ApoList – November 2022


Bcl-2 family proteins


Heightened apoptotic priming of vascular cells across tissues and life span predisposes them to cancer therapy-induced toxicities – Johan K. E. Spetz, Mary H. C. Florido, Cameron S. Fraser, Xingping Qin, Jonathan Choiniere, Stacey J. Yu, Rumani Singh, Max Friesen, Lee L. Rubin, Joe-Elie Salem, Javid J. Moslehi, Kristopher A. Sarosiek. https://www.science.org/doi/full/10.1126/sciadv.abn6579

A Mesenchymal Tumor Cell State Confers Increased Dependency on the BCL-XL Antiapoptotic Protein in Kidney Cancer – Treg Grubb, Smruthi Maganti, John Michael Krill-Burge, Cameron Fraser, Laura Stransky, Tomas Radivoyevitch, Kristopher A. Sarosiek, Francisca Vazquez, William G. Kaelin, Jr, Abhishek A. Chakraborty. https://aacrjournals.org/clincancerres/article-abstract/28/21/4689/709828

Modulation of Ca2+ signaling by antiapoptotic Bcl-2 versus Bcl-xL: From molecular mechanisms to relevance for cancer cell survival – Nicolas Rosa, Femke Speelman-Rooms, Jan B. Parys, Geert Bultynck. https://www.sciencedirect.com/science/article/abs/pii/S0304419X22001160

Reciprocal effects of mTOR inhibitors on pro-survival proteins dictate therapeutic responses in tuberous sclerosis complex – McNamara MC, Hosios AM, Torrence ME, Zhao T, Fraser C, Wilkinson M, Kwiatkowski DJ, Henske EP, Wu CL, Sarosiek KA, Valvezan AJ, Manning BD.. https://www.cell.com/iscience/fulltext/S2589-0042(22)01730-8

SRSF6 balances mitochondrial-driven innate immune outcomes through alternative splicing of BAX – Allison R Wagner, Chi G Weindel, Kelsi O West, Haley M Scott, Robert O Watson, Kristin L Patrick. https://elifesciences.org/articles/82244

Microfluidic-based dynamic BH3 profiling predicts anticancer treatment efficacy – Albert Manzano-Muñoz, José Yeste, María A. Ortega, Fernando Martín, Anna López, Jordi Rosell, Sandra Castro, César Serrano, Josep Samitier, Javier Ramón-Azcón and Joan Montero. https://www.nature.com/articles/s41698-022-00333-0


Death receptors and RIPK


cFLIP suppression and DR5 activation sensitize senescent cancer cells to senolysis – Liqin Wang, Haojie Jin, Fleur Jochems, Siying Wang, Cor Lieftink, Isabel Mora Martinez, Giulia De Conti, Finn Edwards, Rodrigo Leite de Oliveira, Arnout Schepers, Yangyang Zhou, Jiaojiao Zheng, Wei Wu, Xingling Zheng, Shengxian Yuan, Jing Ling, Kathy Jastrzebski, Matheus Dos Santos Dias, Ji-Ying Song, Patrick N. H. Celie, Hideo Yagita, Ming Yao, Weiping Zhou, Roderick L. Beijersbergen, Wenxin Qin and René Bernards. https://www.nature.com/articles/s43018-022-00462-2

An orally active, small-molecule TNF inhibitor that disrupts the homotrimerization interface improves inflammatory arthritis in mice – Nasir Javaid, Mahesh Chandra Patra, Da-Eun Cho, Maria Batool, Yoongeun Kim, Gwang Muk Choi, Moon Suk Kim, Dae-Hyun Hahm, Sangdun Choi. https://www.science.org/doi/abs/10.1126/scisignal.abi8713

SENP1 prevents steatohepatitis by suppressing RIPK1-driven apoptosis and inflammation – Lingjie Yan, Tao Zhang, Kai Wang, Zezhao Chen, Yuanxin Yang, Bing Shan, Qi Sun, Mengmeng Zhang, Yichi Zhang, Yedan Zhong, Nan Liu, Jinyang Gu and Daichao Xu. https://www.nature.com/articles/s41467-022-34993-0

Generative deep learning enables the discovery of a potent and selective RIPK1 inhibitor – Yueshan Li, Liting Zhang, Yifei Wang, Jun Zou, Ruicheng Yang, Xinling Luo, Chengyong Wu, Wei Yang, Chenyu Tian, Haixing Xu, Falu Wang, Xin Yang, Linli Li and Shengyong Yang. https://www.nature.com/articles/s41467-022-34692-w

Tyrosine phosphorylation regulates RIPK1 activity to limit cell death and inflammation – Hailin Tu, Weihang Xiong, Jie Zhang, Xueqiang Zhao and Xin Lin. https://www.nature.com/articles/s41467-022-34080-4


Caspases / Apaf-1


Caspase-8 inactivation drives autophagy-dependent inflammasome activation in myeloid cells – Yung-Hsuan Wu, Shu-Ting Mo, I-Ting Chen, Fu-Yi Hsieh, Shie-Liang Hsieh, Jinake Zhang, Ming-Zong Lai. https://www.science.org/doi/full/10.1126/sciadv.abn9912

Targeting the MITF/APAF-1 axis as salvage therapy for MAPK inhibitors in resistant melanoma – Pietro Carotenuto, Alessia Romano. . Anna Barbato. Paola Quadrano. Simona Brillante. Mariagrazia Volpe. Luigi Ferrante,  Roberta Tammaro, Manuela Morleo, Rossella De Cegli, Antonella Iuliano, Marialuisa Testa, Fabrizio Andreone,  Gennaro Ciliberto, Eduardo Clery, Giancarlo Troncone. Giuseppe Palma, Claudio Arra. Antonio Barbieri, Mariaelena Capone. Gabriele Madonna, Paolo A. Ascierto. Luisa Lanfrancone, Alessia Indrieri, Brunella Franco. https://www.cell.com/cell-reports/fulltext/S2211-1247(22)01466-8

Genuine selective caspase-2 inhibition with new irreversible small peptidomimetics – Elodie Bosc, Julie Anastasie, Feryel Soualmia, Pascale Coric, Ju Youn Kim, Lily Q. Wang, Gullen Lacin, Kaitao Zhao, Ronak Patel, Eric Duplus, Philippe Tixador, Andrew A. Sproul, Bernard Brugg, Michelle Reboud-Ravaux, Carol M. Troy, Michael L. Shelanski, Serge Bouaziz, Michael Karin, Chahrazade El Amri and Etienne D. Jacotot. https://www.nature.com/articles/s41419-022-05396-2

Neurovascular injury associated non-apoptotic endothelial caspase-9 and astroglial caspase-9 mediate inflammation and contrast sensitivity decline – Crystal Colón Ortiz, Albertine M. Neal, Maria I. Avrutsky, Monica Choi, Jade Smart, Jacqueline Lawson & Carol M. Troy. https://www.nature.com/articles/s41419-022-05387-3


Pyroptosis


Sublytic gasdermin-D pores captured in atomistic molecular simulations – Stefan L Schaefer, Gerhard Hummer. https://elifesciences.org/articles/81432

Nuclear translocation of Gasdermin D sensitizes colorectal cancer to chemotherapy in a pyroptosis-independent manner – Xiao Peng, Risi Na, Wenting Zhou, Xiaole Meng, Yunhai Yang, Shohreh Amini and Liwei Song. https://www.nature.com/articles/s41388-022-02503-7


Ferroptosis


Ferroptosis of tumour neutrophils causes immune suppression in cancer – Rina Kim, Ayumi Hashimoto, Nune Markosyan, Vladimir A. Tyurin, Yulia Y. Tyurina, Gozde Kar, Shuyu Fu, Mohit Sehgal, Laura Garcia-Gerique, Andrew Kossenkov, Bereket A. Gebregziabher, John W. Tobias, Kristin Hicks, Rebecca A. Halpin, Nevena Cvetesic, Hui Deng, Laxminarasimha Donthireddy, Andrew Greenberg, Brian Nam, Robert H. Vonderheide, Yulia Nefedova, Valerian E. Kagan and Dmitry I. Gabrilovich. https://www.nature.com/articles/s41586-022-05443-0

Doxorubicin causes ferroptosis and cardiotoxicity by intercalating into mitochondrial DNA and disrupting Alas1-dependent heme synthesis – Ko Abe, Masataka Ikeda, Tomomi Ide, Tomonori Tadokoro, Hiroko Deguchi Miyamoto, Shun Furusawa, Yoshitomo Tsutsui, Ryo Miyake, Kosei Ishimaru, Masatsugu Watanabe, Shouji Matsushima, Tomoko Koumura, Ken-ichi Yamada, Hirotaka Imai, Hiroyuki Tsutsui. https://www.science.org/doi/abs/10.1126/scisignal.abn8017


Miscellanous


Colon tumour cell death causes mTOR dependence by paracrine P2X4 stimulation – Mark Schmitt, Fatih Ceteci, Jalaj Gupta, Marina Pesic, Tim W. Böttger, Adele M. Nicolas, Kilian B. Kennel, Esther Engel, Matthias Schewe, Asude Callak Kirisözü, Valentina Petrocelli, Yasamin Dabiri, Julia Varga, Mallika Ramakrishnan, Madina Karimova, Andrea Ablasser, Toshiro Sato, Melek C. Arkan, Frederic J. de Sauvage and Florian R. Greten. https://www.nature.com/articles/s41586-022-05426-1


Reviews


Mitochondria and cell death-associated inflammation – Esmee Vringer and Stephen W. G. Tait. https://www.nature.com/articles/s41418-022-01094-w

T cell-mediated additive cytotoxicity – death by multiple bullets – Bettina Weigelin, Peter Friedl. https://www.cell.com/trends/cancer/fulltext/S2405-8033(22)00160-1

Extrinsic cell death pathway plasticity: a driver of clonal evolution in cancer? – Eric Seidel and Silvia von Karstedt. https://www.nature.com/articles/s41420-022-01251-7

Signaling pathways and defense mechanisms of ferroptosis – Jiao Liu, Rui Kang, Daolin Tang. https://febs.onlinelibrary.wiley.com/doi/full/10.1111/febs.16059

Balancing life and death: BCL‐2 family members at diverse ER–mitochondrial contact sites – Robert E. Means, Samuel G. Katz. https://febs.onlinelibrary.wiley.com/doi/full/10.1111/febs.16241


Comments


XL-ing at Induction of Apoptosis in Kidney Cancer through Inhibition of BCL-XL – Naitao Wang, A. Ari Hakimi, Yu Chen. https://aacrjournals.org/clincancerres/article-abstract/28/21/4600/709829

A cFLIP-flop switch for senolysis – Dorothy N. Y. Fan and Clemens A. Schmitt. https://www.nature.com/articles/s43018-022-00455-1

BH3-Mimetic Tolerance Is Driven by Sublethal Cytochrome c Release. https://aacrjournals.org/cancerdiscovery/article-abstract/12/11/OF7/709980

Glucose Metabolism in TAMs Promotes Metastasis and Drug Resistance. https://aacrjournals.org/cancerdiscovery/article-abstract/12/11/2495/710000

ApoList – October 2022


Bcl-2 family proteins


Sublethal cytochrome c release generates drug-tolerant persister cells – Halime Kalkavan, Mark J. Chen, Jeremy C. Crawford, Giovanni Quarato, Patrick Fitzgerald, Stephen W.G. Tait, Colin R. Goding, Douglas R. Green. https://www.cell.com/cell/fulltext/S0092-8674(22)00978-3

Apoptotic priming is defined by the dynamic exchange of Bcl-2 proteins between mitochondria and cytosol – Louise E. King, Ricardo Rodriguez-Enriquez, Robert Pedley, Charlotte E. L. Mellor, Pengbo Wang, Egor Zindy, Michael R. H. White, Keith Brennan and Andrew P. Gilmore. https://www.nature.com/articles/s41418-022-01013-z

Alternative splicing of apoptosis genes promotes human T cell survival – Davia Blake, Caleb M Radens, Max B Ferretti, Matthew R Gazzara, Kristen W Lynch. https://elifesciences.org/articles/80953

BOK controls ER proteostasis and physiological ER stress responses in neurons – Franziska Walter, Beatrice D’Orsi, Anagha Jagannathan, Heiko Dussmann and Jochen H. M. Prehn. https://www.frontiersin.org/articles/10.3389/fcell.2022.915065/full

MCL-1 is a master regulator of cancer dependency on fatty acid oxidation – Michelle S. Prew, Utsarga Adhikary, Dong Wook Choi, Erika P. Portero, Joao A. Paulo, Pruthvi Gowda, Amit Budhraja, Joseph T. Opferman, Steven P. Gygi, Nika N. Danial, Loren D. Walensky. https://www.cell.com/cell-reports/fulltext/S2211-1247(22)01286-4

Decoding the concealed transcriptional signature of the apoptosis-related BCL2 antagonist/killer 1 (BAK1) gene in human malignancies – Konstantina Athanasopoulou, Panagiotis G. Adamopoulos, Glykeria N. Daneva and Andreas Scorilas. https://link.springer.com/article/10.1007/s10495-022-01753-w

c-Myc plays a critical role in the antileukemic activity of the Mcl-1-selective inhibitor AZD5991 in acute myeloid leukemia – Shuang Liu, Xinan Qiao, Shuangshuang Wu, Yuqinq Gai, Yongwei Su, Holly Edwards, Yue Wang, Hai Lin, Jeffrey W. Taub, Guan Wang, Yubin Ge. https://link.springer.com/article/10.1007/s10495-022-01756-7

A novel BH3 mimetic Bcl-2 inhibitor promotes autophagic cell death and reduces in vivo Glioblastoma tumor growth – Seyma Calis, Berna Dogan, Serdar Durdagi, Asuman Celebi, Ozlem Yapicier, Turker Kilic, Eda Tahir Turanli and Timucin Avsar, https://www.nature.com/articles/s41420-022-01225-9

Splicing factor BUD31 promotes ovarian cancer progression through sustaining the expression of anti-apoptotic BCL2L12 – Zixiang Wang, Shourong Wang, Junchao Qin, Xiyu Zhang, Gang Lu, Hongbin Liu, Haiyang Guo, Ligang Wu, Victoria O. Shender, Changshun Shao, Beihua Kong and Zhaojian Liu. https://www.nature.com/articles/s41467-022-34042-w


Death receptors


Limiting glutamine utilization activates a GCN2/TRAIL-R2/Caspase-8 apoptotic pathway in glutamine-addicted tumor cells – Rosario Yerbes, Rocío Mora-Molina, F. Javier Fernández-Farrán, Laura Hiraldo, Abelardo López-Rivas and Carmen Palacios. https://www.nature.com/articles/s41419-022-05346-y

MMP7 cleavage of amino-terminal CD95 death receptor switches signaling toward non-apoptotic pathways – Shoji F. Kenji, Keerthi Kurma, Brigitte Collet, Christelle Oblet, Laure Debure, Carmelo Di Primo, Laëtitia Minder, Franck Vérité, Yannic Danger, Mickael Jean, Aubin Penna, Nicolas Levoin and Patrick Legembre. https://www.nature.com/articles/s41419-022-05352-0

Phase I trial of the TNF-α inhibitor certolizumab plus chemotherapy in stage IV lung adenocarcinomas – Paul K. Paik, Jia Luo, Ni Ai, Rachel Kim, Linda Ahn, Anup Biswas, Courtney Coker, Wanchao Ma, Phillip Wong, Darren J. Buonocore, W. Victoria Lai, Jamie E. Chaft, Swarnali Acharyya, Joan Massagué and Mark G. Kris. https://www.nature.com/articles/s41467-022-33719-6

Escaping cell death via TRAIL decoy receptors: a systematic review of their roles and expressions in colorectal cancer – Kelly Xue Jing Jong, Elsa Haniffah Mejia Mohamed and Zaridatul Aini Ibrahim. https://link.springer.com/article/10.1007/s10495-022-01774-5


Caspases


PIDDosome-SCAP crosstalk controls high-fructose-diet-dependent transition from simple steatosis to steatohepatitis – Ju Youn Kim, Lily Q. Wang, Valentina C. Sladky, Tae Gyu Oh, Junlai Liu, Kaitlyn Trinh, Felix Eichin, Michael Downes, Mojgan Hosseini, Etienne D. Jacotot, Ronald M. Evans, Andreas Villunger, Michael Karin. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(22)00348-5

Molecular mechanism of RIPK1 and caspase-8 in homeostatic type I interferon production and regulation – Yaqiu Wang, Rajendra Karki, Raghvendra Mall, Bhesh Raj Sharma, Ravi C. Kalathur, SangJoon Lee, Balabhaskararao Kancharana, Matthew So, Katie L. Combs, Thirumala-Devi Kanneganti. https://www.cell.com/cell-reports/fulltext/S2211-1247(22)01275-X


Necroptosis


Caspase-8 and FADD prevent spontaneous ZBP1 expression and necroptosis – Diego A. Rodriguez, Giovanni Quarato, Swantje Liedmann, Bart Tummers, Ting Zhang, Cliff Guy, Jeremy Chase Crawford, Gustavo Palacios, Stephane Pelletier, Halime Kalkavan, Jeremy J. P. Shaw, Patrick Fitzgerald, Mark J. Chen, Siddharth Balachandran and Douglas R. Green. https://www.pnas.org/doi/10.1073/pnas.2207240119

Human ZBP1 induces cell death-independent inflammatory signaling via RIPK3 and RIPK1 – Ruoshi Peng, Chris Kedong Wang, Xuan Wang-Kan, Manja Idorn, Majken Kjær, Felix Y Zhou, Berthe Katrine Fiil, Frederik Timmermann, Susana L Orozco, Julia McCarthy, Carol S Leung, Xin Lu, Katrin Bagola, Jan Rehwinkel, Andrew Oberst, Jonathan Maelfait, Søren R Paludan, Mads Gyrd-Hansen. https://www.embopress.org/doi/full/10.15252/embr.202255839


Pyroptosis


GSDMD drives canonical inflammasome‐induced neutrophil pyroptosis and is dispensable for NETosis – Dhruv Chauhan, Dieter Demon, Lieselotte Vande Walle, Oonagh Paerewijck, Annalisa Zecchin, Leslie Bosseler, Karin Santoni, Rémi Planès, Silvia Ribo, Amelie Fossoul, Amanda Gonçalves, Hanne Van Gorp, Nina Van Opdenbosch, Filip Van Hauwermeiren, Etienne Meunier, Andy Wullaert, Mohamed Lamkanfi. https://www.embopress.org/doi/abs/10.15252/embr.202154277

Gasdermin D restricts anti-tumor immunity during PD-L1 checkpoint blockade – Yuying Jiang, Yongbing Yang, Yingchao Hu, Rui Yang, Jiajia Huang, Yi Liu, Yuqing Wu, Sheng Li, Chunmei Ma, Fiachra Humphries, Bingwei Wang, Xi Wang, Zhibin Hu, Shuo Yang. https://www.cell.com/cell-reports/fulltext/S2211-1247(22)01409-7

GSDME deficiency leads to the aggravation of UVB-induced skin inflammation through enhancing recruitment and activation of neutrophils – Yujie Chen, Ni Lian, Sihan Chen, Ta Xiao, Yangying Ke, Yiqun Zhang, Changjun Song, Yong Yang, Song Xu, Heng Gu and Xu Chen. https://www.nature.com/articles/s41419-022-05276-9

Enhancing Gasdermin-induced tumor pyroptosis through preventing ESCRT-dependent cell membrane repair augments antitumor immune response – Zhaoting Li, Fanyi Mo, Yixin Wang, Wen Li, Yu Chen, Jun Liu, Ting-Jing Chen-Mayfield and Quanyin Hu. https://www.nature.com/articles/s41467-022-34036-8


Ferroptosis


Selective ferroptosis vulnerability due to familial Alzheimer’s disease presenilin mutations – Mark A. Greenough, Darius J. R. Lane, Rachelle Balez, Helena Targa Dias Anastacio, Zhiwen Zeng, Katherine Ganio, Christopher A. McDevitt, Karla Acevedo, Abdel Ali Belaidi, Jari Koistinaho, Lezanne Ooi, Scott Ayton and Ashley I. Bush. https://www.nature.com/articles/s41418-022-01003-1

Doxorubicin causes ferroptosis and cardiotoxicity by intercalating into mitochondrial DNA and disrupting Alas1-dependent heme synthesis – Ko Abe, Masataka Ikeda, Tomomi Ide, Tomonori Tadokoro, Hiroko Deguchi Miyamoto, Shun Furusawa, Yoshitomo Tsutsui, Ryo Miyake, Kosei Ishimaru, Masatsugu Watanabe, Shouji Matsushima, Tomoko Koumura, Ken-ichi Yamada, Hirotaka Imai, Hiroyuki Tsutsui. https://www.science.org/doi/abs/10.1126/scisignal.abn8017


Efferocytosis, entosis, phagoptosis etc


Mobilizing phospholipids on tumor plasma membrane implicates phosphatidylserine externalization blockade for cancer immunotherapy – Weihong Wang, Shaoxian Wu, Zhanpeng Cen, Yixin Zhang, Yuang Chen, Yixian Huang, Anthony R. Cillo, Joshua S. Prokopec, Giovanni Quarato, Dario A.A. Vignali, Jacob Stewart-Ornstein, Song Li, Binfeng Lu, Yi-Nan Gong. https://www.cell.com/cell-reports/fulltext/S2211-1247(22)01447-4

Non-autonomous cell death induced by the Draper phagocytosis receptor requires signaling through the JNK and SRC pathways – Sandy B. Serizier; Jeanne S. Peterson; Kimberly McCall. https://journals.biologists.com/jcs/article-abstract/135/20/jcs250134/278232


Reviews


Understanding MCL1: from cellular function and regulation to pharmacological inhibition – Mónica Sancho, Diego Leiva, Estefanía Lucendo, Mar Orzáez. https://febs.onlinelibrary.wiley.com/doi/full/10.1111/febs.16136

Dying in self-defence: a comparative overview of immunogenic cell death signalling in animals and plants – Takaki Maekawa, Hamid Kashkar and Núria S. Coll. https://www.nature.com/articles/s41418-022-01060-6

Stressed to death: Mitochondrial stress responses connect respiration and apoptosis in cancer – Jacob M. Winter, Tarun Yadav, Jared Rutter. https://www.cell.com/molecular-cell/fulltext/S1097-2765(22)00708-0

What role does pyroptosis play in cancer? – Chen Huang, Jian Li, Chenliang Zhang. https://www.sciencedirect.com/science/article/pii/S2212877822001569


Comments


Cap CASP, not SCAP, to fight steatohepatitis – Wolfram Goessling. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(22)00404-1

Vitamin K: A new guardian against ferroptosis – Tal Hirschhorn, Brent R. Stockwell. https://www.cell.com/molecular-cell/fulltext/S1097-2765(22)00958-3

Persisting through apoptosis – Michael Attwaters. https://www.nature.com/articles/s41580-022-00544-0

ApoList – September 2022


Bcl-2 family proteins


Small molecule SJ572946 activates BAK to initiate apoptosis – Giridhar Sekar, Geetika Singh, Xingping Qin, Cristina D. Guibao, Brittany Schwam, Zintis Inde, Christy R. Grace, Weixing Zhang, P. Jake Slavish, Wenwei Lin, Taosheng Chen, Richard E. Lee, Zoran Rankovic, Kristopher Sarosiek, Tudor Moldoveanu. https://www.cell.com/iscience/fulltext/S2589-0042(22)01336-0

Structure of the BAK-activating antibody 7D10 bound to BAK reveals an unexpected role for the α1-α2 loop in BAK activation – Adeline Y. Robin, Michelle S. Miller, Sweta Iyer, Melissa X. Shi, Ahmad Z. Wardak, Daisy Lio, Nicholas A. Smith, Brian J. Smith, Richard W. Birkinshaw, Peter E. Czabotar, Ruth M. Kluck and Peter M. Colman. https://www.nature.com/articles/s41418-022-00961-w

BET inhibition induces vulnerability to MCL1 targeting through upregulation of fatty acid synthesis pathway in breast cancer – Gonghong Yan, Augustin Luna, Heping Wang, Behnaz Bozorgui, Xubin Li, Maga Sanchez, Zeynep Dereli, Nermin Kahraman, Goknur Kara, Xiaohua Chen, Caishang Zheng, Daniel McGrail, Nidhi Sahni, Yiling Lu, Ozgun Babur, Murat Cokol, Bora Lim, Bulent Ozpolat, Chris Sander, Gordon B. Mills, Anil Korkut. https://www.cell.com/cell-reports/fulltext/S2211-1247(22)01128-7

Chlamydia trachomatis inhibits apoptosis in infected cells by targeting the pro-apoptotic proteins Bax and Bak – Collins Waguia Kontchou, Ian E. Gentle, Arnim Weber, Axel Schoeniger, Frank Edlich and Georg Häcker. https://www.nature.com/articles/s41418-022-00995-0

Exploiting endogenous and therapy-induced apoptotic vulnerabilities in immunoglobulin light chain amyloidosis with BH3 mimetics – Cameron S. Fraser, Johan K. E. Spetz, Xingping Qin, Adam Presser, Jonathan Choiniere, Chendi Li, Stacey Yu, Frances Blevins, Aaron N. Hata, Jeffrey W. Miller, Gary A. Bradshaw, Marian Kalocsay, Vaishali Sanchorawala, Shayna Sarosiek and Kristopher A. Sarosiek. https://www.nature.com/articles/s41467-022-33461-z


Death receptors


PP6 negatively modulates LUBAC-mediated M1-ubiquitination of RIPK1 and c-FLIPL to promote TNFα-mediated cell death – Guowei Wu, Dekang Li, Wei Liang, Weimin Sun, Xingxing Xie, Yilun Tong, Bing Shan, Mengmeng Zhang, Xiaojuan Lu, Junying Yuan and Ying Li. https://www.nature.com/articles/s41419-022-05206-9


Caspases


Caspase-3–Induced Activation of SREBP2 Drives Drug Resistance via Promotion of Cholesterol Biosynthesis in Hepatocellular Carcinoma – Etienne Ho Kit Mok, Carmen Oi Ning Leung, Lei Zhou, Martina Mang Leng Lei, Hoi Wing Leung, Man Tong, Tin Lok Wong, Eunice Yuen Ting Lau, Irene Oi Lin Ng, Jin Ding, Jing Ping Yun, Jun Yu, Hui Lian Zhu, Chi Ho Lin, Dan Lindholm, Kit Sum Leung, Jonathan D. Cybulski, David M. Baker, Stephanie M, Terence Kin Wah Lee. https://aacrjournals.org/cancerres/article-abstract/82/17/3102/708279

Coronaviruses exploit a host cysteine-aspartic protease for replication – Hin Chu, Yuxin Hou, Dong Yang, Lei Wen, Huiping Shuai, Chaemin Yoon, Jialu Shi, Yue Chai, Terrence Tsz-Tai Yuen, Bingjie Hu, Cun Li, Xiaoyu Zhao, Yixin Wang, Xiner Huang, Kin Shing Lee, Cuiting Luo, Jian-Piao Cai, Vincent Kwok-Man Poon, Chris Chung-Sing Chan, Anna Jinxia Zhang, Shuofeng Yuan, Ko-Yung Sit, Dominic Chi-Chung Foo, Wing-Kuk Au, Kwok-Yung Yuen. https://www.nature.com/articles/s41586-022-05148-4


Necroptosis


Membrane permeabilization is mediated by distinct epitopes in mouse and human orthologs of the necroptosis effector, MLKL – Ashish Sethi, Christopher R. Horne, Cheree Fitzgibbon, Karyn Wilde, Katherine A. Davies, Sarah E. Garnish, Annette V. Jacobsen, André L. Samson, Joanne M. Hildebrand, Ahmad Wardak, Peter E. Czabotar, Emma J. Petrie, Paul R. Gooley and James M. Murphy. https://www.nature.com/articles/s41418-022-00965-6

https://journals.biologists.com/jcs/article-abstract/135/17/jcs260091/276621


Pyroptosis


Gasdermin D-deficient mice are hypersensitive to acute kidney injury – Wulf Tonnus, Francesca Maremonti, Alexia Belavgeni, Markus Latk, Yoshihiro Kusunoki, Anne Brucker, Anne von Mässenhausen, Claudia Meyer, Sophie Locke, Florian Gembardt, Kristina Beer, Paul Hoppenz, Jan U. Becker, Christian Hugo, Hans-Joachim Anders, Stefan R. Bornstein, Feng Shao and Andreas Linkermann. https://www.nature.com/articles/s41419-022-05230-9


Ferroptosis


The MARCHF6 E3 ubiquitin ligase acts as an NADPH sensor for the regulation of ferroptosis – Kha The Nguyen, Sang-Hyeon Mun, Jihye Yang, Jongeun Lee, Ok-Hee Seok, Eunjeong Kim, Dasom Kim, So Young An, Dong-Young Seo, Jeong-Yong Suh, Yoontae Lee and Cheol-Sang Hwang. https://www.nature.com/articles/s41556-022-00973-1


Miscellanous


Induction of tumor cell autosis by myxoma virus-infected CAR-T and TCR-T cells to overcome primary and acquired resistance – Ningbo Zheng, Jing Fang, Gang Xue, Ziyu Wang, Xiaoyin Li, Mengshi Zhou, Guangxu Jin, Masmudur M. Rahman, Grant McFadden, Yong Lu. https://www.cell.com/cancer-cell/fulltext/S1535-6108(22)00357-9

NRF2 mediates melanoma addiction to GCDH by modulating apoptotic signalling – Sachin Verma, David Crawford, Ali Khateb, Yongmei Feng, Eduard Sergienko, Gaurav Pathria, Chen-Ting Ma, Steven H. Olson, David Scott, Rabi Murad, Eytan Ruppin, Michael Jackson and Ze’ev A. Ronai.  https://www.nature.com/articles/s41556-022-00985-x


Reviews


Necroptosis at a glance – Kidong Kang, Christa Park, Francis Ka-Ming Chan. https://journals.biologists.com/jcs/article-abstract/135/17/jcs260091/276621

MLKL post-translational modifications: road signs to infection, inflammation and unknown destinations – Gianmaria Liccardi and Alessandro Annibaldi. https://www.nature.com/articles/s41418-022-01061-5

Monitoring yeast regulated cell death: trespassing the point of no return to loss of plasma membrane integrity – António Rego, António Ribeiro, Manuela Côrte-Real, Susana Rodrigues Chaves. https://link.springer.com/article/10.1007/s10495-022-01748-7


Comments


A conversation with Vishva Dixit – Ushma S. Neill. https://www.jci.org/articles/view/164341

Navigating ferroptosis via an NADPH sensor – Chao Mao and Boyi Gan. https://www.nature.com/articles/s41556-022-00963-3

The power of an idea: Andrew Wyllie – Richard A. Lockshin and Margaret C. Cummings

https://www.nature.com/articles/s41418-022-01043-7

Pro-ferroptotic fatty acid metabolism renders cancer cells immunogenic – Oliver Kepp, Guido Kroemer. https://www.cell.com/trends/cancer/fulltext/S2405-8033(22)00089-9

ApoList – July/August 2022


Bcl-2 family proteins


The BCL‐2 family member BID plays a role during embryonic development in addition to its BH3‐only protein function by acting in parallel to BAX, BAK and BOK – Francine S Ke, Steven Holloway, Rachel T Uren, Agnes W Wong, Melissa H Little, Ruth M Kluck, Anne K Voss, Andreas Strasser. https://www.embopress.org/doi/abs/10.15252/embj.2021110300

Ca2+-mediated mitochondrial inner membrane permeabilization induces cell death independently of Bax and Bak – Giovanni Quarato, Fabien Llambi, Cliff S. Guy, Jaeki Min, Marisa Actis, Huan Sun, Shilpa Narina, Shondra M. Pruett-Miller, Junmin Peng, Zoran Rankovic and Douglas R. Green. https://www.nature.com/articles/s41418-022-01025-9

BH3 mimetic drugs cooperate with Temozolomide, JQ1 and inducers of ferroptosis in killing glioblastoma multiforme cells – Diane Moujalled, Adam G. Southon, Eiman Saleh, Kerstin Brinkmann, Francine Ke, Melinda Iliopoulos, Ryan S. Cross, Misty R. Jenkins, Duong Nhu, Zilu Wang, Melissa X. Shi, Ruth M. Kluck, Guillaume Lessene, Stephanie Grabow, Ashley I. Bush and Andreas Strasser. https://www.nature.com/articles/s41418-022-00977-2

BCL-2 isoform β promotes angiogenesis by TRiC-mediated upregulation of VEGF-A in lymphoma – Xiaohang Hang, Lei Zhao, Baohong Wu, Shujun Li, Pengpeng Liu, Jing Xu, Xinyuan Wang, Pengliang Chi, Chong Chen, Ting Niu, Lunzhi Dai and Yu Liu. https://www.nature.com/articles/s41388-022-02372-0

Ceramide-induced integrated stress response overcomes Bcl-2 inhibitor resistance in acute myeloid leukemia – Alexander C. Lewis, Victoria S. Pope, Melinda N. Tea, Manjun Li, Gus O. Nwosu, Thao M. Nguyen, Craig T. Wallington-Beddoe, Paul A. B. Moretti, Dovile Anderson, Darren J. Creek, Maurizio Costabile, Saira R. Ali, Chloe A. L. Thompson-Peach, B. Kate Dredge, Andrew G. Bert, Gregory J. Goodall, Paul G. Ekert, Anna L. Brown, Richard D’Andrea, Nirmal Robinson, Melissa R. Pitman, Daniel Thomas, David M. Ross, Briony L. Gliddon, Jason A. Powell, Stuart M. Pitson. https://ashpublications.org/blood/article/139/26/3737/485003

Structural and biochemical analyses of Bcl-xL in complex with the BH3 domain of peroxisomal testis-specific 1 – Lim D, Jin S, Shin HC, Kim W, Choi JS, Oh DB, Kim SJ, Seo J, Ku B. https://www.sciencedirect.com/science/article/pii/S0006291X22011147?via%3Dihub

A common deletion at BAK1 reduces enhancer activity and confers risk of intracranial germ cell tumors – Kyuto Sonehara, Yui Kimura, Yoshiko Nakano, Tatsuya Ozawa, Meiko Takahashi, Ken Suzuki, Takashi Fujii, Yuko Matsushita, Arata Tomiyama, Toshihiro Kishikawa, Kenichi Yamamoto, Tatsuhiko Naito, Tomonari Suzuki, Shigeru Yamaguchi, Tomoru Miwa, Hikaru Sasaki, Masashi Kitagawa, Naoyuki Ohe, Junya Fukai, Hideki Ogiwara, Atsufumi Kawamura, Satoru Miyawaki, Fumihiko Matsuda, Nobutaka Kiyokawa, Koichi Ichimura, Ryo Nishikawa, Yukinori Okada and Keita Terashima. https://www.nature.com/articles/s41467-022-32005-9


“Death” receptors


TRAIL protects the immature lung from hyperoxic injury – Tayyab Shahzad, Cho-Ming Chao, Stefan Hadzic, Judith Behnke, Luisa Biebach, Eva Böttcher-Friebertshäuser, Jochen Wilhelm, Anne Hilgendorff, Klaus-Peter Zimmer, Rory E. Morty, Saverio Bellusci and Harald Ehrhardt. https://www.nature.com/articles/s41419-022-05072-5

Engagement of TRAIL triggers degranulation and IFNγ production in human natural killer cells – Johannes Höfle, Timo Trenkner, Nadja Kleist, Vera Schwane, Sarah Vollmers, Bryan Barcelona, Annika Niehrs, Pia Fittje, Van Hung Huynh-Tran, Jürgen Sauter, Alexander H Schmidt, Sven Peine, Angelique Hoelzemer, Laura Richert, Marcus Altfeld, Christian Körner. https://www.embopress.org/doi/full/10.15252/embr.202154133

Indomethacin-induced oxidative stress enhances death receptor 5 signaling and sensitizes tumor cells to adoptive T-cell therapy – Nada S Aboelella, Caitlin Brandle, Ogacheko Okoko et al.. https://jitc.bmj.com/content/10/7/e004938

Engineered sTRAIL-armed MSCs overcome STING deficiency to enhance the therapeutic efficacy of radiotherapy for immune checkpoint blockade – Kevin Chih-Yang Huang, Shu-Fen Chiang, Hsin-Yu Chang, William Tzu-Liang Chen, Pei-Chen Yang, Tsung-Wei Chen, Ji-An Liang, An‑Cheng Shiau, Tao-Wei Ke and K. S. Clifford Chao. https://www.nature.com/articles/s41419-022-05069-0

Early B cell factor 4 modulates FAS-mediated apoptosis and promotes cytotoxic function in human immune cells – Satoshi Kubo, Rhea Kataria, Yikun Yao, Justin Q. Gabrielski, Lixin Zheng, Tovah E. Markowitz, Waipan Chan, Jian Song, Arun K. Boddapati, Keita Saeki, Björn Häupl, Ann Y. Park, Yan H. Cheng, Jing Cui, Thomas Oellerich and Michael J. Lenardo. https://www.pnas.org/doi/10.1073/pnas.2208522119

TAK1 Limits Death Receptor Fas-Induced Proinflammatory Cell Death in Macrophages – Kengo Maeda, Jun Nakayama, Shinsuke Taki and Hideki Sanjo. https://www.jimmunol.org/content/early/2022/08/10/jimmunol.2200322


Caspases


Apoptotic caspases suppress an MDA5-driven IFN response during productive replication of human papillomavirus type 31 – Ning Huang, Des’ree Groover, Blossom Damania and Cary Moody. https://www.pnas.org/doi/10.1073/pnas.2200206119

Apoptotic caspase inhibits innate immune signaling by cleaving NF-κBs in both Mammals and Flies – Di Wu, Zhaowei Wang, Jing Zhang, Adam G. Robinson, Bao Lyu, Ziyu Chen, Chong Wang, Bin Wei, Xiaojun Xia, Qing Zhang and Xi Zhou. https://www.nature.com/articles/s41419-022-05156-2

Caspase-8 auto-cleavage regulates programmed cell death and collaborates with RIPK3/MLKL to prevent lymphopenia – Xiaoming Li, Fang Li, Xixi Zhang, Haiwei Zhang, Qun Zhao, Ming Li, Xiaoxia Wu, Lingxia Wang, Jianling Liu, Xuanhui Wu, Yangjing Ou, Mingyan Xing, Yue Zhang, Jiangshan Deng, Xiuzhe Wang, Yan Luo, Jinbao Li, Yuwu Zhao and Haibing Zhang. https://www.nature.com/articles/s41418-022-00938-9

PKR and TLR3 trigger distinct signals that coordinate the induction of antiviral apoptosis – Wenjie Zuo, Mai Wakimoto, Noriyasu Kozaiwa, Yutaro Shirasaka, Seong-Wook Oh, Shiori Fujiwara, Hitoshi Miyachi, Amane Kogure, Hiroki Kato and Takashi Fujita. https://www.nature.com/articles/s41419-022-05101-3


Necroptosis


Mitochondrial ROS promotes susceptibility to infection via gasdermin D-mediated necroptosis – Chi G. Weindel, Eduardo L. Martinez, Xiao Zhao, Cory J. Mabry, Samantha L. Bell, Krystal J. Vail, Aja K. Coleman, Jordyn J. VanPortfliet, Baoyu Zhao, Allison R. Wagner, Sikandar Azam, Haley M. Scott, Pingwei Li, A. Phillip West, Jason Karpac, Kristin L. Patrick, Robert O. Watson. https://www.cell.com/cell/fulltext/S0092-8674(22)00790-5

ADAR1 mutation causes ZBP1-dependent immunopathology – Nicholas W. Hubbard, Joshua M. Ames, Megan Maurano, Lan H. Chu, Kim Y. Somfleth, Nandan S. Gokhale, Margo Werner, Jessica M. Snyder, Katrina Lichauco, Ram Savan, Daniel B. Stetson and Andrew Oberst. https://www.nature.com/articles/s41586-022-04896-7

ADAR1 averts fatal type I interferon induction by ZBP1 – Huipeng Jiao, Laurens Wachsmuth, Simone Wolf, Juliane Lohmann, Masahiro Nagata, Göksu Gökberk Kaya, Nikos Oikonomou, Vangelis Kondylis, Manuel Rogg, Martin Diebold, Simon E. Tröder, Branko Zevnik, Marco Prinz, Christoph Schell, George R. Young, George Kassiotis and Manolis Pasparakis. https://www.nature.com/articles/s41586-022-04878-9

Deficiency of PPP6C protects TNF-induced necroptosis through activation of TAK1 – Yonggang Zou, Qi Zheng, Bin Jiang, Yuning Liu, Yanhua Xu, Liang Ma, Zonghao Hu, Ming Wu & Hai Song. https://www.nature.com/articles/s41419-022-05076-1

Acidosis induces RIPK1-dependent death of glioblastoma stem cells via acid-sensing ion channel 1a – Jan Clusmann, Klaus-Daniel Cortés Franco, David Alejandro Corredor Suárez, Istvan Katona, Maria Girbes Minguez, Nina Boersch, Karolos-Philippos Pissas, Jakob Vanek, Yuemin Tian and Stefan Gründer. https://www.nature.com/articles/s41419-022-05139-3


Pyroptosis


PP1A prevents ROS‐induced pyroptosis by inhibiting MAPK/caspase‐3 in mouse adipose tissue – Yizhe Chen, Meng Che, Chaowei Li, Yizhou Li, Tiantian Zhang, Xinjian Li, Chao Sun. https://febs.onlinelibrary.wiley.com/doi/abs/10.1111/febs.16373?campaign=woletoc


Ferroptosis


ACSL4-dependent ferroptosis does not represent a tumor-suppressive mechanism but ACSL4 rather promotes liver cancer progression – Julia Grube, Marius Maximilian Woitok, Antje Mohs, Stephanie Erschfeld, Celina Lynen, Christian Trautwein and Tobias Otto. https://www.nature.com/articles/s41419-022-05137-5

G9a dictates neuronal vulnerability to inflammatory stress via transcriptional control of ferroptosis – Nicola Rothammer, Marcel S. Woo, Simone Bauer, Lars Binkle-Ladisch, Giovanni Di Liberto, Kristof Egervari, Ingrid Wagner, Undine Haferkamp, Ole Pless, Doron Merkler, Jan Broder Engler, Manuel A. Friese. https://www.science.org/doi/full/10.1126/sciadv.abm5500


Efferocytosis, entosis etc


Efferocytosis of SARS-CoV-2-infected dying cells impairs macrophage anti-inflammatory functions and clearance of apoptotic cells – Ana CG Salina, Douglas dos-Santos, Tamara S Rodrigues, Marlon Fortes-Rocha, Edismauro G Freitas-Filho, Daniel L Alzamora-Terrel, Icaro MS Castro, Thais FC Fraga da Silva, Mikhael HF de Lima, Daniele C Nascimento, Camila M Silva, Juliana E Toller-Kawahisa, Amanda Becerra, Samuel Oliveira, Diego B Caetité, Leticia Almeida, Adriene Y Ishimoto, Thais M Lima, Ronaldo B Martins, Flavio Veras, Natália B do Amaral, Marcela C Giannini, Letícia P Bonjorno, Maria IF Lopes, Maira N Benatti, Sabrina S Batah, Rodrigo C Santana, Fernando C Vilar, Maria A Martins, Rodrigo L Assad, Sergio CL de Almeida, Fabiola R de Oliveira, Eurico Arruda Neto, Thiago M Cunha, José C Alves-Filho, Vania LD Bonato, Fernando Q Cunha, Alexandre T Fabro, Helder I Nakaya, Dario S Zamboni, Paulo Louzada-Junior, Rene DR Oliveira, Larissa D Cunha. https://elifesciences.org/articles/74443

Glycosylation defects, offset by PEPCK-M, drive entosis in breast carcinoma cells – Petra Hyroššová, Marc Aragó, Cristina Muñoz-Pinedo, Francesc Viñals, Pablo M. García-Rovés, Carmen Escolano, Andrés Méndez-Lucas and Jose C. Perales. https://www.nature.com/articles/s41419-022-05177-x

Externalized phosphatidylinositides on apoptotic cells are eat-me signals recognized by CD14 – Ok-Hee Kim, Geun-Hyung Kang, June Hur, Jinwook Lee, YunJae Jung, In-Sun Hong, Hookeun Lee, Seung-Yong Seo, Dae Ho Lee, Cheol Soon Lee, In-Kyu Lee, Susan Bonner-Weir, Jongsoon Lee, Young Joo Park, Hyeonjin Kim, Steven E. Shoelson and Byung-Chul Oh. https://www.nature.com/articles/s41418-022-00931-2

Apoptotic brown adipocytes enhance energy expenditure via extracellular inosine – Birte Niemann, Saskia Haufs-Brusberg, Laura Puetz, Martin Feickert, Michelle Y. Jaeckstein, Anne Hoffmann, Jelena Zurkovic, Markus Heine, Eva-Maria Trautmann, Christa E. Müller, Anke Tönjes, Christian Schlein, Azin Jafari, Holger K. Eltzschig, Thorsten Gnad, Matthias Blüher, Natalie Krahmer, Peter Kovacs, Joerg Heeren and Alexander Pfeifer. https://www.nature.com/articles/s41586-022-05041-0


Miscellanous


Interaction of LATS1 with SMAC links the MST2/Hippo pathway with apoptosis in an IAP-dependent manner – Lucía García-Gutiérrez, Emma Fallahi, Nourhan Aboud, Niall Quinn & David Matallanas. https://www.nature.com/articles/s41419-022-05147-3


Reviews


Death domain fold proteins in immune signaling and transcriptional regulation – Yu-San Huoh, Sun Hur. https://febs.onlinelibrary.wiley.com/doi/full/10.1111/febs.15901

Regulation of innate immune responses by cell death‐associated caspases during virus infection – Yujie Fang, Ke Peng. https://febs.onlinelibrary.wiley.com/doi/full/10.1111/febs.16051

Restoring TRAILR2/DR5-Mediated Activation of Apoptosis upon Endoplasmic Reticulum Stress as a Therapeutic Strategy in Cancer – Rocío Mora-Molina, Abelardo López-Rivas.. https://www.mdpi.com/1422-0067/23/16/8987

Emerging roles of ferroptosis in the tumor immune landscape: from danger signals to anti‐tumor immunity – Lei Shi, Yingqi Liu, Menghuan Li, Zhong Luo. https://febs.onlinelibrary.wiley.com/doi/full/10.1111/febs.16034

Ferroptosis turns 10: Emerging mechanisms, physiological functions, and therapeutic applications – Brent R. Stockwell. https://www.cell.com/cell/fulltext/S0092-8674(22)00708-5

XIAP as a multifaceted molecule in Cellular Signaling – Mina Hanifeh, Farangis Ataei. https://link.springer.com/article/10.1007/s10495-022-01734-z

Programmed cell death detection methods: a systematic review and a categorical comparison – Sana Kari, Kumar Subramanian, Ilenia Agata Altomonte, Akshaya Murugesan, Olli Yli-Harja, Meenakshisundaram Kandhavelu. https://link.springer.com/article/10.1007/s10495-022-01735-y


Comments / other


Remembering apoptosis pioneer Andrew Wyllie (1944–2022) – Christine J. Watson, Gerry Melino, Seamus J. Martin. https://febs.onlinelibrary.wiley.com/doi/full/10.1111/febs.16566

Hold your horses! Reining in your fastest pores with caspase-7 – Jeffrey Y. Zhou, Katherine A. Fitzgerald. https://www.cell.com/immunity/fulltext/S1074-7613(22)00348-X

RIPK1 Promotes Intrinsic and Extrinsic Resistance to Immunotherapy. https://aacrjournals.org/cancerdiscovery/article-abstract/12/7/1607/705209

Lab Meeting: Vishva Dixit. https://dneel.substack.com/p/lab-meeting-vishva-dixit?r=1m5xy3&utm_medium=ios

Conference: “Problems in the Powerhouse: Mitochondrial Dysfunction in Cancer”

Oct. 24/25th. Organizers: Payam Gammage, Stephen Tait , Tom MacVicar. Glasgow, UK

https://www.beatson.gla.ac.uk/Beatson-Workshop-October-2022/programme.html

ApoList – June 2022


Caspases


Caspase-7 activates ASM to repair gasdermin and perforin pores – Kengo Nozaki, Vivien I. Maltez, Manira Rayamajhi, Alan L. Tubbs, Joseph E. Mitchell, Carolyn A. Lacey, Carissa K. Harvest, Lupeng Li, William T. Nash, Heather N. Larson, Benjamin D. McGlaughon, Nathaniel J. Moorman, Michael G. Brown, Jason K. Whitmire and Edward A. Miao. https://www.nature.com/articles/s41586-022-04825-8

Caspase‐8 in endothelial cells maintains gut homeostasis and prevents small bowel inflammation in mice – Nathalie Tisch, Carolin Mogler, Ana Stojanovic, Robert Luck, Emilia A Korhonen, Alexander Ellerkmann, Heike Adler, Mahak Singhal, Géza Schermann, Lena Erkert, Jay V Patankar, Andromachi Karakatsani, Anna-Lena Scherr, Yaron Fuchs, Adelheid Cerwenka, Stefan Wirtz, Bruno Christian Köhler, Hellmut G Augustin, Christoph Becker, Thomas Schmidt, Carmen Ruiz de Almodóvar. https://www.embopress.org/doi/full/10.15252/emmm.202114121

Myeloid caspase-8 restricts RIPK3-dependent proinflammatory IL-1β production and CD4 T cell activation in autoimmune demyelination – Sunja Kim, Hsueh Chung Lu, Andrew J. Steelman and Jianrong Li. https://www.pnas.org/doi/10.1073/pnas.2117636119

Cytoplasmic innate immune sensing by the caspase-4 non-canonical inflammasome promotes cellular senescence – Irene Fernández-Duran, Andrea Quintanilla, Núria Tarrats, Jodie Birch, Priya Hari, Fraser R. Millar, Anthony B. Lagnado, Vanessa Smer-Barreto, Morwenna Muir, Valerie G. Brunton, João F. Passos and Juan Carlos Acosta. https://www.nature.com/articles/s41418-021-00917-6

Mechanistic insights into the activation of the IKK kinase complex by the Kaposi’s sarcoma herpes virus oncoprotein vFLIP – Claire Bagnéris, Swathi L. Senthil Kumar, Mehdi Baratchian, Hannah M. Britt, Tufa E. Assafa, Konstantinos Thalassinos, Mary K. Collins, Tracey E. Barrett. https://www.jbc.org/article/S0021-9258(22)00452-5/fulltext


Necroptosis


Human RIPK3 C-lobe phosphorylation is essential for necroptotic signaling – Yanxiang Meng, Christopher R. Horne, Andre L. Samson, Laura F. Dagley, Samuel N. Young, Jarrod J. Sandow, Peter E. Czabotar and James M. Murphy. https://www.nature.com/articles/s41419-022-05009-y


Pyroptosis


Nanobodies dismantle post‐pyroptotic ASC specks and counteract inflammation in vivo – Damien Bertheloot, Carlos WS Wanderley, Ayda H Schneider, Lisa DJ Schiffelers, Jennifer D Wuerth, Jan MP Tödtmann, Salie Maasewerd, Ibrahim Hawwari, Fraser Duthie, Cornelia Rohland, Lucas S Ribeiro, Lea-Marie Jenster, Nathalia Rosero, Yonas M Tesfamariam, Fernando Q Cunha, Florian I Schmidt, Bernardo S Franklin. https://www.embopress.org/doi/full/10.15252/emmm.202115415

Targeting of GSDMD sensitizes HCC to anti-PD-1 by activating cGAS pathway and downregulating PD-L1 expression – Tingting Lv, Xiaofeng Xiong, Wei Yan, Mei Liu, Hongwei Xu and Qin He. https://jitc.bmj.com/content/10/6/e004763


Ferroptosis


Cancer cells dying from ferroptosis impede dendritic cell-mediated anti-tumor immunity – Bartosz Wiernicki, Sophia Maschalidi, Jonathan Pinney, Sandy Adjemian, Tom Vanden Berghe, Kodi S. Ravichandran and Peter Vandenabeele. https://www.nature.com/articles/s41467-022-31218-2

Ferroptosis mediates selective motor neuron death in amyotrophic lateral sclerosis – Taide Wang, Doris Tomas, Nirma D. Perera, Brittany Cuic, Sophia Luikinga, Aida Viden, Samantha K. Barton, Catriona A. McLean, André L. Samson, Adam Southon, Ashley I. Bush, James M. Murphy and Bradley J. Turner. https://www.nature.com/articles/s41418-021-00910-z

A ferroptosis defense mechanism mediated by glycerol-3-phosphate dehydrogenase 2 in mitochondria – Shiqi Wu, Chao Mao, Lavanya Kondiparthi, Masha V. Poyurovsky, Kellen Olszewski and Boyi Gan. https://www.pnas.org/doi/10.1073/pnas.2121987119


Miscellanous


Optogenetic activators of apoptosis, necroptosis, and pyroptosis – Kateryna Shkarina, Eva Hasel de Carvalho, José Carlos Santos, Saray Ramos, Maria Leptin, Petr Broz. https://rupress.org/jcb/article/221/6/e202109038/213145

DRP1 levels determine the apoptotic threshold during embryonic differentiation through a mitophagy-dependent mechanism – Barbara Pernaute, Salvador Pérez-Montero, Juan Miguel Sánchez Nieto, Aida Di Gregorio, Ana Lima, Katerina Lawlor, Sarah Bowling, Gianmaria Liccardi, Alejandra Tomás, Pascal Meier, Hiromi Sesaki, Guy A. Rutter, Ivana Barbaric, Tristan A. Rodríguez. https://www.cell.com/developmental-cell/fulltext/S1534-5807(22)00306-9

A signature for pan-cancer prognosis based on neutrophil extracellular traps – Yi Zhang, Liping Guo, Qichen Dai, Bingqing Shang, Ting Xiao, Xuebing Di, Kaitai Zhang, Lin Feng, Jianzhong Shou and Yipeng Wang. https://jitc.bmj.com/content/10/6/e004210

TIR domains of plant immune receptors are 2′,3′-cAMP/cGMP synthetases mediating cell death – Dongli Yu, Wen Song, Eddie Yong Jun Tan, Li Liu, Yu Cao, Jan Jirschitzka, Ertong Li, Elke Logemann, Chenrui Xu, Shijia Huang, Aolin Jia, Xiaoyu Chang, Zhifu Han, Bin Wu, Paul Schulze-Lefert, Jijie Chai. https://www.cell.com/cell/fulltext/S0092-8674(22)00530-X


Reviews


What can we learn from mice lacking pro-survival BCL-2 proteins to advance BH3 mimetic drugs for cancer therapy? – Kerstin Brinkmann, Ashley P. Ng, Carolyn A. de Graaf and Andreas Strasser. https://www.nature.com/articles/s41418-022-00987-0

Paradoxical roles of caspase-3 in regulating cell survival, proliferation, and tumorigenesis – Ebrahim Eskandari, Connie J. Eaves. https://rupress.org/jcb/article/221/6/e202201159/213213

Structural Details of BH3 Motifs and BH3-Mediated Interactions: an Updated Perspective – Valentina Sora and Elena Papaleo. https://www.frontiersin.org/articles/10.3389/fmolb.2022.864874/full

Ferroptosis at the intersection of lipid metabolism and cellular signaling – Deguang Liang, Alexander M. Minikes, Xuejun Jiang. https://www.cell.com/molecular-cell/fulltext/S1097-2765(22)00260-X

Cell Death-Related Ubiquitin Modifications in Inflammatory Syndromes: From Mice to Men – Nieves Peltzer and Alessandro Annibaldi. https://www.mdpi.com/2227-9059/10/6/1436


Comments


Killing cells using light (activated) sabers – Stephen W.G. Tait. https://rupress.org/jcb/article/221/6/e202205018/213218

BAX and BAK dynamics control mitochondrial DNA release during apoptosis – Takahiro Yamazaki and Lorenzo Galluzzi. https://www.nature.com/articles/s41418-022-00985-2

ApoList – May 2022


Bcl-2 family proteins


Mitochondrial dynamics regulate genome stability via control of caspase-dependent DNA damage – Kai Cao, Joel S. Riley, Rosalie Heilig, Alfredo E. Montes-Gómez, Esmee Vringer, Kevin Berthenet, Catherine Cloix, Yassmin Elmasry, David G. Spiller, Gabriel Ichim, Kirsteen J. Campbell, Andrew P. Gilmore, Stephen W.G. Tait. https://www.cell.com/developmental-cell/fulltext/S1534-5807(22)00229-5

Disruption of mitochondrial quality control genes promotes caspase-resistant cell survival following apoptotic stimuli – Yulia Kushnareva, Vivian Moraes, Julian Suess, Bjoern Peters, Donald D. Newmeyer, Tomomi Kuwana. https://www.jbc.org/article/S0021-9258(22)00275-7/fulltext

Bcl-xL enforces a slow-cycling state necessary for survival in the nutrient-deprived microenvironment of pancreatic cancer – Yogev Sela, Jinyang Li, Shivahamy Maheswaran, Robert J Norgard, Salina Yuan, Maimon E Hubbi, Miriam Doepner, Jimmy P Xu, Elaine S Ho, Clementina Mesaros, Colin Sheehan, Grace Croley, Alexander Muir, Ian A Blair, Ophir Shalem, Chi V Dang, Ben Z Stanger. https://aacrjournals.org/cancerres/article-abstract/doi/10.1158/0008-5472.CAN-22-0431/682341

Acetic acid triggers cytochrome c release in yeast heterologously expressing human Bax – Joana P. Guedes, Vitória Baptista, Cátia Santos-Pereira, Maria João Sousa, Stéphen Manon, Susana R. Chaves, Manuela Côrte-Real. https://link.springer.com/article/10.1007/s10495-022-01717-0

Increased apoptotic sensitivity of glioblastoma enables therapeutic targeting by BH3-mimetics – Anna L. Koessinger, Catherine Cloix, Dominik Koessinger, Dieter Henrik Heiland, Florian J. Bock, Karen Strathdee, Kevin Kinch, Laura Martínez-Escardó, Nikki R. Paul, Colin Nixon, Gaurav Malviya, Mark R. Jackson, Kirsteen J. Campbell, Katrina Stevenson, Sandeep Davis, Yassmin Elmasry, Asma Ahmed, Jim O’Prey, Gabriel Ichim, Oliver Schnell, William Stewart, Karen Blyth, Kevin M. Ryan, Anthony J. Chalmers, Jim C. Norman and Stephen W. G. Tait. https://www.nature.com/articles/s41418-022-01001-3


Death receptors


Tankyrase-mediated ADP-ribosylation is a regulator of TNF-induced death – Lin Liu, Jarrod J. Sandow, Deena M. Leslie Pedrioli, Andre L. Samson, Natasha Silke, Tobias Kratina, Rebecca L. Ambrose, Marcel Doerflinger, Zhaoqing Hu, Emma Morrish, Diep Chau, Andrew J. Kueh, Cheree Fitzibbon, Marc Pellegrini, Jaclyn S. Pearson, Michael O. Hottiger, Andrew I. Webb, Najoua Lalaoui, John Silke. https://www.science.org/doi/full/10.1126/sciadv.abh2332

Human B Cells Mediate Innate Anti-Cancer Cytotoxicity Through Concurrent Engagement of Multiple TNF Superfamily Ligands – Bratislav M Janjic, Aditi Kulkarni, Robert L Ferris, Lazar Vujanovic, Nikola L Vujanovic. https://www.frontiersin.org/articles/10.3389/fimmu.2022.837842/full

FasL microgels induce immune acceptance of islet allografts in nonhuman primates – Ji Lei, María M. Coronel, Esma S. Yolcu, Hongping Deng, Orlando Grimany-Nuno, Michael D. Hunckler, Vahap Ulker, Zhihong Yang, Kang M. Lee, Alexander Zhang, Hao Luo, Cole W. Peters, Zhongliang Zou, Tao Chen, Zhenjuan Wang, Colleen S. McCoy, Ivy A. Rosales, James F. Markmann, Haval Shirwan, Andrés J. García. https://www.science.org/doi/full/10.1126/sciadv.abm9881


Caspases and IAPs


Pathogen hijacks programmed cell death signaling by arginine ADPR-deacylization of caspases – Ting Peng, Xinyuan Tao, Zhujun Xia, Shufan Hu, Juan Xue, Qiuyu Zhu, Xing Pan, Qiang Zhang, Shan Li. https://www.cell.com/molecular-cell/fulltext/S1097-2765(22)00219-2

Caspase cleavage and nuclear retention of the energy sensor AMPK-α1 during apoptosis – Anees Rahman Cheratta, Faisal Thayyullathil, Simon A. Hawley, Fiona A. Ross, Abdelmajdid Atrih, Douglas J. Lamont, Siraj Pallichankandy, Karthikeyan Subburayan, Ameer Alakkal, Rachid Rezgui, Alex Gray, D. Grahame Hardie, Sehamuddin Galadari. https://www.cell.com/cell-reports/fulltext/S2211-1247(22)00525-3

Caspase-9b drives cellular transformation, lung inflammation, and lung tumorigenesis – Minjung Kim, Ngoc T Vu, Xue Wang, Gamze B Bulut, Min-Hsuan Wang, Cora Uram-Tuculescu, Raghavendra Pillappa, Sungjune Kim, Charles E Chalfant.. https://aacrjournals.org/mcr/article/doi/10.1158/1541-7786.MCR-21-0905/696288/

XIAP promotes melanoma growth by inducing tumour neutrophil infiltration – Mila Daoud, Pia Nora Broxtermann, Fabian Schorn, J Paul Werthenbach, Jens Michael Seeger, Lars M Schiffmann, Kerstin Brinkmann, Domagoj Vucic, Thomas Tüting, Cornelia Mauch, Dagmar Kulms, Paola Zigrino, Hamid Kashkar. https://www.embopress.org/doi/full/10.15252/embr.202153608


Necroptosis


Osmotic stress activates RIPK3/MLKL-mediated necroptosis by increasing cytosolic pH through a plasma membrane Na+/H+ exchanger – Wenbin Zhang, Weiliang Fan, Jia Guo, Xiaodong Wang. https://www.science.org/doi/abs/10.1126/scisignal.abn5881

Z-DNA binding protein 1 promotes heatstroke-induced cell death – Fangfang Yuan, Jizhen Cai, Jianfeng Wu, Yiting Tang, Kai Zhao, Fang Liang, Fanglin Li, Xinyu Yang, Zhihui He, Timothy R. Billiar, Haichao Wang, Lei Su, Ben Lu. https://www.science.org/doi/abs/10.1126/science.abg5251

ADAR1 masks the cancer immunotherapeutic promise of ZBP1-driven necroptosis – Ting Zhang, Chaoran Yin, Aleksandr Fedorov, Liangjun Qiao, Hongliang Bao, Nazar Beknazarov, Shiyu Wang, Avishekh Gautam, Riley M. Williams, Jeremy Chase Crawford, Suraj Peri, Vasily Studitsky, Amer A. Beg, Paul G. Thomas, Carl Walkley, Yan Xu, Maria Poptsova, Alan Herbert and Siddharth Balachandran. https://www.nature.com/articles/s41586-022-04753-7


Pyroptosis


GSDMEa-mediated pyroptosis is bi-directionally regulated by caspase and required for effective bacterial clearance in teleost – Hang Xu, Shuai Jiang, Chao Yu, Zihao Yuan and Li Sun. https://www.nature.com/articles/s41419-022-04896-5


Efferocytosis, entosis etc


Targeting SLC7A11 improves efferocytosis by dendritic cells and wound healing in diabetes – Sophia Maschalidi, Parul Mehrotra, Burcu N. Keçeli, Hannah K. L. De Cleene, Kim Lecomte, Renée Van der Cruyssen, Pauline Janssen, Jonathan Pinney, Geert van Loo, Dirk Elewaut, Ann Massie, Esther Hoste and Kodi S. Ravichandran. https://www.nature.com/articles/s41586-022-04754-6

Cooperative epithelial phagocytosis enables error correction in the early embryo – Esteban Hoijman, Hanna-Maria Häkkinen, Queralt Tolosa-Ramon, Senda Jiménez-Delgado, Chris Wyatt, Marta Miret-Cuesta, Manuel Irimia, Andrew Callan-Jones, Stefan Wieser and Verena Ruprecht. https://www.nature.com/articles/s41586-021-03200-3

Neuronal apoptosis drives remodeling states of microglia and shifts in survival pathway dependence -Sarah Rose Anderson, Jacqueline M Roberts, Nathaniel Ghena, Emmalyn A Irvin, Joon Schwakopf, Isabelle B Cooperstein, Alejandra Bosco, Monica L Vetter. https://elifesciences.org/articles/76564

Toll-9 interacts with Toll-1 to mediate a feedback loop during apoptosis-induced proliferation in Drosophila – Alicia Shields, Alla Amcheslavsky, Elizabeth Brown, Tom V. Lee, Yingchao Nie, Takahiro Tanji, Y. Tony Ip, Andreas Bergmann. https://www.cell.com/cell-reports/fulltext/S2211-1247(22)00588-5

Extracellular ATP facilitates cell extrusion from epithelial layers mediated by cell competition or apoptosis – Yusuke Mori, Naoka Shiratsuchi, Nanami Sato, Azusa Chaya, Nobuyuki Tanimura, Susumu Ishikawa, Mugihiko Kato, Ikumi Kameda, Shunsuke Kon, Yukinari Haraoka, Tohru Ishitani, Yasuyuki Fujita. https://www.cell.com/current-biology/fulltext/S0960-9822(22)00491-2


Miscellanous


Erebosis, a new cell death mechanism during homeostatic turnover of gut enterocytes – Hanna M. Ciesielski, Hiroshi Nishida, Tomomi Takano, Aya Fukuhara, Tetsuhisa Otani, Yuko Ikegawa, Morihiro Okada, Takashi Nishimura, Mikio Furuse, Sa Kan Yoo. https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3001586

Robust transcriptional indicators of immune cell death revealed by spatio-temporal transcriptome analyses – Jose Salguero-Linares, Irene Serrano, Nerea Ruiz-Solani, Marta Salas-Gómez, Ujjal Jyoti Phukan, Victor Manuel González, Martí Bernardo-Faura, Marc Valls, David Rengel, Nuria S. Coll. https://www.cell.com/molecular-plant/fulltext/S1674-2052(22)00147-2

Fatty acid oxidation protects cancer cells from apoptosis by increasing mitochondrial membrane lipids – Yi-Jia Li, Johannes Francois Fahrmann, Maryam Aftabizadeh, Qianqian Zhao, Satyendra C. Tripathi, Chunyan Zhang, Yuan Yuan, David Ann, Samir Hanash, Hua Yu. https://www.cell.com/cell-reports/fulltext/S2211-1247(22)00645-3

PI(18:1/18:1) is a SCD1-derived lipokine that limits stress signaling – Maria Thürmer, André Gollowitzer, Helmut Pein, Konstantin Neukirch, Elif Gelmez, Lorenz Waltl, Natalie Wielsch, René Winkler, Konstantin Löser, Julia Grander, Madlen Hotze, Sönke Harder, Annika Döding, Martina Meßner, Fabiana Troisi, Maximilian Ardelt, Hartmut Schlüter, Johanna Pachmayr, Óscar Gutiérrez-Gutiérrez, Karl Lenhard Rudolph, Kathrin Thedieck, Ulrike Schulze-Späte, Cristina González-Estévez, Christian Kosan, Aleš Svatoš, Marcel Kwiatkowski and Andreas Koeberle. https://www.nature.com/articles/s41467-022-30374-9

Flow cytometric single cell-based assay to simultaneously detect cell death, cell cycling, DNA content and cell senescence – Elizabeth Lieschke, Zilu Wang, Catherine Chang, Clare E. Weeden, Gemma L. Kelly and Andreas Strasser. https://www.nature.com/articles/s41418-022-00964-7


Reviews


Adapted to Survive: Targeting Cancer Cells with BH3 Mimetics – Joan Montero and Rizwan Haq. https://aacrjournals.org/cancerdiscovery/article/12/5/1217/694529

Protein–protein and protein–lipid interactions of pore-forming BCL-2 family proteins in apoptosis initiation – Giridhar Sekar, Adedolapo Ojoawo, Tudor Moldoveanu. https://portlandpress.com/biochemsoctrans/article-abstract/doi/10.1042/BST20220323/231272

Immunogenic cell stress and injury versus immunogenic cell death: implications for improving cancer treatment with immune checkpoint blockade – Ganapathy Sriram, Tiffany R Emmons, Lauren E Milling, Darrell J Irvine, Michael B Yaffe. https://www.tandfonline.com/doi/full/10.1080/23723556.2022.2039038

Targeting the apoptosis pathway to treat tumours of the paediatric nervous system – Marie-Claire Fitzgerald, Philip J. O’Halloran, Niamh M. C. Connolly and Brona M. Murphy. https://www.nature.com/articles/s41419-022-04900-y

Of the many cellular responses activated by TP53, which ones are critical for tumour suppression? – Annabella F. Thomas, Gemma L. Kelly and Andreas Strasser. https://www.nature.com/articles/s41418-022-00996-z

No longer married to inflammasome signaling: the diverse interacting pathways leading to pyroptotic cell death – Ashley Weir, James E. Vince. https://portlandpress.com/biochemj/article/479/10/1083/231341

Deubiquitinases in cell death and inflammation – Kim Newton, Alexander D. Gitlin. https://portlandpress.com/biochemj/article/479/10/1103/231340

RIP1 post-translational modifications – Eugene Varfolomeev, Domagoj Vucic. https://portlandpress.com/biochemj/article-abstract/479/9/929/231273


Comments


[AMPK] Cleaved to keep dying cells alive – Leslie K. Ferrarelli. https://www.science.org/doi/full/10.1126/scisignal.abq8516

A novel crosstalk between autophagosomes and phagosomes that facilitates the clearance of apoptotic cells – Zheng Zhou and Omar Peña-Ramos. https://www.tandfonline.com/doi/abs/10.1080/15548627.2022.2080384

Cuproptosis: Cellular and molecular mechanisms underlying copper-induced cell death – Paul A. Cobine, Donita C. Brady. https://www.cell.com/molecular-cell/fulltext/S1097-2765(22)00435-X

IFNγ regulates ferroptosis with fatty acids – Zhe Wang. https://www.nature.com/articles/s41556-022-00921-z

ATP and ROS signal cell extrusion – Paulina Strzyz. https://www.nature.com/articles/s41580-022-00487-6


European Workshop on Cell Death in Fiuggi (near Roma) June 22: registration and poster submission still open if you can pay registration before June 10th. See you there!

https://www.ewcd.eu/

ECDO 2022 in Bonn, september. https://www.ecdo.eu/

ApoList – April 2022


Bcl-2 family proteins


Some mice lacking intrinsic, as well as death  receptor induced apoptosis and necroptosis, can survive to adulthood – Francine F. S. Ke,  Kerstin Brinkmann, Anne K. Voss and Andreas Strasser. https://www.nature.com/articles/s41419-022-04731-x

Augmenting NK cell-based immunotherapy by targeting mitochondrial apoptosis – Rongqing Pan, Jeremy Ryan, Deng Pan, Kai W. Wucherpfennig, Anthony Letai. https://www.cell.com/cell/fulltext/S0092-8674(22)00340-3

Single-cell transcriptomics identifies Mcl-1 as a target for senolytic therapy in cancer – Martina Troiani, Manuel Colucci, Mariantonietta D’Ambrosio, Ilaria Guccini, Emiliano Pasquini, Angelica Varesi, Aurora Valdata, Simone Mosole, Ajinkya Revandkar, Giuseppe Attanasio, Andrea Rinaldi, Anna Rinaldi, Marco Bolis, Pietro Cippà and Andrea Alimonti. https://www.nature.com/articles/s41467-022-29824-1

Efficacy and specificity of inhibitors of BCL-2 family protein interactions assessed by affinity measurements in live cells – Elizabeth J. Osterlund, Nehad Hirmiz, James M. Pemberton, Adrien Nougarède, Qian Liu, Brian Leber, Qiyin Fang, David W. Andrews. https://www.science.org/doi/full/10.1126/sciadv.abm7375

MEK and MCL-1 sequential inhibition synergize to enhance rhabdomyosarcoma treatment – Clara Alcon, Fernando Martín, Estela Prada, Jaume Mora, Aroa Soriano, Gabriela Guillén, Soledad Gallego, Josep Roma, Josep Samitier, Alberto Villanueva and Joan Montero. https://www.nature.com/articles/s41420-022-00959-w

DRP1 interacts directly with BAX to induce its activation and apoptosis – Andreas Jenner, Aida Peña-Blanco, Raquel Salvador-Gallego, Begoña Ugarte-Uribe, Cristiana Zollo, Tariq Ganief, Jan Bierlmeier, Markus Mund, Jason E Lee, Jonas Ries, Dirk Schwarzer, Boris Macek, Ana J Garcia-Saez. https://www.embopress.org/doi/full/10.15252/embj.2021108587


Death receptors


TNF-α sculpts a maturation process in vivo by pruning tolerogenic dendritic cells – Courtney A. Iberg, Jessica Bourque, Ian Fallahee, Sungho Son, Daniel Hawiger. https://www.cell.com/cell-reports/fulltext/S2211-1247(22)00409-0

CDK4/6 Inhibition Suppresses p73 Phosphorylation and Activates DR5 to Potentiate Chemotherapy and Immune Checkpoint Blockade – Jingshan Tong, Xiao Tan, Xiangping Song, Man Gao, Denise Risnik, Suisui Hao, Kaylee Ermine, Peng Wang, Hua Li, Yi Huang, Jian Yu, Lin Zhang. https://aacrjournals.org/cancerres/article-abstract/82/7/1340/694058

Inflammation induces pro-NETotic neutrophils via TNFR2 signaling – Friederike Neuenfeldt, Jan Christoph Schumacher, Ricardo Grieshaber-Bouyer, Jüri Habicht, Jutta Schröder-Braunstein, Annika Gauss, Uta Merle, Beate Niesler, Niko Heineken, Alexander Dalpke, Matthias M. Gaida, Thomas Giese, Stefan Meuer, Yvonne Samstag, Guido Wabnitz. https://www.cell.com/cell-reports/fulltext/S2211-1247(22)00471-5?dgcid=raven_jbs_etoc_email


Caspases


Non-apoptotic activation of Drosophila caspase-2/9 modulates JNK signaling, the tumor microenvironment, and growth of wound-like tumors – Derek Cui Xu, Li Wang, Kenneth M. Yamada, Luis Alberto Baena-Lopez. https://www.cell.com/cell-reports/fulltext/S2211-1247(22)00479-X

The caspase-2 substrate p54nrb exhibits a multifaceted role in tumor cell death susceptibility via gene regulatory functions – Madeleine Eichler, Ute Distler, Usman Nasrullah, Aswini Krishnan, Manuel Kaulich, Koraljka Husnjak, Wolfgang Eberhardt, Krishnaraj Rajalingam, Stefan Tenzer, Josef Pfeilschifter and Gergely Imre. https://www.nature.com/articles/s41419-022-04829-2


Necroptosis


Mosaic composition of RIP1–RIP3 signalling hub and its role in regulating cell death – Xin Chen, Rongfeng Zhu, Jinjin Zhong, Yongfa Ying, Wenxin Wang, Yating Cao, Hanyi Cai, Xiang Li, Jianwei Shuai and Jiahuai Han. https://www.nature.com/articles/s41556-022-00854-7

The interferon-stimulated gene RIPK1 regulates cancer cell intrinsic and extrinsic resistance to immune checkpoint blockade – Lisa Cucolo, Qingzhou Chen, Jingya Qiu, Yongjun Yu, Max Klapholz, Krista A. Budinich, Zhaojun Zhang, Yue Shao, Igor E. Brodsky, Martha S. Jordan, D. Gary Gilliland, Nancy R. Zhang, Junwei Shi, Andy J. Minn. https://www.cell.com/immunity/fulltext/S1074-7613(22)00130-3

CAMK2/CaMKII activates MLKL in short-term starvation to facilitate autophagic flux – Qionghui Zhan, Jaepyo Jeon, Ying Li, Yu Huang, Jian Xiong, Qiaochu Wang, Tian-Le Xu, Yong Li, Fu-Hai Ji, Guangwei Du and Michael X Zhu. https://www.tandfonline.com/doi/full/10.1080/15548627.2021.1954348

MLKL deficiency in BrafV600EPten−/− melanoma model results in a modest delay of nevi development and reduced lymph node dissemination in male mice – Sofie Martens, Nozomi Takahashi, Gillian Blancke, Niels Vandamme, Hanne Verschuere, Tatyana Divert, Marnik Vuylsteke, Geert Berx and Peter Vandenabeele. https://www.nature.com/articles/s41419-022-04819-4


Pyroptosis


Activation and manipulation of inflammasomes and pyroptosis during bacterial infections – Elliott M. Bernard, Petr Broz. https://portlandpress.com/biochemj/article-abstract/479/7/867/231175


Ferroptosis


CD8+ T cells and fatty acids orchestrate tumor ferroptosis and immunity via ACSL4 – Peng Liao, Weimin Wang, Weichao Wang, Ilona Kryczek, Xiong Li, Yingjie Bian, Amanda Sell, Shuang Wei, Sara Grove, Jeffrey K. Johnson, Paul D. Kennedy, Miguel Gijón, Yatrik M. Shah, Weiping Zou. https://www.cell.com/cancer-cell/fulltext/S1535-6108(22)00036-8

Ferroptosis in plants: regulation of lipid peroxidation and redox status – Ayelén Mariana Distéfano, Gabriel Alejandro López, Victoria Bauer, Eduardo Zabaleta, Gabriela Carolina Pagnussat. https://portlandpress.com/biochemj/article-abstract/479/7/857/231174


Efferocytosis, entosis etc


Stem cell conversion to the cardiac lineage requires nucleotide signalling from apoptosing cells – Loic Fort, Vivian Gama and Ian G. Macara. https://www.nature.com/articles/s41556-022-00888-x

Macrophages use apoptotic cell-derived methionine and DNMT3A during efferocytosis to promote tissue resolution – Patrick B. Ampomah, Bishuang Cai, Santosh R. Sukka, Brennan D. Gerlach, Arif Yurdagul Jr, Xiaobo Wang, George Kuriakose, Lancia N. F. Darville, Yan Sun, Simone Sidoli, John M. Koomen, Alan R. Tall and Ira Tabas. https://www.nature.com/articles/s42255-022-00551-7


Miscellanous


Early SRC activation skews cell fate from apoptosis to senescence – Carlos Anerillas, Allison B. Herman, Martina Rossi, Rachel Munk, Elin Lehrmann, Jennifer L. Martindale, Chang-Yi Cui, Kotb Abdelmohsen, Supriyo De, Myriam Gorospe. https://www.science.org/doi/full/10.1126/sciadv.abm0756

NAMPT-dependent NAD+ salvage is crucial for the decision between apoptotic and necrotic cell death under oxidative stress – Takuto Nishida, Isao Naguro and Hidenori Ichijo. https://www.nature.com/articles/s41420-022-01007-3

Yeast cell death pathway requiring AP-3 vesicle trafficking leads to vacuole/lysosome membrane permeabilization -Zachary D. Stolp, Madhura Kulkarni, Yining Liu, Chengzhang Zhu, Alizay Jalisi, Si Lin, Arturo Casadevall, Kyle W. Cunningham, Fernando J. Pineda, Xinchen Teng, J. Marie Hardwick. https://www.cell.com/cell-reports/fulltext/S2211-1247(22)00399-0


Reviews / comments


Immunogenic cell stress and death – Guido Kroemer, Claudia Galassi, Laurence Zitvogel and Lorenzo Galluzzi. https://www.nature.com/articles/s41590-022-01132-2

RIPK1 and RIPK3 form mosaic necrosomes – Weiwei Qi and Junying Yuan. https://www.nature.com/articles/s41556-022-00879-y

RIP(K)ing away immunotherapy resistance – Mira A. Patel, Sohail F. Tavazoie. https://www.cell.com/immunity/fulltext/S1074-7613(22)00133-9

Dying cell-derived SAM switches off inflammation – Roel P. H. De Maeyer and Derek W. Gilroy. https://www.nature.com/articles/s42255-022-00556-2


EMBO Journal cover – Jenner et al

https://www.embopress.org/cms/asset/9ba6ed7a-df0b-4d7c-9afb-268eb7547e11/embj.v41.8.cover.jpg

ApoList – March 2022


Bcl-2 family proteins


The interplay between BAX and BAK tunes apoptotic pore growth to control mitochondrial-DNA-mediated inflammation – Katia Cosentino, Vanessa Hertlein, Andreas Jenner, Timo Dellmann, Milos Gojkovic, Aida Peña-Blanco, Shashank Dadsena, Noel Wajngarten, John S.H. Danial, Jervis Vermal Thevathasan, Markus Mund, Jonas Ries, Ana J. Garcia-Saez. https://www.cell.com/molecular-cell/fulltext/S1097-2765(22)00008-9

Co-targeting of BAX and BCL-XL proteins broadly overcomes resistance to apoptosis in cancer – Andrea Lopez, Denis E. Reyna, Nadege Gitego, Felix Kopp, Hua Zhou, Miguel A. Miranda-Roman, Lars Ulrik Nordstrøm, Swathi-Rao Narayanagari, Ping Chi, Eduardo Vilar, Aristotelis Tsirigos and Evripidis Gavathiotis. https://www.nature.com/articles/s41467-022-28741-7

Pharmacologic Reduction of Mitochondrial Iron Triggers a Noncanonical BAX/BAK-Dependent Cell Death – Sylvain Garciaz, Andrew A. Guirguis, Sebastian Müller, Fiona C. Brown, Yih-Chih Chan, Ali Motazedian, Caitlin L. Rowe, James A. Kuzich, Kah Lok Chan, Kevin Tran, Lorey Smith, Laura MacPherson, Brian Liddicoat, Enid Y.N. Lam, Tatiana Cañeque, Marian L. Burr, Véronique Litalien, Giovanna Pomilio, Mathilde Poplineau, Estelle Duprez, Sarah-Jane Dawson, Georg Ramm, Andrew G. Cox, Kristin K. Brown, David C.S. Huang, Andrew H. Wei, Kate McArthur, Raphaël Rodriguez, Mark A. Dawson. https://aacrjournals.org/cancerdiscovery/article/12/3/774/681925

Potent, p53-independent induction of NOXA sensitizes MLL-rearranged B-cell acute lymphoblastic leukemia cells to venetoclax – Klaudyna Fidyt, Agata Pastorczak, Julia Cyran, Nicholas T. Crump, Agnieszka Goral, Joanna Madzio, Angelika Muchowicz, Martyna Poprzeczko, Krzysztof Domka, Lukasz Komorowski, Magdalena Winiarska, Joe R. Harman, Karolina Siudakowska, Agnieszka Graczyk-Jarzynka, Elzbieta Patkowska, Ewa Lech-Maranda, Wojciech Mlynarski, Jakub Golab, Thomas A. Milne and Malgorzata Firczuk. https://www.nature.com/articles/s41388-022-02196-y

Overcoming acquired resistance to third-generation EGFR inhibitors by targeting activation of intrinsic apoptotic pathway through Mcl-1 inhibition, Bax activation, or both – Guangzhi Ma, Yunfu Deng, Luxi Qian, Karin A. Vallega, Guojing Zhang, Xingming Deng, Taofeek K. Owonikoko, Suresh S. Ramalingam, Douglas D. Fang, Yifan Zhai and Shi-Yong Sun. https://www.nature.com/articles/s41388-022-02200-5

Targeting mitochondrial respiration and the BCL2 family in high‐grade MYC‐associated B‐cell lymphoma – Giulio Donati, Micol Ravà, Marco Filipuzzi, Paola Nicoli, Laura Cassina, Alessandro Verrecchia, Mirko Doni, Simona Rodighiero, Federica Parodi, Alessandra Boletta, Christopher P. Vellano, Joseph R. Marszalek, Giulio F. Draetta, Bruno Amati. https://febs.onlinelibrary.wiley.com/doi/full/10.1002/1878-0261.13115

Mcl‐1 and Bcl‐xL levels predict responsiveness to dual MEK/Bcl‐2 inhibition in B‐cell malignancies – Katrine Melvold, Mariaserena Giliberto, Linda Karlsen, Pilar Ayuda-Durán, Robert Hanes, Toril Holien, Jorrit Enserink, Jennifer R. Brown, Geir E. Tjønnfjord, Kjetil Taskén, Sigrid S. Skånland. https://febs.onlinelibrary.wiley.com/doi/full/10.1002/1878-0261.13153

CRISPR activation screen identifies BCL-2 proteins and B3GNT2 as drivers of cancer resistance to T cell-mediated cytotoxicity – Julia Joung, Paul C. Kirchgatterer, Ankita Singh, Jang H. Cho, Suchita P. Nety, Rebecca C. Larson, Rhiannon K. Macrae, Rebecca Deasy, Yuen-Yi Tseng, Marcela V. Maus and Feng Zhang. https://www.nature.com/articles/s41467-022-29205-8


Death receptors


Potent pro-apoptotic combination therapy is highly effective in a broad range of cancers – Antonella Montinaro, Itziar Areso Zubiaur, Julia Saggau, Anna-Laura Kretz, Rute M. M. Ferreira, Omar Hassan, Ella Kitzig, Ines Müller, Mona A. El-Bahrawy, Silvia von Karstedt, Dagmar Kulms, Gianmaria Liccardi, Johannes Lemke and Henning Walczak. https://www.nature.com/articles/s41418-021-00869-x

Bacterial inhibition of Fas-mediated killing promotes neuroinvasion and persistence – Claire Maudet, Marouane Kheloufi, Sylvain Levallois, Julien Gaillard, Lei Huang, Charlotte Gaultier, Yu-Huan Tsai, Olivier Disson and Marc Lecuit. https://www.nature.com/articles/s41586-022-04505-7

Interferon-γ primes macrophages for pathogen ligand-induced killing via a caspase-8 and mitochondrial cell death pathway – Daniel S. Simpson, Jiyi Pang, Ashley Weir, Isabella Y. Kong, Melanie Fritsch, Maryam Rashidi, James P. Cooney, Kathryn C. Davidson, Mary Speir, Tirta M. Djajawi, Sebastian Hughes, Liana Mackiewicz, Merle Dayton, Holly Anderton, Marcel Doerflinger, Yexuan Deng, Allan Shuai Huang, Stephanie A. Conos, Hazel Tye, Seong H. Chow, Arfatur Rahman, Raymond S. Norton, Thomas Naderer, Sandra E. Nicholson, Gaetan Burgio, Si Ming Man, Joanna R. Groom, Marco J. Herold, Edwin D. Hawkins, Kate E. Lawlor, Andreas Strasser, John Silke, Marc Pellegrini, Hamid Kashkar, Rebecca Feltham, James E. Vince. https://www.cell.com/immunity/fulltext/S1074-7613(22)00032-2

Engineering adoptive T cell therapy to co-opt Fas ligand-mediated death signaling in ovarian cancer enhances therapeutic efficacy – Kristin G Anderson, Shannon K Oda, Breanna M Bates, Madison G Burnett, Magdalia Rodgers Suarez, Susan L Ruskin and Philip D Greenberg. https://jitc.bmj.com/content/10/3/e003959

Cancer cell-intrinsic resistance to BiTE therapy is mediated by loss of CD58 costimulation and modulation of the extrinsic apoptotic pathway – Ye Shen, Jason S Eng, Flordeliza Fajardo, Lingming Liang, Cong Li, Patrick Collins, Donato Tedesco and Olivier Nolan-Stevaux.  https://jitc.bmj.com/content/10/3/e004348


Caspases / IAPs


Caspase-8 has dual roles in regulatory T cell homeostasis balancing immunity to infection and collateral inflammatory damage – Charis E. Teh, Simon P. Preston, Alissa K. Robbins, Michael D. Stutz, James Cooney, Michelle P. Clark, Antonia N. Policheni, Cody C. Allison, Liana Mackiewicz, Philip Arandjelovic, Gregor Ebert, Marcel Doerflinger, Tania Tan, Lucille C. Rankin, Peggy P. Teh, Gabrielle T. Belz, Axel Kallies, Andreas Strasser, Marc Pellegrini, Daniel H. D. Gray. https://www.science.org/doi/abs/10.1126/sciimmunol.abn8041

Survivin is essential for thermogenic program and metabolic homeostasis in mice – Miriayi Alimujiang, Jingjing Sun, Shuqing Chen, Ningning Bai, Shuqin Chen, Fan Hu, Jingyuan Ma, Yuejie Xu, Jun Xu, Xiaojing Ma, Ying Yang. https://www.sciencedirect.com/science/article/pii/S2212877822000151

Therapeutic potential of Nlrp1 inflammasome, Caspase-1, or Caspase-6 against Alzheimer disease cognitive impairment – Joseph Flores, Anastasia Noël, Marie-Lyne Fillion and Andréa C. LeBlanc. https://www.nature.com/articles/s41418-021-00881-1


Pyroptosis


Fracture healing is delayed in the absence of gasdermin-interleukin-1 signaling – Kai Sun, Chun Wang, Jianqiu Xiao, Michael D Brodt, Luorongxin Yuan, Tong Yang, Yael Alippe, Huimin Hu, Dingjun Hao, Yousef Abu-Amer, Matthew J Silva, Jie Shen, Gabriel Mbalaviele . https://elifesciences.org/articles/75753


Ferroptosis


Kynurenine importation by SLC7A11 propagates anti-ferroptotic signaling – Alessandra Fiore, Leonie Zeitler, Marion Russier, Annette Groß, Maria-Kathrin Hiller, Joanne L. Parker, Luca Stier, Thomas Köcher, Simon Newstead, Peter J. Murray. https://www.cell.com/molecular-cell/fulltext/S1097-2765(22)00112-5

Ferroptosis induces membrane blebbing in placental trophoblasts – Kazuhiro Kajiwara, Ofer Beharier, Choon-Peng Chng, Julie P. Goff, Yingshi Ouyang, laudette M. St Croix, Changjin Huang, Valerian E. Kagan, K. Jimmy Hsia, Yoel Sadovsky. https://journals.biologists.com/jcs/article/135/5/jcs255737/224124/


Efferocytosis, immunogenicity


Live cell tracking of macrophage efferocytosis during Drosophila embryo development in vivo – Michael H. Raymond, Andrew J. Davidson, Yi Shen, Daniel R. Tudor, Christopher D. Lucas, Sho Morioka, Justin S. A. Perry, Julia Krapivkina, David Perrais, Linus J. Schumacher, Robert E. Campbell, Will Wood, Kodi S. Ravichandran. https://www.science.org/doi/abs/10.1126/science.abl4430

Cell death-induced immunogenicity enhances chemoimmunotherapeutic response by converting immune-excluded into T-cell inflamed bladder tumors – Fotis Nikolos, Kazukuni Hayashi, Xen Ping Hoi, Mark Ellie Alonzo, Qianxing Mo, Armine Kasabyan, Hideki Furuya, Jane Trepel, Dolores Di Vizio, Jlenia Guarnerio, Dan Theodorescu, Charles Rosser, Andrea Apolo, Matthew Galsky and Keith Syson Chan. https://www.nature.com/articles/s41467-022-29026-9


Phagoptosis


Knockout of the P2Y6 Receptor Prevents Peri-Infarct Neuronal Loss after Transient, Focal Ischemia in Mouse Brain – Stefan Milde and Guy C. Brown. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8879728/

Distinct roles in phagocytosis of the early and late increases of cell surface calreticulin induced by oxaliplatin – Kenju Matsusaka, Yutaro Azuma, Yuki Kaga, Saeka Uchida, Yuri Takebayashi, Takashi Tsuyama, Shusuke Tada. https://www.sciencedirect.com/science/article/pii/S2405580822000231

Phagocytosis and self-destruction break down dendrites of Drosophila sensory neurons at distinct steps of Wallerian degeneration – Hui Ji, Maria L Sapar, Ankita Sarkar, Bei Wang, Chun Han. https://www.pnas.org/doi/10.1073/pnas.2111818119


Miscellanous


Confined migration promotes cancer metastasis through resistance to anoikis and increased invasiveness – Deborah Fanfone, Zhichong Wu, Jade Mammi, Kevin Berthenet, David Neves, Kathrin Weber, Andrea Halaburkova, François Virard, Félix Bunel, Catherine Jamard, Hector Hernandez-Vargas, Stephen WG Tait, Ana Hennino, Gabriel Ichim. https://elifesciences.org/articles/73150

Copper induces cell death by targeting lipoylated TCA cycle proteins – Peter Tsvetkov, Shannon Coy, Boryana Petrova, Margaret Dreishpoon, Ana Verma, Mai Abdusamad, Jordan Rossen, Lena Joesch-Cohen, Ranad Humeidi, Ryan D. Spangler, John K. Eaton, Evgeni Frenkel, Mustafa Kocak, Steven M. Corsello, Svetlana Lutsenko, Naama Kanarek, Sandro Santagata, Todd R. Golub. https://www.science.org/doi/abs/10.1126/science.abf0529


Reviews


Tumor-intrinsic and immune modulatory roles of receptor-interacting protein kinases – Justin Rucker, Francis Ka-Ming Chan. https://www.cell.com/trends/biochemical-sciences/fulltext/S0968-0004(21)00273-5

Homing in on gasdermins: How fungi regulate cell death – Niklas A. Schmacke and Veit Hornung. https://www.pnas.org/doi/10.1073/pnas.2201192119?ai=aqle&ui=c8ih&af=T

Regulation of the release of damage-associated molecular patterns from necroptotic cells – Hiroyasu Nakano, Shin Murai, Kenta Moriwaki. https://portlandpress.com/biochemj/article-abstract/479/5/677/231045

Therapeutic approaches targeting CD95L/CD95 signaling in cancer and autoimmune diseases – Vesna Risso, Elodie Lafont and Matthieu Le Gallo. https://www.nature.com/articles/s41419-022-04688-x

Neuronal Loss after Stroke Due to Microglial Phagocytosis of Stressed Neurons – Guy C. Brown. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8707068/


Comments


The case for brakes: Why restrain the size of Bax and Bak pores in outer mitochondrial membranes? – David W. Andrews. https://www.cell.com/molecular-cell/fulltext/S1097-2765(22)00160-5

Copper-induced cell death – Martha A. Kahlson and Scott J. Dixon. https://www.science.org/doi/abs/10.1126/science.abo3959


Gordon Research Conference Cell Death.

Chair: Francis Chan. Vice Chair, Pascal Meier

Les Diablerets, Switzerland, May 15-20 2022. Application deadline April 22.

https://www.grc.org/cell-death-conference/2022

EWCD is ON this year in Fiuggi, Italy! 

Join us from June 26th – July 1st, 2022.

Abstract submission is open until April 8th but don’t wait, do it now 🙂    www.ewcd.eu

Looking forward to seeing faces again after 4 years!

ApoList – February 2022


Caspases and cFLIP


Executioner caspases 3 and 7 are dispensable for intestinal epithelium turnover and homeostasis at steady state – Farzaneh Ghazavi, Jelle Huysentruyt, Jordy De Coninck, Stephanie Kourula, Sofie Martens, Behrouz Hassannia, Tim Wartewig, Tatyana Divert, Ria Roelandt, Bastian Popper, Andreas Hiergeist, Peter Tougaard, Tom Vanden Berghe, Marie Joossens, Geert Berx, Nozomi Takahashi, Adam Wahida, and Peter Vandenabeele. https://www.pnas.org/content/119/6/e2024508119.abstract?etoc

cFLIP downregulation is an early event required for endoplasmic reticulum stress-induced apoptosis in tumor cells – Rocío Mora-Molina, Daniela Stöhr, Markus Rehm and Abelardo López-Rivas. https://www.nature.com/articles/s41419-022-04574-6

The deubiquitinase Usp27x as a novel regulator of cFIPL protein expression and sensitizer to death-receptor-induced apoptosis – Manuel Nico Dold, Xiulin Ng, Claudia Alber, Ian Edward Gentle, Georg Häcker, Arnim Weber. https://link.springer.com/article/10.1007/s10495-021-01706-9

Microfluidic deep mutational scanning of the human executioner caspases reveals differences in structure and regulation – Hridindu Roychowdury and Philip A. Romero. https://www.nature.com/articles/s41420-021-00799-0

Cell-to-cell variability in inducible Caspase9-mediated cell death – Yuan Yuan, Huixia Ren, Yanjun Li, Shanshan Qin, Xiaojing Yang and Chao Tang. https://www.nature.com/articles/s41419-021-04468-z

Blockade of caspase cascade overcomes malaria-associated acute respiratory distress syndrome in mice – Michelle K. Sercundes, Luana S. Ortolan, Viviane da Silva Julio, Leonardo M. Bella, Thatyane de Castro Quirino, Daniela Debone, Marcela S. Carneiro-Ramos, Marcelo A. Christoffolete, Joilson O. Martins, Maria Regina D’Império Lima, José M. Alvarez, Gustavo P. Amarante-Mendes, Lígia Antunes Gonçalves, Claudio R. F. Marinho and Sabrina Epiphanio. https://www.nature.com/articles/s41419-022-04582-6


Death receptors


Cell cycle progression and transmitotic apoptosis resistance promote escape from extrinsic apoptosis – Pollak N, Lindner A, Imig D, Kuritz K, Fritze JS, Decker L, Heinrich I, Stadager J, Eisler S, Allgöwer F, Scheurich P, Rehm M. https://journals.biologists.com/jcs/article/134/24/jcs258966/273757/Cell-cycle-progression-and-transmitotic-apoptosis | https://journals.biologists.com/jcs/article/134/24/jcs259602/273793/First-person-Nadine-Pollak

ER stress-induced cell death proceeds independently of the TRAIL-R2 signaling axis in pancreatic β cells – Cathrin Hagenlocher, Robin Siebert, Bruno Taschke, Senait Wieske, Angelika Hausser and Markus Rehm. https://www.nature.com/articles/s41420-022-00830-y

Focal adhesion kinase plays a dual role in TRAIL resistance and metastatic outgrowth of malignant melanoma – Greta Del Mistro, Shamala Riemann, Sebastian Schindler, Stefan Beissert, Roland E. Kontermann, Aurelien Ginolhac, Rashi Halder, Luana Presta, Lasse Sinkkonen, Thomas Sauter and Dagmar Kulms. https://www.nature.com/articles/s41419-022-04502-8


Necroptosis, RIPK


Site-specific ubiquitination of MLKL targets it to endosomes and targets Listeria and Yersinia to the lysosomes – Seongmin Yoon, Konstantin Bogdanov and David Wallach. https://www.nature.com/articles/s41418-021-00924-7

SMYD2 targets RIPK1 and restricts TNF-induced apoptosis and necroptosis to support colon tumor growth – Yu-qiang Yu, Veronika Thonn, Jay V. Patankar, Oana-Maria Thoma, Maximilian Waldner, Marta Zielinska, Li-li Bao, Miguel Gonzalez-Acera, Stefan Wallmüller, Felix B. Engel, Michael Stürzl, Markus F. Neurath, Eva Liebing and Christoph Becker. https://www.nature.com/articles/s41419-021-04483-0

Necroptosis triggers spatially restricted neutrophil-mediated vascular damage during lung ischemia reperfusion injury – Wenjun Li (et al) Ankit Bharat, and Daniel Kreisel. https://www.pnas.org/doi/10.1073/pnas.2111537119


Pyroptosis and gasdermins


Fungal gasdermin-like proteins are controlled by proteolytic cleavage – Corinne Clavé, Witold Dyrka, Elizabeth A. Turcotte, Alexandra Granger-Farbos, Léa Ibarlosa, Benoît Pinson, Russell E. Vance, Sven J. Saupe, and Asen Daskalov. https://www.pnas.org/content/119/7/e2109418119.abstract?etoc

Streptococcal pyrogenic exotoxin B cleaves GSDMA and triggers pyroptosis – Wanyan Deng, Yang Bai, Fan Deng, Youdong Pan, Shenglin Mei, Zengzhang Zheng, Rui Min, Zeyu Wu, Wu Li, Rui Miao, Zhibin Zhang, Thomas S. Kupper, Judy Lieberman and Xing Liu. https://www.nature.com/articles/s41586-021-04384-4

Electrostatic influence on IL-1 transport through the GSDMD pore – Wen Jun Xie, Shiyu Xia, Arieh Warshel, and Hao Wu. https://www.pnas.org/content/119/6/e2120287119.abstract?etoc

TRIM21 regulates pyroptotic cell death by promoting Gasdermin D oligomerization – Wenqing Gao, Yuanyuan Li, Xuehe Liu, Sen Wang, Pucheng Mei, Zijun Chen, Kewei Liu, Suhua Li, Xue-Wei Xu, Jianhua Gan, Jiaxue Wu, Chaoneng Ji, Chen Ding, Xing Liu, Yuping Lai, Housheng Hansen He, Judy Lieberman, Hao Wu, Xiangjun Chen and Jixi Li. https://www.nature.com/articles/s41418-021-00867-z

Epithelial Gasdermin D shapes the host-microbial interface by driving mucus layer formation – Jian Zhang, Qianzhou Yu, Danlu Jiang, Kang Yu, Weiwei Yu, Zhexu Chi, Sheng Chen, Mobai Li, Dehang Yang, Zhen Wang, Ting Xu, Xingchen Guo, Kailian Zhang, Hui Fang, Qizhen Ye, Yong He, Xue Zhang, Di Wang. https://www.science.org/doi/full/10.1126/sciimmunol.abk2092


Bcl-2 family proteins


Pediatric multicellular tumor spheroid models illustrate a therapeutic potential by combining BH3 mimetics with Natural Killer (NK) cell-based immunotherapy – Vinzenz Särchen, Senthan Shanmugalingam, Sarah Kehr, Lisa Marie Reindl, Victoria Greze, Sara Wiedemann, Cathinka Boedicker, Maureen Jacob, Katrin Bankov, Nina Becker, Sibylle Wehner, Till M. Theilen, Steffen Gretser, Elise Gradhand, Carsten Kummerow, Evelyn Ullrich and Meike Vogler. https://www.nature.com/articles/s41420-021-00812-6

MCL1 nuclear translocation induces chemoresistance in colorectal carcinoma – Dechen Fu, Luke Pfannenstiel, Abeba Demelash, Yee Peng Phoon, Cameron Mayell, Claudia Cabrera, Caini Liu, Junjie Zhao, Josephine Dermawan, Deepa Patil, Jennifer DeVecchio, Matthew Kalady, Andrew J. Souers, Darren C. Phillips, Xiaoxia Li and Brian Gastman. https://www.nature.com/articles/s41419-021-04334-y

DDX3 interacts with USP9X and participates in deubiquitination of the anti‐apoptotic protein MCL1 – Ming-Chih Lai, Yi-Pin Chen, Ding-An Li, Jau-Song Yu, Hsin-Yuan Hung, Woan-Yuh Tarn. https://febs.onlinelibrary.wiley.com/doi/abs/10.1111/febs.16219

BCL-XL inhibition induces an FGFR4-mediated rescue response in colorectal cancer – Prashanthi Ramesh, Simone Di Franco, Lidia Atencia Taboada, Le Zhang, Annalisa Nicotra, Giorgio Stassi, Jan Paul Medema. https://www.cell.com/cell-reports/fulltext/S2211-1247(22)00095-X

Clonal hematopoiesis, myeloid disorders and BAX-mutated myelopoiesis in patients receiving venetoclax for CLL – Piers Blombery, Thomas E. Lew, Michael A. Dengler, Ella R. Thompson, Victor S. Lin, Xiangting Chen, Tamia Nguyen, Ashish Panigrahi, Sasanka M. Handunnetti, Dennis A. Carney, David A. Westerman, Constantine S. Tam, Jerry M. Adams, Andrew H. Wei, David C. S. Huang, John F. Seymour, Andrew W. Roberts, Mary Ann Anderson. https://ashpublications.org/blood/article-abstract/139/8/1198/476749

The BCL-2 family member BOK promotes KRAS-driven lung cancer progression in a p53-dependent manner – Anna-Lena Meinhardt, Enkhtsetseg Munkhbaatar, Ulrike Höckendorf, Michelle Dietzen, Marta Dechant, Martina Anton, Anne Jacob, Katja Steiger, Wilko Weichert, Luka Brcic, Nicholas McGranahan, Caterina Branca, Thomas Kaufmann, Michael A. Dengler and Philipp J. Jost. https://www.nature.com/articles/s41388-021-02161-1

Non-canonical phosphorylation of Bmf by p38 MAPK promotes its apoptotic activity in anoikis – Zhe Zhi, Zhenlin Ouyang, Yibo Ren, Ying Cheng, Peijun Liu, Yurong Wen and Yongping Shao. https://www.nature.com/articles/s41418-021-00855-3

NOXA expression drives synthetic lethality to RUNX1 inhibition in pancreatic cancer – Josefina Doffo, Stefanos A. Bamopoulos (et al) and Matthias Wirth. https://www.pnas.org/doi/10.1073/pnas.2105691119


Ferroptosis


Targeting ferroptosis protects against experimental (multi)organ dysfunction and death – Samya Van Coillie, Emily Van San, Ines Goetschalckx, Bartosz Wiernicki, Banibrata Mukhopadhyay, Wulf Tonnus, Sze Men Choi, Ria Roelandt, Catalina Dumitrascu, Ludwig Lamberts, Geert Dams, Wannes Weyts, Jelle Huysentruyt, Behrouz Hassannia, Irina Ingold, Suhas Lele, Evelyne Meyer, Maya Berg, Ruth Seurinck, Yvan Saeys, An Vermeulen, Alexander L. N. van Nuijs, Marcus Conrad, Andreas Linkermann, Mohan Rajapurkar, Peter Vandenabeele, Eric Hoste, Koen Augustyns and Tom Vanden Berghe. https://www.nature.com/articles/s41467-022-28718-6

C-ferroptosis is an iron-dependent form of regulated cell death in cyanobacteria – Anabella Aguilera, Federico Berdun, Carlos Bartoli, Charlotte Steelheart, Matías Alegre, Hülya Bayir, Yulia Y. Tyurina, Valerian E. Kagan, Graciela Salerno, Gabriela Pagnussat, María Victoria Martin. https://rupress.org/jcb/article-abstract/221/2/e201911005/212878


Efferocytosis, entosis etc


Tumour cell apoptosis modulates the colorectal cancer immune microenvironment via interleukin-8-dependent neutrophil recruitment – Vanessa Schimek, Katharina Strasser, Andrea Beer, Samantha Göber, Natalie Walterskirchen, Christine Brostjan, Catharina Müller, Thomas Bachleitner-Hofmann, Michael Bergmann, Helmut Dolznig and Rudolf Oehler. https://www.nature.com/articles/s41419-022-04585-3

Autolysosomes and caspase-3 control the biogenesis and release of immunogenic apoptotic exosomes – Déborah Beillevaire, Francis Migneault, Julie Turgeon, Diane Gingras, Annie Karakeussian Rimbaud, Geneviève Marcoux, Crysta Spino, Nicolas Thibodeau, Eric Bonneil, Pierre Thibault, Éric Boilard, Mélanie Dieudé and Marie-Josée Hébert. https://www.nature.com/articles/s41419-022-04591-5

Necrotic debris and STING exert therapeutically relevant effects on tumor cholesterol homeostasis – Sampath Katakam, ProfileSantosh Anand, Patricia Martin, ProfileNicolo Riggi, ProfileIvan Stamenkovic. https://www.life-science-alliance.org/content/5/3/e202101256.abstract?etoc


Miscellanous


Functional visualization of NK cell-mediated killing of metastatic single tumor cells – Hiroshi Ichise, Shoko Tsukamoto, Tsuyoshi Hirashima, Yoshinobu Konishi, Choji Oki, Shinya Tsukiji, Satoshi Iwano, Atsushi Miyawaki, Kenta Sumiyama, Kenta Terai, Michiyuki Matsuda. https://elifesciences.org/articles/76269


Reviews


Regulation of extrinsic apoptotic signaling by c-FLIP: towards targeting cancer networks – Nikita V. Ivanisenko, Kamil Seyrek, Laura K. Hillert-Richter, Corinna König, Johannes Espe, Kakoli Bose, Inna N. Lavrik. https://www.cell.com/trends/cancer/fulltext/S2405-8033(21)00250-8

The concept of intrinsic versus extrinsic apoptosis – Laura Lossi. https://portlandpress.com/biochemj/article-abstract/479/3/357/230785

Double-edge sword roles of iron in driving energy production versus instigating ferroptosis – Shuping Zhang, Wei Xin, Gregory J. Anderson, Ruibin Li, Ling Gao, Shuguang Chen, Jiajun Zhao and Sijin Liu. https://www.nature.com/articles/s41419-021-04490-1

Collective effects in epithelial cell death and cell extrusion – Alexis Villars, Romain Levayer. https://www.sciencedirect.com/science/article/abs/pii/S0959437X21001106

Cell competition in vertebrates — a key machinery for tissue homeostasis – Takeshi Maruyama, Yasuyuki Fujita. https://www.sciencedirect.com/science/article/abs/pii/S0959437X2100118

Special issue Biochimica et Biophysica Acta (BBA) – Molecular Cell Research: “Death mechanisms in cellular homeostasis” Edited by Prof. Peter Ruvolo, Prof. Geert Bultynck. https://www.sciencedirect.com/journal/biochimica-et-biophysica-acta-bba-molecular-cell-research/special-issue/107S1CX8XZZ

Including, among others:

  • Cancer cell death strategies by targeting Bcl-2’s BH4 domain – Ian de Ridder, Martijn Kerkhofs, Santhini Pulikkal Veettil, Wim Dehaen, Geert Bultynck
  • It’s time to die: BH3 mimetics in solid tumors – Sarah Kehr, Meike Vogler
  • Death sentence: The tale of a fallen endoplasmic reticulum – Eoghan P. McGrath, Federica G. Centonze, Eric Chevet, Tony Avril, Elodie Lafont
  • Targeting epigenetic mechanisms to overcome venetoclax resistance – Gabriel Prado, Charlotte L. Kaestner, Jonathan D. Licht, Richard L. Bennett
  • Cell death as a result of calcium signaling modulation: A cancer-centric prospective – Alberto Danese, Sara Leo, Alessandro Rimessi, Mariusz R. Wieckowski, … Paolo Pinton

Persister cancer cells: Iron addiction and vulnerability to ferroptosis – Raphaël Rodriguez, Stuart L. Schreiber, Marcus Conrad. https://www.cell.com/molecular-cell/fulltext/S1097-2765(21)01038-8

Pyroptosis, a target for cancer treatment? – Ying Huang, Jian-Wei Wang, Jiao Huang, Lu Tang, Yun-Hua Xu, Hong Sun, Jie Tang, Guo Wang. https://link.springer.com/article/10.1007/s10495-021-01703-y


Comments


MLKL ubiquitylation: more than a makeover – Weihong Wang and Yi-Nan Gong. https://www.nature.com/articles/s41418-022-00934-z

A BAX door to venetoclax resistance – Franco Izzo, Dan A. Landau. https://ashpublications.org/blood/article/139/8/1124/484077/A-BAX-door-to-venetoclax-resistance

A lncRNA builds a glycolytic metabolon – Kim Baumann. https://www.nature.com/articles/s41580-022-00461-2


Conference:

EMBO Workshop “Dying in self-defense: cell death signaling in animals and plants”

Organized by Ana García and Panagiotis Moschou

1st – 5th May 2022 – Kalimera Kriti Hotel & Village Resort, Crete, Greece

https://meetings.embo.org/event/21-cell-death

ApoList – January 2022


Bcl-2 family proteins


BCL‐2‐family protein tBID can act as a BAX‐like effector of apoptosis – Hector Flores-Romero, Lisa Hohorst, Malina John, Marie-Christine Albert, Louise E King, Laura Beckmann, Tamas Szabo, Vanessa Hertlein, Xu Luo, Andreas Villunger, Lukas P Frenzel, Hamid Kashkar, Ana J Garcia-Saez. https://www.embopress.org/doi/full/10.15252/embj.2021108690

Structural basis of BAK activation in mitochondrial apoptosis initiation – Geetika Singh, Cristina D. Guibao and Tudor Moldoveanu. https://www.nature.com/articles/s41467-021-27851-y

Targeting Cpt1a-Bcl-2 interaction modulates apoptosis resistance and fibrotic remodeling – Linlin Gu, Ranu Surolia, Jennifer L. Larson-Casey, Chao He, Dana Davis, Jungsoon Kang, Veena B. Antony and A. Brent Carter. https://www.nature.com/articles/s41418-021-00840-w

The BCL-2 family member BOK promotes KRAS-driven lung cancer progression in a p53-dependent manner – Anna-Lena Meinhardt, Enkhtsetseg Munkhbaatar, Ulrike Höckendorf, Michelle Dietzen, Marta Dechant, Martina Anton, Anne Jacob, Katja Steiger, Wilko Weichert, Luka Brcic, Nicholas McGranahan, Caterina Branca, Thomas Kaufmann, Michael A. Dengler and Philipp J. Jost. https://www.nature.com/articles/s41388-021-02161-1


Efferocytosis, tissue homeostasis


Sensing plasma membrane pore formation induces chemokine production in survivors of regulated necrosis – Weihong Wang, Joshua S. Prokopec, Yixin Zhang, Maria Sukhoplyasova, Himaly Shinglot, Man-Tzu Wang, Andreas Linkermann, Jacob Stewart-Ornstein, Yi-Nan Gong. https://www.cell.com/developmental-cell/fulltext/S1534-5807(21)01035-2

Polyamine import and accumulation causes immunomodulation in macrophages engulfing apoptotic cells – Alexandra L. McCubbrey, Shannon A. McManus, Jazalle D. McClendon, Stacey M. Thomas, Hope B. Chatwin, Julie A. Reisz, Angelo D’Alessandro, Kara J. Mould, Donna L. Bratton, Peter M. Henson, William J. Janssen. https://www.cell.com/cell-reports/fulltext/S2211-1247(21)01726-5

Rapid lamellipodial responses by neighbor cells drive epithelial sealing in response to pyroptotic cell death – Alexis Bonfim-Melo, Ivar Noordstra, Shafali Gupta, Amy H. Chan, Mathew J.K. Jones, Kate Schroder, Alpha S. Yap. https://www.cell.com/cell-reports/fulltext/S2211-1247(22)00027-4


Caspases and IAPs


Drice restrains Diap2-mediated inflammatory signalling and intestinal inflammation – Christa Kietz, Aravind K. Mohan, Vilma Pollari, Ida-Emma Tuominen, Paulo S. Ribeiro, Pascal Meier and Annika Meinander. https://www.nature.com/articles/s41418-021-00832-w


Death receptors, necroptosis


Targeting necroptosis in muscle fibers ameliorates inflammatory myopathies – Mari Kamiya, Fumitaka Mizoguchi, Kimito Kawahata, Dengli Wang, Masahiro Nishibori, Jessica Day, Cynthia Louis, Ian P. Wicks, Hitoshi Kohsaka and Shinsuke Yasuda. https://www.nature.com/articles/s41467-021-27875-4


Pyroptosis


Bacterial gasdermins reveal an ancient mechanism of cell death – Alex G. Johnson, Tanita Wein, Megan L. Mayer, Brianna Duncan-Lowey, Erez Yirmiya, Yaara Oppenheimer-Shaanan, Gil Amitai, Rotem Sorek, Philip J. Kranzusch. https://www.science.org/doi/abs/10.1126/science.abj8432

GSDMB is increased in IBD and regulates epithelial restitution/repair independent of pyroptosis – Nitish Rana, Giuseppe Privitera, Hannah C. Kondolf, Katarzyna Bulek, Susana Lechuga, Carlo De Salvo, Daniele Corridoni, Agne Antanaviciute, Rebecca L. Maywald, Alexander M. Hurtado, Junjie Zhao, Emina H. Huang, Xiaoxia Li, E. Ricky Chan, Alison Simmons, Giorgos Bamias, Derek W. Abbott, Jason D. Heaney, Andrei I. Ivanov, Theresa T. Pizarro. https://www.cell.com/cell/fulltext/S0092-8674(21)01487-2

Gasdermin D pores are dynamically regulated by local phosphoinositide circuitry – Ana Beatriz Santa Cruz Garcia, Kevin P. Schnur and Gary C. H. Mo. https://www.nature.com/articles/s41467-021-27692-9

Streptococcal pyrogenic exotoxin B cleaves GSDMA and triggers pyroptosis – Wanyan Deng, Yang Bai, Fan Deng, Youdong Pan, Shenglin Mei, Zengzhang Zheng, Rui Min, Zeyu Wu, Wu Li, Rui Miao, Zhibin Zhang, Thomas S. Kupper, Judy Lieberman and Xing Liu. https://www.nature.com/articles/s41586-021-04384-4


Ferroptosis


Dexamethasone Sensitizes to Ferroptosis by Glucocorticoid Receptor-induced Dipeptidase-1 expression and Glutathione Depletion – von Mässenhausen A, Zamora Gonzalez N, Maremonti F, Belavgeni A, Tonnus W, Meyer C, Beer K, Hannani MT, Lau A, Peitzsch M, Hoppenz P, Locke S, Chavakis T, Kramann R, Muruve DA, Hugo C, Bornstein SR, Linkermann A. https://www.science.org/doi/10.1126/sciadv.abl8920

PKCβII phosphorylates ACSL4 to amplify lipid peroxidation to induce ferroptosis – Hai-Liang Zhang, Bing-Xin Hu, Zhi-Ling Li, Tian Du, Jia-Lu Shan, Zhi-Peng Ye, Xiao-Dan Peng, Xuan Li, Yun Huang, Xian-Ying Zhu, Yu-Hong Chen, Gong-Kan Feng, Dajun Yang, Rong Deng and Xiao-Feng Zhu. https://www.nature.com/articles/s41556-021-00818-3


Miscellanous


Senescence induction dictates response to chemo- and immunotherapy in preclinical models of ovarian cancer – Stella V. Paffenholz, Camilla Salvagno, Yu-Jui Ho, Matthew Limjoco, Timour Baslan, Sha Tian, Amanda Kulick, Elisa de Stanchina, John E. Wilkinson, Francisco M. Barriga, Dmitriy Zamarin, Juan R. Cubillos-Ruiz, Josef Leibold, and Scott W. Lowe. https://www.pnas.org/content/119/5/e2117754119.abstract?etoc

Bacillus anthracis induces NLRP3 inflammasome activation and caspase-8–mediated apoptosis of macrophages to promote lethal anthrax – Filip Van Hauwermeiren, Nina Van Opdenbosch, Hanne Van Gorp, Nathalia de Vasconcelos, Geert van Loo, Peter Vandenabeele, Thirumala-Devi Kanneganti, and Mohamed Lamkanfi. https://www.pnas.org/content/119/2/e2116415119.abstract


Reviews/comments


The complex interplay between autophagy and cell death pathways – Christina Ploumi, Margarita-Elena Papandreou, Nektarios Tavernarakis. https://portlandpress.com/biochemj/article-abstract/479/1/75/230651

The role of Ubiquitination in Apoptosis and Necroptosis – Jamie Z. Roberts, Nyree Crawford and Daniel B. Longley. https://www.nature.com/articles/s41418-021-00922-9

Cellular senescence: all roads lead to mitochondria – Hélène Martini, João F. Passos. https://febs.onlinelibrary.wiley.com/doi/full/10.1111/febs.16361#.Yfhngl2bq4U

Positive feedback amplifies ferroptosis – Jason Rodencal & Scott J. Dixon. https://www.nature.com/articles/s41556-021-00824-5