ApoList – October 2018


Bcl-2 family proteins


Humanized Mcl-1 mice enable accurate preclinical evaluation of MCL-1 inhibitors destined for clinical use – Margs S. Brennan, Catherine Chang, Lin Tai, Guillaume Lessene, Andreas  Strasser, Grant Dewson, Gemma L. Kelly and Marco J. Herold. http://bloodjournal.org/content/132/15/1573.abstract?etoc

Discovery of a small-molecule inhibitor of specific serine residue BAD phosphorylation – Vijay Pandey, Baocheng Wang, Chakrabhavi Dhananjaya Mohan, Ainiah Rushdiana Raquib, Shobith Rangappa, Venkatachalaiah Srinivasa, Julian E. Fuchs, Kesturu S. Girish, Tao Zhu, Andreas Bender, Lan Ma, Zhinan Yin, Basappa, Kanchugarakoppal S. Rangappa and Peter E. Lobie. http://www.pnas.org/content/115/44/E10505?etoc=

Activation of the apoptotic pathway during prolonged prometaphase blocks daughter cell proliferation – Yumi Uetake and Greenfield Sluder. https://www.molbiolcell.org/doi/10.1091/mbc.E18-01-0026?ai=s5&ui=2oy6&af=T

Ursolic acid facilitates apoptosis in rheumatoid arthritis synovial fibroblasts by inducing SP1-mediated Noxa expression and proteasomal degradation of Mcl-1 – Eugene Y. Kim, Kuladeep Sudini, Anil K. Singh, Mahamudul Haque, Douglas Leaman, Sadik Khuder and Salahuddin Ahmed. https://www.fasebj.org/doi/abs/10.1096/fj.201800425R?ai=s4&ui=ly8&af=T

Tyrosine Kinase Inhibitors Increase MCL1 Degradation and in Combination with BCLXL/BCL2 Inhibitors Drive Prostate Cancer Apoptosis – Seiji Arai, Oliver Jonas, Matthew A. Whitman, Eva Corey, Steven P. Balk and Sen Chen. http://clincancerres.aacrjournals.org/content/24/21/5458


Death receptors


CD95/Fas ligand mRNA is toxic to cells – Will Putzbach, Ashley Haluck-Kangas … Marcus E Peter. https://elifesciences.org/articles/38621

Linear ubiquitination of cFLIP induced by LUBAC contributes to TNFa-induced apoptosis – Yong Tang, Donghyun Joo, Guangna Liu, Hailin Tu, Jeffrey You, Jianping Jin, Xueqiang Zhao, Mien-Chie Hung and Xin Lin. http://www.jbc.org/content/early/2018/10/25/jbc.RA118.005449.abstract


Caspases


Picomolar zinc binding modulates formation of Bcl10-nucleating assemblies of the caspase recruitment domain (CARD) of CARD9 – Michael J. Holliday, Ryan Ferrao, Gladys de Leon Boenig, Alberto Estevez, Elizabeth Helgason, Alexis Rohou, Erin C. Dueber and Wayne J. Fairbrother. http://www.jbc.org/content/293/43/16803.abstract.html

Cryo-EM structures of ASC and NLRC4 CARD filaments reveal a unified mechanism of nucleation and activation of caspase-1 – Yang Li, Tian-Min Fu, Alvin Lu, Kristen Witt, Jianbin Ruan, Chen Shen and Hao Wu. http://www.pnas.org/content/115/43/10845?etoc=


Efferocytosis


LC3-Associated Phagocytosis in Myeloid Cells Promotes Tumor Immune Tolerance – Larissa D. Cunha, Mao Yang, Robert Carter, Clifford Guy, Lacie Harris, Jeremy C. Crawford, Giovanni Quarato, Emilio Boada-Romero, Halime Kalkavan, Michael D.L. Johnson, Sivaraman Natarajan, Meghan E. Turnis, David Finkelstein, Joseph T. Opferman, Charles Gawad, Douglas R. Green. https://www.cell.com/cell/fulltext/S0092-8674(18)31122-X

Regulatory T Cells Promote Macrophage Efferocytosis during Inflammation Resolution – Jonathan D. Proto, Amanda C. Doran, Galina Gusarova, Arif Yurdagul Jr., Erdi Sozen, Manikandan Subramanian, Mohammad N. Islam, Christina C. Rymond, Jasper Du, Jaime Hook, George Kuriakose, Jahar Bhattacharya, Ira Tabas. https://www.cell.com/immunity/fulltext/S1074-7613(18)30335-2

RAB-35 and ARF-6 GTPases Mediate Engulfment and Clearance Following Linker Cell-Type Death – Lena M. Kutscher, Wolfgang Keil, Shai Shaham. https://www.cell.com/developmental-cell/fulltext/S1534-5807(18)30685-3

Apoptotic β-cells induce macrophage reprogramming under diabetic conditions – Meliza G. Ward, Ge Li and Mingming Hao. http://www.jbc.org/content/293/42/16160.abstract.html


Ferroptosis


The glutathione redox system is essential to prevent ferroptosis caused by impaired lipid metabolism in clear cell renal cell carcinoma – Heike Miess, Beatrice Dankworth, Arvin M. Gouw, Mathias Rosenfeldt, Werner Schmitz, Ming Jiang, Becky Saunders, Michael Howell, Julian Downward, Dean W. Felsher, Barrie Peck and Almut Schulze. https://www.nature.com/articles/s41388-018-0315-z

Activation of ferritinophagy is required for the RNA-binding protein ELAVL1/HuR to regulate ferroptosis in hepatic stellate cells – Zili Zhang, Zhen Yao, Ling Wang, Hai Ding, Jiangjuan Shao, Anping Chen, Feng Zhang and Shizhong Zheng. https://www.tandfonline.com/doi/full/10.1080/15548627.2018.1503146


Miscellanous


Mixed Lineage Kinase Domain-like Protein MLKL Breaks Down Myelin following Nerve Injury – Zhengxin Ying, Chenjie Pan, Tianyu Shao, Liqing Liu, Lin Li, Dejia Guo, Sitao Zhang, Tianyi Yuan, Ran Cao, Zhaodi Jiang, She Chen, Fengchao Wang, Xiaodong Wang. https://www.cell.com/molecular-cell/fulltext/S1097-2765(18)30782-2

Global Profiling of Proteolysis from the Mitochondrial Amino Terminome during Early Intrinsic Apoptosis Prior to Caspase-3 Activation – Natalie C. Marshall, Theo Klein, Maichael Thejoe, Niklas von Krosigk, Jayachandran Kizhakkedathu, B. Brett Finlay and Christopher M. Overall. https://pubs.acs.org/doi/10.1021/acs.jproteome.8b00675#.W9q0UN6qJiJ

Siglec-7 engagement by GBS β-protein suppresses pyroptotic cell death of natural killer cells – Jerry J. Fong, Chih-Ming Tsai, Sudeshna Saha, Victor Nizet, Ajit Varki and Jack D. Bui. http://www.pnas.org/content/115/41/10410?etoc=

Subcellular Hsp70 Inhibitors Promote Cancer Cell Death via Different Mechanisms – Sang-Hyun Park, Kyung-Hwa Baek, Insu Shin, Injae Shin. https://www.sciencedirect.com/science/article/pii/S2451945618302241


Reviews


Topology of active, membrane-embedded Bax in the context of a toroidal pore – Stephanie Bleicken, Tufa E. Assafa, Carolin Stegmueller, Alice Wittig, Ana J. Garcia-Saez and Enrica Bordignon. https://www.nature.com/articles/s41418-018-0184-6

Neurophagy, the phagocytosis of live neurons and synapses by glia, contributes to brain development and disease – Anna Vilalta, Guy C. Brown. https://febs.onlinelibrary.wiley.com/doi/10.1111/febs.14323

No Parkin Zone: Mitophagy without Parkin – Elodie Villa, Sandrine Marchetti, Jean-Ehrland Ricci. https://www.cell.com/trends/cell-biology/fulltext/S0962-8924(18)30125-9


Comments


MIM through MOM: the awakening of Bax and Bak pores – Katia Cosentino, Ana J García‐Sáez. http://emboj.embopress.org/content/37/17/e100340

MLKL Reveals Its Friendly Face: A Role in Nerve Regeneration – Peter Vandenabeele, Wim Declercq, Ria Roelandt, Tom Vanden Berghe. https://www.cell.com/molecular-cell/fulltext/S1097-2765(18)30885-2

Neighbourhood deaths cause a switch in cancer subtype – Eli Pikarsky. https://www.nature.com/articles/d41586-018-06217-3

Neighbourly deaths dictate fatehttps://www.nature.com/articles/s41568-018-0064-x

Annual Meeting of the International Society of Cancer Metabolism (ISCaM): Cancer Metabolism – Sofia Avnet, Nicola Baldini, Lucie Brisson, Angelo De Milito, Angela M. Otto, Silvia Pastoreková, Paolo E. Porporato, Gyorgy Szabadkai and Pierre Sonveaux. https://www.frontiersin.org/articles/10.3389/fonc.2018.00329/full

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ApoList – September 2018

 


Caspases and cFLIP


ER Stress Drives Lipogenesis and Steatohepatitis via Caspase-2 Activation of S1P – Ju Youn Kim, Ricard Garcia-Carbonell, Shinichiro Yamachika, Peng Zhao, Debanjan Dhar, Rohit Loomba, Randal J. Kaufman, Alan R. Saltiel, Michael Karin. https://www.cell.com/cell/fulltext/S0092-8674(18)31036-5

Caspase-1 inhibition alleviates cognitive impairment and neuropathology in an Alzheimer’s disease mouse model – Joseph Flores, Anastasia Noël, Bénédicte Foveau, Jeffrey Lynham, Clotilde Lecrux & Andréa C. LeBlanc. https://www.nature.com/articles/s41467-018-06449-x

Inhibitor of apoptosis proteins (IAPs) mediate collagen type XI alpha 1-driven cisplatin resistance in ovarian cancer – Miran Rada, Sameera Nallanthighal, Jennifer Cha, Kerry Ryan, Jessica Sage, Catherine Eldred, Maria Ullo, Sandra Orsulic & Dong-Joo Cheon. https://www.nature.com/articles/s41388-018-0297-x

Hypercapnia increases airway smooth muscle contractility via caspase-7-mediated miR-133a-RhoA signaling – Masahiko Shigemura , Emilia Lecuona, Martín Angulo, Tetsuya Homma, Diego A. Rodríguez, Francisco J. Gonzalez-Gonzalez, Lynn C. Welch, Luciano Amarelle, Seok-Jo Kim, Naftali Kaminski, G. R. Scott Budinger, Julian Solway, Jacob I. Sznajder. http://stm.sciencemag.org/content/10/457/eaat1662

PIDD-dependent activation of caspase-2-mediated mitochondrial injury in E1A-induced cellular sensitivity to macrophage nitric oxide-induced apoptosis – Jay R. Radke, Iris Figueroa, John M. Routes & James L. Cook. https://www.nature.com/articles/s41420-018-0100-3

Release of c-FLIP brake selectively sensitizes human cancer cells to TLR3-mediated apoptosis – Lugain Alkurdi, François Virard, Béatrice Vanbervliet, Kathrin Weber, Florent Toscano, Marc Bonnin, Nolwenn Le Stang, Sylvie Lantuejoul, Olivier Micheau, Toufic Renno, Serge Lebecque & Yann Estornes. https://www.nature.com/articles/s41419-018-0850-0


Bcl-2 family proteins


Phosphorylation switches Bax from promoting to inhibiting apoptosis thereby increasing drug resistance – Justin Kale, Ozgur Kutuk, Glauber Costa Brito, Tallulah S Andrews, Brian Leber, Anthony Letai and David W Andrews. http://EMBOr.embopress.org/content/19/9/e45235?etoc

Topology of active, membrane-embedded Bax in the context of a toroidal pore – Stephanie Bleicken, Tufa E. Assafa, Carolin Stegmueller, Alice Wittig, Ana J. Garcia-Saez & Enrica Bordignon. https://www.nature.com/articles/s41418-018-0184-6

Atypical APC/C‐dependent degradation of Mcl‐1 provides an apoptotic timer during mitotic arrest – Lindsey A Allan, Agnieszka Skowyra, Katie I Rogers, Désirée Zeller and Paul R Clarke. http://EMBOJ.embopress.org/content/37/17/e96831?etoc

Comprehensive Safety Analysis of Venetoclax Monotherapy for Patients with Relapsed/Refractory Chronic Lymphocytic Leukemia – Matthew S. Davids, Michael Hallek, William Wierda, Andrew W. Roberts, Stephan Stilgenbauer, Jeffrey A. Jones, John F. Gerecitano, Su Young Kim, Jalaja Potluri, Todd Busman, Andrea Best, Maria E. Verdugo, Elisa Cerri, Monali Desai, Peter Hillmen and John F. Seymour. http://clincancerres.aacrjournals.org/content/24/18/4371

SNAP23 regulates BAX-dependent adipocyte programmed cell death independently of canonical macroautophagy – Daorong Feng, Dulguun Amgalan, Rajat Singh, Jianwen Wei, Jennifer Wen, Tszki Peter Wei, Timothy E. McGraw, Richard N. Kitsis, and Jeffrey E. Pessin. https://www.jci.org/articles/view/99217

BCL-2 selective inhibitor ABT-199 primes rhabdomyosarcoma cells to histone deacetylase inhibitor-induced apoptosis – Ulrike Heinicke, Tinka Haydn, Sarah Kehr, Meike Vogler & Simone Fulda. https://www.nature.com/articles/s41388-018-0212-5

Bcl-xl as the most promising Bcl-2 family member in targeted treatment of chondrosarcoma – Yvonne de Jong, David Monderer, Emeline Brandinelli, Morgane Monchanin, Brendy E. van den Akker, Jolieke G. van Oosterwijk, Jean Yves Blay, Aurélie Dutour & Judith V. M. G. Bovée. https://www.nature.com/articles/s41389-018-0084-0

Mex-3B induces apoptosis by inhibiting miR-92a access to the Bim-3’UTR – Takeaki Oda, Yusuke Yamazumi, Takatoshi Hiroko, Atsushi Kamiya, Saori Kiriya, Saki Suyama, Yumi Shiozaki-Sato & Tetsu Akiyama. https://www.nature.com/articles/s41388-018-0336-7

MEK inhibitors induce apoptosis via FoxO3a-dependent PUMA induction in colorectal cancer cells – Lin Lin, Dapeng Ding, Yanmei Jiang, Yan Li & Shijun Li. https://www.nature.com/articles/s41389-018-0078-y

Subtle Changes in the Levels of BCL-2 Proteins Cause Severe Craniofacial Abnormalities – Stephanie Grabow, Andrew J. Kueh, Francine Ke, Hannah K. Vanyai, Bilal N. Sheikh, Michael A. Dengler, William Chiang, Samantha Eccles, Ian M. Smyth, Lynelle K. Jones, Frederic J. de Sauvage, Mark Scott, Lachlan Whitehead, Anne K. Voss, Andreas Strasser. https://www.cell.com/cell-reports/fulltext/S2211-1247(18)31334-2

Misoprostol regulates Bnip3 repression and alternative splicing to control cellular calcium homeostasis during hypoxic stress – Jared T. Field, Matthew D. Martens, Wajihah Mughal, Yan Hai, Donald Chapman, Grant M. Hatch, Tammy L. Ivanco, William Diehl-Jones & Joseph W. Gordon. https://www.nature.com/articles/s41420-018-0104-z

BH3 mimetics induce apoptosis independent of DRP-1 in melanoma – Nabanita Mukherjee, Andrew Strosnider, Bay Vagher, Karoline A. Lambert, Sarah Slaven, William A. Robinson, Carol M. Amato, Kasey L. Couts, Judson G. T. Bemis, Jacqueline A. Turner, David A. Norris& Yiqun G. Shellman. https://www.nature.com/articles/s41419-018-0932-z

Sensitizing non-small cell lung cancer to BCL-xL-targeted apoptosis – Qi Shen, Jun Li, Junhua Mai, Zhe Zhang, Andrew Fisher, Xiaoyan Wu, Zhaoqi Li, Maricela R. Ramirez, Shuqing Chen & Haifa Shen. https://www.nature.com/articles/s41419-018-1040-9


Death receptors


LUBAC prevents lethal dermatitis by inhibiting cell death induced by TNF, TRAIL and CD95L – Lucia Taraborrelli, Nieves Peltzer, Antonella Montinaro, Sebastian Kupka, Eva Rieser, Torsten Hartwig, Aida Sarr, Maurice Darding, Peter Draber, Tobias L. Haas, Ayse Akarca, Teresa Marafioti, Manolis Pasparakis, John Bertin, Peter J. Gough, Philippe Bouillet, Andreas Strasser, Martin Leverkus, John Silke & Henning Walczak. https://www.nature.com/articles/s41467-018-06155-8

Delivery of a TNF-α–derived peptide by nanoparticles enhances its antitumor activity by inducing cell-cycle arrest and caspase-dependent apoptosis – Qiuxia Yan, Xueming Chen, Huizhen Gong, Pei Qiu, Xing Xiao, Shiying Dang, An Hong, and Yi Ma. https://www.fasebj.org/doi/abs/10.1096/fj.201800377R?ai=ts&ui=ly8&af=T

Platelet-RBC interaction mediated by FasL/FasR induces procoagulant activity important for thrombosis – Christoph Klatt, Irena Krüger, Saskia Zey, Kim-Jürgen Krott, Martina Spelleken, Nina Sarah Gowert, Alexander Oberhuber, Lena Pfaff, Wiebke Lückstädt, Kerstin Jurk, Martin Schaller, Hadi Al-Hasani, Jürgen Schrader, Steffen Massberg, Konstantin Stark, Hubert Schelzig, Malte Kelm, and Margitta Elvers. https://www.jci.org/articles/view/92077

Elevated A20 promotes TNF-induced and RIPK1-dependent intestinal epithelial cell death – Ricard Garcia-Carbonell, Jerry Wong, Ju Youn Kim, Lisa Abernathy Close, Brigid S. Boland, Thomas L. Wong, Philip A. Harris, Samuel B. Ho, Soumita Das, Peter B. Ernst, Roman Sasik, William J. Sandborn, John Bertin, Pete J. Gough, John T. Chang, Michelle Kelliher, David Boone, Monica Guma, and Michael Karin. http://www.pnas.org/content/115/39/E9192?etoc=

K6 linked polyubiquitylation of FADD by CHIP prevents death inducing signaling complex formation suppressing cell death – Jinho Seo, Eun-Woo Lee, Jihye Shin, Daehyeon Seong, Young Woo Nam, Manhyung Jeong, Seon-Hyeong Lee, Cheolju Lee & Jaewhan Song. https://www.nature.com/articles/s41388-018-0323-z

TNFR2 unlocks a RIPK1 kinase activity-dependent mode of proinflammatory TNFR1 signaling – Daniela Siegmund, Martin Ehrenschwender & Harald Wajant. https://www.nature.com/articles/s41419-018-0973-3

Ceramide synthase-6 confers resistance to chemotherapy by binding to CD95/Fas in T-cell acute lymphoblastic leukemia – Dattesh Verlekar, Sung-Jen Wei, Hwangeui Cho, Shengping Yang & Min H. Kang. https://www.nature.com/articles/s41419-018-0964-4

TNFα sensitizes hepatocytes to FasL-induced apoptosis by NFκB-mediated Fas upregulation – Laura Faletti, Lukas Peintner, Simon Neumann, Sandra Sandler, Thomas Grabinger, Sabine Mac Nelly, Irmgard Merfort, Chun-Hao Huang, Darjus Tschaharganeh, Tae-Won Kang, Florian Heinzmann, Luana D’Artista, Ulrich Maurer, Thomas Brunner, Scott Lowe, Lars Zender & Christoph Borner. https://www.nature.com/articles/s41419-018-0935-9


Necroptosis, RIP kinases, MLKL


Necroptosis microenvironment directs lineage commitment in liver cancer – Marco Seehawer, Florian Heinzmann, Luana D’Artista, Jule Harbig, Pierre-François Roux, Lisa Hoenicke, Hien Dang, Sabrina Klotz, Lucas Robinson, Grégory Doré, Nir Rozenblum, Tae-Won Kang, Rishabh Chawla, Thorsten Buch, Mihael Vucur, Mareike Roth, Johannes Zuber, Tom Luedde, Bence Sipos, Thomas Longerich, Mathias Heikenwälder, Xin Wei Wang, Oliver Bischof & Lars Zender. https://www.nature.com/articles/s41586-018-0519-y

TBK1 Suppresses RIPK1-Driven Apoptosis and Inflammation during Development and in Aging – Daichao Xu, Taijie Jin, Hong Zhu, Hongbo Chen, Dimitry Ofengeim, Chengyu Zou, Lauren Mifflin, Lifeng Pan, Palak Amin, Wanjin Li, Bing Shan, Masanori Gomi Naito, Huyan Meng, Ying Li, Heling Pan, Liviu Aron, Xian Adiconis, Joshua Z. Levin, Bruce A. Yankner, Junying Yuan. https://www.cell.com/cell/fulltext/S0092-8674(18)30969-3

Necroptosis mediates myofibre death in dystrophin-deficient mice – Jennifer E. Morgan, Alexandre Prola, Virginie Mariot, Veronica Pini, Jinhong Meng, Christophe Hourde, Julie Dumonceaux, Francesco Conti, Frederic Relaix, Francois-Jerôme Authier, Laurent Tiret, Francesco Muntoni & Maximilien Bencze. https://www.nature.com/articles/s41467-018-06057-9

RIPK3-MLKL-mediated necroinflammation contributes to AKI progression to CKD – Hui Chen, Yulu Fang, Jianfeng Wu, Hong Chen, Zhenhuan Zou, Xiaohong Zhang, Jing Shao & Yanfang Xu. https://www.nature.com/articles/s41419-018-0936-8

RIPK1 is a critical modulator of both tonic and TLR-responsive inflammatory and cell death pathways in human macrophage differentiation – Julian Buchrieser, Maria Jose Oliva-Martin, Michael D. Moore, Joshua C. D. Long, Sally A. Cowley, Jose Antonio Perez-Simón, William James & Jose Luis Venero. https://www.nature.com/articles/s41419-018-1053-4

BRAF and AXL oncogenes drive RIPK3 expression loss in cancer – Ayaz Najafov , Ioannis K. Zervantonakis, Adnan K. Mookhtiar, Patricia Greninger, Ryan J. March, Regina K. Egan, Hoang Son Luu, Daniel G. Stover, Ursula A. Matulonis, Cyril H. Benes, Junying Yuan. https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.2005756

The pseudokinase MLKL activates PAD4-dependent NET formation in necroptotic neutrophils – Akshay A. D’Cruz , Mary Speir, Meghan Bliss-Moreau, Sylvia Dietrich, Shu Wang, Alyce A. Chen, Mathilde Gavillet, Arshed Al-Obeidi, Kate E. Lawlor, James E. Vince, Michelle A. Kelliher, Razq Hakem, Manolis Pasparakis, David A. Williams, Maria Ericsson, Ben A. Croker. http://stke.sciencemag.org/content/11/546/eaao1716

The brace helices of MLKL mediate interdomain communication and oligomerisation to regulate cell death by necroptosis – Katherine A. Davies, Maria C. Tanzer, Michael D. W. Griffin, Yee Foong Mok, Samuel N. Young, Rui Qin, Emma J. Petrie, Peter E. Czabotar, John Silke & James M. Murphy. https://www.nature.com/articles/s41418-018-0061-3


Miscellanous


Natural killer cells induce distinct modes of cancer cell death: Discrimination, quantification and modulation of apoptosis, necrosis and mixed forms – Christian S Backes, Kim S Friedmann, Sebastian Mang, Arne Knörck, Markus Hoth and Carsten Kummerow. http://www.jbc.org/content/early/2018/09/06/jbc.RA118.004549.abstract

DPP8/DPP9 inhibitor-induced pyroptosis for treatment of acute myeloid leukemia – Darren C. Johnson, Cornelius Y. Taabazuing, Marian C. Okondo, Ashley J. Chui, Sahana D. Rao, Fiona C. Brown, Casie Reed, Elizabeth Peguero, Elisa de Stanchina, Alex Kentsis & Daniel A. Bachovchin. https://www.nature.com/articles/s41591-018-0082-y

The small GTPase RAB-35 defines a third pathway that is required for the recognition and degradation of apoptotic cells – Ryan Haley, Ying Wang, Zheng Zhou. https://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1007558

Cell-to-Cell Heterogeneity in p38-Mediated Cross-Inhibition of JNK Causes Stochastic Cell Death – Haruko Miura, Yohei Kondo, Michiyuki Matsuda, Kazuhiro Aoki. https://www.cell.com/cell-reports/fulltext/S2211-1247(18)31274-9

Tryparedoxin peroxidase-deficiency commits trypanosomes to ferroptosis-type cell death – Marta Bogacz, R Luise Krauth-Siegel. https://elifesciences.org/articles/37503

BAP1 links metabolic regulation of ferroptosis to tumour suppression – Yilei Zhang, Jiejun Shi, Xiaoguang Liu, Li Feng, Zihua Gong, Pranavi Koppula, Kapil Sirohi, Xu Li, Yongkun Wei, Hyemin Lee, Li Zhuang, Gang Chen, Zhen-Dong Xiao, Mien-Chie Hung, Junjie Chen, Peng Huang, Wei Li & Boyi Gan. https://www.nature.com/articles/s41556-018-0178-0

Gasdermin D Restrains Type I Interferon Response to Cytosolic DNA by Disrupting Ionic Homeostasis – Ishita Banerjee, Bharat Behl, Morena Mendonca, Gaurav Shrivastava, Ashley J. Russo, Antoine Menoret, Arundhati Ghosh, Anthony T. Vella, Sivapriya Kailasan Vanaja, Saumendra N. Sarkar, Katherine A. Fitzgerald, Vijay A.K. Rathinam. https://www.cell.com/immunity/fulltext/S1074-7613(18)30326-1

Dynein links engulfment and execution of apoptosis via CED-4/Apaf1 in C. elegans – Rikke Hindsgaul Harders, Tine Hørning Morthorst, Anna Dippel Lande, Marianne Overgaard Hesselager, Ole Aalund Mandrup, Emøke Bendixen, Allan Stensballe & Anders Olsen. https://www.nature.com/articles/s41419-018-1067-y


Reviews


Life, death and autophagy – Johnna Doherty & Eric H. Baehrecke. https://www.nature.com/articles/s41556-018-0201-5

Nutrient scavenging in cancer – Brendan T. Finicle, Vaishali Jayashankar & Aimee L. Edinger. https://www.nature.com/articles/s41568-018-0048-x

BCL-2 inhibition in AML: an unexpected bonus? – Marina Konopleva and Anthony Letai. http://bloodjournal.org/content/132/10/1007.abstract?etoc

Apoptosis-Inducing Factor (AIF) in Physiology and Disease: The Tale of a Repented Natural Born Killer – Bano D, Prehn JHM. https://linkinghub.elsevier.com/retrieve/pii/S2352-3964(18)30100-2

Autophagy-dependent cell death – where, how and why a cell eats itself to death – Shani Bialik, Santosh K. Dasari and Adi Kimchi. http://jcs.biologists.org/content/131/18/jcs215152?etoc

Apoptosis and necroptosis in the liver: a matter of life and death – Robert F. Schwabe & Tom Luedd. https://www.nature.com/articles/s41575-018-0065-y

The rise of apoptosis: targeting apoptosis in hematologic malignancies – Rebecca Valentin, Stephanie Grabow and Matthew S. Davids. http://bloodjournal.org/content/132/12/1248.abstract?etoc

The induction and consequences of Influenza A virus-induced cell death – Georgia K. Atkin-Smith, Mubing Duan, Weisan Chen & Ivan K. H. Poon. https://www.nature.com/articles/s41419-018-1035-6


Comments


Ion Man: GSDMD Punches Pores to Knock Out cGAS – Rebecca Feltham, James E. Vince. https://www.cell.com/immunity/fulltext/S1074-7613(18)30389-3

Tuning Apoptosis and Neuroinflammation: TBK1 Restrains RIPK1 – Haiyang Yu, Don W. Cleveland. https://www.cell.com/cell/fulltext/S0092-8674(18)31096-1

C. elegans RAB-35: Dual roles in apoptotic cell clearance – Christian E. Rocheleau. https://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1007534

Neighbourhood deaths cause a switch in cancer subtype – Eli Pikarsky. https://www.nature.com/articles/d41586-018-06217-3

Retraction: ROS and CHOP Are Critical for Dibenzylideneacetone to Sensitize Tumor Cells to TRAIL through Induction of Death Receptors and Downregulation of Cell Survival Proteinshttp://cancerres.aacrjournals.org/content/78/17/5185

Metabolic control of ferroptosis in cancer – Michael P. Murphy. https://www.nature.com/articles/s41556-018-0209-x

ApoList – August 2018


Bcl-2 family proteins and MOMP


Mitochondrial inner membrane permeabilisation enables mtDNA release during apoptosis – Joel S Riley, Giovanni Quarato, Catherine Cloix, Jonathan Lopez,Jim O’Prey, Matthew Pearson, James Chapman, Hiromi Sesaki, Leo M Carlin, João F Passos, Ann P Wheeler, Andrew Oberst, Kevin M Ryan, Stephen WG Tait. http://emboj.embopress.org/content/early/2018/07/31/embj.201899238

Systematic mapping of BCL-2 gene dependencies in cancer reveals molecular determinants of BH3 mimetic sensitivity – Ryan S. Soderquist, Lorin Crawford, Esther Liu, Min Lu, Anika Agarwal, Grace R. Anderson, Kevin H. Lin, Peter S. Winter, Merve Cakir & Kris C. Wood. https://www.nature.com/articles/s41467-018-05815-z

Exploiting selective BCL-2 family inhibitors to dissect cell survival dependencies and define improved strategies for cancer therapy – Leverson JD, Phillips DC, Mitten MJ, Boghaert ER, Diaz D, Tahir SK, Belmont LD, Nimmer P, Xiao Y, Ma XM, Lowes KN, Kovar P, Chen J, Jin S, Smith M, Xue J, Zhang H, Oleksijew A, Magoc TJ, Vaidya KS, Albert DH2, Tarrant JM, La N, Wang L, Tao ZF, Wendt MD, Sampath D, Rosenberg SH, Tse C, Huang DC, Fairbrother WJ, Elmore SW, Souers AJ. http://stm.sciencemag.org/content/7/279/279ra40.short

TRIM17 and TRIM28 antagonistically regulate the ubiquitination and anti-apoptotic activity of BCL2A1 – Loïc Lionnard, Pauline Duc, Margs S. Brennan, Andrew J. Kueh, Martin Pal, Francesca Guardia, Barbara Mojsa, Maria-Alessandra Damiano, Stéphan Mora, Iréna Lassot, Ramya Ravichandran, Claude Cochet, Abdel Aouacheria, Patrick Ryan Potts, Marco J. Herold, Solange Desagher & Jérôme Kucharczak. https://www.nature.com/articles/s41418-018-0169-5

Restoring PUMA induction overcomes KRAS-mediated resistance to anti-EGFR antibodies in colorectal cancer – Kyle Knickelbein, Jingshan Tong, Dongshi Chen, Yi-Jun Wang, Sandra Misale, Alberto Bardelli, Jian Yu & Lin Zhang. https://www.nature.com/articles/s41388-018-0289-x

Dual inhibition of BCL-XL and MCL-1 is required to induce tumour regression in lung squamous cell carcinomas sensitive to FGFR inhibition – Clare E. Weeden, Casey Ah-Cann, Aliaksei Z. Holik, Julie Pasquet, Jean-Marc Garnier, Delphine Merino, Guillaume Lessene & Marie-Liesse Asselin-Labat. https://www.nature.com/articles/s41388-018-0268-2

RORγt limits the amount of the cytokine receptor γc through the prosurvival factor Bcl-xLin developing thymocytes – Davinna L. Ligons , SuJin Hwang, Adam T. Waickman, Joo-Young Park, Megan A. Luckey, Jung-Hyun Park. http://stke.sciencemag.org/content/11/545/eaam8939


Death receptors


Confirming a critical role for death receptor 5 and caspase-8 in apoptosis induction by endoplasmic reticulum stress – Mable Lam, David A. Lawrence, Avi Ashkenazi & Peter Walter. https://www.nature.com/articles/s41418-018-0155-y

A Single-Agent Dual-Specificity Targeting of FOLR1 and DR5 as an Effective Strategy for Ovarian Cancer – Gururaj Shivange, Karol Urbanek, Piotr Przanowski, Justin S.A. Perry, James Jones, Robert Haggart, Christina Kostka, Tejal Patki, Edward Stelow, Yuliya Petrova, Danielle Llaneza, Marty Mayo, Kodi S. Ravichandran, Charles N. Landen, Sanchita Bhatnagar, Jogender Tushir-Singh. https://www.cell.com/cancer-cell/fulltext/S1535-6108(18)30310-6

Early activation of CD95 is limited and localized to the cytotoxic synapse – María Florencia Sánchez, Fabronia Murad, Gülce S. Gülcüler Balta, Ana Martin-Villalba, Ana J. García-Sáez and Dolores C. Carrer. https://febs.onlinelibrary.wiley.com/doi/abs/10.1111/febs.14518

Coordination between Two Branches of the Unfolded Protein Response Determines Apoptotic Cell Fate – Tsun-Kai Chang, David A. Lawrence, Min Lu, Jenille Tan, Jonathan M. Harnoss, Scot A. Marsters, Peter Liu, Wendy Sandoval, Scott E. Martin, Avi Ashkenazi. https://www.cell.com/molecular-cell/fulltext/S1097-2765(18)30513-6


Caspases


HSP90 inhibition targets autophagy and induces a CASP9-dependent resistance mechanism in NSCLC – Jie Han, Leslie A. Goldstein, Wen Hou, Suman Chatterjee, Timothy F. Burns & Hannah Rabinowich. https://www.tandfonline.com/doi/full/10.1080/15548627.2018.1434471


Necroptosis / RIPK


Biallelic RIPK1 mutations in humans cause severe immunodeficiency, arthritis, and intestinal inflammation – Delphine Cuchet-Lourenço, Davide Eletto, Changxin Wu, Vincent Plagnol, Olivier Papapietro, James Curtis, Lourdes Ceron-Gutierrez, Chris M. Bacon, Scott Hackett, Badr Alsaleem, Mailis Maes, Miguel Gaspar, Ali Alisaac, Emma Goss, Eman AlIdrissi, Daniela Siegmund, Harald Wajant, Dinakantha Kumararatne, Mofareh S. AlZahrani, Peter D. Arkwright, Mario Abinun, Rainer Doffinger, Sergey Nejentsev. http://science.sciencemag.org/content/361/6404/810

Kinase domain dimerization drives RIPK3-dependent necroptosis – Saravanan Raju , Daniel M. Whalen, Meron Mengistu, Carter Swanson, John G. Quinn, Susan S. Taylor, Joshua D. Webster, Kim Newton, Andrey S. Shaw. http://stke.sciencemag.org/content/11/544/eaar2188

Neuroprotective Effects of DTIO, A Novel Analog of Nec-1, in Acute and Chronic Stages After Ischemic Stroke – Li W, Liu J, Chen JR, Zhu YM, Gao X, Ni Y, Lin B, Li H, Qiao SG, Wang C, Zhang HL, Ao GZ. https://www.sciencedirect.com/science/article/abs/pii/S0306452218305190

RIPK1–RIPK3–MLKL-Associated Necroptosis Drives Leishmania infantum Killing in Neutrophils – Laiana Arlego-Barbosa, Paloma Peixoto Fiuza, Letícia Jambeiro Borges, Fillipe dosAnjos Rolim, Mayara Borges Andrade, Nivea F Luz, Graziele Quintela-Carvalho, Jonilson Berlink Lima, Roque P. Almeida, Francis Kaming Chan, Marcelo Torres Bozza, Valeria M Borges, Deboraci Brito Prates. https://www.frontiersin.org/articles/10.3389/fimmu.2018.01818/full

Treatment with mRNA coding for the necroptosis mediator MLKL induces antitumor immunity directed against neo-epitopes – Lien Van Hoecke, Sandra Van Lint, Kenny Roose, Alexander Van Parys, Peter Vandenabeele, Johan Grooten, Jan Tavernier, Stefaan De Koker & Xavier Saelens. https://www.nature.com/articles/s41467-018-05979-8


Gasdermin D, pyroptosis


Chemical disruption of the pyroptotic pore-forming protein gasdermin D inhibits inflammatory cell death and sepsis [necrosulfonamide is a Gasdermin D inhibitor] – Joseph K. Rathkey, Junjie Zhao, Zhonghua Liu, Yinghua Chen, Jie Yang, Hannah C. Kondolf, Bryan L. Benson, Steven M. Chirieleison, Alex Y. Huang, George R. Dubyak, Tsan S. Xiao, Xiaoxia Li, Derek W. Abbott. http://immunology.sciencemag.org/content/3/26/eaat2738.full

Noncanonical inflammasome signaling elicits gasdermin D–dependent neutrophil extracellular traps – Kaiwen W. Chen, Mercedes Monteleone, Dave Boucher, Gabriel Sollberger, Divya Ramnath, Nicholas D. Condon, Jessica B. von Pein, Petr Broz, Matthew J. Sweet, Kate Schroder. http://immunology.sciencemag.org/content/3/26/eaar6676

Gasdermin D plays a vital role in the generation of neutrophil extracellular traps – Gabriel Sollberger, Axel Choidas, Garth Lawrence Burn, Peter Habenberger, Raffaella Di Lucrezia, Susanne Kordes, Sascha Menninger, Jan Eickhoff, Peter Nussbaumer, Bert Klebl, Renate Krüger, Alf Herzig, Arturo Zychlinsky. http://immunology.sciencemag.org/content/3/26/eaar6689

Interleukin-1β Maturation Triggers Its Relocation to the Plasma Membrane for Gasdermin-D-Dependent and -Independent Secretion – Mercedes Monteleone, Amanda C. Stanley, Kaiwen W. Chen, Darren L. Brown, Jelena S. Bezbradica, Jessica B. von Pein, Caroline L. Holley, Dave Boucher, Melanie R. Shakespear, Ronan Kapetanovic, Verena Rolfes, Matthew J. Sweet, Jennifer L. Stow, Kate Schroder. https://www.cell.com/cell-reports/fulltext/S2211-1247(18)31117-3


Other forms of cell death


AMPK-Mediated BECN1 Phosphorylation Promotes Ferroptosis by Directly Blocking System Xc – Activity – Xinxin Song, Shan Zhu, Pan Chen, Wen Hou, Qirong Wen, Jiao Liu, Yangchun Xie, Jinbao Liu, Daniel J. Klionsky, Guido Kroemer, Michael T. Lotze, Herbert J. Zeh, Rui Kang, Daolin Tang. https://www.cell.com/current-biology/fulltext/S0960-9822(18)30764-4

Programmed cell removal by calreticulin in tissue homeostasis and cancer – Mingye Feng, Kristopher D. Marjon, Fangfang Zhu, Rachel Weissman-Tsukamoto, Aaron Levett, Katie Sullivan, Kevin S. Kao, Maxim Markovic, Paul A. Bump, Hannah M. Jackson, Timothy S. Choi, Jing Chen, Allison M. Banuelos, Jie Liu, Phung Gip, Lei Cheng, Denong Wang & Irving L. Weissman. https://www.nature.com/articles/s41467-018-05211-7

Genomic instability in mutant p53 cancer cells upon entotic engulfment – Hannah L. Mackay, David Moore, Callum Hall, Nicolai J. Birkbak, Mariam Jamal-Hanjani, Saadia A. Karim, Vinaya M. Phatak, Lucia Piñon, Jennifer P. Morton, Charles Swanton, John Le Quesne & Patricia A. J. Muller. https://www.nature.com/articles/s41467-018-05368-1


Miscellanous


Cholesterol impairs autophagy-mediated clearance of amyloid beta while promoting its secretion – Elisabet Barbero-Camps, Vicente Roca-Agujetas, Isabel Bartolessis, Cristina de Dios, Jose C. Fernández-Checa, Montserrat Marí, Albert Morales, Tobias Hartmann & Anna Colell. https://www.tandfonline.com/doi/full/10.1080/15548627.2018.1438807#metrics-content

Activation of the apoptotic pathway during prolonged prometaphase blocks daughter cell proliferation – Yumi Uetake and Greenfield Sluder. https://www.molbiolcell.org/doi/abs/10.1091/mbc.E18-01-0026

Perforin proteostasis is regulated through its C2 domain: supra-physiological cell death mediated by T431D-perforin – Amelia J. Brennan, Ruby H. P. Law, Paul J. Conroy, Tahereh Noori, Natalya Lukoyanova, Helen Saibil, Hideo Yagita, Annette Ciccone, Sandra Verschoor, James C. Whisstock, Joseph A. Trapani & Ilia Voskoboinik. https://www.nature.com/articles/s41418-018-0057-z


Reviews / comments


RIP kinases as modulators of inflammation and immunity – Sudan He & Xiaodong Wang. https://www.nature.com/articles/s41590-018-0188-x

Ripk1 and haematopoiesis: a case for LUBAC and Ripk3 – Alessandro Annibaldi & Pascal Meier. https://www.nature.com/articles/s41418-018-0135-2

Different apoptosis pathways in Leishmania parasites – Louise Basmaciyan, Nadine Azas & Magali Casanova. https://www.nature.com/articles/s41420-018-0092-z

 

ApoList – July 2018

 


Bcl-2 family proteins


Statins enhance efficacy of venetoclax in blood cancers – J. Scott Lee, Andrew Roberts, Dennis Juarez, Thanh-Trang T. Vo, Shruti Bhatt, Lee-or Herzog, Sharmila Mallya, Richard J. Bellin, Suresh K. Agarwal, Ahmed Hamed Salem, Tu Xu, Jia Jia, Lingxiao Li, John R. Hanna, Matthew S. Davids, Angela G. Fleischman, Susan O’Brien, Lloyd T. Lam, Joel D. Leverson, Anthony Letai, Jonathan H. Schatz and David A. Fruman

http://stm.sciencemag.org/content/10/445/eaaq1240

 

Intrinsic apoptosis circumvents the functional decline of circulating platelets but does not cause the storage lesion – Irina Pleines, Marion Lebois, Pradnya Gangatirkar, Amanda E. Au, Rachael M. Lane, Katya J. Henley, Maria Kauppi, Jason Corbin, Ping Cannon, Jonathan Bernardini, Imala Alwis, Kate E. Jarman, Sarah Ellis, Donald Metcalf, Shaun P. Jackson, Simone M. Schoenwaelder, Benjamin T. Kile and Emma C. Josefsson

http://bloodjournal.org/content/132/2/197.abstract?etoc

 

DNA repair processes are critical mediators of p53-dependent tumor suppression – Ana Janic, Liz J. Valente, Matthew J. Wakefield, Leon Di Stefano, Liz Milla, Stephen Wilcox, Haoyu Yang, Lin Tai, Cassandra J. Vandenberg, Andrew J. Kueh, Shinsuke Mizutani, Margs S. Brennan, Robyn L. Schenk, Lisa M. Lindqvist, Anthony T. Papenfuss, Liam O’Connor, Andreas Strasser & Marco J. Herold

https://www.nature.com/articles/s41591-018-0043-5

 

Phosphorylation alters Bim-mediated Mcl-1 stabilization and priming – Jason E. Conage-Pough and Lawrence H. Boise

https://febs.onlinelibrary.wiley.com/doi/abs/10.1111/febs.14505

 

Low cleaved caspase-7 levels indicate unfavourable outcome across all breast cancers [and low Bcl-2] – Lindner AU, Lucantoni F, Varešlija D, Resler A, Murphy BM, Gallagher WM, Hill ADK, Young LS, Prehn JHM.

https://link.springer.com/article/10.1007%2Fs00109-018-1675-0


Death receptors


Confirming a critical role for death receptor 5 and caspase-8 in apoptosis induction by endoplasmic reticulum stress – David Lawrence, Avi Ashkenazi & Peter Walter

https://www.nature.com/articles/s41418-018-0155-y

 

Fas-L promotes the stem cell potency of adipose-derived mesenchymal cells – Inna Solodeev, Benjamin Meilik, Ilan Volovitz, Meirav Sela, Sharon Manheim, Shai Yarkoni, Dov Zipori, Eyal Gur & Nir Shani

https://www.nature.com/articles/s41419-018-0702-y

 

Hypertonicity-enforced BCL-2 addiction unleashes the cytotoxic potential of death receptors – Simon Sirtl, Gertrud Knoll, Dieu Thuy Trinh, Isabell Lang, Daniela Siegmund, Stefanie Gross, Beatrice Schuler-Thurner, Patrick Neubert, Jonathan Jantsch, Harald Wajant & Martin Ehrenschwender

https://www.nature.com/articles/s41388-018-0265-5

 

Phenotypic screening identifies a new oxazolone inhibitor of necroptosis and neuroinflammation – Sara R. Oliveira, Pedro A. Dionísio, Hugo Brito, Lídia Franco, Catarina A. B. Rodrigues, Rita C. Guedes, Carlos A. M. Afonso, Joana D. Amaral & Cecília M. P. Rodrigues

https://www.nature.com/articles/s41420-018-0067-0


Caspases and IAPs


Caspase-8 Collaborates with Caspase-11 to Drive Tissue Damage and Execution of Endotoxic Shock – Pratyusha Mandal, Yanjun Feng, John D. Lyons, Scott B. Berger, Shunsuke Otani, Alexandra DeLaney, Gregory K. Tharp, Kristal Maner-Smith, Eileen M. Burd, Michelle Schaeffer, Sandra Hoffman, Carol Capriotti, Linda Roback, Cedrick B. Young, Zhe Liang, Eric A. Ortlund, Nelson C. DiPaolo, Steven Bosinger, John Bertin, Peter J. Gough, Igor E. Brodsky, Craig M. Coopersmith, Dmitry M. Shayakhmetov, Edward S. Mocarski

https://www.cell.com/immunity/fulltext/S1074-7613(18)30293-0

 

Dimer‐specific immunoprecipitation of active caspase‐2 identifies TRAF proteins as novel activators – Alexander C Robeson, Kelly R Lindblom, Jeffrey Wojton, Sally Kornbluth and Kenkyo Matsuura

http://EMBOJ.embopress.org/content/37/14/e97072?etoc

 

Differential susceptibility of striatal, hippocampal and cortical neurons to Caspase-6 – Anastasia Noël, Libin Zhou, Bénédicte Foveau, P. Jesper Sjöström & Andréa C. LeBlanc

https://www.nature.com/articles/s41418-017-0043-x

 

Unique BIR domain sets determine inhibitor of apoptosis protein–driven cell death and NOD2 complex signal specificity – Steven M. Chirieleison, Joseph K. Rathkey, Derek W. Abbott

http://stke.sciencemag.org/content/11/539/eaao3964

 

XAF1 forms a positive feedback loop with IRF-1 to drive apoptotic stress response and suppress tumorigenesis – Seong-In Jeong, Jung-Wook Kim, Kyung-Phil Ko, Byung-Kyu Ryu, Min-Goo Lee

https://www.nature.com/articles/s41419-018-0867-4

 

Low cleaved caspase-7 levels indicate unfavourable outcome across all breast cancers – Lindner AU, Lucantoni F, Varešlija D, Resler A, Murphy BM, Gallagher WM, Hill ADK, Young LS, Prehn JHM.

https://link.springer.com/article/10.1007%2Fs00109-018-1675-0


Execution phase and post-mortem


Apoptotic Cell-Derived Extracellular Vesicles Promote Malignancy of Glioblastoma Via Intercellular Transfer of Splicing Factors – Marat S. Pavlyukov, Hai Yu, Soniya Bastola, Mutsuko Minata, Victoria O. Shender, Yeri Lee, Suojun Zhang, Jia Wang, Svetlana Komarova, Jun Wang, Shinobu Yamaguchi, Heba Allah Alsheikh, Junfeng Shi, Dongquan Chen, Ahmed Mohyeldin, Sung-Hak Kim, Yong Jae Shin, Ksenia Anufrieva, Evgeniy G. Evtushenko, Nadezhda V. Antipova, Georgij P. Arapidi, Vadim Govorun, Nikolay B. Pestov, Mikhail I. Shakhparonov, L. James Lee, Do-Hyun Nam, Ichiro Nakano

https://www.cell.com/cancer-cell/fulltext/S1535-6108(18)30226-5

 

Staurosporine-induced apoptotic water loss is cell- and attachment-specific – Michael A. Model, Nathan J. Mudrak, Priyanka S. Rana, Robert J. Clements

https://link.springer.com/article/10.1007/s10495-018-1471-x

 

Competition for Space Is Controlled by Apoptosis-Induced Change of Local Epithelial Topology – Alice Tsuboi, Shizue Ohsawa, Daiki Umetsu, Yukari Sando, Erina Kuranaga, Tatsushi Igaki, Koichi Fujimoto

https://www.cell.com/current-biology/fulltext/S0960-9822(18)30631-6


Necroptosis


NAD+ Depletion Triggers Macrophage Necroptosis, a Cell Death Pathway Exploited by Mycobacterium tuberculosis – David Pajuelo, Norberto Gonzalez-Juarbe, Uday Tak, Jim Sun, Carlos J. Orihuela, Michael Niederweis

https://www.cell.com/cell-reports/fulltext/S2211-1247(18)30952-5

 

Necroptosis promotes autophagy-dependent upregulation of DAMP and results in immunosurveillance – Sheng-Yen Lin, Sung-Yuan Hsieh, Yi-Ting Fan, Wen-Chi Wei, Pei-Wen Hsiao, Dai-Hua Tsai, Tzong-Shoon Wu & Ning-Sun Yang

https://www.tandfonline.com/doi/full/10.1080/15548627.2017.1386359

 

Activated platelets induce MLKL-driven neutrophil necroptosis and release of neutrophil extracellular traps in venous thrombosis – Daigo Nakazawa, Jyaysi Desai, Stefanie Steiger, Susanne Müller, Satish Kumar Devarapu,   Shrikant R. Mulay, Takamasa Iwakura & Hans-Joachim Anders

https://www.nature.com/articles/s41420-018-0073-2

 

Phenotypic screening identifies a new oxazolone inhibitor of necroptosis and neuroinflammation – Sara R. Oliveira, Pedro A. Dionísio, Hugo Brito, Lídia Franco, Catarina A. B. Rodrigues, Rita C. Guedes, Carlos A. M. Afonso, Joana D. Amaral & Cecília M. P. Rodrigues

https://www.nature.com/articles/s41420-018-0067-0


Miscellanous


Nano-targeted induction of dual ferroptotic mechanisms eradicates high-risk neuroblastoma – Behrouz Hassannia, Bartosz Wiernicki, Irina Ingold, Feng Qu, Simon Van Herck, Yulia Y. Tyurina, Hülya Bayır, Behnaz A. Abhari, Jose Pedro Friedmann Angeli, Sze Men Choi, Eline Meul, Karen Heyninck, Ken Declerck, Chandra Sekhar Chirumamilla, Maija Lahtela-Kakkonen, Guy Van Camp, Dmitri V. Krysko, Paul G. Ekert, Simone Fulda, Bruno G. De Geest, Marcus Conrad, Valerian E. Kagan, Wim Vanden Berghe, Peter Vandenabeele, and Tom Vanden Berghe

https://www.jci.org/articles/view/99032

 

Mechanism of membrane pore formation by human gasdermin‐D – Estefania Mulvihill, Lorenzo Sborgi, Stefania A Mari, Moritz Pfreundschuh, Sebastian Hiller and Daniel J Müller

http://EMBOJ.embopress.org/content/37/14/e98321?etoc

 

Comment on “Sterilizing immunity in the lung relies on targeting fungal apoptosis-like programmed cell death” – Abdel Aouacheria,  Kyle W. Cunningham, J. Marie Hardwick, Zdena Palková, Ted Powers, Fedor F. Severin, Libuše Váchová

http://science.sciencemag.org/content/360/6395/eaar6910

 

Response to Comment on “Sterilizing immunity in the lung relies on targeting fungal apoptosis-like programmed cell death” – Neta Shlezinger, Henriette Irmer, Sourabh Dhingra, Sarah R. Beattie, Robert A. Cramer, Gerhard H. Braus, Amir Sharon, Tobias M. Hohl

http://science.sciencemag.org/content/360/6395/eaas9457


Reviews


Programmed Cell Death in Immune Defense: Knowledge and Presumptions – David Wallach, Tae-Bong Kang

https://www.cell.com/immunity/abstract/S1074-7613(18)30301-7

 

New insights into apoptosome structure and function – Loretta Dorstyn, Christopher W. Akey & Sharad Kumar

https://www.nature.com/articles/s41418-017-0025-z

 

Do Fungi Undergo Apoptosis-Like Programmed Cell Death? – J. Marie Hardwick

http://mbio.asm.org/content/9/4/e00948-18.full


Comments / other


Gut check: dead cell samples leads to tolerant examples – Thomas H Oguin III & Jennifer Martinez

https://www.nature.com/articles/cdd201745

 

Growing a gasdermin pore in membranes of pyroptotic cells – Jingjin Ding and Feng Shao

http://EMBOJ.embopress.org/content/37/15/e100067?etoc

 

Q & A – Karen Vousden

https://www.cell.com/current-biology/fulltext/S0960-9822(18)30675-4

 

Finding clues in the p53 maze: an interview with Karen Vousden

http://dmm.biologists.org/content/11/8/dmm035675

 

Jerry Chipuk: A powerhouse for mitochondrial biology

http://jcb.rupress.org/content/early/2018/07/09/jcb.201807034

ApoList – June 2018

—————————-
Death receptors
—————————-

Regulation of a distinct activated RIPK1 intermediate bridging complex I and complex II in TNFα-mediated apoptosis
Palak Amin, Marcus Florez, Ayaz Najafov, Heling Pan, Jiefei Geng, Dimitry Ofengeim, Slawomir A. Dziedzic, Huibing Wang, Vica Jean Barrett, Yasushi Ito, Matthew J. LaVoie, and Junying Yuan
http://www.pnas.org/content/115/26/E5944?etoc=

A Drosophila Tumor Suppressor Gene Prevents Tonic TNF Signaling through Receptor N-Glycosylation
Geert de Vreede, Holly A. Morrison, Alexandra M. Houser, Ryan M. Boileau, Ditte Andersen, Julien Colombani, David Bilder
https://www.cell.com/developmental-cell/fulltext/S1534-5807(18)30369-1

TRAIL mediates and sustains constitutive NF-κB activation in LGL leukemia
Jun Yang, Francis R. LeBlanc, Shubha A. Dighe, Cait E. Hamele, Thomas L. Olson, David J. Feith and Thomas P. Loughran Jr
http://bloodjournal.org/content/131/25/2803.abstract?etoc

Monocyte chemotactic protein-induced protein-1 enhances DR5 degradation and negatively regulates DR5 activation-induced apoptosis through its deubiquitinase function
You-Take Oh, Guoqing Qian, Jiusheng Deng & Shi-Yong Sun
https://www.nature.com/articles/s41388-018-0200-9?

Dose intensification of TRAIL-inducing ONC201 inhibits metastasis and promotes intratumoral NK cell recruitment
Jessica Wagner, C. Leah Kline, Lanlan Zhou, Kerry S. Campbell, Alexander W. MacFarlane, Anthony J. Olszanski, Kathy Q. Cai, Harvey H. Hensley, Eric A. Ross, Marie D. Ralff, Andrew Zloza, Charles B. Chesson, Jenna H. Newman, Howard Kaufman, Joseph Bertino, Mark Stein, and Wafik S. El-Deiry
https://www.jci.org/articles/view/96711

CONSTRUCTION AND CHARACTERIZATION OF A NEW TRAIL SOLUBLE FORM, ACTIVE AT PICOMOLAR CONCENTRATIONS
Matias Eliseo Melendez, Renato José Silva-Oliveira, Anna Luiza Silva Almeida Vicente, Lidia Maria Rebolho Batista Arantes, Ana Carolina de Carvalho, Alberto Luis Epstein, Rui Manuel Reis, and André Lopes Carvalho
http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=view&path%5B%5D=25519&path%5B%5D=79903

Transmembrane TNF-alpha promotes chemoresistance in breast cancer cells
Zunyue Zhang, Guohong Lin, Yujing Yan, Xiang Li, Yibing Hu, Jing Wang, Bingjiao Yin, Yaqun Wu, Zhuoya Li & Xiang-Ping Yang
https://www.nature.com/articles/s41388-018-0221-4

OTULIN limits cell death and inflammation by deubiquitinating LUBAC
Klaus Heger, Katherine E. Wickliffe, Ada Ndoja, Juan Zhang, Aditya Murthy, Debra L. Dugger, Allie Maltzman, Felipe de Sousa e Melo, Jeffrey Hung, Yi Zeng, Erik Verschueren, Donald S. Kirkpatrick, Domagoj Vucic, Wyne P. Lee, Merone Roose-Girma, Robert J. Newman, Søren Warming, Yi-Chun Hsiao, László G. Kőműves, Joshua D. Webster, Kim Newton & Vishva M. Dixit
https://www.nature.com/articles/s41586-018-0256-2

Fas ligand promotes an inducible TLR-dependent model of cutaneous lupus–like inflammation
Purvi Mande, Bahar Zirak, Wei-Che Ko, Keyon Taravati, Karen L. Bride, Tia Y. Brodeur, April Deng, Karen Dresser, Zhaozhao Jiang, Rachel Ettinger, Katherine A. Fitzgerald, Michael D. Rosenblum, John E. Harris, and Ann Marshak-Rothstein
https://www.jci.org/articles/view/98219

———————————-
Caspases and IAPs
———————————-

Caspase-8 deficiency in mouse embryos triggers chronic RIPK1-dependent activation of inflammatory genes, independently of RIPK3
Tae-Bong Kang, Ju-Seong Jeong, Seung-Hoon Yang, Andrew Kovalenko & David Wallach
https://www.nature.com/articles/s41418-018-0104-9

Phosphorylation by protein kinase A disassembles the caspase-9 core
Banyuhay P. Serrano & Jeanne A. Hardy
https://www.nature.com/articles/s41418-017-0052-9

A proximity-dependent biotinylation (BioID) approach flags the p62/sequestosome-1 protein as a caspase-1 substrate
Yvan Jamilloux, Brice Lagrange, Antonia Di MIcco, Emilie Bourdonnay, Angélina Provost, Rémy Tallant, Thomas Henry and Fabio Martinon
http://www.jbc.org/content/early/2018/06/21/jbc.RA117.000435.abstract

Stimulator of interferon genes (STING) provides insect antiviral immunity by promoting Dredd caspase–mediated NF-kB activation
Xiaoting Hua, Binbin Li, Liang Song, Cuimei Hu, Xianyang Li, Dandan Wang, Ying Xiong, Ping Zhao, Huawei He, Qingyou xia and Fei Wang
http://www.jbc.org/content/early/2018/06/06/jbc.RA117.000194.abstract

Phosphorylation of XIAP at threonine 180 controls its activity in Wnt signaling
Victoria H. Ng, Brian I. Hang, Leah M. Sawyer, Leif R. Neitzel, Emily E. Crispi, Kristie L. Rose, Tessa M. Popay, Alison Zhong, Laura A. Lee, William P. Tansey, Stacey Huppert and Ethan Lee
http://jcs.biologists.org/content/131/10/jcs210575

Differentiated Macrophages Acquire a Pro-Inflammatory and Cell Death-Resistant Phenotype Due to Increasing XIAP and P38-mediated inhibition of RipK1
Dikchha Rijal, Ardeshir Ariana, Andrew Wight, Kwangsin Kim, Norah A. Alturki, Zoya Aamir, Emmanuelle Ametepe, Robert G. Korneluk, Christopher Tiedje, Manoj B Menon, Matthias Gaestel, Scott McComb and Subash Sad
http://www.jbc.org/content/early/2018/06/13/jbc.RA118.003614.abstract

SURVIVIN ANTAGONIZES CHEMOTHERAPY-INDUCED CELL DEATH OF COLORECTAL CANCER CELLS
Anke Rauch, Annemarie Carlstedt, Claudia Emmerich, Al-Hassan M. Mustafa, Anja Göder, Shirley K. Knauer,Michael Linnebacher, Thorsten Heinzel, and Oliver H. Krämer
http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=view&path%5B%5D=25600&path%5B%5D=80128

———————————-
Bcl-2 family proteins
———————————-

The ribosomal RPL10 R98S mutation drives IRES-dependent BCL-2 translation in T-ALL
Kim R. Kampen, Sergey O. Sulima, Benno Verbelen, Tiziana Girardi, Stijn Vereecke, Gianmarco Rinaldi, Jelle Verbeeck, Joyce Op de Beeck, Anne Uyttebroeck, Jules P. P. Meijerink, Anthony V. Moorman, Christine J. Harrison, Pieter Spincemaille, Jan Cools, David Cassiman, Sarah-Maria Fendt, Pieter Vermeersch & Kim De Keersmaecker
https://www.nature.com/articles/s41375-018-0176-z

BH4 domain peptides derived from Bcl-2/Bcl-XL as novel tools against acute pancreatitis
Tim Vervliet, Julia V. Gerasimenko, Pawel E. Ferdek, Monika A. Jakubowska, Ole H. Petersen, Oleg V. Gerasimenko & Geert Bultynck
https://www.nature.com/articles/s41420-018-0054-5

miR-339 Promotes Development of Stem Cell Leukemia/Lymphoma Syndrome via Downregulation of the BCL2L11 [Bim] and BAX Proapoptotic Genes
Tianxiang Hu, Yating Chong, Sumin Lu, Rebecca Wang, Haiyan Qin, Jeane Silva, Eiko Kitamura, Chang-Sheng Chang, LesleyAnn Hawthorn and John K. Cowell
http://cancerres.aacrjournals.org/content/78/13/3522

———————————-
Necroptosis
———————————-

Conformational switching of the pseudokinase domain promotes human MLKL tetramerization and cell death by necroptosis
Emma J. Petrie, Jarrod J. Sandow, Annette V. Jacobsen, Brian J. Smith, Michael D. W. Griffin, Isabelle S. Lucet, Weiwen Dai, Samuel N. Young, Maria C. Tanzer, Ahmad Wardak, Lung-Yu Liang, Angus D. Cowan, Joanne M. Hildebrand, Wilhelmus J. A. Kersten, Guillaume Lessene, John Silke, Peter E. Czabotar, Andrew I. Webb & James M. Murphy
https://www.nature.com/articles/s41467-018-04714-7

PELI1 Selectively Targets Kinase-Active RIP3 for Ubiquitylation-Dependent Proteasomal Degradation
Seung-Won Choi, Han-Hee Park, Soyeon Kim, Jee Min Chung, Hyun-Jin Noh, Sue Kyung Kim, Hyun Kyu Song, Chang-Woo Lee, Michael J. Morgan, Ho Chul Kang, You-Sun Kim
https://www.cell.com/molecular-cell/fulltext/S1097-2765(18)30390-3

MLKL Requires the Inositol Phosphate Code to Execute Necroptosis
Cole M. Dovey, Jonathan Diep, Bradley P. Clarke, Andrew T. Hale, Dan E. McNamara, Hongyan Guo, Nathaniel W. Brown Jr., Jennifer Yinuo Cao, Christy R. Grace, Peter J. Gough, John Bertin, Scott J. Dixon, Dorothea Fiedler, Edward S. Mocarski, William J. Kaiser, Tudor Moldoveanu, John D. York, Jan E. Carette
https://www.cell.com/molecular-cell/fulltext/S1097-2765(18)30360-5

Mutant p53-Expressing Cells Undergo Necroptosis via Cell Competition with the Neighboring Normal Epithelial Cells
Hirotaka Watanabe, Kojiro Ishibashi, Hiroki Mano, Sho Kitamoto, Nanami Sato, Kazuya Hoshiba, Mugihiko Kato, Fumihiko Matsuzawa, Yasuto Takeuchi, Takanobu Shirai, Susumu Ishikawa, Yuka Morioka, Toshiaki Imagawa, Kazuyasu Sakaguchi, Suguru Yonezawa, Shunsuke Kon, Yasuyuki Fujita
https://www.cell.com/cell-reports/fulltext/S2211-1247(18)30862-3

Inhibition of Programmed Necrosis Limits Infarct Size through Altered Mitochondrial and Immune Responses in the Aged Female Rat Heart.
Garvin AM1, Jackson MA2, Korzick DH
https://www.ncbi.nlm.nih.gov/pubmed/29957016/

Hyperglycemia potentiates a shift from apoptosis to RIP1-dependent necroptosis
William D. McCaig, Payal S. Patel, Sergey A. Sosunov, Nicole L. Shakerley, Tori A. Smiraglia, Miranda M. Craft, Katharine M. Walker, Matthew A. Deragon, Vadim S. Ten & Timothy J. LaRocca
https://www.nature.com/articles/s41420-018-0058-1

—————————————————————-
Pyroptosis, ferroptosis and other -osis
—————————————————————-

Mechanism of gasdermin D recognition by inflammatory caspases and their inhibition by a gasdermin D-derived peptide inhibitor
Jie Yang, Zhonghua Liu, Chuanping Wang, Rui Yang, Joseph K. Rathkey, Otis W. Pinkard, Wuxian Shi, Yinghua Chen, George R. Dubyak, Derek W. Abbott, and Tsan Sam Xiao
http://www.pnas.org/content/115/26/6792?etoc=

GSDMD is critical for autoinflammatory pathology in a mouse model of Familial Mediterranean Fever
Apurva Kanneganti, R.K. Subbarao Malireddi, Pedro H.V. Saavedra, Lieselotte Vande Walle, Hanne Van Gorp, Hiroto Kambara, Heather Tillman, Peter Vogel, Hongbo R. Luo, Ramnik J. Xavier, Hongbo Chi and Mohamed Lamkanfi
http://jem.rupress.org/content/215/6/1519?etoc

Caspase-1 inhibition prevents glial inflammasome activation and pyroptosis in models of multiple sclerosis
Brienne A. McKenzie, Manmeet K. Mamik, Leina B. Saito, Roobina Boghozian, Maria Chiara Monaco, Eugene O. Major, Jian-Qiang Lu, William G. Branton, and Christopher Power
http://www.pnas.org/content/115/26/E6065?etoc=

Increased erythrophagocytosis induces ferroptosis in red pulp macrophages in a mouse model of transfusion
Lyla A. Youssef, Abdelhadi Rebbaa, Sergey Pampou, Stuart P. Weisberg, Brent R. Stockwell, Eldad A. Hod and Steven L. Spitalnik
http://bloodjournal.org/content/131/23/2581.abstract?etoc

Neutrophils Kill Antibody-Opsonized Cancer Cells by Trogoptosis
Hanke L. Matlung, Liane Babes, Xi Wen Zhao, Michel van Houdt, Louise W. Treffers, Dieke J. van Rees, Katka Franke, Karin Schornagel, Paul Verkuijlen, Hans Janssen, Pasi Halonen, Cor Lieftink, Roderick L. Beijersbergen, Jeanette H.W. Leusen, Jaap J. Boelens, Ingrid Kuhnle, Jutte van der Werff Ten Bosch, Karl Seeger, Sergio Rutella, Daria Pagliara, Takashi Matozaki, Eiji Suzuki, Catharina Willemien Menke-van der Houven van Oordt, Robin van Bruggen, Dirk Roos, Rene A.W. van Lier, Taco W. Kuijpers, Paul Kubes, Timo K. van den Berg
https://www.cell.com/cell-reports/fulltext/S2211-1247(18)30863-5

———————————-
Miscellanous
———————————-

Local apoptotic-like mechanisms underlie complement-mediated synaptic pruning
Balázs A. Györffy, Judit Kun, György Török, Éva Bulyáki, Zsolt Borhegyi, Péter Gulyássy, Viktor Kis, Péter Szocsics, András Micsonai, János Matkó, László Drahos, Gábor Juhász, Katalin A. Kékesi, and József Kardos
http://www.pnas.org/content/115/24/6303?etoc=

—————–
Reviews
—————–

XIAP at the crossroads of cell death and inflammation
Domagoj Vucic
https://doi.org/10.18632/oncotarget.25363

Unsolved mysteries: How does lipid peroxidation cause ferroptosis?
Huizhong Feng, Brent R. Stockwell
http://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.2006203

Caspases in metabolic disease and their therapeutic potential
Claire H Wilson & Sharad Kumar
https://www.nature.com/articles/s41418-018-0111-x

Beyond Cell Death: New Functions for TNF Family Cytokines in Autoimmunity and Tumor Immunotherapy
Fei Yi, Nicholas Frazzette, Anthony C. Cruz, Christopher A. Klebanoff, Richard M. Siegel
https://www.cell.com/trends/molecular-medicine/fulltext/S1471-4914(18)30101-1

ApoList – May 2018

———————————-
Bcl-2 family proteins
———————————-

Embryogenesis and Adult Life in the Absence of Intrinsic Apoptosis Effectors BAX, BAK, and BOK
Francine F.S. Ke, Hannah K. Vanyai, Angus D. Cowan, Alex R.D. Delbridge, Lachlan Whitehead, Stephanie Grabow, Peter E. Czabotar, Anne K. Voss, Andreas Strasser
https://www.cell.com/cell/fulltext/S0092-8674(18)30567-1

Intrinsic Instability of BOK Enables Membrane Permeabilization in Apoptosis
Janet H. Zheng, Christy R. Grace, Cristina D. Guibao, Dan E. McNamara, Fabien Llambi, Yue-Ming Wang, Taosheng Chen, Tudor Moldoveanu
https://www.cell.com/cell-reports/fulltext/S2211-1247(18)30619-3

Analysis of neuronal phosphoproteome reveals PINK1 regulation of BAD function and cell death
Huida Wan, Bin Tang, Xun Liao, Qiufang Zeng, Zhuohua Zhang & Lujian Liao
https://www.nature.com/articles/s41418-017-0027-x

Disruption of the beclin 1–BCL2 autophagy regulatory complex promotes longevity in mice
Álvaro F. Fernández, Salwa Sebti, Yongjie Wei, Zhongju Zou, Mingjun Shi, Kathryn L. McMillan, Congcong He, Tabitha Ting, Yang Liu, Wei-Chung Chiang, Denise K. Marciano, Gabriele G. Schiattarella, Govind Bhagat, Orson W. Moe, Ming Chang Hu & Beth Levine
https://www.nature.com/articles/s41586-018-0162-7

BCL2 AND BCL(X)L SELECTIVE INHIBITORS DECREASE MITOCHONDRIAL ATP PRODUCTION IN BREAST CANCER CELLS AND ARE SYNTHETICALLY LETHAL WHEN COMBINED WITH 2-DEOXY-D-GLUCOSE
Federico Lucantoni, Heiko Düssmann, Irene Llorente-Folch, and Jochen H.M. Prehn
http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=view&path%5B%5D=25433&path%5B%5D=79650

INDUCTION OF APOPTOSIS AND SUPPRESSION OF TUMOR GROWTH BY NUR77-DERIVED BCL-2 CONVERTING PEPTIDE IN CHEMORESISTANT LUNG CANCER CELLS
Martin C. Pearce, John T. Gamble, Prasad R. Kopparapu, Edmond F. O’Donnell, Monica J. Mueller, Hyo Sang Jang,Julie A. Greenwood, Arnold C. Satterthwait, Roberta L. Tanguay, Xiao-Kun Zhang,  and  Siva Kumar Kolluri
http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=view&path%5B%5D=25437&path%5B%5D=79662

Loss of PUMA protects the ovarian reserve during DNA-damaging chemotherapy and preserves fertility
Quynh-Nhu Nguyen, Nadeen Zerafa, Seng H. Liew, F. Hamish Morgan, Andreas Strasser, Clare L. Scott, Jock K. Findlay, Martha Hickey & Karla J. Hutt
https://www.nature.com/articles/s41419-018-0633-7

Cotargeting BCL-2 and PI3K Induces BAX-Dependent Mitochondrial Apoptosis in AML Cells
Mohamed Rahmani, Jewel Nkwocha, Elisa Hawkins, Xinyan Pei, Rebecca E. Parker, Maciej Kmieciak, Joel D. Leverson, Deepak Sampath, Andrea Ferreira-Gonzalez and Steven Grant
http://cancerres.aacrjournals.org/content/78/11/3075

Bcl-2 Protein Targeting by the p53/p21 Complex—Letter
Liz J. Hernandez Borrero, Rahmat Sikder, Amriti Lulla, Prashanth Gokare, Paulo R. Del Valle, Xiaobing Tian, Shengliang Zhang, Philip H. Abbosh and Wafik S. El-Deiry
http://cancerres.aacrjournals.org/content/78/10/2770

Bcl-2 Protein Targeting by the p53/p21 Complex—Response
Eun Mi Kim, Jongdoo Kim and Hong-Duck Um
http://cancerres.aacrjournals.org/content/78/10/2772

——————————————
Death receptors and IAPs
——————————————

N-glycosylation of mouse TRAIL-R restrains TRAIL-induced apoptosis
Yann Estornes, Yves Dondelinger, Kathrin Weber, Inge Bruggeman, Adam Peall, Marion MacFarlane, Serge Lebecque, Peter Vandenabeele & Mathieu J. M. Bertrand
https://www.nature.com/articles/s41419-018-0544-7

Inhibitor of apoptosis proteins are required for effective fusion of autophagosomes with lysosomes
Sylwia Gradzka, Oliver S. Thomas, Oliver Kretz, Aladin Haimovici, Lazaros. Vasilikos, Wendy Wei-Lynn Wong, Georg Häcker & Ian E. Gentle
https://www.nature.com/articles/s41419-018-0508-y

——————-
Caspases
——————-

Caspase-3 Regulates YAP-Dependent Cell Proliferation and Organ Size
Yahav Yosefzon, Despina Soteriou, Alona Feldman, Lana Kostic, Elle Koren, Samara Brown, Roi Ankawa, Egor Sedov, Fabian Glaser, Yaron Fuchs
https://www.cell.com/molecular-cell/fulltext/S1097-2765(18)30315-0

Plasma Membrane Localization of Apoptotic Caspases for Non-apoptotic Functions
Alla Amcheslavsky, Shiuan Wang, Caitlin E. Fogarty, Jillian L. Lindblad, Yun Fan, Andreas Bergmann
https://www.cell.com/developmental-cell/fulltext/S1534-5807(18)30326-5

Balance between senescence and apoptosis is regulated by telomere damage–induced association between p16 and caspase-3
Shanmugam Panneer Selvam, Braden M Roth, Rose Nganga, Jisun Kim, Marion A Cooley, Kristi L. Helke, Charles D. Smith and Besim Ogretmen
http://www.jbc.org/content/early/2018/05/10/jbc.RA118.003506.abstract

Caspase-3 suppresses diethylnitrosamine-induced hepatocyte death, compensatory proliferation and hepatocarcinogenesis through inhibiting p38 activation
Na Shang, Thomas Bank, Xianzhong Ding, Peter Breslin, Jun Li, Baomin Shi & Wei Qiu
https://www.nature.com/articles/s41419-018-0617-7

Caspase-mediated cleavage of the centrosomal proteins during apoptosis
Mi Young Seo & Kunsoo Rhee
https://www.nature.com/articles/s41419-018-0632-8

Mutations in the P10 region of procaspase-8 lead to chemotherapy resistance in acute myeloid leukemia by impairing procaspase-8 dimerization
Ming Li, Xiao-Mo Wu, Ju Gao, Fen Yang, Cui-Lin Zhang, Kun Ke, Ying-Chao Wang, You-Shi Zheng, Jian-Feng Yao, Ying-Ying Guan, Xuan Chen, Juan Chen, Xiao-Long Liu & Xiao-Yu Yang
https://www.nature.com/articles/s41419-018-0511-3

———————————-
RIK1 / Necroptosis
———————————-

The Structure of the Necrosome RIPK1-RIPK3 Core, a Human Hetero-Amyloid Signaling Complex
Miguel Mompeán, Wenbo Li, Jixi Li, Ségolène Laage, Ansgar B. Siemer, Gunes Bozkurt, Hao Wu, Ann E. McDermott
https://www.cell.com/cell/fulltext/S0092-8674(18)30312-X

RIPK1 Binds MCU to Mediate Induction of Mitochondrial Ca2+ Uptake and Promotes Colorectal Oncogenesis
Fanxin Zeng, Xiao Chen, Weiyi Cui, Wei Wen, Fujian Lu, Xueting Sun, Dongwei Ma, Ye Yuan, Zezhong Li, Ning Hou, Hong Zhao, Xinyu Bi, Jianjun Zhao, Jianguo Zhou, Yan Zhang, Rui-Ping Xiao, Jianqiang Cai and Xiuqin Zhang
http://cancerres.aacrjournals.org/content/78/11/2876

Triad3a induces the degradation of early necrosome to limit RipK1-dependent cytokine production and necroptosis
Norah A. Alturki, Scott McComb, Ardeshir Ariana, Dikchha Rijal, Robert G. Korneluk, Shao-Cong Sun, Emad Alnemri & Subash Sad
https://www.nature.com/articles/s41419-018-0672-0

————————————————
Efferocytosis / immunogenicity
————————————————

NADPH oxidase activation regulates apoptotic neutrophil clearance by murine macrophages
Juhi Bagaitkar, Jing Huang, Melody Yue Zeng, Nancy K. Pech, Darlene A. Monlish, Lizet J. Perez-Zapata, Irina Miralda, Laura G. Schuettpelz and
Mary C. Dinauer
http://bloodjournal.org/content/131/21/2367.abstract?etoc

Repeated Exposure of Epithelial Cells to Apoptotic Cells Induces the Specific Selection of an Adaptive Phenotype: Implications for Tumorigenesis
Lanfei Feng, Snezana Vujicic, Michael E Dietrich, Natalia Litbarg, Suman Setty, Angelika Antoni, Joyce Rauch and Jerrold S Levine
http://www.jbc.org/content/early/2018/05/16/jbc.RA117.001290.abstract

Apoptotic cell–induced AhR activity is required for immunological tolerance and suppression of systemic lupus erythematosus in mice and humans
Rahul Shinde  Kebria Hezaveh, Marie Jo Halaby, Andreas Kloetgen, Ankur Chakravarthy, Tiago da Silva Medina, Reema Deol, Kieran P. Manion, Yuriy Baglaenko, Maria Eldh, Sara Lamorte, Drew Wallace, Sathi Babu Chodisetti, Buvana Ravishankar, Haiyun Liu, Kapil Chaudhary, David H. Munn, Aristotelis Tsirigos, Michael Madaio, Susanne Gabrielsson, Zahi Touma, Joan Wither, Daniel D. De Carvalho & Tracy L. McGaha
http://www.nature.com/articles/s41590-018-0107-1

Extrinsic Phagocyte-Dependent STING Signaling Dictates the Immunogenicity of Dying Cells
Jeonghyun Ahn, Tianli Xia, Ailem Rabasa Capote, Dillon Betancourt, Glen N. Barber
https://www.cell.com/cancer-cell/fulltext/S1535-6108(18)30132-6

C. elegans Blastomeres Clear the Corpse of the Second Polar Body by LC3-Associated Phagocytosis
Gholamreza Fazeli, Maurice Stetter, Jaime N. Lisack, Ann M. Wehman
https://www.cell.com/cell-reports/fulltext/S2211-1247(18)30587-4


———————————-
Miscellaneous

———————————-

PNPT1 Release from Mitochondria during Apoptosis Triggers Decay of Poly(A) RNAs
Xing Liu, Rui Fu4, Youdong Pan, Karla F. Meza-Sosa, Zhibin Zhang, Judy Lieberman
https://www-cell-com/cell/fulltext/S0092-8674(18)30510-5

Neutrophil extracellular traps promote macrophage pyroptosis in sepsis
Linsong Chen, Yanfeng Zhao, Dengming Lai, Peng Zhang, Yang Yang, Yuehua Li, Ke Fei, Gening Jiang & Jie Fan
https://www.nature.com/articles/s41419-018-0538-5

—————–
Reviews
—————-

Radiation-Induced Cardiovascular Toxicity: Mechanisms, Prevention, and Treatment
Johan Spetz, Javid Moslehi, Kristopher Sarosiek
https://link.springer.com/article/10.1007/s11936-018-0627-x

Regulation of lipid peroxidation and ferroptosis in diverse species
Marcus Conrad, Valerian E. Kagan, Hülya Bayir, Gabriela C. Pagnussat,  Brian Head, Maret G. Traber and Brent R. Stockwell
http://genesdev.cshlp.org/content/32/9-10/602.abstract?etoc

Apoptotic Caspases: Multiple or Mistaken Identities?
Kate McArthur, Benjamin T. Kile
https://www.cell.com/trends/cell-biology/fulltext/S0962-8924(18)30027-8

——————–
Comments
——————-

Better Together: A Hybrid Amyloid Signals Necroptosis
Dan Li, Cong Liu
https://www.cell.com/cell/fulltext/S0092-8674(18)30523-3

RIP3 is an upregulator of aerobic metabolism and the enhanced respiration by necrosomal RIP3 feeds back on necrosome to promote necroptosis
Xingfeng Qiu, Yingying Zhang & Jiahuai Han
https://www.nature.com/articles/s41418-018-0075-x

How do thymic epithelial cells die?
Reema Jain, Justine D. Mintern, Iris Tan, Grant Dewson, Andreas Strasser & Daniel H. D. Gray
https://www.nature.com/articles/s41418-018-0093-8

ApoList – April 2018

———————————-
Bcl-2 family proteins
———————————-

PUMA amplifies necroptosis signaling by activating cytosolic DNA sensors
Dongshi Chen, Jingshan Tong, Liheng Yang, Liang Wei, Donna B. Stolz, Jian Yu, Jianke Zhang, and Lin Zhang
http://www.pnas.org/content/115/15/3930?etoc=

Increased A20-E3 ubiquitin ligase interactions in bid-deficient glia attenuate TLR3- and TLR4-induced inflammation
Sinéad Kinsella, Michael Fichtner, Orla Watters, Hans-Georg König and Jochen H. M. Prehn
https://www.readcube.com/articles/10.1186/s12974-018-1143-3

The oncogenic tyrosine kinase Lyn impairs the pro-apoptotic function of Bim
Lazaro E. Aira, Elodie Villa, Pascal Colosetti, Parvati Gamas, Laurie Signetti, Sandrine Obba, Emma Proics, Fabien Gautier, Béatrice Bailly-Maitre, Arnaud Jacquel, Guillaume Robert, Frédéric Luciano, Philippe P. Juin, Jean-Ehrland Ricci, Patrick Auberger & Sandrine Marchetti
https://www.nature.com/articles/s41388-017-0112-0

Bax retrotranslocation potentiates Bcl-xL’s antiapoptotic activity and is essential for switch-like transitions between MOMP competency and resistance
Annika Hantusch, Kushal K. Das, Ana J. García-Sáez, Thomas Brunner & Markus Rehm
https://www.nature.com/articles/s41419-018-0464-6

Folding and binding pathways of BH3-only proteins are encoded within their intrinsically disordered sequence, not templated by partner proteins
Michael D. Crabtree, Carolina A. T. F. Mendonça, Quenton R. Bubb and Jane Clarke
http://www.jbc.org/content/early/2018/05/01/jbc.RA118.002791.abstract

Requirement of GSK-3 for PUMA induction upon loss of pro-survival PI3K signaling
Florian Schubert, Juliane Rapp, Prisca Brauns-Schubert, Lisa Schlicher, Kerstin Stock, Manuela Wissler, Martina Weiß, Céline Charvet, Christoph Borner & Ulrich Maurer
https://www.nature.com/articles/s41419-018-0502-4

Venetoclax for patients with chronic lymphocytic leukemia who progressed during or after idelalisib therapy
Steven Coutre, Michael Choi, Richard R. Furman, Herbert Eradat, Leonard Heffner, Jeffrey A. Jones, Brenda Chyla, Lang Zhou, Suresh Agarwal, Tina Waskiewicz, Maria Verdugo, Rod A. Humerickhouse, Jalaja Potluri, William G. Wierda and Matthew S. Davids
http://bloodjournal.org/content/131/15/1704.abstract?etoc

SELECTIVE INHIBITION OF BCL-2 IS A PROMISING TARGET IN PATIENTS WITH HIGH-RISK MYELODYSPLASTIC SYNDROMES AND ADVERSE MUTATIONAL PROFILE
Veronika Reidel, Johanna Kauschinger, Richard T. Hauch, Catharina Müller-Thomas, Niroshan Nadarajah, Rainer Burgkart, Burkhard Schmidt, Dirk Hempel, Anne Jacob, Julia Slotta-Huspenina, Ulrike Höckendorf, Christian Peschel, Wolfgang Kern, Torsten Haferlach, Katharina S. Götze, Stefanie Jilg, and Philipp J. Jost
http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=view&path%5B%5D=24775&path%5B%5D=77697

Targeting PLK1 overcomes T-DM1 resistance via CDK1-dependent phosphorylation and inactivation of Bcl-2/xL in HER2-positive breast cancer
Özge Saatci, Simone Borgoni, Özge Akbulut, Selvi Durmus, Umar Raza , Erol Eyüpoğlu , Can Alkan , Aytekin Akyol , Özgür Kütük, Stefan Wiemann & Özgür Şahin
http://www.nature.com/articles/s41388-017-0108-9

Differential role of FL-BID and t-BID during verotoxin-1-induced apoptosis in Burkitt’s lymphoma cells
Justine Debernardi, Emilie Hollville, Marc Lipinski, Joëlle Wiels & Aude Robert
https://www.nature.com/articles/s41388-018-0123-5

—————————–
Death receptors
—————————–

LUBAC is essential for embryogenesis by preventing cell death and enabling haematopoiesis
Nieves Peltzer, Maurice Darding, Antonella Montinaro, Peter Draber, Helena Draberova, Sebastian Kupka, Eva Rieser, Amanda Fisher, Ciaran Hutchinson, Lucia Taraborrelli, Torsten Hartwig, Elodie Lafont, Tobias L. Haas, Yutaka Shimizu, Charlotta Böiers, Aida Sarr, James Rickard, Silvia Alvarez-Diaz, Michael T. Ashworth, Allison Beal, Tariq Enver, John Bertin, William Kaiser, Andreas Strasser, John Silke, Philippe Bouillet & Henning Walczak
https://www.nature.com/articles/s41586-018-0064-8

Mind Bomb Regulates Cell Death during TNF Signaling by Suppressing RIPK1’s Cytotoxic Potential
Rebecca Feltham, Kunzah Jamal, Tencho Tenev, Gianmaria Liccardi, Isabel Jaco, Celia Monteiro Domingues, Otto Morris, Sidonie Wicky John, Alessandro Annibaldi, Marcella Widya, Conor J. Kearney, Danielle Clancy, Paul R. Elliott, Timo Glatter, Qi Qiao, Andrew J. Thompson, Alexey Nesvizhskii, Alexander Schmidt, David Komander, Hao Wu, Seamus Martin, Pascal Meier
https://www.cell.com/cell-reports/fulltext/S2211-1247(18)30399-1

S-Nitrosylation of cIAP1 Switches Cancer Cell Fate from TNFα/TNFR1-Mediated Cell Survival to Cell Death
Sabrina Romagny, Sarra Bouaouiche, Géraldine Lucchi, Patrick Ducoroy, Jean B. Bertoldo, Hernan Terenzi, Ali Bettaieb and Stéphanie Plenchette
http://cancerres.aacrjournals.org/content/78/8/1948

Small tumor necrosis factor receptor biologics inhibit the tumor necrosis factor-p38 signalling axis and inflammation
Violet R. Mukaro, Alex Quach, Michelle E. Gahan, Bernadette Boog, Zhi H. Huang, Xiuhui Gao, Carol Haddad, Suresh Mahalingam, Charles S. Hii & Antonio Ferrante
https://www.nature.com/articles/s41467-018-03640-y

Cytokeratin 8/18 protects breast cancer cell lines from TRAIL-induced apoptosis
William P. Bozza, Yaqin Zhang,  and  Baolin Zhang
http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=view&path[]=25297&path[]=79257

The novel TRAIL-receptor agonist APG350 exerts superior therapeutic activity in pancreatic cancer cells
Karen Legler, Charlotte Hauser, Jan-Hendrik Egberts, Anna Willms, Carola Heneweer, Susann Boretius, Christoph Röcken, Claus-Christian Glüer, Thomas Becker, Michael Kluge, Oliver Hill, Christian Gieffers, Harald Fricke, Holger Kalthoff, Johannes Lemke & Anna Trauzold
https://www.nature.com/articles/s41419-018-0478-0?

——————-
Caspases
——————-

Caspase-9 CARD : core domain interactions require a properly formed active site
Kristen L. Huber, Banyuhay P. Serrano and Jeanne A. Hardy
http://www.biochemj.org/content/475/6/1177?etoc

Suppressed translation as a mechanism of initiation of CASP8 (caspase 8)-dependent apoptosis in autophagy-deficient NSCLC cells under nutrient limitation
Giulia Allavena, Francesca Cuomo, Georg Baumgartner, Tadeja Bele, Alexander Yarar Sellgren, Kyaw Soe Oo, Kaylee Johnson, Vladimir Gogvadze, Boris Zhivotovsky & Vitaliy O Kaminskyy
https://www.tandfonline.com/doi/full/10.1080/15548627.2017.1405192

——————————
Necroptosis
———————————-

TWEAK and RIPK1 mediate a second wave of cell death during AKI
Diego Martin-Sanchez, Miguel Fontecha-Barriuso, Susana Carrasco, Maria Dolores Sanchez-Niño, Anne von Mässenhausen, Andreas Linkermann, Pablo Cannata-Ortiz, Marta Ruiz-Ortega, Jesus Egido, Alberto Ortiz, and Ana Belen Sanz
http://www.pnas.org/content/115/16/4182

Phenytoin inhibits necroptosis
Anne von Mässenhausen, Wulf Tonnus, Nina Himmerkus, Simon Parmentier, Danish Saleh, Diego Rodriguez, Jiraporn Ousingsawat, Rosalind L. Ang, Joel M. Weinberg, Ana B. Sanz, Alberto Ortiz, Adrian Zierleyn, Jan Ulrich Becker, Blandine Baratte, Nathalie Desban, Stéphane Bach, Ina Maria Schiessl, Shoko Nogusa, Siddharth Balachandran, Hans Joachim Anders, Adrian T. Ting, Markus Bleich, Alexei Degterev, Karl Kunzelmann, Stefan R. Bornstein, Douglas R. Green, Christian Hugo & Andreas Linkermann
https://www.nature.com/articles/s41419-018-0394-3

Proteasome inhibition blocks necroptosis by attenuating death complex aggregation
Mohammad Ali & Edward S. Mocarski
https://www.nature.com/articles/s41419-018-0371-x

RIP kinase 1–dependent endothelial necroptosis underlies systemic inflammatory response syndrome
Matija Zelic, Justine E. Roderick, Joanne A. O’Donnell, Jesse Lehman, Sung Eun Lim, Harish P. Janardhan, Chinmay M. Trivedi, Manolis Pasparakis, and Michelle A. Kelliher
https://www.jci.org/articles/view/96147

Necroptosis promotes cell-autonomous activation of proinflammatory cytokine gene expression
Kezhou Zhu, Wei Liang, Zaijun Ma, Daichao Xu, Shuangyi Cao, Xiaojuan Lu, Nan Liu, Bing Shan, Lihui Qian & Junying Yuanhttps://www.nature.com/articles/s41419-018-0524-y

Lysosomal damage after spinal cord injury causes accumulation of RIPK1 and RIPK3 proteins and potentiation of necroptosis
Shuo Liu, Yun Li, Harry M. C. Choi, Chinmoy Sarkar, Eugene Y. Koh Junfang Wu & Marta M. Lipinski
https://www.nature.com/articles/s41419-018-0469-1

———————————-
Miscellanous
———————————-

Oxidative stress alters mitochondrial bioenergetics and modifies pancreatic cell death independently of cyclophilin D, resulting in an apoptosis-to-necrosis shift
Jane A Armstrong, Nicole J Cash, Yulin Ouyang, Jack C Morton, Michael Chvanov, Diane Latawiec, Muhammad Awais, Alexei V Tepikin, Robert Sutton and David N Criddle
http://www.jbc.org/content/early/2018/04/06/jbc.RA118.003200.abstract

Cytochrome c speeds up caspase cascade activation by blocking 14-3-3ε-dependent Apaf-1 inhibition
Carlos A. Elena-Real, Antonio Díaz-Quintana, Katiuska González-Arzola, Adrián Velázquez-Campoy, Mar Orzáez, Abelardo López-Rivas, Sergio Gil-Caballero, Miguel Á. De la Rosa & Irene Díaz-Moreno
https://www.nature.com/articles/s41419-018-0408-1

—————–
Reviews
—————-

Apoptosis-Inducing Factor (AIF) in Physiology and Disease: The Tale of a Repented Natural Born Killer
Daniele Bano,  Jochen H.M. Prehn
http://www.ebiomedicine.com/article/S2352-3964(18)30100-2/fulltext

Neuronal Cell Death
Michael Fricker, Aviva M. Tolkovsky, Vilmante Borutaite , Michael Coleman, and Guy C. Brown
https://www.physiology.org/doi/abs/10.1152/physrev.00011.2017

Regulation of TNF-Related Apoptosis-Inducing Ligand Signaling by Glycosylation
Olivier Micheau
http://www.mdpi.com/1422-0067/19/3/715

———————————
Comments / other
———————————

Caspase substrates won’t be defined by a four-letter code
Paul J. Baker and Seth L. Masters
http://www.jbc.org/content/293/18/7068.abstract.html

BAX and BAK at the Gates of Innate Immunity
Lorenzo Galluzzi, Claire Vanpouille-Box
https://www.cell.com/trends/cell-biology/fulltext/S0962-8924(18)30034-5

Evolution of an allosteric “off switch” in apoptotic caspases
Andrew B. Herr
http://www.jbc.org/content/293/15/5462.abstract.html

Venetoclax after idelalisib: relevant progress for CLL
Francesc Bosch and Michael Hallek
http://bloodjournal.org/content/131/15/1632?etoc

Selenium and iron, two elemental rivals in the ferroptotic death process
Irina Ingold and Marcus Conrad
http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=download&path%5B%5D=25295&path%5B%5D=79251

Obituary
John Sulston (1942–2018)
Martin Chalfie
https://www.cell.com/cell/fulltext/S0092-8674(18)30517-8

ApoList – March 2018

————————————-
Bcl-2 family proteins
————————————-

Mcl-1 and Bcl-xL sequestration of Bak confers differential resistance to BH3-only proteins
Colin Hockings, Amber E. Alsop, Stephanie C. Fennell, Erinna F. Lee, W. Douglas Fairlie, Grant Dewson & Ruth M. Kluck
https://www.nature.com/articles/s41418-017-0010-6

Breast Cancer Targeting through Inhibition of the Endoplasmic Reticulum-Based Apoptosis Regulator Nrh/BCL2L10
Adrien Nougarede, Nikolay Popgeorgiev, Loay Kassem, Soleilmane Omarjee, Stephane Borel, Ivan Mikaelian, Jonathan Lopez, Rudy Gadet, Olivier Marcillat, Isabelle Treilleux, Bruno O. Villoutreix, Ruth Rimokh and Germain Gillet
http://cancerres.aacrjournals.org/content/78/6/1404

Anti-apoptotic A1 is not essential for lymphoma development in Eµ-Myc mice but helps sustain transplanted Eµ-Myc tumour cells
Mark Mensink, Natasha S. Anstee, Mikara Robati, Robyn L. Schenk, Marco J. Herold, Suzanne Cory & Cassandra J. Vandenberg
https://www.nature.com/articles/s41418-017-0045-8

Transmembrane E3 ligase RNF183 mediates ER stress-induced apoptosis by degrading Bcl-xL
Yanfang Wu, Xia Li, Junying Jia, Yanpeng Zhang, Jing Li, Zhengmao Zhu, Huaqing Wang, Jie Tang, and Junjie Hu
http://www.pnas.org/content/115/12/E2762

ANTIAPOPTOTIC BCL-2 PROTEINS DETERMINE SORAFENIB/REGORAFENIB RESISTANCE AND BH3-MIMETIC EFFICACY IN HEPATOCELLULAR CARCINOMA
Anna Tutusaus, Milica Stefanovic, Loreto Boix, Blanca Cucarull, Aynara Zamora, Laura Blasco, Pablo García de Frutos, Maria Reig, Jose C. Fernandez-Checa, Montserrat Marí, Anna Colell, Jordi Bruix,  and  Albert Morales
http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=view&path%5B%5D=24673&path%5B%5D=77402

BCL-XL AS A POOR PROGNOSTIC BIOMARKER AND PREDICTOR OF RESPONSE TO ADJUVANT CHEMOTHERAPY SPECIFICALLY IN BRAF-MUTANT STAGE II AND III COLON CANCER
Philip D. Dunne, Helen G. Coleman, Peter Bankhead, Matthew Alderdice, Ronan T. Gray, Stephen McQuaid,Victoria Bingham, Maurice B. Loughrey, Jacqueline A. James, Amy M. B. McCorry, Alan Gilmore, Caitriona Holohan,Dirk Klingbiel, Sabine Tejpar, Patrick G. Johnston, Darragh G. McArt, Federica Di Nicolantonio, Daniel B. Longley, and  Mark Lawler
http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=view&path%5B%5D=24481&path%5B%5D=76870

———————————
Death receptors
———————————

Fas Promotes T Helper 17 Cell Differentiation and Inhibits T Helper 1 Cell Development by Binding and Sequestering Transcription Factor STAT1
Gerd Meyer zu Horste, Dariusz Przybylski, Markus A. Schramm, Chao Wang, Alexandra Schnell, Youjin Lee, Raymond Sobel, Aviv Regev, Vijay K. Kuchroo
http://www.cell.com/immunity/fulltext/S1074-7613(18)30084-0

The Fas/Fap-1/Cav-1 complex regulates IL-1RA secretion in mesenchymal stem cells to accelerate wound healing
Xiaoxing Kou , Xingtian Xu, Chider Chen, Maria Laura Sanmillan, Tao Cai, Yanheng Zhou, Claudio Giraudo, Anh Le, Songtao Shi
http://stm.sciencemag.org/content/10/432/eaai8524

DDIAS suppresses TRAIL-mediated apoptosis by inhibiting DISC formation and destabilizing caspase-8 in cancer cells
Joo-Young Im, Bo-Kyung Kim, Ji-Young Lee, Seung-Ho Park, Hyun Seung BanKyeong Eun Jung &
Misun Won
https://www.nature.com/articles/s41388-017-0025-y

Glycogen synthase kinase-3ß inhibition promotes lysosome-dependent degradation of c-FLIPL in hepatocellular carcinoma
Na Zhang, Xiaojia Liu, Lu Liu, Zhesong Deng, Qingxuan Zeng, Weiqiang Pang, Yang Liu, Danqing Song & Hongbin Deng
https://www.nature.com/articles/s41419-018-0309-3

Glutamine metabolism regulates FLIP expression and sensitivity to TRAIL in triple-negative breast cancer cells
Marta Mauro-Lizcano & Abelardo López-Rivas
https://www.nature.com/articles/s41419-018-0263-0

STAT5 INHIBITION INDUCES TRAIL/DR4 DEPENDENT APOPTOSIS IN PERIPHERAL T-CELL LYMPHOMA
Haley M. Simpson, Aki Furusawa, Kavitha Sadashivaiah, Curt I. Civin, and Arnob Banerjee
http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=view&path%5B%5D=24698&path%5B%5D=77475

INTERFERON BETA INDUCES APOPTOSIS IN NASOPHARYNGEAL CARCINOMA CELLS VIA THE TRAIL-SIGNALING PATHWAY
Anna Makowska, Lora Wahab, Till Braunschweig, Nikiforos-Ioannis Kapetanakis, Christian Vokuhl, Bernd Denecke,Lian Shen, Pierre Busson, and Udo Kontny
http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=view&path%5B%5D=24479&path%5B%5D=76864

——————————————————-
Caspases, metacaspases, IAPs
——————————————————-

The anti-caspase inhibitor Q-VD-OPH prevents AIDS disease progression in SIV-infected rhesus macaques
Mireille Laforge, Ricardo Silvestre, Vasco Rodrigues, Julie Garibal, Laure Campillo-Gimenez, Shahul Mouhamad, Valérie Monceaux, Marie-Christine Cumont, Henintsoa Rabezanahary, Alain Pruvost, Anabela Cordeiro-da-Silva, Bruno Hurtrel, Guido Silvestri, Anna Senik, and Jérôme Estaquier
https://www.jci.org/articles/view/95127

DNA‐damage inducible protein 1 is a conserved metacaspase substrate that is cleaved and further destabilized in yeast under specific metabolic conditions
León A. Bouvier, Gabriela T. Niemirowicz, Emir Salas‐Sarduy, Juan José Cazzulo, Vanina E. Alvarez
https://febs.onlinelibrary.wiley.com/toc/17424658/285/6?campaign=woletoc

Effect of phosphorylation and single nucleotide polymorphisms on caspase substrates processing
Sonu Kumar & Piotr Cieplak
https://link.springer.com/article/10.1007/s10495-018-1442-2?wt_mc=alerts.TOCjournals

XIAP Regulation by MNK Links MAPK and NFκB Signaling to Determine an Aggressive Breast Cancer Phenotype
Myron K. Evans, Michael C. Brown, Joseph Geradts, Xuhui Bao, Timothy J. Robinson, Mohit Kumar Jolly, Peter B. Vermeulen, Gregory M. Palmer, Matthias Gromeier, Herbert Levine, Michael A. Morse, Steven J. Van Laere and Gayathri R. Devi
http://cancerres.aacrjournals.org/content/78/7/1726

——————————-
Immunogenicity
——————————-

Autophagy induced during apoptosis degrades mitochondria and inhibits type I interferon secretion
Lisa M. Lindqvist, Daniel Frank, Kate McArthur, Toby A. Dite, Michael Lazarou, Jonathan S. Oakhill, Benjamin T. Kile & David L. Vaux
https://www.nature.com/articles/s41418-017-0017-z

————————————-
Necroptosis, RIPK1
————————————-

CRISPR whole-genome screening identifies new necroptosis regulators and RIPK1 alternative splicing
Marinella G. Callow, Colin Watanabe, Katherine E. Wickliffe, Russell Bainer, Sarah Kummerfield, Julie Weng, Trinna Cuellar, Vasantharajan Janakiraman, Honglin Chen, Ben Chih, Yuxin Liang, Benjamin Haley, Kim Newton & Michael R. Costa
https://www.nature.com/articles/s41419-018-0301-y

TAK1 restricts spontaneous NLRP3 activation and cell death to control myeloid proliferation
R.K. Subbarao Malireddi, Prajwal Gurung, Jayadev Mavuluri, Tejasvi Krishna Dasari, Jeffery M. Klco, Hongbo Chi, Thirumala-Devi Kanneganti
http://jem.rupress.org/content/215/4/1023?etoc

————————————————————-
Other forms of regulated necrosis
————————————————————-

Determination of the subcellular localization and mechanism of action of ferrostatins in suppressing ferroptosis
Michael M. Gaschler, Fanghao Hu, Huizhong Feng, Andreas Linkermann, Wei Min, and Brent R. Stockwell
https://pubs.acs.org/doi/10.1021/acschembio.8b00199

Gasdermin D Exerts Anti-inflammatory Effects by Promoting Neutrophil Death
Hiroto Kambara, Fei Liu, Xiaoyu Zhang, Peng Liu, Besnik Bajrami, Yan Teng, Li Zhao, Shiyi Zhou, Hongbo Yu, Weidong Zhou, Leslie E. Silberstein, Tao Cheng, Mingzhe Han, Yuanfu Xu, Hongbo R. Luo
http://www.cell.com/cell-reports/fulltext/S2211-1247(18)30261-4

Contribution of TMEM16F to pyroptotic cell death
Jiraporn Ousingsawat, Podchanart Wanitchakool, Rainer Schreiber & Karl Kunzelmann
https://www.nature.com/articles/s41419-018-0373-8

Loss of Cdk5 in breast cancer cells promotes ROS-mediated cell death through dysregulation of the mitochondrial permeability transition pore
Saranya Navaneetha Krishnan, Jesusa L. Rosales & Ki-Young Lee
https://www.nature.com/articles/s41388-017-0103-1

—————————
Miscellaneous
—————————

Diminished apoptotic priming and ATM signalling confer a survival advantage onto aged haematopoietic stem cells in response to DNA damage
Paula Gutierrez-Martinez, Leah Hogdal, Manavi Nagai, Miriama Kruta, Rumani Singh, Kristopher Sarosiek, Andre Nussenzweig, Isabel Beerman, Anthony Letai & Derrick J. Rossi
https://www.nature.com/articles/s41556-018-0054-y

Autophagy Inhibition Mediates Apoptosis Sensitization in Cancer Therapy by Relieving FOXO3a Turnover
Brent E. Fitzwalter, Christina G. Towers, Kelly D. Sullivan, Zdenek Andrysik, Maria Hoh, Michael Ludwig, Jim O’Prey, Kevin M. Ryan, Joaquin M. Espinosa, Michael J. Morgan, Andrew Thorburn
http://www.cell.com/developmental-cell/fulltext/S1534-5807(18)30109-6

———————————-
Reviews / comments
———————————-

Perturbing mitosis for anti‐cancer therapy: is cell death the only answer?
Manuel Haschka, Gerlinde Karbon, Luca L Fava and Andreas Villunger
http://EMBOr.embopress.org/content/19/3/e45440?etoc

Nonapoptotic functions of Fas/CD95 in the immune response
Jean-Philippe Guégan and Patrick Legembre
http://onlinelibrary.wiley.com/doi/10.1111/febs.14292/abstract

Necroptosis in development and diseases
Bing Shan, Heling Pan, Ayaz Najafov and Junying Yuan
http://genesdev.cshlp.org/content/32/5-6/327.abstract?etoc

All about the caspase-dependent functions without cell death
Luis Alberto Baena-Lopez
https://www.sciencedirect.com/science/article/pii/S1084952118300028?via%3Dihub

FOXO3a Provides a Quickstep from Autophagy Inhibition to Apoptosis in Cancer Therapy
Patrice Codogno, Etienne Morel
http://www.cell.com/developmental-cell/fulltext/S1534-5807(18)30151-5

ApoList – February 2018

 
 
————————————
Bcl-2 family proteins
————————————
 
BAK/BAX macropores facilitate mitochondrial herniation and mtDNA efflux during apoptosis
Kate McArthur, Lachlan W. Whitehead, John M. Heddleston, Lucy Li, Benjamin S. Padman, Viola Oorschot, Niall D. Geoghegan, Stephane Chappaz, Sophia Davidson, Hui San Chin, Rachael M. Lane, Marija Dramicanin, Tahnee L. Saunders, Canny Sugiana, Romina Lessene, Laura D. Osellame, Teng-Leong Chew, Grant Dewson, Michael Lazarou, Georg Ramm, Guillaume Lessene, Michael T. Ryan, Kelly L. Rogers, Mark F. van Delft, Benjamin T. Kile
 
Dynamic Regulation of Long-Chain Fatty Acid Oxidation by a Noncanonical Interaction between the MCL-1 BH3 Helix and VLCAD
Silvia Escudero, Elma Zaganjor, Susan Lee, Christopher P. Mill, Ann M. Morgan, Emily B. Crawford, Jiahao Chen, Thomas E. Wales, Rida Mourtada, James Luccarelli, Gregory H. Bird, Ulrich Steidl, John R. Engen, Marcia C. Haigis, Joseph T. Opferman, Loren D. Walensky
 
Targeting CDK6 and BCL2 Exploits the “MYB Addiction” of Ph+ Acute Lymphoblastic Leukemia
Marco De Dominici, Patrizia Porazzi, Angela Rachele Soliera, Samanta A. Mariani, Sankar Addya, Paolo Fortina, Luke F. Peterson, Orietta Spinelli, Alessandro Rambaldi, Giovanni Martinelli, Anna Ferrari, Ilaria Iacobucci and Bruno Calabretta
 
B cell lymphoma 2 (Bcl-2) residues essential for Bcl-2’s apoptosis-inducing interaction with Nur77/Nor-1 orphan steroid receptors
Karl L. Banta, Xinyue Wang, Phani Das and Astar Winoto
 
Downregulation of MCL-1 and upregulation of PUMA using mTOR inhibitors enhance antitumor efficacy of BH3 mimetics in triple-negative breast cancer
Haolong Li, Lei Liu, Haocai Chang, Zhengzhi Zou & Da Xing
 
The BAX/BAK-like protein BOK is a prognostic marker in colorectal cancer
Steven Carberry, Beatrice D’Orsi, Naser Monsefi, Manuela Salvucci, Orna Bacon, Joanna Fay, Markus Rehm, Deborah McNamara, Elaine W. Kay & Jochen M. H. Prehn
 
MCL-1 is a prognostic indicator and drug target in breast cancer
Kirsteen J. Campbell, Sandeep Dhayade, Nicola Ferrari, Andrew H. Sims, Emma Johnson, Susan M. Mason, Ashley Dickson, Kevin M. Ryan, Gabriela Kalna, Joanne Edwards, Stephen W. G. Tait & Karen Blyth
 
Grouper Iridovirus GIV66 is a Bcl-2 protein that inhibits apoptosis by exclusively sequestering Bim
Suresh Banjara, Jiahao Mao, Timothy M. Ryan, Sofia Caria and Marc Kvansakul
 
 
—————————
Caspases
—————————
 
Caspase-1 self-cleavage is an intrinsic mechanism to terminate inflammasome activity
Dave Boucher, Mercedes Monteleone, Rebecca C. Coll, Kaiwen W. Chen, Connie M. Ross, Jessica L. Teo, Guillermo A. Gomez, Caroline L. Holley, Damien Bierschenk, Katryn J. Stacey, Alpha S. Yap, Jelena S. Bezbradica, Kate Schroder
 
Extensive peptide and natural protein substrate screens reveal that mouse caspase-11 has much narrower substrate specificity than caspase-1
Monica L Gonzalez Ramirez, Marcin Poreba, Scott J Snipas, Katarzyna Groborz, Marcin Drag and Guy S Salvesen
 
Modifications to a common phosphorylation network provide individualized control in caspases
Melvin E Thomas, Robert Grinshpon, Paul Swartz and A Clay Clark
 
A caspase-2-RFXANK interaction and its implication for MHC class II expression
Jeremy Forsberg, Xinge Li, Birce Akpinar, Roger Salvatori, Martin Ott, Boris Zhivotovsky & Magnus Olsson
 
Glycolysis promotes caspase-3 activation in lipid rafts in T cells
Michael A. Secinaro, Karen A. Fortner, Oliver Dienz, Angela Logan, Michael P. Murphy, Vikas Anathy, Jonathan E. Boyson & Ralph C. Budd
 
ATP-COMPETITIVE PLK1 INHIBITORS INDUCE CASPASE 3-MEDIATED PLK1 CLEAVAGE AND ACTIVATION IN HEMATOPOIETIC CELL LINES
Maeva Dufies, Damien Ambrosetti, Sonia Boulakirba, Anne Calleja, Coline Savy, Nathan Furstoss, Marwa Zerhouni, Julien Parola, Lazaro Aira-Diaz, Sandrine Marchetti, Francois Orange, Sandra Lacas-Gervais, Frederic Luciano, Arnaud Jacquel, Guillaume Robert, Gilles Pagès, and Patrick Auberger
 
Rare mutations inapoptosis related genes APAF1, CASP9, and CASP3 contribute to human neural tube defects
Xiangyu Zhou, Weijia Zeng, Huili Li, Haitao Chen, Gang Wei, Xueyan Yang, Ting Zhang & Hongyan Wang
 
 
———————————————
Death receptors and FLIP
———————————————
 
Neutralization of CD95 ligand protects the liver against ischemia-reperfusion injury and prevents acute liver failure Mohammed Al-Saeedi, Niels Steinebrunner, Hassan Kudsi, Niels Halama, Carolin Mogler, Markus W. Büchler, Peter H. Krammer, Peter Schemmer & Martina Müller
 
c-FLIP is a target of the E3 ligase deltex1 in gastric cancer
Tzu-Sheng Hsu, Shu-Ting Mo, Ping-Ning Hsu & Ming-Zong Lai
 
Impairment of Fas-ligand–caveolin-1 interaction inhibits Fas-ligand translocation to rafts and Fas-ligand-induced cell death
Xenia A. Glukhova, Julia A. Trizna, Olga V. Proussakova, Vladimir Gogvadze & Igor P. Beletsky
 
 
—————-
IAPs
—————-
 
Disruption of XIAP-RIP2 Association Blocks NOD2-Mediated Inflammatory Signaling
Tatiana Goncharov, Stefanie Hedayati, Melinda M. Mulvihill, Anita Izrael-Tomasevic, Kerry Zobel, Surinder Jeet, Anna V. Fedorova, Celine Eidenschenk, Jason deVoss, Kebing Yu, Andrey S. Shaw, Donald S. Kirkpatrick, Wayne J. Fairbrother, Kurt Deshayes, Domagoj Vucic
 
Ubiquitin-Mediated Regulation of RIPK1 Kinase Activity Independent of IKK and MK2
Alessandro Annibaldi, Sidonie Wicky John, Tom Vanden Berghe, Kirby N. Swatek, Jianbin Ruan, Gianmaria Liccardi, Katiuscia Bianchi, Paul R. Elliott, Sze Men Choi, Samya Van Coillie, John Bertin, Hao Wu, David Komander, Peter Vandenabeele, John Silke, Pascal Meier
 
The IAP family member BRUCE regulates autophagosome–lysosome fusion
Petra Ebner, Isabella Poetsch, Luiza Deszcz, Thomas Hoffmann, Johannes Zuber & Fumiyo Ikeda
 
IAPs Regulate Distinct Innate Immune Pathways to Co-ordinate the Response to Bacterial Peptidoglycans
Che A. Stafford, Kate E. Lawlor, Valentin J. Heim, Aleksandra Bankovacki, Jonathan P. Bernardini, John Silke, Ueli Nachbur
 
 
———————–
Necroptosis
———————–
 
Death-domain dimerization-mediated activation of RIPK1 controls necroptosis and RIPK1-dependent apoptosis
Huyan Meng, Zhen Liu, Xingyan Li, Huibing Wang, Taijie Jin, Guowei Wu, Bing Shan, Dana E. Christofferson, Chunting Qi, Qiang Yu, Ying Li and Junying Yuan
 
RGMb protects against acute kidney injury by inhibiting tubular cell necroptosis via an MLKL-dependent mechanism
Wenjing Liu, Binbin Chen, Yang Wang, Chenling Meng, Huihui Huang, Xiao-Ru Huang, Jinzhong Qin, Shrikant R. Mulay, Hans-Joachim Anders, Andong Qiu, Baoxue Yang, Gordon J. Freeman, Hua Jenny Lu, Herbert Y. Lin, Zhi-Hua Zheng, Hui-Yao Lan, Yu Huang, and Yin Xia
 
Pharmacological Inhibition of Necroptosis Protects from Dopaminergic Neuronal Cell Death in Parkinson’s Disease Models
Angelo Iannielli, Simone Bido, Lucrezia Folladori, Alice Segnali, Cinzia Cancellieri, Alessandra Maresca, Luca Massimino, Alicia Rubio, Giuseppe Morabito, Leonardo Caporali, Francesca Tagliavini, Olimpia Musumeci, Giuliana Gregato, Erwan Bezard, Valerio Carelli, Valeria Tiranti, Vania Broccoli
 
Epstein-Barr virus encoded latent membrane protein 1 suppresses necroptosis through targeting RIPK1/3 ubiquitination
Xiaolan Liu, Yueshuo Li, Songling Peng, Xinfang Yu, Wei Li, Feng Shi, Xiangjian Luo, Min Tang, Zheqiong Tan, A. M. Bode & Ya Cao
 
 
————————————————-
Other non apoptotic cell death
————————————————-
 
RIPK1-mediated induction of mitophagy compromises the viability of extracellular-matrix-detached cells
Mark A. Hawk, Cassandra L. Gorsuch, Patrick Fagan, Chan Lee, Sung Eun Kim, Jens C. Hamann, Joshua A. Mason, Kelsey J. Weigel, Matyas Abel Tsegaye, Luqun Shen, Sydney Shuff, Junjun Zuo, Stephan Hu, Lei Jiang, Sarah Chapman, W. Matthew Leevy, Ralph J. DeBerardinis, Michael Overholtzer & Zachary T. Schafer
 
The CCR4-NOT deadenylase complex controls Atg7-dependent cell death and heart function
Tomokazu Yamaguchi , Takashi Suzuki, Teruki Sato, Akinori Takahashi, Hiroyuki Watanabe, Ayumi Kadowaki, Miyuki Natsui, Hideaki Inagaki, Satoko Arakawa, Shinji Nakaoka, Yukio Koizumi, Shinsuke Seki, Shungo Adachi, Akira Fukao, Toshinobu Fujiwara, Tohru Natsume, Akinori Kimura, Masaaki Komatsu, Shigeomi Shimizu, Hiroshi Ito, Yutaka Suzuki, Josef M. Penninger, Tadashi Yamamoto, Yumiko Imai, Keiji Kuba
 
 
—————–
Reviews
—————–
 
Bax, Bak and beyond — mitochondrial performance in apoptosis
Aida Peña-Blanco and Ana J. García-Sáez
 
Pyroptosis: an inflammatory link between NAFLD and NASH with potential therapeutic implications
Juliane I. Beier, Jesus M. Banales
 
Apoptosis in megakaryocytes and platelets: the life and death of a lineage
Kate McArthur, Stephane Chappaz and Benjamin T. Kile
 
A matter of life and death: stem cell survival in tissue regeneration and tumour formation
Despina Soteriou & Yaron Fuchs
 
Negative regulators of cell death pathways in cancer: perspective on biomarkers and targeted therapies
Ali Razaghi, Kirsten Heimann, Patrick M. Schaeffer & Spencer B. Gibson
 
Immunological consequences of kidney cell death
Maysa Sarhan, Anne von Mässenhausen, Christian Hugo, Rainer Oberbauer & Andreas Linkermann
 
Cell death-based treatment of glioblastoma
Simone Fulda
 
Necroptosis and neutrophil-associated disorders
Xiaoliang Wang, Shida Yousefi & Hans-Uwe Simon
 
Cell death-based approaches in treatment of the urinary tract-associated diseases: a fight for survival in the killing fields
Diego Martin-Sanchez, Miguel Fontecha-Barriuso, Maria Dolores Sanchez-Niño, Adrian M. Ramos, Ramiro Cabello, Carmen Gonzalez-Enguita, Andreas Linkermann, Ana Belén Sanz & Alberto Ortiz
 
Cell death-based treatment of neuroblastoma
Kadri Valter, Boris Zhivotovsky & Vladimir Gogvadze
 
 
————————
Comments
————————
 
Cell-in-cell phenomena, cannibalism, and autophagy: is there a relationship?
Stefano Fais & Michael Overholtzer
 
LEVERAGING THE IRON-STARVATION RESPONSE TO PROMOTE FERROPTOSIS
Samantha W. Alvarez,  and  Richard Possemato
 
MK2 puts an additional brake on RIPK1 cytotoxic potential
Yves Dondelinger, Tom Delanghe & Mathieu M. J. Bertrand
 
Inflammation NODs to Antagonists of RIP2-XIAP Interaction
Shiyu Xia, Tian-Min Fu, Hao Wu
 
Condemned by metabolism – The kinase RIP3 increases aerobic flux to produce reactive oxygen species
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ApoList – January 2018

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Bcl-2 family proteins
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Measurement of BH3-only protein tolerance
Haiming Dai, Husheng Ding, Kevin L Peterson, X Wei Meng, Paula A Schneider, Katherine L B Knorr & Scott H Kaufmann
http://www.nature.com/articles/cdd2017156

E2F1 interacts with BCL‐xL and regulates its subcellular localization dynamics to trigger cell death
Céline Vuillier, Steven Lohard, Aurélie Fétiveau, Jennifer Allègre, Cémile Kayaci, Louise E King, Frédérique Braun, Sophie Barillé‐Nion, Fabien Gautier, Laurence Dubrez, Andrew P Gilmore, Philippe P Juin and Laurent Maillet
http://EMBOr.embopress.org/content/19/2/234?etoc

Systems modeling accurately predicts responses to genotoxic agents and their synergism with BCL-2 inhibitors in triple negative breast cancer cells.
Lucantoni F, Lindner AU, O’Donovan N, Düssmann H, Prehn JHM.
https://www.nature.com/articles/s41419-017-0039-y

Deubiquitinase USP13 dictates MCL1 stability and sensitivity to BH3 mimetic inhibitors
Shengzhe Zhang, Meiying Zhang, Ying Jing, Xia Yin, Pengfei Ma, Zhenfeng Zhang, Xiaojie Wang, Wen Di & Guanglei Zhuang
https://www.nature.com/articles/s41467-017-02693-9

Crystal Structures of Anti-apoptotic BFL-1 and Its Complex with a Covalent Stapled Peptide Inhibitor
Edward P. Harvey, Hyuk-Soo Seo, Rachel M. Guerra, Gregory H. Bird, Sirano Dhe-Paganon, Loren D. Walensky
https://www.nature.com/articles/nri.2017.9

The BET bromodomain inhibitor CPI203 overcomes resistance to ABT-199 (venetoclax) by downregulation of BFL-1/A1 in in vitro and in vivo models of MYC+/BCL2+ double hit lymphoma
A. Esteve-Arenys, J. G. Valero, A. Chamorro-Jorganes, D. Gonzalez, V. Rodriguez, I. Dlouhy, I. Salaverria, E. Campo, D. Colomer, A. Martinez, G. Rymkiewicz, P. Pérez-Galán, A. Lopez-Guillermo & G. Roué
https://www.nature.com/articles/s41388-017-0111-1

Therapeutic synergy between tigecycline and venetoclax in a preclinical model of MYC/BCL2 double-hit B cell lymphoma
Micol Ravà, Aleco D’Andrea, Paola Nicoli, Ilaria Gritti, Giulio Donati, Mirko Doni, Marco Giorgio, Daniela Olivero and Bruno Amati
http://stm.sciencemag.org/content/10/426/eaan8723?utm_campaign=toc_stm_2018-01-31&et_rid=33946976&et_cid=1822874

A double point mutation at residues Ile14 and Val15 of Bcl-2 uncovers a role for the BH4 domain in both protein stability and function
Giovanni Monaco, Rita La Rovere, Spyridoula Karamanou, Kirsten Welkenhuyzen, Hristina Ivanova, Elien Vandermarliere, Marta Di Martile, Donatella Del Bufalo, Humbert De Smedt, Jan B. Parys, Anastassios Economou and Geert Bultynck
http://onlinelibrary.wiley.com/doi/10.1111/febs.14324/abstract

Iterative optimization yields Mcl-1–targeting stapled peptides with selective cytotoxicity to Mcl-1–dependent cancer cells
Raheleh Rezaei Araghi, Gregory H. Bird, Jeremy A. Ryan, Justin M. Jenson, Marina Godes, Jonathan R. Pritz, Robert A. Grant, Anthony Letai, Loren D. Walensky, and Amy E. Keating
https://www.nature.com/articles/onc2017299

Targeting Mcl-1 enhances DNA replication stress sensitivity to cancer therapy
Guo Chen, Andrew T. Magis, Ke Xu, Dongkyoo Park, David S. Yu, Taofeek K. Owonikoko, Gabriel L. Sica, Sarah W. Satola, Suresh S. Ramalingam, Walter J. Curran, Paul W. Doetsch, and Xingming Deng
https://www.jci.org/articles/view/92742

Caspase cleavage of Mcl-1 impairs its anti-apoptotic activity and proteasomal degradation in non-small lung cancer cells
Ting Wang, Zhiwei Yang, Yimeng Zhang, Xiang Zhang, Lei Wang, Shengli Zhang & Lintao Jia
https://link.springer.com/article/10.1007/s10495-017-1436-5

Proapoptotic PUMA targets stem-like breast cancer cells to suppress metastasis
Qi Sun, Jacqueline Lesperance, Hiromi Wettersten, Elaine Luterstein, Yoko S. DeRose, Alana Welm, David A. Cheresh, and Jay S. Desgrosellier
https://www.jci.org/articles/view/93707

Coordinated repression of BIM and PUMA by Epstein–Barr virus latent genes maintains the survival of Burkitt lymphoma cells
Leah Fitzsimmons, Andrew J Boyce, Wenbin Wei, Catherine Chang, Deborah Croom-Carter et al.
https://www.nature.com/articles/cdd2017150

Predicting effective pro-apoptotic anti-leukaemic drug combinations using co-operative dynamic BH3 profiling
Martin Grundy, Claire Seedhouse, Thomas Jones, Liban Elmi, Michael Hall, Adam Graham, Nigel Russell, Monica Pallis
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0190682

Molecular docking studies of bioactive compounds from Annona muricataLinn as potential inhibitors for Bcl-2, Bcl-w and Mcl-1 antiapoptotic proteins
Mohamad Norisham Mohamad Rosdi, Shahkila Mohd Arif, Mohamad Hafizi Abu Bakar, Siti Aisyah Razali, Razauden Mohamed Zulkifli & Harisun Ya’akob
https://link.springer.com/article/10.1007/s10495-017-1434-7

Sensitisation to mitoxantrone-induced apoptosis by the oncolytic adenovirus Ad∆∆ through Bcl-2-dependent attenuation of autophagy
Carmen Aguirre-Hernández, Héctor Maya-Pineda, Julia San Millán, Y. K. Stella Man, Yong-Jie Lu & Gunnel Halldén
https://www.nature.com/articles/s41389-017-0020-8

Mitochondrial levels determine variability in cell death by modulating apoptotic gene expression
Silvia Márquez-Jurado, Juan Díaz-Colunga, Ricardo Pires das Neves, Antonio Martinez-Lorente, Fernando Almazán, Raúl Guantes & Francisco J. Iborra
https://www.nature.com/articles/s41467-017-02787-4

BAD and KATP channels regulate neuron excitability and epileptiform activity
Juan Ramón Martínez-François, María Carmen Fernández-Agüera, Nidhi Nathwani, Carolina Lahmann, Veronica L Burnham, Nika N Danial, Gary Yellen
https://elifesciences.org/articles/32721

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Caspases, IAPs
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Involvement of both caspase-8 and Noxa-activated pathways in endoplasmic reticulum stress-induced apoptosis in triple-negative breast tumor cells
Ana Cano-González, Marta Mauro-Lizcano, Daniel Iglesias-Serret, Joan Gil & Abelardo López-Rivas
https://www.nature.com/articles/s41419-017-0164-7

Caspase-10: a molecular switch from cell-autonomous apoptosis to communal cell death in response to chemotherapeutic drug treatment
Andrea Mohr, Laura Deedigan, Sylwia Jencz, Yasamin Mehrabadi, Lily Houlden, Stella-Maris Albarenque & Ralf M Zwacka
https://www.nature.com/articles/cdd2017164

Caspase-4 activation by a bacterial surface protein is mediated by cathepsin G in human gingival fibroblasts
Hye-Kyoung Jun, Young-Jung Jung, Suk Ji, Sun-Jin An & Bong-Kyu Choi
https://www.nature.com/articles/cdd2017167

IL-6 receptor blockade corrects defects of XIAP-deficient regulatory T cells
Wan-Chen Hsieh, Tzu-Sheng Hsu, Ya-Jen Chang & Ming-Zong Lai
https://www.nature.com/articles/s41467-018-02862-4

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Death receptors
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Mitochondrial levels determine variability in cell death by modulating apoptotic gene expression
Silvia Márquez-Jurado, Juan Díaz-Colunga, Ricardo Pires das Neves, Antonio Martinez-Lorente, Fernando Almazán, Raúl Guantes & Francisco J. Iborra
https://www.nature.com/articles/s41467-017-02787-4

CANCER PREVENTIVE EFFECT OF RECOMBINANT TRAIL BY ABLATION OF ONCOGENIC INFLAMMATION IN COLITIS-ASSOCIATED CANCER RATHER THAN ANTICANCER EFFECT
Joo-Young Kim, Young-Mi Kim, Jong-Min Park, Young Min Han, Kang Choon Lee, Ki Baik Hahm,  and  Suntaek Hong
http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=view&path%5B%5D=23083&path%5B%5D=72802

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RIPK1, necroptosis
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Ca2+-dependent demethylation of phosphatase PP2Ac promotes glucose deprivation-induced cell death independently of inhibiting glycolysis
Ha Yin Lee , Yoko Itahana, Stefan Schuechner, Masahiro Fukuda, H. Shawn Je, Egon Ogris, David M. Virshup, Koji Itahana
http://stke.sciencemag.org/content/11/512/eaam7893

RIP3 targets pyruvate dehydrogenase complex to increase aerobic respiration in TNF-induced necroptosis
Zhentao Yang , Yan Wang ,Yingying Zhang , Xiadi He, Chuan-Qi Zhong ,Hengxiao Ni , Xin Chen , Yaoji Liang , Jianfeng Wu , Shimin Zhao , Dawang Zhou & Jiahuai Han
http://www.nature.com/articles/s41556-017-0022-y

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Post-death
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Resolvins suppress tumor growth and enhance cancer therapy
Megan L. Sulciner, Charles N. Serhan, Molly M. Gilligan, Dayna K. Mudge, Jaimie Chang, Allison Gartung, Kristen A. Lehner, Diane R. Bielenberg, Birgitta Schmidt, Jesmond Dalli, Emily R. Greene, Yael Gus-Brautbar, Julia Piwowarski, Tadanori Mammoto, David Zurakowski, Mauro Perretti, Vikas P. Sukhatme, Arja Kaipainen, Mark W. Kieran, Sui Huang and Dipak Panigrahy
http://jem.rupress.org/content/215/1/115?etoc

Apoptosis-induced CXCL5 accelerates inflammation and growth of prostate tumor metastases in bone
Hernan Roca, Jacqueline D. Jones, Marta C. Purica, Savannah Weidner, Amy J. Koh, Robert Kuo, John E. Wilkinson, Yugang Wang, Stephanie Daignault-Newton, Kenneth J. Pienta, Todd M. Morgan, Evan T. Keller, Jacques E. Nör, Lonnie D. Shea, and Laurie K. McCauley
https://www.jci.org/articles/view/92466

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Miscellaneous
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Selenium Utilization by GPX4 Is Required to Prevent Hydroperoxide-Induced Ferroptosis
Irina Ingold, Carsten Berndt, Sabine Schmitt, Sebastian Doll, Gereon Poschmann, Katalin Buday, Antonella Roveri, Xiaoxiao Peng, Florencio Porto Freitas, Tobias Seibt, Lisa Mehr, Michaela Aichler, Axel Walch, Daniel Lamp, Martin Jastroch, Sayuri Miyamoto, Wolfgang Wurst, Fulvio Ursini, Elias S.J. Arnér, Noelia Fradejas-Villar, Ulrich Schweizer, Hans Zischka, José Pedro Friedmann Angeli, Marcus Conrad
http://www.cell.com/cell/fulltext/S0092-8674(17)31438-1

The unique histidine in OSCP subunit of F‐ATP synthase mediates inhibition of the permeability transition pore by acidic pH
Manuela Antoniel, Kristen Jones, Salvatore Antonucci, Barbara Spolaore, Federico Fogolari, Valeria Petronilli, Valentina Giorgio, Michela Carraro, Fabio Di Lisa, Michael Forte, Ildikó Szabó, Giovanna Lippe and Paolo Bernardi
http://EMBOr.embopress.org/content/19/2/257?etoc

The Pore-Forming Protein Gasdermin D Regulates Interleukin-1 Secretion from Living Macrophages
Charles L. Evavold, Jianbin Ruan, Yunhao Tan, Shiyu Xia, Hao Wu, Jonathan C. Kagan
http://www.cell.com/immunity/fulltext/S1074-7613(17)30514-9

CDK9‐mediated phosphorylation controls the interaction of TIP60 with the transcriptional machinery
Prisca Brauns‐Schubert, Florian Schubert, Manuela Wissler, Martina Weiss,Lisa Schlicher, Simon Bessler, Mariam Safavi, Cornelius Miething, Christoph Borner, Tilman Brummer and Ulrich Maurer
http://EMBOr.embopress.org/content/19/2/244?etoc

Oxeiptosis, a ROS-induced caspase-independent apoptosis-like cell-death pathway
Cathleen Holze, Chloé Michaudel, Claire Mackowiak, Darya A. Haas, Christian Benda et al.
https://www.nature.com/articles/s41590-017-0013-y

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Reviews
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Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018.
Galluzzi L, et al
https://www.nature.com/articles/s41418-017-0012-4

Structural principles of tumor necrosis factor superfamily signaling
Éva S. Vanamee , Denise L. Faustman
http://stke.sciencemag.org/content/11/511/eaao4910

Evolution of Voltage-Dependent Anion Channel Function: From Molecular Sieve to Governator to Actuator of Ferroptosis
John J. Lemasters
https://www.frontiersin.org/articles/10.3389/fonc.2017.00303/full

Mechanisms of redox metabolism and cancer cell survival during extracellular matrix detachment
Mark A Hawk and Zachary T Schafer
http://www.jbc.org/content/early/2018/01/16/jbc.TM117.000260.abstract

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Comments
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Bcl-2 proteins: Unraveling the details of a complex and dynamic network
Stephanie Bleicken & Ana J. Garcia-Saez
http://www.tandfonline.com/doi/full/10.1080/23723556.2017.1384880

Resolving the dark side of therapy-driven cancer cell death
Eduardo Bonavita, Victoria S. Pelly and Santiago Zelenay
http://jem.rupress.org/content/215/1/9?etoc

An Element of Life
Douglas R. Green
http://www.cell.com/cell/fulltext/S0092-8674(18)30038-2

Apoptotic Regulatory T Cells Retain Suppressive Function through Adenosine
Ulf H. Beier
http://www.cell.com/cell-metabolism/fulltext/S1550-4131(17)30726-X

To die or not to die: Regulatory feedback phosphorylation circuits determine receptor-interacting protein kinase-1 (RIPK1) function
Manoj B. Menon, Julia Gropengießer, Klaus Ruckdeschel & Matthias Gaestel
http://www.tandfonline.com/doi/full/10.1080/23723556.2017.1396389

Switching from TNF-induced inflammation to death signaling
Qing Xu, Swati Choksi & Zhengang Liu
http://www.tandfonline.com/doi/full/10.1080/23723556.2017.1392402

Gasdermin D Flashes an Exit Signal for IL-1
Teneema Kuriakose, Thirumala-Devi Kanneganti
http://www.cell.com/immunity/fulltext/S1074-7613(18)30003-7

Stressed-out ROS take a silent death route
Sannula Kesavardhana & Thirumala-Devi Kanneganti
https://www.nature.com/articles/s41590-017-0034-6

Pulling the BAX trigger for tumor cell death
Denis E. Reyna and Evripidis Gavathiotis
https://doi.org/10.18632/oncotarget.24201

Novel drug combination unleashes apoptosis in AML
http://stm.sciencemag.org/content/10/422/eaar7509


Journal Club: Mitochondria: back to the future
Navdeep S. Chandel
https://www.nature.com/articles/nrm.2017.133

Obituary
Janet A. Houghton, PhD: In Memoriam (1952–2017)
Mark J. Suto
http://cancerres.aacrjournals.org/content/78/1/5

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