lessene, Gerard Manning, Isabelle S. Lucet, James M. Murphy. https://www.cell.com/cell-reports/fulltext/S2211-1247(19)31103-9

TAK1 regulates endothelial cell necroptosis and tumor metastasis – Lida Yang, Sayali Joseph, Tianliang Sun, Julia Hoffmann, Sophia Thevissen, Stefan Offermanns and Boris Strilic. https://www.nature.com/articles/s41418-018-0271-8

Cell cycle arrest in mitosis promotes interferon-induced necroptosis – Tanja Frank, Marcel Tuppi, Manuela Hugle, Volker Dötsch, Sjoerd J. L. van Wijk and Simone Fulda. https://www.nature.com/articles/s41418-019-0298-5

The bromodomain protein BRD4 positively regulates necroptosis via modulating MLKL expression – Yu Xiong, Linli Li, Liting Zhang, Yangyang Cui, Chengyong Wu, Hui Li, Kai Chen, Qiuyuan Yang, Rong Xiang, Yiguo Hu, Shile Huang, Yuquan Wei and Shengyong Yang. https://www.nature.com/articles/s41418-018-0262-9

Ubiquitination of RIPK1 suppresses programmed cell death by regulating RIPK1 kinase activation during embryogenesis – Xixi Zhang, Haiwei Zhang, Chengxian Xu, Xiaoming Li, Ming Li, Xiaoxia Wu, Wenjuan Pu, Bin Zhou, Haikun Wang, Dali Li, Qiurong Ding, Hao Ying, Hui Wang and Haibing Zhang. https://www.nature.com/articles/s41467-019-11839-w

K63-linked ubiquitination regulates RIPK1 kinase activity to prevent cell death during embryogenesis and inflammation – Yong Tang, Hailin Tu, Jie Zhang, Xueqiang Zhao, Yini Wang, Jun Qin and Xin Lin. https://www.nature.com/articles/s41467-019-12033-8


Bcl-2 family proteins


Mitochondrial translocation of cyclin C stimulates intrinsic apoptosis through Bax recruitment – Jan Jezek, Kai‐Ti Chang, Amogh M Joshi, Randy Strich. https://www.embopress.org/doi/10.15252/embr.201847425

Therapeutic inhibition of Mcl-1 blocks cell survival in estrogen receptor-positive breast cancers – Michelle M. Williams, David L. Elion, Bushra Rahman, Donna J. Hicks, Violeta Sanchez and Rebecca S. Cook. http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=view&path[]=27070&path[]=87031


Pyroptosis


A genome‐wide screen identifies IRF2 as a key regulator of caspase‐4 in human cells – Sacha Benaoudia, Amandine Martin, Marta Puig Gamez, Gabrielle Gay, Brice Lagrange, Maxence Cornut, Kyrylo Krasnykov, Jean‐Baptiste Claude, Cyril F Bourgeois, Sandrine Hughes, Benjamin Gillet, Omran Allatif, Antoine Corbin, Romeo Ricci, Thomas Henry. https://www.embopress.org/doi/10.15252/embr.201948235


Ferroptosis


The Hippo Pathway Effector TAZ Regulates Ferroptosis in Renal Cell Carcinoma – Wen-Hsuan Yang, Chien-Kuang Cornelia Ding, Tianai Sun, Gabrielle Rupprecht, Chao-Chieh Lin, David Hsu, Jen-Tsan Chi. https://www.cell.com/cell-reports/fulltext/S2211-1247(19)31023-X


Efferocytosis


Migratory Neural Crest Cells Phagocytose Dead Cells in the Developing Nervous System – Yunlu Zhu, Samantha C. Crowley, Andrew J. Latimer, Gwendolyn M. Lewis, Rebecca Nash, Sarah Kucenas. https://www.cell.com/cell/fulltext/S0092-8674(19)30889-X

Sensing of apoptotic cells through Axl causes lung basal cell proliferation in inflammatory diseases – Naoya Fujino, Oliver J. Brand, David J. Morgan, Toshifumi Fujimori, Aleksander M. Grabiec, Christopher P. Jagger, Rose A. Maciewicz, Mitsuhiro Yamada, Koji Itakura, Hisatoshi Sugiura, Masakazu Ichinose, Tracy Hussell. http://jem.rupress.org/content/216/9/2184?etoc


Miscellanous


Single-Cell and Population-Level Analyses Using Real-Time Kinetic Labeling Couples Proliferation and Cell Death Mechanisms – Jesse D. Gelles, Jarvier N. Mohammed, Luis C. Santos, Diana Legarda, Adrian T. Ting, Jerry E. Chipuk. https://www.cell.com/developmental-cell/fulltext/S1534-5807(19)30699-9

Off-target toxicity is a common mechanism of action of cancer drugs undergoing clinical trials [including caspase-3 activators] – Ann Lin , Christopher J. Giuliano, Ann Palladino, Kristen M. John, Connor Abramowicz, Monet Lou Yuan, Erin L. Sausville, Devon A. Lukow, Luwei Liu, Alexander R. Chait, Zachary C. Galluzzo, Clara Tucker, Jason M. Sheltzer. https://stm.sciencemag.org/content/11/509/eaaw8412

In the absence of apoptosis, myeloid cells arrest when deprived of growth factor, but remain viable by consuming extracellular glucose – Li Dong, Boris Reljic, Jen G. Cheung, Elizabeth S. Ng, Lisa M. Lindqvist, Andrew G. Elefanty, David L. Vaux and Hoanh Tran. https://www.nature.com/articles/s41418-019-0275-z

TNF Induces Pathogenic Programmed Macrophage Necrosis in Tuberculosis through a Mitochondrial-Lysosomal-Endoplasmic Reticulum Circuit – Francisco J. Roca, Laura J. Whitworth, Sarah Redmond, Ana A. Jones, Lalita Ramakrishnan. https://www.cell.com/cell/fulltext/S0092-8674(19)30892-X

Estrogen-Related Hormones Induce Apoptosis by Stabilizing Schlafen-12 Protein Turnover – Dianrong Li, Jie Chen, Youwei Ai, Yang Cao, Xiangbin Qi, Xiaodong Wang. https://www.cell.com/molecular-cell/fulltext/S1097-2765(19)30497-6


Reviews


Population Dynamics in Cell Death: Mechanisms of Propagation – Michelle Riegman, Michelle S. Bradbury, Michael Overholtzer. https://www.cell.com/trends/cancer/fulltext/S2405-8033(19)30147-5

Apoptotic cell death regulation in neurons – Emilie Hollville, Selena E. Romero, Mohanish Deshmukh. https://febs.onlinelibrary.wiley.com/doi/full/10.1111/febs.14970


Comments


The Neural Crest Pitches In to Remove Apoptotic Debris – Aglaja Kopf, Michael Sixt. https://www.cell.com/cell/fulltext/S0092-8674(19)30966-3

The Dark Side of Estrogen Stops Translation to Induce Apoptosis – Heather M. Lamb, J. Marie Hardwick. https://www.cell.com/molecular-cell/fulltext/S1097-2765(19)30661-6

ApoList – August 2019


Necroptosis and RIP kinases


RIPK3 Activation Leads to Cytokine Synthesis that Continues after Loss of Cell Membrane Integrity – Susana L. Orozco, Brian P. Daniels, Nader Yatim, Michelle N. Messmer, Giovanni Quarato, Haiyin Chen-Harris, Sean P. Cullen, Annelise G. Snyder, Pooja Ralli-Jain, Sharon Frase, Stephen W.G. Tait, Douglas R. Green, Matthew L. Albert, Andrew Oberst. https://www.cell.com/cell-reports/fulltext/S2211-1247(19)30981-7

The AMPK–Parkin axis negatively regulates necroptosis and tumorigenesis by inhibiting the necrosome – Seung Baek Lee, Jung Jin Kim, Sang-Ah Han, Yingfang Fan, Li-Sha Guo, Khaled Aziz, Somaira Nowsheen, Sung Sun Kim, Seon-Young Park, Qifeng Luo, Jin Ook Chung, Sung Il Choi, Asef Aziz, Ping Yin, Seo-Yun Tong, Fabienne C. Fiesel, Wolfdieter Springer, Jin-San Zhang and Zhenkun Lou. https://www.nature.com/articles/s41556-019-0356-8

TAM Kinases Promote Necroptosis by Regulating Oligomerization of MLKL – Ayaz Najafov, Adnan K. Mookhtiar, Hoang Son Luu, Alban Ordureau, Heling Pan, Palak P. Amin, Ying Li, Qingxian Lu, Junying Yuan. https://www.cell.com/molecular-cell/fulltext/S1097-2765(19)30394-6


Bcl-2 family proteins


BIK ubiquitination by the E3 ligase Cul5-ASB11 determines cell fate during cellular stress – Fei-Yun Chen, Min-Yu Huang, Yu-Min Lin, Chi-Huan Ho, Shu-Yu Lin, Hsin-Yi Chen, Mien-Chie Hung, Ruey-Hwa Chen. http://jcb.rupress.org/content/early/2019/08/05/jcb.201901156

The CUL5 ubiquitin ligase complex mediates resistance to CDK9 and MCL1 inhibitors in lung cancer cells – Shaheen Kabir, Justin Cidado, Courtney Andersen, Cortni Dick, Pei-Chun Lin, Therese Mitros, Hong Ma, Seung Hyun Baik, Matthew A Belmonte, Lisa Drew, Jacob E Corn. https://elifesciences.org/articles/44288

Prediction of venetoclax activity in precursor B-ALL by functional assessment of apoptosis signaling – Felix Seyfried, Salih Demir, Rebecca Louise Hörl, Felix Uli Stirnweiß, Jeremy RyanAnnika Scheffold, , Mariana Villalobos-Ortiz, Elena Boldrin, Julia Zinngrebe, Stefanie Enzenmüller, Silvia Jenni, Yi-Chien Tsai, Beat Bornhauser, Axel Fürstberger, Johann Michael Kraus, Hans Armin Kestler, Jean-Pierre Bourquin, Stephan Stilgenbauer, Anthony Letai, Klaus-Michael Debatin and Lüder Hinrich Meyer. https://www.nature.com/articles/s41419-019-1801-0

Noxa mitochondrial targeting domain induces necrosis via VDAC2 and mitochondrial catastrophe – Ji-Hye Han, Junghee Park, Seung-Hyun Myung, Sung Hang Lee, Hwa-Young Kim, Kyung Sook Kim, Young-Woo Seo and Tae-Hyoung Kim. https://www.nature.com/articles/s41419-019-1753-4

DHX33 Interacts with AP-2β To Regulate Bcl-2 Gene Expression and Promote Cancer Cell Survival – Jiuling Wang, Weimin Feng, Zhen Yuan, Jason D. Weber and Yandong Zhang. http://mcb.asm.org/content/39/17/e00017-19.abstract


Death receptors and IAPs


Characterization of TNF-induced cell death in Drosophila reveals caspase- and JNK-dependent necrosis and its role in tumor suppression – Mingli Li, Shiyao Sun, Jessica Priest, Xiaolin Bi and Yun Fan. https://www.nature.com/articles/s41419-019-1862-0

Hantavirus Inhibits TRAIL-Mediated Killing of Infected Cells by Downregulating Death Receptor 5 – Carles Solà-Riera, Shawon Gupta, Kimia T. Maleki, Patricia González-Rodriguez, Dalel Saidi, Christine L. Zimmer, Sindhu Vangeti, Laura Rivino, Yee-Sin Leo, David Chien Lye, Paul A. MacAry, Clas Ahlm, Anna Smed-Sörensen, Bertrand Joseph, Niklas K. Björkström, Hans-Gustaf Ljunggren, Jonas Klingström. https://www.cell.com/cell-reports/fulltext/S2211-1247(19)30970-2

The anticonvulsive Phenhydan® suppresses extrinsic cell death – Caroline Moerke, Isabel Jaco, Christin Dewitz, Tammo Müller, Annette V. Jacobsen, Jérémie Gautheron, Jürgen Fritsch, Jessica Schmitz, Jan Hinrich Bräsen, Claudia Günther, James M. Murphy, Ulrich Kunzendorf, Pascal Meier and Stefan Krautwald. https://www.nature.com/articles/s41418-018-0232-2

SMAC mimetics promote NIK-dependent inhibition of CD4+ TH17 cell differentiation – John Rizk , Joseph Kaplinsky, Rasmus Agerholm, Darshana Kadekar, Fredrik Ivars, William W. Agace, W. Wei-Lynn Wong, Matthew J. Szucs, Samuel A. Myers, Steven A. Carr, Ari Waisman, Vasileios Bekiaris. https://stke.sciencemag.org/content/12/596/eaaw3469


Caspases


Caspase-8 modulates physiological and pathological angiogenesis during retina development – Nathalie Tisch, Aida Freire-Valls, Rosario Yerbes, Isidora Paredes, Silvia La Porta, Xiaohong Wang,Rosa Martín-Pérez, Laura Castro, Wendy Wei-Lynn Wong, Leigh Coultas, Boris Strilic, Hermann-Josef Gröne, Thomas Hielscher, Carolin Mogler, Ralf Adams, Peter Heiduschka, Lena Claesson-Welsh,Massimiliano Mazzone, Abelardo López-Rivas, Thomas Schmidt, Hellmut G. Augustin and Carmen Ruiz de Almodovar. https://www.jci.org/articles/view/122767

Caspase-2 promotes AMPA receptor internalization and cognitive flexibility via mTORC2-AKT-GSK3β signaling – Zhi-Xiang Xu, Ji-Wei Tan, Haifei Xu, Cassandra J. Hill, Olga Ostrovskaya, Kirill A. Martemyanov and Baoji Xu. https://www.nature.com/articles/s41467-019-11575-1

The cleavage of gasdermin D by caspase-11 promotes tubular epithelial cell pyroptosis and urinary IL-18 excretion in acute kidney injury – Miao N, Yin F, Xie H, Wang Y, Xu Y, Shen Y, Xu D, Yin J, Wang B, Zhou Z, Cheng Q, Chen P, Xue H, Zhou L, Liu J, Wang X, Zhang W, Lu L. https://www.ncbi.nlm.nih.gov/pubmed/31405732

Caspase-mediated cleavage of IRE1 controls apoptotic cell commitment during endoplasmic reticulum stress – Anna Shemorry, Jonathan M Harnoss, Ofer Guttman, Scot A Marsters, László G Kőműves, David A Lawrence, Avi Ashkenazi. https://elifesciences.org/articles/47084


Efferocytosis / immunogenicity


Long-term tolerance of islet allografts in nonhuman primates induced by apoptotic donor leukocytes – Amar Singh, Sabarinathan Ramachandran, Melanie L. Graham, Saeed Daneshmandi, David Heller, Wilma Lucia Suarez-Pinzon, Appakalai N. Balamurugan, Jeffrey D. Ansite, Joshua J. Wilhelm, Amy Yang, Ying Zhang, Nagendra P. Palani, Juan E. Abrahante, Christopher Burlak, Stephen D. Miller, Xunrong Luo and Bernhard J. Hering. https://www.nature.com/articles/s41467-019-11338-y


Pyroptosis


ATP induces caspase-3/gasdermin E-mediated pyroptosis in NLRP3 pathway-blocked murine macrophages – Chen-Ying Zeng, Chen-Guang Li, Jun-Xiang Shu, Li-Hui Xu, Dong-Yun Ouyang, Feng-Yi Mai, Qiong-Zhen Zeng, Cheng-Cheng Zhang, Rui-Man Li and Xian-Hui He. https://link.springer.com/article/10.1007/s10495-019-01551-x


Miscellanous


NAD+ cleavage activity by animal and plant TIR domains in cell death pathways – Shane Horsefield, Hayden Burdett, Xiaoxiao Zhang, Mohammad K. Manik, Yun Shi, Jian Chen, Tiancong Qi, Jonathan Gilley, Jhih-Siang Lai, Maxwell X. Rank, Lachlan W. Casey, Weixi Gu, Daniel J. Ericsson, Gabriel Foley, Robert O. Hughes, Todd Bosanac, Mark von Itzstein, John P. Rathjen, Jeffrey D. Nanson, Mikael Boden, Ian B. Dry, Simon J. Williams, Brian J. Staskawicz, Michael P. Coleman, Thomas Ve, Peter N. Dodds, Bostjan Kobe. https://science.sciencemag.org/content/365/6455/793

TIR domains of plant immune receptors are NAD+-cleaving enzymes that promote cell death – Li Wan, Kow Essuman, Ryan G. Anderson, Yo Sasaki, Freddy Monteiro, Eui-Hwan Chung, Erin Osborne Nishimura, Aaron DiAntonio, Jeffrey Milbrandt, Jeffery L. Dangl, Marc T. Nishimura. https://science.sciencemag.org/content/365/6455/799

MYC paralog-dependent apoptotic priming orchestrates a spectrum of vulnerabilities in small cell lung cancer – Marcel A. Dammert, Johannes Brägelmann, Rachelle R. Olsen, Stefanie Böhm, Niloufar Monhasery, Christopher P. Whitney, Milind D. Chalishazar, Hannah L. Tumbrink, Matthew R. Guthrie, Sebastian Klein, Abbie S. Ireland, Jeremy Ryan, Anna Schmitt, Annika Marx, Luka Ozretić, Roberta Castiglione, Carina Lorenz, Ron D. Jachimowicz, Elmar Wolf, Roman K. Thomas, John T. Poirier, Reinhard Büttner, Triparna Sen, Lauren A. Byers, H. Christian Reinhardt, Anthony Letai, Trudy G. Oliver and Martin L. Sos. https://www.nature.com/articles/s41467-019-11371-x

Meiotic viral attenuation through an ancestral apoptotic pathway [yeast] – Jie Gao, Sabrina Chau, Fuad Chowdhury, Tina Zhou, Saif Hossain, G. Angus McQuibban and Marc D. Meneghini. https://www.pnas.org/content/116/33/16454.abstract?etoc

Inhibition of mitochondrial permeability transition by deletion of the ANT family and CypD – Jason Karch , Michael J. Bround, Hadi Khalil, Michelle A. Sargent, Nadina Latchman, Naohiro Terada, Pablo M. Peixoto, Jeffery D. Molkentin. https://advances.sciencemag.org/content/5/8/eaaw4597


Reviews / comments


Parkin inhibits necroptosis to prevent cancer – Kai Cao and Stephen W. G. Tait. https://www.nature.com/articles/s41556-019-0350-1

Parkin protects against necroptosis – Wei Wong. https://stke.sciencemag.org/content/12/595/eaaz1464

Parkin and AMPK team up against necroptosis – Paulina Strzyz. https://www.nature.com/articles/s41580-019-0165-8

Apoptosis regulation in the penumbra after ischemic stroke: expression of pro- and antiapoptotic proteins – Anatoly B. Uzdensky. https://link.springer.com/article/10.1007/s10495-019-01556-6

Still on time to register for ECDO conference 2019 in Dresden – https://www.ecdo.eu/ecdo2019/

ApoList – July 2019

 


Mitochondria and Bcl-2 family proteins


BCL-2 family protein BOK is a positive regulator of uridine metabolism in mammals – Rahul Srivastava, Zhipeng Cao, Christina Nedeva, Samara Naim, Daniel Bachmann, Tatiana Rabachini, Lahiru Gangoda, Sanjay Shahi, Jason Glab, Joseph Menassa, Laura Osellame, Tao Nelson, Yuniel Fernandez-Marrero, Fiona Brown, Andrew Wei, Francine Ke, Lorraine O’Reilly, Marcel Doerflinger, Cody Allison, Andrew Kueh, Rob Ramsay, Brian J. Smith, Suresh Mathivanan, Thomas Kaufmann and Hamsa Puthalakath. https://www.pnas.org/content/116/31/15469.abstract?etoc

Phenotypic selection with an intrabody library reveals an anti-apoptotic function of PKM2 requiring Mitofusin-1 – Liu, T., Kuwana, T., Zhang, H., Vander Heiden, M. G., Lerner, R. A. and Newmeyer, D. D. https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.2004413

The mitophagy receptor Bcl-2–like protein 13 stimulates adipogenesis by regulating mitochondrial oxidative phosphorylation and apoptosis in mice – Makoto Fujiwara, Li Tian, Phuong T. Le, Victoria E. DeMambro, Kathleen A. Becker, Clifford J. Rosen and Anyonya R. Guntur. http://www.jbc.org/content/early/2019/07/02/jbc.RA119.008630.abstract

JNK1 regulates RANKL-induced osteoclastogenesis via activation of a novel Bcl-2-Beclin1-autophagy pathway – Dianshan Ke, Lianmei Ji, Yu Wang, Xiaomin Fu, Jinyan Chen, Fan Wang, Dongbao Zhao, Ying Xue, Xuhua Lan and Jianming Hou. https://www.fasebj.org/doi/abs/10.1096/fj.201802597RR

Structural and functional analyses of hepatitis B virus X protein BH3-like domain and Bcl-xL interaction – Tian-Ying Zhang, Hong-Ying Chen, Jia-Li Cao, Hua-Long Xiong, Xiao-Bing Mo, Tian-Liang Li, Xiao-Zhen Kang, Jing-Hua Zhao, Bo Yin, Xiang Zhao, Cheng-Hao Huang, Quan Yuan, Ding Xue, Ning-Shao Xia and Y. Adam Yuan. https://www.nature.com/articles/s41467-019-11173-1

DRP-1 functions independently of mitochondrial structural perturbations to facilitate BH3 mimetic-mediated apoptosis – Mateus Milani, Alison J. Beckett, Aoula Al-Zebeeby, Xu Luo, Ian A. Prior, Gerald M. Cohen and Shankar Varadarajan. https://www.nature.com/articles/s41420-019-0199-x

Mcl-1 and Bcl-xL are essential for survival of the developing nervous system – Lauren C. Fogarty, Robert T. Flemmer, Brittany A. Geizer, Maria Licursi, Ahila Karunanithy, Joseph T. Opferman, Kensuke Hirasawa and Jacqueline L. Vanderluit. https://www.nature.com/articles/s41418-018-0225-1

Recipient BCL2 inhibition and NK cell ablation form part of a reduced intensity conditioning regime that improves allo-bone marrow transplantation outcomes – Yuhao Jiao, Joanne E. Davis, Jai Rautela, Emma M. Carrington, Mandy J. Ludford-Menting, Wilford Goh, Rebecca B. Delconte, Fernando Souza-Fonseca-Guimaraes, Rachel Koldej, Daniel Gray, David Huang, Ben T. Kile, Andrew M. Lew, David S. Ritchie and Nicholas D. Huntington. https://www.nature.com/articles/s41418-018-0228-y


Bcl-2 family inhibitors


BH3 profiling discriminates on-target small molecule BH3 mimetics from putative mimetics – Mariana Villalobos-Ortiz, Jeremy Ryan, Thelma N. Mashaka, Joseph T. Opferman and Anthony Letai. https://www.nature.com/articles/s41418-019-0391-9

Targeting Mitochondrial Structure Sensitizes Acute Myeloid Leukemia to Venetoclax Treatment – Xufeng Chen, Christina Glytsou, Hua Zhou, Sonali Narang, Denis E. Reyna, Andrea Lopez, Theodore Sakellaropoulos, Yixiao Gong, Andreas Kloetgen, Yoon Sing Yap, Eric Wang, Evripidis Gavathiotis, Aristotelis Tsirigos, Raoul Tibes and Iannis Aifantis. http://cancerdiscovery.aacrjournals.org/content/9/7/890

The TP53 Apoptotic Network Is a Primary Mediator of Resistance to BCL2 Inhibition in AML Cells – Tamilla Nechiporuk, Stephen E. Kurtz, Olga Nikolova, Tingting Liu, Courtney L. Jones, Angelo D’Alessandro, Rachel Culp-Hill, Amanda d’Almeida, Sunil K. Joshi, Mara Rosenberg, Cristina E. Tognon, Alexey V. Danilov, Brian J. Druker, Bill H. Chang, Shannon K McWeeney and Jeffrey W. Tyner. http://cancerdiscovery.aacrjournals.org/content/9/7/910

Cotargeting of BCL2 with Venetoclax and MCL1 with S63845 Is Synthetically Lethal In Vivo in Relapsed Mantle Cell Lymphoma – Dana Prukova, Ladislav Andera, Zuzana Nahacka, Jana Karolova, Michael Svaton, Magdalena Klanova, Ondrej Havranek, Jan Soukup, Karla Svobodova, Zuzana Zemanova, Diana Tuskova, Eva Pokorna, Karel Helman, Kristina Forsterova, Mariana Pacheco-Blanco, Petra Vockova, Adela Berkova, Eva Fronkova, Marek Trneny and Pavel Klener. http://clincancerres.aacrjournals.org/content/25/14/4455

Efficacy of venetoclax in relapsed chronic lymphocytic leukemia is influenced by disease and response variables – Andrew W. Roberts, Shuo Ma, Thomas J. Kipps, Steven E. Coutre, Matthew S.Davids, Barbara Eichhorst, Michael Hallek, John C. Byrd, KathryHumphrey, Lang Zhou, Brenda Chyla, Jacqueline Nielsen, Jalaja Potluri, Su Young Kim, Maria Verdugo, Stephan Stilgenbauer, William G. Wierda and John F. Seymour. http://bloodjournal.org/content/134/2/111.abstract?etoc

Tumor Lysis, Adverse Events, and Dose Adjustments in 297 Venetoclax-Treated CLL Patients in Routine Clinical Practice – Lindsey E. Roeker, Christopher P. Fox, Toby A. Eyre, Danielle M. Brander, John N. Allan, Stephen J. Schuster, Chadi Nabhan, Brian T. Hill, Nirav N. Shah, Frederick Lansigan, Maryam Yazdy, Bruce D. Cheson, Nicole Lamanna, Arun K. Singavi, Catherine C. Coombs, Paul M. Barr, Alan P. Skarbnik, Mazyar Shadman, Chaitra S. Ujjani, Hande H. Tuncer, Allison M. Winter, Joanna Rhodes, Colleen Dorsey, Hannah Morse, Charlene Kabel, John M. Pagel, Annalynn M. Williams, Ryan Jacobs, Andre Goy, Sivraj Muralikrishnan, Laurie Pearson, Andrea Sitlinger, Neil Bailey, Anna Schuh, Amy A. Kirkwood and Anthony R. Mato. http://clincancerres.aacrjournals.org/content/25/14/4264


Death receptors


TNFR1 membrane reorganization promotes distinct modes of TNFα signaling – Penny E. Morton , Camille Perrin, James Levitt, Daniel R. Matthews, Richard J. Marsh, Rosemary Pike, David McMillan, Alison Maloney, Simon Poland, Simon Ameer-Beg, Maddy Parsons. https://stke.sciencemag.org/content/12/592/eaaw2418

Dendritic cell NLRC4 regulates influenza A virus–specific CD4+ T cell responses through FasL expression – Emma E. Hornick, Jargalsaikhan Dagvadorj, Zeb R. Zacharias, Ann M. Miller, Ryan A. Langlois, Peter Chen, Kevin L. Legge, Gail A. Bishop, Fayyaz S. Sutterwala and Suzanne L. Cassel. https://www.jci.org/articles/view/124937

Fas signaling-mediated TH9 cell differentiation favors bowel inflammation and antitumor functions – Yingying Shen, Zhengbo Song, Xinliang Lu, Zeyu Ma, Chaojie Lu, Bei Zhang, Yinghu Chen, Meng Duan, Lionel Apetoh, Xu Li, Jufeng Guo, Ying Miao, Gensheng Zhang, Diya Yang, Zhijian Cai and Jianli Wang. https://www.nature.com/articles/s41467-019-10889-4

Crystal structure and activation mechanism of DR3 death domain – Xueying Yin, Wenqian Li, Huan Ma, Weihong Zeng, Chao Peng, Yajuan Li, Muziying Liu, Quan Chen, Rongbin Zhou, Tengchuan Jin. https://febs.onlinelibrary.wiley.com/doi/10.1111/febs.14834

The combination of TPL2 knockdown and TNFα causes synthetic lethality via caspase-8 activation in human carcinoma cell lines – Oksana B. Serebrennikova, Maria D. Paraskevopoulou, Elia Aguado-Fraile, Vasiliki Taraslia, Wenying Ren, Geeta Thapa, Jatin Roper, Keyong Du, Carlo M. Croce and Philip N. Tsichlis. https://www.pnas.org/content/116/28/14039.abstract

Minimal dosing of leukocyte targeting TRAIL decreases triple-negative breast cancer metastasis following tumor resection – Nidhi Jyotsana, Zhenjiang Zhang, Lauren E. Himmel, Fang Yu and Michael R. King. https://advances.sciencemag.org/content/5/7/eaaw4197

Augmenting Immunotherapy Impact by Lowering Tumor TNF Cytotoxicity Threshold – David W. Vredevoogd, Thomas Kuilman, Maarten A. Ligtenberg, Julia Boshuizen, Kelly E. Stecker, Beaunelle de Bruijn, Oscar Krijgsman, Xinyao Huang, Juliana C.N. Kenski, Ruben Lacroix, Riccardo Mezzadra, Raquel Gomez-Eerland, Mete Yildiz, Ilknur Dagidir, Georgi Apriamashvili, Nordin Zandhuis, Vincent van der Noort, Nils L. Visser, Christian U. Blank, Maarten Altelaar, Ton N. Schumacher, Daniel S. Peeper. https://www.cell.com/cell/fulltext/S0092-8674(19)30677-4


Caspases


Specificity for latent C termini links the E3 ubiquitin ligase CHIP to caspases – Matthew Ravalin, Panagiotis Theofilas, Koli Basu, Kwadwo A. Opoku-Nsiah, Victoria A. Assimon, Daniel Medina-Cleghorn, Yi-Fan Chen, Markus F. Bohn, Michelle Arkin, Lea T. Grinberg, Charles S. Craik and Jason E. Gestwicki. https://www.nature.com/articles/s41589-019-0322-6

Cullin-4B E3 ubiquitin ligase mediates Apaf-1 ubiquitination to regulate caspase-9 activity – Eri Ohta, Masanori Itoh, Masashi Ueda, Yoko Hida, Miao-xing Wang, Miki Hayakawa-Ogura, Shimo Li, Emika Nishida, Kazunori Ohta, Tana, Saiful Islam, Kiyomi Nakagawa, Tomomi Sunayama, Huayue Chen, So Hirata, Masashi Endo, Yoya Ohno, Toshiyuki Nakagawa. https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0219782

Caspase-8 restricts antiviral CD8 T cell hyperaccumulation – Yanjun Feng, Lisa P. Daley-Bauer, Linda Roback, Hongyan Guo, Heather S. Koehler, Marc Potempa, Lewis L. Lanier and Edward S. Mocarski. https://www.pnas.org/content/116/30/15170.abstract?etoc

E1A oncogene induced sensitization to NK cell induced apoptosis requires PIDD and Caspase-2 – Jay R. Radke, John M. Routes and James L. Cook. https://www.nature.com/articles/s41420-019-0189-z


Necroptosis and/or RIP kinases


Intratumoral activation of the necroptotic pathway components RIPK1 and RIPK3 potentiates antitumor immunity – Annelise G. Snyder, Nicholas W. Hubbard, Michelle N. Messmer, Sigal B. Kofman, Cassidy E. Hagan, Susana L. Orozco, Kristy Chiang, Brian P. Daniels, David Baker and Andrew Oberst. https://immunology.sciencemag.org/content/4/36/eaaw2004.long

Central nervous system regeneration is driven by microglia necroptosis and repopulation – Amy F. Lloyd, Claire L. Davies, Rebecca K. Holloway, Yasmine Labrak, Graeme Ireland, Dario Carradori, Alessandra Dillenburg, Eva Borger, Daniel Soong, Jill C. Richardson, Tanja Kuhlmann, Anna Williams, Jeffrey W. Pollard, Anne des Rieux, Josef Priller and Veronique E. Miron. https://www.nature.com/articles/s41593-019-0418-z


Pyroptosis


Crystal Structures of the Full-Length Murine and Human Gasdermin D Reveal Mechanisms of Autoinhibition, Lipid Binding, and Oligomerization – Zhonghua Liu, Chuanping Wang, Jie Yang, Bowen Zhou, Rui Yang, Rajesh Ramachandran, Derek W. Abbott, Tsan Sam Xiao. https://www.cell.com/immunity/fulltext/S1074-7613(19)30197-9


Necrosis


Serum FHR1 binding to necrotic-type cells activates monocytic inflammasome and marks necrotic sites in vasculopathies – Sarah Irmscher, Silke R. Brix, Svante L. H. Zipfel, Luke D. Halder, Sibel Mutlutürk, Sonia Wulf, Evaldas Girdauskas, Hermann Reichenspurner, Rolf A. K. Stahl, Berit Jungnickel, Thorsten Wiech, Peter F. Zipfel and Christine Skerk. https://www.nature.com/articles/s41467-019-10766-0

Intercellular interaction dictates cancer cell ferroptosis via NF2–YAP signalling – Jiao Wu, Alexander M. Minikes, Minghui Gao, Huijie Bian, Yong Li, Brent R. Stockwell, Zhi-Nan Chen and Xuejun Jiang. https://www.nature.com/articles/s41586-019-1426-6

Clockophagy is a novel selective autophagy process favoring ferroptosis – Minghua Yang, Pan Chen, Jiao Liu, Shan Zhu, Guido Kroemer, Daniel J. Klionsky, Michael T. Lotze, Herbert J. Zeh, Rui Kang and Daolin Tang. https://advances.sciencemag.org/content/5/7/eaaw2238.full

Curcumin reduces renal damage associated with rhabdomyolysis by decreasing ferroptosis-mediated cell death – Melania Guerrero-Hue, Cristina García-Caballero, Alejandra Palomino-Antolín, Alfonso Rubio-Navarro, Cristina Vázquez-Carballo, Carmen Herencia, Diego Martín-Sanchez, Víctor Farré-Alins, Javier Egea, Pablo Cannata, Manuel Praga, Alberto Ortiz, Jesús Egido, Ana Belén Sanz and Juan Antonio Moreno. https://www.fasebj.org/doi/abs/10.1096/fj.201900077R?ai=s4&ui=ly8&af=T


Reviews


Inflammatory caspase regulation: maintaining balance between inflammation and cell death in health and disease – Beatriz E. Bolívar, Tiphanie P. Vogel, Lisa Bouchier‐Hayes. https://febs.onlinelibrary.wiley.com/doi/10.1111/febs.14926

Mitochondria and Inflammation: Cell Death Heats Up – Esmee Vringer and Stephen W. G. Tait. https://www.frontiersin.org/articles/10.3389/fcell.2019.00100/full

Cell death–mediated cytokine release and its therapeutic implications – David E. Place and Thirumala-Devi Kanneganti. http://jem.rupress.org/content/216/7/1474?etoc


Comments


Keeping the Death Protein in Check – Longfei Wang, Hao Wu. https://www.cell.com/immunity/fulltext/S1074-7613(19)30281-X

Mitochondrial Homeostasis in AML and Gasping for Response in Resistance to BCL2 Blockade – Michael R. Savona and Jeffrey C. Rathmell. http://cancerdiscovery.aacrjournals.org/content/9/7/831

A Physiological Function for Ferroptosis in Tumor Suppression by the Immune System – Brent R. Stockwell, Xuejun Jiang. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(19)30315-8

ApoList – June 2019

 


Bcl-2 family proteins


A non‐death function of the mitochondrial apoptosis apparatus in immunity – Dominik Brokatzky, Benedikt Dörflinger, Aladin Haimovici, Arnim Weber, Susanne Kirschnek, Juliane Vier,Arlena Metz, Julia Henschel, Tobias Steinfeldt, Ian E Gentle, Georg Häcker. https://www.embopress.org/doi/10.15252/embj.2018100907

Structures of BCL-2 in complex with venetoclax reveal the molecular basis of resistance mutations – Richard W. Birkinshaw, Jia-nan Gong, Cindy S. Luo, Daisy Lio, Christine A. White, Mary Ann Anderson, Piers Blombery, Guillaume Lessene, Ian J. Majewski, Rachel Thijssen, Andrew W. Roberts, David C. S. Huang, Peter M. Colman and Peter E. Czabotar. https://www.nature.com/articles/s41467-019-10363-1

α7 nicotinic acetylcholine receptor upregulation by anti-apoptotic Bcl-2 proteins – Brent Dawe, Hong Yu, Shenyan Gu, Alissa N. Blackler, Jose A. Matta, Edward R. Siuda, Elizabeth B. Rex and David S. Bredt. https://www.nature.com/articles/s41467-019-10723-x

Impact of elevated anti-apoptotic MCL-1 and BCL-2 on the development and treatment of MLL-AF9 AML in mice – Natasha S. Anstee, Rebecca A. Bilardi, Ashley P. Ng, Zhen Xu, Mikara Robati, Cassandra J. Vandenberg and Suzanne Cory. https://www.nature.com/articles/s41418-018-0209-1

Alcohol exposure alters pre-mRNA splicing of antiapoptotic Mcl-1L isoform and induces apoptosis in neural progenitors and immature neurons – Martina Donadoni, Stephanie Cicalese, Dipak K. Sarkar, Sulie L. Chang and Ilker Kudret Sariyer. https://www.nature.com/articles/s41419-019-1673-3

Resistance to anti-microtubule drug-induced cell death is determined by regulation of BimEL expression – Weimei Ruan, Gireedhar Venkatachalam, Radoslaw Mikolaj Sobota, Liyan Chen, Loo Chien Wang, Alena Jacobson, Kathirvel Paramasivam and Uttam Surana. https://www.nature.com/articles/s41388-019-0727-4

MiR-35 buffers apoptosis thresholds in the C. elegans germline by antagonizing both MAPK and core apoptosis pathways – Anh T. Tran, Eric M. Chapman, Mathieu N. Flamand, Bin Yu, Samuel J. Krempel, Thomas F. Duchaine, Matthew Eroglu and W. Brent Derry. https://www.nature.com/articles/s41418-019-0325-6

XPO1 inhibitor KPT-330 synergizes with Bcl-xL inhibitor to induce cancer cell apoptosis by perturbing rRNA processing and Mcl-1 protein synthesis – Zhi-Chuan Zhu, Ji-Wei Liu, Can Yang, Miao Zhao and Zhi-Qi Xiong. https://www.nature.com/articles/s41419-019-1627-9


Death receptors


DR4-Ser424 O-GlcNAcylation Promotes Sensitization of TRAIL-Tolerant Persisters and TRAIL-Resistant Cancer Cells to Death – Hyeonjeong Lee, Yumin Oh, Young-Jun Jeon, Song-Yi Lee, Hyunjoo Kim, Ho-June Lee and Yong-Keun Jung. http://cancerres.aacrjournals.org/content/79/11/2839

c-FLIP and CD95 signaling are essential for survival of renal cell carcinoma – Tobias Luebke, Lisa Schwarz, Yan Yan Beer, Sabrina Schumann, Maria Misterek, Frida Ewald Sander, Carlos Plaza-Sirvent and Ingo Schmitz. https://www.nature.com/articles/s41419-019-1609-y


Caspases


Molecular basis of dimerization of initiator caspase was revealed by crystal structure of caspase-8 pro-domain – Hyun Ho Par. https://www.nature.com/articles/s41418-018-0200-x

Caspase-8 promotes c-Rel–dependent inflammatory cytokine expression and resistance against Toxoplasma gondii – Alexandra A. DeLaney, Corbett T. Berry, David A. Christian, Andrew Hart, Elisabet Bjanes, Meghan A. Wynosky-Dolfi, Xinyuan Li, Bart Tummers, Irina A. Udalova, Youhai H. Chen, Uri Hershberg, Bruce D. Freedman, Christopher A. Hunter and Igor E. Brodsky. https://www.pnas.org/content/116/24/11926.abstract?etoc

Gasdermin-D and Caspase-7 are the key Caspase-1/8 substrates downstream of the NAIP5/NLRC4 inflammasome required for restriction of Legionella pneumophila – Augusto V. Gonçalves, Shally R. Margolis , Gustavo F. S. Quirino, Danielle P. A. Mascarenhas, Isabella Rauch, Randilea D. Nichols, Eduard Ansaldo, May F. Fontana, Russell E. Vance and Dario S. Zamboni. https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1007886


Necroptosis


Necroptosis mediators RIPK3 and MLKL suppress intracellular Listeria replication independently of host cell killing – Kazuhito Sai, Cameron Parsons, John S. House, Sophia Kathariou and Jun Ninomiya-Tsuji. http://jcb.rupress.org/content/218/6/1994

Discovery of potent necroptosis inhibitors targeting RIPK1 kinase activity for the treatment of inflammatory disorder and cancer metastasis – Jue Hou, Jie Ju, Zili Zhang, Cong Zhao, Zhanhui Li, Jiyue Zheng, Tian Sheng, Hongjian Zhang, Linkun Hu, Xiaoliang Yu, Wei Zhang, Yangxin Li, Meng Wu, Haikuo Ma, Xiaohu Zhang and Sudan He. https://www.nature.com/articles/s41419-019-1735-6

FKBP12 mediates necroptosis by initiating RIPK1–RIPK3–MLKL signal transduction in response to TNF receptor 1 ligation – Zicheng Wang, Jiannan Feng, Jiyun Yu and Guozhu Chen. http://jcs.biologists.org/content/132/10/jcs227777?etoc

Interferon-γ induces the cell surface exposure of phosphatidylserine by activating MLKL in the absence of caspase-8 activity – Jiancheng Chen, Shunsuke Kuroki, Masataka Someda and Shin Yonehara. http://www.jbc.org/content/early/2019/06/19/jbc.RA118.007161.abstract


Ferroptosis


Ferroptotic cell death and TLR4/Trif signaling initiate neutrophil recruitment after heart transplantation – Wenjun Li, Guoshuai Feng, Jason M. Gauthier, Inessa Lokshina, Ryuji Higashikubo, Sarah Evans, Xinping Liu, Adil Hassan, Satona Tanaka, Markus Cicka, Hsi-Min Hsiao, Daniel Ruiz-Perez, Andrea Bredemeyer, Richard W. Gross, Douglas L. Mann, Yulia Y. Tyurina, Andrew E. Gelman, Valerian E. Kagan, Andreas Linkermann, Kory J. Lavine and Daniel Kreisel. https://www.jci.org/articles/view/126428


Miscellanous


A conserved CCM complex promotes apoptosis non-autonomously by regulating zinc homeostasis – Eric M. Chapman, Benjamin Lant, Yota Ohashi, Bin Yu, Michael Schertzberg, Christopher Go, Deepika Dogra, Janne Koskimäki, Romuald Girard, Yan Li, Andrew G. Fraser, Issam A. Awad, Salim Abdelilah-Seyfried, Anne-Claude Gingras and W. Brent Derry. https://www.nature.com/articles/s41467-019-09829-z

Discerning the mechanism of action of HtrA4: a serine protease implicated in the cell death pathway – Raghupathi Kummari, Shubhankar Dutta, Lalith K. Chaganti and Kakoli Bose. http://www.biochemj.org/content/476/10/1445?etoc

AIF-regulated oxidative phosphorylation supports lung cancer development – Shuan Rao, Laura Mondragón, Blanka Pranjic, Toshikatsu Hanada, Gautier Stoll, Thomas Köcher, Peng Zhang, Alexander Jais, Alexander Lercher, Andreas Bergthaler, Daniel Schramek, Katharina Haigh, Valentina Sica, Marion Leduc, Nazanine Modjtahedi, Tsung-Pin Pai, Masahiro Onji, Iris Uribesalgo, Reiko Hanada, Ivona Kozieradzki, Rubina Koglgruber, Shane J. Cronin, Zhigang She, Franz Quehenberger, Helmut Popper, Lukas Kenner, Jody J. Haigh, Oliver Kepp, Malgorzata Rak, Kaican Cai, Guido Kroemer and Josef M. Penninger. https://www.nature.com/articles/s41422-019-0181-4


Reviews


Caspases in Cell Death, Inflammation, and Disease – Nina Van Opdenbosch, Mohamed Lamkanfi. https://www.cell.com/immunity/fulltext/S1074-7613(19)30240-7

Targeting Ferroptosis to Iron Out Cancer – Behrouz Hassannia, Peter Vandenabeele, Tom Vanden Berghe. https://www.cell.com/cancer-cell/fulltext/S1535-6108(19)30197-7

Ferroptosis at the crossroads of cancer-acquired drug resistance and immune evasion – José Pedro Friedmann Angeli, Dmitri V. Krysko and Marcus Conrad. https://www.nature.com/articles/s41568-019-0149-1

Molecular Comprehension of Mcl-1: From Gene Structure to Cancer Therapy – Viacheslav V. Senichkin, Alena Y. Streletskaia, Boris Zhivotovsky, Gelina S. Kopeina. https://www.cell.com/trends/cell-biology/fulltext/S0962-8924(19)30047-9

Autophagy-Independent Functions of the Autophagy Machinery – Lorenzo Galluzzi, Douglas R. Green. https://www.cell.com/cell/fulltext/S0092-8674(19)30554-9

FAIM: An Antagonist of Fas-Killing and Beyond – Jianxin Huo, Shengli Xu and Kong-Peng Lam. https://www.mdpi.com/2073-4409/8/6/541


Comments


Mitochondria and pathogen immunity: from killer to firestarter – Joel S Riley, Stephen WG Tait. https://www.embopress.org/doi/full/10.15252/embj.2019102325

Bayonets over bombs: RIPK3 and MLKL restrict Listeria without triggering necroptosis – Ting Zhang, Siddharth Balachandran. http://jcb.rupress.org/content/218/6/1773?etoc

A New Current for the Mitochondrial Permeability Transition – Massimo Bonora, Paolo Pinton. https://www.cell.com/trends/biochemical-sciences/fulltext/S0968-0004(19)30089-1

Cell Death: N-degrons Fine-Tune Pyroptotic Cell Demise – Mohamed A. Eldeeb, Mohamed A. Ragheb, Edward A. Fon. https://www.cell.com/current-biology/fulltext/S0960-9822(19)30537-8

Death Is Coming and the Clot Thickens, as Pyroptosis Feeds the Fire – Laura C. Burzynski, Murray C.H. Clarke. https://www.cell.com/immunity/fulltext/S1074-7613(19)30235-3

Cancer and the death domain – Wei Wong. https://stke.sciencemag.org/content/12/584/eaay2357


Retraction 

Bax channel triplet: co-operativity and voltage gating – Shang H. Lin, Nuval Cherian, Benjamin Wu, Hyo Phee, Christy Cho and Marco Colombini. http://www.biochemj.org/content/476/10/1571?etoc