ApoList – December 2022


Bcl-2 family proteins


BCL-xL inhibition potentiates cancer therapies by redirecting the outcome of p53 activation from senescence to apoptosis – Vijaya Bharti, Reese Watkins, Amrendra Kumar, Rebecca L. Shattuck-Brandt, Alexis Mossing, Arjun Mittra, Chengli Shen, Allan Tsung, Alexander E. Davies, Walter Hanel, John C. Reneau, Catherine Chung, Gina M. Sizemore, Ann Richmond, Vivian L. Weiss, Anna E. Vilgelm. https://www.cell.com/cell-reports/fulltext/S2211-1247(22)01718-1

SRSF6 balances mitochondrial-driven innate immune outcomes through alternative splicing of BAX – Allison R Wagner, Chi G Weindel, Kelsi O West, Haley M Scott, Robert O Watson, Kristin L Patrick. https://elifesciences.org/articles/82244

Endoplasmic reticulum protein BIK binds to and inhibits mitochondria-localized anti-apoptotic proteins – Elizabeth J. Osterlund, Nehad Hirmiz, Dang Nguyen, James M. Pemberton, Qiyin Fang, David W. Andrews. https://www.jbc.org/article/S0021-9258(22)01306-0/fulltext

Lisaftoclax (APG-2575) Is a Novel BCL-2 Inhibitor with Robust Antitumor Activity in Preclinical Models of Hematologic Malignancy – Jing Deng, Aneel Paulus, Douglas D. Fang, Alak Manna, Guangfeng Wang, Hengbang Wang, Saijie Zhu, Jianyong Chen, Ping Min, Yan Yin, Navnita Dutta, Nabanita Halder, Gina Ciccio, [..] Asher Chanan-Khan, Yifan Zhai. https://aacrjournals.org/clincancerres/article-abstract/28/24/5455/711449

Targeting anti-apoptotic pathways eliminates senescent melanocytes and leads to nevi regression – Jaskaren Kohli, Chen Ge, Eleni Fitsiou, Miriam Doepner, Simone M. Brandenburg, William J. Faller, Todd W. Ridky and Marco Demaria. https://www.nature.com/articles/s41467-022-35657-9


Death receptors


TRAIL receptors promote constitutive and inducible IL-8 secretion in non-small cell lung carcinoma – Francesca Favaro, Fedra Luciano-Mateo, Joaquim Moreno-Caceres, Miguel Hernández-Madrigal, Demi Both, Chiara Montironi, Franziska Püschel, Ernest Nadal, Eric Eldering and Cristina Muñoz-Pinedo. https://www.nature.com/articles/s41419-022-05495-0

ATG9A prevents TNF cytotoxicity by an unconventional lysosomal targeting pathway – Jon Huyghe, Dario Priem, Lisette Van Hove, Barbara Gilbert, Jürgen Fritsch, Yasuo Uchiyama, Esther Hoste, Geert van Loo, Mathieu J. M. Bertrand. https://www.science.org/doi/abs/10.1126/science.add6967

Neutrophils and macrophages drive TNF-induced lethality via TRIF/CD14-mediated responses – Hayley I. Muendlein, Wilson M. Connolly, James Cameron, David Jetton, Zoie Magri, Irina Smirnova, Edouard Vannier, Xudong Li, Amanda J. Martinot, Rebecca Batorsky, Alexander Poltorak. https://www.science.org/doi/abs/10.1126/sciimmunol.add0665


Caspases


Caspase-8 is required for HSV-1-induced apoptosis and promotes effective viral particle release via autophagy inhibition – Francesca Marino-Merlo, Anusha Klett, Emanuela Papaianni, Selene Francesca Anna Drago, Beatrice Macchi, María Gabriela Rincón, Federica Andreola, Annalucia Serafino, Sandro Grelli, Antonio Mastino and Christoph Borner. https://www.nature.com/articles/s41418-022-01084-y

Blocking Caspase-1/Gsdmd and Caspase-3/-8/Gsdme pyroptotic pathways rescues silicosis in mice – Lulu Kang, Jinghong Dai, Yufang Wang, Peiliang Shi, Yujie Zou, Jingwen Pei, Yaqiong Tian, Ji Zhang, Visarut Codey Buranasudja, Jingyu Chen, Hourong Cai, Xiang Gao, Zhaoyu Lin. https://journals.plos.org/plosgenetics/article?id=10.137


Pyroptosis


Gasdermins and pannexin-1 mediate pathways of chemotherapy-induced cell lysis in hematopoietic malignancies – Bowen Zhou, Christopher B. Ryder, George R. Dubyak, Derek W. Abbott. https://www.science.org/doi/abs/10.1126/scisignal.abl6781

Spatiotemporal control of necroptotic cell death and plasma membrane recruitment using engineered MLKL domains – Amir Taslimi, Kaiah M. Fields, Kristin D. Dahl, Qi Liu and Chandra L. Tucker. https://www.nature.com/articles/s41420-022-01258-0


Miscellanous


Inhibition of Glucose Uptake Blocks Proliferation but Not Cytotoxic Activity of NK Cells – Lea Katharina Picard, Elisabeth Littwitz-Salomon, Herbert Waldmann, Carsten Watzl. https://www.mdpi.com/2073-4409/11/21/3489

Myeloid cell-derived proteases produce a proinflammatory form of IL-37 that signals via IL-36 receptor engagement – Graeme P. Sullivan, Pavel Davidovich, Natalia Muñoz-Wolf, Ross W. Ward, Yasmina E. Hernandez Santana,5, Danielle M. Clancy, Aoife Gorman, Zaneta Najda, Boris Turk6, Patrick T. Walsh, Ed C. Lavelle, Seamus J. Martin. https://www.science.org/doi/abs/10.1126/sciimmunol.ade5728

Mitochondrial genome recovery by ATFS-1 is essential for development after starvation – Nandhitha Uma Naresh, Sookyung Kim, Tomer Shpilka, Qiyuan Yang, Yunguang Du, Cole M. Haynes. https://www.cell.com/cell-reports/fulltext/S2211-1247(22)01771-5

[maybe also post-MOMP?!]


Reviews / Comments


Pore-forming proteins as drivers of membrane permeabilization in cell death pathways – Peter Vandenabeele, Geert Bultynck and Savvas N. Savvides. https://www.nature.com/articles/s41580-022-00564-w

The path to venetoclax resistance is paved with mutations, metabolism, and more – Graeme P. Sullivan, Lyndsey Flanagan, Daniel Alencar Rodrigues, Tríona Ní Chonghaile. https://www.science.org/doi/abs/10.1126/scitranslmed.abo6891

mTORC1 beyond anabolic metabolism: Regulation of cell death – Jiajun Zhu, Hua Wang, Xuejun Jiang. https://rupress.org/jcb/article/221/12/e202208103/213609

Surviving death: emerging concepts of RIPK3 and MLKL ubiquitination in the regulation of necroptosis – Rebekka Karlowitz, Sjoerd J. L. van Wijk. https://febs.onlinelibrary.wiley.com/doi/full/10.1111/febs.16255

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