ApoList – July 2020

Bcl-2 family proteins

Homogeneous Oligomers of Pro-apoptotic BAX Reveal Structural Determinants of Mitochondrial Membrane Permeabilization – Zachary J. Hauseman, Edward P. Harvey, Catherine E. Newman, Thomas E. Wales, Joel C. Bucci, Julian Mintseris, Devin K. Schweppe, Liron David, Lixin Fan, Daniel T. Cohen, Henry D. Herce, Rida Mourtada, Yael Ben-Nun, Noah B. Bloch, Scott B. Hansen, Hao Wu, Steven P. Gygi, John R. Engen, Loren D. Walensky. https://www.cell.com/molecular-cell/fulltext/S1097-2765(20)30349-X

Changes in Bcl-2 members in response to ibrutinib or venetoclax uncover functional hierarchy in determining resistance to venetoclax in CLL – Haselager MV, Kielbassa K, Ter Burg J, Bax DJC, Fernandes SM, Borst J, Tam C, Forconi F, Chiodin G, Brown JR, Dubois J, Kater AP, Eldering E. https://doi.org/10.1182/blood.2019004326

Caspase-1 cleaves Bid to release mitochondrial SMAC and drive secondary necrosis in the absence of GSDMD – Rosalie Heilig, Marisa Dilucca, Dave Boucher, Kaiwen W Chen, Dora Hancz, Benjamin Demarco, Kateryna Shkarina and Petr Broz. https://www.life-science-alliance.org/content/3/6/e202000735.abstract

5-Azacitidine Induces NOXA to Prime AML Cells for Venetoclax-Mediated Apoptosis – Sha Jin, Dan Cojocari, Julie J. Purkal, Relja Popovic, Nari N. Talaty, Yu Xiao, Larry R. Solomon, Erwin R. Boghaert, Joel D. Leverson and Darren C. Phillips. https://clincancerres.aacrjournals.org/content/26/13/3371

Spermine synthase and MYC cooperate to maintain colorectal cancer cell survival by repressing Bim expression – Yubin Guo, Qing Ye, Pan Deng, Yanan Cao, Daheng He, Zhaohe Zhou, Chi Wang, Yekaterina Y. Zaytseva, Charles E. Schwartz, Eun Y. Lee, B. Mark Evers, Andrew J. Morris, Side Liu and Qing-Bai She. https://www.nature.com/articles/s41467-020-17067-x

Characterization of an alternative BAK-binding site for BH3 peptides – Kaiqin Ye, Wei X. Meng, Hongbin Sun, Bo Wu, Meng Chen, Yuan-Ping Pang, Jia Gao, Hongzhi Wang, Junfeng Wang, Scott H. Kaufmann and Haiming Dai. https://www.nature.com/articles/s41467-020-17074-y

The chaperone Hsp70 is a BH3 receptor activated by the pro-apoptotic Bim to stabilize anti-apoptotic clients – Zongwei Guo, Ting Song, Ziqian Wang, Donghai Lin, Keke Cao, Peng Liu, Yingang Feng, Xiaodong Zhang, Peiran Wang and Zhichao Zhang. http://www.jbc.org/content/early/2020/07/10/jbc.RA120.013364.abstract

MARCH5 requires MTCH2 to coordinate proteasomal turnover of the MCL1:NOXA complex – Tirta Mario Djajawi, Lei Liu, Jia-nan Gong, Allan Shuai Huang, Ming-jie Luo, Zhen Xu, Toru Okamoto, Melissa J. Call, David C. S. Huang and Mark F. van Delft. https://www.nature.com/articles/s41418-020-0517-0

Death receptors

Engineering bacterial outer membrane vesicles as transdermal nanoplatforms for photo-TRAIL-programmed therapy against melanoma – Li-Hua Peng , Mao-Ze Wang, Yang Chu, Lei Zhang, Jie Niu, Hai-Tao Shao, Tie-Jun Yuan, Zhi-Hong Jiang, Jian-Qing Gao, Xing-Hai Ning. https://advances.sciencemag.org/content/6/27/eaba2735

Convergence of pathway analysis and pattern recognition predicts sensitization to latest generation TRAIL therapeutics by IAP antagonism – Vesna Vetma, Cristiano Guttà, Nathalie Peters, Christian Praetorius, Meike Hutt, Oliver Seifert, Friedegund Meier, Roland Kontermann, Dagmar Kulms and Markus Rehm. https://www.nature.com/articles/s41418-020-0512-5

The pseudo-caspase FLIP(L) regulates cell fate following p53 activation – Andrea Lees, Alexander J. McIntyre, Nyree T. Crawford, Fiammetta Falcone, Christopher McCann, Caitriona Holohan, Gerard P. Quinn, Jamie Z. Roberts, Tamas Sessler, Peter F. Gallagher, Gemma M. A. Gregg, Katherine McAllister, Kirsty M. McLaughlin, Wendy L. Allen, Laurence J. Egan, Aideen E. Ryan, Melissa J. Labonte-Wilson, Philip D. Dunne, Mark Wappett, Vicky M. Coyle, Patrick G. Johnston, Emma M. Kerr, Daniel B. Longley, and Simon S. McDade. https://www.pnas.org/content/117/30/17808.abstract?etoc


Loss of RIPK3 does not impact MYC-driven lymphomagenesis or chemotherapeutic drug-induced killing of malignant lymphoma cells – Rachel Thijssen, Silvia Alvarez-Diaz, Clea Grace, Ming-yuan Gao, David H. Segal, Zhen Xu, Andreas Strasser and David C. S. Huang. https://www.nature.com/articles/s41418-020-0576-2


An Apoptotic Caspase Network Safeguards Cell Death Induction in Pyroptotic MacrophagesNathalia Moraes de Vasconcelos, Nina Van Opdenbosch, Hanne Van Gorp, Rosa Martín-Pérez, Annalisa Zecchin, Peter Vandenabeele, Mohamed Lamkanfi. https://www.cell.com/cell-reports/fulltext/S2211-1247(20)30940-2

Caspase-1 Engages Full-Length Gasdermin D through Two Distinct Interfaces That Mediate Caspase Recruitment and Substrate Cleavage – Zhonghua Liu, Chuanping Wang, Jie Yang, Yinghua Chen, Bowen Zhou, Derek W. Abbott, Tsan Sam Xiao. https://www.cell.com/immunity/fulltext/S1074-7613(20)30237-5

Neutrophil Caspase-11 Is Essential to Defend against a Cytosol-Invasive Bacterium – Stephen B. Kovacs, Changhoon Oh, Vivien I. Maltez, Benjamin D. McGlaughon, Ambika Verma, Edward A. Miao, Youssef Aachoui. https://www.cell.com/cell-reports/fulltext/S2211-1247(20)30948-7

Ferroptosis and miscellaneous necrosis

Smac mimetics can provoke lytic cell death that is neither apoptotic nor necroptotic – Mark A. Miles, Sarah Caruso, Amy A. Baxter, Ivan K. H. Poon, Christine J. Hawkins. https://link.springer.com/article/10.1007/s10495-020-01610-8

Changes in ferrous iron and glutathione promote ferroptosis and frailty in aging Caenorhabditis elegans – Nicole L Jenkins, Simon A James, Agus Salim, Fransisca Sumardy, Terence P Speed, Marcus Conrad, Des R Richardson, Ashley I Bush , Gawain McColl. https://elifesciences.org/articles/56580

Hexokinase 2 displacement from mitochondria‐associated membranes prompts  Ca2+‐dependent death of cancer cellsFrancesco Ciscato, Riccardo Filadi, Ionica Masgras, Marco Pizzi, Oriano Marin, Nunzio Damiano, Paola  Pizzo, Alessandro Gori, Federica Frezzato, Federica Chiara, Livio Trentin, Paolo Bernardi, Andrea  Rasola. https://www.embopress.org/doi/full/10.15252/embr.201949117


Kinetic Heterogeneity of Cancer Cell Fractional Killing – Zintis Inde, Giovanni C. Forcina, Kyle Denton, Scott J. Dixon. https://www.cell.com/cell-reports/fulltext/S2211-1247(20)30826-3

Flow cytometric detection of hyper-polarized mitochondria in regulated and accidental cell death processes – G. Warnes. https://link.springer.com/article/10.1007/s10495-020-01613-5


Double agents of cell death: novel emerging functions of apoptotic regulators – Heather M. Lamb. https://febs.onlinelibrary.wiley.com/doi/full/10.1111/febs.15308

Rational design of genetically encoded reporter genes for optical imaging of apoptosis – Zhijing Xu, Yingzhuang Song, Fu Wang. https://link.springer.com/article/10.1007/s10495-020-01621-5

The mitochondrial permeability transition pore: Is it formed by the ATP synthase, adenine nucleotide translocators or both? – Christopher P. Baines, Manuel Gutiérrez-Aguilar. https://www.sciencedirect.com/science/article/abs/pii/S0005272820300992


Snapshot of a Deadly Embrace: The Caspase-1-GSDMD Interface – Lieselotte Vande Walle, Mohamed Lamkanfi. https://www.cell.com/immunity/fulltext/S1074-7613(20)30274-0

Memoriam – Beth Levine in memoriam. https://www.tandfonline.com/doi/full/10.1080/15548627.2020.1787721

ApoList – June 2020

Bcl-2 family – biology

Endolysosomal Targeting of Mitochondria Is Integral to BAX-Mediated Mitochondrial Permeabilization during Apoptosis SignalingTim Sen Wang, Isabelle Coppens, Anna Saorin, Nathan Ryan Brady, Anne Hamacher-Brady. https://www.cell.com/developmental-cell/fulltext/S1534-5807(20)30403-2

MARCH5 mediates NOXA-dependent MCL1 degradation driven by kinase inhibitors and integrated stress response activationSeiji Arai, Andreas Varkaris, Mannan Nouri, Sen Chen, Lisha Xie, Steven P Balk. https://elifesciences.org/articles/54954

BIF-1 inhibits both mitochondrial and glycolytic ATP production: its downregulation promotes melanoma growthŽiva Frangež, Yuniel Fernández-Marrero, Darko Stojkov, S. Morteza Seyed Jafari, Robert E. Hunger, Valentin Djonov, Carsten Riether and Hans-Uwe Simon. https://www.nature.com/articles/s41388-020-1339-8

Pro-death signaling of cytoprotective heat shock factor 1: upregulation of NOXA leading to apoptosis in heat-sensitive cellsPatryk Janus, Agnieszka Toma-Jonik, Natalia Vydra, Katarzyna Mrowiec, Joanna Korfanty, Marek Chadalski, Piotr Widłak, Karolina Dudek, Anna Paszek, Marek Rusin, Joanna Polańska and Wiesława Widłak. https://www.nature.com/articles/s41418-020-0501-8

Glucocorticoids can induce BIM to trigger apoptosis in the absence of BAX and BAK1Li Dong and David L. Vaux. https://www.nature.com/articles/s41419-020-2599-5

The pro-survival Bcl-2 family member A1 delays spontaneous and FAS ligand-induced apoptosis of activated neutrophilsRobyn L. Schenk, Lahiru Gangoda, Kate E. Lawlor, Lorraine A. O’Reilly, Andreas Strasser and Marco J. Herold. https://www.nature.com/articles/s41419-020-2676-9

Defective nucleotide-dependent assembly and membrane fusion in Mfn2 CMT2A variants improved by BaxNyssa B Samanas, Emily A Engelhart and Suzanne Hoppins. https://www.life-science-alliance.org/content/3/5/e201900527.abstract

BH3 proteins and cancer

Failed Apoptosis Enhances Melanoma Cancer Cell AggressivenessKevin Berthenet, Camila Castillo Ferrer, Deborah Fanfone, Nikolay Popgeorgiev, David Neves, Philippe Bertolino, Benjamin Gibert, Hector Hernandez-Vargas, Gabriel Ichim. https://www.cell.com/cell-reports/fulltext/S2211-1247(20)30711-7

High-throughput dynamic BH3 profiling may quickly and accurately predict effective therapies in solid tumorsPatrick D. Bhola , Eman Ahmed, Jennifer L. Guerriero, Ewa Sicinska, Emily Su, Elizaveta Lavrova, Jing Ni, Otari Chipashvili, Timothy Hagan, Marissa S. Pioso, Kelley McQueeney, Kimmie Ng, Andrew J. Aguirre, James M. Cleary, David Cocozziello, Alaba Sotayo, Jeremy Ryan, Jean J. Zhao, Anthony Letai. https://stke.sciencemag.org/content/13/636/eaay1451

MCL1 inhibitors S63845/MIK665 plus Navitoclax synergistically kill difficult-to-treat melanoma cellsNabanita Mukherjee, Jenette Skees, Kaleb J. Todd, Drake A. West, Karoline A. Lambert, William A. Robinson, Carol M. Amato, Kasey L. Couts, Robert Van Gulick, Morgan MacBeth, Kelsey Nassar, Aik-Choon Tan, Zili Zhai, Mayumi Fujita, Stacey M. Bagby, Chiara R. Dart, James R. Lambert, David A. Norris and Yiqun G. Shellman. https://www.nature.com/articles/s41419-020-2646-2

BIK drives an aggressive breast cancer phenotype through sublethal apoptosis and predicts poor prognosis of ER-positive breast cancerVrajesh Pandya, John Maringa Githaka, Namrata Patel, Richard Veldhoen, Judith Hugh, Sambasivarao Damaraju, Todd McMullen, John Mackey and Ing Swie Goping. https://www.nature.com/articles/s41419-020-2654-2

Deep profiling of apoptotic pathways with mass cytometry identifies a synergistic drug combination for killing myeloma cellsCharis E. Teh, Jia-Nan Gong, David Segal, Tania Tan, Cassandra J. Vandenberg et al. https://www.nature.com/articles/s41418-020-0498-z


Caspase-8-Dependent Inflammatory Responses Are Controlled by Its Adaptor, FADD, and NecroptosisBart Tummers, Luigi Mari, Clifford S. Guy, Bradlee L. Heckmann, Diego A. Rodriguez, Sebastian Rühl, Julien Moretti, Jeremy Chase Crawford, Patrick Fitzgerald, Thirumala-Devi Kanneganti, Laura J. Janke, Stephane Pelletier, J. Magarian Blander, Douglas R. Green. https://www.cell.com/immunity/fulltext/S1074-7613(20)30168-0

FADD and Caspase-8 Regulate Gut Homeostasis and Inflammation by Controlling MLKL- and GSDMD-Mediated Death of Intestinal Epithelial CellsRobin Schwarzer, Huipeng Jiao, Laurens Wachsmuth, Achim Tresch, Manolis Pasparakis. https://www.cell.com/immunity/fulltext/S1074-7613(20)30160-6

Dissecting DISC regulation via pharmacological targeting of caspase-8/c-FLIPL heterodimerLaura K. Hillert, Nikita V. Ivanisenko, Denise Busse, Johannes Espe, Corinna König, Sergey E. Peltek, Nikolai A. Kolchanov, Vladimir A. Ivanisenko and Inna N. Lavrik. https://www.nature.com/articles/s41418-020-0489-0

Cytomegalovirus inhibition of extrinsic apoptosis determines fitness and resistance to cytotoxic CD8 T cellsM. Zeeshan Chaudhry, Rosaely Casalegno-Garduno, Katarzyna M. Sitnik, Bahram Kasmapour, Ann-Kathrin Pulm, Ilija Brizic, Britta Eiz-Vesper, Andreas Moosmann, Stipan Jonjic, Edward S. Mocarski, and Luka Cicin-Sain. https://www.pnas.org/content/117/23/12961.abstract?etoc

Caspases and IAPs

Noncanonical inhibition of caspase-3 by a nuclear microRNA confers endothelial protection by autophagy in atherosclerosisDonato Santovito , Virginia Egea, Kiril Bidzhekov, Lucia Natarelli, André Mourão, Xavier Blanchet, Kanin Wichapong, Maria Aslani, Coy Brunßen, Michael Horckmans, Michael Hristov, Arie Geerlof, Esther Lutgens, Mat J.A.P. Daemen, Tilman Hackeng, Christian Ries, Triantafyllos Chavakis, Henning Morawietz, Ronald Naumann, Philipp von Hundelshausen, Sabine Steffens, Johan Duchêne, Remco T.A. Megens, Michael Sattler, Christian Weber. https://stm.sciencemag.org/content/12/546/eaaz2294

The Lumiptosome, an engineered luminescent form of the apoptosome can report cell death by using the same Apaf-1 dependent pathwayElaheh Sadat Hosseini, Maryam Nikkhah, Amir Ali Hamidieh, Howard O. Fearnhead, Jean-Paul Concordet and Saman Hosseinkhani. http://jcs.biologists.org/content/133/10/jcs242636?etoc

A small-molecule ARTS mimetic promotes apoptosis through degradation of both XIAP and Bcl-2Dana Mamriev, Ruqaia Abbas, Franca-Maria Klingler, Juliana Kagan, Nir Kfir, Alastair Donald, Keren Weidenfeld, David W. Sheppard, Dalit Barkan and Sarit Larisch. https://www.nature.com/articles/s41419-020-2670-2

XAF1 as a modifier of p53 function and cancer susceptibilityEmilia M. Pinto , Bonald C. Figueiredo, Wenan Chen […] Gang Wu, Gerard P. Zambetti. https://advances.sciencemag.org/content/6/26/eaba3231

Necroptosis and RIP kinases

MLKL trafficking and accumulation at the plasma membrane control the kinetics and threshold for necroptosisAndre L. Samson, Ying Zhang, Niall D. Geoghegan, Xavier J. Gavin, Katherine A. Davies, Michael J. Mlodzianoski, Lachlan W. Whitehead, Daniel Frank, Sarah E. Garnish, Cheree Fitzgibbon, Anne Hempel, Samuel N. Young, Annette V. Jacobsen, Wayne Cawthorne, Emma J. Petrie, Maree C. Faux, Kristy Shield-Artin, Najoua Lalaoui, Joanne M. Hildebrand, John Silke, Kelly L. Rogers, Guillaume Lessene, Edwin D. Hawkins and James M. Murphy. https://www.nature.com/articles/s41467-020-16887-1

Distinct pseudokinase domain conformations underlie divergent activation mechanisms among vertebrate MLKL orthologuesKatherine A. Davies, Cheree Fitzgibbon, Samuel N. Young, Sarah E. Garnish, Wayland Yeung, Diane Coursier, Richard W. Birkinshaw, Jarrod J. Sandow, Wil I. L. Lehmann, Lung-Yu Liang, Isabelle S. Lucet, James D. Chalmers, Wayne M. Patrick, Natarajan Kannan, Emma J. Petrie, Peter E. Czabotar and James M. Murphy. https://www.nature.com/articles/s41467-020-16823-3

RIPK3 upregulation confers robust proliferation and collateral cystine-dependence on breast cancer recurrenceChao-Chieh Lin, Nathaniel W. Mabe, Yi-Tzu Lin, Wen-Hsuan Yang, Xiaohu Tang, Lisa Hong, Tianai Sun, Jeremy Force, Jeffrey R. Marks, Tso-Pang Yao, James V. Alvarez and Jen-Tsan Chi. https://www.nature.com/articles/s41418-020-0499-y

Hepatocyte-specific TAK1 deficiency drives RIPK1 kinase-dependent inflammation to promote liver fibrosis and hepatocellular carcinomaShuixia Tan, Jing Zhao, Ziyu Sun, Shuangyi Cao, Kongyan Niu, Yedan Zhong, Han Wang, Linyu Shi, Heling Pan, Junhao Hu, Lihui Qian, Nan Liu, and Junying Yuan. https://www.pnas.org/content/117/25/14231.abstract?etoc


FDA-approved disulfiram inhibits pyroptosis by blocking gasdermin D pore formationJun Jacob Hu, Xing Liu, Shiyu Xia, Zhibin Zhang, Ying Zhang, Jingxia Zhao, Jianbin Ruan, Xuemei Luo, Xiwen Lou, Yang Bai, Junhong Wang, L. Robert Hollingsworth, Venkat Giri Magupalli, Li Zhao, Hongbo R. Luo, Justin Kim, Judy Lieberman and Hao Wu. https://www.nature.com/articles/s41590-020-0669-6

Induction of ASC pyroptosis requires gasdermin D or caspase-1/11-dependent mediators and IFNβ from pyroptotic macrophagesCuiping Zhang, Caiqi Zhao, Xiaoyan Chen, Rujia Tao, Sijiao Wang, Guangxun Meng, Xing Liu, Changzhou Shao and Xiao Su. https://www.nature.com/articles/s41419-020-2664-0

Extended subsite profiling of the pyroptosis effector protein gasdermin D reveals a region recognized by inflammatory caspase-11Betsaida Bibo-Verdugo, Scott J Snipas, Sonia Kolt, Marcin Poreba and Guy S Salvesen. http://www.jbc.org/content/early/2020/06/18/jbc.RA120.014259.abstract


Senescence, Necrosis, and Apoptosis Govern Circulating Cell-free DNA Release KineticsAriana Rostami, Meghan Lambie, Caberry W. Yu, Vuk Stambolic, John N. Waldron, Scott V. Bratman. https://www.cell.com/cell-reports/fulltext/S2211-1247(20)30811-1

The anti-cancer drug ABTL0812 induces ER stress-mediated cytotoxic autophagy by increasing dihydroceramide levels in cancer cellsPau Muñoz-Guardiola, Josefina Casas, Elisabet Megías-Roda, Sònia Solé, Héctor Perez-Montoyo, Marc Yeste-Velasco, Tatiana Erazo, Nora Diéguez-Martínez, Sergio Espinosa-Gil, Cristina Muñoz-Pinedo, Guillermo Yoldi, Jose L Abad, Miguel F Segura, Teresa Mora, Margarita Romeo, Joaquim Bosch-Barrera, Ana Oaknin, Jose Alfón, Carles Domènech, Gemma Fabriàs, Guillermo Velasco and Jose M Lizcano. https://www.tandfonline.com/doi/full/10.1080/15548627.2020.1761651

Hexokinase II dissociation alone cannot account for changes in heart mitochondrial function, morphology and sensitivity to permeability transition pore opening following ischemiaGonçalo C Pereira, Laura Lee, Nadiia Rawlings, Joke Ouwendijk, Joanne E Parker, Tatyana N Andrienko, Jeremy M Henley, Andrew P Halestrap. https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0234653


The clearance of dead cells by efferocytosisEmilio Boada-Romero, Jennifer Martinez, Bradlee L. Heckmann and Douglas R. Green. https://www.nature.com/articles/s41580-020-0232-1

Cell Death in the Origin and Treatment of CancerAndreas Strasser, David L. Vaux. https://www.cell.com/molecular-cell/fulltext/S1097-2765(20)30315-4

Noncanonical Cell Fate Regulation by Bcl-2 ProteinsStephen Jun Fei Chong, Saverio Marchi, Giulia Petroni, Guido Kroemer, Lorenzo Galluzzi, Shazib Pervaiz. https://www.cell.com/trends/cell-biology/fulltext/S0962-8924(20)30070-2

Photodynamic therapy: autophagy and mitophagy, apoptosis and paraptosisDavid Kessel and John J. Reiners. https://www.tandfonline.com/doi/abs/10.1080/15548627.2020.1783823

Uncovering the PIDDosome and caspase-2 as regulators of organogenesis and cellular differentiationValentina C. Sladky and Andreas Villunger. https://www.nature.com/articles/s41418-020-0556-6

Comments / other

Caspase-8 and FADD: Where Cell Death and Inflammation CollideMarcelo Pires Amaral, Karina Ramalho Bortoluci. https://www.cell.com/immunity/fulltext/S1074-7613(20)30216-8

Deadly Encounter: Endosomes Meet Mitochondria to Initiate ApoptosisMariella Vicinanza, David C. Rubinsztein. https://www.cell.com/developmental-cell/fulltext/S1534-5807(20)30419-6

Pyroptosis Takes Aim at NeurodevelopmentJaeda C. Coutinho-Budd, Heather T. Broihier. https://www.cell.com/developmental-cell/fulltext/S1534-5807(20)30402-0

Regulating RIPK1: another way in which ULK1 contributes to survivalWenxian Wu and Björn Stork. https://www.tandfonline.com/doi/full/10.1080/15548627.2020.1783110

MLKL contributes to Western diet-induced liver injury through inhibiting autophagyXiaoqin Wu and Laura E. Nagy. https://www.tandfonline.com/doi/abs/10.1080/15548627.2020.1760624

Cell death through the ages: The ICDS 25th Anniversary MeetingJarvier N. Mohammed, Jesse D. Gelles, Camila RubioPatiño, Madhavika N. Serasinghe, Andrew P. Trotta, Richard A. Lockshin, Zahra Zakeri, Jerry E. Chipuk. https://febs.onlinelibrary.wiley.com/doi/abs/10.1111/febs.15252

ApoList – May 2020

Bcl-2 family proteins

Identification of a Covalent Molecular Inhibitor of Anti-apoptotic BFL-1 by Disulfide Tethering – Edward P. Harvey, Zachary J. Hauseman, Daniel T. Cohen, T. Justin Rettenmaier, Susan Lee, Annissa J. Huhn, Thomas E. Wales, Hyuk-Soo Seo, James Luccarelli, Catherine E. Newman, Rachel M. Guerra, Gregory H. Bird, Sirano Dhe-Paganon, John R. Engen, James A. Wells, Loren D. Walensky. https://www.cell.com/cell-chemical-biology/fulltext/S2451-9456(20)30118-5?sf233998513=1

BCL-2 antagonism sensitizes cytotoxic T cell–resistant HIV reservoirs to elimination ex vivo – Yanqin Ren, Szu Han Huang, Shabnum Patel, Winiffer D. Conce Alberto, Dean Magat, Dughan Ahimovic, Amanda B. Macedo, Ryan Durga, Dora Chan, Elizabeth Zale, Talia M. Mota, Ronald Truong, Thomas Rohwetter, Chase D. McCann, Colin M. Kovacs, Erika Benko, Avery Wimpelberg, Christopher Cannon, W. David Hardy, Alberto Bosque, Catherine M. Bollard, and R. Brad Jones. https://www.jci.org/articles/view/132374

Death receptors

Quantitative single‐molecule imaging of TNFR1 reveals zafirlukast as antagonist of TNFR1 clustering and TNFα‐induced NF‐ĸB signaling – Nadine Weinelt, Christos Karathanasis, Sonja Smith, Juliane Medler, Sebastian Malkusch, Simone Fulda, Harald Wajant, Mike Heilemann, Sjoerd J. L. van Wijk. https://jlb.onlinelibrary.wiley.com/doi/10.1002/JLB.2AB0420-572RR#.XrvxctJyfu8.twitter

Doxorubicin sensitizes cancer cells to Smac mimetic via synergistic activation of the CYLD/RIPK1/FADD/caspase-8-dependent apoptosis – Chengkui Yang, Qiao Ran, Yifei Zhou, Shan Liu, Cong Zhao, Xiaoliang Yu, Fang Zhu, Yuting Ji, Qian Du, Tao Yang, Wei Zhang and Sudan He. https://link.springer.com/article/10.1007/s10495-020-01604-6


Non-Canonical Caspase Activity Antagonizes p38 MAPK Stress-Priming Function to Support Development – Benjamin P. Weaver, Yi M. Weaver, Shizue Omi, Wang Yuan, Jonathan J. Ewbank, Min Han. https://www.cell.com/developmental-cell/fulltext/S1534-5807(20)30224-0

Leishmania aethiopica cell‐to‐cell spreading involves caspase‐3, AkT, and NF‐κB but not PKC‐δ activation and involves uptake of LAMP‐1‐positive bodies containing parasites – Medhavi Ranatunga, Rajeev Rai, Simon C. W. Richardson, Paul Dyer, Laurence Harbige, Andrew Deacon, Lauren Pecorino, Giulia T. M. Getti. https://febs.onlinelibrary.wiley.com/doi/abs/10.1111/febs.15166

Involvement of CASP9 (caspase 9) in IGF2R/CI-MPR endosomal transport – Jie Han, Leslie A. Goldstein, Wen Hou, Simon C. Watkins and Hannah Rabinowich. https://www.tandfonline.com/doi/abs/10.1080/15548627.2020.1761742


The death-inducing activity of RIPK1 is regulated by the pH environment – Kenta Moriwaki , Sakthi Balaji, Francis Ka-Ming Chan. https://stke.sciencemag.org/content/13/631/eaay7066

Crucial Roles of the RIP Homotypic Interaction Motifs of RIPK3 in RIPK1-Dependent Cell Death and Lymphoproliferative Disease – Haiwei Zhang, Xiaoxia Wu, Xiaoming Li, Ming Li, Fang Li, Lingxia Wang, Xixi Zhang, Yue Zhang, Yan Luo, Hui Wang, Yiguo Jiang, Haibing Zhang. https://www.cell.com/cell-reports/fulltext/S2211-1247(20)30603-3

The Zα2 domain of ZBP1 is a molecular switch regulating influenza-induced PANoptosis and perinatal lethality during development – Sannula Kesavardhana, R. K. Subbarao Malireddi, Amanda R Burton, Shaina N Porter, Peter Vogel, Shondra M Pruett-Miller and Thirumala-Devi Kanneganti. http://www.jbc.org/content/early/2020/04/29/jbc.RA120.013752.abstract

Attenuated Epigenetic Suppression of Muscle Stem Cell Necroptosis Is Required for Efficient Regeneration of Dystrophic Muscles – Krishnamoorthy Sreenivasan, Alessandro Ianni, Carsten Künne, Boris Strilic, Stefan Günther, Eusebio Perdiguero, Marcus Krüger, Simone Spuler, Stefan Offermanns, Pablo Gómez-del Arco, Juan Miguel Redondo, Pura Munoz-Canoves, Johnny Kim, Thomas Braun. https://www.cell.com/cell-reports/fulltext/S2211-1247(20)30605-7


Granzyme A from cytotoxic lymphocytes cleaves GSDMB to trigger pyroptosis in target cells – Zhiwei Zhou, Huabin He, Kun Wang, Xuyan Shi, Yupeng Wang, Ya Su, Yao Wang, Da Li, Wang Liu, Yongliang Zhang, Lianjun Shen, Weidong Han, Lin Shen, Jingjin Ding, Feng Shao. https://science.sciencemag.org/content/368/6494/943?utm


Zika virus noncoding RNA suppresses apoptosis and is required for virus transmission by mosquitoes – Andrii Slonchak, Leon E. Hugo, Morgan E. Freney, Sonja Hall-Mendelin, Alberto A. Amarilla, Francisco J. Torres, Yin Xiang Setoh, Nias Y. G. Peng, Julian D. J. Sng, Roy A. Hall, Andrew F. van den Hurk, Gregor J. Devine and Alexander A. Khromykh. https://www.nature.com/articles/s41467-020-16086-y

CXCR1 and CXCR2 Chemokine Receptor Agonists Produced by Tumors Induce Neutrophil Extracellular Traps that Interfere with Immune CytotoxicityÁlvaro Teijeira, Saray Garasa, María Gato, Carlos Alfaro, Itziar Migueliz, Assunta Cirella, Carlos de Andrea, Maria Carmen Ochoa, Itziar Otano, Iñaki Etxeberria, Maria Pilar Andueza, Celia P. Nieto, Leyre Resano, Arantza Azpilikueta, Marcello Allegretti, Maria de Pizzol, Mariano Ponz-Sarvisé, Ana Rouzaut, Miguel F. Sanmamed, Kurt Schalper, Michael Carleton, Mario Mellado, María E. Rodriguez-Ruiz, Pedro Berraondo, Jose L. Perez-Gracia, Ignacio Melero. https://www.cell.com/immunity/fulltext/S1074-7613(20)30089-3


BCL-2 family deregulation in colorectal cancer: potential for BH3 mimetics in therapy – Prashanthi Ramesh and Jan Paul Medema. https://link.springer.com/article/10.1007/s10495-020-01601-9

Emerging Mechanisms and Disease Relevance of Ferroptosis – Brent R. Stockwell, Xuejun Jiang, Wei Gu. https://www.cell.com/trends/cell-biology/fulltext/S0962-8924(20)30054-4

BAX inhibitor‐1: between stress and survival – Cynthia Lebeaupin, Marina Blanc, Déborah Vallée, Harald Keller, Béatrice Bailly‐Maitre. https://febs.onlinelibrary.wiley.com/doi/abs/10.1111/febs.15179

The emerging role of paraptosis in tumor cell biology: Perspectives for cancer prevention and therapy with natural compoundsFabrizio Fontana, Michela Raimondi, Monica Marzagalli, Alessandro Di Domizio, Patrizia Limonta. https://www.sciencedirect.com/science/article/abs/pii/S0304419X19301945

Caspase-8: The double-edged sword – Ranadip Mandal, Joan Compte Barrón, Izabela Kostova, Sven Becker, Klaus Strebhardt. https://www.sciencedirect.com/science/article/abs/pii/S0304419X19301763

New insights into the regulation of apoptosis, necroptosis, and pyroptosis by receptor interacting protein kinase 1 and caspase-8Robin Schwarzer, Lucie Laurien, Manolis Pasparakis. https://www.sciencedirect.com/science/article/abs/pii/S0955067420300272?dgcid=raven_sd_via_email

The Role of Caspase-2 in Regulating Cell Fate – Vasanthy Vigneswara and Zubair Ahmed. https://www.mdpi.com/2073-4409/9/5/1259

Inhibition of Anti-Apoptotic Bcl-2 Proteins in Preclinical and Clinical Studies: Current Overview in CancerSimona D’Aguanno and Donatella Del Bufalo. https://www.mdpi.com/2073-4409/9/5/1287

Tumour Cell Secretome in Chemoresistance and Tumour Recurrence – Emma C. Madden, Adrienne M. Gorman, Susan E. Logue, Afshin Samali. https://www.cell.com/trends/cancer/fulltext/S2405-8033(20)30081-9

Novel Forms of Immunomodulation for Cancer TherapyAlfonso Serrano-del Valle, Javier Naval, Alberto Anel, Isabel Marzo. https://www.cell.com/trends/cancer/fulltext/S2405-8033(20)30076-5

Cysteine Depletion, a Key Action to Challenge Cancer Cells to Ferroptotic Cell Death – Daher B, Vučetić M, Pouysségur J. https://www.frontiersin.org/articles/10.3389/fonc.2020.00723/full

SnapShot: Ferroptosis – Kamyar Hadian, Brent R. Stockwell. https://www.cell.com/cell/fulltext/S0092-8674(20)30504-3


Development or Disease: Caspases Balance Growth and Immunity in C. elegans – Olya Yarychkivska, Shai Shaham. https://www.cell.com/developmental-cell/fulltext/S1534-5807(20)30273-2

Killer cells add fire to fuel immunotherapy – Christopher J. Nicolai, David H. Raulet. https://science.sciencemag.org/content/368/6494/943

ApoList – April 2020

Bcl-2 family proteins

Separase-triggered apoptosis enforces minimal length of mitosis – Susanne Hellmuth, Olaf Stemmann. https://www.nature.com/articles/s41586-020-2187-y

The apoptosis inhibitor Bcl-xL controls breast cancer cell migration through mitochondria-dependent reactive oxygen species production – Margaux Bessou, Jonathan Lopez, Rudy Gadet, Mathieu Deygas, Nikolay Popgeorgiev, Delphine Poncet, Adrien Nougarède, Pauline Billard, Ivan Mikaelian, Philippe Gonzalo, Ruth Rimokh and Germain Gillet. https://www.nature.com/articles/s41388-020-1212-9

Melanoma-specific bcl-2 promotes a protumoral M2-like phenotype by tumor-associated macrophagesMarta Di Martile, Valentina Farini, Francesca Maria Consonni, Daniela Trisciuoglio, Marianna Desideri, Elisabetta Valentini, Simona D’Aguanno, Maria Grazia Tupone, Simonetta Buglioni, Cristiana Ercolani, Enzo Gallo, Bruno Amadio, Irene Terrenato, Maria Laura Foddai, Antonio Sica and Donatella Del Bufalo. https://jitc.bmj.com/content/8/1/e000489

Loss of BIM in T cells results in BCL-2 family BH3-member compensation but incomplete cell death sensitivity normalization – Lindsey M. Ludwig, Lauren E. Roach, Samuel G. Katz and James L. LaBelle. https://link.springer.com/article/10.1007/s10495-020-01593-6

Inhibition of BCL2 Family Members Increases the Efficacy of Copper Chelation in BRAFV600E-Driven Melanoma – Ye-Jin Kim, Tiffany Tsang, Grace R. Anderson, Jessica M. Posimo and Donita C. Brady. https://cancerres.aacrjournals.org/content/80/7/1387

Monocytic Subclones Confer Resistance to Venetoclax-Based Therapy in Patients with Acute Myeloid Leukemia – Shanshan Pei, Daniel A. Pollyea, Annika Gustafson, Brett M. Stevens, Mohammad Minhajuddin, Rui Fu, Kent A. Riemondy, Austin E. Gillen, Ryan M. Sheridan, Jihye Kim, James C. Costello, Maria L. Amaya, Anagha Inguva, Amanda Winters, Haobin Ye, Anna Krug, Courtney L. Jones, Biniam Adane, Nabilah Khan, Jessica Ponder, Jeffrey Schowinsky, Diana Abbott, Andrew Hammes, Jason R. Myers, John M. Ashton, Travis Nemkov, Angelo D’Alessandro, Jonathan A. Gutman, Haley E. Ramsey, Michael R. Savona, Clayton A. Smith and Craig T. Jordan. https://cancerdiscovery.aacrjournals.org/content/10/4/536

The senotherapeutic drug ABT-737 disrupts aberrant p21 expression to restore liver regeneration in adult mice – Birgit Ritschka, Tania Knauer-Meyer, Daniel Sampaio Gonçalves, Alba Mas, Jean-Luc Plassat, Matej Durik, Hugues Jacobs, Elisa Pedone, Umberto Di Vicino, Maria Pia Cosma and William M. Keyes. http://genesdev.cshlp.org/content/34/7-8/489.abstract?etoc

Death receptors

Impaired Death Receptor Signaling in Leukemia Causes Antigen-Independent Resistance by Inducing CAR T-cell Dysfunction – Nathan Singh, Yong Gu Lee, Olga Shestova, Pranali Ravikumar, Katharina E. Hayer, Seok Jae Hong, Xueqing Maggie Lu, Raymone Pajarillo, Sangya Agarwal, Shunichiro Kuramitsu, Elena J. Orlando, Karen Thudium Mueller, Charly R. Good, Shelley L. Berger, Ophir Shalem, Matthew D. Weitzman, Noelle V. Frey, Shannon L. Maude, Stephan A. Grupp, Carl H. June, Saar Gill and Marco Ruella. https://cancerdiscovery.aacrjournals.org/content/10/4/552

Blocking the death checkpoint protein TRAIL improves cardiac function after myocardial infarction in monkeys, pigs, and rats – Yaohui Wang , Hailong Zhang, Zhizeng Wang, Yinxiang Wei, Mingli Wang, Meichen Liu, Xuance Wang, Yinan Jiang, Gongning Shi, Dongmei Zhao, Zhengyan Yang, Zhiguang Ren, Jing Li, Zhenkai Zhang, Zhenfeng Wang, Bei Zhang, Beibei Zong, Xueke Lou, Chengguo Liu, Zihui Wang, Hao Zhang, Ningya Tao, Xuefang Li, Xingkun Zhang, Yafei Guo, Yang Ye, Yu Qi, Hui Li, Man Wang, Rongxin Guo, Guanchang Cheng, Shulian Li, Jun Zhang, Guangchao Liu, Lihui Chai, Qiang Lou, Xia Li, Xiukun Cui, Erhe Gao, Zheng Dong, Yanzhong Hu, Youhai H. Chen, Yuanfang Ma. https://stm.sciencemag.org/content/12/540/eaaw3172

A Two-Cell Model for IL-1β Release Mediated by Death-Receptor Signaling – Carlos A. Donado, Anh B. Cao, Daimon P. Simmons, Ben A. Croker, Patrick J. Brennan, Michael B. Brenner. https://www.cell.com/cell-reports/fulltext/S2211-1247(20)30344-2

Dynamic Fas signaling network regulates neural stem cell proliferation and memory enhancement – Seokhwi Kim , Nury Kim, Jinsu Lee, Sungsoo Kim, Jongryul Hong, Seungkyu Son, Won Do Heo. https://advances.sciencemag.org/content/6/17/eaaz9691

Necroptosis and RIP kinases

Identification of MLKL membrane translocation as a checkpoint in necroptotic cell death using Monobodies – Emma J. Petrie, Richard W. Birkinshaw, Akiko Koide, Eric Denbaum, Joanne M. Hildebrand, Sarah E. Garnish, Katherine A. Davies, Jarrod J. Sandow, Andre L. Samson, Xavier Gavin, Cheree Fitzgibbon, Samuel N. Young, Patrick J. Hennessy, Phoebe P. C. Smith, Andrew I. Webb, Peter E. Czabotar, Shohei Koide, and James M. Murphy. https://www.pnas.org/content/117/15/8468.abstract?etoc

The Autophagy-Initiating Kinase ULK1 Controls RIPK1-Mediated Cell Death – Wenxian Wu, Xiaojing Wang, Niklas Berleth, Jana Deitersen, Nora Wallot-Hieke, Philip Böhler, David Schlütermann, Fabian Stuhldreier, Jan Cox, Katharina Schmitz, Sabine Seggewiß, Christoph Peter, Gary Kasof, Anja Stefanski, Kai Stühler, Astrid Tschapek, Axel Gödecke, Björn Stork. https://www.cell.com/cell-reports/fulltext/S2211-1247(20)30457-5

Autophosphorylation at serine 166 regulates RIP kinase 1-mediated cell death and inflammation – Lucie Laurien, Masahiro Nagata, Hannah Schünke, Tom Delanghe, Janica L. Wiederstein, Snehlata Kumari, Robin Schwarzer, Teresa Corona, Marcus Krüger, Mathieu J. M. Bertrand, Vangelis Kondylis and Manolis Pasparakis. https://www.nature.com/articles/s41467-020-15466-8

Caspases / Pyroptosis

Caspase-6 Is a Key Regulator of Innate Immunity, Inflammasome Activation, and Host Defense – Min Zheng, Rajendra Karki, Peter Vogel, Thirumala-Devi Kanneganti. https://www.cell.com/cell/fulltext/S0092-8674(20)30333-0

A Two-Cell Model for IL-1β Release Mediated by Death-Receptor Signaling – Carlos A. Donado, Anh B. Cao, Daimon P. Simmons, Ben A. Croker, Patrick J. Brennan, Michael B. Brenner. https://www.cell.com/cell-reports/fulltext/S2211-1247(20)30344-2


Cysteine depletion induces pancreatic tumor ferroptosis in mice – Michael A. Badgley, Daniel M. Kremer, H. Carlo Maurer, Kathleen E. DelGiorno, Ho-Joon Lee, Vinee Purohit, Irina R. Sagalovskiy, Alice Ma, Jonathan Kapilian, Christina E. M. Firl, Amanda R. Decker, Steve A. Sastra, Carmine F. Palermo, Leonardo R. Andrade, Peter Sajjakulnukit, Li Zhang, Zachary P. Tolstyka, Tal Hirschhorn, Candice Lamb, Tong Liu, Wei Gu, E. Scott Seeley, Everett Stone, George Georgiou, Uri Manor, Alina Iuga, Geoffrey M. Wahl, Brent R. Stockwell, Costas A. Lyssiotis, Kenneth P. Olive. https://science.sciencemag.org/content/368/6486/85

MDM2 and MDMX promote ferroptosis by PPARα-mediated lipid remodeling – Divya Venkatesh, Nicholas A. O’Brien, Fereshteh Zandkarimi, David R. Tong, Michael E. Stokes, Denise E. Dunn, Everett S. Kengmana, Allegra T. Aron, Alyssa M. Klein, Joleen M. Csuka, Sung-Hwan Moon, Marcus Conrad, Christopher J. Chang, Donald C. Lo, Angelo D’Alessandro, Carol Prives and Brent R. Stockwell. http://genesdev.cshlp.org/content/34/7-8/526.abstract?etoc


Cell death induced by cytotoxic CD8+ T cells is immunogenic and primes caspase-3–dependent spread immunity against endogenous tumor antigensPaula Jaime-Sanchez, Iratxe Uranga-Murillo, Nacho Aguilo, Sofia C Khouili, Maykel A Arias, David Sancho, Julian Pardo. https://jitc.bmj.com/content/8/1/e000528

Cellular cytotoxicity is a form of immunogenic cell deathLuna Minute, Alvaro Teijeira, Alfonso R Sanchez-Paulete, Maria C Ochoa, Maite Alvarez, Itziar Otano, Iñaki Etxeberrria, Elixabet Bolaños, Arantza Azpilikueta, Saray Garasa, Noelia Casares, Jose Luis Perez Gracia, Maria E Rodriguez-Ruiz, Pedro Berraondo and Ignacio Melero. https://jitc.bmj.com/content/8/1/e000325

A nonpeptidyl molecule modulates apoptosis-like cell death by inhibiting P. falciparum metacapase-2 – Vandana, Sudha Shankar, Kona Madhavinadha Prasad, Mohammad Kashif, Inderjeet Kalia, Rajkishor Rai, Agam P. Singh, Kailash C. Pandey. https://portlandpress.com/biochemj/article-abstract/477/7/1323/222446/

Starvation and antimetabolic therapy promote cytokine release and recruitment of immune cells – Franziska Püschel, Francesca Favaro, Jaime Redondo-Pedraza, Estefanía Lucendo, Raffaella Iurlaro, Sandrine Marchetti, Blanca Majem, Eric Eldering, Ernest Nadal, Jean-Ehrland Ricci, Eric Chevet, and Cristina Muñoz-Pinedo. https://www.pnas.org/content/early/2020/04/17/1913707117/


Controlling Cell Death through Post-translational Modifications of DED Proteins – Kamil Seyrek, Nikita V. Ivanisenko, Max Richter, Laura K. Hillert, Corinna König, Inna N. Lavrik. https://www.cell.com/trends/cell-biology/fulltext/S0962-8924(20)30041-6

An unexpected turn of fortune: targeting TRAIL-Rs in KRAS-driven cancer – Silvia von Karstedt and Henning Walczak. https://www.nature.com/articles/s41420-020-0249-4

Stress Management: Death Receptor Signalling and Cross-Talks with the Unfolded Protein Response in Cancer – Elodie Lafont. https://www.mdpi.com/2072-6694/12/5/1113

Cell-Free DNA and Apoptosis: How Dead Cells Inform About the Living – Ellen Heitzer, Lisa Auinger, Michael R. Speicher. https://www.cell.com/trends/molecular-medicine/fulltext/S1471-4914(20)30040-X

Consensus guidelines for the definition, detection and interpretation of immunogenic cell death – Lorenzo Galluzzi, Ilio Vitale, Sarah Warren, Sandy Adjemian, Patrizia Agostinis, Aitziber Buqué Martinez, Timothy A Chan, George Coukos, Sandra Demaria, Eric Deutsch, Dobrin Draganov, Richard L Edelson, Silvia C Formenti, Jitka Fucikova, Lucia Gabriele, Udo S Gaipl, Sofia R Gameiro, Abhishek D Garg, Encouse Golden, Jian Han, Kevin J Harrington, Akseli Hemminki, James W Hodge, Dewan Md Sakib Hossain, Tim Illidge, Michael Karin, Howard L Kaufman, Oliver Kepp, Guido Kroemer, Juan Jose Lasarte, Sherene Loi, Michael T Lotze, Gwenola Manic, Taha Merghoub, Alan A Melcher, Karen L Mossman, Felipe Prosper, Øystein Rekdal, Maria Rescigno, Chiara Riganti, Antonella Sistigu, Mark J Smyth, Radek Spisek, John Stagg, Bryan E Strauss, Daolin Tang, Kazuki Tatsuno, Stefaan W van Gool, Peter Vandenabeele, Takahiro Yamazaki, Dmitriy Zamarin, Laurence Zitvogel, Alessandra Cesano, Francesco M Marincola. https://jitc.bmj.com/content/8/1/e000337

A20 and Cell Death-driven InflammationDario Priem, Geert van Loo, Mathieu J.M. Bertrand. https://www.cell.com/trends/immunology/fulltext/S1471-4906(20)30039-9#.XoiGl7hWlh0.twitter

Necroptosis and its role in infectious diseases – Xiaojing Xia, Liancheng Lei, Song Wang, Jianhe Hu and Gaiping Zhang. https://link.springer.com/article/10.1007/s10495-019-01589-x

Dark Side of Cytotoxic Therapy: Chemoradiation-Induced Cell Death and Tumor Repopulation – Ming-jie Jiang, Dian-na Gu, Juan-juan Dai, Qian Huang, Ling Tian. https://www.cell.com/trends/cancer/fulltext/S2405-8033(20)30057-1

Caspases in Cell Death, Inflammation, and Pyroptosis – Sannula Kesavardhana, R.K. Subbarao Malireddi, and Thirumala-Devi Kanneganti. https://www.annualreviews.org/doi/abs/10.1146/annurev-immunol-073119-095439

Book series at International Review of Cell and Molecular Biology: Cell Death Regulation in Health and Disease

Preface: Life through death—Key role of cellular suicide for colonial and organismal homeostasis – Johan Spetz, Lorenzo Galluzzi. https://www.sciencedirect.com/science/article/pii/S1937644820300356

Chapter One – Bcl-2 family proteins, beyond the veil – Jason Andrew Glab, Zhipeng Cao, Hamsa Puthalakath. https://www.sciencedirect.com/science/article/pii/S1937644819301200

Chapter Two – Mcl-1 as a “barrier” in cancer treatment: Can we target it now? – Nikolay V. Pervushin, Viacheslav V. Senichkin, Boris Zhivotovsky, Gelina S. Kopeina. https://www.sciencedirect.com/science/article/pii/S1937644820300022

Chapter Three – TRAIL receptor signaling: From the basics of canonical signal transduction toward its entanglement with ER stress and the unfolded protein response – Daniela Stöhr, Albert Jeltsch, Markus Rehm. https://www.sciencedirect.com/science/article/pii/S1937644820300071

Chapter Four – Type 3 IP3 receptors: The chameleon in cancer – Nicolas Rosa, Flore Sneyers, Jan B. Parys, Geert Bultynck. https://www.sciencedirect.com/science/article/pii/S1937644820300083

Chapter Five – On the role of sphingolipids in cell survival and death – Elisabetta Iessi, Matteo Marconi, Valeria Manganelli, Maurizio Sorice, … Paola Matarrese. https://www.sciencedirect.com/science/article/pii/S1937644820300095

Chapter Six – A lipid perspective on regulated cell death – Hector Flores-Romero, Uris Ros, Ana J. García-Sáez. https://www.sciencedirect.com/science/article/pii/S1937644819301170 

Part B

Chapter One – The mechanisms and cell signaling pathways of programmed cell death in the bacterial world – Robert P. Smith, Ivana Barraza, Rebecca J. Quinn, Marla C. Fortoul. https://doi.org/10.1016/bs.ircmb.2019.12.002

Chapter Two – Transcriptional and epigenetic control of regulated cell death in yeast – Andreas Zimmermann, Jelena Tadic, Katharina Kainz, Sebastian J. Hofer, … Frank Madeo. https://doi.org/10.1016/bs.ircmb.2019.12.003

Chapter Three – Cell death in the avian brain with emphasis on the development and plasticity of the song control system – Tracy A. Larson. https://doi.org/10.1016/bs.ircmb.2020.01.001

Chapter Four – Crosstalk between apoptosis and autophagy signaling pathways – W. Douglas Fairlie, Sharon Tran, Erinna F. Lee. https://doi.org/10.1016/bs.ircmb.2020.01.003

Chapter Five – The interplay of autophagy and non-apoptotic cell death pathways – Dannah R. Miller, Scott D. Cramer, Andrew Thorburn. https://doi.org/10.1016/bs.ircmb.2019.12.004

Chapter Six – Redox signaling in the pathogenesis of human disease and the regulatory role of autophagy – Shazib Pervaiz, Gregory L. Bellot, Antoinette Lemoine, Catherine Brenner. https://doi.org/10.1016/bs.ircmb.2020.03.002

Part C

Chapter One – Poly (ADP-ribose) (PAR)-dependent cell death in neurodegenerative diseases – Hyejin Park, Tae-In Kam, Ted M. Dawson, Valina L. Dawson. https://doi.org/10.1016/bs.ircmb.2019.12.009

Chapter Two – Molecular mechanisms of necroptosis and relevance for neurodegenerative diseases – Pedro A. Dionísio, Joana D. Amaral, Cecília M.P. Rodrigues. https://doi.org/10.1016/bs.ircmb.2019.12.006

Chapter Three – Necroptosis, ADAM proteases and intestinal (dys)function – Michelle Heib, Stefan Rose-John, Dieter Adam. https://doi.org/10.1016/bs.ircmb.2020.02.001

Chapter Four – Regulation of cell death in the cardiovascular system – Pooja Patel, Jason Karch. https://doi.org/10.1016/bs.ircmb.2019.11.005

Chapter Five – The involvement of regulated cell death forms in modulating the bacterial and viral pathogenesis – Gergely Imre. https://doi.org/10.1016/bs.ircmb.2019.12.008

Chapter Six – A connection in life and death: The BCL-2 family coordinates mitochondrial network dynamics and stem cell fate – Megan L. Rasmussen, Vivian Gama. https://doi.org/10.1016/bs.ircmb.2019.12.005


Not So FASt: Tumor Cells Resisting Death Drive CAR T-cell Dysfunction – Michael R. Green and Sattva S. Neelapu. https://cancerdiscovery.aacrjournals.org/content/10/4/492

Immunogenicity of cell death driven by immune effectorsLorenzo Galluzzi, Giulia Petroni, Guido Kroemer. https://jitc.bmj.com/content/8/1/e000802

Programmed death, cells on the last train to glory – Patrycja Nowak-Sliwinska and Arjan W. Griffioen. https://link.springer.com/article/10.1007/s10495-020-01598-1

ApoList – March 2020

Research is important. Keep strong everyone


Death receptors

TRAIL Receptors Serve as Stress-Associated Molecular Patterns to Promote ER-Stress-Induced Inflammation – Graeme P. Sullivan, Hazel O’Connor, Conor M. Henry, Pavel Davidovich, Danielle M. Clancy, Matthew L. Albert, Sean P. Cullen, Seamus J. Martin. https://www.cell.com/developmental-cell/fulltext/S1534-5807(20)30063-0

A20 Promotes Ripoptosome Formation and TNF-Induced Apoptosis via cIAPs Regulation and NIK Stabilization in Keratinocytes – Maria Feoktistova, Roman Makarov, Sihem Brenji, Anne T. Schneider, Guido J. Hooiveld, Tom Luedde, Martin Leverkus, Amir S. Yazdi and Diana Panayotova-Dimitrova. https://www.mdpi.com/2073-4409/9/2/351

Targeting the Extrinsic Pathway of Hepatocyte Apoptosis Promotes Clearance of Plasmodium Liver Infection – Gregor Ebert, Sash Lopaticki, Matthew T. O’Neill, Ryan W.J. Steel, Marcel Doerflinger, Pravin Rajasekaran, Annie S.P. Yang, Sara Erickson, Lisa Ioannidis, Philip Arandjelovic, Liana Mackiewicz, Cody Allison, John Silke, Marc Pellegrini, Justin A. Boddey. https://www.cell.com/cell-reports/fulltext/S2211-1247(20)30346-6

Caspases and cFLIP

Cancer Cells Employ Nuclear Caspase-8 to Overcome the p53-Dependent G2/M Checkpoint through Cleavage of USP28 – Ines Müller, Elwira Strozyk, Sebastian Schindler, Stefan Beissert, Htoo Zarni Oo, Thomas Sauter, Philippe Lucarelli, Sebastian Raeth, Angelika Hausser, Nader Al Nakouzi, Ladan Fazli, Martin E. Gleave, He Liu, Hans-Uwe Simon, Henning Walczak, Douglas R. Green, Jiri Bartek, Mads Daugaard, Dagmar Kulms. https://www.cell.com/molecular-cell/fulltext/S1097-2765(19)30953-0

Cross-regulation between LUBAC and caspase-1 modulates cell death and inflammation – Todd Douglas and Maya Saleh. http://www.jbc.org/content/early/2020/03/02/jbc.RA119.011622.abstract

Gastermins and pyroptosis

Gasdermin E suppresses tumour growth by activating anti-tumour immunity – Zhibin Zhang, Ying Zhang, Shiyu Xia, Qing Kong, Shunying Li, Xing Liu, Caroline Junqueira, Karla F. Meza-Sosa, Temy Mo Yin Mok, James Ansara, Satyaki Sengupta, Yandan Yao, Hao Wu and Judy Lieberman. https://www.nature.com/articles/s41586-020-2071-9

cFLIPL protects macrophages from LPS-induced pyroptosis via inhibition of complex II formation – Hayley I. Muendlein, David Jetton, Wilson M. Connolly, Keith P. Eidell, Zoie Magri, Irina Smirnova, Alexander Poltorak. https://science.sciencemag.org/content/367/6484/1379

A bioorthogonal system reveals antitumour immune function of pyroptosis – Qinyang Wang, Yupeng Wang, Jingjin Ding, Chunhong Wang, Xuehan Zhou, Wenqing Gao, Huanwei Huang, Feng Shao and Zhibo Liu. https://www.nature.com/articles/s41586-020-2079-1

Structural Mechanism for GSDMD Targeting by Autoprocessed Caspases in Pyroptosis – Kun Wang, Qi Sun, Xiu Zhong, Mengxue Zeng, Huan Zeng, Xuyan Shi, Zilin Li, Yupeng Wang, Qiang Zhao, Feng Shao, Jingjin Ding. https://www.cell.com/cell/fulltext/S0092-8674(20)30146-X

Mitochondrial GSDMD Pores DAMPen Pyroptosis – Katherine C. Barnett, Jenny P.-Y. Ting. https://www.cell.com/immunity/fulltext/S1074-7613(20)30083-2

mtDNA Activates cGAS Signaling and Suppresses the YAP-Mediated Endothçelial Cell Proliferation Program to Promote Inflammatory Injury – Long Shuang Huang, Zhigang Hong, Wei Wu, Shiqin Xiong, Ming Zhong, Xiaopei Gao, Jalees Rehman, Asrar B. Malik. https://www.cell.com/immunity/fulltext/S1074-7613(20)30083-2

A bioorthogonal system reveals antitumour immune function of pyroptosis – Qinyang Wang, Yupeng Wang, Jingjin Ding, Chunhong Wang, Xuehan Zhou, Wenqing Gao, Huanwei Huang, Feng Shao and Zhibo Liu. https://www.nature.com/articles/s41586-020-2079-1

Bcl-2 family proteins

A small-molecule allosteric inhibitor of BAX protects against doxorubicin-induced cardiomyopathy – Dulguun Amgalan, Thomas P. Garner, Ryan Pekson, Xiaotong F. Jia, Mounica Yanamandala, Victor Paulino, Felix G. Liang, J. Jose Corbalan, Jaehoon Lee, Yun Chen, George S. Karagiannis, Luis Rivera Sanchez, Huizhi Liang, Swathi-Rao Narayanagari, Kelly Mitchell, Andrea Lopez, Victoria Margulets, Marco Scarlata, Gaetano Santulli, Aarti Asnani, Randall T. Peterson, Rachel B. Hazan, John S. Condeelis, Maja H. Oktay, Ulrich Steidl, Lorrie A. Kirshenbaum, Evripidis Gavathiotis and Richard N. Kitsis. https://www.nature.com/articles/s43018-020-0039-1

Site-Dependent Cysteine Lipidation Potentiates the Activation of Proapoptotic BAX – Daniel T. Cohen, Thomas E. Wales, Matthew W. McHenry, John R. Engen, Loren D. Walensky. https://www.cell.com/cell-reports/fulltext/S2211-1247(20)30225-4

Low expression of pro-apoptotic proteins Bax, Bak and Smac indicates prolonged progression-free survival in chemotherapy-treated metastatic melanoma – Cristiano Guttà, Arman Rahman, Claudia Aura, Peter Dynoodt, Emilie M. Charles, Elodie Hirschenhahn, Jesuchristopher Joseph, Jasper Wouters, Ciaran de Chaumont, Mairin Rafferty, Madhuri Warren, Joost J. van den Oord, William M. Gallagher and Markus Rehm. https://www.nature.com/articles/s41419-020-2309-3

SFTSV Infection Induces BAK/BAX-Dependent Mitochondrial DNA Release to Trigger NLRP3 Inflammasome Activation – Shufen Li, Hao Li, Yu-Lan Zhang, Qi-Lin Xin, Zhen-Qiong Guan, Xi Chen, Xiao-Ai Zhang, Xiao-Kun Li, Geng-Fu Xiao, Pierre-Yves Lozach, Jun Cui, Wei Liu, Lei-Ke Zhang, Ke Peng. https://www.cell.com/cell-reports/fulltext/S2211-1247(20)30286-2

Combined reduction in the expression of MCL-1 and BCL-2 reduces organismal size in mice – Francine Ke, Graeme I. Lancaster, Stephanie Grabow, Andrew J. Murphy and Andreas Strasser. https://www.nature.com/articles/s41419-020-2376-5

MCL1 is Required for Maintenance of Intestinal Homeostasis and Prevention of Carcinogenesis in Mice – Marc E. Healy, Yannick Boege, Michael C. Hodder, Friederike Böhm, Mohsen Malehmir, Anna-Lena Scherr, Jasna Jetzer, Lap Kwan Chan, Rossella Parrotta, Kurt Jacob, Laure-Alix Clerbaux, Susanne Kreutzer, Andrew Campbell, Ella Gilchrist, Kathryn Gilroy, Ann-Katrin Rodewal , Hanna Honcharova-Biletska, Roman Schimmer, Karelia Vélez, Simone Büeler, Patrizia Cammareri , Gabriela Kalna, Anna S. Wenning, Kathy D. McCoy, Mercedes Gomez de Agüero, Henning Schulze-Bergkamen, Christoph Klose, Kristian Unger, Andrew J. Macpherson , Andreas E. Moor, Bruno Köhler, Owen J. Sanso, Mathias Heikenwalder, Achim Weber. https://www.gastrojournal.org/article/S0016-5085(20)30338-3/fulltext

HUWE1 controls MCL1 stability to unleash AMBRA1-induced mitophagyFlavie Strappazzon, Anthea Di Rita, Angelo Peschiaroli, Pier Paolo Leoncini, Franco Locatelli, Gerry Melino and Francesco Cecconi. https://www.nature.com/articles/s41418-019-0404-8

MCL1 binding to the reverse BH3 motif of P18INK4C couples cell survival to cell proliferation – Robert H. Whitaker and William J. Placzek. https://www.nature.com/articles/s41419-020-2351-1

MCL1 inhibition is effective against a subset of small-cell lung cancer with high MCL1 and low BCL-XL expression – Yuto Yasuda, Hiroaki Ozasa, Young Hak Kim, Masatoshi Yamazoe, Hitomi Ajimizu, Tomoko Yamamoto Funazo, Takashi Nomizo, Takahiro Tsuji, Hironori Yoshida, Yuichi Sakamori, Naoki Nakajima, Toshi Menju, Akihiko Yoshizawa, Hiroshi Date and Toyohiro Hirai. https://www.nature.com/articles/s41419-020-2379-2

Conformational Switching in Bcl-xL: Enabling Non-Canonic Inhibition of Apoptosis Involves Multiple Intermediates and Lipid Interactions – Victor Vasquez-Montes, Alexander Kyrychenko, Mauricio Vargas-Uribe, Mykola V. Rodnin and Alexey S. Ladokhin. https://www.mdpi.com/2073-4409/9/3/539

Electron transport chain activity is a predictor and target for venetoclax sensitivity in multiple myeloma – Richa Bajpai, Aditi Sharma, Abhinav Achreja, Claudia L. Edgar, Changyong Wei, Arusha A. Siddiqa, Vikas A. Gupta, Shannon M. Matulis, Samuel K. McBrayer, Anjali Mittal, Manali Rupji, Benjamin G. Barwick, Sagar Lonial, Ajay K. Nooka, Lawrence H. Boise, Deepak Nagrath and Mala Shanmugam. https://www.nature.com/articles/s41467-020-15051-z


Sequential activation of necroptosis and apoptosis cooperates to mediate vascular and neural pathology in stroke – Masanori Gomi Naito, Daichao Xu, Palak Amin, Jinwoo Lee, Huibing Wang, Wanjin Li, Michelle Kelliher, Manolis Pasparakis, and Junying Yuan. https://www.pnas.org/content/117/9/4959.abstract?etoc

Z-nucleic-acid sensing triggers ZBP1-dependent necroptosis and inflammation – Huipeng Jiao, Laurens Wachsmuth, Snehlata Kumari, Robin Schwarzer, Juan Lin, Remzi Onur Eren, Amanda Fisher, Rebecca Lane, George R. Young, George Kassiotis, William J. Kaiser and Manolis Pasparakis. https://www.nature.com/articles/s41586-020-2129-8

Gut stem cell necroptosis by genome instability triggers bowel inflammation – Ruicong Wang, Hongda Li, Jianfeng Wu, Zhi-Yu Cai, Baizhou Li, Hengxiao Ni, Xingfeng Qiu, Hui Chen, Wei Liu, Zhang-Hua Yang, Min Liu, Jin Hu, Yaoji Liang, Ping Lan, Jiahuai Han and Wei Mo. https://www.nature.com/articles/s41586-020-2127-x

Inhibition of keratinocyte necroptosis mediated by RIPK1/RIPK3/MLKL provides a protective effect against psoriatic inflammation – Xiaoru Duan, Xinxin Liu, Nian Liu, Yuqiong Huang, Zilin Jin, Song Zhang, Zhangyin Ming and Hongxiang Chen. https://www.nature.com/articles/s41419-020-2328-0

Necroptosis-blocking compound NBC1 targets heat shock protein 70 to inhibit MLKL polymerization and necroptosis – Andrea N. Johnston, Yuyong Ma, Hua Liu, Shuzhen Liu, Sarah Hanna-Addams, She Chen, Chuo Chen and Zhigao Wang. https://www.pnas.org/content/117/12/6521.abstract?etoc

Influenza Virus Z-RNAs Induce ZBP1-Mediated Necroptosis – Ting Zhang, Chaoran Yin, David F. Boyd, Giovanni Quarato, Justin P. Ingram, Maria Shubina, Katherine B. Ragan, Takumi Ishizuka, Jeremy Chase Crawford, Bart Tummers, Diego A. Rodriguez, Jia Xue, Suraj Peri, William J. Kaiser, Carolina B. López, Yan Xu, Jason W. Upton, Paul G. Thomas, Douglas R. Green, Siddharth Balachandran. https://www.cell.com/cell/fulltext/S0092-8674(20)30227-0

The necroptosis machinery mediates axonal degeneration in a model of Parkinson diseaseMaritza Oñate, Alejandra Catenaccio, Natalia Salvadores, Cristian Saquel, Alexis Martinez, Ines Moreno-Gonzalez, Nazaret Gamez, Paulina Soto, Claudio Soto, Claudio Hetz and Felipe A. Court. https://www.nature.com/articles/s41418-019-0408-4


Transferrin Receptor Is a Specific Ferroptosis Marker – Huizhong Feng, Kenji Schorpp, Jenny Jin, Carrie E. Yozwiak, Benjamin G. Hoffstrom, Aubrianna M. Decker, Presha Rajbhandari, Michael E. Stokes, Hannah G. Bender, Joleen M. Csuka, Pavan S. Upadhyayula, Peter Canoll, Koji Uchida, Rajesh K. Soni, Kamyar Hadian, Brent R. Stockwell. https://www.cell.com/cell-reports/fulltext/S2211-1247(20)30210-2

Mitochondrial DNA stress triggers autophagy-dependent ferroptotic death – Li C, Zhang Y, Liu J, Kang R, Klionsky DJ, Tang D. https://www.tandfonline.com/doi/full/10.1080/15548627.2020.1739447

Caspase-1 interdomain linker cleavage is required for pyroptosis – Daniel P Ball, Cornelius Y Taabazuing, Andrew R Griswold, Elizabeth L Orth, Sahana D Rao, Ilana B Kotliar, Lauren E Vostal, Darren C Johnson and Daniel A Bachovchin. https://www.life-science-alliance.org/content/3/3/e202000664.abstract

Efferocytosis and cell-cell effects

Metabolites released from apoptotic cells act as tissue messengers – Christopher B. Medina, Parul Mehrotra, Sanja Arandjelovic, Justin S. A. Perry, Yizhan Guo, Sho Morioka, Brady Barron, Scott F. Walk, Bart Ghesquière, Alexander S. Krupnick, Ulrike Lorenz and Kodi S. Ravichandran. https://www.nature.com/articles/s41586-020-2121-3

Macrophage Metabolism of Apoptotic Cell-Derived Arginine Promotes Continual Efferocytosis and Resolution of Injury – Arif Yurdagul Jr., Manikandan Subramanian, Xiaobo Wang, Scott B. Crown, Olga R. Ilkayeva, Lancia Darville, Gopi K. Kolluru, Christina C. Rymond, Brennan D. Gerlach, Ze Zheng, George Kuriakose, Christopher G. Kevil, John M. Koomen, John L. Cleveland, Deborah M. Muoio, Ira Tabas. https://www.sciencedirect.com/science/article/abs/pii/S1550413120300012


In vivo detection of programmed cell death during mouse heart development – Kristel Martínez-Lagunas, Yoshifumi Yamaguchi, Cora Becker, Caroline Geisen, Marco C. DeRuiter, Masayuki Miura, Bernd K. Fleischmann and Michael Hesse. https://www.nature.com/articles/s41418-019-0426-2


Classification and Nomenclature of Metacaspases and Paracaspases: No More Confusion with Caspases – Elena A. Minina, Jens Staal, Vanina E. Alvarez, John A. Berges, Ilana Berman-Frank, Rudi Beyaert, Kay D. Bidle, Frédéric Bornancin, Magali Casanova, Juan J. Cazzulo, Chang Jae Choi, Nuria S. Coll, Vishva M. Dixit, Marko Dolinar, Nicolas Fasel, Christiane Funk, Patrick Gallois, Kris Gevaert, Emilio Gutierrez-Beltran, Stephan Hailfinger, Marina Klemenčič, Eugene V. Koonin, Daniel Krappmann, Anna Linusson, Maurício F.M. Machado, Frank Madeo, Lynn A. Megeney, Panagiotis N. Moschou, Jeremy C. Mottram, Thomas Nyström, Heinz D. Osiewacz, Christopher M. Overall, Kailash C. Pandey, Jürgen Ruland, Guy S. Salvesen, Yigong Shi, Andrei Smertenko, Simon Stael, Jerry Ståhlberg, María Fernanda Suárez, Margot Thome, Hannele Tuominen, Frank Van Breusegem, Renier A.L. van der Hoorn, Assaf Vardi, Boris Zhivotovsky, Eric Lam, Peter V. Bozhkov. https://www.cell.com/molecular-cell/fulltext/S1097-2765(19)30950-5

Investigating Nonapoptotic Cell Death Using Chemical Biology Approaches – David A. Armenta, Scott J. Dixon. https://www.cell.com/cell-chemical-biology/fulltext/S2451-9456(20)30079-9

Ferroptosis: past, present and future – Jie Li, Feng Cao, He-liang Yin, Zi-jian Huang, Zhi-tao Lin, Ning Mao, Bei Sun and Gang Wang. https://www.nature.com/articles/s41419-020-2298-2

Restoring Apoptosis with BH3 Mimetics in Mature B-Cell Malignancies – Maxime Jullien, Patricia Gomez-Bougie, David Chiron and Cyrille Touzeau. https://www.mdpi.com/2073-4409/9/3/717


Ghostly metabolic messages from dying cells – Douglas R. Green. https://www.nature.com/articles/d41586-020-00641-0

ER Stress Leaves an Inflammatory TRAIL – Alba Roca Portoles, Stephen W.G. Tait. https://www.cell.com/developmental-cell/fulltext/S1534-5807(20)30188-X

Appetite for Arginine: Metabolic Control of Macrophage Hunger – Daniel J. Puleston, Erika L. Pearce. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(20)30064-4

TAMing efferocytosis to fight tumors – Christopher B. Rodell. https://stm.sciencemag.org/content/12/533/eabb0795

Destroying tumors with pyroptosis – John F. Foley. https://stke.sciencemag.org/content/13/624/eabb8244

ApoList – February 2020

Dear all,

Please allow me to advertise this service in case you want to do your personalized ApoList, or a weekly list of interesting articles on any topic. Biomed News (www.biomed.news) proposes you new records in PubMed every week, ranked by machine learning. You select your favorite items, they are sent to you via email, and you can then disseminate the weekly list yourself. Other users can browse it at  http://biomed.news/reports



Bcl-2 family proteins

STING-dependent paracriny shapes apoptotic priming of breast tumors in response to anti-mitotic treatment – Steven Lohard, Nathalie Bourgeois, Laurent Maillet, Fabien Gautier, Aurélie Fétiveau, Hamza Lasla, Frédérique Nguyen, Céline Vuillier, Alison Dumont, Agnès Moreau-Aubry, Morgane Frapin, Laurent David, Delphine Loussouarn, Olivier Kerdraon, Mario Campone, Pascal Jézéquel, Philippe P. Juin and Sophie Barillé-Nion. https://www.nature.com/articles/s41467-019-13689-y

Allosteric Regulation of BH3 Proteins in Bcl-xL Complexes Enables Switch-like Activation of Bax – Christian Bogner, Justin Kale, Justin Pogmore, Xiaoke Chi, Aisha Shamas-Din, Cécile Fradin, Brian Leber, David W. Andrews. https://www.cell.com/molecular-cell/fulltext/S1097-2765(19)30955-4

A selective BCL-XL PROTAC degrader achieves safe and potent antitumor activity – Sajid Khan, Xuan Zhang, Dongwen Lv, Qi Zhang, Yonghan He, Peiyi Zhang, Xingui Liu, Dinesh Thummuri, Yaxia Yuan, Janet S. Wiegand, Jing Pei, Weizhou Zhang, Abhisheak Sharma, Christopher R. McCurdy, Vinitha M. Kuruvilla, Natalia Baran, Adolfo A. Ferrando, Yong-mi Kim, Anna Rogojina, Peter J. Houghton, Guangcun Huang, Robert Hromas, Marina Konopleva, Guangrong Zheng and Daohong Zhou. https://www.nature.com/articles/s41591-019-0668-z

Overexpression of Antiapoptotic MCL-1 Predicts Worse Overall Survival of Patients With Non-small Cell Lung Cancer – Nakano T, Go T, Nakashima N, Liu D, Yokomise H. http://ar.iiarjournals.org/content/40/2/1007.abstract

Potent efficacy of MCL-1 inhibitor-based therapies in preclinical models of mantle cell lymphoma – Michael A. Dengler, Charis E. Teh, Rachel Thijssen, Lahiru Gangoda, Ping Lan, Marco J. Herold, Daniel H. Gray, Gemma L. Kelly, Andrew W. Roberts and Jerry M. Adams. https://www.nature.com/articles/s41388-019-1122-x

Aurora A Kinase Inhibition Destabilizes PAX3-FOXO1 and MYCN and Synergizes with Navitoclax to Induce Rhabdomyosarcoma Cell Death – Johannes Ommer, Joanna L. Selfe, Marco Wachtel, Eleanor M. O’Brien, Dominik Laubscher, Michaela Roemmele, Stephanie Kasper, Olivier Delattre, Didier Surdez, Gemma Petts, Anna Kelsey, Janet Shipley and Beat W. Schäfer. https://cancerres.aacrjournals.org/content/80/4/832

MCL-1 antagonism enhances the anti-invasive effects of dasatinib in pancreatic adenocarcinoma – Lesley Castillo, Adelaide I. J. Young, Amanda Mawson, Pia Schafranek, Angela M. Steinmann, Danielle Nessem, Ashleigh Parkin, Amber Johns, Angela Chou, Andrew M. K. Law, Morghan C. Lucas, Kendelle J. Murphy, Niantao Deng, David Gallego-Ortega, Catherine E. Caldon, Australian Pancreatic Cancer Genome Initiative (APGI), Paul Timpson, Marina Pajic, Christopher J. Ormandy and Samantha R. Oakes. https://www.nature.com/articles/s41388-019-1091-0

Dynamic PGAM5 multimers dephosphorylate BCL-xL or FUNDC1 to regulate mitochondrial and cellular fate – Kaili Ma, Zhi Zhang, Rui Chang, Hongcheng Cheng, Chenglong Mu, Tian Zhao, Linbo Chen, Chuanmei Zhang, Qian Luo, Jialing Lin, Yushan Zhu and Quan Chen. https://www.nature.com/articles/s41418-019-0396-4

Death receptors

Long and short isoforms of c-FLIP act as control checkpoints of DED filament assembly – Laura K. Hillert, Nikita V. Ivanisenko, Johannes Espe, Corinna König, Vladimir A. Ivanisenko, Thilo Kähne and Inna N. Lavrik. https://www.nature.com/articles/s41388-019-1100-3

The parkin-coregulated gene product PACRG promotes TNF signaling by stabilizing LUBAC – Jens Meschede , Maria Šadić, Nikolas Furthmann, Tim Miedema, Dominik A. Sehr, A. Kathrin Müller-Rischart, Verian Bader, Lena A. Berlemann, Anna Pilsl, Anita Schlierf, Katalin Barkovits, Barbara Kachholz, Katrin Rittinger, Fumiyo Ikeda, Katrin Marcus, Liliana Schaefer, Jörg Tatzelt, Konstanze F. Winklhofer. https://stke.sciencemag.org/content/13/617/eaav1256

Cell death induced by the ER stressor thapsigargin involves death receptor 5, a non-autophagic function of MAP1LC3B, and distinct contributions from unfolded protein response components – Lindner P, Christensen SB, Nissen P, Møller JV, Engedal N. https://biosignaling.biomedcentral.com/articles/10.1186/s12964-019-0499-z

OTULIN Prevents Liver Inflammation and Hepatocellular Carcinoma by Inhibiting FADD- and RIPK1 Kinase-Mediated Hepatocyte Apoptosis – Lien Verboom, Arne Martens, Dario Priem, Esther Hoste, Mozes Sze, Hanna Vikkula, Lisette Van Hove, Sofie Voet, Jana Roels, Jonathan Maelfait, Laura Bongiovanni, Alain de Bruin, Charlotte L. Scott, Yvan Saeys, Manolis Pasparakis, Mathieu J.M. Bertrand, Geert van Loo. https://www.cell.com/cell-reports/fulltext/S2211-1247(20)30037-1


E2F-Family Members Engage the PIDDosome to Limit Hepatocyte Ploidy in Liver Development and Regeneration – Valentina C. Sladky, Katja Knapp, Claudia Soratroi, Julia Heppke, Felix Eichin, Lourdes Rocamora-Reverte, Tamas G. Szabo, Laura Bongiovanni, Bart Westendorp, Eva Moreno, Elsbeth A. van Liere, Bjorn Bakker, Diana C.J. Spierings, René Wardenaar, David Pereyra, Patrick Starlinger, Simon Schultze, Michael Trauner, Tatjana Stojakovic, Hubert Scharnagl, Luca L. Fava, Floris Foijer, Alain de Bruin, Andreas Villunger. https://www.cell.com/developmental-cell/fulltext/S1534-5807(19)31039-1

Opposing effects of polysulfides and thioredoxin on apoptosis through caspase persulfidation – Ilana Braunstein, Rotem Engelman, Ofer Yitzhaki, Tamar Ziv, Erwan Galardon and Moran Benhar. http://www.jbc.org/content/early/2020/02/10/jbc.RA119.012357.abstract

An AMPK–caspase-6 axis controls liver damage in nonalcoholic steatohepatitis – Peng Zhao, Xiaoli Sun, Cynthia Chaggan, Zhongji Liao, Kai in Wong, Feng He, Seema Singh, Rohit Loomba, Michael Karin, Joseph L. Witztum, Alan R. Saltiel. https://science.sciencemag.org/content/367/6478/652

Necroptosis and RIP kinases

RIP1 kinase activity is critical for skin inflammation but not for viral propagation – Joshua D. Webster  Youngsu C. Kwon  Summer Park  Hua Zhang  Nick Corr  Nina Ljumanovic  Adeyemi O. Adedeji  Eugene Varfolomeev  Tatiana Goncharov  Jessica Preston  Sara F. Santagostino  Snahel Patel  Min Xu  Jonathan Maher  Brent S. McKenzie  Domagoj Vucic. https://jlb.onlinelibrary.wiley.com/doi/full/10.1002/JLB.3MA1219-398R

Phenotypic high-throughput screening platform identifies novel chemotypes for necroptosis inhibition – Hugo Brito, Vanda Marques, Marta B. Afonso, Dean G. Brown, Ulf Börjesson, Nidhal Selmi, David M. Smith, Ieuan O. Roberts, Martina Fitzek, Natália Aniceto, Rita C. Guedes, Rui Moreira and Cecília M. P. Rodrigues. https://www.nature.com/articles/s41420-020-0240-0


Energy-stress-mediated AMPK activation inhibits ferroptosis – Hyemin Lee, Fereshteh Zandkarimi, Yilei Zhang, Jitendra Kumar Meena, Jongchan Kim, Li Zhuang, Siddhartha Tyagi, Li Ma, Thomas F. Westbrook, Gregory R. Steinberg, Daisuke Nakada, Brent R. Stockwell and Boyi Gan. https://www.nature.com/articles/s41556-020-0461-8


Cell Death in Cells Overlying Lateral Root Primordia Facilitates Organ Growth in Arabidopsis – Sacha Escamez, Domenique André, Bernadette Sztojka, Benjamin Bollhöner, Hardy Hall, Béatrice Berthet, Ute Voß, Amnon Lers, Alexis Maizel, Magnus Andersson, Malcolm Bennett, Hannele Tuominen. https://www.cell.com/current-biology/fulltext/S0960-9822(19)31580-5

Coordinated changes in cell membrane and cytoplasm during maturation of apoptotic bleb – Kana Aoki, Shinsuke Satoi, Shota Harada, Seiichi Uchida, Yoh Iwasa, and Junichi Ikenouchi. https://www.molbiolcell.org/doi/10.1091/mbc.E19-12-0691?ai=25zg&ui=2oy6&af=T

Control of cell death/survival balance by the MET dependence receptor – Leslie Duplaquet, Catherine Leroy, Audrey Vinchent, Sonia Paget, Jonathan Lefebvre, Fabien Vanden Abeele, Steve Lancel, Florence Giffard, Réjane Paumelle, Gabriel Bidaux, Laurent Heliot, Laurent Poulain, Alessandro Furlan, David Tulasne. https://elifesciences.org/articles/50041


RIPK1 Kinase-Dependent Death: A Symphony of Phosphorylation Events – Tom Delanghe, Yves Dondelinger, Mathieu J.M. Bertrand. https://www.cell.com/trends/cell-biology/fulltext/S0962-8924(19)30223-5

SMAC mimetics and RIPK inhibitors as therapeutics for chronic inflammatory diseases – Simone Jensen, Jakob Benedict Seidelin, Eric Charles LaCasse, and Ole Haagen Nielsen. https://stke.sciencemag.org/content/13/619/eaax8295


Mechanisms for Ca2+-dependent permeability transition in mitochondria – Paolo Bernardi. https://www.pnas.org/content/117/6/2743?etoc=

Reply to Bernardi: The mitochondrial permeability transition pore and the ATP synthase – John E. Walker, Joe Carroll, and Jiuya He. https://www.pnas.org/content/117/6/2745

Loss of ferritin in developing wing cells: Apoptosis and ferroptosis coincide – Anna Karen Hernández-Gallardo, Fanis Missirlis. https://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1008503

The PROTAC DT2216 Targets Cancer by Promoting BCL-XL Degradation – https://cancerdiscovery.aacrjournals.org/content/10/2/174.1

ApoList – January 2020

Immunogenicity of cell death

Quantitative and Dynamic Catalogs of Proteins Released during Apoptotic and Necroptotic Cell Death – Maria C. Tanzer, Annika Frauenstein, Che A. Stafford, Kshiti Phulphagar, Matthias Mann, Felix Meissner. https://www.cell.com/cell-reports/fulltext/S2211-1247(19)31744-9

Immunodominant AH1 Antigen-Deficient Necroptotic, but Not Apoptotic, Murine Cancer Cells Induce Antitumor Protection – Tania Løve Aaes, Hanne Verschuere, Agnieszka Kaczmarek, Liesbeth Heyndrickx, Bartosz Wiernicki, Iris Delrue, Bram De Craene, Joachim Taminau, Tinneke Delvaeye, Mathieu J. M. Bertrand, Wim Declercq, Geert Berx, Dmitri V. Krysko, Sandy Adjemian and Peter Vandenabeele. https://www.jimmunol.org/content/early/2020/01/02/jimmunol.1900072

Immune Sensing of Cell Death through Recognition of Histone Sequences by C-Type Lectin-Receptor-2d Causes Inflammation and Tissue Injury – Jiann-Jyh Lai, Freidrich M. Cruz, Kenneth L. Rock. https://www.cell.com/immunity/fulltext/S1074-7613(19)30494-7

Characterization of virus-mediated immunogenic cancer cell death and the consequences for oncolytic virus-based immunotherapy of cancer – Jing Ma, Mohanraj Ramachandran, Chuan Jin, Clara Quijano-Rubio, Miika Martikainen, Di Yu and Magnus Essand. https://www.nature.com/articles/s41419-020-2236-3

Death receptors

Misfolded proteins bind and activate death receptor 5 to induce apoptosis during unresolved endoplasmic reticulum stress – Mable Lam, Scot A Marsters, Avi Ashkenazi, Peter Walter. https://elifesciences.org/articles/52291

Heterogeneous responses to low level death receptor activation are explained by random molecular assembly of the Caspase-8 activation platform – Matveeva A, Fichtner M, McAllister K, McCann C, Sturrock M, Longley DB, Prehn JHM. https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1007374

Single-molecule imaging reveals the oligomeric state of functional TNFα-induced plasma membrane TNFR1 clusters in cells – Christos Karathanasis, Juliane Medler, Franziska Fricke, Sonja Smith, Sebastian Malkusch, Darius Widera, Simone Fulda, Harald Wajant, Sjoerd J. L. van Wijk, Ivan Dikic and Mike Heilemann. https://stke.sciencemag.org/content/13/614/eaax5647

Bcl-2 family proteins

Mitochondrial residence of the apoptosis inducer BAX is more important than BAX oligomerization in promoting membrane permeabilization – Tomomi Kuwana, Louise E King, Katia Cosentino, Julian Suess, Ana J. García-Sáez, Andrew P. Gilmore and Donald D Newmeyer. http://www.jbc.org/content/early/2020/01/03/jbc.RA119.011635.abstract

Dynein light chain binding determines complex formation and posttranslational stability of the Bcl-2 family members Bmf and Bim – Prafull Kumar Singh, Aristomenis Roukounakis, Arnim Weber, Kushal Kumar Das, Benedicte Sohm, Andreas Villunger, Ana J. Garcia-Saez and Georg Häcker. https://www.nature.com/articles/s41418-019-0365-y

Loss of Bcl-G, a Bcl-2 family member, augments the development of inflammation-associated colorectal cancer – Paul M. Nguyen, Laura F. Dagley, Adele Preaudet, Nga Lam, Maybelline Giam, Ka Yee Fung, Kaheina Aizel, Gemma van Duijneveldt, Chin Wee Tan, Yumiko Hirokawa, Hon Yan K. Yip, Christopher G. Love, Ashleigh R. Poh, Akshay D’ Cruz, Charlotte Burstroem, Rebecca Feltham, Suad M. Abdirahman, Kristy Meiselbach, Ronnie Ren Jie Low, Michelle Palmieri, Matthias Ernst, Andrew I. Webb, Tony Burgess, Oliver M. Sieber, Philippe Bouillet and Tracy L. Putoczki. https://www.nature.com/articles/s41418-019-0383-9

Human BCL-G regulates secretion of inflammatory chemokines but is dispensable for induction of apoptosis by IFN-γ and TNF-α in intestinal epithelial cells – Jerzy A. Woznicki, Peter Flood, Milan Bustamante-Garrido, Panagiota Stamou, Gerry Moloney, Aine Fanning, Syed Akbar Zulquernain, Jane McCarthy, Fergus Shanahan, Silvia Melgar and Ken Nally. https://www.nature.com/articles/s41419-020-2263-0

Characterization of a novel human BFL-1-specific monoclonal antibody – Lahiru Gangoda, Charis E. Teh, Michael A. Dengler, Sarah A. Best, Clare E. Weeden, Lin Tai, Erinna F. Lee, Walter D. Fairlie, Kate D. Sutherland, Leonard C. Harrison, Daniel H. Gray, Andreas Strasser and Marco J. Herold. https://www.nature.com/articles/s41418-019-0454-y

Bile acid-induced “Minority MOMP” promotes esophageal carcinogenesis while maintaining apoptotic resistance via Mcl-1 – Yuan Xu, Deborah R. Surman, Laurence Diggs, Sichuan Xi, Shaojian Gao, Devikala Gurusamy, Kaitlin McLoughlin, Justin Drake, Paul Feingold, Kate Brown, Danny Wangsa, Darawalee Wangsa, Xi Zhang, Thomas Ried, Jeremy L. Davis, Jonathan Hernandez, Chuong D. Hoang, Rhonda F. Souza, David S. Schrump and R. Taylor Ripley. https://www.nature.com/articles/s41388-019-1029-6

The carboxyl-terminal sequence of bim enables bax activation and killing of unprimed cells – Xiaoke Chi, Dang Nguyen, James M Pemberton, Elizabeth J Oesterlund, Qian Liu, Hetal Brahmbhatt, Zhi Zhang, Jialing Lin, Brian Leber, David W Andrews. https://elifesciences.org/articles/44525

Type 1 Innate Lymphoid Cells Protect Mice from Acute Liver Injury via Interferon-γ Secretion for Upregulating Bcl-xL Expression in Hepatocytes – Tsukasa Nabekura, Luke Riggan, Andrew D. Hildreth, Timothy E. O’Sullivan, Akira Shibuya. https://www.cell.com/immunity/fulltext/S1074-7613(19)30462-5


Exploring the prime site in caspases as a novel chemical strategy for understanding the mechanisms of cell death: a proof of concept study on necroptosis in cancer cells – Katarzyna Groborz, Monica L. Gonzalez Ramirez, Scott J. Snipas, Guy S. Salvesen, Marcin Drąg and Marcin Poręba. https://www.nature.com/articles/s41418-019-0364-z

Necroptosis / RIP kinases

CK1α, CK1δ, and CK1ε are necrosome components which phosphorylate serine 227 of human RIPK3 to activate necroptosis – Sarah Hanna-Addams, Shuzhen Liu, Hua Liu, She Chen and Zhigao Wang. https://www.pnas.org/content/117/4/1962.abstract?etoc

Casein kinase-1γ1 and 3 stimulate tumor necrosis factor-induced necroptosis through RIPK3 – Song-Yi Lee, Hyunjoo Kim, Cathena Meiling Li, Jaemin Kang, Ayaz Najafov, Muhah Jung, Soosung Kang, Shaomeng Wang, Junying Yuan and Yong-Keun Jung. https://www.nature.com/articles/s41419-019-2146-4

Constitutive Interferon Attenuates RIPK1/3-Mediated Cytokine Translation – Hayley I. Muendlein, Joseph Sarhan, Beiyun C. Liu, Wilson M. Connolly, Stephen A. Schworer, Irina Smirnova, Amy Y. Tang, Vladimir Ilyukha, Jodie Pietruska, Soroush Tahmasebi, Nahum Sonenberg, Alexei Degterev, Alexander Poltorak. https://www.cell.com/cell-reports/fulltext/S2211-1247(19)31730-9

Resolvin D1 promotes the targeting and clearance of necroptotic cells – Brennan D. Gerlach, Michael Marinello, Justin Heinz, Nicholas Rymut, Brian E. Sansbury, Colin O. Riley, Sudeshna Sadhu, Zeinab Hosseini, Yoko Kojima, Dale D. Tang, Nicholas J. Leeper, Matthew Spite, Margarida Barroso, Katey J. Rayner and Gabrielle Fredman. https://www.nature.com/articles/s41418-019-0370-1


ATF3 promotes erastin-induced ferroptosis by suppressing system Xc – Liyuan Wang, Yichen Liu, Tingting Du, Heng Yang, Lei Lei, Mengqi Guo, Han-Fei Ding, Junran Zhang, Hongbo Wang, Xiaoguang Chen and Chunhong Yan. https://www.nature.com/articles/s41418-019-0380-z


Programmed cell death along the midline axis patterns ipsilaterality in gastrulation – Lisandro Maya-Ramos, Takashi Mikawa. https://science.sciencemag.org/content/367/6474/197

Nuclear degradation dynamics in a nonapoptotic programmed cell death – Alla Yalonetskaya, Albert A. Mondragon, Zackary J. Hintze, Susan Holmes and Kimberly McCall. https://www.nature.com/articles/s41418-019-0382-x


Mitochondria as multifaceted regulators of cell death – Florian J. Bock and Stephen W. G. Tait. https://www.nature.com/articles/s41580-019-0173-8

Beyond inflammasomes: emerging function of gasdermins during apoptosis and NETosis – Kaiwen W Chen, Benjamin Demarco, Petr Broz. https://www.embopress.org/doi/abs/10.15252/embj.2019103397

Immunological impact of cell death signaling driven by radiation on the tumor microenvironment – Maria Esperanza Rodriguez-Ruiz, Ilio Vitale, Kevin J. Harrington, Ignacio Melero and Lorenzo Galluzzi. https://www.nature.com/articles/s41590-019-0561-4

Saga of Mcl-1: regulation from transcription to degradation – Viacheslav V. Senichkin, Alena Y. Streletskaia, Anna S. Gorbunova, Boris Zhivotovsky and Gelina S. Kopeina. https://www.nature.com/articles/s41418-019-0486-3


A matter of life and death for caspase 8 – Joseph Willson. https://www.nature.com/articles/s41580-019-0201-8

Clec2d Joins the Cell Death Sensor Ranks – Carlos del Fresno, David Sancho. https://www.cell.com/immunity/fulltext/S1074-7613(19)30534-5


ApoList – December 2019

Caspases and IAPs

Mutations that prevent caspase cleavage of RIPK1 cause autoinflammatory disease – Najoua Lalaoui, Steven E. Boyden, Hirotsugu Oda, Geryl M. Wood, Deborah L. Stone, Diep Chau, Lin Liu, Monique Stoffels, Tobias Kratina, Kate E. Lawlor, Kristien J. M. Zaal, Patrycja M. Hoffmann, Nima Etemadi, Kristy Shield-Artin, Christine Biben, Wanxia Li Tsai, Mary D. Blake, Hye Sun Kuehn, Dan Yang, Holly Anderton, Natasha Silke, Laurens Wachsmuth, Lixin Zheng, Natalia Sampaio Moura, David B. Beck, Gustavo Gutierrez-Cruz, Amanda K. Ombrello, Gineth P. Pinto-Patarroyo, Andrew J. Kueh, Marco J. Herold, Cathrine Hall, Hongying Wang, Jae Jin Chae, Natalia I. Dmitrieva, Mark McKenzie, Amanda Light, Beverly K. Barham, Anne Jones, Tina M. Romeo, Qing Zhou, Ivona Aksentijevich, James C. Mullikin, Andrew J. Gross, Anthony K. Shum, Edwin D. Hawkins, Seth L. Masters, Michael J. Lenardo, Manfred Boehm, Sergio D. Rosenzweig, Manolis Pasparakis, Anne K. Voss, Massimo Gadina, Daniel L. Kastner and John Silke. https://www.nature.com/articles/s41586-019-1828-5

A dominant autoinflammatory disease caused by non-cleavable variants of RIPK1 – Panfeng Tao, Jinqiao Sun, Zheming Wu, Shihao Wang, Jun Wang, Wanjin Li, Heling Pan, Renkui Bai, Jiahui Zhang, Ying Wang, Pui Y. Lee, Wenjing Ying, Qinhua Zhou, Jia Hou, Wenjie Wang, Bijun Sun, Mi Yang, Danru Liu, Ran Fang, Huan Han, Zhaohui Yang, Xin Huang, Haibo Li, Natalie Deuitch, Yuan Zhang, Dilan Dissanayake, Katrina Haude, Kirsty McWalter, Chelsea Roadhouse, Jennifer J. MacKenzie, Ronald M. Laxer, Ivona Aksentijevich, Xiaomin Yu, Xiaochuan Wang, Junying Yuan and Qing Zhou. https://www.nature.com/articles/s41586-019-1830-y

Cleaved Caspase-3 Transcriptionally Regulates Angiogenesis-Promoting Chemotherapy Resistance – Antoine Bernard, Sandy Chevrier, Françoise Beltjens, Magalie Dosset, Etienne Viltard, Anaïs Lagrange, Valentin Derangère, Alexandra Oudot, François Ghiringhelli, Bertrand Collin, Lionel Apetoh, Olivier Feron, Suzie Chen, Laurent Arnould, Frédérique Végran and Romain Boidot. https://cancerres-aacrjournals-org.sire.ub.edu/content/79/23/5958

Modulation of the extrinsic cell death signaling pathway by viral Flip induces acute-death mediated liver failure – Miriam Bittel, Andreas E. Kremer, Michael Stürzl, Stefan Wirtz, Iris Stolzer, Markus F. Neurath, Gianna Ballon and Claudia Günther. https://www.nature.com/articles/s41419-019-2115-y

CASP9 (caspase 9) is essential for autophagosome maturation through regulation of mitochondrial homeostasis – Hyun-Kyu An, Kyung Min Chung, Hyunhee Park, Jihyun Hong, Ji-Eun Gim, Hyosun Choi, Ye Won Lee, Jieun Choi, Ji Young Mun and Seong-Woon Yu. https://www.tandfonline.com/doi/abs/10.1080/15548627.2019.1695398?journalCode=kaup20

Ptpn6 inhibits caspase-8- and Ripk3/Mlkl-dependent inflammation – Mary Speir, Cameron J. Nowell, Alyce A. Chen, Joanne A. O’Donnell, Isaac S. Shamie, Paul R. Lakin, Akshay A. D’Cruz, Roman O. Braun, Jeff J. Babon, Rowena S. Lewis, Meghan Bliss-Moreau, Inbar Shlomovitz, Shu Wang, Louise H. Cengia, Anca I. Stoica, Razq Hakem, Michelle A. Kelliher, Lorraine A. O’Reilly, Heather Patsiouras, Kate E. Lawlor, Edie Weller, Nathan E. Lewis, Andrew W. Roberts, Motti Gerlic and Ben A. Croker. https://www.nature.com/articles/s41590-019-0550-7

XIAP Interaction with E2F1 and Sp1 via its BIR2 and BIR3 domains specific activated MMP2 to promote bladder cancer invasion – Jiheng Xu, Xiaohui Hua, Rui Yang, Honglei Jin, Jingxia Li, Junlan Zhu, Zhongxian Tian, Maowen Huang, Guosong Jiang, Haishan Huang and Chuanshu Huang. https://www.nature.com/articles/s41389-019-0181-8

Death receptors

Activation of invariant natural killer T cells stimulates adipose tissue remodeling via adipocyte death and birth in obesity – Jeu Park, Jin Young Huh, Jiyoung Oh, Jong In Kim, Sang Mun Han, KyungCheul Shin, Yong Geun Jeon, Sung Sik Choe, Jiyoung Park and Jae Bum Kim. http://genesdev.cshlp.org/content/33/23-24/1657.abstract?etoc

Small molecules that inhibit TNF signalling by stabilising an asymmetric form of the trimer – James O’Connell, John Porter, Boris Kroeplien, Tim Norman, Stephen Rapecki, Rachel Davis, David McMillan, Tracy Arakaki, Alex Burgin, David Fox III, Tom Ceska, Fabien Lecomte, Alison Maloney, Alex Vugler, Bruce Carrington, Benjamin P Cossins, Tim Bourne and Alastair Lawson. https://www.nature.com/articles/s41467-019-13718-w

Disulfide bond-disrupting agents activate the tumor necrosis family-related apoptosis-inducing ligand/death receptor 5 pathway – Mengxiong Wang, Mary E. Law, Bradley J. Davis, Elham Yaaghubi, Amanda F. Ghilardi, Renan B. Ferreira, Chi-Wu Chiang, Olga A. Guryanova, Daniel Kopinke, Coy D. Heldermon, Ronald K. Castellano and Brian K. Law. https://www.nature.com/articles/s41420-019-0228-9

Bcl-2 family proteins

Mcl-1 Interacts with Akt to Promote Lung Cancer Progression – Guo Chen, Dongkyoo Park, Andrew T. Magis, Madhusmita Behera, Suresh S. Ramalingam, Taofeek K. Owonikoko, Gabriel L. Sica, Keqiang Ye, Chao Zhang, Zhengjia Chen, Walter J. Curran and Xingming Deng. https://cancerres.aacrjournals.org/content/79/24/6126

Context-specific regulation of cell survival by a miRNA-controlled BIM rheostat – Verena Labi, Siying Peng, Filippos Klironomos, Mathias Munschauer, Nicolai Kastelic, Tirtha Chakraborty, Katia Schoeler, Emmanuel Derudder, Manuela Martella, Guido Mastrobuoni, Luis R. Hernandez-Miranda, Ines Lahmann, Christine Kocks, Carmen Birchmeier, Stefan Kempa, Leticia Quintanilla-Martinez de Fend, Markus Landthaler, Nikolaus Rajewsky and Klaus Rajewsky. http://genesdev.cshlp.org/content/33/23-24/1673.abstract?etoc

Exploring the potential of BH3 mimetic therapy in squamous cell carcinoma of the head and neck – Rachel J. Carter, Mateus Milani, Michael Butterworth, Ahoud Alotibi, Nicholas Harper, Govindaraju Yedida, Georgia Greaves, Aoula Al-Zebeeby, Andrea L. Jorgensen, Andrew G. Schache, Janet M. Risk, Richard J. Shaw, Terry M. Jones, Joseph J. Sacco, Adam Hurlstone, Gerald M. Cohen and Shankar Varadarajan. https://www.nature.com/articles/s41419-019-2150-8

Side-by-side comparison of BH3-mimetics identifies MCL-1 as a key therapeutic target in AML – Larissa Ewald, Jessica Dittmann, Meike Vogler and Simone Fulda. https://www.nature.com/articles/s41419-019-2156-2

Pyroptosis / Gasdermin D

Bacterial Endotoxin Activates the Coagulation Cascade through Gasdermin D-Dependent Phosphatidylserine Exposure – Xinyu Yang, Xiaoye Cheng, Yiting Tang, Xianhui Qiu, Yupeng Wang, Haixia Kang, Jianfeng Wu, Zhongtai Wang, Yukun Liu, Fangping Chen, Xianzhong Xiao, Nigel Mackman, Timothy R. Billiar, Jiahuai Han, Ben Lu. https://www.cell.com/immunity/fulltext/S1074-7613(19)30463-7

Pyroptosis is a critical inflammatory pathway in the placenta from early onset preeclampsia and in human trophoblasts exposed to hypoxia and endoplasmic reticulum stressors – Shi-Bin Cheng, Akitoshi Nakashima, Warren J. Huber, Sarah Davis, Sayani Banerjee, Zheping Huang, Shigeru Saito, Yoel Sadovsky and Surendra Sharma. https://www.nature.com/articles/s41419-019-2162-4


Radiotherapy and Immunotherapy Promote Tumoral Lipid Oxidation and Ferroptosis via Synergistic Repression of SLC7A11 – Xueting Lang, Michael D. Green, Weimin Wang, Jiali Yu, Jae Eun Choi, Long Jiang, Peng Liao, Jiajia Zhou, Qiang Zhang, Ania Dow, Anjali L. Saripalli, Ilona Kryczek, Shuang Wei, Wojciech Szeliga, Linda Vatan, Everett M. Stone, George Georgiou, Marcin Cieslik, Daniel R. Wahl, Meredith A. Morgan, Arul M. Chinnaiyan, Theodore S. Lawrence and Weiping Zou. https://cancerdiscovery.aacrjournals.org/content/9/12/1673

Prominin2 Drives Ferroptosis Resistance by Stimulating Iron Export – Caitlin W. Brown, John J. Amante, Peter Chhoy, Ameer L. Elaimy, Haibo Liu, Lihua Julie Zhu, Christina E. Baer, Scott J. Dixon, Arthur M. Mercurio. https://www.cell.com/developmental-cell/fulltext/S1534-5807(19)30816-0


Interpreting an apoptotic corpse as anti-inflammatory involves a chloride sensing pathway – Justin S. A. Perry, Sho Morioka, Christopher B. Medina, J. Iker Etchegaray, Brady Barron, Michael H. Raymond, Christopher D. Lucas, Suna Onengut-Gumuscu, Eric Delpire and Kodi S. Ravichandran. https://www.nature.com/articles/s41556-019-0431-1

Dectin-1 Binding to Annexins on Apoptotic Cells Induces Peripheral Immune Tolerance via NADPH Oxidase-2 – Kevin Bode, Fatmire Bujupi, Corinna Link, Tobias Hein, Stephanie Zimmermann, Diluka Peiris, Vincent Jaquet, Bernd Lepenies, Heiko Weyd, Peter H. Krammer. https://www.cell.com/cell-reports/fulltext/S2211-1247(19)31577-3

PLAG enhances macrophage mobility for efferocytosis of apoptotic neutrophils via membrane redistribution of P2Y2 – Guen Tae Kim, Kyu Woong Hahn, Ki‐Young Sohn, Sun Young Yoon, Jae Wha Kim. https://febs.onlinelibrary.wiley.com/doi/abs/10.1111/febs.15135

A role for phagocytosis in inducing cell death during thymocyte negative selection – Nadia S Kurd, Lydia K Lutes, Jaewon Yoon, Shiao Wei Chan, Ivan L Dzhagalov, Ashley R Hoover, Ellen A Robey. https://elifesciences.org/articles/48097


A mitochondrial megachannel resides in monomeric F1FO ATP synthase – Nelli Mnatsakanyan, Marc C. Llaguno, Youshan Yang, Yangyang Yan, Joachim Weber, Fred J. Sigworth and Elizabeth A. Jonas. https://www.nature.com/articles/s41467-019-13766-2

Post-translational Modification of OTULIN Regulates Ubiquitin Dynamics and Cell Death – Todd Douglas, Maya Saleh. https://www.cell.com/cell-reports/fulltext/S2211-1247(19)31485-8


Cannibalism in Breast Cancer: The Dangers of Overeating – Sue Haupt, Simon P. Keam, Ygal Haupt. https://www.cell.com/trends/cancer/fulltext/S2405-8033(19)30201-8

Current translational potential and underlying molecular mechanisms of necroptosis – Tamás Molnár, Anett Mázló, Vera Tslaf, Attila Gábor Szöllősi, Gabriella Emri and Gábor Koncz. https://www.nature.com/articles/s41419-019-2094-z

Ecdysone controlled cell and tissue deletion – Tianqi Xu, Xin Jiang, Donna Denton and Sharad Kumar. https://www.nature.com/articles/s41418-019-0456-9

The DNA-damage response and nuclear events as regulators of nonapoptotic forms of cell death – Evgeniia A. Prokhorova, Aleksandra Yu. Egorshina, Boris Zhivotovsky & Gelina S. Kopeina. https://www.nature.com/articles/s41388-019-0980-6

Comments / other

Prominin-2 Suppresses Ferroptosis Sensitivity – Alexia Belavgeni, Stefan R. Bornstein, Andreas Linkermann. https://www.cell.com/developmental-cell/fulltext/S1534-5807(19)30935-9

Iron expulsion by exosomes drives ferroptosis resistance – Paulina Strzyz. https://www.nature.com/articles/s41580-019-0195-2

Cell death and regeneration in Dresden—the 27th meeting of the European Cell Death Organization – Andreas Linkermann and Dagmar Kulms. https://www.nature.com/articles/s41419-019-2153-5

In conversation with Gerard Evan – Paraminder Dhillon, Gerard Evan. https://febs.onlinelibrary.wiley.com/doi/full/10.1111/febs.15121

ApoList – November 2019

Bcl-2 family proteins

Destabilization of NOXA mRNA as a common resistance mechanism to targeted therapies – Joan Montero, Cécile Gstalder, Daniel J. Kim, Dorota Sadowicz, Wayne Miles, Michael Manos, Justin R. Cidado, J. Paul Secrist, Adriana E. Tron, Keith Flaherty, F. Stephen Hodi, Charles H. Yoon, Anthony Letai, David E. Fisher and Rizwan Haq. https://www.nature.com/articles/s41467-019-12477-y

Targeting melanoma’s MCL1 bias unleashes the apoptotic potential of BRAF and ERK1/2 pathway inhibitors – Matthew J. Sale, Emma Minihane, Noel R. Monks, Rebecca Gilley, Frances M. Richards, Kevin P. Schifferli, Courtney L. Andersen, Emma J. Davies, Mario Aladren Vicente, Eiko Ozono, Aleksandra Markovets, Jonathan R. Dry, Lisa Drew, Vikki Flemington, Theresa Proia, Duncan I. Jodrell, Paul D. Smith and Simon J. Cook. https://www.nature.com/articles/s41467-019-12409-w

Bok regulates mitochondrial fusion and morphology – Jacqualyn J. Schulman, Laura M. Szczesniak, Eric N. Bunker, Heather A. Nelson, Michael W. Roe, Larry E. Wagner II, David I. Yule and Richard J. H. Wojcikiewicz. https://www.nature.com/articles/s41418-019-0327-4

A small molecule protects mitochondrial integrity by inhibiting mTOR activity – Ran Cao, Li Li, Zhengxin Ying, Zichen Cao, Yongfen Ma, Xiaoxu Mao, Jiaojiao Li, Xiangbing Qi, Zhiyuan Zhang and Xiaodong Wang. https://www.pnas.org/content/116/46/23332.abstract

Humanin induces conformational changes in the apoptosis regulator BAX and sequesters it into fibers, preventing mitochondrial outer-membrane permeabilization – Daniel L Morris, David W Kastner, Sabrina Johnson, Marie-Paule Strub, Yi He, Christopher K.E. Bleck, Duck-Yeon Lee and Nico Tjandra. http://www.jbc.org/content/early/2019/11/05/jbc.RA119.011297.abstract

Inhibition of Bcl-2 Synergistically Enhances the Antileukemic Activity of Midostaurin and Gilteritinib in Preclinical Models of FLT3-Mutated Acute Myeloid Leukemia – Jun Ma, Shoujing Zhao, Xinan Qiao, Tristan Knight, Holly Edwards, Lisa Polin, Juiwanna Kushner, Sijana H. Dzinic, Kathryn White, Guan Wang, Lijing Zhao, Hai Lin, Yue Wang, Jeffrey W. Taub and Yubin Ge. https://clincancerres.aacrjournals.org/content/25/22/6815

Death receptors

3D Cellular Architecture Modulates Tyrosine Kinase Activity, Thereby Switching CD95-Mediated Apoptosis to Survival – Gülce S. Gülcüler Balta, Cornelia Monzel, Susanne Kleber, Joel Beaudouin, Emre Balta, Thomas Kaindl, Si Chen, Liang Gao, Meinolf Thiemann, Christian R. Wirtz, Yvonne Samstag, Motomu Tanaka, Ana Martin-Villalba. https://www.cell.com/cell-reports/fulltext/S2211-1247(19)31368-3

TAK1 suppresses RIPK1-dependent cell death and is associated with disease progression in melanoma – Biswajit Podder, Cristiano Guttà, Jan Rožanc, Elke Gerlach, Maria Feoktistova, Diana Panayotova-Dimitrova, Leonidas G. Alexopoulos, Martin Leverkus and Markus Rehm. https://www.nature.com/articles/s41418-019-0315-8

TRAIL-induced variation of cell signaling states provides nonheritable resistance to apoptosis – Baskar R, Fienberg HG, Khair Z, Favaro P, Kimmey S, Green DR, Nolan GP, Plevritis S, Bendall SC. http://www.life-science-alliance.org:/cgi/content/abstract/2/6/e201900554

Targeted enhancement of the therapeutic window of L19-TNF by transient and selective inhibition of RIPK1-signaling cascade – Sheila Dakhel, Tiziano Ongaro, Baptiste Gouyou, Mattia Matasci, Alessandra Villa, Dario Neri  and  Samuele Cazzamalli. http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=view&path[]=27320&path[]=88609

Caspases and IAPs

Activity of caspase-8 determines plasticity between cell death pathways – Kim Newton, Katherine E. Wickliffe, Allie Maltzman, Debra L. Dugger, Rohit Reja, Yue Zhang, Merone Roose-Girma, Zora Modrusan, Meredith S. Sagolla, Joshua D. Webster and Vishva M. Dixit. https://www.nature.com/articles/s41586-019-1752-8

Caspase-8 is the molecular switch for apoptosis, necroptosis and pyroptosis – Melanie Fritsch, Saskia D. Günther, Robin Schwarzer, Marie-Christine Albert, Fabian Schorn, J. Paul Werthenbach, Lars M. Schiffmann, Neil Stair, Hannah Stocks, Jens M. Seeger, Mohamed Lamkanfi, Martin Krönke, Manolis Pasparakis and Hamid Kashkar. https://www.nature.com/articles/s41586-019-1770-6

Sustained Secretion of the Antimicrobial Peptide S100A7 Is Dependent on the Downregulation of Caspase-8 – Tanay Bhatt, Aishwarya Bhosale, Bhavya Bajantri, Mruthyunjaya Swamy Mathapathi, Abrar Rizvi, Giorgio Scita, Amitabha Majumdar, Colin Jamora. https://www.cell.com/cell-reports/fulltext/S2211-1247(19)31412-3

Potent and selective caspase-2 inhibitor prevents MDM-2 cleavage in reversine-treated colon cancer cells – Marcin Poreba, Wioletta Rut, Katarzyna Groborz, Scott J. Snipas, Guy S. Salvesen and Marcin Drag. https://www.nature.com/articles/s41418-019-0329-2

The HtrA3 protease promotes drug‐induced death of lung cancer cells by cleavage of the X‐linked inhibitor of apoptosis protein (XIAP) – Tomasz Wenta, Michal Rychlowski, Ewelina Jurewicz, Miroslaw Jarzab, Dorota Zurawa‐Janicka, Anna Filipek, Barbara Lipinska. https://febs.onlinelibrary.wiley.com/doi/abs/10.1111/febs.14977

Necroptosis and RIPK

RIP1 kinase mediates angiogenesis by modulating macrophages in experimental neovascularization – Takashi Ueta, Kenji Ishihara, Shoji Notomi, Jong-Jer Lee, Daniel E. Maidana, Nikolaos E. Efstathiou, Yusuke Murakami, Eiichi Hasegawa, Kunihiro Azuma, Tetsuya Toyono, Eleftherios I. Paschalis, Makoto Aihara, Joan W. Miller and Demetrios G. Vavvas. https://www.pnas.org/content/116/47/23705.abstract

Efferocytosis, entosis etc

Chemotherapy-induced senescent cancer cells engulf other cells to enhance their survival – Crystal A. Tonnessen-Murray, Wesley D. Frey, Sonia G. Rao, Ashkan Shahbandi, Nathan A. Ungerleider, Joy O. Olayiwola, Lucas B. Murray, Benjamin T. Vinson, Douglas B. Chrisey, Christopher J. Lord and James G. Jackson. http://jcb.rupress.org/content/218/11/3827?etoc

Plexin B2 Is a Regulator of Monocyte Apoptotic Cell Disassembly – Georgia K. Atkin-Smith, Mark A. Miles, Rochelle Tixeira, Fung T. Lay, Mubing Duan, Christine J. Hawkins, Thanh Kha Phan, Stephanie Paone, Suresh Mathivanan, Mark D. Hulett, Weisan Chen, Ivan K.H. Poon. https://www.cell.com/cell-reports/fulltext/S2211-1247(19)31314-2


Defining the role of cytoskeletal components in the formation of apoptopodia and apoptotic bodies during apoptosis – Sarah Caruso, Georgia K. Atkin-Smith, Amy A. Baxter, Rochelle Tixeira, Lanzhou Jiang, Dilara C. Ozkocak, Jascinta P. Santavanond, Mark D. Hulett, Peter Lock, Thanh Kha Phan and Ivan K. H. Poon. https://link.springer.com/article/10.1007/s10495-019-01565-5

Lipid order and charge protect killer T cells from accidental death – Jesse A. Rudd-Schmidt, Adrian W. Hodel, Tahereh Noori, Jamie A. Lopez, Hyun-Jung Cho, Sandra Verschoor, Annette Ciccone, Joseph A. Trapani, Bart W. Hoogenboom and Ilia Voskoboinik. https://www.nature.com/articles/s41467-019-13385-x


MCL1 as a Therapeutic Target in Parkinson’s Disease? – Edward J. Robinson, Sebastian Aguiar, Marten P. Smidt, Lars P. van der Heide. https://www.cell.com/trends/molecular-medicine/fulltext/S1471-4914(19)30232-1

Gasdermins and their role in immunity and inflammation – Pontus Orning, Egil Lien and Katherine A. Fitzgerald. http://jem.rupress.org/content/216/11/2453?etoc


Lipid metabolism offers anticancer treatment by regulating ferroptosis – Michele Carbone and Gerry Melino. https://www.nature.com/articles/s41418-019-0418-2

A powerful cell-protection system prevents cell death by ferroptosis – Brent R. Stockwell. https://www.nature.com/articles/d41586-019-03145-8

ApoList – October 2019

Bcl-2 family proteins

Mitochondrial Reprogramming Underlies Resistance to BCL-2 Inhibition in Lymphoid Malignancies – Romain Guièze, Vivian M. Liu, Daniel Rosebrock, Alexis A. Jourdain, María Hernández-Sánchez, Aina Martinez Zurita, Jing Sun, Elisa Ten Hacken, Kaitlyn Baranowski, Philip A. Thompson, Jin-Mi Heo, Zachary Cartun, Ozan Aygün, J. Bryan Iorgulescu, Wandi Zhang, Giulia Notarangelo, Dimitri Livitz, Shuqiang Li, Matthew S. Davids, Anat Biran, Stacey M. Fernandes, Jennifer R. Brown, Ana Lako, Zoe B. Ciantra, Matthew A. Lawlor, Derin B. Keskin, Namrata D. Udeshi, William G. Wierda, Kenneth J. Livak, Anthony G. Letai, Donna Neuberg, J. Wade Harper, Steven A. Carr, Federica Piccioni, Christopher J. Ott, Ignaty Leshchiner, Cory M. Johannessen, John Doench, Vamsi K. Mootha, Gad Getz, Catherine J. Wu. https://www.cell.com/cancer-cell/fulltext/S1535-6108(19)30373-3

Preferential targeting of MCL-1 by a hydrocarbon-stapled BIM BH3 peptide – Abbas Hadji, Greta K. Schmitt, Mathew R. Schnorenberg, Lauren Roach, Connie M. Hickey, Logan B. Leak, Matthew V. Tirrell and James L. LaBelle. http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=view&path[]=27262&path[]=87960

The transcription factor ETS1 promotes apoptosis resistance of senescent cholangiocytes by epigenetically up-regulating the apoptosis suppressor BCL2L1 – Steven P. O’Hara, Patrick L. Splinter, Christy E. Trussoni, E. Guicciardi, Noah P. Splinter, Mohammed S. Al Suraih, Navine Nasser-Ghodsi, Deborah Stollenwerk, Gregory J. Gores and Nicholas F. LaRusso. http://www.jbc.org/content/early/2019/10/28/jbc.RA119.010176.abstract

Death receptors, caspases and IAPs

Caspase-7 uses RNA to enhance proteolysis of poly(ADP-ribose) polymerase 1 and other RNA-binding proteins – Alexandre Desroches and Jean-Bernard Denault. https://www.pnas.org/content/116/43/21521.abstract?etoc

Interplay between Caspase 9 and X-linked Inhibitor of Apoptosis Protein (XIAP) in the oocyte elimination during fetal mouse development – Xueqing Liu, Veronica Castle and Teruko Taketo. https://www.nature.com/articles/s41419-019-2019-x

Dual Antagonist of cIAP/XIAP ASTX660 Sensitizes HPV− and HPV+ Head and Neck Cancers to TNFα, TRAIL, and Radiation Therapy – Roy Xiao, Yi An, Wenda Ye, Adeeb Derakhshan, Hui Cheng, Xinping Yang, Clint Allen, Zhong Chen, Nicole C. Schmitt and Carter Van Waes. https://clincancerres.aacrjournals.org/content/25/21/6463

Tumor Necrosis Factor Related Apoptosis Inducing Ligand (TRAIL) Regulates Deubiquitinase USP5 In Tumor Cells – Harish Potu, Malathi Kandarpa, Luke F. Peterson, Nicholas J. Donato and Moshe Talpaz. http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=view&path[]=27196&path[]=87593


Pannexin‐1 limits the production of proinflammatory cytokines during necroptosis – Tiphaine Douanne, Gwennan André‐Grégoire, Kilian Trillet, An Thys, Antonin Papin, Magalie Feyeux, Philippe Hulin, David Chiron, Julie Gavard, Nicolas Bidère. https://www.embopress.org/doi/abs/10.15252/embr.201947840


FSP1 is a glutathione-independent ferroptosis suppressor – Sebastian Doll, Florencio Porto Freitas, Ron Shah, Maceler Aldrovandi, Milene Costa da Silva, Irina Ingold, Andrea Goya Grocin, Thamara Nishida Xavier da Silva, Elena Panzilius, Christina Scheel, André Mourão, Katalin Buday, Mami Sato, Jonas Wanninger, Thibaut Vignane, Vaishnavi Mohana, Markus Rehberg, Andrew Flatley, Aloys Schepers, Andreas Kurz, Daniel White, Markus Sauer, Michael Sattler, Edward William Tate, Werner Schmitz, Almut Schulze, Valerie O’Donnel, Bettina Proneth, Grzegorz M. Popowicz, Derek Pratt, José Pedro Friedmann Angeli and Marcus Conrad. https://www.nature.com/articles/s41586-019-1707-0

The CoQ oxidoreductase FSP1 acts parallel to GPX4 to inhibit ferroptosis – Kirill Bersuker, Joseph Hendricks, Zhipeng Li, Leslie Magtanong, Breanna Ford, Peter H. Tang, Melissa A. Roberts, Bingqi Tong, Thomas J. Maimone, Roberto Zoncu, Michael C. Bassik, Daniel K. Nomura, Scott J. Dixon and James A. Olzmann. https://www.nature.com/articles/s41586-019-1705-2

Exquisite sensitivity of adrenocortical carcinomas to induction of ferroptosis – Alexia Belavgeni, Stefan R. Bornstein, Anne von Mässenhausen, Wulf Tonnus, Julian Stumpf, Claudia Meyer, Evelyn Othmar, Markus Latk, Waldemar Kanczkowski, Matthias Kroiss, Constanze Hantel, Christian Hugo, Martin Fassnacht, Christian G. Ziegler, Andrew V. Schally, Nils P. Krone and Andreas Linkermann. https://www.pnas.org/content/116/44/22269.abstract?etoc

Ischemia-induced ACSL4 activation contributes to ferroptosis-mediated tissue injury in intestinal ischemia/reperfusion – Yang Li, Dongcheng Feng, Zhanyu Wang, Yan Zhao, Ruimin Sun, Donghai Tian, Deshun Liu, Feng Zhang, Shili Ning, Jihong Yao and Xiaofeng Tian. https://www.nature.com/articles/s41418-019-0299-4

Stearoyl-CoA Desaturase 1 Protects Ovarian Cancer Cells from Ferroptotic Cell Death – Lia Tesfay, Bibbin T. Paul, Anna Konstorum, Zhiyong Deng, Anderson O. Cox, Jingyun Lee, Cristina M. Furdui, Poornima Hegde, Frank M. Torti and Suzy V. Torti. https://cancerres.aacrjournals.org/content/79/20/5355

The oncometabolite 2-hydroxyglutarate produced by mutant IDH1 sensitizes cells to ferroptosis – Tian-Xiang Wang, Jun-Yun Liang, Cheng Zhang, Yue Xiong, Kun-Liang Guan and Hai-Xin Yuan. https://www.nature.com/articles/s41419-019-1984-4


Resolution metabolomes activated by hypoxic environment – Paul C. Norris, Stephania Libreros and Charles N. Serhan. https://advances.sciencemag.org/content/5/10/eaax4895

Phosphatidylserine on viable sperm and phagocytic machinery in oocytes regulate mammalian fertilization – Claudia M. Rival, Wenhao Xu, Laura S. Shankman, Sho Morioka, Sanja Arandjelovic, Chang Sup Lee, Karen M. Wheeler, Ryan P. Smith, Lisa B. Haney, Brant E. Isakson, Scott Purcell, Jeffrey J. Lysiak and Kodi S. Ravichandran. https://www.nature.com/articles/s41467-019-12406-z

Phagoptosis, entosis etc

Gulp1 controls Eph/ephrin trogocytosis and is important for cell rearrangements during development – Jingyi Gong, Thomas N. Gaitanos, Olivia Luu, Yunyun Huang, Louise Gaitanos, Jana Lindner, Rudolf Winklbauer and Rüdiger Klein. http://jcb.rupress.org/content/218/10/3455?etoc

Chemotherapy-induced senescent cancer cells engulf other cells to enhance their survival – Crystal A. Tonnessen-Murray, Wesley D. Frey, Sonia G. Rao, Ashkan Shahbandi, Nathan A. Ungerleider, Joy O. Olayiwola, Lucas B. Murray, Benjamin T. Vinson, Douglas B. Chrisey, Christopher J. Lord, James G. Jackson. http://jcb.rupress.org/content/early/2019/09/16/jcb.201904051

Natural killers

Extracellular NK histones promote immune cell anti-tumor activity by inducing cell clusters through binding to CD138 receptor – Beatriz Martín-Antonio, G. Suñe, A. Najjar, L. Perez-Amill, A. Antoñana-Vildosola, M. Castella, S. León, M. Velasco-de Andrés, F. Lozano, E. Lozano, C. Bueno, J. M. Estanyol, C. Muñoz-Pinedo, S. N. Robinson and A. Urbano-Ispizua. https://jitc.biomedcentral.com/articles/10.1186/s40425-019-0739-1

The Mechanism of Anti–PD-L1 Antibody Efficacy against PD-L1–Negative Tumors Identifies NK Cells Expressing PD-L1 as a Cytolytic Effector – Wenjuan Dong, Xiaojin Wu, Shoubao Ma, Yufeng Wang, Ansel P. Nalin, Zheng Zhu, Jianying Zhang, Don M. Benson, Kai He, Michael A. Caligiuri and Jianhua Yu. https://cancerdiscovery.aacrjournals.org/content/9/10/1422


Serine-47 phosphorylation of cytochrome c in the mammalian brain regulates cytochrome c oxidase and caspase-3 activity – Hasini A. Kalpage, Asmita Vaishnav, Jenney Liu, Ashwathy Varughese, Junmei Wan, Alice A. Turner, Qinqin Ji, Matthew P. Zurek, Alexandr A. Kapralov, Valerian E. Kagan, Joseph S. Brunzelle, Maurice-Andre Recanati, Lawrence I. Grossman, Thomas H. Sanderson, Icksoo Lee, Arthur R. Salomon, Brian F. P. Edwards and Maik Hüttemann. https://www.fasebj.org/doi/abs/10.1096/fj.201901120R

Residual apoptotic activity of a tumorigenic p53 mutant improves cancer therapy responses – Oleg Timofeev, Boris Klimovich, Jean Schneikert, Michael Wanzel, Evangelos Pavlakis, Julia Noll, Samet Mutlu, Sabrina Elmshäuser, Andrea Nist, Marco Mernberger, Boris Lamp, Ulrich Wenig, Alexander Brobeil, Stefan Gattenlöhner, Kernt Köhler, Thorsten Stiewe. https://www.embopress.org/doi/full/10.15252/embj.2019102096

Mitochondrial NIX Promotes Tumor Survival in the Hypoxic Niche of Glioblastoma – Jinkyu Jung, Ying Zhang, Orieta Celiku, Wei Zhang, Hua Song, Brian J. Williams, Amber J. Giles, Jeremy N. Rich, Roger Abounader, Mark R. Gilbert and Deric M. Park. https://cancerres.aacrjournals.org/content/79/20/5218

Cell Competition Is Driven by Autophagy – Rina Nagata, Mai Nakamura, Yuya Sanaki, Tatsushi Igaki. https://www.cell.com/developmental-cell/fulltext/S1534-5807(19)30701-4


The Diversification of Cell Death and Immunity: Memento Mori – Arnaud J. Legrand, Maria Konstantinou, Emily F. Goode, Pascal Meier. https://www.cell.com/molecular-cell/fulltext/S1097-2765(19)30691-4

Perspective: The Incomplete Puzzle of the BCL2 Proteins – Hector Flores-Romero and Ana J. García-Sáez. https://www.mdpi.com/2073-4409/8/10/1176


Senescent cells feed on their neighbours – Michael Overholtzer. https://www.nature.com/articles/d41586-019-03271-3

A powerful cell-protection system prevents cell death by ferroptosis – Brent R. Stockwell. https://www.nature.com/articles/d41586-019-03145-8

p53 defies convention again: a p53 mutant that has lost tumor suppression but still can kill – James J Manfredi. https://www.embopress.org/doi/abs/10.15252/embj.2019103322

Stearoyl CoA Desaturase Regulates Ferroptosis in Ovarian Cancer Offering New Therapeutic Perspectives – Michele Carbone and Gerry Melino. https://cancerres.aacrjournals.org/content/79/20/5149

Cell Competition Triggers Suicide by Autophagy – Caroline Dillard, Tor Erik Rusten. https://www.cell.com/developmental-cell/fulltext/S1534-5807(19)30770-1

Eph receptors and ephrins engage in cellular cannibalism – Elena B. Pasquale. http://jcb.rupress.org/content/218/10/3168?etoc

Apoptotic Caspases: A Double-Edged Sword in Radiation-Induced Immunogenicity – Mara De Martino, Claire Vanpouille-Box. https://www.cell.com/trends/cell-biology/fulltext/S0962-8924(19)30159-X