Bcl-2 family proteins
Sublethal cytochrome c release generates drug-tolerant persister cells – Halime Kalkavan, Mark J. Chen, Jeremy C. Crawford, Giovanni Quarato, Patrick Fitzgerald, Stephen W.G. Tait, Colin R. Goding, Douglas R. Green. https://www.cell.com/cell/fulltext/S0092-8674(22)00978-3
Apoptotic priming is defined by the dynamic exchange of Bcl-2 proteins between mitochondria and cytosol – Louise E. King, Ricardo Rodriguez-Enriquez, Robert Pedley, Charlotte E. L. Mellor, Pengbo Wang, Egor Zindy, Michael R. H. White, Keith Brennan and Andrew P. Gilmore. https://www.nature.com/articles/s41418-022-01013-z
Alternative splicing of apoptosis genes promotes human T cell survival – Davia Blake, Caleb M Radens, Max B Ferretti, Matthew R Gazzara, Kristen W Lynch. https://elifesciences.org/articles/80953
BOK controls ER proteostasis and physiological ER stress responses in neurons – Franziska Walter, Beatrice D’Orsi, Anagha Jagannathan, Heiko Dussmann and Jochen H. M. Prehn. https://www.frontiersin.org/articles/10.3389/fcell.2022.915065/full
MCL-1 is a master regulator of cancer dependency on fatty acid oxidation – Michelle S. Prew, Utsarga Adhikary, Dong Wook Choi, Erika P. Portero, Joao A. Paulo, Pruthvi Gowda, Amit Budhraja, Joseph T. Opferman, Steven P. Gygi, Nika N. Danial, Loren D. Walensky. https://www.cell.com/cell-reports/fulltext/S2211-1247(22)01286-4
Decoding the concealed transcriptional signature of the apoptosis-related BCL2 antagonist/killer 1 (BAK1) gene in human malignancies – Konstantina Athanasopoulou, Panagiotis G. Adamopoulos, Glykeria N. Daneva and Andreas Scorilas. https://link.springer.com/article/10.1007/s10495-022-01753-w
c-Myc plays a critical role in the antileukemic activity of the Mcl-1-selective inhibitor AZD5991 in acute myeloid leukemia – Shuang Liu, Xinan Qiao, Shuangshuang Wu, Yuqinq Gai, Yongwei Su, Holly Edwards, Yue Wang, Hai Lin, Jeffrey W. Taub, Guan Wang, Yubin Ge. https://link.springer.com/article/10.1007/s10495-022-01756-7
A novel BH3 mimetic Bcl-2 inhibitor promotes autophagic cell death and reduces in vivo Glioblastoma tumor growth – Seyma Calis, Berna Dogan, Serdar Durdagi, Asuman Celebi, Ozlem Yapicier, Turker Kilic, Eda Tahir Turanli and Timucin Avsar, https://www.nature.com/articles/s41420-022-01225-9
Splicing factor BUD31 promotes ovarian cancer progression through sustaining the expression of anti-apoptotic BCL2L12 – Zixiang Wang, Shourong Wang, Junchao Qin, Xiyu Zhang, Gang Lu, Hongbin Liu, Haiyang Guo, Ligang Wu, Victoria O. Shender, Changshun Shao, Beihua Kong and Zhaojian Liu. https://www.nature.com/articles/s41467-022-34042-w
Death receptors
Limiting glutamine utilization activates a GCN2/TRAIL-R2/Caspase-8 apoptotic pathway in glutamine-addicted tumor cells – Rosario Yerbes, Rocío Mora-Molina, F. Javier Fernández-Farrán, Laura Hiraldo, Abelardo López-Rivas and Carmen Palacios. https://www.nature.com/articles/s41419-022-05346-y
MMP7 cleavage of amino-terminal CD95 death receptor switches signaling toward non-apoptotic pathways – Shoji F. Kenji, Keerthi Kurma, Brigitte Collet, Christelle Oblet, Laure Debure, Carmelo Di Primo, Laëtitia Minder, Franck Vérité, Yannic Danger, Mickael Jean, Aubin Penna, Nicolas Levoin and Patrick Legembre. https://www.nature.com/articles/s41419-022-05352-0
Phase I trial of the TNF-α inhibitor certolizumab plus chemotherapy in stage IV lung adenocarcinomas – Paul K. Paik, Jia Luo, Ni Ai, Rachel Kim, Linda Ahn, Anup Biswas, Courtney Coker, Wanchao Ma, Phillip Wong, Darren J. Buonocore, W. Victoria Lai, Jamie E. Chaft, Swarnali Acharyya, Joan Massagué and Mark G. Kris. https://www.nature.com/articles/s41467-022-33719-6
Escaping cell death via TRAIL decoy receptors: a systematic review of their roles and expressions in colorectal cancer – Kelly Xue Jing Jong, Elsa Haniffah Mejia Mohamed and Zaridatul Aini Ibrahim. https://link.springer.com/article/10.1007/s10495-022-01774-5
Caspases
PIDDosome-SCAP crosstalk controls high-fructose-diet-dependent transition from simple steatosis to steatohepatitis – Ju Youn Kim, Lily Q. Wang, Valentina C. Sladky, Tae Gyu Oh, Junlai Liu, Kaitlyn Trinh, Felix Eichin, Michael Downes, Mojgan Hosseini, Etienne D. Jacotot, Ronald M. Evans, Andreas Villunger, Michael Karin. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(22)00348-5
Molecular mechanism of RIPK1 and caspase-8 in homeostatic type I interferon production and regulation – Yaqiu Wang, Rajendra Karki, Raghvendra Mall, Bhesh Raj Sharma, Ravi C. Kalathur, SangJoon Lee, Balabhaskararao Kancharana, Matthew So, Katie L. Combs, Thirumala-Devi Kanneganti. https://www.cell.com/cell-reports/fulltext/S2211-1247(22)01275-X
Necroptosis
Caspase-8 and FADD prevent spontaneous ZBP1 expression and necroptosis – Diego A. Rodriguez, Giovanni Quarato, Swantje Liedmann, Bart Tummers, Ting Zhang, Cliff Guy, Jeremy Chase Crawford, Gustavo Palacios, Stephane Pelletier, Halime Kalkavan, Jeremy J. P. Shaw, Patrick Fitzgerald, Mark J. Chen, Siddharth Balachandran and Douglas R. Green. https://www.pnas.org/doi/10.1073/pnas.2207240119
Human ZBP1 induces cell death-independent inflammatory signaling via RIPK3 and RIPK1 – Ruoshi Peng, Chris Kedong Wang, Xuan Wang-Kan, Manja Idorn, Majken Kjær, Felix Y Zhou, Berthe Katrine Fiil, Frederik Timmermann, Susana L Orozco, Julia McCarthy, Carol S Leung, Xin Lu, Katrin Bagola, Jan Rehwinkel, Andrew Oberst, Jonathan Maelfait, Søren R Paludan, Mads Gyrd-Hansen. https://www.embopress.org/doi/full/10.15252/embr.202255839
Pyroptosis
GSDMD drives canonical inflammasome‐induced neutrophil pyroptosis and is dispensable for NETosis – Dhruv Chauhan, Dieter Demon, Lieselotte Vande Walle, Oonagh Paerewijck, Annalisa Zecchin, Leslie Bosseler, Karin Santoni, Rémi Planès, Silvia Ribo, Amelie Fossoul, Amanda Gonçalves, Hanne Van Gorp, Nina Van Opdenbosch, Filip Van Hauwermeiren, Etienne Meunier, Andy Wullaert, Mohamed Lamkanfi. https://www.embopress.org/doi/abs/10.15252/embr.202154277
Gasdermin D restricts anti-tumor immunity during PD-L1 checkpoint blockade – Yuying Jiang, Yongbing Yang, Yingchao Hu, Rui Yang, Jiajia Huang, Yi Liu, Yuqing Wu, Sheng Li, Chunmei Ma, Fiachra Humphries, Bingwei Wang, Xi Wang, Zhibin Hu, Shuo Yang. https://www.cell.com/cell-reports/fulltext/S2211-1247(22)01409-7
GSDME deficiency leads to the aggravation of UVB-induced skin inflammation through enhancing recruitment and activation of neutrophils – Yujie Chen, Ni Lian, Sihan Chen, Ta Xiao, Yangying Ke, Yiqun Zhang, Changjun Song, Yong Yang, Song Xu, Heng Gu and Xu Chen. https://www.nature.com/articles/s41419-022-05276-9
Enhancing Gasdermin-induced tumor pyroptosis through preventing ESCRT-dependent cell membrane repair augments antitumor immune response – Zhaoting Li, Fanyi Mo, Yixin Wang, Wen Li, Yu Chen, Jun Liu, Ting-Jing Chen-Mayfield and Quanyin Hu. https://www.nature.com/articles/s41467-022-34036-8
Ferroptosis
Selective ferroptosis vulnerability due to familial Alzheimer’s disease presenilin mutations – Mark A. Greenough, Darius J. R. Lane, Rachelle Balez, Helena Targa Dias Anastacio, Zhiwen Zeng, Katherine Ganio, Christopher A. McDevitt, Karla Acevedo, Abdel Ali Belaidi, Jari Koistinaho, Lezanne Ooi, Scott Ayton and Ashley I. Bush. https://www.nature.com/articles/s41418-022-01003-1
Doxorubicin causes ferroptosis and cardiotoxicity by intercalating into mitochondrial DNA and disrupting Alas1-dependent heme synthesis – Ko Abe, Masataka Ikeda, Tomomi Ide, Tomonori Tadokoro, Hiroko Deguchi Miyamoto, Shun Furusawa, Yoshitomo Tsutsui, Ryo Miyake, Kosei Ishimaru, Masatsugu Watanabe, Shouji Matsushima, Tomoko Koumura, Ken-ichi Yamada, Hirotaka Imai, Hiroyuki Tsutsui. https://www.science.org/doi/abs/10.1126/scisignal.abn8017
Efferocytosis, entosis, phagoptosis etc
Mobilizing phospholipids on tumor plasma membrane implicates phosphatidylserine externalization blockade for cancer immunotherapy – Weihong Wang, Shaoxian Wu, Zhanpeng Cen, Yixin Zhang, Yuang Chen, Yixian Huang, Anthony R. Cillo, Joshua S. Prokopec, Giovanni Quarato, Dario A.A. Vignali, Jacob Stewart-Ornstein, Song Li, Binfeng Lu, Yi-Nan Gong. https://www.cell.com/cell-reports/fulltext/S2211-1247(22)01447-4
Non-autonomous cell death induced by the Draper phagocytosis receptor requires signaling through the JNK and SRC pathways – Sandy B. Serizier; Jeanne S. Peterson; Kimberly McCall. https://journals.biologists.com/jcs/article-abstract/135/20/jcs250134/278232
Reviews
Understanding MCL1: from cellular function and regulation to pharmacological inhibition – Mónica Sancho, Diego Leiva, Estefanía Lucendo, Mar Orzáez. https://febs.onlinelibrary.wiley.com/doi/full/10.1111/febs.16136
Dying in self-defence: a comparative overview of immunogenic cell death signalling in animals and plants – Takaki Maekawa, Hamid Kashkar and Núria S. Coll. https://www.nature.com/articles/s41418-022-01060-6
Stressed to death: Mitochondrial stress responses connect respiration and apoptosis in cancer – Jacob M. Winter, Tarun Yadav, Jared Rutter. https://www.cell.com/molecular-cell/fulltext/S1097-2765(22)00708-0
What role does pyroptosis play in cancer? – Chen Huang, Jian Li, Chenliang Zhang. https://www.sciencedirect.com/science/article/pii/S2212877822001569
Comments
Cap CASP, not SCAP, to fight steatohepatitis – Wolfram Goessling. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(22)00404-1
Vitamin K: A new guardian against ferroptosis – Tal Hirschhorn, Brent R. Stockwell. https://www.cell.com/molecular-cell/fulltext/S1097-2765(22)00958-3
Persisting through apoptosis – Michael Attwaters. https://www.nature.com/articles/s41580-022-00544-0
Apoptosis and cell death 