ApoList – September 2019

Death receptors

NK cells switch from granzyme B to death receptor–mediated cytotoxicity during serial killing – Isabel Prager, Clarissa Liesche, Hanna van Ooijen, Doris Urlaub, Quentin Verron, Niklas Sandström, Frank Fasbender,  Maren Claus, Roland Eils, Joël Beaudouin, Björn Önfelt, Carsten Watzl. http://jem.rupress.org/content/216/9/2113?etoc

TNFR2 induced priming of the inflammasome leads to a RIPK1-dependent cell death in the absence of XIAP – Janin Knop, Lisanne M. Spilgies, Stefanie Rufli, Ramona Reinhart, Lazaros Vasilikos, Monica Yabal, Erika Crowley, Philipp J. Jost, Rebecca A. Marsh, Harald Wajant, Mark D. Robinson, Thomas Kaufmann and W. Wei-Lynn Wong. https://www.nature.com/articles/s41419-019-1938-x

A20 protects cells from TNF-induced apoptosis through linear ubiquitin-dependent and -independent mechanisms – Dario Priem, Michael Devos, Sarah Druwé, Arne Martens, Karolina Slowicka, Adrian T. Ting, Manolis Pasparakis, Wim Declerq, Peter Vandenabeele, Geert van Loo and Mathieu J. M. Bertrand. https://www.nature.com/articles/s41419-019-1937-y

The volatile anesthetic sevoflurane reduces neutrophil apoptosis via Fas death domain–Fas-associated death domain interaction – Sophia Koutsogiannaki, Lifei Hou, Hasan Babazada, Toshiaki Okuno, Nathan Blazon-Brown, Sulpicio G. Soriano, Takehiko Yokomizo and Koichi Yuki. https://www.fasebj.org/doi/abs/10.1096/fj.201901360R?ai=ts&ui=ly8&af=T

Heterogeneous responses to low level death receptor activation are explained by random molecular assembly of the Caspase-8 activation platform – Matveeva A, Fichtner M, McAllister K, McCann C, Sturrock M, Longley DB, Prehn JHM. https://www.ncbi.nlm.nih.gov/pubmed/31553717


Cleavage of RIPK1 by caspase-8 is crucial for limiting apoptosis and necroptosis – Kim Newton, Katherine E. Wickliffe, Debra L. Dugger, Allie Maltzman, Merone Roose-Girma, Monika Dohse, László Kőműves, Joshua D. Webster and Vishva M. Dixit. https://www.nature.com/articles/s41586-019-1548-x

Caspase-10 inhibits ATP-citrate lyase-mediated metabolic and epigenetic reprogramming to suppress tumorigenesis – Rajni Kumari, Ruhi S. Deshmukh and Sanjeev Das. https://www.nature.com/articles/s41467-019-12194-6

Salvador–Warts–Hippo pathway regulates sensory organ development via caspase-dependent nonapoptotic signaling – Lan-Hsin Wang and Nicholas E. Baker. https://www.nature.com/articles/s41419-019-1924-3


Viral MLKL Homologs Subvert Necroptotic Cell Death by Sequestering Cellular RIPK3 – Emma J. Petrie, Jarrod J. Sandow, Wil I.L. Lehmann, Lung-Yu Liang, Diane Coursier, Samuel N. Young, Wilhelmus J.A. Kersten, Cheree Fitzgibbon, André L. Samson, Annette V. Jacobsen, Kym N. Lowes, Amanda E. Au, Hélène Jousset Sabroux, Najoua Lalaoui, Andrew I. Webb, Guillaume Lessene, Gerard Manning, Isabelle S. Lucet, James M. Murphy. https://www.cell.com/cell-reports/fulltext/S2211-1247(19)31103-9

TAK1 regulates endothelial cell necroptosis and tumor metastasis – Lida Yang, Sayali Joseph, Tianliang Sun, Julia Hoffmann, Sophia Thevissen, Stefan Offermanns and Boris Strilic. https://www.nature.com/articles/s41418-018-0271-8

Cell cycle arrest in mitosis promotes interferon-induced necroptosis – Tanja Frank, Marcel Tuppi, Manuela Hugle, Volker Dötsch, Sjoerd J. L. van Wijk and Simone Fulda. https://www.nature.com/articles/s41418-019-0298-5

The bromodomain protein BRD4 positively regulates necroptosis via modulating MLKL expression – Yu Xiong, Linli Li, Liting Zhang, Yangyang Cui, Chengyong Wu, Hui Li, Kai Chen, Qiuyuan Yang, Rong Xiang, Yiguo Hu, Shile Huang, Yuquan Wei and Shengyong Yang. https://www.nature.com/articles/s41418-018-0262-9

Ubiquitination of RIPK1 suppresses programmed cell death by regulating RIPK1 kinase activation during embryogenesis – Xixi Zhang, Haiwei Zhang, Chengxian Xu, Xiaoming Li, Ming Li, Xiaoxia Wu, Wenjuan Pu, Bin Zhou, Haikun Wang, Dali Li, Qiurong Ding, Hao Ying, Hui Wang and Haibing Zhang. https://www.nature.com/articles/s41467-019-11839-w

K63-linked ubiquitination regulates RIPK1 kinase activity to prevent cell death during embryogenesis and inflammation – Yong Tang, Hailin Tu, Jie Zhang, Xueqiang Zhao, Yini Wang, Jun Qin and Xin Lin. https://www.nature.com/articles/s41467-019-12033-8

Bcl-2 family proteins

Mitochondrial translocation of cyclin C stimulates intrinsic apoptosis through Bax recruitment – Jan Jezek, Kai‐Ti Chang, Amogh M Joshi, Randy Strich. https://www.embopress.org/doi/10.15252/embr.201847425

Therapeutic inhibition of Mcl-1 blocks cell survival in estrogen receptor-positive breast cancers – Michelle M. Williams, David L. Elion, Bushra Rahman, Donna J. Hicks, Violeta Sanchez and Rebecca S. Cook. http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=view&path[]=27070&path[]=87031


A genome‐wide screen identifies IRF2 as a key regulator of caspase‐4 in human cells – Sacha Benaoudia, Amandine Martin, Marta Puig Gamez, Gabrielle Gay, Brice Lagrange, Maxence Cornut, Kyrylo Krasnykov, Jean‐Baptiste Claude, Cyril F Bourgeois, Sandrine Hughes, Benjamin Gillet, Omran Allatif, Antoine Corbin, Romeo Ricci, Thomas Henry. https://www.embopress.org/doi/10.15252/embr.201948235


The Hippo Pathway Effector TAZ Regulates Ferroptosis in Renal Cell Carcinoma – Wen-Hsuan Yang, Chien-Kuang Cornelia Ding, Tianai Sun, Gabrielle Rupprecht, Chao-Chieh Lin, David Hsu, Jen-Tsan Chi. https://www.cell.com/cell-reports/fulltext/S2211-1247(19)31023-X


Migratory Neural Crest Cells Phagocytose Dead Cells in the Developing Nervous System – Yunlu Zhu, Samantha C. Crowley, Andrew J. Latimer, Gwendolyn M. Lewis, Rebecca Nash, Sarah Kucenas. https://www.cell.com/cell/fulltext/S0092-8674(19)30889-X

Sensing of apoptotic cells through Axl causes lung basal cell proliferation in inflammatory diseases – Naoya Fujino, Oliver J. Brand, David J. Morgan, Toshifumi Fujimori, Aleksander M. Grabiec, Christopher P. Jagger, Rose A. Maciewicz, Mitsuhiro Yamada, Koji Itakura, Hisatoshi Sugiura, Masakazu Ichinose, Tracy Hussell. http://jem.rupress.org/content/216/9/2184?etoc


Single-Cell and Population-Level Analyses Using Real-Time Kinetic Labeling Couples Proliferation and Cell Death Mechanisms – Jesse D. Gelles, Jarvier N. Mohammed, Luis C. Santos, Diana Legarda, Adrian T. Ting, Jerry E. Chipuk. https://www.cell.com/developmental-cell/fulltext/S1534-5807(19)30699-9

Off-target toxicity is a common mechanism of action of cancer drugs undergoing clinical trials [including caspase-3 activators] – Ann Lin , Christopher J. Giuliano, Ann Palladino, Kristen M. John, Connor Abramowicz, Monet Lou Yuan, Erin L. Sausville, Devon A. Lukow, Luwei Liu, Alexander R. Chait, Zachary C. Galluzzo, Clara Tucker, Jason M. Sheltzer. https://stm.sciencemag.org/content/11/509/eaaw8412

In the absence of apoptosis, myeloid cells arrest when deprived of growth factor, but remain viable by consuming extracellular glucose – Li Dong, Boris Reljic, Jen G. Cheung, Elizabeth S. Ng, Lisa M. Lindqvist, Andrew G. Elefanty, David L. Vaux and Hoanh Tran. https://www.nature.com/articles/s41418-019-0275-z

TNF Induces Pathogenic Programmed Macrophage Necrosis in Tuberculosis through a Mitochondrial-Lysosomal-Endoplasmic Reticulum Circuit – Francisco J. Roca, Laura J. Whitworth, Sarah Redmond, Ana A. Jones, Lalita Ramakrishnan. https://www.cell.com/cell/fulltext/S0092-8674(19)30892-X

Estrogen-Related Hormones Induce Apoptosis by Stabilizing Schlafen-12 Protein Turnover – Dianrong Li, Jie Chen, Youwei Ai, Yang Cao, Xiangbin Qi, Xiaodong Wang. https://www.cell.com/molecular-cell/fulltext/S1097-2765(19)30497-6


Population Dynamics in Cell Death: Mechanisms of Propagation – Michelle Riegman, Michelle S. Bradbury, Michael Overholtzer. https://www.cell.com/trends/cancer/fulltext/S2405-8033(19)30147-5

Apoptotic cell death regulation in neurons – Emilie Hollville, Selena E. Romero, Mohanish Deshmukh. https://febs.onlinelibrary.wiley.com/doi/full/10.1111/febs.14970


The Neural Crest Pitches In to Remove Apoptotic Debris – Aglaja Kopf, Michael Sixt. https://www.cell.com/cell/fulltext/S0092-8674(19)30966-3

The Dark Side of Estrogen Stops Translation to Induce Apoptosis – Heather M. Lamb, J. Marie Hardwick. https://www.cell.com/molecular-cell/fulltext/S1097-2765(19)30661-6


ApoList – August 2019

Necroptosis and RIP kinases

RIPK3 Activation Leads to Cytokine Synthesis that Continues after Loss of Cell Membrane Integrity – Susana L. Orozco, Brian P. Daniels, Nader Yatim, Michelle N. Messmer, Giovanni Quarato, Haiyin Chen-Harris, Sean P. Cullen, Annelise G. Snyder, Pooja Ralli-Jain, Sharon Frase, Stephen W.G. Tait, Douglas R. Green, Matthew L. Albert, Andrew Oberst. https://www.cell.com/cell-reports/fulltext/S2211-1247(19)30981-7

The AMPK–Parkin axis negatively regulates necroptosis and tumorigenesis by inhibiting the necrosome – Seung Baek Lee, Jung Jin Kim, Sang-Ah Han, Yingfang Fan, Li-Sha Guo, Khaled Aziz, Somaira Nowsheen, Sung Sun Kim, Seon-Young Park, Qifeng Luo, Jin Ook Chung, Sung Il Choi, Asef Aziz, Ping Yin, Seo-Yun Tong, Fabienne C. Fiesel, Wolfdieter Springer, Jin-San Zhang and Zhenkun Lou. https://www.nature.com/articles/s41556-019-0356-8

TAM Kinases Promote Necroptosis by Regulating Oligomerization of MLKL – Ayaz Najafov, Adnan K. Mookhtiar, Hoang Son Luu, Alban Ordureau, Heling Pan, Palak P. Amin, Ying Li, Qingxian Lu, Junying Yuan. https://www.cell.com/molecular-cell/fulltext/S1097-2765(19)30394-6

Bcl-2 family proteins

BIK ubiquitination by the E3 ligase Cul5-ASB11 determines cell fate during cellular stress – Fei-Yun Chen, Min-Yu Huang, Yu-Min Lin, Chi-Huan Ho, Shu-Yu Lin, Hsin-Yi Chen, Mien-Chie Hung, Ruey-Hwa Chen. http://jcb.rupress.org/content/early/2019/08/05/jcb.201901156

The CUL5 ubiquitin ligase complex mediates resistance to CDK9 and MCL1 inhibitors in lung cancer cells – Shaheen Kabir, Justin Cidado, Courtney Andersen, Cortni Dick, Pei-Chun Lin, Therese Mitros, Hong Ma, Seung Hyun Baik, Matthew A Belmonte, Lisa Drew, Jacob E Corn. https://elifesciences.org/articles/44288

Prediction of venetoclax activity in precursor B-ALL by functional assessment of apoptosis signaling – Felix Seyfried, Salih Demir, Rebecca Louise Hörl, Felix Uli Stirnweiß, Jeremy RyanAnnika Scheffold, , Mariana Villalobos-Ortiz, Elena Boldrin, Julia Zinngrebe, Stefanie Enzenmüller, Silvia Jenni, Yi-Chien Tsai, Beat Bornhauser, Axel Fürstberger, Johann Michael Kraus, Hans Armin Kestler, Jean-Pierre Bourquin, Stephan Stilgenbauer, Anthony Letai, Klaus-Michael Debatin and Lüder Hinrich Meyer. https://www.nature.com/articles/s41419-019-1801-0

Noxa mitochondrial targeting domain induces necrosis via VDAC2 and mitochondrial catastrophe – Ji-Hye Han, Junghee Park, Seung-Hyun Myung, Sung Hang Lee, Hwa-Young Kim, Kyung Sook Kim, Young-Woo Seo and Tae-Hyoung Kim. https://www.nature.com/articles/s41419-019-1753-4

DHX33 Interacts with AP-2β To Regulate Bcl-2 Gene Expression and Promote Cancer Cell Survival – Jiuling Wang, Weimin Feng, Zhen Yuan, Jason D. Weber and Yandong Zhang. http://mcb.asm.org/content/39/17/e00017-19.abstract

Death receptors and IAPs

Characterization of TNF-induced cell death in Drosophila reveals caspase- and JNK-dependent necrosis and its role in tumor suppression – Mingli Li, Shiyao Sun, Jessica Priest, Xiaolin Bi and Yun Fan. https://www.nature.com/articles/s41419-019-1862-0

Hantavirus Inhibits TRAIL-Mediated Killing of Infected Cells by Downregulating Death Receptor 5 – Carles Solà-Riera, Shawon Gupta, Kimia T. Maleki, Patricia González-Rodriguez, Dalel Saidi, Christine L. Zimmer, Sindhu Vangeti, Laura Rivino, Yee-Sin Leo, David Chien Lye, Paul A. MacAry, Clas Ahlm, Anna Smed-Sörensen, Bertrand Joseph, Niklas K. Björkström, Hans-Gustaf Ljunggren, Jonas Klingström. https://www.cell.com/cell-reports/fulltext/S2211-1247(19)30970-2

The anticonvulsive Phenhydan® suppresses extrinsic cell death – Caroline Moerke, Isabel Jaco, Christin Dewitz, Tammo Müller, Annette V. Jacobsen, Jérémie Gautheron, Jürgen Fritsch, Jessica Schmitz, Jan Hinrich Bräsen, Claudia Günther, James M. Murphy, Ulrich Kunzendorf, Pascal Meier and Stefan Krautwald. https://www.nature.com/articles/s41418-018-0232-2

SMAC mimetics promote NIK-dependent inhibition of CD4+ TH17 cell differentiation – John Rizk , Joseph Kaplinsky, Rasmus Agerholm, Darshana Kadekar, Fredrik Ivars, William W. Agace, W. Wei-Lynn Wong, Matthew J. Szucs, Samuel A. Myers, Steven A. Carr, Ari Waisman, Vasileios Bekiaris. https://stke.sciencemag.org/content/12/596/eaaw3469


Caspase-8 modulates physiological and pathological angiogenesis during retina development – Nathalie Tisch, Aida Freire-Valls, Rosario Yerbes, Isidora Paredes, Silvia La Porta, Xiaohong Wang,Rosa Martín-Pérez, Laura Castro, Wendy Wei-Lynn Wong, Leigh Coultas, Boris Strilic, Hermann-Josef Gröne, Thomas Hielscher, Carolin Mogler, Ralf Adams, Peter Heiduschka, Lena Claesson-Welsh,Massimiliano Mazzone, Abelardo López-Rivas, Thomas Schmidt, Hellmut G. Augustin and Carmen Ruiz de Almodovar. https://www.jci.org/articles/view/122767

Caspase-2 promotes AMPA receptor internalization and cognitive flexibility via mTORC2-AKT-GSK3β signaling – Zhi-Xiang Xu, Ji-Wei Tan, Haifei Xu, Cassandra J. Hill, Olga Ostrovskaya, Kirill A. Martemyanov and Baoji Xu. https://www.nature.com/articles/s41467-019-11575-1

The cleavage of gasdermin D by caspase-11 promotes tubular epithelial cell pyroptosis and urinary IL-18 excretion in acute kidney injury – Miao N, Yin F, Xie H, Wang Y, Xu Y, Shen Y, Xu D, Yin J, Wang B, Zhou Z, Cheng Q, Chen P, Xue H, Zhou L, Liu J, Wang X, Zhang W, Lu L. https://www.ncbi.nlm.nih.gov/pubmed/31405732

Caspase-mediated cleavage of IRE1 controls apoptotic cell commitment during endoplasmic reticulum stress – Anna Shemorry, Jonathan M Harnoss, Ofer Guttman, Scot A Marsters, László G Kőműves, David A Lawrence, Avi Ashkenazi. https://elifesciences.org/articles/47084

Efferocytosis / immunogenicity

Long-term tolerance of islet allografts in nonhuman primates induced by apoptotic donor leukocytes – Amar Singh, Sabarinathan Ramachandran, Melanie L. Graham, Saeed Daneshmandi, David Heller, Wilma Lucia Suarez-Pinzon, Appakalai N. Balamurugan, Jeffrey D. Ansite, Joshua J. Wilhelm, Amy Yang, Ying Zhang, Nagendra P. Palani, Juan E. Abrahante, Christopher Burlak, Stephen D. Miller, Xunrong Luo and Bernhard J. Hering. https://www.nature.com/articles/s41467-019-11338-y


ATP induces caspase-3/gasdermin E-mediated pyroptosis in NLRP3 pathway-blocked murine macrophages – Chen-Ying Zeng, Chen-Guang Li, Jun-Xiang Shu, Li-Hui Xu, Dong-Yun Ouyang, Feng-Yi Mai, Qiong-Zhen Zeng, Cheng-Cheng Zhang, Rui-Man Li and Xian-Hui He. https://link.springer.com/article/10.1007/s10495-019-01551-x


NAD+ cleavage activity by animal and plant TIR domains in cell death pathways – Shane Horsefield, Hayden Burdett, Xiaoxiao Zhang, Mohammad K. Manik, Yun Shi, Jian Chen, Tiancong Qi, Jonathan Gilley, Jhih-Siang Lai, Maxwell X. Rank, Lachlan W. Casey, Weixi Gu, Daniel J. Ericsson, Gabriel Foley, Robert O. Hughes, Todd Bosanac, Mark von Itzstein, John P. Rathjen, Jeffrey D. Nanson, Mikael Boden, Ian B. Dry, Simon J. Williams, Brian J. Staskawicz, Michael P. Coleman, Thomas Ve, Peter N. Dodds, Bostjan Kobe. https://science.sciencemag.org/content/365/6455/793

TIR domains of plant immune receptors are NAD+-cleaving enzymes that promote cell death – Li Wan, Kow Essuman, Ryan G. Anderson, Yo Sasaki, Freddy Monteiro, Eui-Hwan Chung, Erin Osborne Nishimura, Aaron DiAntonio, Jeffrey Milbrandt, Jeffery L. Dangl, Marc T. Nishimura. https://science.sciencemag.org/content/365/6455/799

MYC paralog-dependent apoptotic priming orchestrates a spectrum of vulnerabilities in small cell lung cancer – Marcel A. Dammert, Johannes Brägelmann, Rachelle R. Olsen, Stefanie Böhm, Niloufar Monhasery, Christopher P. Whitney, Milind D. Chalishazar, Hannah L. Tumbrink, Matthew R. Guthrie, Sebastian Klein, Abbie S. Ireland, Jeremy Ryan, Anna Schmitt, Annika Marx, Luka Ozretić, Roberta Castiglione, Carina Lorenz, Ron D. Jachimowicz, Elmar Wolf, Roman K. Thomas, John T. Poirier, Reinhard Büttner, Triparna Sen, Lauren A. Byers, H. Christian Reinhardt, Anthony Letai, Trudy G. Oliver and Martin L. Sos. https://www.nature.com/articles/s41467-019-11371-x

Meiotic viral attenuation through an ancestral apoptotic pathway [yeast] – Jie Gao, Sabrina Chau, Fuad Chowdhury, Tina Zhou, Saif Hossain, G. Angus McQuibban and Marc D. Meneghini. https://www.pnas.org/content/116/33/16454.abstract?etoc

Inhibition of mitochondrial permeability transition by deletion of the ANT family and CypD – Jason Karch , Michael J. Bround, Hadi Khalil, Michelle A. Sargent, Nadina Latchman, Naohiro Terada, Pablo M. Peixoto, Jeffery D. Molkentin. https://advances.sciencemag.org/content/5/8/eaaw4597

Reviews / comments

Parkin inhibits necroptosis to prevent cancer – Kai Cao and Stephen W. G. Tait. https://www.nature.com/articles/s41556-019-0350-1

Parkin protects against necroptosis – Wei Wong. https://stke.sciencemag.org/content/12/595/eaaz1464

Parkin and AMPK team up against necroptosis – Paulina Strzyz. https://www.nature.com/articles/s41580-019-0165-8

Apoptosis regulation in the penumbra after ischemic stroke: expression of pro- and antiapoptotic proteins – Anatoly B. Uzdensky. https://link.springer.com/article/10.1007/s10495-019-01556-6

Still on time to register for ECDO conference 2019 in Dresden – https://www.ecdo.eu/ecdo2019/

ApoList – July 2019


Mitochondria and Bcl-2 family proteins

BCL-2 family protein BOK is a positive regulator of uridine metabolism in mammals – Rahul Srivastava, Zhipeng Cao, Christina Nedeva, Samara Naim, Daniel Bachmann, Tatiana Rabachini, Lahiru Gangoda, Sanjay Shahi, Jason Glab, Joseph Menassa, Laura Osellame, Tao Nelson, Yuniel Fernandez-Marrero, Fiona Brown, Andrew Wei, Francine Ke, Lorraine O’Reilly, Marcel Doerflinger, Cody Allison, Andrew Kueh, Rob Ramsay, Brian J. Smith, Suresh Mathivanan, Thomas Kaufmann and Hamsa Puthalakath. https://www.pnas.org/content/116/31/15469.abstract?etoc

Phenotypic selection with an intrabody library reveals an anti-apoptotic function of PKM2 requiring Mitofusin-1 – Liu, T., Kuwana, T., Zhang, H., Vander Heiden, M. G., Lerner, R. A. and Newmeyer, D. D. https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.2004413

The mitophagy receptor Bcl-2–like protein 13 stimulates adipogenesis by regulating mitochondrial oxidative phosphorylation and apoptosis in mice – Makoto Fujiwara, Li Tian, Phuong T. Le, Victoria E. DeMambro, Kathleen A. Becker, Clifford J. Rosen and Anyonya R. Guntur. http://www.jbc.org/content/early/2019/07/02/jbc.RA119.008630.abstract

JNK1 regulates RANKL-induced osteoclastogenesis via activation of a novel Bcl-2-Beclin1-autophagy pathway – Dianshan Ke, Lianmei Ji, Yu Wang, Xiaomin Fu, Jinyan Chen, Fan Wang, Dongbao Zhao, Ying Xue, Xuhua Lan and Jianming Hou. https://www.fasebj.org/doi/abs/10.1096/fj.201802597RR

Structural and functional analyses of hepatitis B virus X protein BH3-like domain and Bcl-xL interaction – Tian-Ying Zhang, Hong-Ying Chen, Jia-Li Cao, Hua-Long Xiong, Xiao-Bing Mo, Tian-Liang Li, Xiao-Zhen Kang, Jing-Hua Zhao, Bo Yin, Xiang Zhao, Cheng-Hao Huang, Quan Yuan, Ding Xue, Ning-Shao Xia and Y. Adam Yuan. https://www.nature.com/articles/s41467-019-11173-1

DRP-1 functions independently of mitochondrial structural perturbations to facilitate BH3 mimetic-mediated apoptosis – Mateus Milani, Alison J. Beckett, Aoula Al-Zebeeby, Xu Luo, Ian A. Prior, Gerald M. Cohen and Shankar Varadarajan. https://www.nature.com/articles/s41420-019-0199-x

Mcl-1 and Bcl-xL are essential for survival of the developing nervous system – Lauren C. Fogarty, Robert T. Flemmer, Brittany A. Geizer, Maria Licursi, Ahila Karunanithy, Joseph T. Opferman, Kensuke Hirasawa and Jacqueline L. Vanderluit. https://www.nature.com/articles/s41418-018-0225-1

Recipient BCL2 inhibition and NK cell ablation form part of a reduced intensity conditioning regime that improves allo-bone marrow transplantation outcomes – Yuhao Jiao, Joanne E. Davis, Jai Rautela, Emma M. Carrington, Mandy J. Ludford-Menting, Wilford Goh, Rebecca B. Delconte, Fernando Souza-Fonseca-Guimaraes, Rachel Koldej, Daniel Gray, David Huang, Ben T. Kile, Andrew M. Lew, David S. Ritchie and Nicholas D. Huntington. https://www.nature.com/articles/s41418-018-0228-y

Bcl-2 family inhibitors

BH3 profiling discriminates on-target small molecule BH3 mimetics from putative mimetics – Mariana Villalobos-Ortiz, Jeremy Ryan, Thelma N. Mashaka, Joseph T. Opferman and Anthony Letai. https://www.nature.com/articles/s41418-019-0391-9

Targeting Mitochondrial Structure Sensitizes Acute Myeloid Leukemia to Venetoclax Treatment – Xufeng Chen, Christina Glytsou, Hua Zhou, Sonali Narang, Denis E. Reyna, Andrea Lopez, Theodore Sakellaropoulos, Yixiao Gong, Andreas Kloetgen, Yoon Sing Yap, Eric Wang, Evripidis Gavathiotis, Aristotelis Tsirigos, Raoul Tibes and Iannis Aifantis. http://cancerdiscovery.aacrjournals.org/content/9/7/890

The TP53 Apoptotic Network Is a Primary Mediator of Resistance to BCL2 Inhibition in AML Cells – Tamilla Nechiporuk, Stephen E. Kurtz, Olga Nikolova, Tingting Liu, Courtney L. Jones, Angelo D’Alessandro, Rachel Culp-Hill, Amanda d’Almeida, Sunil K. Joshi, Mara Rosenberg, Cristina E. Tognon, Alexey V. Danilov, Brian J. Druker, Bill H. Chang, Shannon K McWeeney and Jeffrey W. Tyner. http://cancerdiscovery.aacrjournals.org/content/9/7/910

Cotargeting of BCL2 with Venetoclax and MCL1 with S63845 Is Synthetically Lethal In Vivo in Relapsed Mantle Cell Lymphoma – Dana Prukova, Ladislav Andera, Zuzana Nahacka, Jana Karolova, Michael Svaton, Magdalena Klanova, Ondrej Havranek, Jan Soukup, Karla Svobodova, Zuzana Zemanova, Diana Tuskova, Eva Pokorna, Karel Helman, Kristina Forsterova, Mariana Pacheco-Blanco, Petra Vockova, Adela Berkova, Eva Fronkova, Marek Trneny and Pavel Klener. http://clincancerres.aacrjournals.org/content/25/14/4455

Efficacy of venetoclax in relapsed chronic lymphocytic leukemia is influenced by disease and response variables – Andrew W. Roberts, Shuo Ma, Thomas J. Kipps, Steven E. Coutre, Matthew S.Davids, Barbara Eichhorst, Michael Hallek, John C. Byrd, KathryHumphrey, Lang Zhou, Brenda Chyla, Jacqueline Nielsen, Jalaja Potluri, Su Young Kim, Maria Verdugo, Stephan Stilgenbauer, William G. Wierda and John F. Seymour. http://bloodjournal.org/content/134/2/111.abstract?etoc

Tumor Lysis, Adverse Events, and Dose Adjustments in 297 Venetoclax-Treated CLL Patients in Routine Clinical Practice – Lindsey E. Roeker, Christopher P. Fox, Toby A. Eyre, Danielle M. Brander, John N. Allan, Stephen J. Schuster, Chadi Nabhan, Brian T. Hill, Nirav N. Shah, Frederick Lansigan, Maryam Yazdy, Bruce D. Cheson, Nicole Lamanna, Arun K. Singavi, Catherine C. Coombs, Paul M. Barr, Alan P. Skarbnik, Mazyar Shadman, Chaitra S. Ujjani, Hande H. Tuncer, Allison M. Winter, Joanna Rhodes, Colleen Dorsey, Hannah Morse, Charlene Kabel, John M. Pagel, Annalynn M. Williams, Ryan Jacobs, Andre Goy, Sivraj Muralikrishnan, Laurie Pearson, Andrea Sitlinger, Neil Bailey, Anna Schuh, Amy A. Kirkwood and Anthony R. Mato. http://clincancerres.aacrjournals.org/content/25/14/4264

Death receptors

TNFR1 membrane reorganization promotes distinct modes of TNFα signaling – Penny E. Morton , Camille Perrin, James Levitt, Daniel R. Matthews, Richard J. Marsh, Rosemary Pike, David McMillan, Alison Maloney, Simon Poland, Simon Ameer-Beg, Maddy Parsons. https://stke.sciencemag.org/content/12/592/eaaw2418

Dendritic cell NLRC4 regulates influenza A virus–specific CD4+ T cell responses through FasL expression – Emma E. Hornick, Jargalsaikhan Dagvadorj, Zeb R. Zacharias, Ann M. Miller, Ryan A. Langlois, Peter Chen, Kevin L. Legge, Gail A. Bishop, Fayyaz S. Sutterwala and Suzanne L. Cassel. https://www.jci.org/articles/view/124937

Fas signaling-mediated TH9 cell differentiation favors bowel inflammation and antitumor functions – Yingying Shen, Zhengbo Song, Xinliang Lu, Zeyu Ma, Chaojie Lu, Bei Zhang, Yinghu Chen, Meng Duan, Lionel Apetoh, Xu Li, Jufeng Guo, Ying Miao, Gensheng Zhang, Diya Yang, Zhijian Cai and Jianli Wang. https://www.nature.com/articles/s41467-019-10889-4

Crystal structure and activation mechanism of DR3 death domain – Xueying Yin, Wenqian Li, Huan Ma, Weihong Zeng, Chao Peng, Yajuan Li, Muziying Liu, Quan Chen, Rongbin Zhou, Tengchuan Jin. https://febs.onlinelibrary.wiley.com/doi/10.1111/febs.14834

The combination of TPL2 knockdown and TNFα causes synthetic lethality via caspase-8 activation in human carcinoma cell lines – Oksana B. Serebrennikova, Maria D. Paraskevopoulou, Elia Aguado-Fraile, Vasiliki Taraslia, Wenying Ren, Geeta Thapa, Jatin Roper, Keyong Du, Carlo M. Croce and Philip N. Tsichlis. https://www.pnas.org/content/116/28/14039.abstract

Minimal dosing of leukocyte targeting TRAIL decreases triple-negative breast cancer metastasis following tumor resection – Nidhi Jyotsana, Zhenjiang Zhang, Lauren E. Himmel, Fang Yu and Michael R. King. https://advances.sciencemag.org/content/5/7/eaaw4197

Augmenting Immunotherapy Impact by Lowering Tumor TNF Cytotoxicity Threshold – David W. Vredevoogd, Thomas Kuilman, Maarten A. Ligtenberg, Julia Boshuizen, Kelly E. Stecker, Beaunelle de Bruijn, Oscar Krijgsman, Xinyao Huang, Juliana C.N. Kenski, Ruben Lacroix, Riccardo Mezzadra, Raquel Gomez-Eerland, Mete Yildiz, Ilknur Dagidir, Georgi Apriamashvili, Nordin Zandhuis, Vincent van der Noort, Nils L. Visser, Christian U. Blank, Maarten Altelaar, Ton N. Schumacher, Daniel S. Peeper. https://www.cell.com/cell/fulltext/S0092-8674(19)30677-4


Specificity for latent C termini links the E3 ubiquitin ligase CHIP to caspases – Matthew Ravalin, Panagiotis Theofilas, Koli Basu, Kwadwo A. Opoku-Nsiah, Victoria A. Assimon, Daniel Medina-Cleghorn, Yi-Fan Chen, Markus F. Bohn, Michelle Arkin, Lea T. Grinberg, Charles S. Craik and Jason E. Gestwicki. https://www.nature.com/articles/s41589-019-0322-6

Cullin-4B E3 ubiquitin ligase mediates Apaf-1 ubiquitination to regulate caspase-9 activity – Eri Ohta, Masanori Itoh, Masashi Ueda, Yoko Hida, Miao-xing Wang, Miki Hayakawa-Ogura, Shimo Li, Emika Nishida, Kazunori Ohta, Tana, Saiful Islam, Kiyomi Nakagawa, Tomomi Sunayama, Huayue Chen, So Hirata, Masashi Endo, Yoya Ohno, Toshiyuki Nakagawa. https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0219782

Caspase-8 restricts antiviral CD8 T cell hyperaccumulation – Yanjun Feng, Lisa P. Daley-Bauer, Linda Roback, Hongyan Guo, Heather S. Koehler, Marc Potempa, Lewis L. Lanier and Edward S. Mocarski. https://www.pnas.org/content/116/30/15170.abstract?etoc

E1A oncogene induced sensitization to NK cell induced apoptosis requires PIDD and Caspase-2 – Jay R. Radke, John M. Routes and James L. Cook. https://www.nature.com/articles/s41420-019-0189-z

Necroptosis and/or RIP kinases

Intratumoral activation of the necroptotic pathway components RIPK1 and RIPK3 potentiates antitumor immunity – Annelise G. Snyder, Nicholas W. Hubbard, Michelle N. Messmer, Sigal B. Kofman, Cassidy E. Hagan, Susana L. Orozco, Kristy Chiang, Brian P. Daniels, David Baker and Andrew Oberst. https://immunology.sciencemag.org/content/4/36/eaaw2004.long

Central nervous system regeneration is driven by microglia necroptosis and repopulation – Amy F. Lloyd, Claire L. Davies, Rebecca K. Holloway, Yasmine Labrak, Graeme Ireland, Dario Carradori, Alessandra Dillenburg, Eva Borger, Daniel Soong, Jill C. Richardson, Tanja Kuhlmann, Anna Williams, Jeffrey W. Pollard, Anne des Rieux, Josef Priller and Veronique E. Miron. https://www.nature.com/articles/s41593-019-0418-z


Crystal Structures of the Full-Length Murine and Human Gasdermin D Reveal Mechanisms of Autoinhibition, Lipid Binding, and Oligomerization – Zhonghua Liu, Chuanping Wang, Jie Yang, Bowen Zhou, Rui Yang, Rajesh Ramachandran, Derek W. Abbott, Tsan Sam Xiao. https://www.cell.com/immunity/fulltext/S1074-7613(19)30197-9


Serum FHR1 binding to necrotic-type cells activates monocytic inflammasome and marks necrotic sites in vasculopathies – Sarah Irmscher, Silke R. Brix, Svante L. H. Zipfel, Luke D. Halder, Sibel Mutlutürk, Sonia Wulf, Evaldas Girdauskas, Hermann Reichenspurner, Rolf A. K. Stahl, Berit Jungnickel, Thorsten Wiech, Peter F. Zipfel and Christine Skerk. https://www.nature.com/articles/s41467-019-10766-0

Intercellular interaction dictates cancer cell ferroptosis via NF2–YAP signalling – Jiao Wu, Alexander M. Minikes, Minghui Gao, Huijie Bian, Yong Li, Brent R. Stockwell, Zhi-Nan Chen and Xuejun Jiang. https://www.nature.com/articles/s41586-019-1426-6

Clockophagy is a novel selective autophagy process favoring ferroptosis – Minghua Yang, Pan Chen, Jiao Liu, Shan Zhu, Guido Kroemer, Daniel J. Klionsky, Michael T. Lotze, Herbert J. Zeh, Rui Kang and Daolin Tang. https://advances.sciencemag.org/content/5/7/eaaw2238.full

Curcumin reduces renal damage associated with rhabdomyolysis by decreasing ferroptosis-mediated cell death – Melania Guerrero-Hue, Cristina García-Caballero, Alejandra Palomino-Antolín, Alfonso Rubio-Navarro, Cristina Vázquez-Carballo, Carmen Herencia, Diego Martín-Sanchez, Víctor Farré-Alins, Javier Egea, Pablo Cannata, Manuel Praga, Alberto Ortiz, Jesús Egido, Ana Belén Sanz and Juan Antonio Moreno. https://www.fasebj.org/doi/abs/10.1096/fj.201900077R?ai=s4&ui=ly8&af=T


Inflammatory caspase regulation: maintaining balance between inflammation and cell death in health and disease – Beatriz E. Bolívar, Tiphanie P. Vogel, Lisa Bouchier‐Hayes. https://febs.onlinelibrary.wiley.com/doi/10.1111/febs.14926

Mitochondria and Inflammation: Cell Death Heats Up – Esmee Vringer and Stephen W. G. Tait. https://www.frontiersin.org/articles/10.3389/fcell.2019.00100/full

Cell death–mediated cytokine release and its therapeutic implications – David E. Place and Thirumala-Devi Kanneganti. http://jem.rupress.org/content/216/7/1474?etoc


Keeping the Death Protein in Check – Longfei Wang, Hao Wu. https://www.cell.com/immunity/fulltext/S1074-7613(19)30281-X

Mitochondrial Homeostasis in AML and Gasping for Response in Resistance to BCL2 Blockade – Michael R. Savona and Jeffrey C. Rathmell. http://cancerdiscovery.aacrjournals.org/content/9/7/831

A Physiological Function for Ferroptosis in Tumor Suppression by the Immune System – Brent R. Stockwell, Xuejun Jiang. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(19)30315-8

ApoList – June 2019


Bcl-2 family proteins

A non‐death function of the mitochondrial apoptosis apparatus in immunity – Dominik Brokatzky, Benedikt Dörflinger, Aladin Haimovici, Arnim Weber, Susanne Kirschnek, Juliane Vier,Arlena Metz, Julia Henschel, Tobias Steinfeldt, Ian E Gentle, Georg Häcker. https://www.embopress.org/doi/10.15252/embj.2018100907

Structures of BCL-2 in complex with venetoclax reveal the molecular basis of resistance mutations – Richard W. Birkinshaw, Jia-nan Gong, Cindy S. Luo, Daisy Lio, Christine A. White, Mary Ann Anderson, Piers Blombery, Guillaume Lessene, Ian J. Majewski, Rachel Thijssen, Andrew W. Roberts, David C. S. Huang, Peter M. Colman and Peter E. Czabotar. https://www.nature.com/articles/s41467-019-10363-1

α7 nicotinic acetylcholine receptor upregulation by anti-apoptotic Bcl-2 proteins – Brent Dawe, Hong Yu, Shenyan Gu, Alissa N. Blackler, Jose A. Matta, Edward R. Siuda, Elizabeth B. Rex and David S. Bredt. https://www.nature.com/articles/s41467-019-10723-x

Impact of elevated anti-apoptotic MCL-1 and BCL-2 on the development and treatment of MLL-AF9 AML in mice – Natasha S. Anstee, Rebecca A. Bilardi, Ashley P. Ng, Zhen Xu, Mikara Robati, Cassandra J. Vandenberg and Suzanne Cory. https://www.nature.com/articles/s41418-018-0209-1

Alcohol exposure alters pre-mRNA splicing of antiapoptotic Mcl-1L isoform and induces apoptosis in neural progenitors and immature neurons – Martina Donadoni, Stephanie Cicalese, Dipak K. Sarkar, Sulie L. Chang and Ilker Kudret Sariyer. https://www.nature.com/articles/s41419-019-1673-3

Resistance to anti-microtubule drug-induced cell death is determined by regulation of BimEL expression – Weimei Ruan, Gireedhar Venkatachalam, Radoslaw Mikolaj Sobota, Liyan Chen, Loo Chien Wang, Alena Jacobson, Kathirvel Paramasivam and Uttam Surana. https://www.nature.com/articles/s41388-019-0727-4

MiR-35 buffers apoptosis thresholds in the C. elegans germline by antagonizing both MAPK and core apoptosis pathways – Anh T. Tran, Eric M. Chapman, Mathieu N. Flamand, Bin Yu, Samuel J. Krempel, Thomas F. Duchaine, Matthew Eroglu and W. Brent Derry. https://www.nature.com/articles/s41418-019-0325-6

XPO1 inhibitor KPT-330 synergizes with Bcl-xL inhibitor to induce cancer cell apoptosis by perturbing rRNA processing and Mcl-1 protein synthesis – Zhi-Chuan Zhu, Ji-Wei Liu, Can Yang, Miao Zhao and Zhi-Qi Xiong. https://www.nature.com/articles/s41419-019-1627-9

Death receptors

DR4-Ser424 O-GlcNAcylation Promotes Sensitization of TRAIL-Tolerant Persisters and TRAIL-Resistant Cancer Cells to Death – Hyeonjeong Lee, Yumin Oh, Young-Jun Jeon, Song-Yi Lee, Hyunjoo Kim, Ho-June Lee and Yong-Keun Jung. http://cancerres.aacrjournals.org/content/79/11/2839

c-FLIP and CD95 signaling are essential for survival of renal cell carcinoma – Tobias Luebke, Lisa Schwarz, Yan Yan Beer, Sabrina Schumann, Maria Misterek, Frida Ewald Sander, Carlos Plaza-Sirvent and Ingo Schmitz. https://www.nature.com/articles/s41419-019-1609-y


Molecular basis of dimerization of initiator caspase was revealed by crystal structure of caspase-8 pro-domain – Hyun Ho Par. https://www.nature.com/articles/s41418-018-0200-x

Caspase-8 promotes c-Rel–dependent inflammatory cytokine expression and resistance against Toxoplasma gondii – Alexandra A. DeLaney, Corbett T. Berry, David A. Christian, Andrew Hart, Elisabet Bjanes, Meghan A. Wynosky-Dolfi, Xinyuan Li, Bart Tummers, Irina A. Udalova, Youhai H. Chen, Uri Hershberg, Bruce D. Freedman, Christopher A. Hunter and Igor E. Brodsky. https://www.pnas.org/content/116/24/11926.abstract?etoc

Gasdermin-D and Caspase-7 are the key Caspase-1/8 substrates downstream of the NAIP5/NLRC4 inflammasome required for restriction of Legionella pneumophila – Augusto V. Gonçalves, Shally R. Margolis , Gustavo F. S. Quirino, Danielle P. A. Mascarenhas, Isabella Rauch, Randilea D. Nichols, Eduard Ansaldo, May F. Fontana, Russell E. Vance and Dario S. Zamboni. https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1007886


Necroptosis mediators RIPK3 and MLKL suppress intracellular Listeria replication independently of host cell killing – Kazuhito Sai, Cameron Parsons, John S. House, Sophia Kathariou and Jun Ninomiya-Tsuji. http://jcb.rupress.org/content/218/6/1994

Discovery of potent necroptosis inhibitors targeting RIPK1 kinase activity for the treatment of inflammatory disorder and cancer metastasis – Jue Hou, Jie Ju, Zili Zhang, Cong Zhao, Zhanhui Li, Jiyue Zheng, Tian Sheng, Hongjian Zhang, Linkun Hu, Xiaoliang Yu, Wei Zhang, Yangxin Li, Meng Wu, Haikuo Ma, Xiaohu Zhang and Sudan He. https://www.nature.com/articles/s41419-019-1735-6

FKBP12 mediates necroptosis by initiating RIPK1–RIPK3–MLKL signal transduction in response to TNF receptor 1 ligation – Zicheng Wang, Jiannan Feng, Jiyun Yu and Guozhu Chen. http://jcs.biologists.org/content/132/10/jcs227777?etoc

Interferon-γ induces the cell surface exposure of phosphatidylserine by activating MLKL in the absence of caspase-8 activity – Jiancheng Chen, Shunsuke Kuroki, Masataka Someda and Shin Yonehara. http://www.jbc.org/content/early/2019/06/19/jbc.RA118.007161.abstract


Ferroptotic cell death and TLR4/Trif signaling initiate neutrophil recruitment after heart transplantation – Wenjun Li, Guoshuai Feng, Jason M. Gauthier, Inessa Lokshina, Ryuji Higashikubo, Sarah Evans, Xinping Liu, Adil Hassan, Satona Tanaka, Markus Cicka, Hsi-Min Hsiao, Daniel Ruiz-Perez, Andrea Bredemeyer, Richard W. Gross, Douglas L. Mann, Yulia Y. Tyurina, Andrew E. Gelman, Valerian E. Kagan, Andreas Linkermann, Kory J. Lavine and Daniel Kreisel. https://www.jci.org/articles/view/126428


A conserved CCM complex promotes apoptosis non-autonomously by regulating zinc homeostasis – Eric M. Chapman, Benjamin Lant, Yota Ohashi, Bin Yu, Michael Schertzberg, Christopher Go, Deepika Dogra, Janne Koskimäki, Romuald Girard, Yan Li, Andrew G. Fraser, Issam A. Awad, Salim Abdelilah-Seyfried, Anne-Claude Gingras and W. Brent Derry. https://www.nature.com/articles/s41467-019-09829-z

Discerning the mechanism of action of HtrA4: a serine protease implicated in the cell death pathway – Raghupathi Kummari, Shubhankar Dutta, Lalith K. Chaganti and Kakoli Bose. http://www.biochemj.org/content/476/10/1445?etoc

AIF-regulated oxidative phosphorylation supports lung cancer development – Shuan Rao, Laura Mondragón, Blanka Pranjic, Toshikatsu Hanada, Gautier Stoll, Thomas Köcher, Peng Zhang, Alexander Jais, Alexander Lercher, Andreas Bergthaler, Daniel Schramek, Katharina Haigh, Valentina Sica, Marion Leduc, Nazanine Modjtahedi, Tsung-Pin Pai, Masahiro Onji, Iris Uribesalgo, Reiko Hanada, Ivona Kozieradzki, Rubina Koglgruber, Shane J. Cronin, Zhigang She, Franz Quehenberger, Helmut Popper, Lukas Kenner, Jody J. Haigh, Oliver Kepp, Malgorzata Rak, Kaican Cai, Guido Kroemer and Josef M. Penninger. https://www.nature.com/articles/s41422-019-0181-4


Caspases in Cell Death, Inflammation, and Disease – Nina Van Opdenbosch, Mohamed Lamkanfi. https://www.cell.com/immunity/fulltext/S1074-7613(19)30240-7

Targeting Ferroptosis to Iron Out Cancer – Behrouz Hassannia, Peter Vandenabeele, Tom Vanden Berghe. https://www.cell.com/cancer-cell/fulltext/S1535-6108(19)30197-7

Ferroptosis at the crossroads of cancer-acquired drug resistance and immune evasion – José Pedro Friedmann Angeli, Dmitri V. Krysko and Marcus Conrad. https://www.nature.com/articles/s41568-019-0149-1

Molecular Comprehension of Mcl-1: From Gene Structure to Cancer Therapy – Viacheslav V. Senichkin, Alena Y. Streletskaia, Boris Zhivotovsky, Gelina S. Kopeina. https://www.cell.com/trends/cell-biology/fulltext/S0962-8924(19)30047-9

Autophagy-Independent Functions of the Autophagy Machinery – Lorenzo Galluzzi, Douglas R. Green. https://www.cell.com/cell/fulltext/S0092-8674(19)30554-9

FAIM: An Antagonist of Fas-Killing and Beyond – Jianxin Huo, Shengli Xu and Kong-Peng Lam. https://www.mdpi.com/2073-4409/8/6/541


Mitochondria and pathogen immunity: from killer to firestarter – Joel S Riley, Stephen WG Tait. https://www.embopress.org/doi/full/10.15252/embj.2019102325

Bayonets over bombs: RIPK3 and MLKL restrict Listeria without triggering necroptosis – Ting Zhang, Siddharth Balachandran. http://jcb.rupress.org/content/218/6/1773?etoc

A New Current for the Mitochondrial Permeability Transition – Massimo Bonora, Paolo Pinton. https://www.cell.com/trends/biochemical-sciences/fulltext/S0968-0004(19)30089-1

Cell Death: N-degrons Fine-Tune Pyroptotic Cell Demise – Mohamed A. Eldeeb, Mohamed A. Ragheb, Edward A. Fon. https://www.cell.com/current-biology/fulltext/S0960-9822(19)30537-8

Death Is Coming and the Clot Thickens, as Pyroptosis Feeds the Fire – Laura C. Burzynski, Murray C.H. Clarke. https://www.cell.com/immunity/fulltext/S1074-7613(19)30235-3

Cancer and the death domain – Wei Wong. https://stke.sciencemag.org/content/12/584/eaay2357


Bax channel triplet: co-operativity and voltage gating – Shang H. Lin, Nuval Cherian, Benjamin Wu, Hyo Phee, Christy Cho and Marco Colombini. http://www.biochemj.org/content/476/10/1571?etoc

ApoList – May 2019


Bcl-2 family proteins

BCL2 Amplicon Loss and Transcriptional Remodeling Drives ABT-199 Resistance in B Cell Lymphoma Models – Xiaohong Zhao, Yuan Ren, Matthew Lawlor, Bijal D. Shah, Paul M.C. Park, Tint Lwin, Xuefeng Wang, Kenian Liu, Michelle Wang, Jing Gao, Tao Li, Mousheng Xu, Ariosto S. Silva, Kaplan Lee, Tinghu Zhang, John M. Koomen, Huijuan Jiang, Praneeth R. Sudalagunta, Mark B. Meads, Fengdong Cheng, Chengfeng Bi, Kai Fu, Huitao Fan, William S. Dalton, Lynn C. Moscinski, Kenneth H. Shain, Eduardo M. Sotomayor, Gang Greg Wang, Nathanael S. Gray, John L. Cleveland, Jun Qi, Jianguo Tao. https://www.cell.com/cancer-cell/fulltext/S1535-6108(19)30200-4

Retromer facilitates the localization of Bcl-xL to the mitochondrial outer membrane – Trey Farmer, Katelyn L. O’Neill, Naava Naslavsky, Xu Luo and Steve Caplan. https://www.molbiolcell.org/doi/10.1091/mbc.E19-01-0044?ai=s5&ui=2oy6&af=T

Bcl-2 Is a Therapeutic Target for Hypodiploid B-Lineage Acute Lymphoblastic Leukemia – Ernesto Diaz-Flores, Evan Q. Comeaux, Kailyn L. Kim, Ella Melnik, Kyle Beckman, Kara L. Davis, Kevin Wu, Jon Akutagawa, Olga Bridges, Roberta Marino, Margo Wohlfeil, Benjamin S. Braun, Charles G. Mullighan and Mignon L. Loh. http://cancerres.aacrjournals.org/content/79/9/2339

Venetoclax plus R- or G-CHOP in non-Hodgkin lymphoma: results from the CAVALLI phase 1b trial – Andrew D. Zelenetz, Gilles Salles, Kylie D. Mason, Carla Casulo, Steven Le Gouill, Laurie H. Sehn, Herve Tilly, Guillaume Cartron, Martine E. D.  Chamuleau, Andre Goy, Constantine S. Tam, Pieternella J. Lugtenburg, Adam M. Petrich, Arijit Sinha, Divya Samineni, Sylvia Herter, Ellen Ingalla,  Edith Szafer-Glusman, Christian Klein, Deepak Sampath, Martin Kornacker, Mehrdad Mobasher and Franck Morschhauser. http://bloodjournal.org/content/133/18/1964.abstract?etoc

BCL-XL and MCL-1 are the key BCL-2 family proteins in melanoma cell survival – Erinna F. Lee, Tiffany J. Harris, Sharon Tran, Marco Evangelista, Surein Arulananda, Thomas John, Celeste Ramnac, Chloe Hobbs, Haoran Zhu, Gency Gunasingh, David Segal, Andreas Behren, Jonathan Cebon, Alexander Dobrovic, John M. Mariadason, Andreas Strasser, Leona Rohrbeck, Nikolas K. Haass, Marco J. Herold and W. Douglas Fairlie. https://www.nature.com/articles/s41419-019-1568-3

Non-canonical BAD activity regulates breast cancer cell and tumor growth via 14-3-3 binding and mitochondrial metabolism – Jasdeep Mann, John Maringa Githaka, Timothy W. Buckland, Ning Yang, Rachel Montpetit, Namrata Patel, Lei Li, Shairaz Baksh, Roseline Godbout, Hélène Lemieux and Ing Swie Goping. https://www.nature.com/articles/s41388-018-0673-6

Death receptors / IAPs / caspases

Ubiquitin Ligases cIAP1 and cIAP2 Limit Cell Death to Prevent Inflammation – Jieqiong Zhang, Joshua D. Webster, Debra L. Dugger, Tatiana Goncharov, Merone Roose-Girma, Jeffrey Hung, Youngsu C. Kwon, Domagoj Vucic, Kim Newton, Vishva M. Dixit. https://www.cell.com/cell-reports/fulltext/S2211-1247(19)30601-1

RUNX3 enhances TRAIL-induced apoptosis by upregulating DR5 in colorectal cancer – Bo Ram Kim, Seong Hye Park, Yoon A Jeong, Yoo Jin Na, Jung Lim Kim, Min Jee Jo, Soyeon Jeong, Hye Kyeong Yun, Sang Cheul Oh and Dae-Hee Lee. https://www.nature.com/articles/s41388-019-0693-x

Regulation of death receptor signaling by the autophagy protein TP53INP2 – Saška Ivanova, Mira Polajnar, Alvaro Jesus Narbona‐Perez, Maria Isabel Hernandez‐Alvarez, Petra Frager, Konstantin Slobodnyuk, Natalia Plana, Angel R Nebreda, Manuel Palacin, Roger R Gomis, Christian Behrends and Antonio Zorzano. http://EMBOJ.embopress.org/content/38/10/e99300

CrmA orthologs from diverse poxviruses potently inhibit caspases-1 and -8, yet cleavage site mutagenesis frequently produces caspase-1-specific variants – David T. Bloomer, Tanja Kitevska-Ilioski, Delara Pantaki-Eimany, Yanhao Ji, Mark A. Miles, Begona Heras and Christine J. Hawkins. http://www.biochemj.org/content/476/9/1335?etoc


IRF2 transcriptionally induces GSDMD expression for pyroptosis – Nobuhiko Kayagaki, Bettina L. Lee, Irma B. Stowe, Opher S. Kornfeld, Karen O’Rourke, Kathleen M. Mirrashidi, Benjamin Haley, Colin Watanabe, Merone Roose-Girma, Zora Modrusan, Sarah Kummerfeld, Rohit Reja, Yafei Zhang, Vicky Cho, T. Daniel Andrews, Lucy X. Morris, Christopher C. Goodnow, Edward M. Bertram and Vishva M. Dixit. https://stke.sciencemag.org/content/12/582/eaax4917

Caspase-1 initiates apoptosis in the absence of gasdermin D – Kohsuke Tsuchiya, Shinsuke Nakajima, Shoko Hosojima, Dinh Thi Nguyen, Tsuyoshi Hattori, Thuong Manh Le, Osamu Hori, Mamunur Rashid Mahib, Yoshifumi Yamaguchi, Masayuki Miura, Takeshi Kinoshita, Hiroko Kushiyama, Mayumi Sakurai, Toshihiko Shiroishi and Takashi Suda. https://www.nature.com/articles/s41467-019-09753-2

Extrinsic and intrinsic apoptosis activate pannexin‐1 to drive NLRP3 inflammasome assembly – Kaiwen W Chen, Benjamin Demarco, Rosalie Heilig, Kateryna Shkarina, Andreas Boettcher, Christopher J Farady, Pawel Pelczar and Petr Broz. http://EMBOJ.embopress.org/content/38/10/e101638?etoc

Diverse small molecules prevent macrophage lysis during pyroptosis – Wendy P. Loomis, Andreas B. den Hartigh, Brad T. Cookson and Susan L. Fink. https://www.nature.com/articles/s41419-019-1559-4


RIP1 inhibition blocks inflammatory diseases but not tumor growth or metastases – Snahel Patel, Joshua D. Webster, Eugene Varfolomeev, Youngsu C. Kwon, Jason H. Cheng, Juan Zhang, Debra L. Dugger, Kate E. Wickliffe, Allie Maltzman, Swathi Sujatha-Bhaskar, Pawan Bir Kohli, Sreema Ramaswamy, Gauri Deshmukh, Bianca M. Liederer, Rina Fong, Greg Hamilton, Patrick Lupardus, Patrick Caplazi, Wyne P. Lee, Menno van Lookeren Campagne, Adam Johnson, Brent S. McKenzie, Melissa R. Junttila, Kim Newton and Domagoj Vucic. https://www.nature.com/articles/s41418-019-0347-0

TRAF2 protects against cerebral ischemia-induced brain injury by suppressing necroptosis – Jie Li, Jingyu Zhang, Yusuo Zhang, Zichuang Wang, Yanmei Song, Shanwen Wei, Meijun He, Shoujiang You, Jia Jia and Jian Cheng. https://www.nature.com/articles/s41419-019-1558-5

Flotillin-mediated endocytosis and ALIX–syntenin-1–mediated exocytosis protect the cell membrane from damage caused by necroptosis – Weiliang Fan, Jia Guo, Beichen Gao, Wenbin Zhang, Liucong Ling, Tao Xu, Chenjie Pan, Lin Li, She Chen, Hua Wang, Jing Zhang and Xiaodong Wang. https://stke.sciencemag.org/content/12/583/eaaw3423


CD8+ T cells regulate tumour ferroptosis during cancer immunotherapy – Weimin Wang, Michael Green, Jae Eun Choi, Miguel Gijón, Paul D. Kennedy, Jeffrey K. Johnson, Peng Liao, Xueting Lang, Ilona Kryczek, Amanda Sell, Houjun Xia, Jiajia Zhou, Gaopeng Li, Jing Li, Wei Li, Shuang Wei, Linda Vatan, Hongjuan Zhang, Wojciech Szeliga, Wei Gu, Rebecca Liu, Theodore S. Lawrence, Candice Lamb, Yuri Tanno, Marcin Cieslik, Everett Stone, George Georgiou, Timothy A. Chan, Arul Chinnaiyan and Weiping Zou. https://www.nature.com/articles/s41586-019-1170-y

ALOX12 is required for p53-mediated tumour suppression through a distinct ferroptosis pathway – Bo Chu, Ning Kon, Delin Chen, Tongyuan Li, Tong Liu, Le Jiang, Shujuan Song, Omid Tavana and Wei Gu. https://www.nature.com/articles/s41556-019-0305-6

Curcumin reduces renal damage associated with rhabdomyolysis by decreasing ferroptosis-mediated cell death – Melania Guerrero-Hue, Cristina García-Caballero, Alejandra Palomino-Antolín, Alfonso Rubio-Navarro, Cristina Vázquez-Carballo, Carmen Herencia, Diego Martín-Sanchez, Víctor Farré-Alins, Javier Egea, Pablo Cannata, Manuel Praga, Alberto Ortiz, Jesús Egido, Ana Belén Sanz and Juan Antonio Moreno. https://www.fasebj.org/doi/abs/10.1096/fj.201900077R?ai=ts&ui=ly8&af=T


Analysis of extracellular vesicles generated from monocytes under conditions of lytic cell death – Amy A. Baxter, Thanh Kha Phan, Eric Hanssen, Michael Liem, Mark D. Hulett, Suresh Mathivanan and Ivan K. H. Poon. https://www.nature.com/articles/s41598-019-44021-9

Necrosis, apoptosis, necroptosis, three modes of action of dopaminergic neuron neurotoxins – Noëlle Callizot, Maud Combes, Alexandre Henriques, Philippe Poindron. https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215277

Drosophila p53 directs nonapoptotic programs in postmitotic tissue – Paula Kurtz, Amanda E. Jones, Bhavana Tiwari, Nichole Link, Annika Wylie, Charles Tracy, Helmut Krämer and John M. Abrams. https://www.molbiolcell.org/doi/10.1091/mbc.E18-12-0791?ai=s5&ui=2oy6&af=T


The Coming Decade of Cell Death Research: Five Riddles – Douglas R. Green. https://www.cell.com/cell/fulltext/S0092-8674(19)30443-X

Targeting RIPK1 for the treatment of human diseases – Alexei Degterev, Dimitry Ofengeim and Junying Yuan. https://www.pnas.org/content/116/20/9714.abstract

Modulation of CD95-mediated signaling by post-translational modifications: towards understanding CD95 signaling networks – Kamil Seyrek and Inna N. Lavrik. https://link.springer.com/article/10.1007/s10495-019-01540-0

The role of necroptosis in cancer: A double-edged sword? – Xia Qin, Dan Ma, Ye-xiong Tan, Hong-yang Wang, Zhenyu Cai. https://www.sciencedirect.com/science/article/abs/pii/S0304419X18302105


Chopping GSDMD: caspase‐8 has joined the team of pyroptosis‐mediating caspases – Anna M Gram, Lee M Booty and Clare E Bryant. http://EMBOJ.embopress.org/content/38/10/e102065?etoc

Venetoclax: R-CHOP rocket booster? – Charles Herbaux and Matthew S. Davids. http://bloodjournal.org/content/133/18/1922?etoc

Potential role of anastasis in cancer initiation and progression – Thirumal Raj, Supriya Kheur, Ramesh Bhonde, Archana A. Gupta, Vikrant R. Patil and Avinash Kharat. https://link.springer.com/article/10.1007/s10495-019-01538-8

Targeting MCL1, Companies Aim to Unblock Apoptosis – http://cancerdiscovery.aacrjournals.org/content/9/5/572

Venetoclax–Obinutuzumab Elicits High Response Rates in CLL – http://cancerdiscovery.aacrjournals.org/content/9/5/OF5

ApoList – April 2019

If wish to subscribe please visit the following link – http://eepurl.com/cvmBlv

Mitochondrial pathway

Gasdermin pores permeabilize mitochondria to augment caspase-3 activation during apoptosis and inflammasome activation – Corey Rogers, Dan A. Erkes, Alexandria Nardone, Andrew E. Aplin, Teresa Fernandes-Alnemri and Emad S. Alnemri. https://www.nature.com/articles/s41467-019-09397-2

Intrinsic apoptosis shapes the tumor spectrum linked to inactivation of the deubiquitinase BAP1 – Meng He, Mira S. Chaurushiya, Joshua D. Webster, Sarah Kummerfeld, Rohit Reja, Subhra Chaudhuri, Ying-Jiun Chen, Zora Modrusan, Benjamin Haley, Debra L. Dugger, Jeffrey Eastham-Anderson, Shari Lau, Anwesha Dey, Roger Caothien, Merone Roose-Girma, Kim Newton, Vishva M. Dixit. https://science.sciencemag.org/content/364/6437/283.abstract

Cytochrome c Deficiency Confers Apoptosome and Mitochondrial Dysfunction in African-American Men with Prostate Cancer – Rahul Kumar, Tariq A. Bhat, Elise M. Walsh, Ajay K. Chaudhary, Jordan O’Malley, Johng S. Rhim, Jianmin Wang, Carl D. Morrison, Kristopher Attwood, Wiam Bshara, James L. Mohler, Neelu Yadav and Dhyan Chandra. http://cancerres.aacrjournals.org/content/79/7/1353

Ceramides bind VDAC2 to trigger mitochondrial apoptosis – Shashank Dadsena, Svenja Bockelmann, John G. M. Mina, Dina G. Hassan, Sergei Korneev, Guilherme Razzera, Helene Jahn, Patrick Niekamp, Dagmar Müller, Markus Schneider, Fikadu G. Tafesse, Siewert J. Marrink, Manuel N. Melo and Joost C. M. Holthuis. https://www.nature.com/articles/s41467-019-09654-4

Mitochondrial pathway – Bcl-2 family proteins

BAX Activation: Mutations Near Its Proposed Non-canonical BH3 Binding Site Reveal Allosteric Changes Controlling Mitochondrial Association – Michael A. Dengler, Adeline Y. Robin, Leonie Gibson, Mark X. Li, Jarrod J. Sandow, Sweta Iyer, Andrew I. Webb, Dana Westphal, Grant Dewson, Jerry M. Adams. https://www.cell.com/cell-reports/fulltext/S2211-1247(19)30356-0

Bcl-2 and IP3 compete for the ligand-binding domain of IP3Rs modulating Ca2+ signaling output – Hristina Ivanova, Larry E. WagnerII, Akihiko Tanimura, Elien Vandermarliere, Tomas Luyten, Kirsten Welkenhuyzen, Kamil J. Alzayady, Liwei Wang, Kozo Hamada, Katsuhiko Mikoshiba, Humbert De Smedt, Lennart Martens, David I. Yule, Jan B. Parys, Geert Bultynck. https://link.springer.com/article/10.1007/s00018-019-03091-8

Discovery of Potent Myeloid Cell Leukemia-1 (Mcl-1) Inhibitors that Demonstrate in vivo Activity in Mouse Xenograft Models of Human Cancer – Lee T, Christov PP, Shaw S, Tarr JC, Zhao B, Veerasamy N, Jeon KO, Mills JJ, Bian Z, Sensintaffar JL, Arnold AL, Fogarty SA, Perry E, Ramsey HE, Cook R, Hollingshead M, Davis Millin M, Lee KM, Koss B, Budhraja A, Opferman JT, Kim K, Arteaga CL, Moore WJ, Olejniczak ET, Savona MR, Fesik SW. https://pubs.acs.org/doi/10.1021/acs.jmedchem.8b01991

Structural insights into BCL2 pro-survival protein interactions with the key autophagy regulator BECN1 following phosphorylation by STK4/MST1 – Erinna F. Lee, Nicholas A. Smith, Tatiana P. Soares da Costa, Nastaran Meftahi, Shenggen Yao, Tiffany J. Harris, Sharon Tran, Anne Pettikiriarachchi, Matthew A. Perugini, David W. Keizer, Marco Evangelista, Brian J. Smith and W. Douglas Fairlie. https://www.tandfonline.com/doi/full/10.1080/15548627.2018.1564557

Avoiding adsorption of Bcl-2 proteins to plasticware is important for accurate quantitation – Colin Hockings, Sweta Iyer, Rachel T. Uren and Ruth M. Kluck. https://www.nature.com/articles/s41418-019-0284-y

Interactions between cancer-associated fibroblasts and tumor cells promote MCL-1 dependency in estrogen receptor-positive breast cancers – Louault, T. L Bonneaud, C. Séveno, P. Gomez-Bougie, F. Nguyen, F. Gautier, N. Bourgeois, D. Loussouarn, O. Kerdraon, S. Barillé-Nion, P. Jézéquel, M. Campone, M. Amiot, P. P. Juin and F. Souazé. https://www.nature.com/articles/s41388-018-0635-z

Death receptors

T cells genetically engineered to overcome death signaling enhance adoptive cancer immunotherapy – Tori N. Yamamoto, Ping-Hsien Lee, Suman K. Vodnala, Devikala Gurusamy, Rigel J. Kishton, Zhiya Yu, Arash Eidizadeh, Robert Eil, Jessica Fioravanti, Luca Gattinoni, James N. Kochenderfer, Terry J. Fry, Bulent Arman Aksoy, Jeffrey E. Hammerbacher, Anthony C. Cruz, Richard M. Siegel, Nicholas P. Restifo and Christopher A. Klebanoff. https://www.jci.org/articles/view/121491

Impact of p53 status on TRAIL-mediated apoptotic and non-apoptotic signaling in cancer cells – Anna Willms, Hella Schittek, Sascha Rahn, Justyna Sosna, Ufuk Mert, Dieter Adam, Anna Trauzold. https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0214847

Necroptosis, RIPK1

Direct Activation of Human MLKL by a Select Repertoire of Inositol Phosphate Metabolites – Dan E. McNamara, Cole M. Dovey, Andrew T. Hale, Giovanni Quarato, Christy R. Grace, Cristina D. Guibao, Jonathan Diep, Amanda Nourse, Casey R. Cai, Hong Wu, Ravi C. Kalathur, Douglas R. Green, John D. York, Jan E. Carette, Tudor Moldoveanu. https://www.cell.com/cell-chemical-biology/fulltext/S2451-9456(19)30106-0

Serine 25 phosphorylation inhibits RIPK1 kinase-dependent cell death in models of infection and inflammation – Yves Dondelinger, Tom Delanghe, Dario Priem, Meghan A. Wynosky-Dolfi, Daniel Sorobetea, Diego Rojas-Rivera, Piero Giansanti, Ria Roelandt, Julia Gropengiesser, Klaus Ruckdeschel, Savvas N. Savvides, Albert J. R. Heck, Peter Vandenabeele, Igor E. Brodsky and Mathieu J. M. Bertrand. https://www.nature.com/articles/s41467-019-09690-0

RIPK1 prevents TRADD-driven, but TNFR1 independent, apoptosis during development – Holly Anderton, Esther Bandala-Sanchez, Daniel S Simpson, James A Rickard, Ashley P Ng, Ladina Di Rago, Cathrine Hall, James E Vince, John Silke, Gianmaria Liccardi and Rebecca Feltham. https://www.nature.com/articles/s41418-018-0166-8


A GPX4-dependent cancer cell state underlies the clear-cell morphology and confers sensitivity to ferroptosis – Yilong Zou, Michael J. Palte, Amy A. Deik, Haoxin Li, John K. Eaton, Wenyu Wang, Yuen-Yi Tseng, Rebecca Deasy, Maria Kost-Alimova, Vlado Dančík, Elizaveta S. Leshchiner, Vasanthi S. Viswanathan, Sabina Signoretti, Toni K. Choueiri, Jesse S. Boehm, Bridget K. Wagner, John G. Doench, Clary B. Clish, Paul A. Clemons and Stuart L. Schreiber. https://www.nature.com/articles/s41467-019-09277-9

The Deubiquitylase OTUB1 Mediates Ferroptosis via Stabilization of SLC7A11 – Tong Liu, Le Jiang, Omid Tavana and Wei Gu. http://cancerres.aacrjournals.org/content/79/8/1913

Mechanistic basis for impaired ferroptosis in cells expressing the African-centric S47 variant of p53 – Julia I-Ju Leu, Maureen E. Murphy and Donna L. George. https://www.pnas.org/content/116/17/8390.abstract?etoc


Lysosomal Machinery Drives Extracellular Acidification to Direct Non-apoptotic Cell Death [of the nurse cell] – Albert A. Mondragon, Alla Yalonetskaya, Anthony J. Ortega, Yuanhang Zhang, Oandy Naranjo, Johnny Elguero, Won-Suk Chung, Kimberly McCall. https://www.cell.com/cell-reports/fulltext/S2211-1247(19)30350-X?


Methods for monitoring the progression of cell death, cell disassembly and cell clearance – Lanzhou Jiang and Ivan K. H. Poon. https://link.springer.com/article/10.1007/s10495-018-01511-x

Navigating the Fas lane to improved cellular therapy for cancer – Madhav V. Dhodapkar. https://www.jci.org/articles/view/127581

MAVS‐induced mitochondrial membrane remodeling – Hector Flores‐Romero, Ana J. García‐Sáez. https://febs.onlinelibrary.wiley.com/doi/10.1111/febs.14822

DUBbing Ferroptosis in Cancer Cells – Boyi Gan. http://cancerres.aacrjournals.org/content/79/8/1749


September 22-25, 2019, Weizmann Institute of Science


ApoList – March 2019

Caspases, metacaspases and IAPs

Apoptotic Caspases Suppress Type I Interferon Production via the Cleavage of cGAS, MAVS, and IRF3 – Xiaohan Ning, Yutao Wang, Miao Jing, Mengyin Sha, Mengze Lv, P engfei Gao, Rui Zhang, Xiaojun Huang, Ji-Ming Feng, Zhengfan Jiang. https://www.cell.com/molecular-cell/fulltext/S1097-2765(19)30103-0

Damage on plants activates Ca2+-dependent metacaspases for release of immunomodulatory peptides – Tim Hander, Álvaro D. Fernández-Fernández, Robert P. Kumpf, Patrick Willems, Hendrik Schatowitz, Debbie Rombaut, An Staes, Jonah Nolf, Robin Pottie, Panfeng Yao, Amanda Gonçalves, Benjamin Pavie, Thomas Boller, Kris Gevaert, Frank Van Breusegem, Sebastian Bartels, Simon Stael. http://science.sciencemag.org/content/363/6433/eaar7486

The Caspase-3 homolog DrICE regulates endocytic trafficking during Drosophila tracheal morphogenesis – Saoirse S. McSharry and Greg J. Beitel. https://www.nature.com/articles/s41467-019-09009-z

The RING domain in the anti-apoptotic protein XIAP stabilizes c-Myc protein and preserves anchorage-independent growth of bladder cancer cells – Guosong Jiang, Chao Huang, Xin Liao, Jingxia Li, Xue-Ru Wu, Fuqing Zeng and Chuanshu Huang. http://www.jbc.org/content/early/2019/02/28/jbc.RA118.005621.abstract

Necroptosis, RIP kinases

RIPK1 can mediate apoptosis in addition to necroptosis during embryonic development – Xuhua Zhang, John P. Dowling and Jianke Zhang. https://www.nature.com/articles/s41419-019-1490-8

Identification of a novel class of RIP1/RIP3 dual inhibitors that impede cell death and inflammation in mouse abdominal aortic aneurysm models – Ting Zhou, Qiwei Wang, Noel Phan, Jun Ren, Huan Yang, Conner C. Feldman, John B. Feltenberger, Zhengqing Ye, Scott A. Wildman, Weiping Tang and Bo Liu. https://www.nature.com/articles/s41419-019-1468-6

O-GlcNAc Transferase Suppresses Inflammation and Necroptosis by Targeting Receptor-Interacting Serine/Threonine-Protein Kinase 3 – Xinghui Li, Wei Gong, Hao Wang, Tianliang Li, Kuldeep S. Attri, Robert E. Lewis, Andre C. Kalil, Fatema Bhinderwala, Robert Powers, Guowei Yin, Laura E. Herring, John M. Asara, Yu L. Lei, Xiaoyong Yang, Diego A. Rodriguez, Mao Yang, Douglas R. Green, Pankaj K. Singh, Haitao Wen. https://www.cell.com/immunity/fulltext/S1074-7613(19)30030-5

RIP1 kinase inhibitor halts the progression of an immune-induced demyelination disease at the stage of monocyte elevation – Sitao Zhang, Yaning Su, Zhengxin Ying, Dejia Guo, Chenjie Pan, Jia Guo, Ziye Zou, Lei Wang, Ze Zhang, Zhaodi Jiang, Zhiyuan Zhang and Xiaodong Wang. https://www.pnas.org/content/116/12/5675.abstract?etoc

Activated MLKL attenuates autophagy following its translocation to intracellular membranes – Daniel Frank, David L. Vaux, James M. Murphy, James E. Vince and Lisa M. Lindqvist. http://jcs.biologists.org/content/132/5/jcs220996?etoc

Other non-apoptotic forms of cell death

Entosis Controls a Developmental Cell Clearance in C. elegans – Yongchan Lee, Jens C. Hamann, Mark Pellegrino, Joanne Durgan, Marie-Charlotte Domart, Lucy M. Collinson, Cole M. Haynes, Oliver Florey, Michael Overholtzer. https://www.cell.com/cell-reports/fulltext/S2211-1247(19)30252-9

Drosophila p53 directs non-apoptotic programs in postmitotic tissue – Paula Kurtz, Amanda E. Jones, Bhavana Tiwari, Nichole Link, Annika Wylie, Charles Tracy, Helmut Krämer and John M. Abrams. https://www.molbiolcell.org/doi/abs/10.1091/mbc.E18-12-0791

A major role for ferroptosis in Mycobacterium tuberculosis–induced cell death and tissue necrosis – Eduardo P. Amaral, Diego L. Costa, Sivaranjani Namasivayam, Nicolas Riteau, Olena Kamenyeva, Lara Mittereder, Katrin D. Mayer-Barber, Bruno B. Andrade and Alan Sher. http://jem.rupress.org/content/216/3/556?etoc

Efferocytosis and cell-cell communication

Apoptotic tumor cell-derived microRNA-375 uses CD36 to alter the tumor-associated macrophage phenotype – Ann-Christin Frank, Stefanie Ebersberger, Annika F. Fink, Sebastian Lampe, Andreas Weigert, Tobias Schmid, Ingo Ebersberger, Shahzad Nawaz Syed and Bernhard Brüne. https://www.nature.com/articles/s41467-019-08989-2

Bcl-2 family proteins

A Phase Ib Dose-Escalation and Expansion Study of the BCL2 Inhibitor Venetoclax Combined with Tamoxifen in ER and BCL2–Positive Metastatic Breast Cancer – Sheau W. Lok, James R. Whittle, François Vaillant, Charis E. Teh, Louisa L. Lo, Antonia N. Policheni, Alice R.T. Bergin, Jayesh Desai, Sarah Ftouni, Luke C. Gandolfo, Danny Liew, He K. Liu, G. Bruce Mann, Kate Moodie, Anand Murugasu, Bhupinder Pal, Andrew W. Roberts, Mark A. Rosenthal, Kylie Shackleton, Maria João Silva, Zhen R. Siow, Gordon K. Smyth, Leanne Taylor, Avraham Travers, Belinda Yeo, Miriam M. Yeung, Andjelija Zivanovic Bujak, Sarah-Jane Dawson, Daniel H.D. Gray, Jane E. Visvader and Geoffrey J. Lindeman. http://cancerdiscovery.aacrjournals.org/content/9/3/354

Bim escapes displacement by BH3-mimetic anti-cancer drugs by double-bolt locking both Bcl-XL and Bcl-2 – Qian Liu, Elizabeth J Oesterlund, Xiaoke Chi, Justin Pogmore, Brian Leber, David William Andrews. https://elifesciences.org/articles/37689

Acquisition of the Recurrent Gly101Val Mutation in BCL2 Confers Resistance to Venetoclax in Patients with Progressive Chronic Lymphocytic Leukemia – Piers Blombery, Mary Ann Anderson, Jia-nan Gong, Rachel Thijssen, Richard W. Birkinshaw, Ella R. Thompson, Charis E. Teh, Tamia Nguyen, Zhen Xu, Christoffer Flensburg, Thomas E. Lew, Ian J. Majewski, Daniel H.D. Gray, David A. Westerman, Constantine S. Tam, John F. Seymour, Peter E. Czabotar, David C.S. Huang and Andrew W. Roberts. http://cancerdiscovery.aacrjournals.org/content/9/3/342

The Ewing Family of Tumors Relies on BCL-2 and BCL-XL to Escape PARP Inhibitor Toxicity – Daniel A.R. Heisey, Timothy L. Lochmann, Konstantinos V. Floros, Colin M. Coon, Krista M. Powell, Sheeba Jacob, Marissa L. Calbert, Maninderjit S. Ghotra, Giovanna T. Stein, Yuki Kato Maves, Steven C. Smith, Cyril H. Benes, Joel D. Leverson, Andrew J. Souers, Sosipatros A. Boikos and Anthony C. Faber. http://clincancerres.aacrjournals.org/content/25/5/1664

Retromer facilitates the localization of Bcl-xL to the mitochondrial outer membrane – Trey Farmer, Katelyn L. O’Neill, Naava Naslavsky, Xu Luo and Steve Caplan. https://www.molbiolcell.org/doi/10.1091/mbc.E19-01-0044?ai=25zg&ui=2oy6&af=T

Mitochondrial origins of fractional control in regulated cell death – Luís C. Santos, Robert Vogel, Jerry E. Chipuk, Marc R. Birtwistle, Gustavo Stolovitzky and Pablo Meyer. https://www.nature.com/articles/s41467-019-09275-x


MDM2 Integrates Cellular Respiration and Apoptotic Signaling through NDUFS1 and the Mitochondrial Network – Rana Elkholi, Ioana Abraham-Enachescu, Andrew P. Trotta, Camila Rubio-Patiño, Jarvier N. Mohammed, Mark P.A. Luna-Vargas, Jesse D. Gelles, Joshua R. Kaminetsky, Madhavika N. Serasinghe, Cindy Zou, Sumaira Ali, Gavin P. McStay, Cathie M. Pfleger, Jerry Edward Chipuk. https://www.cell.com/molecular-cell/fulltext/S1097-2765(19)30102-9

Ran1 is essential for parental macronuclear import of apoptosis‐inducing factor and programmed nuclear death in Tetrahymena thermophila – Haixia Liang, Jing Xu, Wei Wang. https://febs.onlinelibrary.wiley.com/doi/10.1111/febs.14761


Autophagy-dependent cell death – Donna Denton and Sharad Kumar. https://www.nature.com/articles/s41418-018-0252-y

Intersections between Regulated Cell Death and Autophagy – Francesco Napoletano, Olga Baron, Peter Vandenabeele, Bertrand Mollereau, Manolis Fanto. https://www.cell.com/trends/cell-biology/fulltext/S0962-8924(18)30237-X

LC3-associated phagocytosis at a glance – Bradlee L. Heckmann and Douglas R. Green. http://jcs.biologists.org/content/132/5/jcs222984?etoc

Enzymatically oxidized phospholipids assume center stage as essential regulators of innate immunity and cell death – Valerie B. O’Donnell , Maceler Aldrovandi, Robert C. Murphy, Gerhard Krönke. http://stke.sciencemag.org/content/12/574/eaau2293

Oxidative stress, eryptosis and anemia: a pivotal mechanistic nexus in systemic diseases – Rosi Bissinger, Abdulla Al Mamun Bhuyan, Syed M. Qadri, Florian Lang. https://febs.onlinelibrary.wiley.com/doi/10.1111/febs.14606

Comments / other

Cheating Death: New Molecules Block BAX – Loren D. Walensky. https://www.cell.com/trends/molecular-medicine/fulltext/S1471-4914(19)30043-7

The good, the bad and the autophagosome: exploring unanswered questions of autophagy-dependent cell death – Jurgen Kriel and Ben Loos. https://www.nature.com/articles/s41418-018-0267-4

Interview: a conversation with Vishva M Dixit on his journey from remote African village to apoptosis, necroptosis and the inflammasome – Vishva M. Dixit. https://www.nature.com/articles/s41418-019-0294-9?

Gly101Val BCL2 Mutation: One Step Closer to Understanding Venetoclax Resistance in CLL – Shanmugapriya Thangavadivel and John C. Byrd. http://cancerdiscovery.aacrjournals.org/content/9/3/320

Targeting Apoptosis: A New Paradigm for the Treatment of Estrogen Receptor–Positive Breast Cancer – Joshua Z. Drago, Sarat Chandarlapaty and Komal Jhaveri. http://cancerdiscovery.aacrjournals.org/content/9/3/323


EMBO Workshop: Cell death in immunity and inflammation

06 – 09 October 2019 | Crete, Greece. Organized by Manolis Pasparakis and Núria Sánchez-Coll


ApoList – February 2019

Bcl-2 family proteins

Small-molecule allosteric inhibitors of BAX – Thomas P. Garner, Dulguun Amgalan, Denis E. Reyna, Sheng Li, Richard N. Kitsis & Evripidis Gavathiotis. https://www.nature.com/articles/s41589-018-0223-0

Molecular and topological reorganizations in mitochondrial architecture interplay during Bax-mediated steps of apoptosis – Nicholas R Ader, Patrick C Hoffmann, Iva Ganeva, Alicia C Borgeaud, Chunxin Wang, Richard J Youle, Wanda Kukulski. https://elifesciences.org/articles/40712

Constitutive IP3 signaling underlies the sensitivity of B-cell cancers to the Bcl-2/IP3 receptor disruptor BIRD-2 – Mart Bittremieux, Rita M. La Rovere, Haidar Akl, Claudio Martines, Kirsten Welkenhuyzen, Kathia Dubron, Myriam Baes, Ann Janssens, Peter Vandenberghe, Luca Laurenti, Katja Rietdorf, Giampaolo Morciano, Paolo Pinton, Katsuhiko Mikoshiba, Martin D. Bootman, Dimitar G. Efremov, Humbert De Smedt, Jan B. Parys and Geert Bultynck. https://www.nature.com/articles/s41418-018-0142-3

Confounding off-target effects of BH3 mimetics at commonly used concentrations: MIM1, UMI-77, and A-1210477 – David J. Mallick, Ryan S. Soderquist, Darcy Bates and Alan Eastman. https://www.nature.com/articles/s41419-019-1426-3

Biomarker-driven strategy for MCL1 inhibition in T-cell lymphomas – Raphael Koch, Amanda L. Christie, Jennifer L. Crombie, Adam C. Palmer, Deborah Plana, Kay Shigemori, Sara N. Morrow, Alexandria Van Scoyk, Wenchao Wu, Elizabeth A. Brem, J. Paul Secrist, Lisa Drew, Alwin G. Schuller, Justin Cidado, Anthony Letai and David M. Weinstock. http://bloodjournal.org/content/133/6/566.abstract

MGMT-activated DUB3 stabilizes MCL1 and drives chemoresistance in ovarian cancer – Xiaowei Wu, Qingyu Luo, Pengfei Zhao, Wan Chang, Yating Wang, Tong Shu, Fang Ding, Bin Li, and Zhihua Liu. https://www.pnas.org/content/116/8/2961.abstract

LncRNA H19 overexpression induces bortezomib resistance in multiple myeloma by targeting MCL-1 via miR-29b-3p – Yafang Pan, Yu Zhang, Wenwen Liu, Yan Huang, Xianjuan Shen, Rongrong Jing, Jiang Pu, Xudong Wang, Shaoqing Ju, Hui Cong and Hongmei Chen. https://www.nature.com/articles/s41419-018-1219-0

Folding/unfolding kinetics of G-quadruplexes upstream of the P1 promoter of the human BCL-2 oncogene – Yuanlei Cheng, Qingnan Tang, Yutong Li, Yashuo Zhang, Chuyuan Zhao, Jie Yan and Huijuan You. http://www.jbc.org/content/early/2019/02/20/jbc.RA119.007516.abstract

The pro-apoptotic Bcl-2 family member Harakiri (HRK) induces cell death in glioblastoma multiforme – Ezgi Kaya-Aksoy, Ahmet Cingoz, Filiz Senbabaoglu, Fidan Seker, Ilknur Sur-Erdem, Alisan Kayabolen, Tolga Lokumcu, Gizem Nur Sahin, Sercin Karahuseyinoglu and Tugba Bagci-Onder. https://www.nature.com/articles/s41420-019-0144-z

Death receptors, FADD

Redundant and receptor-specific activities of TRADD, RIPK1 and FADD in death receptor signaling – Simone Füllsack, Alevtina Rosenthal, Harald Wajant and Daniela Siegmund. https://www.nature.com/articles/s41419-019-1396-5

TRADD regulates perinatal development and adulthood survival in mice lacking RIPK1 and RIPK3 – John P. Dowling, Mohamed Alsabbagh, Christina Del Casale, Zheng-Gang Liu and Jianke Zhang. https://www.nature.com/articles/s41467-019-08584-5

Engagement of Fas differentially regulates the production of LPS‐induced proinflammatory cytokines and type I interferons – Kiva Brennan, Caitriona Lyons, Philana Fernandes, Sarah Doyle, Aileen Houston, Elizabeth Brint. https://febs.onlinelibrary.wiley.com/doi/10.1111/febs.14727

The classical NLRP3 inflammasome controls FADD unconventional secretion through microvesicle shedding – Sara Mouasni, Virginie Gonzalez, Alain Schmitt, Evangeline Bennana, François Guillonneau. https://www.nature.com/articles/s41419-019-1412-9

Death receptor 5 is activated by fucosylation in colon cancer cells – Baojie Zhang, Ingrid A. M. van Roosmalen, Carlos R. Reis, Rita Setroikromo, Wim J. Quax. https://febs.onlinelibrary.wiley.com/doi/10.1111/febs.14742

Generation and characterization of novel anti-DR4 and anti-DR5 antibodies developed by genetic immunization – Agathe Dubuisson, Cécile Favreau, Eric Fourmaux, Sabrina Lareure, Rafael Rodrigues-Saraiva, Catherine Pellat-Deceunynck, Said El Alaoui and Olivier Micheau. https://www.nature.com/articles/s41419-019-1343-5

Tumor necrosis factor‐related apoptosis‐inducing ligand reduces the expression of the neuroprotective Na+/Ca2+ exchanger isoform NCX3 in human neuroblastoma SH‐SY5Y cells – Giulia Di Benedetto, Oriana Valerio, Vincenzo Lariccia, Chiara Burgaletto, Laurence Lempereur, Carmela Parenti, Guido Nicola Zanghì, Alessandra Matteucci, Salvatore Amoroso, Renato Bernardini, Giuseppina Cantarella. https://febs.onlinelibrary.wiley.com/doi/10.1111/febs.14732

The regulatory protein GADD34 inhibits TRAIL-induced apoptosis via TRAF6/ERK-dependent stabilization of myeloid cell leukemia 1 in liver cancer cells – Peiying Song, Songpeng Yang, Hui Hua, Hongying Zhang, Qingbin Kong, Jiao Wang, Ting Luo and Yangfu Jiang. http://www.jbc.org/content/early/2019/02/19/jbc.RA118.006029.abstract

Insights into ligand binding by a viral tumor necrosis factor (TNF) decoy receptor yield a selective soluble human type 2 TNF receptor – Sergio M. Pontejo, Carolina Sanchez, Begoña Ruiz-Argüello and Antonio Alcami. http://www.jbc.org/content/early/2019/02/05/jbc.RA118.005828.abstract

Absence of Cytosolic 2-Cys Prx Subtypes I and II Exacerbates TNF-α-Induced Apoptosis via Different Routes – Sunmi Lee, Joo Young Lee, Eun Woo Lee, Sujin Park, Dong Hoon Kang, Chengchun Min, Doo Jae Lee, Dongmin Kang, Jaewhan Song, Jongbum Kwon, Sang Won Kang. https://www.cell.com/cell-reports/fulltext/S2211-1247(19)30110-X

Disruption of the FasL/Fas axis protects against inflammation-derived tumorigenesis in chronic liver disease – Francisco Javier Cubero, Marius Maximilian Woitok, Miguel E. Zoubek, Alain de Bruin, Maximilian Hatting and Christian Trautwein. https://www.nature.com/articles/s41419-019-1391-x

Caspases and IAPs

RIPK1 and Caspase-8 Ensure Chromosome Stability Independently of Their Role in Cell Death and Inflammation – Gianmaria Liccardi, Laura Ramos Garcia, Tencho Tenev, Alessandro Annibaldi, Arnaud J. Legrand, David Robertson, Rebecca Feltham, Holly Anderton, Maurice Darding, Nieves Peltzer, Marius Dannappel, Hannah Schünke, Luca L. Fava, Manuel D. Haschka, Timo Glatter, Alexey Nesvizhskii, Alexander Schmidt, Philip A. Harris, John Bertin, Peter J. Gough, Andreas Villunger, John Silke, Manolis Pasparakis, Katiuscia Bianchi, Pascal Meier. https://www.cell.com/molecular-cell/fulltext/S1097-2765(18)30980-8

SERPINB1-mediated checkpoint of inflammatory caspase activation – Youn Jung Choi, Stephanie Kim, Younho Choi, Travis B. Nielsen, Jun Yan, Alvin Lu, Jianbin Ruan, Hye-Ra Lee, Hao Wu, Brad Spellberg and Jae U. Jung. https://www.nature.com/articles/s41590-018-0303-z

XIAP facilitates breast and colon carcinoma growth via promotion of p62 depletion through ubiquitination-dependent proteasomal degradation – Xing Huang, Xiao-nan Wang, Xiao-dong Yuan, Wen-yong Wu, Peter E. Lobie and Zhengsheng Wu. https://www.nature.com/articles/s41388-018-0513-8

Smac mimetic suppresses tunicamycin-induced apoptosis via resolution of ER stress – Behnaz Ahangarian Abhari, Nicole McCarthy, Marie Le Berre, Michelle Kilcoyne, Lokesh Joshi. https://www.nature.com/articles/s41419-019-1381-z

Necroptosis / ferroptosis

DNase II activated by the mitochondrial apoptotic pathway regulates RIP1-dependent non-apoptotic hepatocyte death via the TLR9/IFN-β signaling pathway – Yoshinobu Saito, Hayato Hikita, Yasutoshi Nozaki, Yugo Kai, Yuki Makino, Tasuku Nakabori, Satoshi Tanaka, Ryoko Yamada, Minoru Shigekawa, Takahiro Kodama, Ryotaro Sakamori, Tomohide Tatsumi and Tetsuo Takehara. https://www.nature.com/articles/s41418-018-0131-6

Necroptosis directly induces the release of full‐length biologically active IL‐33 in vitroand in an inflammatory disease model – Inbar Shlomovitz, Ziv Erlich, Mary Speir, Sefi Zargarian, Noam Baram, Maya Engler, Liat Edry‐Botzer, Ariel Munitz, Ben A. Croker, Motti Gerlic. https://febs.onlinelibrary.wiley.com/doi/10.1111/febs.14738

Chaperone-mediated autophagy is involved in the execution of ferroptosis – Zheming Wu, Yang Geng, Xiaojuan Lu, Yuying Shi, Guowei Wu, Mengmeng Zhang, Bing Shan, Heling Pan and Junying Yuan. https://www.pnas.org/content/116/8/2996.abstract

A Genome-wide Haploid Genetic Screen Identifies Regulators of Glutathione Abundance and Ferroptosis Sensitivity – Jennifer Yinuo Cao, Aunoy Poddar, Leslie Magtanong, Jennifer H. Lumb, Trevor R. Mileur, Michael A. Reid, Cole M. Dovey, Jin Wang, Jason W. Locasale, Everett Stone, Susan P.C. Cole, Jan E. Carette, Scott J. Dixon. https://www.cell.com/cell-reports/fulltext/S2211-1247(19)30061-0

Necroptosis in primate luteolysis: a role for ceramide – Konstantin Bagnjuk, Jan Bernd Stöckl, Thomas Fröhlich, Georg Josef Arnold, Rüdiger Behr, Dieter Berg, Lars Kunz, Cecily Bishop, Jing Xu and Artur Mayerhofer. https://www.nature.com/articles/s41420-019-0149-7

Ferroptosis as a target for protection against cardiomyopathy – Xuexian Fang, Hao Wang, Dan Han, Enjun Xie, Xiang Yang, Jiayu Wei, Shanshan Gu, Feng Gao, Nali Zhu, Xiangju Yin, Qi Cheng, Pan Zhang, Wei Dai, Jinghai Chen, Fuquan Yang, Huang-Tian Yang, Andreas Linkermann, Wei Gu, Junxia Min and Fudi Wang. https://www.pnas.org/content/116/7/2672.abstract?etoc


Dying Neurons Utilize Innate Immune Signaling to Prime Glia for Phagocytosis during Development – Colleen N. McLaughlin, Jahci J. Perry-Richardson, Jaeda C. Coutinho-Budd, Heather T. Broihier. https://www.cell.com/developmental-cell/fulltext/S1534-5807(18)31087-6

Three cell deaths and a funeral: macrophage clearance of cells undergoing distinct modes of cell death – Katharina Klöditz and Bengt Fadeel. https://www.nature.com/articles/s41420-019-0146-x

Calpain cleaves phospholipid flippase ATP8A1 during apoptosis inplatelets – Weidong Jing, Mehmet Yabas, Angelika Bröer, Lucy Coupland, Elizabeth E.Gardiner, Anselm Enders and Stefan Bröer. http://www.bloodadvances.org/content/3/3/219.abstract?etoc


Mechanisms of cell death induced by arginase and asparaginase in precursor B-cell lymphoblasts – Lucy E. Métayer, Richard D. Brown, Saskia Carlebur, G. A. Amos Burke and Guy C. Brown. https://link.springer.com/article/10.1007/s10495-018-1506-3

Increased mitochondrial respiration promotes survival from endoplasmic reticulum stress – Jeffrey Knupp, Peter Arvan and Amy Chang. https://www.nature.com/articles/s41418-018-0133-4


To the edge of cell death and back – Yi‐Nan Gong, Jeremy Chase Crawford, Bradlee L. Heckmann, Douglas R. Green. https://febs.onlinelibrary.wiley.com/doi/10.1111/febs.14714

BCL-2 family isoforms in apoptosis and cancer – Chloe F. A. Warren, Michelle W. Wong-Brown and Nikola A. Bowden. https://www.nature.com/articles/s41419-019-1407-6

Targeting intrinsic cell death pathways to control fungal pathogens – Author links open overlay panelMadhuraKulkarni, Zachary D.Stolp, J. MarieHardwick. https://www.sciencedirect.com/science/article/abs/pii/S0006295219300188

Cancer therapeutics based on BCL-2 functional conversion – Martin C. Pearce, Arnold C. Satterthwait, Xiao-kun Zhang and Siva Kumar Kolluri. https://link.springer.com/article/10.1007/s10495-018-1504-5

TAK1 mediates convergence of cellular signals for death and survival – Sabreena Aashaq, Asiya Batool and Khurshid I. Andrabi. https://link.springer.com/article/10.1007/s10495-018-1490-7


Paradoxical Puma Prohibits Pyruvate Pumps to Prime Pathology – Douglas R. Green. https://www.cell.com/cancer-cell/fulltext/S1535-6108(19)30050-9

Death Eaters Rely on Metabolic Signaling to Wield Anti-inflammatory Responses – Antonietta Pietrangelo, Mireille Ouimet. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(19)30010-5

ApoList – January 2019


Bcl-2 family proteins

Wild-Type p53 Promotes Cancer Metabolic Switch by Inducing PUMA-Dependent Suppression of Oxidative Phosphorylation – Jinchul Kim, Lili Yu, Wancheng Chen, Yanxia Xu, Meng Wu, Dilyana Todorova, Qingshuang Tang, Bingbing Feng, Lei Jiang, Jingjin He, Guihua Chen, Xuemei Fu, Yang Xu. https://www.cell.com/cancer-cell/fulltext/S1535-6108(18)30584-1

Parkin inhibits BAK and BAX apoptotic function by distinct mechanisms during mitophagy – Jonathan P Bernardini, Jason M Brouwer, Iris KL Tan, Jarrod J Sandow, Shuai Huang, Che A Stafford, Aleksandra Bankovacki, Christopher D Riffkin, Ahmad Z Wardak, Peter E Czabotar, Michael Lazarou and Grant Dewson. http://EMBOJ.embopress.org/content/38/2/e99916?etoc

BFL1 modulates apoptosis at the membrane level through a bifunctional and multimodal mechanism showing key differences with BCLXL – Hector Flores-Romero, Olatz Landeta, Begoña Ugarte-Uribe, Katia Cosentino, Miguel García-Porras, Ana J. García-Sáez and Gorka Basañez. https://www.nature.com/articles/s41418-018-0258-5

Sensitivity to splicing modulation of BCL2 family genes defines cancer therapeutic strategies for splicing modulators – Daniel Aird, Teng Teng, Chia-Ling Huang, Ermira Pazolli, Deepti Banka, Kahlin Cheung-Ong, Cheryl Eifert, Craig Furman, Zhenhua Jeremy Wu, Michael Seiler, Silvia Buonamici, Peter Fekkes, Craig Karr, James Palacino, Eunice Park, Peter G. Smith, Lihua Yu, Yoshiharu Mizui, Markus Warmuth, Agustin Chicas, Laura Corson and Ping Zhu. https://www.nature.com/articles/s41467-018-08150-5

A Mammalian Mitophagy Receptor, Bcl2-L-13, Recruits the ULK1 Complex to Induce Mitophagy – Tomokazu Murakawa, Koji Okamoto, Shigemiki Omiya, Manabu Taneike, Osamu Yamaguchi, Kinya Otsu. https://www.cell.com/cell-reports/fulltext/S2211-1247(18)31980-6

Functional profiling of venetoclax sensitivity can predict clinical response in multiple myeloma – Shannon M. Matulis, Vikas A. Gupta,  Paola Neri, Nizar J. Bahlis, Paulo Maciag, Joel D. Leverson, Leonard T. Heffner Jr., Sagar Lonial, Ajay K. Nooka, Jonathan L. Kaufman and Lawrence H. Boise. https://www.nature.com/articles/s41375-018-0374-8

Death receptors

STAT3 inhibition induces Bax-dependent apoptosis in liver tumor myeloid-derived suppressor cells – Prajna Guha, Jillian Gardell, Josephine Darpolor, Marissa Cunetta, Matthew Lima, George Miller, N. Joseph Espat, Richard P. Junghans and Steven C. Katz. https://www.nature.com/articles/s41388-018-0449-z

TRAIL inhibits RANK signaling and suppresses osteoclast activation via inhibiting lipid raft assembly and TRAF6 recruitment – Hsiu-Jung Liao, Hwei-Fang Tsai, Chien-Sheng Wu, I.-Tsu Chyuan & Ping-Ning Hsu. https://www.nature.com/articles/s41419-019-1353-3

TAK1 Prevents Endothelial Apoptosis and Maintains Vascular Integrity – Hisamichi Naito, Tomohiro Iba, Taku Wakabayashi, Ikue Tai-Nagara, Jun-ichi Suehiro, Weizhen Jia, Daisuke Eino, Susumu Sakimoto, Fumitaka Muramatsu, Hiroyasu Kidoya, Hiroyuki Sakurai, Takashi Satoh, Shizuo Akira, Yoshiaki Kubota, Nobuyuki Takakura. https://www.cell.com/developmental-cell/fulltext/S1534-5807(18)31035-9

Caspases and IAPs

Caspase selective reagents for diagnosing apoptotic mechanisms – Marcin Poreba, Katarzyna Groborz, Mario Navarro, Scott J. Snipas, Marcin Drag and Guy S. Salvesen. https://www.nature.com/articles/s41418-018-0110-y

Transcriptome profiling of caspase-2deficient EμMyc and Th-MYCN mouse tumors identifies distinct putative roles for caspase-2 in neuronal differentiation and immune signaling – Loretta Dorstyn, Emily Hackett-Jones, Andrej Nikolic, Murray D. Norris, Yoon Lim, John Toubia, Michelle Haber and Sharad Kumar. https://www.nature.com/articles/s41419-018-1296-0

The prodomain of caspase-3 regulates its own removal and caspase activation – Katelyn G. Ponder and Lawrence H. Boise. https://www.nature.com/articles/s41420-019-0142-1

The transcription factor SP3 drives TNF-α expression in response to Smac mimetics – Shawn T. Beug , Herman H. Cheung, Tarun Sanda, Martine St-Jean, Caroline E. Beauregard, Hapsatou Mamady, Stephen D. Baird, Eric C. LaCasse, Robert G. Korneluk. http://stke.sciencemag.org/content/12/566/eaat9563

Necroptosis and RIP kinases

The Nucleotide Sensor ZBP1 and Kinase RIPK3 Induce the Enzyme IRG1 to Promote an Antiviral Metabolic State in Neurons – Brian P. Daniels, Sigal B. Kofman, Julian R. Smith, Geoffrey T. Norris, Annelise G. Snyder, Joseph P. Kolb, Xia Gao, Jason W. Locasale, Jennifer Martinez, Michael Gale Jr., Yueh-Ming Loo, Andrew Oberst. https://www.cell.com/immunity/fulltext/S1074-7613(18)30525-9

Increased Ripk1-mediated bone marrow necroptosis leads to myelodysplasia and bone marrow failure in mice – Patrice N. Wagner, Qiong Shi, Christi T. Salisbury-Ruf, Jing Zou, Michael R. Savona, Yuri Fedoriw and Sandra S. Zinkel. http://bloodjournal.org/content/133/2/107.abstract?etoc

Receptor-interacting Ser/Thr kinase 1 (RIPK1) and myosin IIA–dependent ceramidosomes form membrane pores that mediate blebbing and necroptosis – Rose Nganga, Natalia Oleinik, Jisun Kim, Shanmugam Panneer Selvam, Ryan De Palma, Kristen A. Johnson, Rasesh Y. Parikh, Vamsi Gangaraju, Yuri Peterson, Mohammed Dany, Robert V. Stahelin, Christina Voelkel-Johnson, Zdzislaw M. Szulc, Erhard Bieberich and Besim Ogretmen. http://www.jbc.org/content/294/2/502.abstract.html

Human RIPK1 deficiency causes combined immunodeficiency and inflammatory bowel diseases – Yue Li, Marita Führer, Ehsan Bahrami, Piotr Socha, Maja Klaudel-Dreszler, Amira Bouzidi, Yanshan Liu, Anna S. Lehle, Thomas Magg, Sebastian Hollizeck, Meino Rohlfs, Raffaele Conca, Michael Field, Neil Warner, Slae Mordechai, Eyal Shteyer, Dan Turner, Rachida Boukari, Reda Belbouab, Christoph Walz, Moritz M. Gaidt, Veit Hornung, Bernd Baumann, Ulrich Pannicke, Eman Al Idrissi, Hamza Ali Alghamdi, Fernando E. Sepulveda, Marine Gil, Geneviève de Saint Basile, Manfred Hönig, Sibylle Koletzko, Aleixo M. Muise, Scott B. Snapper, Klaus Schwarz, Christoph Klein and Daniel Kotlarz. https://www.pnas.org/content/116/3/970.abstract?etoc

Depletion of RIPK1 in hepatocytes exacerbates liver damage in fulminant viral hepatitis – Muhammad Farooq, Aveline Filliol, Mélanie Simoes Eugénio, Claire Piquet-Pellorce, Sarah Dion, Céline Raguenes-Nicol, Aurélien Jan, Marie-Thérèse Dimanche-Boitrel, Jacques Le Seyec and Michel Samson. https://www.nature.com/articles/s41419-018-1277-3

Constitutive interferon signaling maintains critical threshold of MLKL expression to license necroptosis – Joseph Sarhan, Beiyun C. Liu, Hayley I. Muendlein, Chi G. Weindel, Irina Smirnova, Amy Y. Tang, Vladimir Ilyukha, Maxim Sorokin, Anton Buzdin, Katherine A. Fitzgerald and Alexander Poltorak. https://www.nature.com/articles/s41418-018-0122-7

Autophagic cell death / Ferroptosis

Autophagic cell death restricts chromosomal instability during replicative crisis – Joe Nassour, Robert Radford, Adriana Correia. https://www.nature.com/articles/s41586-019-0885-0

Role of Mitochondria in Ferroptosis – Minghui Gao, Junmei Yi, Jiajun Zhu, Alexander M. Minikes, Prashant Monian, Craig B. Thompson, Xuejun Jiang. https://www.cell.com/molecular-cell/fulltext/S1097-2765(18)30936-5

Exogenous Monounsaturated Fatty Acids Promote a Ferroptosis-Resistant Cell State – Leslie Magtanong, Pin-Joe Ko, Milton To, Daniel K. Nomura, James A. Olzmann, Scott J. Dixon. https://www.cell.com/cell-chemical-biology/pdf/S2451-9456(18)30438-0.pdf


Identification of a novel anoikis signalling pathway using the fungal virulence factor gliotoxin – Haun F, Neumann S, Peintner L, Wieland K, Habicht J, Schwan C, Østevold K, Koczorowska MM, Biniossek M, Kist M, Busch H, Boerries M, Davis RJ, Maurer U, Schilling O, Aktories K, Borner C. https://www.nature.com/articles/s41467-018-05850-w


Regulation of apoptosis in health and disease: the balancing act of BCL-2 family proteins – Rumani Singh, Anthony Letai & Kristopher Sarosiek. https://www.nature.com/articles/s41580-018-0089-8

RIP Kinases in Liver Cell Death, Inflammation and Cancer – Vangelis Kondylis, Manolis Pasparakis. https://www.cell.com/trends/molecular-medicine/fulltext/S1471-4914(18)30203-X

BCL2-Family Dysregulation in B-Cell Malignancies: From Gene Expression Regulation to a Targeted Therapy Biomarker – Benoît Tessoulin, Antonin Papin, Patricia Gomez-Bougie, Celine Bellanger, Martine Amiot, Catherine Pellat-Deceunynck and David Chiron. https://www.frontiersin.org/articles/10.3389/fonc.2018.00645/full

Tissue-specific regulation of cytochrome c by post-translational modifications: respiration, the mitochondrial membrane potential, ROS, and apoptosis – Hasini A. Kalpage, Viktoriia Bazylianska, Maurice A. Recanati, Alemu Fite, Jenney Liu, Junmei Wan, Nikhil Mantena, Moh H. Malek, Izabela Podgorski, Elizabeth I. Heath, Asmita Vaishnav, Brian F. Edwards, Lawrence I. Grossman, Thomas H. Sanderson, Icksoo Lee and Maik Hüttemann. https://www.fasebj.org/doi/abs/10.1096/fj.201801417R?ai=s4&ui=ly8&af=T

Cell death pathways in pathogenic trypanosomatids: lessons of (over)kill – Rubem Figueiredo Sadok Menna-Barreto. https://www.nature.com/articles/s41419-019-1370-2


BH3 mimetics: Weapons of cancer cell destruction – Tríona Ní Chonghaile. http://stm.sciencemag.org/content/11/475/eaaw5311

Think We Understand the Role of DRP1 in Mitochondrial Biology? Zinc Again! – Jerry Edward Chipuk. https://www.cell.com/molecular-cell/fulltext/S1097-2765(18)31100-6

Endothelial Cell Killing by TAK1 Inhibition: A Novel Anti-angiogenic Strategy in Cancer Therapy – Nieves Peltzer, Henning Walczak. https://www.cell.com/developmental-cell/fulltext/S1534-5807(19)30011-5

BID-ding on necroptosis in MDS – Ben A. Croker and Michelle A. Kelliher. http://www.bloodjournal.org/content/133/2/103

RIPK3: Beyond Necroptosis – Azia S. Evans, Carolyn B. Coyne. https://www.cell.com/immunity/fulltext/S1074-7613(18)30579-X

Defying Death: The (W)hole Truth about the Fate of GSDMD Pores – Charles L. Evavold, Jonathan C. Kagan. https://www.cell.com/immunity/fulltext/S1074-7613(18)30580-6

Profile of Hao Wu – Farooq Ahmed. https://www.pnas.org/content/116/4/1078?etoc=

Retrospective. Gordon Shore (1945 – 2018).http://www.asbmb.org/asbmbtoday/201901/Retrospective/Shore/#disqus_thread

Upcoming meetings

Genes and Cancer 2019 / 8 – 11 April 2019. Cambridge, UK,


2nd Cell Death, Cell Stress and Metabolism Conference / 27 May 2019 – 30 May 2019. Puerto Vallarta, México


Cold Spring Harbor Cell Death meeting / August 13 – 17, 2019


ApoList – December 2018


Multidomain Bcl-2 family proteins

Discovery of Mcl-1-specific inhibitor AZD5991 and preclinical activity in multiple myeloma and acute myeloid leukemia – Adriana E. Tron, Matthew A. Belmonte, Ammar Adam, Brian M. Aquila, Lawrence H. Boise, Elisabetta Chiarparin, Justin Cidado, Kevin J. Embrey, Eric Gangl, Francis D. Gibbons, Gareth P. Gregory, David Hargreaves, J. Adam Hendricks, Jeffrey W. Johannes, Ricky W. Johnstone, Steven L. Kazmirski, Jason G. Kettle, Michelle L. Lamb, Shannon M. Matulis, Ajay K. Nooka, Martin J. Packer, Bo Peng, Philip B. Rawlins, Daniel W. Robbins, Alwin G. Schuller, Nancy Su, Wenzhan Yang, Qing Ye, Xiaolan Zheng, J. Paul Secrist, Edwin A. Clark, David M. Wilson, Stephen E. Fawell and Alexander W. Hird. https://www.nature.com/articles/s41467-018-07551-w

Venetoclax combined with decitabine or azacitidine in treatment-naive, elderly patients with acute myeloid leukemia – Courtney D. DiNardo, Keith Pratz, Vinod Pullarkat, Brian A. Jonas, Martha Arellano, Pamela S. Becker, Olga Frankfurt, Marina Konopleva, Andrew H. Wei, Hagop M. Kantarjian, Tu Xu, Wan-Jen Hong, Brenda Chyla, Jalaja Potluri, Daniel A. Pollyea and Anthony Letai. http://bloodjournal.org/content/133/1/7.abstract?etoc

BH3-mimetic toolkit guides the respective use of BCL2 and MCL1 BH3-mimetics in myeloma treatment – Patricia Gomez-Bougie, Sophie Maiga, Benoît Tessoulin, Jessie Bourcier, Antoine Bonnet, Manuel S. Rodriguez, Steven Le Gouill, Cyrille Touzeau, Philippe Moreau, Catherine Pellat-Deceunynck and Martine Amiot. http://bloodjournal.org/content/132/25/2656.abstract?etoc

Genetic biomarkers predict response to dual BCL-2 and MCL-1 targeting in acute myeloid leukaemia cells – Martin Grundy, Sahana Balakrishnan, Matthew Fox, Claire H. Seedhouse and  Nigel H. Russell. http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=view&path[]=26540&path[]=82570

Variable BCL2/BCL2L1 ratio in multiple myeloma with t(11;14) – Alice Cleynen, Mehmet Samur, Aurore Perrot, Laure Buisson, Sabrina Maheo, Mariateresa Fulciniti, Michel Attal, Nikhil Munshi, Hervé Avet-Loiseau and Jill Corre. http://bloodjournal.org/content/132/26/2778?etoc

Targeting BCL-xL improves the efficacy of bromodomain and extra-terminal protein inhibitors in triple-negative breast cancer by eliciting the death of senescent cells – Sylvia S. Gayle, Jennifer M. Sahni, Bryan M. Webb, Kristen L. Weber-Bonk, Melyssa S. Shively, Raffaella Spina, Eli E. Bar, Matthew K. Summers and Ruth A. Keri. http://www.jbc.org/content/early/2018/11/27/jbc.RA118.004712.abstract

HOXC6 promotes cervical cancer progression via regulation of Bcl-2 – Yongsheng Wang, Cong Wang, Na Liu, Jun Hou, Wenjing Xiao and Hui Wang. https://www.fasebj.org/doi/abs/10.1096/fj.201801099RR?ai=ts&ui=ly8&af=T

NOTCH1 Represses MCL-1 Levels in GSI-resistant T-ALL, Making them Susceptible to ABT-263 – Anahita Dastur, AHyun Choi, Carlotta Costa, Xunqin Yin, August Williams, Joseph McClanaghan, Max Greenberg, Justine Roderick, Neha U. Patel, Jessica Boisvert, Ultan McDermott, Mathew J. Garnett, Jorge Almenara, Steven Grant, Kathryn Rizzo, Jeffrey A. Engelman, Michelle Kelliher, Anthony C. Faber and Cyril H. Benes. http://clincancerres.aacrjournals.org/content/25/1/31

Targeted inhibition of PI3Kα/δ is synergistic with BCL-2 blockade in genetically defined subtypes of DLBCL – Kamil Bojarczuk, Kirsty Wienand, Jeremy A. Ryan, Linfeng Chen, Mariana Villalobos-Ortiz, Elisa Mandato, Joanna Stachura, Anthony Letai, Lee N. Lawton, Bjoern Chapuy and Margaret A. Shipp. http://bloodjournal.org/content/133/1/70.abstract?etoc

BH3-only proteins

Spatiotemporal Control of CNS Myelination by Oligodendrocyte Programmed Cell Death through the TFEB-PUMA Axis – Lu O. Sun, Sara B. Mulinyawe, Hannah Y. Collins, Adiljan Ibrahim, Qingyun Li, David J. Simon, Marc Tessier-Lavigne, Ben A. Barres. https://www.cell.com/cell/fulltext/S0092-8674(18)31400-4?dgcid=raven_jbs_etoc_email

Lymphocyte-Specific Chromatin Accessibility Pre-determines Glucocorticoid Resistance in Acute Lymphoblastic Leukemia [Bim] – Duohui Jing, Yizhou Huang, Xiaoyun Liu, Keith C.S. Sia, Julia C. Zhang, Xiaolu Tai, Meng Wang, Cara E. Toscan, Hannah McCalmont, Kathryn Evans, Chelsea Mayoh, Rebecca C. Poulos, Miriam Span, Jianqing Mi, Chao Zhang, Jason W.H. Wong, Dominik Beck, John E. Pimanda, Richard B. Lock. https://www.cell.com/cancer-cell/fulltext/S1535-6108(18)30523-3

Mouse ER+/PIK3CAH1047R breast cancers caused by exogenous estrogen are heterogeneously dependent on estrogen and undergo BIM-dependent apoptosis with BH3 and PI3K agents – Elias E. Stratikopoulos, Nicole Kiess, Matthias Szabolcs, Sarah Pegno, Cheung Kakit, Xuewei Wu, Poulikos I. Poulikakos, Pamela Cheung, Hank Schmidt and Ramon Parsons. https://www.nature.com/articles/s41388-018-0436-4?

Death receptors

Herpes simplex virus 1 ICP6 impedes TNF receptor 1-induced necrosome assembly during compartmentalization to detergent-resistant membrane vesicles – Mohammad Ali, Linda Roback and Edward S. Mocarski. http://www.jbc.org/content/early/2018/11/30/jbc.RA118.004651.abstract

Caspase-8 and FLIP

RIPK1 and Caspase-8 Ensure Chromosome Stability Independently of Their Role in Cell Death and Inflammation – Gianmaria Liccardi, Laura Ramos Garcia, Tencho Tenev, Alessandro Annibaldi, Arnaud J. Legrand, David Robertson, Rebecca Feltham, Holly Anderton, Maurice Darding, Nieves Peltzer, Marius Dannappel, Hannah Schünke, Luca L. Fava, Manuel D. Haschka, Timo Glatter, Alexey Nesvizhskii, Alexander Schmidt, Philip A. Harris, John Bertin, Peter J. Gough, Andreas Villunger, John Silke, Manolis Pasparakis, Katiuscia Bianchi, Pascal Meier. https://www.cell.com/molecular-cell/fulltext/S1097-2765(18)30980-8

Regulated proteolysis of p62/SQSTM1 enables differential control of autophagy and nutrient sensing – Julia Sanchez-Garrido, Vanessa Sancho-Shimizu and Avinash R. Shenoy. http://stke.sciencemag.org/content/11/559/eaat6903

TLR-stimulated IRAKM activates caspase-8 inflammasome in microglia and promotes neuroinflammation – Cun-Jin Zhang, Meiling Jiang, Hao Zhou, Weiwei Liu, Chenhui Wang, Zizhen Kang, Bing Han, Quanri Zhang, Xing Chen, Jianxin Xiao, Amanda Fisher, William J. Kaiser, Masanori A. Murayama, Yoichiro Iwakura, Ji Gao, Julie Carman, Ashok Dongre, George Dubyak, Derek W. Abbott, Fu-Dong Shi, Richard M. Ransohoff and Xiaoxia Li. https://www.jci.org/articles/view/121901

Induction of immunosuppressive functions and NF-κB by FLIP in monocytes – Alessandra Fiore, Stefano Ugel, Francesco De Sanctis, Sara Sandri, Giulio Fracasso, Rosalinda Trovato, Silvia Sartoris, Samantha Solito, Susanna Mandruzzato, Fulvia Vascotto, Keli L. Hippen, Giada Mondanelli, Ursula Grohmann, Geny Piro, Carmine Carbone, Davide Melisi, Rita T. Lawlor, Aldo Scarpa, Alessia Lamolinara, Manuela Iezzi, Matteo Fassan, Silvio Bicciato, Bruce R. Blazar, Ugur Sahin, Peter J. Murray and Vincenzo Bronte. https://www.nature.com/articles/s41467-018-07654-4


Single-cell analysis of pyroptosis dynamics reveals conserved GSDMD-mediated subcellular events that precede plasma membrane rupture – Nathalia M. de Vasconcelos, Nina Van Opdenbosch, Hanne Van Gorp, Eef Parthoens and Mohamed Lamkanfi. https://www.nature.com/articles/s41418-018-0106-7

Inflammation / Efferocytosis

Molecular mechanisms of biogenesis of apoptotic exosome-like vesicles and their roles as damage-associated molecular patterns – Soo Jeong Park, Jeong Mi Kim, Jihyo Kim, Jaehark Hur, Sun Park, Kyongmin Kim, Ho-Joon Shin and Yong-Joon Chwae. https://www.pnas.org/content/115/50/E11721?etoc=

Efferocytosis Fuels Requirements of Fatty Acid Oxidation and the Electron Transport Chain to Polarize Macrophages for Tissue Repair – Shuang Zhang, Samuel Weinberg, Matthew DeBerge, Anastasiia Gainullina, Matthew Schipma, Jason M. Kinchen, Issam Ben-Sahra, David R. Gius, Laurent Yvan- Charvet, Navdeep S. Chandel, Paul T. Schumacker, Edward B. Thorp. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(18)30741-1#%20

Treatment-Induced Tumor Cell Apoptosis and Secondary Necrosis Drive Tumor Progression in the Residual Tumor Microenvironment through MerTK and IDO1 – Thomas A. Werfel, David L. Elion, Bushra Rahman, Donna J. Hicks, Violeta Sanchez, Paula I. Gonzales-Ericsson, Mellissa J. Nixon, Jamaal L. James, Justin M. Balko, Peggy A. Scherle, Holly K. Koblish and Rebecca S. Cook. http://cancerres.aacrjournals.org/content/79/1/171


The SMAC mimetic LCL-161 displays antitumor activity in preclinical models of rituximab-resistant B-cell lymphoma – Kyle Runckel, Matthew J. Barth, Cory Mavis, Juan J. Gu and Francisco J. Hernandez-Ilizaliturri. http://www.bloodadvances.org/content/2/23/3516.abstract?etoc

Dimerization and auto-processing induce caspase-11 protease activation within the non-canonical inflammasome – Connie Ross, Amy H Chan, Jessica Von Pein, Dave Boucher and Kate Schroder. http://life-science-alliance.org/content/1/6/e201800237.abstract

ATP Synthase C-Subunit-Deficient Mitochondria Have a Small Cyclosporine A-Sensitive Channel, but Lack the Permeability Transition Pore – Maria A. Neginskaya, Maria E. Solesio, Elena V. Berezhnaya, Giuseppe F. Amodeo, Nelli Mnatsakanyan, Elizabeth A. Jonas, Evgeny V. Pavlov. https://www.cell.com/cell-reports/fulltext/S2211-1247(18)31963-6


BH3-Mimetic Drugs: Blazing the Trail for New Cancer Medicines – Delphine Merino, Gemma L. Kelly, Guillaume Lessene, Andrew H. Wei, Andrew W. Roberts, Andreas Strasser. https://www.cell.com/cancer-cell/fulltext/S1535-6108(18)30525-7

The Structural Basis of Necroptotic Cell Death Signaling – Emma J. Petrie, Peter E. Czabotar, James M. Murphy. https://www.cell.com/trends/biochemical-sciences/fulltext/S0968-0004(18)30229-9

Role and Regulation of Pro-survival BCL-2 Proteins in Multiple Myeloma – Anne Slomp and Victor Peperzak. https://www.frontiersin.org/articles/10.3389/fonc.2018.00533/full


Special issue on Necroinflammation



* Death and fire: the concept of necroinflammation – Andreas Linkermann

* Necroptosis in anti-viral inflammation – Himani Nailwal and Francis Ka-Ming Chan

* Ferroptosis and necroinflammation, a yet poorly explored link – Bettina Proneth and Marcus Conrad

* Programmed Necrosis and Disease:We interrupt your regular programming to bring you necroinflammation – Eui Ho Kim, Sing-Wai Wong and Jennifer Martinez

* Crashing the computer: apoptosis vs. necroptosis in neuroinflammation – Bradlee L. Heckmann, Bart Tummers and Douglas R. Green

* Necroinflammation emerges as a key regulator of hematopoiesis in health and disease – Philipp J. Jost and Ulrike Höckendorf

* Paving the way for precision medicine v2.0 in intensive care by profiling necroinflammation in biofluids – Tom Vanden Berghe and Eric Hoste

* Pyroptosis versus necroptosis: similarities, differences, and crosstalk – Daniel Frank and James E. Vince

* Comparing the effects of different cell death programs in tumor progression and immunotherapy – Michelle N. Messmer, Annelise G. Snyder and Andrew Oberst


Macrophages regulate the clearance of living cells by calreticulin – Dmitri V. Krysko, Kodi S. Ravichandran and Peter Vandenabeele. https://www.nature.com/articles/s41467-018-06807-9

Glucocorticoid Resistance in Acute Lymphoblastic Leukemia: BIM Finally – Jessie A. Brown, Adolfo Ferrando. https://www.cell.com/cancer-cell/fulltext/S1535-6108(18)30532-4

Venetoclax in AML: aiming for “just right” – Laura C. Michaelis. http://bloodjournal.org/content/133/1/3?etoc