ApoList – June 2022


Caspases


Caspase-7 activates ASM to repair gasdermin and perforin pores – Kengo Nozaki, Vivien I. Maltez, Manira Rayamajhi, Alan L. Tubbs, Joseph E. Mitchell, Carolyn A. Lacey, Carissa K. Harvest, Lupeng Li, William T. Nash, Heather N. Larson, Benjamin D. McGlaughon, Nathaniel J. Moorman, Michael G. Brown, Jason K. Whitmire and Edward A. Miao. https://www.nature.com/articles/s41586-022-04825-8

Caspase‐8 in endothelial cells maintains gut homeostasis and prevents small bowel inflammation in mice – Nathalie Tisch, Carolin Mogler, Ana Stojanovic, Robert Luck, Emilia A Korhonen, Alexander Ellerkmann, Heike Adler, Mahak Singhal, Géza Schermann, Lena Erkert, Jay V Patankar, Andromachi Karakatsani, Anna-Lena Scherr, Yaron Fuchs, Adelheid Cerwenka, Stefan Wirtz, Bruno Christian Köhler, Hellmut G Augustin, Christoph Becker, Thomas Schmidt, Carmen Ruiz de Almodóvar. https://www.embopress.org/doi/full/10.15252/emmm.202114121

Myeloid caspase-8 restricts RIPK3-dependent proinflammatory IL-1β production and CD4 T cell activation in autoimmune demyelination – Sunja Kim, Hsueh Chung Lu, Andrew J. Steelman and Jianrong Li. https://www.pnas.org/doi/10.1073/pnas.2117636119

Cytoplasmic innate immune sensing by the caspase-4 non-canonical inflammasome promotes cellular senescence – Irene Fernández-Duran, Andrea Quintanilla, Núria Tarrats, Jodie Birch, Priya Hari, Fraser R. Millar, Anthony B. Lagnado, Vanessa Smer-Barreto, Morwenna Muir, Valerie G. Brunton, João F. Passos and Juan Carlos Acosta. https://www.nature.com/articles/s41418-021-00917-6

Mechanistic insights into the activation of the IKK kinase complex by the Kaposi’s sarcoma herpes virus oncoprotein vFLIP – Claire Bagnéris, Swathi L. Senthil Kumar, Mehdi Baratchian, Hannah M. Britt, Tufa E. Assafa, Konstantinos Thalassinos, Mary K. Collins, Tracey E. Barrett. https://www.jbc.org/article/S0021-9258(22)00452-5/fulltext


Necroptosis


Human RIPK3 C-lobe phosphorylation is essential for necroptotic signaling – Yanxiang Meng, Christopher R. Horne, Andre L. Samson, Laura F. Dagley, Samuel N. Young, Jarrod J. Sandow, Peter E. Czabotar and James M. Murphy. https://www.nature.com/articles/s41419-022-05009-y


Pyroptosis


Nanobodies dismantle post‐pyroptotic ASC specks and counteract inflammation in vivo – Damien Bertheloot, Carlos WS Wanderley, Ayda H Schneider, Lisa DJ Schiffelers, Jennifer D Wuerth, Jan MP Tödtmann, Salie Maasewerd, Ibrahim Hawwari, Fraser Duthie, Cornelia Rohland, Lucas S Ribeiro, Lea-Marie Jenster, Nathalia Rosero, Yonas M Tesfamariam, Fernando Q Cunha, Florian I Schmidt, Bernardo S Franklin. https://www.embopress.org/doi/full/10.15252/emmm.202115415

Targeting of GSDMD sensitizes HCC to anti-PD-1 by activating cGAS pathway and downregulating PD-L1 expression – Tingting Lv, Xiaofeng Xiong, Wei Yan, Mei Liu, Hongwei Xu and Qin He. https://jitc.bmj.com/content/10/6/e004763


Ferroptosis


Cancer cells dying from ferroptosis impede dendritic cell-mediated anti-tumor immunity – Bartosz Wiernicki, Sophia Maschalidi, Jonathan Pinney, Sandy Adjemian, Tom Vanden Berghe, Kodi S. Ravichandran and Peter Vandenabeele. https://www.nature.com/articles/s41467-022-31218-2

Ferroptosis mediates selective motor neuron death in amyotrophic lateral sclerosis – Taide Wang, Doris Tomas, Nirma D. Perera, Brittany Cuic, Sophia Luikinga, Aida Viden, Samantha K. Barton, Catriona A. McLean, André L. Samson, Adam Southon, Ashley I. Bush, James M. Murphy and Bradley J. Turner. https://www.nature.com/articles/s41418-021-00910-z

A ferroptosis defense mechanism mediated by glycerol-3-phosphate dehydrogenase 2 in mitochondria – Shiqi Wu, Chao Mao, Lavanya Kondiparthi, Masha V. Poyurovsky, Kellen Olszewski and Boyi Gan. https://www.pnas.org/doi/10.1073/pnas.2121987119


Miscellanous


Optogenetic activators of apoptosis, necroptosis, and pyroptosis – Kateryna Shkarina, Eva Hasel de Carvalho, José Carlos Santos, Saray Ramos, Maria Leptin, Petr Broz. https://rupress.org/jcb/article/221/6/e202109038/213145

DRP1 levels determine the apoptotic threshold during embryonic differentiation through a mitophagy-dependent mechanism – Barbara Pernaute, Salvador Pérez-Montero, Juan Miguel Sánchez Nieto, Aida Di Gregorio, Ana Lima, Katerina Lawlor, Sarah Bowling, Gianmaria Liccardi, Alejandra Tomás, Pascal Meier, Hiromi Sesaki, Guy A. Rutter, Ivana Barbaric, Tristan A. Rodríguez. https://www.cell.com/developmental-cell/fulltext/S1534-5807(22)00306-9

A signature for pan-cancer prognosis based on neutrophil extracellular traps – Yi Zhang, Liping Guo, Qichen Dai, Bingqing Shang, Ting Xiao, Xuebing Di, Kaitai Zhang, Lin Feng, Jianzhong Shou and Yipeng Wang. https://jitc.bmj.com/content/10/6/e004210

TIR domains of plant immune receptors are 2′,3′-cAMP/cGMP synthetases mediating cell death – Dongli Yu, Wen Song, Eddie Yong Jun Tan, Li Liu, Yu Cao, Jan Jirschitzka, Ertong Li, Elke Logemann, Chenrui Xu, Shijia Huang, Aolin Jia, Xiaoyu Chang, Zhifu Han, Bin Wu, Paul Schulze-Lefert, Jijie Chai. https://www.cell.com/cell/fulltext/S0092-8674(22)00530-X


Reviews


What can we learn from mice lacking pro-survival BCL-2 proteins to advance BH3 mimetic drugs for cancer therapy? – Kerstin Brinkmann, Ashley P. Ng, Carolyn A. de Graaf and Andreas Strasser. https://www.nature.com/articles/s41418-022-00987-0

Paradoxical roles of caspase-3 in regulating cell survival, proliferation, and tumorigenesis – Ebrahim Eskandari, Connie J. Eaves. https://rupress.org/jcb/article/221/6/e202201159/213213

Structural Details of BH3 Motifs and BH3-Mediated Interactions: an Updated Perspective – Valentina Sora and Elena Papaleo. https://www.frontiersin.org/articles/10.3389/fmolb.2022.864874/full

Ferroptosis at the intersection of lipid metabolism and cellular signaling – Deguang Liang, Alexander M. Minikes, Xuejun Jiang. https://www.cell.com/molecular-cell/fulltext/S1097-2765(22)00260-X

Cell Death-Related Ubiquitin Modifications in Inflammatory Syndromes: From Mice to Men – Nieves Peltzer and Alessandro Annibaldi. https://www.mdpi.com/2227-9059/10/6/1436


Comments


Killing cells using light (activated) sabers – Stephen W.G. Tait. https://rupress.org/jcb/article/221/6/e202205018/213218

BAX and BAK dynamics control mitochondrial DNA release during apoptosis – Takahiro Yamazaki and Lorenzo Galluzzi. https://www.nature.com/articles/s41418-022-00985-2

ApoList – May 2022


Bcl-2 family proteins


Mitochondrial dynamics regulate genome stability via control of caspase-dependent DNA damage – Kai Cao, Joel S. Riley, Rosalie Heilig, Alfredo E. Montes-Gómez, Esmee Vringer, Kevin Berthenet, Catherine Cloix, Yassmin Elmasry, David G. Spiller, Gabriel Ichim, Kirsteen J. Campbell, Andrew P. Gilmore, Stephen W.G. Tait. https://www.cell.com/developmental-cell/fulltext/S1534-5807(22)00229-5

Disruption of mitochondrial quality control genes promotes caspase-resistant cell survival following apoptotic stimuli – Yulia Kushnareva, Vivian Moraes, Julian Suess, Bjoern Peters, Donald D. Newmeyer, Tomomi Kuwana. https://www.jbc.org/article/S0021-9258(22)00275-7/fulltext

Bcl-xL enforces a slow-cycling state necessary for survival in the nutrient-deprived microenvironment of pancreatic cancer – Yogev Sela, Jinyang Li, Shivahamy Maheswaran, Robert J Norgard, Salina Yuan, Maimon E Hubbi, Miriam Doepner, Jimmy P Xu, Elaine S Ho, Clementina Mesaros, Colin Sheehan, Grace Croley, Alexander Muir, Ian A Blair, Ophir Shalem, Chi V Dang, Ben Z Stanger. https://aacrjournals.org/cancerres/article-abstract/doi/10.1158/0008-5472.CAN-22-0431/682341

Acetic acid triggers cytochrome c release in yeast heterologously expressing human Bax – Joana P. Guedes, Vitória Baptista, Cátia Santos-Pereira, Maria João Sousa, Stéphen Manon, Susana R. Chaves, Manuela Côrte-Real. https://link.springer.com/article/10.1007/s10495-022-01717-0

Increased apoptotic sensitivity of glioblastoma enables therapeutic targeting by BH3-mimetics – Anna L. Koessinger, Catherine Cloix, Dominik Koessinger, Dieter Henrik Heiland, Florian J. Bock, Karen Strathdee, Kevin Kinch, Laura Martínez-Escardó, Nikki R. Paul, Colin Nixon, Gaurav Malviya, Mark R. Jackson, Kirsteen J. Campbell, Katrina Stevenson, Sandeep Davis, Yassmin Elmasry, Asma Ahmed, Jim O’Prey, Gabriel Ichim, Oliver Schnell, William Stewart, Karen Blyth, Kevin M. Ryan, Anthony J. Chalmers, Jim C. Norman and Stephen W. G. Tait. https://www.nature.com/articles/s41418-022-01001-3


Death receptors


Tankyrase-mediated ADP-ribosylation is a regulator of TNF-induced death – Lin Liu, Jarrod J. Sandow, Deena M. Leslie Pedrioli, Andre L. Samson, Natasha Silke, Tobias Kratina, Rebecca L. Ambrose, Marcel Doerflinger, Zhaoqing Hu, Emma Morrish, Diep Chau, Andrew J. Kueh, Cheree Fitzibbon, Marc Pellegrini, Jaclyn S. Pearson, Michael O. Hottiger, Andrew I. Webb, Najoua Lalaoui, John Silke. https://www.science.org/doi/full/10.1126/sciadv.abh2332

Human B Cells Mediate Innate Anti-Cancer Cytotoxicity Through Concurrent Engagement of Multiple TNF Superfamily Ligands – Bratislav M Janjic, Aditi Kulkarni, Robert L Ferris, Lazar Vujanovic, Nikola L Vujanovic. https://www.frontiersin.org/articles/10.3389/fimmu.2022.837842/full

FasL microgels induce immune acceptance of islet allografts in nonhuman primates – Ji Lei, María M. Coronel, Esma S. Yolcu, Hongping Deng, Orlando Grimany-Nuno, Michael D. Hunckler, Vahap Ulker, Zhihong Yang, Kang M. Lee, Alexander Zhang, Hao Luo, Cole W. Peters, Zhongliang Zou, Tao Chen, Zhenjuan Wang, Colleen S. McCoy, Ivy A. Rosales, James F. Markmann, Haval Shirwan, Andrés J. García. https://www.science.org/doi/full/10.1126/sciadv.abm9881


Caspases and IAPs


Pathogen hijacks programmed cell death signaling by arginine ADPR-deacylization of caspases – Ting Peng, Xinyuan Tao, Zhujun Xia, Shufan Hu, Juan Xue, Qiuyu Zhu, Xing Pan, Qiang Zhang, Shan Li. https://www.cell.com/molecular-cell/fulltext/S1097-2765(22)00219-2

Caspase cleavage and nuclear retention of the energy sensor AMPK-α1 during apoptosis – Anees Rahman Cheratta, Faisal Thayyullathil, Simon A. Hawley, Fiona A. Ross, Abdelmajdid Atrih, Douglas J. Lamont, Siraj Pallichankandy, Karthikeyan Subburayan, Ameer Alakkal, Rachid Rezgui, Alex Gray, D. Grahame Hardie, Sehamuddin Galadari. https://www.cell.com/cell-reports/fulltext/S2211-1247(22)00525-3

Caspase-9b drives cellular transformation, lung inflammation, and lung tumorigenesis – Minjung Kim, Ngoc T Vu, Xue Wang, Gamze B Bulut, Min-Hsuan Wang, Cora Uram-Tuculescu, Raghavendra Pillappa, Sungjune Kim, Charles E Chalfant.. https://aacrjournals.org/mcr/article/doi/10.1158/1541-7786.MCR-21-0905/696288/

XIAP promotes melanoma growth by inducing tumour neutrophil infiltration – Mila Daoud, Pia Nora Broxtermann, Fabian Schorn, J Paul Werthenbach, Jens Michael Seeger, Lars M Schiffmann, Kerstin Brinkmann, Domagoj Vucic, Thomas Tüting, Cornelia Mauch, Dagmar Kulms, Paola Zigrino, Hamid Kashkar. https://www.embopress.org/doi/full/10.15252/embr.202153608


Necroptosis


Osmotic stress activates RIPK3/MLKL-mediated necroptosis by increasing cytosolic pH through a plasma membrane Na+/H+ exchanger – Wenbin Zhang, Weiliang Fan, Jia Guo, Xiaodong Wang. https://www.science.org/doi/abs/10.1126/scisignal.abn5881

Z-DNA binding protein 1 promotes heatstroke-induced cell death – Fangfang Yuan, Jizhen Cai, Jianfeng Wu, Yiting Tang, Kai Zhao, Fang Liang, Fanglin Li, Xinyu Yang, Zhihui He, Timothy R. Billiar, Haichao Wang, Lei Su, Ben Lu. https://www.science.org/doi/abs/10.1126/science.abg5251

ADAR1 masks the cancer immunotherapeutic promise of ZBP1-driven necroptosis – Ting Zhang, Chaoran Yin, Aleksandr Fedorov, Liangjun Qiao, Hongliang Bao, Nazar Beknazarov, Shiyu Wang, Avishekh Gautam, Riley M. Williams, Jeremy Chase Crawford, Suraj Peri, Vasily Studitsky, Amer A. Beg, Paul G. Thomas, Carl Walkley, Yan Xu, Maria Poptsova, Alan Herbert and Siddharth Balachandran. https://www.nature.com/articles/s41586-022-04753-7


Pyroptosis


GSDMEa-mediated pyroptosis is bi-directionally regulated by caspase and required for effective bacterial clearance in teleost – Hang Xu, Shuai Jiang, Chao Yu, Zihao Yuan and Li Sun. https://www.nature.com/articles/s41419-022-04896-5


Efferocytosis, entosis etc


Targeting SLC7A11 improves efferocytosis by dendritic cells and wound healing in diabetes – Sophia Maschalidi, Parul Mehrotra, Burcu N. Keçeli, Hannah K. L. De Cleene, Kim Lecomte, Renée Van der Cruyssen, Pauline Janssen, Jonathan Pinney, Geert van Loo, Dirk Elewaut, Ann Massie, Esther Hoste and Kodi S. Ravichandran. https://www.nature.com/articles/s41586-022-04754-6

Cooperative epithelial phagocytosis enables error correction in the early embryo – Esteban Hoijman, Hanna-Maria Häkkinen, Queralt Tolosa-Ramon, Senda Jiménez-Delgado, Chris Wyatt, Marta Miret-Cuesta, Manuel Irimia, Andrew Callan-Jones, Stefan Wieser and Verena Ruprecht. https://www.nature.com/articles/s41586-021-03200-3

Neuronal apoptosis drives remodeling states of microglia and shifts in survival pathway dependence -Sarah Rose Anderson, Jacqueline M Roberts, Nathaniel Ghena, Emmalyn A Irvin, Joon Schwakopf, Isabelle B Cooperstein, Alejandra Bosco, Monica L Vetter. https://elifesciences.org/articles/76564

Toll-9 interacts with Toll-1 to mediate a feedback loop during apoptosis-induced proliferation in Drosophila – Alicia Shields, Alla Amcheslavsky, Elizabeth Brown, Tom V. Lee, Yingchao Nie, Takahiro Tanji, Y. Tony Ip, Andreas Bergmann. https://www.cell.com/cell-reports/fulltext/S2211-1247(22)00588-5

Extracellular ATP facilitates cell extrusion from epithelial layers mediated by cell competition or apoptosis – Yusuke Mori, Naoka Shiratsuchi, Nanami Sato, Azusa Chaya, Nobuyuki Tanimura, Susumu Ishikawa, Mugihiko Kato, Ikumi Kameda, Shunsuke Kon, Yukinari Haraoka, Tohru Ishitani, Yasuyuki Fujita. https://www.cell.com/current-biology/fulltext/S0960-9822(22)00491-2


Miscellanous


Erebosis, a new cell death mechanism during homeostatic turnover of gut enterocytes – Hanna M. Ciesielski, Hiroshi Nishida, Tomomi Takano, Aya Fukuhara, Tetsuhisa Otani, Yuko Ikegawa, Morihiro Okada, Takashi Nishimura, Mikio Furuse, Sa Kan Yoo. https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3001586

Robust transcriptional indicators of immune cell death revealed by spatio-temporal transcriptome analyses – Jose Salguero-Linares, Irene Serrano, Nerea Ruiz-Solani, Marta Salas-Gómez, Ujjal Jyoti Phukan, Victor Manuel González, Martí Bernardo-Faura, Marc Valls, David Rengel, Nuria S. Coll. https://www.cell.com/molecular-plant/fulltext/S1674-2052(22)00147-2

Fatty acid oxidation protects cancer cells from apoptosis by increasing mitochondrial membrane lipids – Yi-Jia Li, Johannes Francois Fahrmann, Maryam Aftabizadeh, Qianqian Zhao, Satyendra C. Tripathi, Chunyan Zhang, Yuan Yuan, David Ann, Samir Hanash, Hua Yu. https://www.cell.com/cell-reports/fulltext/S2211-1247(22)00645-3

PI(18:1/18:1) is a SCD1-derived lipokine that limits stress signaling – Maria Thürmer, André Gollowitzer, Helmut Pein, Konstantin Neukirch, Elif Gelmez, Lorenz Waltl, Natalie Wielsch, René Winkler, Konstantin Löser, Julia Grander, Madlen Hotze, Sönke Harder, Annika Döding, Martina Meßner, Fabiana Troisi, Maximilian Ardelt, Hartmut Schlüter, Johanna Pachmayr, Óscar Gutiérrez-Gutiérrez, Karl Lenhard Rudolph, Kathrin Thedieck, Ulrike Schulze-Späte, Cristina González-Estévez, Christian Kosan, Aleš Svatoš, Marcel Kwiatkowski and Andreas Koeberle. https://www.nature.com/articles/s41467-022-30374-9

Flow cytometric single cell-based assay to simultaneously detect cell death, cell cycling, DNA content and cell senescence – Elizabeth Lieschke, Zilu Wang, Catherine Chang, Clare E. Weeden, Gemma L. Kelly and Andreas Strasser. https://www.nature.com/articles/s41418-022-00964-7


Reviews


Adapted to Survive: Targeting Cancer Cells with BH3 Mimetics – Joan Montero and Rizwan Haq. https://aacrjournals.org/cancerdiscovery/article/12/5/1217/694529

Protein–protein and protein–lipid interactions of pore-forming BCL-2 family proteins in apoptosis initiation – Giridhar Sekar, Adedolapo Ojoawo, Tudor Moldoveanu. https://portlandpress.com/biochemsoctrans/article-abstract/doi/10.1042/BST20220323/231272

Immunogenic cell stress and injury versus immunogenic cell death: implications for improving cancer treatment with immune checkpoint blockade – Ganapathy Sriram, Tiffany R Emmons, Lauren E Milling, Darrell J Irvine, Michael B Yaffe. https://www.tandfonline.com/doi/full/10.1080/23723556.2022.2039038

Targeting the apoptosis pathway to treat tumours of the paediatric nervous system – Marie-Claire Fitzgerald, Philip J. O’Halloran, Niamh M. C. Connolly and Brona M. Murphy. https://www.nature.com/articles/s41419-022-04900-y

Of the many cellular responses activated by TP53, which ones are critical for tumour suppression? – Annabella F. Thomas, Gemma L. Kelly and Andreas Strasser. https://www.nature.com/articles/s41418-022-00996-z

No longer married to inflammasome signaling: the diverse interacting pathways leading to pyroptotic cell death – Ashley Weir, James E. Vince. https://portlandpress.com/biochemj/article/479/10/1083/231341

Deubiquitinases in cell death and inflammation – Kim Newton, Alexander D. Gitlin. https://portlandpress.com/biochemj/article/479/10/1103/231340

RIP1 post-translational modifications – Eugene Varfolomeev, Domagoj Vucic. https://portlandpress.com/biochemj/article-abstract/479/9/929/231273


Comments


[AMPK] Cleaved to keep dying cells alive – Leslie K. Ferrarelli. https://www.science.org/doi/full/10.1126/scisignal.abq8516

A novel crosstalk between autophagosomes and phagosomes that facilitates the clearance of apoptotic cells – Zheng Zhou and Omar Peña-Ramos. https://www.tandfonline.com/doi/abs/10.1080/15548627.2022.2080384

Cuproptosis: Cellular and molecular mechanisms underlying copper-induced cell death – Paul A. Cobine, Donita C. Brady. https://www.cell.com/molecular-cell/fulltext/S1097-2765(22)00435-X

IFNγ regulates ferroptosis with fatty acids – Zhe Wang. https://www.nature.com/articles/s41556-022-00921-z

ATP and ROS signal cell extrusion – Paulina Strzyz. https://www.nature.com/articles/s41580-022-00487-6


European Workshop on Cell Death in Fiuggi (near Roma) June 22: registration and poster submission still open if you can pay registration before June 10th. See you there!

https://www.ewcd.eu/

ECDO 2022 in Bonn, september. https://www.ecdo.eu/

ApoList – April 2022


Bcl-2 family proteins


Some mice lacking intrinsic, as well as death  receptor induced apoptosis and necroptosis, can survive to adulthood – Francine F. S. Ke,  Kerstin Brinkmann, Anne K. Voss and Andreas Strasser. https://www.nature.com/articles/s41419-022-04731-x

Augmenting NK cell-based immunotherapy by targeting mitochondrial apoptosis – Rongqing Pan, Jeremy Ryan, Deng Pan, Kai W. Wucherpfennig, Anthony Letai. https://www.cell.com/cell/fulltext/S0092-8674(22)00340-3

Single-cell transcriptomics identifies Mcl-1 as a target for senolytic therapy in cancer – Martina Troiani, Manuel Colucci, Mariantonietta D’Ambrosio, Ilaria Guccini, Emiliano Pasquini, Angelica Varesi, Aurora Valdata, Simone Mosole, Ajinkya Revandkar, Giuseppe Attanasio, Andrea Rinaldi, Anna Rinaldi, Marco Bolis, Pietro Cippà and Andrea Alimonti. https://www.nature.com/articles/s41467-022-29824-1

Efficacy and specificity of inhibitors of BCL-2 family protein interactions assessed by affinity measurements in live cells – Elizabeth J. Osterlund, Nehad Hirmiz, James M. Pemberton, Adrien Nougarède, Qian Liu, Brian Leber, Qiyin Fang, David W. Andrews. https://www.science.org/doi/full/10.1126/sciadv.abm7375

MEK and MCL-1 sequential inhibition synergize to enhance rhabdomyosarcoma treatment – Clara Alcon, Fernando Martín, Estela Prada, Jaume Mora, Aroa Soriano, Gabriela Guillén, Soledad Gallego, Josep Roma, Josep Samitier, Alberto Villanueva and Joan Montero. https://www.nature.com/articles/s41420-022-00959-w

DRP1 interacts directly with BAX to induce its activation and apoptosis – Andreas Jenner, Aida Peña-Blanco, Raquel Salvador-Gallego, Begoña Ugarte-Uribe, Cristiana Zollo, Tariq Ganief, Jan Bierlmeier, Markus Mund, Jason E Lee, Jonas Ries, Dirk Schwarzer, Boris Macek, Ana J Garcia-Saez. https://www.embopress.org/doi/full/10.15252/embj.2021108587


Death receptors


TNF-α sculpts a maturation process in vivo by pruning tolerogenic dendritic cells – Courtney A. Iberg, Jessica Bourque, Ian Fallahee, Sungho Son, Daniel Hawiger. https://www.cell.com/cell-reports/fulltext/S2211-1247(22)00409-0

CDK4/6 Inhibition Suppresses p73 Phosphorylation and Activates DR5 to Potentiate Chemotherapy and Immune Checkpoint Blockade – Jingshan Tong, Xiao Tan, Xiangping Song, Man Gao, Denise Risnik, Suisui Hao, Kaylee Ermine, Peng Wang, Hua Li, Yi Huang, Jian Yu, Lin Zhang. https://aacrjournals.org/cancerres/article-abstract/82/7/1340/694058

Inflammation induces pro-NETotic neutrophils via TNFR2 signaling – Friederike Neuenfeldt, Jan Christoph Schumacher, Ricardo Grieshaber-Bouyer, Jüri Habicht, Jutta Schröder-Braunstein, Annika Gauss, Uta Merle, Beate Niesler, Niko Heineken, Alexander Dalpke, Matthias M. Gaida, Thomas Giese, Stefan Meuer, Yvonne Samstag, Guido Wabnitz. https://www.cell.com/cell-reports/fulltext/S2211-1247(22)00471-5?dgcid=raven_jbs_etoc_email


Caspases


Non-apoptotic activation of Drosophila caspase-2/9 modulates JNK signaling, the tumor microenvironment, and growth of wound-like tumors – Derek Cui Xu, Li Wang, Kenneth M. Yamada, Luis Alberto Baena-Lopez. https://www.cell.com/cell-reports/fulltext/S2211-1247(22)00479-X

The caspase-2 substrate p54nrb exhibits a multifaceted role in tumor cell death susceptibility via gene regulatory functions – Madeleine Eichler, Ute Distler, Usman Nasrullah, Aswini Krishnan, Manuel Kaulich, Koraljka Husnjak, Wolfgang Eberhardt, Krishnaraj Rajalingam, Stefan Tenzer, Josef Pfeilschifter and Gergely Imre. https://www.nature.com/articles/s41419-022-04829-2


Necroptosis


Mosaic composition of RIP1–RIP3 signalling hub and its role in regulating cell death – Xin Chen, Rongfeng Zhu, Jinjin Zhong, Yongfa Ying, Wenxin Wang, Yating Cao, Hanyi Cai, Xiang Li, Jianwei Shuai and Jiahuai Han. https://www.nature.com/articles/s41556-022-00854-7

The interferon-stimulated gene RIPK1 regulates cancer cell intrinsic and extrinsic resistance to immune checkpoint blockade – Lisa Cucolo, Qingzhou Chen, Jingya Qiu, Yongjun Yu, Max Klapholz, Krista A. Budinich, Zhaojun Zhang, Yue Shao, Igor E. Brodsky, Martha S. Jordan, D. Gary Gilliland, Nancy R. Zhang, Junwei Shi, Andy J. Minn. https://www.cell.com/immunity/fulltext/S1074-7613(22)00130-3

CAMK2/CaMKII activates MLKL in short-term starvation to facilitate autophagic flux – Qionghui Zhan, Jaepyo Jeon, Ying Li, Yu Huang, Jian Xiong, Qiaochu Wang, Tian-Le Xu, Yong Li, Fu-Hai Ji, Guangwei Du and Michael X Zhu. https://www.tandfonline.com/doi/full/10.1080/15548627.2021.1954348

MLKL deficiency in BrafV600EPten−/− melanoma model results in a modest delay of nevi development and reduced lymph node dissemination in male mice – Sofie Martens, Nozomi Takahashi, Gillian Blancke, Niels Vandamme, Hanne Verschuere, Tatyana Divert, Marnik Vuylsteke, Geert Berx and Peter Vandenabeele. https://www.nature.com/articles/s41419-022-04819-4


Pyroptosis


Activation and manipulation of inflammasomes and pyroptosis during bacterial infections – Elliott M. Bernard, Petr Broz. https://portlandpress.com/biochemj/article-abstract/479/7/867/231175


Ferroptosis


CD8+ T cells and fatty acids orchestrate tumor ferroptosis and immunity via ACSL4 – Peng Liao, Weimin Wang, Weichao Wang, Ilona Kryczek, Xiong Li, Yingjie Bian, Amanda Sell, Shuang Wei, Sara Grove, Jeffrey K. Johnson, Paul D. Kennedy, Miguel Gijón, Yatrik M. Shah, Weiping Zou. https://www.cell.com/cancer-cell/fulltext/S1535-6108(22)00036-8

Ferroptosis in plants: regulation of lipid peroxidation and redox status – Ayelén Mariana Distéfano, Gabriel Alejandro López, Victoria Bauer, Eduardo Zabaleta, Gabriela Carolina Pagnussat. https://portlandpress.com/biochemj/article-abstract/479/7/857/231174


Efferocytosis, entosis etc


Stem cell conversion to the cardiac lineage requires nucleotide signalling from apoptosing cells – Loic Fort, Vivian Gama and Ian G. Macara. https://www.nature.com/articles/s41556-022-00888-x

Macrophages use apoptotic cell-derived methionine and DNMT3A during efferocytosis to promote tissue resolution – Patrick B. Ampomah, Bishuang Cai, Santosh R. Sukka, Brennan D. Gerlach, Arif Yurdagul Jr, Xiaobo Wang, George Kuriakose, Lancia N. F. Darville, Yan Sun, Simone Sidoli, John M. Koomen, Alan R. Tall and Ira Tabas. https://www.nature.com/articles/s42255-022-00551-7


Miscellanous


Early SRC activation skews cell fate from apoptosis to senescence – Carlos Anerillas, Allison B. Herman, Martina Rossi, Rachel Munk, Elin Lehrmann, Jennifer L. Martindale, Chang-Yi Cui, Kotb Abdelmohsen, Supriyo De, Myriam Gorospe. https://www.science.org/doi/full/10.1126/sciadv.abm0756

NAMPT-dependent NAD+ salvage is crucial for the decision between apoptotic and necrotic cell death under oxidative stress – Takuto Nishida, Isao Naguro and Hidenori Ichijo. https://www.nature.com/articles/s41420-022-01007-3

Yeast cell death pathway requiring AP-3 vesicle trafficking leads to vacuole/lysosome membrane permeabilization -Zachary D. Stolp, Madhura Kulkarni, Yining Liu, Chengzhang Zhu, Alizay Jalisi, Si Lin, Arturo Casadevall, Kyle W. Cunningham, Fernando J. Pineda, Xinchen Teng, J. Marie Hardwick. https://www.cell.com/cell-reports/fulltext/S2211-1247(22)00399-0


Reviews / comments


Immunogenic cell stress and death – Guido Kroemer, Claudia Galassi, Laurence Zitvogel and Lorenzo Galluzzi. https://www.nature.com/articles/s41590-022-01132-2

RIPK1 and RIPK3 form mosaic necrosomes – Weiwei Qi and Junying Yuan. https://www.nature.com/articles/s41556-022-00879-y

RIP(K)ing away immunotherapy resistance – Mira A. Patel, Sohail F. Tavazoie. https://www.cell.com/immunity/fulltext/S1074-7613(22)00133-9

Dying cell-derived SAM switches off inflammation – Roel P. H. De Maeyer and Derek W. Gilroy. https://www.nature.com/articles/s42255-022-00556-2


EMBO Journal cover – Jenner et al

https://www.embopress.org/cms/asset/9ba6ed7a-df0b-4d7c-9afb-268eb7547e11/embj.v41.8.cover.jpg

ApoList – March 2022


Bcl-2 family proteins


The interplay between BAX and BAK tunes apoptotic pore growth to control mitochondrial-DNA-mediated inflammation – Katia Cosentino, Vanessa Hertlein, Andreas Jenner, Timo Dellmann, Milos Gojkovic, Aida Peña-Blanco, Shashank Dadsena, Noel Wajngarten, John S.H. Danial, Jervis Vermal Thevathasan, Markus Mund, Jonas Ries, Ana J. Garcia-Saez. https://www.cell.com/molecular-cell/fulltext/S1097-2765(22)00008-9

Co-targeting of BAX and BCL-XL proteins broadly overcomes resistance to apoptosis in cancer – Andrea Lopez, Denis E. Reyna, Nadege Gitego, Felix Kopp, Hua Zhou, Miguel A. Miranda-Roman, Lars Ulrik Nordstrøm, Swathi-Rao Narayanagari, Ping Chi, Eduardo Vilar, Aristotelis Tsirigos and Evripidis Gavathiotis. https://www.nature.com/articles/s41467-022-28741-7

Pharmacologic Reduction of Mitochondrial Iron Triggers a Noncanonical BAX/BAK-Dependent Cell Death – Sylvain Garciaz, Andrew A. Guirguis, Sebastian Müller, Fiona C. Brown, Yih-Chih Chan, Ali Motazedian, Caitlin L. Rowe, James A. Kuzich, Kah Lok Chan, Kevin Tran, Lorey Smith, Laura MacPherson, Brian Liddicoat, Enid Y.N. Lam, Tatiana Cañeque, Marian L. Burr, Véronique Litalien, Giovanna Pomilio, Mathilde Poplineau, Estelle Duprez, Sarah-Jane Dawson, Georg Ramm, Andrew G. Cox, Kristin K. Brown, David C.S. Huang, Andrew H. Wei, Kate McArthur, Raphaël Rodriguez, Mark A. Dawson. https://aacrjournals.org/cancerdiscovery/article/12/3/774/681925

Potent, p53-independent induction of NOXA sensitizes MLL-rearranged B-cell acute lymphoblastic leukemia cells to venetoclax – Klaudyna Fidyt, Agata Pastorczak, Julia Cyran, Nicholas T. Crump, Agnieszka Goral, Joanna Madzio, Angelika Muchowicz, Martyna Poprzeczko, Krzysztof Domka, Lukasz Komorowski, Magdalena Winiarska, Joe R. Harman, Karolina Siudakowska, Agnieszka Graczyk-Jarzynka, Elzbieta Patkowska, Ewa Lech-Maranda, Wojciech Mlynarski, Jakub Golab, Thomas A. Milne and Malgorzata Firczuk. https://www.nature.com/articles/s41388-022-02196-y

Overcoming acquired resistance to third-generation EGFR inhibitors by targeting activation of intrinsic apoptotic pathway through Mcl-1 inhibition, Bax activation, or both – Guangzhi Ma, Yunfu Deng, Luxi Qian, Karin A. Vallega, Guojing Zhang, Xingming Deng, Taofeek K. Owonikoko, Suresh S. Ramalingam, Douglas D. Fang, Yifan Zhai and Shi-Yong Sun. https://www.nature.com/articles/s41388-022-02200-5

Targeting mitochondrial respiration and the BCL2 family in high‐grade MYC‐associated B‐cell lymphoma – Giulio Donati, Micol Ravà, Marco Filipuzzi, Paola Nicoli, Laura Cassina, Alessandro Verrecchia, Mirko Doni, Simona Rodighiero, Federica Parodi, Alessandra Boletta, Christopher P. Vellano, Joseph R. Marszalek, Giulio F. Draetta, Bruno Amati. https://febs.onlinelibrary.wiley.com/doi/full/10.1002/1878-0261.13115

Mcl‐1 and Bcl‐xL levels predict responsiveness to dual MEK/Bcl‐2 inhibition in B‐cell malignancies – Katrine Melvold, Mariaserena Giliberto, Linda Karlsen, Pilar Ayuda-Durán, Robert Hanes, Toril Holien, Jorrit Enserink, Jennifer R. Brown, Geir E. Tjønnfjord, Kjetil Taskén, Sigrid S. Skånland. https://febs.onlinelibrary.wiley.com/doi/full/10.1002/1878-0261.13153

CRISPR activation screen identifies BCL-2 proteins and B3GNT2 as drivers of cancer resistance to T cell-mediated cytotoxicity – Julia Joung, Paul C. Kirchgatterer, Ankita Singh, Jang H. Cho, Suchita P. Nety, Rebecca C. Larson, Rhiannon K. Macrae, Rebecca Deasy, Yuen-Yi Tseng, Marcela V. Maus and Feng Zhang. https://www.nature.com/articles/s41467-022-29205-8


Death receptors


Potent pro-apoptotic combination therapy is highly effective in a broad range of cancers – Antonella Montinaro, Itziar Areso Zubiaur, Julia Saggau, Anna-Laura Kretz, Rute M. M. Ferreira, Omar Hassan, Ella Kitzig, Ines Müller, Mona A. El-Bahrawy, Silvia von Karstedt, Dagmar Kulms, Gianmaria Liccardi, Johannes Lemke and Henning Walczak. https://www.nature.com/articles/s41418-021-00869-x

Bacterial inhibition of Fas-mediated killing promotes neuroinvasion and persistence – Claire Maudet, Marouane Kheloufi, Sylvain Levallois, Julien Gaillard, Lei Huang, Charlotte Gaultier, Yu-Huan Tsai, Olivier Disson and Marc Lecuit. https://www.nature.com/articles/s41586-022-04505-7

Interferon-γ primes macrophages for pathogen ligand-induced killing via a caspase-8 and mitochondrial cell death pathway – Daniel S. Simpson, Jiyi Pang, Ashley Weir, Isabella Y. Kong, Melanie Fritsch, Maryam Rashidi, James P. Cooney, Kathryn C. Davidson, Mary Speir, Tirta M. Djajawi, Sebastian Hughes, Liana Mackiewicz, Merle Dayton, Holly Anderton, Marcel Doerflinger, Yexuan Deng, Allan Shuai Huang, Stephanie A. Conos, Hazel Tye, Seong H. Chow, Arfatur Rahman, Raymond S. Norton, Thomas Naderer, Sandra E. Nicholson, Gaetan Burgio, Si Ming Man, Joanna R. Groom, Marco J. Herold, Edwin D. Hawkins, Kate E. Lawlor, Andreas Strasser, John Silke, Marc Pellegrini, Hamid Kashkar, Rebecca Feltham, James E. Vince. https://www.cell.com/immunity/fulltext/S1074-7613(22)00032-2

Engineering adoptive T cell therapy to co-opt Fas ligand-mediated death signaling in ovarian cancer enhances therapeutic efficacy – Kristin G Anderson, Shannon K Oda, Breanna M Bates, Madison G Burnett, Magdalia Rodgers Suarez, Susan L Ruskin and Philip D Greenberg. https://jitc.bmj.com/content/10/3/e003959

Cancer cell-intrinsic resistance to BiTE therapy is mediated by loss of CD58 costimulation and modulation of the extrinsic apoptotic pathway – Ye Shen, Jason S Eng, Flordeliza Fajardo, Lingming Liang, Cong Li, Patrick Collins, Donato Tedesco and Olivier Nolan-Stevaux.  https://jitc.bmj.com/content/10/3/e004348


Caspases / IAPs


Caspase-8 has dual roles in regulatory T cell homeostasis balancing immunity to infection and collateral inflammatory damage – Charis E. Teh, Simon P. Preston, Alissa K. Robbins, Michael D. Stutz, James Cooney, Michelle P. Clark, Antonia N. Policheni, Cody C. Allison, Liana Mackiewicz, Philip Arandjelovic, Gregor Ebert, Marcel Doerflinger, Tania Tan, Lucille C. Rankin, Peggy P. Teh, Gabrielle T. Belz, Axel Kallies, Andreas Strasser, Marc Pellegrini, Daniel H. D. Gray. https://www.science.org/doi/abs/10.1126/sciimmunol.abn8041

Survivin is essential for thermogenic program and metabolic homeostasis in mice – Miriayi Alimujiang, Jingjing Sun, Shuqing Chen, Ningning Bai, Shuqin Chen, Fan Hu, Jingyuan Ma, Yuejie Xu, Jun Xu, Xiaojing Ma, Ying Yang. https://www.sciencedirect.com/science/article/pii/S2212877822000151

Therapeutic potential of Nlrp1 inflammasome, Caspase-1, or Caspase-6 against Alzheimer disease cognitive impairment – Joseph Flores, Anastasia Noël, Marie-Lyne Fillion and Andréa C. LeBlanc. https://www.nature.com/articles/s41418-021-00881-1


Pyroptosis


Fracture healing is delayed in the absence of gasdermin-interleukin-1 signaling – Kai Sun, Chun Wang, Jianqiu Xiao, Michael D Brodt, Luorongxin Yuan, Tong Yang, Yael Alippe, Huimin Hu, Dingjun Hao, Yousef Abu-Amer, Matthew J Silva, Jie Shen, Gabriel Mbalaviele . https://elifesciences.org/articles/75753


Ferroptosis


Kynurenine importation by SLC7A11 propagates anti-ferroptotic signaling – Alessandra Fiore, Leonie Zeitler, Marion Russier, Annette Groß, Maria-Kathrin Hiller, Joanne L. Parker, Luca Stier, Thomas Köcher, Simon Newstead, Peter J. Murray. https://www.cell.com/molecular-cell/fulltext/S1097-2765(22)00112-5

Ferroptosis induces membrane blebbing in placental trophoblasts – Kazuhiro Kajiwara, Ofer Beharier, Choon-Peng Chng, Julie P. Goff, Yingshi Ouyang, laudette M. St Croix, Changjin Huang, Valerian E. Kagan, K. Jimmy Hsia, Yoel Sadovsky. https://journals.biologists.com/jcs/article/135/5/jcs255737/224124/


Efferocytosis, immunogenicity


Live cell tracking of macrophage efferocytosis during Drosophila embryo development in vivo – Michael H. Raymond, Andrew J. Davidson, Yi Shen, Daniel R. Tudor, Christopher D. Lucas, Sho Morioka, Justin S. A. Perry, Julia Krapivkina, David Perrais, Linus J. Schumacher, Robert E. Campbell, Will Wood, Kodi S. Ravichandran. https://www.science.org/doi/abs/10.1126/science.abl4430

Cell death-induced immunogenicity enhances chemoimmunotherapeutic response by converting immune-excluded into T-cell inflamed bladder tumors – Fotis Nikolos, Kazukuni Hayashi, Xen Ping Hoi, Mark Ellie Alonzo, Qianxing Mo, Armine Kasabyan, Hideki Furuya, Jane Trepel, Dolores Di Vizio, Jlenia Guarnerio, Dan Theodorescu, Charles Rosser, Andrea Apolo, Matthew Galsky and Keith Syson Chan. https://www.nature.com/articles/s41467-022-29026-9


Phagoptosis


Knockout of the P2Y6 Receptor Prevents Peri-Infarct Neuronal Loss after Transient, Focal Ischemia in Mouse Brain – Stefan Milde and Guy C. Brown. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8879728/

Distinct roles in phagocytosis of the early and late increases of cell surface calreticulin induced by oxaliplatin – Kenju Matsusaka, Yutaro Azuma, Yuki Kaga, Saeka Uchida, Yuri Takebayashi, Takashi Tsuyama, Shusuke Tada. https://www.sciencedirect.com/science/article/pii/S2405580822000231

Phagocytosis and self-destruction break down dendrites of Drosophila sensory neurons at distinct steps of Wallerian degeneration – Hui Ji, Maria L Sapar, Ankita Sarkar, Bei Wang, Chun Han. https://www.pnas.org/doi/10.1073/pnas.2111818119


Miscellanous


Confined migration promotes cancer metastasis through resistance to anoikis and increased invasiveness – Deborah Fanfone, Zhichong Wu, Jade Mammi, Kevin Berthenet, David Neves, Kathrin Weber, Andrea Halaburkova, François Virard, Félix Bunel, Catherine Jamard, Hector Hernandez-Vargas, Stephen WG Tait, Ana Hennino, Gabriel Ichim. https://elifesciences.org/articles/73150

Copper induces cell death by targeting lipoylated TCA cycle proteins – Peter Tsvetkov, Shannon Coy, Boryana Petrova, Margaret Dreishpoon, Ana Verma, Mai Abdusamad, Jordan Rossen, Lena Joesch-Cohen, Ranad Humeidi, Ryan D. Spangler, John K. Eaton, Evgeni Frenkel, Mustafa Kocak, Steven M. Corsello, Svetlana Lutsenko, Naama Kanarek, Sandro Santagata, Todd R. Golub. https://www.science.org/doi/abs/10.1126/science.abf0529


Reviews


Tumor-intrinsic and immune modulatory roles of receptor-interacting protein kinases – Justin Rucker, Francis Ka-Ming Chan. https://www.cell.com/trends/biochemical-sciences/fulltext/S0968-0004(21)00273-5

Homing in on gasdermins: How fungi regulate cell death – Niklas A. Schmacke and Veit Hornung. https://www.pnas.org/doi/10.1073/pnas.2201192119?ai=aqle&ui=c8ih&af=T

Regulation of the release of damage-associated molecular patterns from necroptotic cells – Hiroyasu Nakano, Shin Murai, Kenta Moriwaki. https://portlandpress.com/biochemj/article-abstract/479/5/677/231045

Therapeutic approaches targeting CD95L/CD95 signaling in cancer and autoimmune diseases – Vesna Risso, Elodie Lafont and Matthieu Le Gallo. https://www.nature.com/articles/s41419-022-04688-x

Neuronal Loss after Stroke Due to Microglial Phagocytosis of Stressed Neurons – Guy C. Brown. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8707068/


Comments


The case for brakes: Why restrain the size of Bax and Bak pores in outer mitochondrial membranes? – David W. Andrews. https://www.cell.com/molecular-cell/fulltext/S1097-2765(22)00160-5

Copper-induced cell death – Martha A. Kahlson and Scott J. Dixon. https://www.science.org/doi/abs/10.1126/science.abo3959


Gordon Research Conference Cell Death.

Chair: Francis Chan. Vice Chair, Pascal Meier

Les Diablerets, Switzerland, May 15-20 2022. Application deadline April 22.

https://www.grc.org/cell-death-conference/2022

EWCD is ON this year in Fiuggi, Italy! 

Join us from June 26th – July 1st, 2022.

Abstract submission is open until April 8th but don’t wait, do it now 🙂    www.ewcd.eu

Looking forward to seeing faces again after 4 years!

ApoList – February 2022


Caspases and cFLIP


Executioner caspases 3 and 7 are dispensable for intestinal epithelium turnover and homeostasis at steady state – Farzaneh Ghazavi, Jelle Huysentruyt, Jordy De Coninck, Stephanie Kourula, Sofie Martens, Behrouz Hassannia, Tim Wartewig, Tatyana Divert, Ria Roelandt, Bastian Popper, Andreas Hiergeist, Peter Tougaard, Tom Vanden Berghe, Marie Joossens, Geert Berx, Nozomi Takahashi, Adam Wahida, and Peter Vandenabeele. https://www.pnas.org/content/119/6/e2024508119.abstract?etoc

cFLIP downregulation is an early event required for endoplasmic reticulum stress-induced apoptosis in tumor cells – Rocío Mora-Molina, Daniela Stöhr, Markus Rehm and Abelardo López-Rivas. https://www.nature.com/articles/s41419-022-04574-6

The deubiquitinase Usp27x as a novel regulator of cFIPL protein expression and sensitizer to death-receptor-induced apoptosis – Manuel Nico Dold, Xiulin Ng, Claudia Alber, Ian Edward Gentle, Georg Häcker, Arnim Weber. https://link.springer.com/article/10.1007/s10495-021-01706-9

Microfluidic deep mutational scanning of the human executioner caspases reveals differences in structure and regulation – Hridindu Roychowdury and Philip A. Romero. https://www.nature.com/articles/s41420-021-00799-0

Cell-to-cell variability in inducible Caspase9-mediated cell death – Yuan Yuan, Huixia Ren, Yanjun Li, Shanshan Qin, Xiaojing Yang and Chao Tang. https://www.nature.com/articles/s41419-021-04468-z

Blockade of caspase cascade overcomes malaria-associated acute respiratory distress syndrome in mice – Michelle K. Sercundes, Luana S. Ortolan, Viviane da Silva Julio, Leonardo M. Bella, Thatyane de Castro Quirino, Daniela Debone, Marcela S. Carneiro-Ramos, Marcelo A. Christoffolete, Joilson O. Martins, Maria Regina D’Império Lima, José M. Alvarez, Gustavo P. Amarante-Mendes, Lígia Antunes Gonçalves, Claudio R. F. Marinho and Sabrina Epiphanio. https://www.nature.com/articles/s41419-022-04582-6


Death receptors


Cell cycle progression and transmitotic apoptosis resistance promote escape from extrinsic apoptosis – Pollak N, Lindner A, Imig D, Kuritz K, Fritze JS, Decker L, Heinrich I, Stadager J, Eisler S, Allgöwer F, Scheurich P, Rehm M. https://journals.biologists.com/jcs/article/134/24/jcs258966/273757/Cell-cycle-progression-and-transmitotic-apoptosis | https://journals.biologists.com/jcs/article/134/24/jcs259602/273793/First-person-Nadine-Pollak

ER stress-induced cell death proceeds independently of the TRAIL-R2 signaling axis in pancreatic β cells – Cathrin Hagenlocher, Robin Siebert, Bruno Taschke, Senait Wieske, Angelika Hausser and Markus Rehm. https://www.nature.com/articles/s41420-022-00830-y

Focal adhesion kinase plays a dual role in TRAIL resistance and metastatic outgrowth of malignant melanoma – Greta Del Mistro, Shamala Riemann, Sebastian Schindler, Stefan Beissert, Roland E. Kontermann, Aurelien Ginolhac, Rashi Halder, Luana Presta, Lasse Sinkkonen, Thomas Sauter and Dagmar Kulms. https://www.nature.com/articles/s41419-022-04502-8


Necroptosis, RIPK


Site-specific ubiquitination of MLKL targets it to endosomes and targets Listeria and Yersinia to the lysosomes – Seongmin Yoon, Konstantin Bogdanov and David Wallach. https://www.nature.com/articles/s41418-021-00924-7

SMYD2 targets RIPK1 and restricts TNF-induced apoptosis and necroptosis to support colon tumor growth – Yu-qiang Yu, Veronika Thonn, Jay V. Patankar, Oana-Maria Thoma, Maximilian Waldner, Marta Zielinska, Li-li Bao, Miguel Gonzalez-Acera, Stefan Wallmüller, Felix B. Engel, Michael Stürzl, Markus F. Neurath, Eva Liebing and Christoph Becker. https://www.nature.com/articles/s41419-021-04483-0

Necroptosis triggers spatially restricted neutrophil-mediated vascular damage during lung ischemia reperfusion injury – Wenjun Li (et al) Ankit Bharat, and Daniel Kreisel. https://www.pnas.org/doi/10.1073/pnas.2111537119


Pyroptosis and gasdermins


Fungal gasdermin-like proteins are controlled by proteolytic cleavage – Corinne Clavé, Witold Dyrka, Elizabeth A. Turcotte, Alexandra Granger-Farbos, Léa Ibarlosa, Benoît Pinson, Russell E. Vance, Sven J. Saupe, and Asen Daskalov. https://www.pnas.org/content/119/7/e2109418119.abstract?etoc

Streptococcal pyrogenic exotoxin B cleaves GSDMA and triggers pyroptosis – Wanyan Deng, Yang Bai, Fan Deng, Youdong Pan, Shenglin Mei, Zengzhang Zheng, Rui Min, Zeyu Wu, Wu Li, Rui Miao, Zhibin Zhang, Thomas S. Kupper, Judy Lieberman and Xing Liu. https://www.nature.com/articles/s41586-021-04384-4

Electrostatic influence on IL-1 transport through the GSDMD pore – Wen Jun Xie, Shiyu Xia, Arieh Warshel, and Hao Wu. https://www.pnas.org/content/119/6/e2120287119.abstract?etoc

TRIM21 regulates pyroptotic cell death by promoting Gasdermin D oligomerization – Wenqing Gao, Yuanyuan Li, Xuehe Liu, Sen Wang, Pucheng Mei, Zijun Chen, Kewei Liu, Suhua Li, Xue-Wei Xu, Jianhua Gan, Jiaxue Wu, Chaoneng Ji, Chen Ding, Xing Liu, Yuping Lai, Housheng Hansen He, Judy Lieberman, Hao Wu, Xiangjun Chen and Jixi Li. https://www.nature.com/articles/s41418-021-00867-z

Epithelial Gasdermin D shapes the host-microbial interface by driving mucus layer formation – Jian Zhang, Qianzhou Yu, Danlu Jiang, Kang Yu, Weiwei Yu, Zhexu Chi, Sheng Chen, Mobai Li, Dehang Yang, Zhen Wang, Ting Xu, Xingchen Guo, Kailian Zhang, Hui Fang, Qizhen Ye, Yong He, Xue Zhang, Di Wang. https://www.science.org/doi/full/10.1126/sciimmunol.abk2092


Bcl-2 family proteins


Pediatric multicellular tumor spheroid models illustrate a therapeutic potential by combining BH3 mimetics with Natural Killer (NK) cell-based immunotherapy – Vinzenz Särchen, Senthan Shanmugalingam, Sarah Kehr, Lisa Marie Reindl, Victoria Greze, Sara Wiedemann, Cathinka Boedicker, Maureen Jacob, Katrin Bankov, Nina Becker, Sibylle Wehner, Till M. Theilen, Steffen Gretser, Elise Gradhand, Carsten Kummerow, Evelyn Ullrich and Meike Vogler. https://www.nature.com/articles/s41420-021-00812-6

MCL1 nuclear translocation induces chemoresistance in colorectal carcinoma – Dechen Fu, Luke Pfannenstiel, Abeba Demelash, Yee Peng Phoon, Cameron Mayell, Claudia Cabrera, Caini Liu, Junjie Zhao, Josephine Dermawan, Deepa Patil, Jennifer DeVecchio, Matthew Kalady, Andrew J. Souers, Darren C. Phillips, Xiaoxia Li and Brian Gastman. https://www.nature.com/articles/s41419-021-04334-y

DDX3 interacts with USP9X and participates in deubiquitination of the anti‐apoptotic protein MCL1 – Ming-Chih Lai, Yi-Pin Chen, Ding-An Li, Jau-Song Yu, Hsin-Yuan Hung, Woan-Yuh Tarn. https://febs.onlinelibrary.wiley.com/doi/abs/10.1111/febs.16219

BCL-XL inhibition induces an FGFR4-mediated rescue response in colorectal cancer – Prashanthi Ramesh, Simone Di Franco, Lidia Atencia Taboada, Le Zhang, Annalisa Nicotra, Giorgio Stassi, Jan Paul Medema. https://www.cell.com/cell-reports/fulltext/S2211-1247(22)00095-X

Clonal hematopoiesis, myeloid disorders and BAX-mutated myelopoiesis in patients receiving venetoclax for CLL – Piers Blombery, Thomas E. Lew, Michael A. Dengler, Ella R. Thompson, Victor S. Lin, Xiangting Chen, Tamia Nguyen, Ashish Panigrahi, Sasanka M. Handunnetti, Dennis A. Carney, David A. Westerman, Constantine S. Tam, Jerry M. Adams, Andrew H. Wei, David C. S. Huang, John F. Seymour, Andrew W. Roberts, Mary Ann Anderson. https://ashpublications.org/blood/article-abstract/139/8/1198/476749

The BCL-2 family member BOK promotes KRAS-driven lung cancer progression in a p53-dependent manner – Anna-Lena Meinhardt, Enkhtsetseg Munkhbaatar, Ulrike Höckendorf, Michelle Dietzen, Marta Dechant, Martina Anton, Anne Jacob, Katja Steiger, Wilko Weichert, Luka Brcic, Nicholas McGranahan, Caterina Branca, Thomas Kaufmann, Michael A. Dengler and Philipp J. Jost. https://www.nature.com/articles/s41388-021-02161-1

Non-canonical phosphorylation of Bmf by p38 MAPK promotes its apoptotic activity in anoikis – Zhe Zhi, Zhenlin Ouyang, Yibo Ren, Ying Cheng, Peijun Liu, Yurong Wen and Yongping Shao. https://www.nature.com/articles/s41418-021-00855-3

NOXA expression drives synthetic lethality to RUNX1 inhibition in pancreatic cancer – Josefina Doffo, Stefanos A. Bamopoulos (et al) and Matthias Wirth. https://www.pnas.org/doi/10.1073/pnas.2105691119


Ferroptosis


Targeting ferroptosis protects against experimental (multi)organ dysfunction and death – Samya Van Coillie, Emily Van San, Ines Goetschalckx, Bartosz Wiernicki, Banibrata Mukhopadhyay, Wulf Tonnus, Sze Men Choi, Ria Roelandt, Catalina Dumitrascu, Ludwig Lamberts, Geert Dams, Wannes Weyts, Jelle Huysentruyt, Behrouz Hassannia, Irina Ingold, Suhas Lele, Evelyne Meyer, Maya Berg, Ruth Seurinck, Yvan Saeys, An Vermeulen, Alexander L. N. van Nuijs, Marcus Conrad, Andreas Linkermann, Mohan Rajapurkar, Peter Vandenabeele, Eric Hoste, Koen Augustyns and Tom Vanden Berghe. https://www.nature.com/articles/s41467-022-28718-6

C-ferroptosis is an iron-dependent form of regulated cell death in cyanobacteria – Anabella Aguilera, Federico Berdun, Carlos Bartoli, Charlotte Steelheart, Matías Alegre, Hülya Bayir, Yulia Y. Tyurina, Valerian E. Kagan, Graciela Salerno, Gabriela Pagnussat, María Victoria Martin. https://rupress.org/jcb/article-abstract/221/2/e201911005/212878


Efferocytosis, entosis etc


Tumour cell apoptosis modulates the colorectal cancer immune microenvironment via interleukin-8-dependent neutrophil recruitment – Vanessa Schimek, Katharina Strasser, Andrea Beer, Samantha Göber, Natalie Walterskirchen, Christine Brostjan, Catharina Müller, Thomas Bachleitner-Hofmann, Michael Bergmann, Helmut Dolznig and Rudolf Oehler. https://www.nature.com/articles/s41419-022-04585-3

Autolysosomes and caspase-3 control the biogenesis and release of immunogenic apoptotic exosomes – Déborah Beillevaire, Francis Migneault, Julie Turgeon, Diane Gingras, Annie Karakeussian Rimbaud, Geneviève Marcoux, Crysta Spino, Nicolas Thibodeau, Eric Bonneil, Pierre Thibault, Éric Boilard, Mélanie Dieudé and Marie-Josée Hébert. https://www.nature.com/articles/s41419-022-04591-5

Necrotic debris and STING exert therapeutically relevant effects on tumor cholesterol homeostasis – Sampath Katakam, ProfileSantosh Anand, Patricia Martin, ProfileNicolo Riggi, ProfileIvan Stamenkovic. https://www.life-science-alliance.org/content/5/3/e202101256.abstract?etoc


Miscellanous


Functional visualization of NK cell-mediated killing of metastatic single tumor cells – Hiroshi Ichise, Shoko Tsukamoto, Tsuyoshi Hirashima, Yoshinobu Konishi, Choji Oki, Shinya Tsukiji, Satoshi Iwano, Atsushi Miyawaki, Kenta Sumiyama, Kenta Terai, Michiyuki Matsuda. https://elifesciences.org/articles/76269


Reviews


Regulation of extrinsic apoptotic signaling by c-FLIP: towards targeting cancer networks – Nikita V. Ivanisenko, Kamil Seyrek, Laura K. Hillert-Richter, Corinna König, Johannes Espe, Kakoli Bose, Inna N. Lavrik. https://www.cell.com/trends/cancer/fulltext/S2405-8033(21)00250-8

The concept of intrinsic versus extrinsic apoptosis – Laura Lossi. https://portlandpress.com/biochemj/article-abstract/479/3/357/230785

Double-edge sword roles of iron in driving energy production versus instigating ferroptosis – Shuping Zhang, Wei Xin, Gregory J. Anderson, Ruibin Li, Ling Gao, Shuguang Chen, Jiajun Zhao and Sijin Liu. https://www.nature.com/articles/s41419-021-04490-1

Collective effects in epithelial cell death and cell extrusion – Alexis Villars, Romain Levayer. https://www.sciencedirect.com/science/article/abs/pii/S0959437X21001106

Cell competition in vertebrates — a key machinery for tissue homeostasis – Takeshi Maruyama, Yasuyuki Fujita. https://www.sciencedirect.com/science/article/abs/pii/S0959437X2100118

Special issue Biochimica et Biophysica Acta (BBA) – Molecular Cell Research: “Death mechanisms in cellular homeostasis” Edited by Prof. Peter Ruvolo, Prof. Geert Bultynck. https://www.sciencedirect.com/journal/biochimica-et-biophysica-acta-bba-molecular-cell-research/special-issue/107S1CX8XZZ

Including, among others:

  • Cancer cell death strategies by targeting Bcl-2’s BH4 domain – Ian de Ridder, Martijn Kerkhofs, Santhini Pulikkal Veettil, Wim Dehaen, Geert Bultynck
  • It’s time to die: BH3 mimetics in solid tumors – Sarah Kehr, Meike Vogler
  • Death sentence: The tale of a fallen endoplasmic reticulum – Eoghan P. McGrath, Federica G. Centonze, Eric Chevet, Tony Avril, Elodie Lafont
  • Targeting epigenetic mechanisms to overcome venetoclax resistance – Gabriel Prado, Charlotte L. Kaestner, Jonathan D. Licht, Richard L. Bennett
  • Cell death as a result of calcium signaling modulation: A cancer-centric prospective – Alberto Danese, Sara Leo, Alessandro Rimessi, Mariusz R. Wieckowski, … Paolo Pinton

Persister cancer cells: Iron addiction and vulnerability to ferroptosis – Raphaël Rodriguez, Stuart L. Schreiber, Marcus Conrad. https://www.cell.com/molecular-cell/fulltext/S1097-2765(21)01038-8

Pyroptosis, a target for cancer treatment? – Ying Huang, Jian-Wei Wang, Jiao Huang, Lu Tang, Yun-Hua Xu, Hong Sun, Jie Tang, Guo Wang. https://link.springer.com/article/10.1007/s10495-021-01703-y


Comments


MLKL ubiquitylation: more than a makeover – Weihong Wang and Yi-Nan Gong. https://www.nature.com/articles/s41418-022-00934-z

A BAX door to venetoclax resistance – Franco Izzo, Dan A. Landau. https://ashpublications.org/blood/article/139/8/1124/484077/A-BAX-door-to-venetoclax-resistance

A lncRNA builds a glycolytic metabolon – Kim Baumann. https://www.nature.com/articles/s41580-022-00461-2


Conference:

EMBO Workshop “Dying in self-defense: cell death signaling in animals and plants”

Organized by Ana García and Panagiotis Moschou

1st – 5th May 2022 – Kalimera Kriti Hotel & Village Resort, Crete, Greece

https://meetings.embo.org/event/21-cell-death

ApoList – January 2022


Bcl-2 family proteins


BCL‐2‐family protein tBID can act as a BAX‐like effector of apoptosis – Hector Flores-Romero, Lisa Hohorst, Malina John, Marie-Christine Albert, Louise E King, Laura Beckmann, Tamas Szabo, Vanessa Hertlein, Xu Luo, Andreas Villunger, Lukas P Frenzel, Hamid Kashkar, Ana J Garcia-Saez. https://www.embopress.org/doi/full/10.15252/embj.2021108690

Structural basis of BAK activation in mitochondrial apoptosis initiation – Geetika Singh, Cristina D. Guibao and Tudor Moldoveanu. https://www.nature.com/articles/s41467-021-27851-y

Targeting Cpt1a-Bcl-2 interaction modulates apoptosis resistance and fibrotic remodeling – Linlin Gu, Ranu Surolia, Jennifer L. Larson-Casey, Chao He, Dana Davis, Jungsoon Kang, Veena B. Antony and A. Brent Carter. https://www.nature.com/articles/s41418-021-00840-w

The BCL-2 family member BOK promotes KRAS-driven lung cancer progression in a p53-dependent manner – Anna-Lena Meinhardt, Enkhtsetseg Munkhbaatar, Ulrike Höckendorf, Michelle Dietzen, Marta Dechant, Martina Anton, Anne Jacob, Katja Steiger, Wilko Weichert, Luka Brcic, Nicholas McGranahan, Caterina Branca, Thomas Kaufmann, Michael A. Dengler and Philipp J. Jost. https://www.nature.com/articles/s41388-021-02161-1


Efferocytosis, tissue homeostasis


Sensing plasma membrane pore formation induces chemokine production in survivors of regulated necrosis – Weihong Wang, Joshua S. Prokopec, Yixin Zhang, Maria Sukhoplyasova, Himaly Shinglot, Man-Tzu Wang, Andreas Linkermann, Jacob Stewart-Ornstein, Yi-Nan Gong. https://www.cell.com/developmental-cell/fulltext/S1534-5807(21)01035-2

Polyamine import and accumulation causes immunomodulation in macrophages engulfing apoptotic cells – Alexandra L. McCubbrey, Shannon A. McManus, Jazalle D. McClendon, Stacey M. Thomas, Hope B. Chatwin, Julie A. Reisz, Angelo D’Alessandro, Kara J. Mould, Donna L. Bratton, Peter M. Henson, William J. Janssen. https://www.cell.com/cell-reports/fulltext/S2211-1247(21)01726-5

Rapid lamellipodial responses by neighbor cells drive epithelial sealing in response to pyroptotic cell death – Alexis Bonfim-Melo, Ivar Noordstra, Shafali Gupta, Amy H. Chan, Mathew J.K. Jones, Kate Schroder, Alpha S. Yap. https://www.cell.com/cell-reports/fulltext/S2211-1247(22)00027-4


Caspases and IAPs


Drice restrains Diap2-mediated inflammatory signalling and intestinal inflammation – Christa Kietz, Aravind K. Mohan, Vilma Pollari, Ida-Emma Tuominen, Paulo S. Ribeiro, Pascal Meier and Annika Meinander. https://www.nature.com/articles/s41418-021-00832-w


Death receptors, necroptosis


Targeting necroptosis in muscle fibers ameliorates inflammatory myopathies – Mari Kamiya, Fumitaka Mizoguchi, Kimito Kawahata, Dengli Wang, Masahiro Nishibori, Jessica Day, Cynthia Louis, Ian P. Wicks, Hitoshi Kohsaka and Shinsuke Yasuda. https://www.nature.com/articles/s41467-021-27875-4


Pyroptosis


Bacterial gasdermins reveal an ancient mechanism of cell death – Alex G. Johnson, Tanita Wein, Megan L. Mayer, Brianna Duncan-Lowey, Erez Yirmiya, Yaara Oppenheimer-Shaanan, Gil Amitai, Rotem Sorek, Philip J. Kranzusch. https://www.science.org/doi/abs/10.1126/science.abj8432

GSDMB is increased in IBD and regulates epithelial restitution/repair independent of pyroptosis – Nitish Rana, Giuseppe Privitera, Hannah C. Kondolf, Katarzyna Bulek, Susana Lechuga, Carlo De Salvo, Daniele Corridoni, Agne Antanaviciute, Rebecca L. Maywald, Alexander M. Hurtado, Junjie Zhao, Emina H. Huang, Xiaoxia Li, E. Ricky Chan, Alison Simmons, Giorgos Bamias, Derek W. Abbott, Jason D. Heaney, Andrei I. Ivanov, Theresa T. Pizarro. https://www.cell.com/cell/fulltext/S0092-8674(21)01487-2

Gasdermin D pores are dynamically regulated by local phosphoinositide circuitry – Ana Beatriz Santa Cruz Garcia, Kevin P. Schnur and Gary C. H. Mo. https://www.nature.com/articles/s41467-021-27692-9

Streptococcal pyrogenic exotoxin B cleaves GSDMA and triggers pyroptosis – Wanyan Deng, Yang Bai, Fan Deng, Youdong Pan, Shenglin Mei, Zengzhang Zheng, Rui Min, Zeyu Wu, Wu Li, Rui Miao, Zhibin Zhang, Thomas S. Kupper, Judy Lieberman and Xing Liu. https://www.nature.com/articles/s41586-021-04384-4


Ferroptosis


Dexamethasone Sensitizes to Ferroptosis by Glucocorticoid Receptor-induced Dipeptidase-1 expression and Glutathione Depletion – von Mässenhausen A, Zamora Gonzalez N, Maremonti F, Belavgeni A, Tonnus W, Meyer C, Beer K, Hannani MT, Lau A, Peitzsch M, Hoppenz P, Locke S, Chavakis T, Kramann R, Muruve DA, Hugo C, Bornstein SR, Linkermann A. https://www.science.org/doi/10.1126/sciadv.abl8920

PKCβII phosphorylates ACSL4 to amplify lipid peroxidation to induce ferroptosis – Hai-Liang Zhang, Bing-Xin Hu, Zhi-Ling Li, Tian Du, Jia-Lu Shan, Zhi-Peng Ye, Xiao-Dan Peng, Xuan Li, Yun Huang, Xian-Ying Zhu, Yu-Hong Chen, Gong-Kan Feng, Dajun Yang, Rong Deng and Xiao-Feng Zhu. https://www.nature.com/articles/s41556-021-00818-3


Miscellanous


Senescence induction dictates response to chemo- and immunotherapy in preclinical models of ovarian cancer – Stella V. Paffenholz, Camilla Salvagno, Yu-Jui Ho, Matthew Limjoco, Timour Baslan, Sha Tian, Amanda Kulick, Elisa de Stanchina, John E. Wilkinson, Francisco M. Barriga, Dmitriy Zamarin, Juan R. Cubillos-Ruiz, Josef Leibold, and Scott W. Lowe. https://www.pnas.org/content/119/5/e2117754119.abstract?etoc

Bacillus anthracis induces NLRP3 inflammasome activation and caspase-8–mediated apoptosis of macrophages to promote lethal anthrax – Filip Van Hauwermeiren, Nina Van Opdenbosch, Hanne Van Gorp, Nathalia de Vasconcelos, Geert van Loo, Peter Vandenabeele, Thirumala-Devi Kanneganti, and Mohamed Lamkanfi. https://www.pnas.org/content/119/2/e2116415119.abstract


Reviews/comments


The complex interplay between autophagy and cell death pathways – Christina Ploumi, Margarita-Elena Papandreou, Nektarios Tavernarakis. https://portlandpress.com/biochemj/article-abstract/479/1/75/230651

The role of Ubiquitination in Apoptosis and Necroptosis – Jamie Z. Roberts, Nyree Crawford and Daniel B. Longley. https://www.nature.com/articles/s41418-021-00922-9

Cellular senescence: all roads lead to mitochondria – Hélène Martini, João F. Passos. https://febs.onlinelibrary.wiley.com/doi/full/10.1111/febs.16361#.Yfhngl2bq4U

Positive feedback amplifies ferroptosis – Jason Rodencal & Scott J. Dixon. https://www.nature.com/articles/s41556-021-00824-5

ApoList – December 2021


Bcl-2 family proteins


The BH3-only protein NOXA serves as an independent predictor of breast cancer patient survival and defines susceptibility to microtubule targeting agents – Gerlinde Karbon, Manuel D. Haschka, Hubert Hackl, Claudia Soratroi, Lourdes Rocamora-Reverte, Walther Parson, Heidelinde Fiegl and Andreas Villunger. https://www.nature.com/articles/s41419-021-04415-y

Oligodendrocytes depend on MCL-1 to prevent spontaneous apoptosis and white matter degeneration – Abigail H. Cleveland, Alejandra Romero-Morales, Laurent Alfonso Azcona, Melisa Herrero, Viktoriya D. Nikolova, Sheryl Moy, Orna Elroy-Stein, Vivian Gama and Timothy R. Gershon. https://www.nature.com/articles/s41419-021-04422-z


Death receptors


Bclaf1 regulates c-FLIP expression and protects cells from TNF-induced apoptosis and tissue injury – Rui Zhang, Teng Xue, Anwen Shao, Yue Lang, Chao Qin, Mingliang Zhao, Yu Kuang, Zhengquan Yu, Yunyun Geng, Chenyang Zhao, Jun Tang. https://www.embopress.org/doi/abs/10.15252/embr.202152702

Immune dysregulation in SHARPIN-deficient mice is dependent on CYLD-mediated cell death – Rosalind L. Ang, Mark Chan, Diana Legarda, John P. Sundberg, Shao-Cong Sun, Virginia L. Gillespie, Nicholas Chun, Peter S. Heeger, Huabao Xiong, Sergio A. Lira, and Adrian T. Ting. https://www.pnas.org/content/118/50/e2001602118.abstract?etoc


Caspases


Suppression of caspase 8 activity by a coronin 1–PI3Kδ pathway promotes T cell survival independently of TCR and IL-7 signaling – Mayumi Mori, Julie Ruer-Laventie, Wandrille Duchemin, Philippe Demougin, Tohnyui Ndinyanka Fabrice, Matthias P. Wymann, Jean Pieters. https://www.science.org/doi/abs/10.1126/scisignal.abj0057


Necroptosis / RIPK1


The role of RIPK1 mediated cell death in acute on chronic liver failure – Takayuki Kondo, Stewart Macdonald, Cornelius Engelmann, Abeba Habtesion, Jane Macnaughtan, Gautam Mehta, Rajeshwar P. Mookerjee, Nathan Davies, Marco Pavesi, Richard Moreau, Paolo Angeli, Vicente Arroyo, Fausto Andreola and Rajiv Jalan. https://www.nature.com/articles/s41419-021-04442-9

TNF-induced necroptosis initiates early autophagy events via RIPK3-dependent AMPK activation, but inhibits late autophagy – Wenxian Wu, Xiaojing Wang, Yadong Sun, Niklas Berleth, Jana Deitersen, David Schlütermann, Fabian Stuhldreier, Nora Wallot-Hieke, María José Mendiburo, Jan Cox, Christoph Peter, Ann Kathrin Bergmann and Björn Stork. https://www.tandfonline.com/doi/abs/10.1080/15548627.2021.1898748

RIPK1 dephosphorylation and kinase activation by PPP1R3G/PP1γ promote apoptosis and necroptosis – Jingchun Du, Yougui Xiang, Hua Liu, Shuzhen Liu, Ashwani Kumar, Chao Xing, Zhigao Wang. https://www.nature.com/articles/s41467-021-27367-5


Pyroptosis


Identification of an ASC oligomerization inhibitor for the treatment of inflammatory diseases – Paula M. Soriano-Teruel, Guillermo García‑Laínez, María Marco-Salvador, Julián Pardo, Maykel Arias, Christian DeFord, Irmgard Merfort, María J. Vicent, Pablo Pelegrín, Mónica Sancho and Mar Orzáez. https://www.nature.com/articles/s41419-021-04420-1

Strategies to package recombinant Adeno-Associated Virus expressing the N-terminal gasdermin domain for tumor treatment – Yuan Lu, Wenbo He and Gang Cao. https://www.nature.com/articles/s41467-021-27407-0


Efferocytosis, entosis, phagoptosis


Efferocytosis induces macrophage proliferation to help resolve tissue injury – Brennan D. Gerlach, Patrick B. Ampomah, Arif Yurdagul Jr., Chuang Liu, Max C. Lauring, Xiaobo Wang, Canan Kasikara, Na Kong, Jinjun Shi, Wei Tao, Ira Tabas. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(21)00527-1

The microglial P2Y6 receptor mediates neuronal loss and memory deficits in neurodegeneration – Puigdellívol M, Milde S, Vilalta A, Cockram TOJ, Allendorf DH, Lee JY, Dundee JM, Pampuščenko K, Borutaite V, Nuthall HN, Brelstaff JH, Spillantini MG, Brown GC. https://www.sciencedirect.com/science/article/pii/S2211124721016442

Inflammatory neuronal loss in the substantia nigra induced by systemic lipopolysaccharide is prevented by knockout of the P2Y6 receptor in mice – Milde S, van Tartwijk FW, Vilalta A, Hornik TC, Dundee JM, Puigdellívol M, Brown GC. https://jneuroinflammation.biomedcentral.com/articles/10.1186/s12974-021-02280-2


Miscellanous


Identification of the BCL2/adenovirus E1B-19K protein-interacting protein 2 (BNIP-2) as a granzyme B target during human natural killer cell-mediated killing – Gina B. Scott, Paul A. Bowles, Erica B. Wilson, Josephine L. Meade, Boon Chuan Low, Adam Davison, G. Eric Blair, Graham P. Cook. https://portlandpress.com/biochemj/article-abstract/431/3/423/45170


Reviews


The evolution of regulated cell death pathways in animals and their evasion by pathogens – Bart Tummers, Douglas R Green. https://journals.physiology.org/doi/abs/10.1152/physrev.00002.2021

The manipulation of apoptosis for cancer therapy using BH3-mimetic drugs – Sarah T. Diepstraten, Mary Ann Anderson, Peter E. Czabotar, Guillaume Lessene, Andreas Strasser and Gemma L. Kelly. https://www.nature.com/articles/s41568-021-00407-4

Impact of human CD95 mutations on cell death and autoimmunity: a model – Kamil Seyrek, Nikita V. Ivanisenko, Fabian Wohlfromm, Johannes Espe, Inna N. Lavrik. https://www.cell.com/trends/immunology/fulltext/S1471-4906(21)00242-8

Physiological and pharmacological modulation of BAX – Adam Z. Spitz, Evripidis Gavathiotis. https://www.cell.com/trends/pharmacological-sciences/fulltext/S0165-6147(21)00216-9

The role of caspases as executioners of apoptosis – Sharad Kumar, Loretta Dorstyn, Yoon Lim. https://portlandpress.com/biochemsoctrans/article/doi/10.1042/BST20210751/230566

Immunogenic ferroptosis and where to find it? – Robin Demuynck, Iuliia Efimova, Faye Naessens and Dmitri V Krysko. https://jitc.bmj.com/content/9/12/e003430

Necroptosis and tumor progression – Jiong Yan, Peixing Wan, Swati Choksi, Zheng-Gang Liu. https://www.cell.com/trends/cancer/fulltext/S2405-8033(21)00193-X

Killing by Degradation: Regulation of Apoptosis by the Ubiquitin-Proteasome-System – Ruqaia Abbas and Sarit Larisch. https://www.mdpi.com/2073-4409/10/12/3465

I’m Infected, Eat Me! Innate Immunity Mediated by Live, Infected Cells Signaling To Be Phagocytosed – Birkle T, Brown GC. https://journals.asm.org/doi/10.1128/IAI.00476-20

Neuronal Loss after Stroke Due to Microglial Phagocytosis of Stressed Neurons – Brown GC. https://www.mdpi.com/1422-0067/22/24/13442

The Phagocytic Code Regulating Phagocytosis of Mammalian Cells – Cockram TO, Dundee JM, Popescu AS, Brown GC. https://www.frontiersin.org/articles/10.3389/fimmu.2021.629979/full

Microglial phagocytosis of neurons in neurodegeneration, and its regulation – Butler CA, Popescu AS, Kitchener EJ, Allendorf DH, Puigdellívol M, Brown GC. https://onlinelibrary.wiley.com/doi/10.1111/jnc.15327

In conversation with Christine Watson – Paraminder Dhillon, Christine J. Watson. https://febs.onlinelibrary.wiley.com/doi/full/10.1111/febs.16071

ApoList – November 2021


Caspases and IAPs


Caspase-2 regulates S-phase cell cycle events to protect from DNA damage accumulation independent of apoptosis – Ashley G. Boice, Karla E. Lopez, Raj K. Pandita, Melissa J. Parsons, Chloe I. Charendoff, Vijay Charaka, Alexandre F. Carisey, Tej K. Pandita and Lisa Bouchier-Hayes. https://www.nature.com/articles/s41388-021-02085-w
XIAP restrains TNF-driven intestinal inflammation and dysbiosis by promoting innate immune responses of Paneth and dendritic cells – Adam Wahida, Madeleine Müller, Andreas Hiergeist, Bastian Popper, Katja Steiger, Caterina Branca, Markus Tschurtschenthaler, Thomas Engleitner, Sainitin Donakonda, Jordy De Coninck, Rupert Öllinger, Marie K. Pfautsch, Nicole Müller, Miguel Silva, Sinem Usluer, Erik Thiele Oberg, Jan P. Böttcher, Nicole Pfarr, Martina Anton, Julia B. Slotta-Huspenina, Andreas G. Nerlich, Tobias Madl, Marijana Basic, André Bleich, Geert Berx, Jürgen Ruland, Percy A. Knolle, Roland Rad, Timon E. Adolph, Peter Vandenabeele, Hirokazu Kanegane, André Gessner, Philipp J. Jost, Monica Yabal. https://www.science.org/doi/full/10.1126/sciimmunol.abf7235
Deficiency in X-linked inhibitor of apoptosis protein promotes susceptibility to microbial triggers of intestinal inflammation – Anne Strigli, Shreya Gopalakrishnan, Yvonne Zeissig, Marijana Basic, Jun Wang, Tobias Schwerd, Shauni Doms, Kenneth Peuker, Jelka Hartwig, Jürgen Harder, Pia Hönscheid, Philipp Arnold, Thomas Kurth, Fabian Rost, Britt-Sabina Petersen, Michael Forster, Andre Franke, Judith R. Kelsen, Meino Rohlfs, Christoph Klein, Aleixo M. Muise, Neil Warner, Ryusuke Nambu, Julia Mayerle, Helga-Paula Török, Andreas Linkermann, Michael H. Muders, Gustavo B. Baretton, Jochen Hampe, Daniela E. Aust, John F. Baines, André Bleich, Sebastian Zeissig. https://www.science.org/doi/full/10.1126/sciimmunol.abf7473
SMAC/Diablo controls proliferation of cancer cells by regulating phosphatidylethanolamine synthesis – Swaroop Kumar Pandey, Avijit Paul, Anna Shteinfer-Kuzmine, Ran Zalk, Uwe Bunz, Varda Shoshan-Barmatz. https://febs.onlinelibrary.wiley.com/doi/full/10.1002/1878-0261.12959


Efferocytosis, entosis, cell-cell


Apoptotic stress-induced FGF signalling promotes non-cell autonomous resistance to cell death – Florian J. Bock, Egor Sedov, Elle Koren, Anna L. Koessinger, Catherine Cloix, Désirée Zerbst, Dimitris Athineos, Jayanthi Anand, Kirsteen J. Campbell, Karen Blyth, Yaron Fuchs and Stephen W. G. Tait. https://www.nature.com/articles/s41467-021-26613-0
TRAIL signaling promotes entosis in colorectal cancer – Emir Bozkurt; Heiko Düssmann; Manuela Salvucci; Brenton L. Cavanagh ; Sandra Van Schaeybroeck; Daniel B. Longley; Seamus J. Martin; Jochen H.M. Prehn. https://rupress.org/jcb/article-abstract/220/11/e202010030/212649
Human intestinal and circulating invariant natural killer T cells are cytotoxic against colorectal cancer cells via the perforin–granzyme pathway – Angélica Díaz-Basabe, Claudia Burrello, Georgia Lattanzi, Fiorenzo Botti, Alberto Carrara, Elisa Cassinotti, Flavio Caprioli, Federica Facciotti. https://febs.onlinelibrary.wiley.com/doi/full/10.1002/1878-0261.13104


Death receptors


HOIP limits anti‐tumor immunity by protecting against combined TNF and IFN‐gamma‐induced apoptosis – Andrew J Freeman, Stephin J Vervoort, Jessica Michie, Kelly M Ramsbottom, John Silke, Conor J Kearney, Jane Oliaro. https://www.embopress.org/doi/abs/10.15252/embr.202153391
A patch of positively charged residues regulates the efficacy of clinical DR5 antibodies in solid tumors – Gururaj Shivange, Tanmoy Mondal, Evan Lyerly, Sanchita Bhatnagar, Charles N. Landen, Shivani Reddy, Jonathan Kim, Britney Doan, Paula Riddle, Jogender Tushir-Singh. https://www.cell.com/cell-reports/fulltext/S2211-1247(21)01430-3
A comprehensive interaction study provides a potential domain interaction network of human death domain superfamily proteins – Wei Zhou, Naoe Kaneko, Tomoya Nakagita, Hiroyuki Takeda and Junya Masumoto. https://www.nature.com/articles/s41418-021-00796-x
TRAIL/DR5 pathway promotes AKT phosphorylation, skeletal muscle differentiation, and glucose uptake – Barbara Toffoli, Federica Tonon, Veronica Tisato, Giorgio Zauli, Paola Secchiero, Bruno Fabris and Stella Bernardi. https://www.nature.com/articles/s41419-021-04383-3


Necroptosis, RIP kinases, MLKL


Oligomerization‐driven MLKL ubiquitylation antagonizes necroptosis – Zikou Liu, Laura F Dagley, Kristy Shield-Artin, Samuel N Young, Aleksandra Bankovacki, Xiangyi Wang, Michelle Tang, Jason Howitt, Che A Stafford, Ueli Nachbur, Cheree Fitzgibbon, Sarah E Garnish, Andrew I Webb, David Komander, James M Murphy, Joanne M Hildebrand, John Silke. https://www.embopress.org/doi/abs/10.15252/embj.2019103718
Human RIPK3 maintains MLKL in an inactive conformation prior to cell death by necroptosis – Yanxiang Meng, Katherine A. Davies and James M. Murphy. https://www.nature.com/articles/s41467-021-27032-x
MLKL promotes cellular differentiation in myeloid leukemia by facilitating the release of G-CSF – Xin Wang, Uris Ros, Deepti Agrawal, Eva C. Keller, Julia Slotta-Huspenina, Veronika Dill, Bo Shen, Run Shi, Tobias Herold, Claus Belka, Ritu Mishra, Florian Bassermann, Ana J. Garcia-Saez and Philipp J. Jost. https://www.nature.com/articles/s41418-021-00811-1
Caspase‐9 acts as a regulator of necroptotic cell death – Tamás Molnár, Petra Pallagi, Bálint Tél, Róbert Király, Eszter Csoma, Viktória Jenei, Zsófia Varga, Péter Gogolák, Anne Odile Hueber, Zoltán Máté, Ferenc Erdélyi, Gábor Szabó, Aladár Pettkó-Szandtner, Attila Bácsi, László Virág, József Maléth, Gábor Koncz. https://febs.onlinelibrary.wiley.com/doi/full/10.1111/febs.15898
Quantitative analysis of phosphoproteome in necroptosis reveals a role of TRIM28 phosphorylation in promoting necroptosis-induced cytokine production – Rui Zu, Zhen Yu, Jing Zhao, Xiaojuan Lu, Wei Liang, Le Sun, Chenfang Si, Kezhou Zhu, Tian Zhang, Ganquan Li, Mengmeng Zhang, Yaoyang Zhang, Nan Liu, Junying Yuan and Bing Shan. https://www.nature.com/articles/s41419-021-04290-7
Genetic inhibition of RIPK3 ameliorates functional outcome in controlled cortical impact independent of necroptosis – Limin Wu, Joon Yong Chung, Tian Cao, Gina Jin, William J. Edmiston III, Suzanne Hickman, Emily S. Levy, Jordyn A. Whalen, Eliza Sophie LaRovere Abrams, Alexei Degterev, Eng H. Lo, Lorenzo Tozzi, David L. Kaplan, Joseph El Khoury and Michael J. Whalen. https://www.nature.com/articles/s41419-021-04333-z
Proteomic analysis of necroptotic extracellular vesicles – Inbar Shlomovitz, Ziv Erlich, Gali Arad, Liat Edry-Botzer, Sefi Zargarian, Hadar Cohen, Tal Manko, Yifat Ofir-Birin, Tomer Cooks, Neta Regev-Rudzki and Motti Gerlic. https://www.nature.com/articles/s41419-021-04317-z


Reviews


Molecular mechanisms and functions of pyroptosis in inflammation and antitumor immunity – Junwei Hou, Jung-Mao Hsu, Mien-Chie Hung. https://www.cell.com/molecular-cell/fulltext/S1097-2765(21)00737-1
Soluble CD95L in cancers and chronic inflammatory disorders, a new therapeutic target? – Keerthi Kurma, Andrea Boizard-Moracchini, Gael Galli, Mickael Jean, Pierre Vacher, Patrick Blanco, Patrick Legembre. https://www.sciencedirect.com/science/article/abs/pii/S0304419X21000937
First we eat, then we do everything else: The dynamic metabolic regulation of efferocytosis – Alissa Trzeciak, Ya-Ting Wang, Justin Shaun Arnold Perry. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(21)00364-8
Apoptotic cell-derived metabolites in efferocytosis-mediated resolution of inflammation – Yiwei Mao. https://www.sciencedirect.com/science/article/abs/pii/S1359610121000745
Dying cells fan the flames of inflammation – Kim Newton, Vishva M. Dixit, Nobuhiko Kayagaki. https://www.science.org/doi/10.1126/science.abi5934#.YaAPliOd4NI


Comments


Cell death leaves a new TRAIL – Michael Overholtzer. https://rupress.org/jcb/article/220/11/e202109018/212699
In Conversation with Tony Letai – Eleni Skourti, Anthony Letai. https://febs.onlinelibrary.wiley.com/doi/full/10.1111/febs.16229
Editor Profile: Eli Arama. https://febs.onlinelibrary.wiley.com/doi/full/10.1111/febs.15902
Bcl-xL and IP3R interaction: Intimate relationship with an uncertain outcome – Nikolay Popgeorgieva, Germain Gillet. https://www.sciencedirect.com/science/article/abs/pii/S0143416021001585


Bcl-2 family proteins


Bcl-xL acts as an inhibitor of IP3R channels, thereby antagonizing Ca2+-driven apoptosis – Nicolas Rosa, Hristina Ivanova, Larry E. Wagner 2nd, Justin Kale, Rita La Rovere, Kirsten Welkenhuyzen, Nikolaos Louros, Spyridoula Karamanou, Victoria Shabardina, Irma Lemmens, Elien Vandermarliere, Kozo Hamada, Hideaki Ando, Frederic Rousseau, Joost Schymkowitz, Jan Tavernier, Katsuhiko Mikoshiba, Anastassios Economou, David W. Andrews, Jan B. Parys, David I. Yule and Geert Bultynck. https://www.nature.com/articles/s41418-021-00894-w
BH3-only proteins Puma and Beclin1 regulate autophagic death in neurons in response to Amyloid-β – Akash Saha, Suraiya Saleem, Paidi Ramesh Kumar and Subhas C. Biswas. https://www.nature.com/articles/s41420-021-00748-x
The BAX-binding protein MOAP1 associates with LC3 and promotes closure of the phagophore – Hao-Chun Chang, Ran N. Tao, Chong Teik Tan, Ya Jun Wu, Boon Huat Bay and Victor C. Yu. https://www.tandfonline.com/doi/full/10.1080/15548627.2021.1896157
Venetoclax imparts distinct cell death sensitivity and adaptivity patterns in T cells – Lindsey M. Ludwig, Katrina M. Hawley, David B. Banks, Anika T. Thomas-Toth, Bruce R. Blazar, Megan E. McNerney, Joel D. Leverson and James L. LaBelle. https://www.nature.com/articles/s41419-021-04285-4
Development of a BCL-xL and BCL-2 dual degrader with improved anti-leukemic activity – Dongwen Lv, Pratik Pal, Xingui Liu, Yannan Jia, Dinesh Thummuri, Peiyi Zhang, Wanyi Hu, Jing Pei, Qi Zhang, Shuo Zhou, Sajid Khan, Xuan Zhang, Nan Hua, Qingping Yang, Sebastian Arango, Weizhou Zhang, Digant Nayak, Shaun K. Olsen, Susan T. Weintraub, Robert Hromas, Marina Konopleva, Yaxia Yuan, Guangrong Zheng and Daohong Zhou. https://www.nature.com/articles/s41467-021-27210-x
Paradoxical implication of BAX/BAK in the persistence of tetraploid cells – Jiayin Deng, Lucía G. Gutiérrez, Gautier Stoll, Omar Motiño, Isabelle Martins, Lucía Núñez, José Manuel Bravo-San Pedro, Juliette Humeau, Chloé Bordenave, Juncheng Pan, Hélène Fohrer-Ting, Sylvie Souquere, Gerard Pierron, Claudio Hetz, Carlos Villalobos, Guido Kroemer and Laura Senovilla. https://www.nature.com/articles/s41419-021-04321-3
UBQLN4 is an ATM substrate that stabilizes the anti‐apoptotic proteins BCL2A1 and BCL2L10 in mesothelioma – Fang Liu, RunSang Pan, HongYu Ding, LiLing Gu, Yun Yang, ChuanYin Li, YongJie Xu, Ronggui Hu, Hui Chen, XiangYan Zhang, YingJie Nie. https://febs.onlinelibrary.wiley.com/doi/full/10.1002/1878-0261.13058
BAX mitochondrial integration is regulated allosterically by its α1−α2 loop – Michael A. Dengler, Leonie Gibson and Jerry M. Adams. https://www.nature.com/articles/s41418-021-00815-x


Pyroptosis


Gasdermin D mediates host cell death bu not interleukin-1β secretion in Mycobacterium tuberculosis-infected macrophages – Sebastian J. Theobald, Jessica Gräb, Melanie Fritsch, Isabelle Suárez, Hannah S. Eisfeld, Sandra Winter, Maximilian Koch, Christoph Hölscher, Manolis Pasparakis, Hamid Kashkar and Jan Rybniker. https://www.nature.com/articles/s41420-021-00716-5

ApoList – October 2021


Bcl-2 family proteins


Dynamic reconfiguration of pro‐apoptotic BAK on membranes – Jarrod J Sandow, Iris KL Tan, Alan S Huang, Shashank Masaldan, Jonathan P Bernardini, Ahmad Z Wardak, Richard W Birkinshaw, Robert L Ninnis, Ziyan Liu, Destiny Dalseno, Daisy Lio, Giuseppi Infusini, Peter E Czabotar, Andrew I Webb, Grant Dewson. https://www.embopress.org/doi/abs/10.15252/embj.2020107237

High‐resolution analysis of the conformational transition of pro‐apoptotic Bak at the lipid membrane – Laura E Sperl, Florian Rührnößl, Anita Schiller, Martin Haslbeck, Franz Hagn. https://www.embopress.org/doi/full/10.15252/embj.2020107159

The anti‐apoptotic Bcl‐2 protein regulates hair follicle stem cell function – Anna Geueke, Giada Mantellato, Florian Kuester, Peter Schettina, Melanie Nelles, Jens Michael Seeger, Hamid Kashkar, Catherin Niemann. https://www.embopress.org/doi/full/10.15252/embr.202052301

Genome-wide mRNA profiling identifies X-box-binding protein 1 (XBP1) as an IRE1 and PUMA repressor – Magdalena Gebert, Aleksandra Sobolewska, Sylwia Bartoszewska, Aleksandra Cabaj, David K. Crossman, Jarosław Króliczewski, Piotr Madanecki, Michał Dąbrowski, James F. Collawn and Rafal Bartoszewski. https://link.springer.com/article/10.1007%2Fs00018-021-03952-1

Fatty acid synthase (FASN) regulates the mitochondrial priming of cancer cells – Barbara Schroeder, Travis Vander Steen, Ingrid Espinoza, Chandra M. Kurapaty Venkatapoorna, Zeng Hu, Fernando Martín Silva, Kevin Regan, Elisabet Cuyàs, X. Wei Meng, Sara Verdura, Aina Arbusà, Paula A. Schneider, Karen S. Flatten, George Kemble, Joan Montero, Scott H. Kaufmann, Javier A. Menendez and Ruth Lupu. https://www.nature.com/articles/s41419-021-04262-x

MCL-1 Inhibition Overcomes Anti-apoptotic Adaptation to Targeted Therapies in B-Cell Precursor Acute Lymphoblastic Leukemia – Albert Manzano-Muñoz, Clara Alcon, Pablo Menéndez, Manuel Ramírez, Felix Seyfried, Klaus-Michael Debatin, Lüder H. Meyer, Josep Samitier and Joan Montero. https://www.frontiersin.org/articles/10.3389/fcell.2021.695225/full

Doxorubicin-induced novel circRNA_0004674 facilitates osteosarcoma progression and chemoresistance by upregulating MCL1 through miR-142-5p – Xiao-Long Ma, Tai-Cheng Zhan, Jian-Ping Hu, Chun-Lin Zhang and Kun-Peng Zhu. https://www.nature.com/articles/s41420-021-00698-4

SNAI2-Mediated Repression of BIM Protects Rhabdomyosarcoma from Ionizing Radiation – Long Wang, Nicole R. Hensch, Kathryn Bondra, Prethish Sreenivas, Xiang R. Zhao, Jiangfei Chen, Rodrigo Moreno Campos, Kunal Baxi, Angelina V. Vaseva, Benjamin D. Sunkel, Berkley E. Gryder, Silvia Pomella, Benjamin Z. Stanton, Siyuan Zheng, Eleanor Y. Chen, Rossella Rota, Javed Khan, Peter J. Houghton and Myron S. Ignatius. https://cancerres.aacrjournals.org/content/81/21/5451


Death receptors


Phosphoproteome profiling uncovers a key role for CDKs in TNF signaling – Maria C. Tanzer, Isabell Bludau, Che A. Stafford, Veit Hornung and Matthias Mann. https://www.nature.com/articles/s41467-021-26289-6

HSPA13 facilitates NF-κβ-mediated transcription and attenuates cell death responses in TNFα signaling – Chun Gao, Jianhua Deng, Hanchenxi Zhang, Xinran Li, Shuchen Gu, Mingjie Zheng, Mei Tang, Yezhang Zhu, Xin Lin, Jianping Jin, Long Zhang, Jun Huang, Jian Zou, Zong-Ping Xia, Ping-Long Xu, Li Shen, Bin Zhao, Xin-Hua Feng. https://www.science.org/doi/full/10.1126/sciadv.abh1756

FAIM regulates autophagy through glutaminolysis in lung adenocarcinoma – Tianyu Han, Pengcheng Wang, Yanan Wang, Wenze Xun, Jiapeng Lei, Tao Wang, Zhuo Lu, Mingxi Gan, Wei Zhang, Bentong Yu and Jian-Bin Wang. https://www.tandfonline.com/doi/full/10.1080/15548627.2021.1987672


Caspases, RIPK1


RIPK1 regulates starvation resistance by modulating aspartate catabolism – Xinyu Mei, Yuan Guo, Zhangdan Xie, Yedan Zhong, Xiaofen Wu, Daichao Xu, Ying Li, Nan Liu and Zheng-Jiang Zhu. https://www.nature.com/articles/s41467-021-26423-4

Environmental allergens trigger type 2 inflammation through ripoptosome activation – Michael Brusilovsky, Mark Rochman, Yrina Rochman, Julie M. Caldwell, Lydia E. Mack, Jennifer M. Felton, Jeff E. Habel, Aleksey Porollo, Chandrashekhar Pasare and Marc E. Rothenberg. https://www.nature.com/articles/s41590-021-01011-2


Necroptosis


ZBP1-MLKL necroptotic signaling potentiates radiation-induced antitumor immunity via intratumoral STING pathway activation – Yuanqin Yang, Meng Wu, Dongqing Cao, Chao Yang, Jingsi Jin, Lingling Wu, Xiaochuan Hong, Wenwen Li, Lu Lu, Jinmei Li, Xinran Wang, Xiangjiao Meng, Zhen Zhang, Jinke Cheng, Youqiong Ye, Hui Xiao, Jinming Yu, Liufu Deng. https://www.science.org/doi/full/10.1126/sciadv.abf6290

OTULIN inhibits RIPK1-mediated keratinocyte necroptosis to prevent skin inflammation in mice – Hannah Schünke, Ulrike Göbel, Ivan Dikic and Manolis Pasparakis. https://www.nature.com/articles/s41467-021-25945-1


Pyroptosis, inflammation


Shigella evades pyroptosis by arginine ADP-riboxanation of caspase-11 – Zilin Li, Wang Liu, Jiaqi Fu, Sen Cheng, Yue Xu, Zhiqiang Wang, Xiaofan Liu, Xuyan Shi, Yaxin Liu, Xiangbing Qi, Xiaoyun Liu, Jingjin Ding and Feng Shao. https://www.nature.com/articles/s41586-021-04020-1

Caspase-8 Is a Linchpin in Caspase-3 and Gasdermin D Activation to Control Cell Death, Cytokine Release, and Host Defense during Influenza A Virus Infection – Yaqiu Wang, Rajendra Karki, Min Zheng, Balabhaskararao Kancharana, SangJoon Lee, Sannula Kesavardhana, Baranda S Hansen, Shondra M Pruett-Miller, Thirumala-Devi Kanneganti.. https://www.jimmunol.org/content/early/2021/10/18/jimmunol.2100757.long

OTULIN maintains skin homeostasis by controlling keratinocyte death and stem cell identity – Esther Hoste, Kim Lecomte, Karl Annusver, Niels Vandamme, Jana Roels, Sophia Maschalidi, Lien Verboom, Hanna-Kaisa Vikkula, Mozes Sze, Lisette Van Hove, Kevin Verstaen, Arne Martens, Tino Hochepied, Yvan Saeys, Kodi Ravichandran, Maria Kasper and Geert van Loo. https://www.nature.com/articles/s41467-021-25944-2

NLRP3 inflammasome activation triggers gasdermin D-independent inflammation – Chun Wang, Tong Yang, Jianqiu Xiao, Canxin Xu, Yael Alippe, Kai Sun, Thirumala-Devi Kanneganti, Joseph B. Monahan, Yousef Abu-Amer, Judy Lieberman, Gabriel Mbalaviele. https://www.science.org/doi/abs/10.1126/sciimmunol.abj3859


Efferocytosis – inflammation


eccDNAs are apoptotic products with high innate immunostimulatory activity – Yuangao Wang, Meng Wang, Mohamed Nadhir Djekidel, Huan Chen, Di Liu, Frederick W. Alt and Yi Zhang. https://www.nature.com/articles/s41586-021-04009-w

Attenuation of apoptotic cell detection triggers thymic regeneration after damage – Sinéad Kinsella, Cindy A. Evandy, Kirsten Cooper, Lorenzo Iovino, Paul C. deRoos, Kayla S. Hopwo, David W. Granadier, Colton W. Smith, Shahin Rafii, Jarrod A. Dudakov. https://www.cell.com/cell-reports/fulltext/S2211-1247(21)01248-1


Miscellanous


Mitochondrial translation is required for sustained killing by cytotoxic T cells – Miriam Lisci, Philippa R. Barton, Lyra O. Randzavola, Claire Y. Ma, Julia M. Marchingo, Doreen A. Cantrell, Vincent Paupe, Julien Prudent, Jane C. Stinchcombe, Gillian M. Griffiths. https://www.science.org/doi/10.1126/science.abe9977

Neurotoxic reactive astrocytes induce cell death via saturated lipids – Kevin A. Guttenplan, Maya K. Weigel, Priya Prakash, Prageeth R. Wijewardhane, Philip Hasel, Uriel Rufen-Blanchette, Alexandra E. Münch, Jacob A. Blum, Jonathan Fine, Mikaela C. Neal, Kimberley D. Bruce, Aaron D. Gitler, Gaurav Chopra, Shane A. Liddelow and Ben A. Barres. https://www.nature.com/articles/s41586-021-03960-y

Lysosomal Zn2+ release triggers rapid, mitochondria-mediated, non-apoptotic cell death in metastatic melanoma – Wanlu Du, Mingxue Gu, Meiqin Hu, Prateeksunder Pinchi, Wei Chen, Michael Ryan, Timothy Nold, Ahmed Bannaga, Haoxing Xu. https://www.cell.com/cell-reports/fulltext/S2211-1247(21)01312-7

Cell death inhibitors protect against brain damage caused by cardiac ischemia/reperfusion injury – Suchan Liao, Nattayaporn Apaijai, Ying Luo, Jun Wu, Titikorn Chunchai, Kodchanan Singhanat, Busarin Arunsak, Juthipong Benjanuwattra, Nipon Chattipakorn and Siriporn C. Chattipakorn. https://www.nature.com/articles/s41420-021-00698-4

Protein Signatures of NK Cell–Mediated Melanoma Killing Predict Response to Immunotherapies – Sabrina Cappello, Hsu-Min Sung, Christian Ickes, Christine S. Gibhardt, Adina Vultur, Hilal Bhat, Zhongwen Hu, Patricia Brafford, Andreas Denger, Ioana Stejerean-Todoran, Rixa-Mareike Köhn, Verena Lorenz, Nicolas Künzel, Gabriela Salinas, Hedwig Stanisz, Tobias Legler, Peter Rehling, Michael P. Schön, Karl S. Lang, Volkhard Helms, Meenhard Herlyn, Markus Hoth, Carsten Kummerow and Ivan Bogeski. https://cancerres.aacrjournals.org/content/81/21/5540


Reviews


The multifaceted role of TRAIL signaling in cancer and immunity – Ludmila Cardoso Alves, Nadia Corazza, Olivier Micheau, Philippe Krebs. https://febs.onlinelibrary.wiley.com/doi/full/10.1111/febs.15637

Ferroptosis: machinery and regulation – Xin Chen, Jingbo Li, Rui Kang, Daniel J. Klionsky and Daolin Tang. https://www.tandfonline.com/doi/abs/10.1080/15548627.2020.1810918

Ferroptosis in liver disease: new insights into disease mechanisms – Jing Wu, Yi Wang, Rongtao Jiang, Ran Xue, Xuehong Yin, Muchen Wu and Qinghua Meng. https://www.nature.com/articles/s41420-021-00660-4


Comments


A killer metamorphosis: catching BAK in action at the membrane – Adedolapo M Ojoawo, Tudor Moldoveanu. https://www.embopress.org/doi/abs/10.15252/embj.2021109529

Glutamine gluttony of efferocytes – Alison Jaccard, Xiaoyun Li and Ping-Chih Ho. https://www.nature.com/articles/s42255-021-00462-z

ApoList – September 2021


Bcl-2 family proteins


Lipids modulate the BH3-independent membrane targeting and activation of BAX and Bcl-xL – Victor Vasquez-Montes, Mykola V. Rodnin, Alexander Kyrychenko, and Alexey S. Ladokhin. https://www.pnas.org/content/118/37/e2025834118.abstract?etoc

A combinatorial drug screen in PDX-derived primary rhabdomyosarcoma cells identifies the NOXA – BCL-XL/MCL-1 balance as target for re-sensitization to first-line therapy in recurrent tumors – Gabriele Manzella, Devmini C. Moonamale, Michaela Römmele, Peter Bode, Marco Wachtel, Beat W. Schäfer. https://www.sciencedirect.com/science/article/pii/S1476558621000555#bbib0016


Death receptors, caspases and IAPs


Atrial natriuretic peptide promotes uterine decidualization and a TRAIL-dependent mechanism in spiral artery remodeling – Wei Zhang, Shuo Li, Jinglei Lou, Hui Li, Meng Liu, Ningzheng Dong, Qingyu Wu. https://www.jci.org/articles/view/151053

Development of a protein signature to enable clinical positioning of IAP inhibitors in colorectal cancer – Christopher McCann, Anna Matveeva, Katherine McAllister, Sandra Van Schaeybroeck, Tamas Sessler, Michael Fichtner, Steven Carberry, Markus Rehm, Jochen H.M. Prehn, Daniel B. Longley. https://febs.onlinelibrary.wiley.com/doi/full/10.1111/febs.15801

Non-apoptotic function of caspase-8 confers prostate cancer enzalutamide resistance via NF-κB activation – Jia Xia, Jiahui Zhang, Liangzhe Wang, Hailong Liu, Jie Wang, Junyan Liu, Zhaoqian Liu, Yingjian Zhu, Yingjie Xu, Wen Yang & Yongjiang Yu. https://www.nature.com/articles/s41419-021-04126-4


Necroptosis


Necroptosis activates UPR sensors without disrupting their binding with GRP78 – Wei Liang, Weiwei Qi, Yang Geng, Linhan Wang, Jing Zhao, Kezhou Zhu, Guowei Wu, Zairong Zhang, Heling Pan, Lihui Qian, and Junying Yuan. https://www.pnas.org/content/118/39/e2110476118

E3 ligase TRIM25 ubiquitinates RIP3 to inhibit TNF induced cell necrosis – Pucheng Mei, Feiyan Xie, Jiasong Pan, Sen Wang, Wenqing Gao et al.. https://www.nature.com/articles/s41418-021-00790-3

Gene interfered-ferroptosis therapy for cancers – Jinliang Gao, Tao Luo and Jinke Wang. https://www.nature.com/articles/s41467-021-25632-1


Efferocytosis, entosis etc


Amino acids and mechanistic target of rapamycin regulate the fate of live engulfed cells – Sung Eun Kim, Justin Zhang, Enoch Jiang, Michael Overholtzer. https://faseb.onlinelibrary.wiley.com/doi/10.1096/fj.202100870R

A secreted factor NimrodB4 promotes the elimination of apoptotic corpses by phagocytes in Drosophila – Bianca Petrignani, Samuel Rommelaere, Ketty Hakim-Mishnaevski, Florent Masson, Elodie Ramond, Reut Hilu-Dadia, Mickael Poidevin, Shu Kondo, Estee Kurant, Bruno Lemaitre. https://www.embopress.org/doi/full/10.15252/embr.202052262

Exposure of a specific pleioform of multifunctional glyceraldehyde 3-phosphate dehydrogenase initiates CD14-dependent clearance of apoptotic cells – Surbhi Chaudhary, Anil Patidar, Asmita Dhiman, Gaurav Kumar Chaubey, Rahul Dilawari, Sharmila Talukdar, Radheshyam Modanwal and Manoj Raje. https://www.nature.com/articles/s41419-021-04168-8


Miscellanous


AIM2 forms a complex with pyrin and ZBP1 to drive PANoptosis and host defence – SangJoon Lee, Rajendra Karki, Yaqiu Wang, Lam Nhat Nguyen, Ravi C. Kalathur and Thirumala-Devi Kanneganti. https://www.nature.com/articles/s41586-021-03875-8

UQCRC1 engages cytochrome c for neuronal apoptotic cell death – Yu-Chien Hung, Kuan-Lin Huang, Po-Lin Chen, Jeng-Lin Li, Serena Huei-An Lu, Jui-Chih Chang, Han-Yi Lin, Wen-Chun Lo, Shu-Yi Huang, Tai-Ting Lee, Tai-Yi Lin, Yuzuru Imai, Nobutaka Hattori, Chin-San Liu, Su-Yi Tsai, Chun-Hong Chen, Chin-Hsien Lin, Chih-Chiang Chan. https://www.cell.com/cell-reports/fulltext/S2211-1247(21)01178-5

Genetically encoded cell-death indicators (GEDI) to detect an early irreversible commitment to neurodegeneration – Jeremy W. Linsley, Kevan Shah, Nicholas Castello, Michelle Chan, Dominik Haddad, Zak Doric, Shijie Wang, Wiktoria Leks, Jay Mancini, Viral Oza, Ashkan Javaherian, Ken Nakamura, David Kokel and Steven Finkbeiner. https://www.nature.com/articles/s41467-021-25549-9


Reviews and comments


First we eat, then we do everything else: The dynamic metabolic regulation of efferocytosis – Alissa Trzeciak, Ya-Ting Wang, Justin Shaun Arnold Perry. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(21)00364-8

Mitochondrial regulation of ferroptosis – Boyi Gan. https://rupress.org/jcb/article-abstract/220/9/e202105043/212523/

Targeting ferroptosis in pancreatic cancer: a double-edged sword – Xin Chen, Rui Kang, Guido Kroemer, Daolin Tang. https://www.cell.com/trends/cancer/fulltext/S2405-8033(21)00097-2

Organelle-specific regulation of ferroptosis – Xin Chen, Rui Kang, Guido Kroemer and Daolin Tang. https://www.nature.com/articles/s41418-021-00859-z

Mechanism of interaction between autophagy and apoptosis in cancer – Shreya Das, Nidhi Shukla, Shashi Shekhar Singh, Sapana Kushwaha, Richa Shrivastava. https://link.springer.com/article/10.1007/s10495-021-01687-9

Kinases leave their mark on caspase substrates – Amy M. Weeks. https://portlandpress.com/biochemj/article/478/17/3179/229726