ApoList – March 2019

Caspases, metacaspases and IAPs

Apoptotic Caspases Suppress Type I Interferon Production via the Cleavage of cGAS, MAVS, and IRF3 – Xiaohan Ning, Yutao Wang, Miao Jing, Mengyin Sha, Mengze Lv, P engfei Gao, Rui Zhang, Xiaojun Huang, Ji-Ming Feng, Zhengfan Jiang. https://www.cell.com/molecular-cell/fulltext/S1097-2765(19)30103-0

Damage on plants activates Ca2+-dependent metacaspases for release of immunomodulatory peptides – Tim Hander, Álvaro D. Fernández-Fernández, Robert P. Kumpf, Patrick Willems, Hendrik Schatowitz, Debbie Rombaut, An Staes, Jonah Nolf, Robin Pottie, Panfeng Yao, Amanda Gonçalves, Benjamin Pavie, Thomas Boller, Kris Gevaert, Frank Van Breusegem, Sebastian Bartels, Simon Stael. http://science.sciencemag.org/content/363/6433/eaar7486

The Caspase-3 homolog DrICE regulates endocytic trafficking during Drosophila tracheal morphogenesis – Saoirse S. McSharry and Greg J. Beitel. https://www.nature.com/articles/s41467-019-09009-z

The RING domain in the anti-apoptotic protein XIAP stabilizes c-Myc protein and preserves anchorage-independent growth of bladder cancer cells – Guosong Jiang, Chao Huang, Xin Liao, Jingxia Li, Xue-Ru Wu, Fuqing Zeng and Chuanshu Huang. http://www.jbc.org/content/early/2019/02/28/jbc.RA118.005621.abstract

Necroptosis, RIP kinases

RIPK1 can mediate apoptosis in addition to necroptosis during embryonic development – Xuhua Zhang, John P. Dowling and Jianke Zhang. https://www.nature.com/articles/s41419-019-1490-8

Identification of a novel class of RIP1/RIP3 dual inhibitors that impede cell death and inflammation in mouse abdominal aortic aneurysm models – Ting Zhou, Qiwei Wang, Noel Phan, Jun Ren, Huan Yang, Conner C. Feldman, John B. Feltenberger, Zhengqing Ye, Scott A. Wildman, Weiping Tang and Bo Liu. https://www.nature.com/articles/s41419-019-1468-6

O-GlcNAc Transferase Suppresses Inflammation and Necroptosis by Targeting Receptor-Interacting Serine/Threonine-Protein Kinase 3 – Xinghui Li, Wei Gong, Hao Wang, Tianliang Li, Kuldeep S. Attri, Robert E. Lewis, Andre C. Kalil, Fatema Bhinderwala, Robert Powers, Guowei Yin, Laura E. Herring, John M. Asara, Yu L. Lei, Xiaoyong Yang, Diego A. Rodriguez, Mao Yang, Douglas R. Green, Pankaj K. Singh, Haitao Wen. https://www.cell.com/immunity/fulltext/S1074-7613(19)30030-5

RIP1 kinase inhibitor halts the progression of an immune-induced demyelination disease at the stage of monocyte elevation – Sitao Zhang, Yaning Su, Zhengxin Ying, Dejia Guo, Chenjie Pan, Jia Guo, Ziye Zou, Lei Wang, Ze Zhang, Zhaodi Jiang, Zhiyuan Zhang and Xiaodong Wang. https://www.pnas.org/content/116/12/5675.abstract?etoc

Activated MLKL attenuates autophagy following its translocation to intracellular membranes – Daniel Frank, David L. Vaux, James M. Murphy, James E. Vince and Lisa M. Lindqvist. http://jcs.biologists.org/content/132/5/jcs220996?etoc

Other non-apoptotic forms of cell death

Entosis Controls a Developmental Cell Clearance in C. elegans – Yongchan Lee, Jens C. Hamann, Mark Pellegrino, Joanne Durgan, Marie-Charlotte Domart, Lucy M. Collinson, Cole M. Haynes, Oliver Florey, Michael Overholtzer. https://www.cell.com/cell-reports/fulltext/S2211-1247(19)30252-9

Drosophila p53 directs non-apoptotic programs in postmitotic tissue – Paula Kurtz, Amanda E. Jones, Bhavana Tiwari, Nichole Link, Annika Wylie, Charles Tracy, Helmut Krämer and John M. Abrams. https://www.molbiolcell.org/doi/abs/10.1091/mbc.E18-12-0791

A major role for ferroptosis in Mycobacterium tuberculosis–induced cell death and tissue necrosis – Eduardo P. Amaral, Diego L. Costa, Sivaranjani Namasivayam, Nicolas Riteau, Olena Kamenyeva, Lara Mittereder, Katrin D. Mayer-Barber, Bruno B. Andrade and Alan Sher. http://jem.rupress.org/content/216/3/556?etoc

Efferocytosis and cell-cell communication

Apoptotic tumor cell-derived microRNA-375 uses CD36 to alter the tumor-associated macrophage phenotype – Ann-Christin Frank, Stefanie Ebersberger, Annika F. Fink, Sebastian Lampe, Andreas Weigert, Tobias Schmid, Ingo Ebersberger, Shahzad Nawaz Syed and Bernhard Brüne. https://www.nature.com/articles/s41467-019-08989-2

Bcl-2 family proteins

A Phase Ib Dose-Escalation and Expansion Study of the BCL2 Inhibitor Venetoclax Combined with Tamoxifen in ER and BCL2–Positive Metastatic Breast Cancer – Sheau W. Lok, James R. Whittle, François Vaillant, Charis E. Teh, Louisa L. Lo, Antonia N. Policheni, Alice R.T. Bergin, Jayesh Desai, Sarah Ftouni, Luke C. Gandolfo, Danny Liew, He K. Liu, G. Bruce Mann, Kate Moodie, Anand Murugasu, Bhupinder Pal, Andrew W. Roberts, Mark A. Rosenthal, Kylie Shackleton, Maria João Silva, Zhen R. Siow, Gordon K. Smyth, Leanne Taylor, Avraham Travers, Belinda Yeo, Miriam M. Yeung, Andjelija Zivanovic Bujak, Sarah-Jane Dawson, Daniel H.D. Gray, Jane E. Visvader and Geoffrey J. Lindeman. http://cancerdiscovery.aacrjournals.org/content/9/3/354

Bim escapes displacement by BH3-mimetic anti-cancer drugs by double-bolt locking both Bcl-XL and Bcl-2 – Qian Liu, Elizabeth J Oesterlund, Xiaoke Chi, Justin Pogmore, Brian Leber, David William Andrews. https://elifesciences.org/articles/37689

Acquisition of the Recurrent Gly101Val Mutation in BCL2 Confers Resistance to Venetoclax in Patients with Progressive Chronic Lymphocytic Leukemia – Piers Blombery, Mary Ann Anderson, Jia-nan Gong, Rachel Thijssen, Richard W. Birkinshaw, Ella R. Thompson, Charis E. Teh, Tamia Nguyen, Zhen Xu, Christoffer Flensburg, Thomas E. Lew, Ian J. Majewski, Daniel H.D. Gray, David A. Westerman, Constantine S. Tam, John F. Seymour, Peter E. Czabotar, David C.S. Huang and Andrew W. Roberts. http://cancerdiscovery.aacrjournals.org/content/9/3/342

The Ewing Family of Tumors Relies on BCL-2 and BCL-XL to Escape PARP Inhibitor Toxicity – Daniel A.R. Heisey, Timothy L. Lochmann, Konstantinos V. Floros, Colin M. Coon, Krista M. Powell, Sheeba Jacob, Marissa L. Calbert, Maninderjit S. Ghotra, Giovanna T. Stein, Yuki Kato Maves, Steven C. Smith, Cyril H. Benes, Joel D. Leverson, Andrew J. Souers, Sosipatros A. Boikos and Anthony C. Faber. http://clincancerres.aacrjournals.org/content/25/5/1664

Retromer facilitates the localization of Bcl-xL to the mitochondrial outer membrane – Trey Farmer, Katelyn L. O’Neill, Naava Naslavsky, Xu Luo and Steve Caplan. https://www.molbiolcell.org/doi/10.1091/mbc.E19-01-0044?ai=25zg&ui=2oy6&af=T

Mitochondrial origins of fractional control in regulated cell death – Luís C. Santos, Robert Vogel, Jerry E. Chipuk, Marc R. Birtwistle, Gustavo Stolovitzky and Pablo Meyer. https://www.nature.com/articles/s41467-019-09275-x


MDM2 Integrates Cellular Respiration and Apoptotic Signaling through NDUFS1 and the Mitochondrial Network – Rana Elkholi, Ioana Abraham-Enachescu, Andrew P. Trotta, Camila Rubio-Patiño, Jarvier N. Mohammed, Mark P.A. Luna-Vargas, Jesse D. Gelles, Joshua R. Kaminetsky, Madhavika N. Serasinghe, Cindy Zou, Sumaira Ali, Gavin P. McStay, Cathie M. Pfleger, Jerry Edward Chipuk. https://www.cell.com/molecular-cell/fulltext/S1097-2765(19)30102-9

Ran1 is essential for parental macronuclear import of apoptosis‐inducing factor and programmed nuclear death in Tetrahymena thermophila – Haixia Liang, Jing Xu, Wei Wang. https://febs.onlinelibrary.wiley.com/doi/10.1111/febs.14761


Autophagy-dependent cell death – Donna Denton and Sharad Kumar. https://www.nature.com/articles/s41418-018-0252-y

Intersections between Regulated Cell Death and Autophagy – Francesco Napoletano, Olga Baron, Peter Vandenabeele, Bertrand Mollereau, Manolis Fanto. https://www.cell.com/trends/cell-biology/fulltext/S0962-8924(18)30237-X

LC3-associated phagocytosis at a glance – Bradlee L. Heckmann and Douglas R. Green. http://jcs.biologists.org/content/132/5/jcs222984?etoc

Enzymatically oxidized phospholipids assume center stage as essential regulators of innate immunity and cell death – Valerie B. O’Donnell , Maceler Aldrovandi, Robert C. Murphy, Gerhard Krönke. http://stke.sciencemag.org/content/12/574/eaau2293

Oxidative stress, eryptosis and anemia: a pivotal mechanistic nexus in systemic diseases – Rosi Bissinger, Abdulla Al Mamun Bhuyan, Syed M. Qadri, Florian Lang. https://febs.onlinelibrary.wiley.com/doi/10.1111/febs.14606

Comments / other

Cheating Death: New Molecules Block BAX – Loren D. Walensky. https://www.cell.com/trends/molecular-medicine/fulltext/S1471-4914(19)30043-7

The good, the bad and the autophagosome: exploring unanswered questions of autophagy-dependent cell death – Jurgen Kriel and Ben Loos. https://www.nature.com/articles/s41418-018-0267-4

Interview: a conversation with Vishva M Dixit on his journey from remote African village to apoptosis, necroptosis and the inflammasome – Vishva M. Dixit. https://www.nature.com/articles/s41418-019-0294-9?

Gly101Val BCL2 Mutation: One Step Closer to Understanding Venetoclax Resistance in CLL – Shanmugapriya Thangavadivel and John C. Byrd. http://cancerdiscovery.aacrjournals.org/content/9/3/320

Targeting Apoptosis: A New Paradigm for the Treatment of Estrogen Receptor–Positive Breast Cancer – Joshua Z. Drago, Sarat Chandarlapaty and Komal Jhaveri. http://cancerdiscovery.aacrjournals.org/content/9/3/323


EMBO Workshop: Cell death in immunity and inflammation

06 – 09 October 2019 | Crete, Greece. Organized by Manolis Pasparakis and Núria Sánchez-Coll



ApoList – February 2019

Bcl-2 family proteins

Small-molecule allosteric inhibitors of BAX – Thomas P. Garner, Dulguun Amgalan, Denis E. Reyna, Sheng Li, Richard N. Kitsis & Evripidis Gavathiotis. https://www.nature.com/articles/s41589-018-0223-0

Molecular and topological reorganizations in mitochondrial architecture interplay during Bax-mediated steps of apoptosis – Nicholas R Ader, Patrick C Hoffmann, Iva Ganeva, Alicia C Borgeaud, Chunxin Wang, Richard J Youle, Wanda Kukulski. https://elifesciences.org/articles/40712

Constitutive IP3 signaling underlies the sensitivity of B-cell cancers to the Bcl-2/IP3 receptor disruptor BIRD-2 – Mart Bittremieux, Rita M. La Rovere, Haidar Akl, Claudio Martines, Kirsten Welkenhuyzen, Kathia Dubron, Myriam Baes, Ann Janssens, Peter Vandenberghe, Luca Laurenti, Katja Rietdorf, Giampaolo Morciano, Paolo Pinton, Katsuhiko Mikoshiba, Martin D. Bootman, Dimitar G. Efremov, Humbert De Smedt, Jan B. Parys and Geert Bultynck. https://www.nature.com/articles/s41418-018-0142-3

Confounding off-target effects of BH3 mimetics at commonly used concentrations: MIM1, UMI-77, and A-1210477 – David J. Mallick, Ryan S. Soderquist, Darcy Bates and Alan Eastman. https://www.nature.com/articles/s41419-019-1426-3

Biomarker-driven strategy for MCL1 inhibition in T-cell lymphomas – Raphael Koch, Amanda L. Christie, Jennifer L. Crombie, Adam C. Palmer, Deborah Plana, Kay Shigemori, Sara N. Morrow, Alexandria Van Scoyk, Wenchao Wu, Elizabeth A. Brem, J. Paul Secrist, Lisa Drew, Alwin G. Schuller, Justin Cidado, Anthony Letai and David M. Weinstock. http://bloodjournal.org/content/133/6/566.abstract

MGMT-activated DUB3 stabilizes MCL1 and drives chemoresistance in ovarian cancer – Xiaowei Wu, Qingyu Luo, Pengfei Zhao, Wan Chang, Yating Wang, Tong Shu, Fang Ding, Bin Li, and Zhihua Liu. https://www.pnas.org/content/116/8/2961.abstract

LncRNA H19 overexpression induces bortezomib resistance in multiple myeloma by targeting MCL-1 via miR-29b-3p – Yafang Pan, Yu Zhang, Wenwen Liu, Yan Huang, Xianjuan Shen, Rongrong Jing, Jiang Pu, Xudong Wang, Shaoqing Ju, Hui Cong and Hongmei Chen. https://www.nature.com/articles/s41419-018-1219-0

Folding/unfolding kinetics of G-quadruplexes upstream of the P1 promoter of the human BCL-2 oncogene – Yuanlei Cheng, Qingnan Tang, Yutong Li, Yashuo Zhang, Chuyuan Zhao, Jie Yan and Huijuan You. http://www.jbc.org/content/early/2019/02/20/jbc.RA119.007516.abstract

The pro-apoptotic Bcl-2 family member Harakiri (HRK) induces cell death in glioblastoma multiforme – Ezgi Kaya-Aksoy, Ahmet Cingoz, Filiz Senbabaoglu, Fidan Seker, Ilknur Sur-Erdem, Alisan Kayabolen, Tolga Lokumcu, Gizem Nur Sahin, Sercin Karahuseyinoglu and Tugba Bagci-Onder. https://www.nature.com/articles/s41420-019-0144-z

Death receptors, FADD

Redundant and receptor-specific activities of TRADD, RIPK1 and FADD in death receptor signaling – Simone Füllsack, Alevtina Rosenthal, Harald Wajant and Daniela Siegmund. https://www.nature.com/articles/s41419-019-1396-5

TRADD regulates perinatal development and adulthood survival in mice lacking RIPK1 and RIPK3 – John P. Dowling, Mohamed Alsabbagh, Christina Del Casale, Zheng-Gang Liu and Jianke Zhang. https://www.nature.com/articles/s41467-019-08584-5

Engagement of Fas differentially regulates the production of LPS‐induced proinflammatory cytokines and type I interferons – Kiva Brennan, Caitriona Lyons, Philana Fernandes, Sarah Doyle, Aileen Houston, Elizabeth Brint. https://febs.onlinelibrary.wiley.com/doi/10.1111/febs.14727

The classical NLRP3 inflammasome controls FADD unconventional secretion through microvesicle shedding – Sara Mouasni, Virginie Gonzalez, Alain Schmitt, Evangeline Bennana, François Guillonneau. https://www.nature.com/articles/s41419-019-1412-9

Death receptor 5 is activated by fucosylation in colon cancer cells – Baojie Zhang, Ingrid A. M. van Roosmalen, Carlos R. Reis, Rita Setroikromo, Wim J. Quax. https://febs.onlinelibrary.wiley.com/doi/10.1111/febs.14742

Generation and characterization of novel anti-DR4 and anti-DR5 antibodies developed by genetic immunization – Agathe Dubuisson, Cécile Favreau, Eric Fourmaux, Sabrina Lareure, Rafael Rodrigues-Saraiva, Catherine Pellat-Deceunynck, Said El Alaoui and Olivier Micheau. https://www.nature.com/articles/s41419-019-1343-5

Tumor necrosis factor‐related apoptosis‐inducing ligand reduces the expression of the neuroprotective Na+/Ca2+ exchanger isoform NCX3 in human neuroblastoma SH‐SY5Y cells – Giulia Di Benedetto, Oriana Valerio, Vincenzo Lariccia, Chiara Burgaletto, Laurence Lempereur, Carmela Parenti, Guido Nicola Zanghì, Alessandra Matteucci, Salvatore Amoroso, Renato Bernardini, Giuseppina Cantarella. https://febs.onlinelibrary.wiley.com/doi/10.1111/febs.14732

The regulatory protein GADD34 inhibits TRAIL-induced apoptosis via TRAF6/ERK-dependent stabilization of myeloid cell leukemia 1 in liver cancer cells – Peiying Song, Songpeng Yang, Hui Hua, Hongying Zhang, Qingbin Kong, Jiao Wang, Ting Luo and Yangfu Jiang. http://www.jbc.org/content/early/2019/02/19/jbc.RA118.006029.abstract

Insights into ligand binding by a viral tumor necrosis factor (TNF) decoy receptor yield a selective soluble human type 2 TNF receptor – Sergio M. Pontejo, Carolina Sanchez, Begoña Ruiz-Argüello and Antonio Alcami. http://www.jbc.org/content/early/2019/02/05/jbc.RA118.005828.abstract

Absence of Cytosolic 2-Cys Prx Subtypes I and II Exacerbates TNF-α-Induced Apoptosis via Different Routes – Sunmi Lee, Joo Young Lee, Eun Woo Lee, Sujin Park, Dong Hoon Kang, Chengchun Min, Doo Jae Lee, Dongmin Kang, Jaewhan Song, Jongbum Kwon, Sang Won Kang. https://www.cell.com/cell-reports/fulltext/S2211-1247(19)30110-X

Disruption of the FasL/Fas axis protects against inflammation-derived tumorigenesis in chronic liver disease – Francisco Javier Cubero, Marius Maximilian Woitok, Miguel E. Zoubek, Alain de Bruin, Maximilian Hatting and Christian Trautwein. https://www.nature.com/articles/s41419-019-1391-x

Caspases and IAPs

RIPK1 and Caspase-8 Ensure Chromosome Stability Independently of Their Role in Cell Death and Inflammation – Gianmaria Liccardi, Laura Ramos Garcia, Tencho Tenev, Alessandro Annibaldi, Arnaud J. Legrand, David Robertson, Rebecca Feltham, Holly Anderton, Maurice Darding, Nieves Peltzer, Marius Dannappel, Hannah Schünke, Luca L. Fava, Manuel D. Haschka, Timo Glatter, Alexey Nesvizhskii, Alexander Schmidt, Philip A. Harris, John Bertin, Peter J. Gough, Andreas Villunger, John Silke, Manolis Pasparakis, Katiuscia Bianchi, Pascal Meier. https://www.cell.com/molecular-cell/fulltext/S1097-2765(18)30980-8

SERPINB1-mediated checkpoint of inflammatory caspase activation – Youn Jung Choi, Stephanie Kim, Younho Choi, Travis B. Nielsen, Jun Yan, Alvin Lu, Jianbin Ruan, Hye-Ra Lee, Hao Wu, Brad Spellberg and Jae U. Jung. https://www.nature.com/articles/s41590-018-0303-z

XIAP facilitates breast and colon carcinoma growth via promotion of p62 depletion through ubiquitination-dependent proteasomal degradation – Xing Huang, Xiao-nan Wang, Xiao-dong Yuan, Wen-yong Wu, Peter E. Lobie and Zhengsheng Wu. https://www.nature.com/articles/s41388-018-0513-8

Smac mimetic suppresses tunicamycin-induced apoptosis via resolution of ER stress – Behnaz Ahangarian Abhari, Nicole McCarthy, Marie Le Berre, Michelle Kilcoyne, Lokesh Joshi. https://www.nature.com/articles/s41419-019-1381-z

Necroptosis / ferroptosis

DNase II activated by the mitochondrial apoptotic pathway regulates RIP1-dependent non-apoptotic hepatocyte death via the TLR9/IFN-β signaling pathway – Yoshinobu Saito, Hayato Hikita, Yasutoshi Nozaki, Yugo Kai, Yuki Makino, Tasuku Nakabori, Satoshi Tanaka, Ryoko Yamada, Minoru Shigekawa, Takahiro Kodama, Ryotaro Sakamori, Tomohide Tatsumi and Tetsuo Takehara. https://www.nature.com/articles/s41418-018-0131-6

Necroptosis directly induces the release of full‐length biologically active IL‐33 in vitroand in an inflammatory disease model – Inbar Shlomovitz, Ziv Erlich, Mary Speir, Sefi Zargarian, Noam Baram, Maya Engler, Liat Edry‐Botzer, Ariel Munitz, Ben A. Croker, Motti Gerlic. https://febs.onlinelibrary.wiley.com/doi/10.1111/febs.14738

Chaperone-mediated autophagy is involved in the execution of ferroptosis – Zheming Wu, Yang Geng, Xiaojuan Lu, Yuying Shi, Guowei Wu, Mengmeng Zhang, Bing Shan, Heling Pan and Junying Yuan. https://www.pnas.org/content/116/8/2996.abstract

A Genome-wide Haploid Genetic Screen Identifies Regulators of Glutathione Abundance and Ferroptosis Sensitivity – Jennifer Yinuo Cao, Aunoy Poddar, Leslie Magtanong, Jennifer H. Lumb, Trevor R. Mileur, Michael A. Reid, Cole M. Dovey, Jin Wang, Jason W. Locasale, Everett Stone, Susan P.C. Cole, Jan E. Carette, Scott J. Dixon. https://www.cell.com/cell-reports/fulltext/S2211-1247(19)30061-0

Necroptosis in primate luteolysis: a role for ceramide – Konstantin Bagnjuk, Jan Bernd Stöckl, Thomas Fröhlich, Georg Josef Arnold, Rüdiger Behr, Dieter Berg, Lars Kunz, Cecily Bishop, Jing Xu and Artur Mayerhofer. https://www.nature.com/articles/s41420-019-0149-7

Ferroptosis as a target for protection against cardiomyopathy – Xuexian Fang, Hao Wang, Dan Han, Enjun Xie, Xiang Yang, Jiayu Wei, Shanshan Gu, Feng Gao, Nali Zhu, Xiangju Yin, Qi Cheng, Pan Zhang, Wei Dai, Jinghai Chen, Fuquan Yang, Huang-Tian Yang, Andreas Linkermann, Wei Gu, Junxia Min and Fudi Wang. https://www.pnas.org/content/116/7/2672.abstract?etoc


Dying Neurons Utilize Innate Immune Signaling to Prime Glia for Phagocytosis during Development – Colleen N. McLaughlin, Jahci J. Perry-Richardson, Jaeda C. Coutinho-Budd, Heather T. Broihier. https://www.cell.com/developmental-cell/fulltext/S1534-5807(18)31087-6

Three cell deaths and a funeral: macrophage clearance of cells undergoing distinct modes of cell death – Katharina Klöditz and Bengt Fadeel. https://www.nature.com/articles/s41420-019-0146-x

Calpain cleaves phospholipid flippase ATP8A1 during apoptosis inplatelets – Weidong Jing, Mehmet Yabas, Angelika Bröer, Lucy Coupland, Elizabeth E.Gardiner, Anselm Enders and Stefan Bröer. http://www.bloodadvances.org/content/3/3/219.abstract?etoc


Mechanisms of cell death induced by arginase and asparaginase in precursor B-cell lymphoblasts – Lucy E. Métayer, Richard D. Brown, Saskia Carlebur, G. A. Amos Burke and Guy C. Brown. https://link.springer.com/article/10.1007/s10495-018-1506-3

Increased mitochondrial respiration promotes survival from endoplasmic reticulum stress – Jeffrey Knupp, Peter Arvan and Amy Chang. https://www.nature.com/articles/s41418-018-0133-4


To the edge of cell death and back – Yi‐Nan Gong, Jeremy Chase Crawford, Bradlee L. Heckmann, Douglas R. Green. https://febs.onlinelibrary.wiley.com/doi/10.1111/febs.14714

BCL-2 family isoforms in apoptosis and cancer – Chloe F. A. Warren, Michelle W. Wong-Brown and Nikola A. Bowden. https://www.nature.com/articles/s41419-019-1407-6

Targeting intrinsic cell death pathways to control fungal pathogens – Author links open overlay panelMadhuraKulkarni, Zachary D.Stolp, J. MarieHardwick. https://www.sciencedirect.com/science/article/abs/pii/S0006295219300188

Cancer therapeutics based on BCL-2 functional conversion – Martin C. Pearce, Arnold C. Satterthwait, Xiao-kun Zhang and Siva Kumar Kolluri. https://link.springer.com/article/10.1007/s10495-018-1504-5

TAK1 mediates convergence of cellular signals for death and survival – Sabreena Aashaq, Asiya Batool and Khurshid I. Andrabi. https://link.springer.com/article/10.1007/s10495-018-1490-7


Paradoxical Puma Prohibits Pyruvate Pumps to Prime Pathology – Douglas R. Green. https://www.cell.com/cancer-cell/fulltext/S1535-6108(19)30050-9

Death Eaters Rely on Metabolic Signaling to Wield Anti-inflammatory Responses – Antonietta Pietrangelo, Mireille Ouimet. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(19)30010-5

ApoList – January 2019


Bcl-2 family proteins

Wild-Type p53 Promotes Cancer Metabolic Switch by Inducing PUMA-Dependent Suppression of Oxidative Phosphorylation – Jinchul Kim, Lili Yu, Wancheng Chen, Yanxia Xu, Meng Wu, Dilyana Todorova, Qingshuang Tang, Bingbing Feng, Lei Jiang, Jingjin He, Guihua Chen, Xuemei Fu, Yang Xu. https://www.cell.com/cancer-cell/fulltext/S1535-6108(18)30584-1

Parkin inhibits BAK and BAX apoptotic function by distinct mechanisms during mitophagy – Jonathan P Bernardini, Jason M Brouwer, Iris KL Tan, Jarrod J Sandow, Shuai Huang, Che A Stafford, Aleksandra Bankovacki, Christopher D Riffkin, Ahmad Z Wardak, Peter E Czabotar, Michael Lazarou and Grant Dewson. http://EMBOJ.embopress.org/content/38/2/e99916?etoc

BFL1 modulates apoptosis at the membrane level through a bifunctional and multimodal mechanism showing key differences with BCLXL – Hector Flores-Romero, Olatz Landeta, Begoña Ugarte-Uribe, Katia Cosentino, Miguel García-Porras, Ana J. García-Sáez and Gorka Basañez. https://www.nature.com/articles/s41418-018-0258-5

Sensitivity to splicing modulation of BCL2 family genes defines cancer therapeutic strategies for splicing modulators – Daniel Aird, Teng Teng, Chia-Ling Huang, Ermira Pazolli, Deepti Banka, Kahlin Cheung-Ong, Cheryl Eifert, Craig Furman, Zhenhua Jeremy Wu, Michael Seiler, Silvia Buonamici, Peter Fekkes, Craig Karr, James Palacino, Eunice Park, Peter G. Smith, Lihua Yu, Yoshiharu Mizui, Markus Warmuth, Agustin Chicas, Laura Corson and Ping Zhu. https://www.nature.com/articles/s41467-018-08150-5

A Mammalian Mitophagy Receptor, Bcl2-L-13, Recruits the ULK1 Complex to Induce Mitophagy – Tomokazu Murakawa, Koji Okamoto, Shigemiki Omiya, Manabu Taneike, Osamu Yamaguchi, Kinya Otsu. https://www.cell.com/cell-reports/fulltext/S2211-1247(18)31980-6

Functional profiling of venetoclax sensitivity can predict clinical response in multiple myeloma – Shannon M. Matulis, Vikas A. Gupta,  Paola Neri, Nizar J. Bahlis, Paulo Maciag, Joel D. Leverson, Leonard T. Heffner Jr., Sagar Lonial, Ajay K. Nooka, Jonathan L. Kaufman and Lawrence H. Boise. https://www.nature.com/articles/s41375-018-0374-8

Death receptors

STAT3 inhibition induces Bax-dependent apoptosis in liver tumor myeloid-derived suppressor cells – Prajna Guha, Jillian Gardell, Josephine Darpolor, Marissa Cunetta, Matthew Lima, George Miller, N. Joseph Espat, Richard P. Junghans and Steven C. Katz. https://www.nature.com/articles/s41388-018-0449-z

TRAIL inhibits RANK signaling and suppresses osteoclast activation via inhibiting lipid raft assembly and TRAF6 recruitment – Hsiu-Jung Liao, Hwei-Fang Tsai, Chien-Sheng Wu, I.-Tsu Chyuan & Ping-Ning Hsu. https://www.nature.com/articles/s41419-019-1353-3

TAK1 Prevents Endothelial Apoptosis and Maintains Vascular Integrity – Hisamichi Naito, Tomohiro Iba, Taku Wakabayashi, Ikue Tai-Nagara, Jun-ichi Suehiro, Weizhen Jia, Daisuke Eino, Susumu Sakimoto, Fumitaka Muramatsu, Hiroyasu Kidoya, Hiroyuki Sakurai, Takashi Satoh, Shizuo Akira, Yoshiaki Kubota, Nobuyuki Takakura. https://www.cell.com/developmental-cell/fulltext/S1534-5807(18)31035-9

Caspases and IAPs

Caspase selective reagents for diagnosing apoptotic mechanisms – Marcin Poreba, Katarzyna Groborz, Mario Navarro, Scott J. Snipas, Marcin Drag and Guy S. Salvesen. https://www.nature.com/articles/s41418-018-0110-y

Transcriptome profiling of caspase-2deficient EμMyc and Th-MYCN mouse tumors identifies distinct putative roles for caspase-2 in neuronal differentiation and immune signaling – Loretta Dorstyn, Emily Hackett-Jones, Andrej Nikolic, Murray D. Norris, Yoon Lim, John Toubia, Michelle Haber and Sharad Kumar. https://www.nature.com/articles/s41419-018-1296-0

The prodomain of caspase-3 regulates its own removal and caspase activation – Katelyn G. Ponder and Lawrence H. Boise. https://www.nature.com/articles/s41420-019-0142-1

The transcription factor SP3 drives TNF-α expression in response to Smac mimetics – Shawn T. Beug , Herman H. Cheung, Tarun Sanda, Martine St-Jean, Caroline E. Beauregard, Hapsatou Mamady, Stephen D. Baird, Eric C. LaCasse, Robert G. Korneluk. http://stke.sciencemag.org/content/12/566/eaat9563

Necroptosis and RIP kinases

The Nucleotide Sensor ZBP1 and Kinase RIPK3 Induce the Enzyme IRG1 to Promote an Antiviral Metabolic State in Neurons – Brian P. Daniels, Sigal B. Kofman, Julian R. Smith, Geoffrey T. Norris, Annelise G. Snyder, Joseph P. Kolb, Xia Gao, Jason W. Locasale, Jennifer Martinez, Michael Gale Jr., Yueh-Ming Loo, Andrew Oberst. https://www.cell.com/immunity/fulltext/S1074-7613(18)30525-9

Increased Ripk1-mediated bone marrow necroptosis leads to myelodysplasia and bone marrow failure in mice – Patrice N. Wagner, Qiong Shi, Christi T. Salisbury-Ruf, Jing Zou, Michael R. Savona, Yuri Fedoriw and Sandra S. Zinkel. http://bloodjournal.org/content/133/2/107.abstract?etoc

Receptor-interacting Ser/Thr kinase 1 (RIPK1) and myosin IIA–dependent ceramidosomes form membrane pores that mediate blebbing and necroptosis – Rose Nganga, Natalia Oleinik, Jisun Kim, Shanmugam Panneer Selvam, Ryan De Palma, Kristen A. Johnson, Rasesh Y. Parikh, Vamsi Gangaraju, Yuri Peterson, Mohammed Dany, Robert V. Stahelin, Christina Voelkel-Johnson, Zdzislaw M. Szulc, Erhard Bieberich and Besim Ogretmen. http://www.jbc.org/content/294/2/502.abstract.html

Human RIPK1 deficiency causes combined immunodeficiency and inflammatory bowel diseases – Yue Li, Marita Führer, Ehsan Bahrami, Piotr Socha, Maja Klaudel-Dreszler, Amira Bouzidi, Yanshan Liu, Anna S. Lehle, Thomas Magg, Sebastian Hollizeck, Meino Rohlfs, Raffaele Conca, Michael Field, Neil Warner, Slae Mordechai, Eyal Shteyer, Dan Turner, Rachida Boukari, Reda Belbouab, Christoph Walz, Moritz M. Gaidt, Veit Hornung, Bernd Baumann, Ulrich Pannicke, Eman Al Idrissi, Hamza Ali Alghamdi, Fernando E. Sepulveda, Marine Gil, Geneviève de Saint Basile, Manfred Hönig, Sibylle Koletzko, Aleixo M. Muise, Scott B. Snapper, Klaus Schwarz, Christoph Klein and Daniel Kotlarz. https://www.pnas.org/content/116/3/970.abstract?etoc

Depletion of RIPK1 in hepatocytes exacerbates liver damage in fulminant viral hepatitis – Muhammad Farooq, Aveline Filliol, Mélanie Simoes Eugénio, Claire Piquet-Pellorce, Sarah Dion, Céline Raguenes-Nicol, Aurélien Jan, Marie-Thérèse Dimanche-Boitrel, Jacques Le Seyec and Michel Samson. https://www.nature.com/articles/s41419-018-1277-3

Constitutive interferon signaling maintains critical threshold of MLKL expression to license necroptosis – Joseph Sarhan, Beiyun C. Liu, Hayley I. Muendlein, Chi G. Weindel, Irina Smirnova, Amy Y. Tang, Vladimir Ilyukha, Maxim Sorokin, Anton Buzdin, Katherine A. Fitzgerald and Alexander Poltorak. https://www.nature.com/articles/s41418-018-0122-7

Autophagic cell death / Ferroptosis

Autophagic cell death restricts chromosomal instability during replicative crisis – Joe Nassour, Robert Radford, Adriana Correia. https://www.nature.com/articles/s41586-019-0885-0

Role of Mitochondria in Ferroptosis – Minghui Gao, Junmei Yi, Jiajun Zhu, Alexander M. Minikes, Prashant Monian, Craig B. Thompson, Xuejun Jiang. https://www.cell.com/molecular-cell/fulltext/S1097-2765(18)30936-5

Exogenous Monounsaturated Fatty Acids Promote a Ferroptosis-Resistant Cell State – Leslie Magtanong, Pin-Joe Ko, Milton To, Daniel K. Nomura, James A. Olzmann, Scott J. Dixon. https://www.cell.com/cell-chemical-biology/pdf/S2451-9456(18)30438-0.pdf


Identification of a novel anoikis signalling pathway using the fungal virulence factor gliotoxin – Haun F, Neumann S, Peintner L, Wieland K, Habicht J, Schwan C, Østevold K, Koczorowska MM, Biniossek M, Kist M, Busch H, Boerries M, Davis RJ, Maurer U, Schilling O, Aktories K, Borner C. https://www.nature.com/articles/s41467-018-05850-w


Regulation of apoptosis in health and disease: the balancing act of BCL-2 family proteins – Rumani Singh, Anthony Letai & Kristopher Sarosiek. https://www.nature.com/articles/s41580-018-0089-8

RIP Kinases in Liver Cell Death, Inflammation and Cancer – Vangelis Kondylis, Manolis Pasparakis. https://www.cell.com/trends/molecular-medicine/fulltext/S1471-4914(18)30203-X

BCL2-Family Dysregulation in B-Cell Malignancies: From Gene Expression Regulation to a Targeted Therapy Biomarker – Benoît Tessoulin, Antonin Papin, Patricia Gomez-Bougie, Celine Bellanger, Martine Amiot, Catherine Pellat-Deceunynck and David Chiron. https://www.frontiersin.org/articles/10.3389/fonc.2018.00645/full

Tissue-specific regulation of cytochrome c by post-translational modifications: respiration, the mitochondrial membrane potential, ROS, and apoptosis – Hasini A. Kalpage, Viktoriia Bazylianska, Maurice A. Recanati, Alemu Fite, Jenney Liu, Junmei Wan, Nikhil Mantena, Moh H. Malek, Izabela Podgorski, Elizabeth I. Heath, Asmita Vaishnav, Brian F. Edwards, Lawrence I. Grossman, Thomas H. Sanderson, Icksoo Lee and Maik Hüttemann. https://www.fasebj.org/doi/abs/10.1096/fj.201801417R?ai=s4&ui=ly8&af=T

Cell death pathways in pathogenic trypanosomatids: lessons of (over)kill – Rubem Figueiredo Sadok Menna-Barreto. https://www.nature.com/articles/s41419-019-1370-2


BH3 mimetics: Weapons of cancer cell destruction – Tríona Ní Chonghaile. http://stm.sciencemag.org/content/11/475/eaaw5311

Think We Understand the Role of DRP1 in Mitochondrial Biology? Zinc Again! – Jerry Edward Chipuk. https://www.cell.com/molecular-cell/fulltext/S1097-2765(18)31100-6

Endothelial Cell Killing by TAK1 Inhibition: A Novel Anti-angiogenic Strategy in Cancer Therapy – Nieves Peltzer, Henning Walczak. https://www.cell.com/developmental-cell/fulltext/S1534-5807(19)30011-5

BID-ding on necroptosis in MDS – Ben A. Croker and Michelle A. Kelliher. http://www.bloodjournal.org/content/133/2/103

RIPK3: Beyond Necroptosis – Azia S. Evans, Carolyn B. Coyne. https://www.cell.com/immunity/fulltext/S1074-7613(18)30579-X

Defying Death: The (W)hole Truth about the Fate of GSDMD Pores – Charles L. Evavold, Jonathan C. Kagan. https://www.cell.com/immunity/fulltext/S1074-7613(18)30580-6

Profile of Hao Wu – Farooq Ahmed. https://www.pnas.org/content/116/4/1078?etoc=

Retrospective. Gordon Shore (1945 – 2018).http://www.asbmb.org/asbmbtoday/201901/Retrospective/Shore/#disqus_thread

Upcoming meetings

Genes and Cancer 2019 / 8 – 11 April 2019. Cambridge, UK,


2nd Cell Death, Cell Stress and Metabolism Conference / 27 May 2019 – 30 May 2019. Puerto Vallarta, México


Cold Spring Harbor Cell Death meeting / August 13 – 17, 2019


ApoList – December 2018


Multidomain Bcl-2 family proteins

Discovery of Mcl-1-specific inhibitor AZD5991 and preclinical activity in multiple myeloma and acute myeloid leukemia – Adriana E. Tron, Matthew A. Belmonte, Ammar Adam, Brian M. Aquila, Lawrence H. Boise, Elisabetta Chiarparin, Justin Cidado, Kevin J. Embrey, Eric Gangl, Francis D. Gibbons, Gareth P. Gregory, David Hargreaves, J. Adam Hendricks, Jeffrey W. Johannes, Ricky W. Johnstone, Steven L. Kazmirski, Jason G. Kettle, Michelle L. Lamb, Shannon M. Matulis, Ajay K. Nooka, Martin J. Packer, Bo Peng, Philip B. Rawlins, Daniel W. Robbins, Alwin G. Schuller, Nancy Su, Wenzhan Yang, Qing Ye, Xiaolan Zheng, J. Paul Secrist, Edwin A. Clark, David M. Wilson, Stephen E. Fawell and Alexander W. Hird. https://www.nature.com/articles/s41467-018-07551-w

Venetoclax combined with decitabine or azacitidine in treatment-naive, elderly patients with acute myeloid leukemia – Courtney D. DiNardo, Keith Pratz, Vinod Pullarkat, Brian A. Jonas, Martha Arellano, Pamela S. Becker, Olga Frankfurt, Marina Konopleva, Andrew H. Wei, Hagop M. Kantarjian, Tu Xu, Wan-Jen Hong, Brenda Chyla, Jalaja Potluri, Daniel A. Pollyea and Anthony Letai. http://bloodjournal.org/content/133/1/7.abstract?etoc

BH3-mimetic toolkit guides the respective use of BCL2 and MCL1 BH3-mimetics in myeloma treatment – Patricia Gomez-Bougie, Sophie Maiga, Benoît Tessoulin, Jessie Bourcier, Antoine Bonnet, Manuel S. Rodriguez, Steven Le Gouill, Cyrille Touzeau, Philippe Moreau, Catherine Pellat-Deceunynck and Martine Amiot. http://bloodjournal.org/content/132/25/2656.abstract?etoc

Genetic biomarkers predict response to dual BCL-2 and MCL-1 targeting in acute myeloid leukaemia cells – Martin Grundy, Sahana Balakrishnan, Matthew Fox, Claire H. Seedhouse and  Nigel H. Russell. http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=view&path[]=26540&path[]=82570

Variable BCL2/BCL2L1 ratio in multiple myeloma with t(11;14) – Alice Cleynen, Mehmet Samur, Aurore Perrot, Laure Buisson, Sabrina Maheo, Mariateresa Fulciniti, Michel Attal, Nikhil Munshi, Hervé Avet-Loiseau and Jill Corre. http://bloodjournal.org/content/132/26/2778?etoc

Targeting BCL-xL improves the efficacy of bromodomain and extra-terminal protein inhibitors in triple-negative breast cancer by eliciting the death of senescent cells – Sylvia S. Gayle, Jennifer M. Sahni, Bryan M. Webb, Kristen L. Weber-Bonk, Melyssa S. Shively, Raffaella Spina, Eli E. Bar, Matthew K. Summers and Ruth A. Keri. http://www.jbc.org/content/early/2018/11/27/jbc.RA118.004712.abstract

HOXC6 promotes cervical cancer progression via regulation of Bcl-2 – Yongsheng Wang, Cong Wang, Na Liu, Jun Hou, Wenjing Xiao and Hui Wang. https://www.fasebj.org/doi/abs/10.1096/fj.201801099RR?ai=ts&ui=ly8&af=T

NOTCH1 Represses MCL-1 Levels in GSI-resistant T-ALL, Making them Susceptible to ABT-263 – Anahita Dastur, AHyun Choi, Carlotta Costa, Xunqin Yin, August Williams, Joseph McClanaghan, Max Greenberg, Justine Roderick, Neha U. Patel, Jessica Boisvert, Ultan McDermott, Mathew J. Garnett, Jorge Almenara, Steven Grant, Kathryn Rizzo, Jeffrey A. Engelman, Michelle Kelliher, Anthony C. Faber and Cyril H. Benes. http://clincancerres.aacrjournals.org/content/25/1/31

Targeted inhibition of PI3Kα/δ is synergistic with BCL-2 blockade in genetically defined subtypes of DLBCL – Kamil Bojarczuk, Kirsty Wienand, Jeremy A. Ryan, Linfeng Chen, Mariana Villalobos-Ortiz, Elisa Mandato, Joanna Stachura, Anthony Letai, Lee N. Lawton, Bjoern Chapuy and Margaret A. Shipp. http://bloodjournal.org/content/133/1/70.abstract?etoc

BH3-only proteins

Spatiotemporal Control of CNS Myelination by Oligodendrocyte Programmed Cell Death through the TFEB-PUMA Axis – Lu O. Sun, Sara B. Mulinyawe, Hannah Y. Collins, Adiljan Ibrahim, Qingyun Li, David J. Simon, Marc Tessier-Lavigne, Ben A. Barres. https://www.cell.com/cell/fulltext/S0092-8674(18)31400-4?dgcid=raven_jbs_etoc_email

Lymphocyte-Specific Chromatin Accessibility Pre-determines Glucocorticoid Resistance in Acute Lymphoblastic Leukemia [Bim] – Duohui Jing, Yizhou Huang, Xiaoyun Liu, Keith C.S. Sia, Julia C. Zhang, Xiaolu Tai, Meng Wang, Cara E. Toscan, Hannah McCalmont, Kathryn Evans, Chelsea Mayoh, Rebecca C. Poulos, Miriam Span, Jianqing Mi, Chao Zhang, Jason W.H. Wong, Dominik Beck, John E. Pimanda, Richard B. Lock. https://www.cell.com/cancer-cell/fulltext/S1535-6108(18)30523-3

Mouse ER+/PIK3CAH1047R breast cancers caused by exogenous estrogen are heterogeneously dependent on estrogen and undergo BIM-dependent apoptosis with BH3 and PI3K agents – Elias E. Stratikopoulos, Nicole Kiess, Matthias Szabolcs, Sarah Pegno, Cheung Kakit, Xuewei Wu, Poulikos I. Poulikakos, Pamela Cheung, Hank Schmidt and Ramon Parsons. https://www.nature.com/articles/s41388-018-0436-4?

Death receptors

Herpes simplex virus 1 ICP6 impedes TNF receptor 1-induced necrosome assembly during compartmentalization to detergent-resistant membrane vesicles – Mohammad Ali, Linda Roback and Edward S. Mocarski. http://www.jbc.org/content/early/2018/11/30/jbc.RA118.004651.abstract

Caspase-8 and FLIP

RIPK1 and Caspase-8 Ensure Chromosome Stability Independently of Their Role in Cell Death and Inflammation – Gianmaria Liccardi, Laura Ramos Garcia, Tencho Tenev, Alessandro Annibaldi, Arnaud J. Legrand, David Robertson, Rebecca Feltham, Holly Anderton, Maurice Darding, Nieves Peltzer, Marius Dannappel, Hannah Schünke, Luca L. Fava, Manuel D. Haschka, Timo Glatter, Alexey Nesvizhskii, Alexander Schmidt, Philip A. Harris, John Bertin, Peter J. Gough, Andreas Villunger, John Silke, Manolis Pasparakis, Katiuscia Bianchi, Pascal Meier. https://www.cell.com/molecular-cell/fulltext/S1097-2765(18)30980-8

Regulated proteolysis of p62/SQSTM1 enables differential control of autophagy and nutrient sensing – Julia Sanchez-Garrido, Vanessa Sancho-Shimizu and Avinash R. Shenoy. http://stke.sciencemag.org/content/11/559/eaat6903

TLR-stimulated IRAKM activates caspase-8 inflammasome in microglia and promotes neuroinflammation – Cun-Jin Zhang, Meiling Jiang, Hao Zhou, Weiwei Liu, Chenhui Wang, Zizhen Kang, Bing Han, Quanri Zhang, Xing Chen, Jianxin Xiao, Amanda Fisher, William J. Kaiser, Masanori A. Murayama, Yoichiro Iwakura, Ji Gao, Julie Carman, Ashok Dongre, George Dubyak, Derek W. Abbott, Fu-Dong Shi, Richard M. Ransohoff and Xiaoxia Li. https://www.jci.org/articles/view/121901

Induction of immunosuppressive functions and NF-κB by FLIP in monocytes – Alessandra Fiore, Stefano Ugel, Francesco De Sanctis, Sara Sandri, Giulio Fracasso, Rosalinda Trovato, Silvia Sartoris, Samantha Solito, Susanna Mandruzzato, Fulvia Vascotto, Keli L. Hippen, Giada Mondanelli, Ursula Grohmann, Geny Piro, Carmine Carbone, Davide Melisi, Rita T. Lawlor, Aldo Scarpa, Alessia Lamolinara, Manuela Iezzi, Matteo Fassan, Silvio Bicciato, Bruce R. Blazar, Ugur Sahin, Peter J. Murray and Vincenzo Bronte. https://www.nature.com/articles/s41467-018-07654-4


Single-cell analysis of pyroptosis dynamics reveals conserved GSDMD-mediated subcellular events that precede plasma membrane rupture – Nathalia M. de Vasconcelos, Nina Van Opdenbosch, Hanne Van Gorp, Eef Parthoens and Mohamed Lamkanfi. https://www.nature.com/articles/s41418-018-0106-7

Inflammation / Efferocytosis

Molecular mechanisms of biogenesis of apoptotic exosome-like vesicles and their roles as damage-associated molecular patterns – Soo Jeong Park, Jeong Mi Kim, Jihyo Kim, Jaehark Hur, Sun Park, Kyongmin Kim, Ho-Joon Shin and Yong-Joon Chwae. https://www.pnas.org/content/115/50/E11721?etoc=

Efferocytosis Fuels Requirements of Fatty Acid Oxidation and the Electron Transport Chain to Polarize Macrophages for Tissue Repair – Shuang Zhang, Samuel Weinberg, Matthew DeBerge, Anastasiia Gainullina, Matthew Schipma, Jason M. Kinchen, Issam Ben-Sahra, David R. Gius, Laurent Yvan- Charvet, Navdeep S. Chandel, Paul T. Schumacker, Edward B. Thorp. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(18)30741-1#%20

Treatment-Induced Tumor Cell Apoptosis and Secondary Necrosis Drive Tumor Progression in the Residual Tumor Microenvironment through MerTK and IDO1 – Thomas A. Werfel, David L. Elion, Bushra Rahman, Donna J. Hicks, Violeta Sanchez, Paula I. Gonzales-Ericsson, Mellissa J. Nixon, Jamaal L. James, Justin M. Balko, Peggy A. Scherle, Holly K. Koblish and Rebecca S. Cook. http://cancerres.aacrjournals.org/content/79/1/171


The SMAC mimetic LCL-161 displays antitumor activity in preclinical models of rituximab-resistant B-cell lymphoma – Kyle Runckel, Matthew J. Barth, Cory Mavis, Juan J. Gu and Francisco J. Hernandez-Ilizaliturri. http://www.bloodadvances.org/content/2/23/3516.abstract?etoc

Dimerization and auto-processing induce caspase-11 protease activation within the non-canonical inflammasome – Connie Ross, Amy H Chan, Jessica Von Pein, Dave Boucher and Kate Schroder. http://life-science-alliance.org/content/1/6/e201800237.abstract

ATP Synthase C-Subunit-Deficient Mitochondria Have a Small Cyclosporine A-Sensitive Channel, but Lack the Permeability Transition Pore – Maria A. Neginskaya, Maria E. Solesio, Elena V. Berezhnaya, Giuseppe F. Amodeo, Nelli Mnatsakanyan, Elizabeth A. Jonas, Evgeny V. Pavlov. https://www.cell.com/cell-reports/fulltext/S2211-1247(18)31963-6


BH3-Mimetic Drugs: Blazing the Trail for New Cancer Medicines – Delphine Merino, Gemma L. Kelly, Guillaume Lessene, Andrew H. Wei, Andrew W. Roberts, Andreas Strasser. https://www.cell.com/cancer-cell/fulltext/S1535-6108(18)30525-7

The Structural Basis of Necroptotic Cell Death Signaling – Emma J. Petrie, Peter E. Czabotar, James M. Murphy. https://www.cell.com/trends/biochemical-sciences/fulltext/S0968-0004(18)30229-9

Role and Regulation of Pro-survival BCL-2 Proteins in Multiple Myeloma – Anne Slomp and Victor Peperzak. https://www.frontiersin.org/articles/10.3389/fonc.2018.00533/full


Special issue on Necroinflammation



* Death and fire: the concept of necroinflammation – Andreas Linkermann

* Necroptosis in anti-viral inflammation – Himani Nailwal and Francis Ka-Ming Chan

* Ferroptosis and necroinflammation, a yet poorly explored link – Bettina Proneth and Marcus Conrad

* Programmed Necrosis and Disease:We interrupt your regular programming to bring you necroinflammation – Eui Ho Kim, Sing-Wai Wong and Jennifer Martinez

* Crashing the computer: apoptosis vs. necroptosis in neuroinflammation – Bradlee L. Heckmann, Bart Tummers and Douglas R. Green

* Necroinflammation emerges as a key regulator of hematopoiesis in health and disease – Philipp J. Jost and Ulrike Höckendorf

* Paving the way for precision medicine v2.0 in intensive care by profiling necroinflammation in biofluids – Tom Vanden Berghe and Eric Hoste

* Pyroptosis versus necroptosis: similarities, differences, and crosstalk – Daniel Frank and James E. Vince

* Comparing the effects of different cell death programs in tumor progression and immunotherapy – Michelle N. Messmer, Annelise G. Snyder and Andrew Oberst


Macrophages regulate the clearance of living cells by calreticulin – Dmitri V. Krysko, Kodi S. Ravichandran and Peter Vandenabeele. https://www.nature.com/articles/s41467-018-06807-9

Glucocorticoid Resistance in Acute Lymphoblastic Leukemia: BIM Finally – Jessie A. Brown, Adolfo Ferrando. https://www.cell.com/cancer-cell/fulltext/S1535-6108(18)30532-4

Venetoclax in AML: aiming for “just right” – Laura C. Michaelis. http://bloodjournal.org/content/133/1/3?etoc

ApoList – November 2018


Efferocytosis / Inflammation

The Mitochondrial Apoptotic Effectors BAX/BAK Activate Caspase-3 and -7 to Trigger NLRP3 Inflammasome and Caspase-8 Driven IL-1β Activation – James E. Vince, Dominic De Nardo, Wenqing Gao, Angelina J. Vince, Cathrine Hall, Kate McArthur, Daniel Simpson, Swarna Vijayaraj, Lisa M. Lindqvist, Philippe Bouillet, Mark A. Rizzacasa, Si Ming Man, John Silke, Seth L. Masters, Guillaume Lessene, David C.S. Huang, Daniel H.D. Gray, Benjamin T. Kile, Feng Shao, Kate E. Lawlor. https://www.cell.com/cell-reports/fulltext/S2211-1247(18)31725-X

BAX/BAK-Induced Apoptosis Results in Caspase-8-Dependent IL-1β Maturation in Macrophages – Dhruv Chauhan, Eva Bartok, Moritz M. Gaidt, Florian J. Bock, Jennifer Herrmann, Jens M. Seeger, Petr Broz, Roland Beckmann, Hamid Kashkar, Stephen W.G. Tait, Rolf Müller, Veit Hornung. https://www.cell.com/cell-reports/fulltext/S2211-1247(18)31691-7

Efferocytosis induces a novel SLC program to promote glucose uptake and lactate release – Sho Morioka, Justin S. A. Perry, Michael H. Raymond, Christopher B. Medina, Yunlu Zhu, Liyang Zhao, Vlad Serbulea, Suna Onengut-Gumuscu, Norbert Leitinger, Sarah Kucenas, Jeffrey C. Rathmell, Liza Makowski and Kodi S. Ravichandran. https://www.nature.com/articles/s41586-018-0735-5

Efferocytosis of apoptotic alveolar epithelial cells is sufficient to initiate lung fibrosis – Kevin K. Kim, Megan R. Dotson, Manisha Agarwal, Jibing Yang, Patrick B. Bradley, Natalia Subbotina, John J. Osterholzer and Thomas H. Sisson. https://www.nature.com/articles/s41419-018-1074-z

Pyroptosis / Gasdermin D / Gasdermin E

Caspase-8 induces cleavage of gasdermin D to elicit pyroptosis during Yersinia infection – Joseph Sarhan, Beiyun C. Liu, Hayley I. Muendlein, Peng Li, Rachael Nilson, Amy Y. Tang, Anthony Rongvaux, Stephen C. Bunnell, Feng Shao, Douglas R. Green, and Alexander Poltorak. http://www.pnas.org/content/115/46/E10888?etoc=

Pathogen blockade of TAK1 triggers caspase-8–dependent cleavage of gasdermin D and cell death – Pontus Orning, Dan Weng, Kristian Starheim, Dmitry Ratner, Zachary Best, Bettina Lee, Alexandria Brooks, Shiyu Xia, Hao Wu, Michelle A. Kelliher, Scott B. Berger, Peter J. Gough, John Bertin, Megan M. Proulx, Jon D. Goguen, Nobuhiko Kayagaki, Katherine A. Fitzgerald, Egil Lien. http://science.sciencemag.org/content/362/6418/1064

ESCRT-dependent membrane repair negatively regulates pyroptosis downstream of GSDMD activation – Sebastian Rühl, Kateryna Shkarina, Benjamin Demarco, Rosalie Heilig, José Carlos Santos, Petr Broz. http://science.sciencemag.org/content/362/6417/956

Shiga Toxin/Lipopolysaccharide Activates Caspase-4 and Gasdermin D to Trigger Mitochondrial Reactive Oxygen Species Upstream of the NLRP3 Inflammasome – Jaye M. Platnich, Hyunjae Chung, Arthur Lau, Christina F. Sandall, Adom Bondzi-Simpson, Huey-Miin Chen, Takanori Komada, Aaron C. Trotman-Grant, Jeremy R. Brandelli, Justin Chun, Paul L. Beck, Dana J. Philpott, Stephen E. Girardin, May Ho, Roger P. Johnson, Justin A. MacDonald, Glen D. Armstrong, Daniel A. Muruve. https://www.cell.com/cell-reports/fulltext/S2211-1247(18)31531-6

Molecular Targeted Therapies Elicit Concurrent Apoptotic and GSDME-Dependent Pyroptotic Tumor Cell Death – Haijiao Lu, Shengzhe Zhang, Jie Wu, Minjiang Chen, Mei-Chun Cai, Yujie Fu, Wenfeng Li, Jing Wang, Xiaojing Zhao, Zhuang Yu, Pengfei Ma and Guanglei Zhuang. http://clincancerres.aacrjournals.org/content/24/23/6066

Gasdermin E Does Not Limit Apoptotic Cell Disassembly by Promoting Early Onset of Secondary Necrosis in Jurkat T Cells and THP-1 Monocytes – Rochelle Tixeira, Bo Shi†, Michael A. F. Parkes, Amy L. Hodge, Sarah Caruso, Mark D. Hulett, Amy A. Baxter, Thanh Kha Phan and Ivan K. H. Poon. https://www.frontiersin.org/articles/10.3389/fimmu.2018.02842/full

Death receptors / FLIP

TBK1 and IKKε prevent TNF-induced cell death by RIPK1 phosphorylation – Elodie Lafont, Peter Draber, Eva Rieser, Matthias Reichert, Sebastian Kupka, Diego de Miguel, Helena Draberova, Anne von Mässenhausen, Amandeep Bhamra, Stephen Henderson, Katarzyna Wojdyla, Avigayil Chalk, Silvia Surinova, Andreas Linkermann and Henning Walczak. https://www.nature.com/articles/s41556-018-0229-6

Fas receptor induces apoptosis of synovial bone and cartilage progenitor populations and promotes bone loss in antigen-induced arthritis – Elvira Lazić Mosler, Nina Lukač, Darja Flegar, Martina Fadljević, Igor Radanović, Hrvoje Cvija, Tomislav Kelava, Sanja Ivčević, Alan Šućur, Antonio Markotić, Vedran Katavić, Ana Marušić, Danka Grčević and Nataša Kovačić. https://www.fasebj.org/doi/abs/10.1096/fj.201801426R?ai=ts&ui=ly8&af=T

Cell polarity and adherens junction formation inhibit epithelial Fas cell death receptor signaling – Laurent Gagnoux-Palacios, Hala Awina, Stéphane Audebert, Aurélie Rossin, Magali Mondin, Franck Borgese, Carlota Planas-Botey, Amel Mettouchi, Jean-Paul Borg and Anne-Odile Hueber. http://jcb.rupress.org/content/217/11/3839?etoc

Cytoplasmic FLIP(S) and nuclear FLIP(L) mediate resistance of castrate-resistant prostate cancer to apoptosis induced by IAP antagonists – Christopher McCann, Nyree Crawford, Joanna Majkut, Caitriona Holohan, Chris W. D. Armstrong, Pamela J. Maxwell, Chee Wee Ong, Melissa J. LaBonte, Simon S. McDade, David J. Waugh and Daniel B. Longley. https://www.nature.com/articles/s41419-018-1125-5


A Novel MCL1 Inhibitor Combined with Venetoclax Rescues Venetoclax-Resistant Acute Myelogenous Leukemia – Haley E. Ramsey, Melissa A. Fischer, Taekyu Lee, Agnieszka E. Gorska, Maria Pia Arrate, Londa Fuller, Kelli L. Boyd, Stephen A. Strickland, John Sensintaffar, Leah J. Hogdal, Gregory D. Ayers, Edward T. Olejniczak, Stephen W. Fesik and Michael R. Savona. http://cancerdiscovery.aacrjournals.org/content/8/12/1566

AMG 176, a Selective MCL1 Inhibitor, Is Effective in Hematologic Cancer Models Alone and in Combination with Established Therapies – Sean Caenepeel, Sean P. Brown, Brian Belmontes, Gordon Moody, Kathleen S. Keegan, Danny Chui, Douglas A. Whittington, Xin Huang, Leszek Poppe, Alan C. Cheng, Mario Cardozo, Jonathan Houze, Yunxiao Li, Brian Lucas, Nick A. Paras, Xianghong Wang, Joshua P. Taygerly, Marc Vimolratana, Manuel Zancanella, Liusheng Zhu, Elaina Cajulis, Tao Osgood, Jan Sun, Leah Damon, Regina K. Egan, Patricia Greninger, Joseph D. McClanaghan, Jianan Gong, Donia Moujalled, Giovanna Pomilio, Pedro Beltran, Cyril H. Benes, Andrew W. Roberts, David C. Huang, Andrew Wei, Jude Canon, Angela Coxon and Paul E. Hughes. http://cancerdiscovery.aacrjournals.org/content/8/12/1582

Exploiting MCL1 Dependency with Combination MEK + MCL1 Inhibitors Leads to Induction of Apoptosis and Tumor Regression in KRAS-Mutant Non–Small Cell Lung Cancer – Varuna Nangia, Faria M. Siddiqui, Sean Caenepeel, Daria Timonina, Samantha J. Bilton, Nicole Phan, Maria Gomez-Caraballo, Hannah L. Archibald, Chendi Li, Cameron Fraser, Diamanda Rigas, Kristof Vajda, Lorin A. Ferris, Michael Lanuti, Cameron D. Wright, Kevin A. Raskin, Daniel P. Cahill, John H. Shin, Colleen Keyes, Lecia V. Sequist, Zofia Piotrowska, Anna F. Farago, Christopher G. Azzoli, Justin F. Gainor, Kristopher A. Sarosiek, Sean P. Brown, Angela Coxon, Cyril H. Benes, Paul E. Hughes and Aaron N. Hata. http://cancerdiscovery.aacrjournals.org/content/8/12/1598

Increased Synthesis of MCL-1 Protein Underlies Initial Survival of EGFR-Mutant Lung Cancer to EGFR Inhibitors and Provides a Novel Drug Target – Kyung-A Song, Yasuyuki Hosono, Crystal Turner, Sheeba Jacob, Timothy L. Lochmann, Yoshiko Murakami, Neha U. Patel, Jungoh Ham, Bin Hu, Krista M. Powell, Colin M. Coon, Brad E. Windle, Yuko Oya, Jennifer E. Koblinski, Hisashi Harada, Joel D. Leverson, Andrew J. Souers, Aaron N. Hata, Sosipatros Boikos, Yasushi Yatabe, Hiromichi Ebi and Anthony C. Faber. http://clincancerres.aacrjournals.org/content/24/22/5658

Survival of midbrain dopamine neurons depends on the Bcl2 factor Mcl1 – Edward J. Robinson, Sebastian P. Aguiar, Willemieke M. Kouwenhoven, Dorinde S. Starmans, Lars von Oerthel et al. https://www.nature.com/articles/s41420-018-0125-7

Other Bcl-2 family proteins

VDAC2 enables BAX to mediate apoptosis and limit tumor development – Hui San Chin, Mark X. Li, Iris K. L. Tan, Robert L. Ninnis, Boris Reljic, Kristen Scicluna, Laura F. Dagley, Jarrod J. Sandow, Gemma L. Kelly, Andre L. Samson, Stephane Chappaz, Seong L. Khaw, Catherine Chang, Andrew Morokoff, Kerstin Brinkmann, Andrew Webb, Colin Hockings, Cathrine M. Hall, Andrew J. Kueh, Michael T. Ryan, Ruth M. Kluck, Philippe Bouillet, Marco J. Herold, Daniel H. D. Gray, David C. S. Huang, Mark F. van Delft and Grant Dewson. https://www.nature.com/articles/s41467-018-07309-4

Mannose impairs tumour growth and enhances chemotherapy – Pablo Sierra Gonzalez, James O’Prey, Simone Cardaci, Valentin J. A. Barthet, Jun-ichi Sakamaki, Florian Beaumatin, Antonia Roseweir, David M. Gay, Gillian Mackay, Gaurav Malviya, Elżbieta Kania, Shona Ritchie, Alice D. Baudot, Barbara Zunino, Agata Mrowinska, Colin Nixon, Darren Ennis, Aoisha Hoyle, David Millan, Iain A. McNeish, Owen J. Sansom, Joanne Edwards and Kevin M. Ryan. https://www.nature.com/articles/s41586-018-0729-3

Venetoclax with azacitidine disrupts energy metabolism and targets leukemia stem cells in patients with acute myeloid leukemia – Daniel A. Pollyea, Brett M. Stevens[…], Craig T. Jordan. https://www.nature.com/articles/s41591-018-0233-1

And the companion paper:
Inhibition of Amino Acid Metabolism Selectively Targets Human Leukemia Stem Cells – Courtney L. Jones, Brett M. Stevens, Angelo D’Alessandro, Julie A. Reisz, Rachel Culp-Hill, Travis Nemkov, Shanshan Pei, Nabilah Khan, Biniam Adane, Haobin Ye, Anna Krug, Dominik Reinhold, Clayton Smith, James DeGregori, Daniel A. Pollyea, Craig T. Jordan. https://www.cell.com/cancer-cell/fulltext/S1535-6108(18)30471-9

Tamoxifen overrides autophagy inhibition in Beclin-1-deficient glioma cells and their resistance to adenovirus-mediated oncolysis via upregulation of PUMA and BAX – Natalya V. Kaverina, Zaira G. Kadagidze, Anton V. Borovjagin, Apollon I. Karseladze, Chung Kwon Kim, Maciej S. Lesniak, Jason Miska, Peng Zhang, Maria A. Baryshnikova, Ting Xiao, David Ornelles, Charles Cobbs, Andrey Khramtsov and Ilya V. Ulasov. https://www.nature.com/articles/s41388-018-0395-9

NOXA genetic amplification or pharmacologic induction primes lymphoma cells to BCL2 inhibitor-induced cell death – Yuxuan Liu, Patrizia Mondello, Tatiana Erazo, Neeta Bala Tannan, Zahra Asgari, Elisa de Stanchina, Gouri Nanjangud, Venkatraman E. Seshan, Shenqiu Wang, Hans-Guido Wendel and Anas Younes. http://www.pnas.org/content/115/47/12034?etoc=

Cytoplasmic pro-apoptotic function of the tumor suppressor p73 is mediated through a modified mode of recognition of the anti-apoptotic regulator Bcl-XL – Mi-Kyung Yoon, Bu-Yeon Kim, Ji-Young Lee, Ji-Hyang Ha, Sung Ah Kim, Dong-Hwa Lee, Min-Sung Lee, Mi-Kyung Lee, Jin Sun Choi, Jin Hwa Cho, Jeong-Hoon Kim, Sunhong Kim, Jaewhan Song, Sung Goo Park, Byoung Chul Park, Kwang-Hee Bae, Sang Un Choi and Seung-Wook Chi. http://www.jbc.org/content/early/2018/11/14/jbc.RA118.003061.abstract


Caspases maintain tissue integrity by an apoptosis-independent inhibition of cell migration and invasion – Anna Gorelick-Ashkenazi, Ron Weiss, Lena Sapozhnikov, Anat Florentin, Lama Tarayrah-Ibraheim, Dima Dweik, Keren Yacobi-Sharon and Eli Arama. https://www.nature.com/articles/s41467-018-05204-6

Identification of a novel caspase cleavage site in huntingtin that regulates mutant huntingtin clearance – Dale D. O. Martin, Mandi E. Schmidt, Yen T. Nguyen, Nikola Lazic and Michael R. Hayden. https://www.fasebj.org/doi/abs/10.1096/fj.201701510RRR?ai=ts&ui=ly8&af=T

14‐3‐3 protein masks the nuclear localization sequence of caspase‐2 – Aneta Smidova, Miroslava Alblova, Dana Kalabova, Katarina Psenakova, Michal Rosulek, Petr Herman, Tomas Obsil, Veronika Obsilova. https://febs.onlinelibrary.wiley.com/doi/10.1111/febs.14670

Tri-arginine exosite patch of caspase-6 recruits substrates for hydrolysis – Derek J MacPherson, Caityln L Mills, Mary Jo Ondrechen and Jeanne A. Hardy. http://www.jbc.org/content/early/2018/11/12/jbc.RA118.005914.abstract

p53 accumulation following cytokinesis failure in the absence of caspase-2 (letter) – Yoon Lim, Dylan De Bellis, Loretta Dorstyn and Sharad Kumar. https://www.nature.com/articles/s41418-018-0161-0

microRNA-378 promotes autophagy and inhibits apoptosis in skeletal muscle – Yan Li, Jingjing Jiang, Wei Liu, Hui Wang, Lei Zhao, Shengnan Liu, Peng Li, Shengjie Zhang, Chao Sun, Yuting Wu, Shuxian Yu, Xihua Li, Hui Zhang, Haifeng Qian, Duo Zhang, Feifan Guo, Qiwei Zhai, Qiurong Ding, Li Wang and Hao Ying. http://www.pnas.org/content/115/46/E10849?etoc=

Platelet CD36 signaling through ERK5 promotes caspase-dependent procoagulant activity and fibrin deposition in vivo – Moua Yang, Andaleb Kholmukhamedov, Marie L. Schulte, Brian C. Cooley, Na’il O. Scoggins, Jeremy P. Wood, Scott J. Cameron, Craig N. Morrell, Shawn M. Jobeand Roy L. Silverstein. http://www.bloodadvances.org/content/2/21/2848.abstract?etoc


Axonal degeneration induced by glutamate excitotoxicity is mediated by necroptosis – Diego E. Hernández, Natalia A. Salvadores, Guillermo Moya-Alvarado, Romina J. Catalán, Francisca C. Bronfman and Felipe A. Court. http://jcs.biologists.org/content/131/22/jcs214684?etoc

Soluble TNF-like weak inducer of apoptosis (TWEAK) enhances poly(I:C)-induced RIPK1-mediated necroptosis – Mohamed A. Anany, Jennifer Kreckel, Simone Füllsack, Alevtina Rosenthal, Christoph Otto, Daniela Siegmund and Harald Wajant. https://www.nature.com/articles/s41419-018-1137-1

hsa-miR-500a-3P alleviates kidney injury by targeting MLKL-mediated necroptosis in renal epithelial cells – Ling Jiang, Xue-Qi Liu, Qiuying Ma, Qin Yang, Li Gao, Hai-Di Li, Jia-Nan Wang, Biao Wei, Jiagen Wen, Jun Li, Yong-Gui Wu and Xiao-Ming Meng. https://www.fasebj.org/doi/abs/10.1096/fj.201801711R?ai=ts&ui=ly8&af=T


The Proton-Coupled Monocarboxylate Transporter Hermes Is Necessary for Autophagy during Cell Death – Panagiotis D. Velentzas, Lejie Zhang, Gautam Das, Tsun-Kai Chang, Charles Nelson, William R. Kobertz, Eric H. Baehrecke. https://www.cell.com/developmental-cell/fulltext/S1534-5807(18)30744-5

Intracellular transport is accelerated in early apoptotic cells – Bo Li, Shuo-Xing Dou, Jing-Wen Yuan, Yu-Ru Liu, Wei Li, Fangfu Ye, Peng-Ye Wang and Hui Li. http://www.pnas.org.sire.ub.edu/content/115/48/12118?etoc=

The yeast mitochondrial permeability transition is regulated by reactive oxygen species, endogenous Ca2+ and Cpr3, mediating cell death – Yoshiko Kamei, Masami Koushi, Yasunori Aoyama, Rei Asakai. https://www.sciencedirect.com/science/article/pii/S000527281830197X

microRNAs selectively protect hub cells of the germline stem cell niche from apoptosis – Marina Volin, Maayan Zohar-Fux, Oren Gonen, Lilach Porat-Kuperstein and Hila Toledano. http://jcb.rupress.org/content/217/11/3829?etoc


FLIP as a therapeutic target in cancer – Luke Humphreys, Margarita Espona‐Fiedler, Daniel B. Longley. https://febs.onlinelibrary.wiley.com/doi/10.1111/febs.14523

Counting on Death – Quantitative aspects of Bcl‐2 family regulation – Annika Hantusch, Markus Rehm, Thomas Brunner. https://febs.onlinelibrary.wiley.com/doi/10.1111/febs.14516

Cell-in-cell phenomena in cancer – Stefano Fais and Michael Overholtzer. https://www.nature.com/articles/s41568-018-0073-9

FADD at the Crossroads between Cancer and Inflammation – Sara Mouasni, Léa Tourneur. https://www.cell.com/trends/immunology/fulltext/S1471-4906(18)30189-3

Hematologic Tumor Cell Resistance to the BCL-2 Inhibitor Venetoclax: A Product of Its Microenvironment? – Joel D. Leverson and Dan Cojocari. https://www.frontiersin.org/articles/10.3389/fonc.2018.00458/full

Dependence receptors – the dark side awakens – Ana‐Maria Negulescu, Patrick Mehlen. https://febs.onlinelibrary.wiley.com/doi/10.1111/febs.14507


Unleashing Blocked Apoptosis in Cancer Cells: New MCL1 Inhibitors Find Their Groove – Brian Leber, Justin Kale and David W. Andrews. http://cancerdiscovery.aacrjournals.org/content/8/12/1511?

TBK1 and IKKε restrain cell death – Klaus Heger and Vishva M. Dixit. https://www.nature.com/articles/s41556-018-0239-4

Timed degradation of Mcl-1 controls mitotic cell death – Paul R. Clarke, Lindsey A. Allan and Agnieszka Skowyra. https://www.tandfonline.com/doi/full/10.1080/23723556.2018.1516450

Necroptosis is key to axonal degeneration after excitotoxicity. http://jcs.biologists.org/content/131/22/e2202?etoc

ApoList – October 2018

Bcl-2 family proteins

Humanized Mcl-1 mice enable accurate preclinical evaluation of MCL-1 inhibitors destined for clinical use – Margs S. Brennan, Catherine Chang, Lin Tai, Guillaume Lessene, Andreas  Strasser, Grant Dewson, Gemma L. Kelly and Marco J. Herold. http://bloodjournal.org/content/132/15/1573.abstract?etoc

Discovery of a small-molecule inhibitor of specific serine residue BAD phosphorylation – Vijay Pandey, Baocheng Wang, Chakrabhavi Dhananjaya Mohan, Ainiah Rushdiana Raquib, Shobith Rangappa, Venkatachalaiah Srinivasa, Julian E. Fuchs, Kesturu S. Girish, Tao Zhu, Andreas Bender, Lan Ma, Zhinan Yin, Basappa, Kanchugarakoppal S. Rangappa and Peter E. Lobie. http://www.pnas.org/content/115/44/E10505?etoc=

Activation of the apoptotic pathway during prolonged prometaphase blocks daughter cell proliferation – Yumi Uetake and Greenfield Sluder. https://www.molbiolcell.org/doi/10.1091/mbc.E18-01-0026?ai=s5&ui=2oy6&af=T

Ursolic acid facilitates apoptosis in rheumatoid arthritis synovial fibroblasts by inducing SP1-mediated Noxa expression and proteasomal degradation of Mcl-1 – Eugene Y. Kim, Kuladeep Sudini, Anil K. Singh, Mahamudul Haque, Douglas Leaman, Sadik Khuder and Salahuddin Ahmed. https://www.fasebj.org/doi/abs/10.1096/fj.201800425R?ai=s4&ui=ly8&af=T

Tyrosine Kinase Inhibitors Increase MCL1 Degradation and in Combination with BCLXL/BCL2 Inhibitors Drive Prostate Cancer Apoptosis – Seiji Arai, Oliver Jonas, Matthew A. Whitman, Eva Corey, Steven P. Balk and Sen Chen. http://clincancerres.aacrjournals.org/content/24/21/5458

Death receptors

CD95/Fas ligand mRNA is toxic to cells – Will Putzbach, Ashley Haluck-Kangas … Marcus E Peter. https://elifesciences.org/articles/38621

Linear ubiquitination of cFLIP induced by LUBAC contributes to TNFa-induced apoptosis – Yong Tang, Donghyun Joo, Guangna Liu, Hailin Tu, Jeffrey You, Jianping Jin, Xueqiang Zhao, Mien-Chie Hung and Xin Lin. http://www.jbc.org/content/early/2018/10/25/jbc.RA118.005449.abstract


Picomolar zinc binding modulates formation of Bcl10-nucleating assemblies of the caspase recruitment domain (CARD) of CARD9 – Michael J. Holliday, Ryan Ferrao, Gladys de Leon Boenig, Alberto Estevez, Elizabeth Helgason, Alexis Rohou, Erin C. Dueber and Wayne J. Fairbrother. http://www.jbc.org/content/293/43/16803.abstract.html

Cryo-EM structures of ASC and NLRC4 CARD filaments reveal a unified mechanism of nucleation and activation of caspase-1 – Yang Li, Tian-Min Fu, Alvin Lu, Kristen Witt, Jianbin Ruan, Chen Shen and Hao Wu. http://www.pnas.org/content/115/43/10845?etoc=


LC3-Associated Phagocytosis in Myeloid Cells Promotes Tumor Immune Tolerance – Larissa D. Cunha, Mao Yang, Robert Carter, Clifford Guy, Lacie Harris, Jeremy C. Crawford, Giovanni Quarato, Emilio Boada-Romero, Halime Kalkavan, Michael D.L. Johnson, Sivaraman Natarajan, Meghan E. Turnis, David Finkelstein, Joseph T. Opferman, Charles Gawad, Douglas R. Green. https://www.cell.com/cell/fulltext/S0092-8674(18)31122-X

Regulatory T Cells Promote Macrophage Efferocytosis during Inflammation Resolution – Jonathan D. Proto, Amanda C. Doran, Galina Gusarova, Arif Yurdagul Jr., Erdi Sozen, Manikandan Subramanian, Mohammad N. Islam, Christina C. Rymond, Jasper Du, Jaime Hook, George Kuriakose, Jahar Bhattacharya, Ira Tabas. https://www.cell.com/immunity/fulltext/S1074-7613(18)30335-2

RAB-35 and ARF-6 GTPases Mediate Engulfment and Clearance Following Linker Cell-Type Death – Lena M. Kutscher, Wolfgang Keil, Shai Shaham. https://www.cell.com/developmental-cell/fulltext/S1534-5807(18)30685-3

Apoptotic β-cells induce macrophage reprogramming under diabetic conditions – Meliza G. Ward, Ge Li and Mingming Hao. http://www.jbc.org/content/293/42/16160.abstract.html


The glutathione redox system is essential to prevent ferroptosis caused by impaired lipid metabolism in clear cell renal cell carcinoma – Heike Miess, Beatrice Dankworth, Arvin M. Gouw, Mathias Rosenfeldt, Werner Schmitz, Ming Jiang, Becky Saunders, Michael Howell, Julian Downward, Dean W. Felsher, Barrie Peck and Almut Schulze. https://www.nature.com/articles/s41388-018-0315-z

Activation of ferritinophagy is required for the RNA-binding protein ELAVL1/HuR to regulate ferroptosis in hepatic stellate cells – Zili Zhang, Zhen Yao, Ling Wang, Hai Ding, Jiangjuan Shao, Anping Chen, Feng Zhang and Shizhong Zheng. https://www.tandfonline.com/doi/full/10.1080/15548627.2018.1503146


Mixed Lineage Kinase Domain-like Protein MLKL Breaks Down Myelin following Nerve Injury – Zhengxin Ying, Chenjie Pan, Tianyu Shao, Liqing Liu, Lin Li, Dejia Guo, Sitao Zhang, Tianyi Yuan, Ran Cao, Zhaodi Jiang, She Chen, Fengchao Wang, Xiaodong Wang. https://www.cell.com/molecular-cell/fulltext/S1097-2765(18)30782-2

Global Profiling of Proteolysis from the Mitochondrial Amino Terminome during Early Intrinsic Apoptosis Prior to Caspase-3 Activation – Natalie C. Marshall, Theo Klein, Maichael Thejoe, Niklas von Krosigk, Jayachandran Kizhakkedathu, B. Brett Finlay and Christopher M. Overall. https://pubs.acs.org/doi/10.1021/acs.jproteome.8b00675#.W9q0UN6qJiJ

Siglec-7 engagement by GBS β-protein suppresses pyroptotic cell death of natural killer cells – Jerry J. Fong, Chih-Ming Tsai, Sudeshna Saha, Victor Nizet, Ajit Varki and Jack D. Bui. http://www.pnas.org/content/115/41/10410?etoc=

Subcellular Hsp70 Inhibitors Promote Cancer Cell Death via Different Mechanisms – Sang-Hyun Park, Kyung-Hwa Baek, Insu Shin, Injae Shin. https://www.sciencedirect.com/science/article/pii/S2451945618302241


Topology of active, membrane-embedded Bax in the context of a toroidal pore – Stephanie Bleicken, Tufa E. Assafa, Carolin Stegmueller, Alice Wittig, Ana J. Garcia-Saez and Enrica Bordignon. https://www.nature.com/articles/s41418-018-0184-6

Neurophagy, the phagocytosis of live neurons and synapses by glia, contributes to brain development and disease – Anna Vilalta, Guy C. Brown. https://febs.onlinelibrary.wiley.com/doi/10.1111/febs.14323

No Parkin Zone: Mitophagy without Parkin – Elodie Villa, Sandrine Marchetti, Jean-Ehrland Ricci. https://www.cell.com/trends/cell-biology/fulltext/S0962-8924(18)30125-9


MIM through MOM: the awakening of Bax and Bak pores – Katia Cosentino, Ana J García‐Sáez. http://emboj.embopress.org/content/37/17/e100340

MLKL Reveals Its Friendly Face: A Role in Nerve Regeneration – Peter Vandenabeele, Wim Declercq, Ria Roelandt, Tom Vanden Berghe. https://www.cell.com/molecular-cell/fulltext/S1097-2765(18)30885-2

Neighbourhood deaths cause a switch in cancer subtype – Eli Pikarsky. https://www.nature.com/articles/d41586-018-06217-3

Neighbourly deaths dictate fatehttps://www.nature.com/articles/s41568-018-0064-x

Annual Meeting of the International Society of Cancer Metabolism (ISCaM): Cancer Metabolism – Sofia Avnet, Nicola Baldini, Lucie Brisson, Angelo De Milito, Angela M. Otto, Silvia Pastoreková, Paolo E. Porporato, Gyorgy Szabadkai and Pierre Sonveaux. https://www.frontiersin.org/articles/10.3389/fonc.2018.00329/full

ApoList – September 2018


Caspases and cFLIP

ER Stress Drives Lipogenesis and Steatohepatitis via Caspase-2 Activation of S1P – Ju Youn Kim, Ricard Garcia-Carbonell, Shinichiro Yamachika, Peng Zhao, Debanjan Dhar, Rohit Loomba, Randal J. Kaufman, Alan R. Saltiel, Michael Karin. https://www.cell.com/cell/fulltext/S0092-8674(18)31036-5

Caspase-1 inhibition alleviates cognitive impairment and neuropathology in an Alzheimer’s disease mouse model – Joseph Flores, Anastasia Noël, Bénédicte Foveau, Jeffrey Lynham, Clotilde Lecrux & Andréa C. LeBlanc. https://www.nature.com/articles/s41467-018-06449-x

Inhibitor of apoptosis proteins (IAPs) mediate collagen type XI alpha 1-driven cisplatin resistance in ovarian cancer – Miran Rada, Sameera Nallanthighal, Jennifer Cha, Kerry Ryan, Jessica Sage, Catherine Eldred, Maria Ullo, Sandra Orsulic & Dong-Joo Cheon. https://www.nature.com/articles/s41388-018-0297-x

Hypercapnia increases airway smooth muscle contractility via caspase-7-mediated miR-133a-RhoA signaling – Masahiko Shigemura , Emilia Lecuona, Martín Angulo, Tetsuya Homma, Diego A. Rodríguez, Francisco J. Gonzalez-Gonzalez, Lynn C. Welch, Luciano Amarelle, Seok-Jo Kim, Naftali Kaminski, G. R. Scott Budinger, Julian Solway, Jacob I. Sznajder. http://stm.sciencemag.org/content/10/457/eaat1662

PIDD-dependent activation of caspase-2-mediated mitochondrial injury in E1A-induced cellular sensitivity to macrophage nitric oxide-induced apoptosis – Jay R. Radke, Iris Figueroa, John M. Routes & James L. Cook. https://www.nature.com/articles/s41420-018-0100-3

Release of c-FLIP brake selectively sensitizes human cancer cells to TLR3-mediated apoptosis – Lugain Alkurdi, François Virard, Béatrice Vanbervliet, Kathrin Weber, Florent Toscano, Marc Bonnin, Nolwenn Le Stang, Sylvie Lantuejoul, Olivier Micheau, Toufic Renno, Serge Lebecque & Yann Estornes. https://www.nature.com/articles/s41419-018-0850-0

Bcl-2 family proteins

Phosphorylation switches Bax from promoting to inhibiting apoptosis thereby increasing drug resistance – Justin Kale, Ozgur Kutuk, Glauber Costa Brito, Tallulah S Andrews, Brian Leber, Anthony Letai and David W Andrews. http://EMBOr.embopress.org/content/19/9/e45235?etoc

Topology of active, membrane-embedded Bax in the context of a toroidal pore – Stephanie Bleicken, Tufa E. Assafa, Carolin Stegmueller, Alice Wittig, Ana J. Garcia-Saez & Enrica Bordignon. https://www.nature.com/articles/s41418-018-0184-6

Atypical APC/C‐dependent degradation of Mcl‐1 provides an apoptotic timer during mitotic arrest – Lindsey A Allan, Agnieszka Skowyra, Katie I Rogers, Désirée Zeller and Paul R Clarke. http://EMBOJ.embopress.org/content/37/17/e96831?etoc

Comprehensive Safety Analysis of Venetoclax Monotherapy for Patients with Relapsed/Refractory Chronic Lymphocytic Leukemia – Matthew S. Davids, Michael Hallek, William Wierda, Andrew W. Roberts, Stephan Stilgenbauer, Jeffrey A. Jones, John F. Gerecitano, Su Young Kim, Jalaja Potluri, Todd Busman, Andrea Best, Maria E. Verdugo, Elisa Cerri, Monali Desai, Peter Hillmen and John F. Seymour. http://clincancerres.aacrjournals.org/content/24/18/4371

SNAP23 regulates BAX-dependent adipocyte programmed cell death independently of canonical macroautophagy – Daorong Feng, Dulguun Amgalan, Rajat Singh, Jianwen Wei, Jennifer Wen, Tszki Peter Wei, Timothy E. McGraw, Richard N. Kitsis, and Jeffrey E. Pessin. https://www.jci.org/articles/view/99217

BCL-2 selective inhibitor ABT-199 primes rhabdomyosarcoma cells to histone deacetylase inhibitor-induced apoptosis – Ulrike Heinicke, Tinka Haydn, Sarah Kehr, Meike Vogler & Simone Fulda. https://www.nature.com/articles/s41388-018-0212-5

Bcl-xl as the most promising Bcl-2 family member in targeted treatment of chondrosarcoma – Yvonne de Jong, David Monderer, Emeline Brandinelli, Morgane Monchanin, Brendy E. van den Akker, Jolieke G. van Oosterwijk, Jean Yves Blay, Aurélie Dutour & Judith V. M. G. Bovée. https://www.nature.com/articles/s41389-018-0084-0

Mex-3B induces apoptosis by inhibiting miR-92a access to the Bim-3’UTR – Takeaki Oda, Yusuke Yamazumi, Takatoshi Hiroko, Atsushi Kamiya, Saori Kiriya, Saki Suyama, Yumi Shiozaki-Sato & Tetsu Akiyama. https://www.nature.com/articles/s41388-018-0336-7

MEK inhibitors induce apoptosis via FoxO3a-dependent PUMA induction in colorectal cancer cells – Lin Lin, Dapeng Ding, Yanmei Jiang, Yan Li & Shijun Li. https://www.nature.com/articles/s41389-018-0078-y

Subtle Changes in the Levels of BCL-2 Proteins Cause Severe Craniofacial Abnormalities – Stephanie Grabow, Andrew J. Kueh, Francine Ke, Hannah K. Vanyai, Bilal N. Sheikh, Michael A. Dengler, William Chiang, Samantha Eccles, Ian M. Smyth, Lynelle K. Jones, Frederic J. de Sauvage, Mark Scott, Lachlan Whitehead, Anne K. Voss, Andreas Strasser. https://www.cell.com/cell-reports/fulltext/S2211-1247(18)31334-2

Misoprostol regulates Bnip3 repression and alternative splicing to control cellular calcium homeostasis during hypoxic stress – Jared T. Field, Matthew D. Martens, Wajihah Mughal, Yan Hai, Donald Chapman, Grant M. Hatch, Tammy L. Ivanco, William Diehl-Jones & Joseph W. Gordon. https://www.nature.com/articles/s41420-018-0104-z

BH3 mimetics induce apoptosis independent of DRP-1 in melanoma – Nabanita Mukherjee, Andrew Strosnider, Bay Vagher, Karoline A. Lambert, Sarah Slaven, William A. Robinson, Carol M. Amato, Kasey L. Couts, Judson G. T. Bemis, Jacqueline A. Turner, David A. Norris& Yiqun G. Shellman. https://www.nature.com/articles/s41419-018-0932-z

Sensitizing non-small cell lung cancer to BCL-xL-targeted apoptosis – Qi Shen, Jun Li, Junhua Mai, Zhe Zhang, Andrew Fisher, Xiaoyan Wu, Zhaoqi Li, Maricela R. Ramirez, Shuqing Chen & Haifa Shen. https://www.nature.com/articles/s41419-018-1040-9

Death receptors

LUBAC prevents lethal dermatitis by inhibiting cell death induced by TNF, TRAIL and CD95L – Lucia Taraborrelli, Nieves Peltzer, Antonella Montinaro, Sebastian Kupka, Eva Rieser, Torsten Hartwig, Aida Sarr, Maurice Darding, Peter Draber, Tobias L. Haas, Ayse Akarca, Teresa Marafioti, Manolis Pasparakis, John Bertin, Peter J. Gough, Philippe Bouillet, Andreas Strasser, Martin Leverkus, John Silke & Henning Walczak. https://www.nature.com/articles/s41467-018-06155-8

Delivery of a TNF-α–derived peptide by nanoparticles enhances its antitumor activity by inducing cell-cycle arrest and caspase-dependent apoptosis – Qiuxia Yan, Xueming Chen, Huizhen Gong, Pei Qiu, Xing Xiao, Shiying Dang, An Hong, and Yi Ma. https://www.fasebj.org/doi/abs/10.1096/fj.201800377R?ai=ts&ui=ly8&af=T

Platelet-RBC interaction mediated by FasL/FasR induces procoagulant activity important for thrombosis – Christoph Klatt, Irena Krüger, Saskia Zey, Kim-Jürgen Krott, Martina Spelleken, Nina Sarah Gowert, Alexander Oberhuber, Lena Pfaff, Wiebke Lückstädt, Kerstin Jurk, Martin Schaller, Hadi Al-Hasani, Jürgen Schrader, Steffen Massberg, Konstantin Stark, Hubert Schelzig, Malte Kelm, and Margitta Elvers. https://www.jci.org/articles/view/92077

Elevated A20 promotes TNF-induced and RIPK1-dependent intestinal epithelial cell death – Ricard Garcia-Carbonell, Jerry Wong, Ju Youn Kim, Lisa Abernathy Close, Brigid S. Boland, Thomas L. Wong, Philip A. Harris, Samuel B. Ho, Soumita Das, Peter B. Ernst, Roman Sasik, William J. Sandborn, John Bertin, Pete J. Gough, John T. Chang, Michelle Kelliher, David Boone, Monica Guma, and Michael Karin. http://www.pnas.org/content/115/39/E9192?etoc=

K6 linked polyubiquitylation of FADD by CHIP prevents death inducing signaling complex formation suppressing cell death – Jinho Seo, Eun-Woo Lee, Jihye Shin, Daehyeon Seong, Young Woo Nam, Manhyung Jeong, Seon-Hyeong Lee, Cheolju Lee & Jaewhan Song. https://www.nature.com/articles/s41388-018-0323-z

TNFR2 unlocks a RIPK1 kinase activity-dependent mode of proinflammatory TNFR1 signaling – Daniela Siegmund, Martin Ehrenschwender & Harald Wajant. https://www.nature.com/articles/s41419-018-0973-3

Ceramide synthase-6 confers resistance to chemotherapy by binding to CD95/Fas in T-cell acute lymphoblastic leukemia – Dattesh Verlekar, Sung-Jen Wei, Hwangeui Cho, Shengping Yang & Min H. Kang. https://www.nature.com/articles/s41419-018-0964-4

TNFα sensitizes hepatocytes to FasL-induced apoptosis by NFκB-mediated Fas upregulation – Laura Faletti, Lukas Peintner, Simon Neumann, Sandra Sandler, Thomas Grabinger, Sabine Mac Nelly, Irmgard Merfort, Chun-Hao Huang, Darjus Tschaharganeh, Tae-Won Kang, Florian Heinzmann, Luana D’Artista, Ulrich Maurer, Thomas Brunner, Scott Lowe, Lars Zender & Christoph Borner. https://www.nature.com/articles/s41419-018-0935-9

Necroptosis, RIP kinases, MLKL

Necroptosis microenvironment directs lineage commitment in liver cancer – Marco Seehawer, Florian Heinzmann, Luana D’Artista, Jule Harbig, Pierre-François Roux, Lisa Hoenicke, Hien Dang, Sabrina Klotz, Lucas Robinson, Grégory Doré, Nir Rozenblum, Tae-Won Kang, Rishabh Chawla, Thorsten Buch, Mihael Vucur, Mareike Roth, Johannes Zuber, Tom Luedde, Bence Sipos, Thomas Longerich, Mathias Heikenwälder, Xin Wei Wang, Oliver Bischof & Lars Zender. https://www.nature.com/articles/s41586-018-0519-y

TBK1 Suppresses RIPK1-Driven Apoptosis and Inflammation during Development and in Aging – Daichao Xu, Taijie Jin, Hong Zhu, Hongbo Chen, Dimitry Ofengeim, Chengyu Zou, Lauren Mifflin, Lifeng Pan, Palak Amin, Wanjin Li, Bing Shan, Masanori Gomi Naito, Huyan Meng, Ying Li, Heling Pan, Liviu Aron, Xian Adiconis, Joshua Z. Levin, Bruce A. Yankner, Junying Yuan. https://www.cell.com/cell/fulltext/S0092-8674(18)30969-3

Necroptosis mediates myofibre death in dystrophin-deficient mice – Jennifer E. Morgan, Alexandre Prola, Virginie Mariot, Veronica Pini, Jinhong Meng, Christophe Hourde, Julie Dumonceaux, Francesco Conti, Frederic Relaix, Francois-Jerôme Authier, Laurent Tiret, Francesco Muntoni & Maximilien Bencze. https://www.nature.com/articles/s41467-018-06057-9

RIPK3-MLKL-mediated necroinflammation contributes to AKI progression to CKD – Hui Chen, Yulu Fang, Jianfeng Wu, Hong Chen, Zhenhuan Zou, Xiaohong Zhang, Jing Shao & Yanfang Xu. https://www.nature.com/articles/s41419-018-0936-8

RIPK1 is a critical modulator of both tonic and TLR-responsive inflammatory and cell death pathways in human macrophage differentiation – Julian Buchrieser, Maria Jose Oliva-Martin, Michael D. Moore, Joshua C. D. Long, Sally A. Cowley, Jose Antonio Perez-Simón, William James & Jose Luis Venero. https://www.nature.com/articles/s41419-018-1053-4

BRAF and AXL oncogenes drive RIPK3 expression loss in cancer – Ayaz Najafov , Ioannis K. Zervantonakis, Adnan K. Mookhtiar, Patricia Greninger, Ryan J. March, Regina K. Egan, Hoang Son Luu, Daniel G. Stover, Ursula A. Matulonis, Cyril H. Benes, Junying Yuan. https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.2005756

The pseudokinase MLKL activates PAD4-dependent NET formation in necroptotic neutrophils – Akshay A. D’Cruz , Mary Speir, Meghan Bliss-Moreau, Sylvia Dietrich, Shu Wang, Alyce A. Chen, Mathilde Gavillet, Arshed Al-Obeidi, Kate E. Lawlor, James E. Vince, Michelle A. Kelliher, Razq Hakem, Manolis Pasparakis, David A. Williams, Maria Ericsson, Ben A. Croker. http://stke.sciencemag.org/content/11/546/eaao1716

The brace helices of MLKL mediate interdomain communication and oligomerisation to regulate cell death by necroptosis – Katherine A. Davies, Maria C. Tanzer, Michael D. W. Griffin, Yee Foong Mok, Samuel N. Young, Rui Qin, Emma J. Petrie, Peter E. Czabotar, John Silke & James M. Murphy. https://www.nature.com/articles/s41418-018-0061-3


Natural killer cells induce distinct modes of cancer cell death: Discrimination, quantification and modulation of apoptosis, necrosis and mixed forms – Christian S Backes, Kim S Friedmann, Sebastian Mang, Arne Knörck, Markus Hoth and Carsten Kummerow. http://www.jbc.org/content/early/2018/09/06/jbc.RA118.004549.abstract

DPP8/DPP9 inhibitor-induced pyroptosis for treatment of acute myeloid leukemia – Darren C. Johnson, Cornelius Y. Taabazuing, Marian C. Okondo, Ashley J. Chui, Sahana D. Rao, Fiona C. Brown, Casie Reed, Elizabeth Peguero, Elisa de Stanchina, Alex Kentsis & Daniel A. Bachovchin. https://www.nature.com/articles/s41591-018-0082-y

The small GTPase RAB-35 defines a third pathway that is required for the recognition and degradation of apoptotic cells – Ryan Haley, Ying Wang, Zheng Zhou. https://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1007558

Cell-to-Cell Heterogeneity in p38-Mediated Cross-Inhibition of JNK Causes Stochastic Cell Death – Haruko Miura, Yohei Kondo, Michiyuki Matsuda, Kazuhiro Aoki. https://www.cell.com/cell-reports/fulltext/S2211-1247(18)31274-9

Tryparedoxin peroxidase-deficiency commits trypanosomes to ferroptosis-type cell death – Marta Bogacz, R Luise Krauth-Siegel. https://elifesciences.org/articles/37503

BAP1 links metabolic regulation of ferroptosis to tumour suppression – Yilei Zhang, Jiejun Shi, Xiaoguang Liu, Li Feng, Zihua Gong, Pranavi Koppula, Kapil Sirohi, Xu Li, Yongkun Wei, Hyemin Lee, Li Zhuang, Gang Chen, Zhen-Dong Xiao, Mien-Chie Hung, Junjie Chen, Peng Huang, Wei Li & Boyi Gan. https://www.nature.com/articles/s41556-018-0178-0

Gasdermin D Restrains Type I Interferon Response to Cytosolic DNA by Disrupting Ionic Homeostasis – Ishita Banerjee, Bharat Behl, Morena Mendonca, Gaurav Shrivastava, Ashley J. Russo, Antoine Menoret, Arundhati Ghosh, Anthony T. Vella, Sivapriya Kailasan Vanaja, Saumendra N. Sarkar, Katherine A. Fitzgerald, Vijay A.K. Rathinam. https://www.cell.com/immunity/fulltext/S1074-7613(18)30326-1

Dynein links engulfment and execution of apoptosis via CED-4/Apaf1 in C. elegans – Rikke Hindsgaul Harders, Tine Hørning Morthorst, Anna Dippel Lande, Marianne Overgaard Hesselager, Ole Aalund Mandrup, Emøke Bendixen, Allan Stensballe & Anders Olsen. https://www.nature.com/articles/s41419-018-1067-y


Life, death and autophagy – Johnna Doherty & Eric H. Baehrecke. https://www.nature.com/articles/s41556-018-0201-5

Nutrient scavenging in cancer – Brendan T. Finicle, Vaishali Jayashankar & Aimee L. Edinger. https://www.nature.com/articles/s41568-018-0048-x

BCL-2 inhibition in AML: an unexpected bonus? – Marina Konopleva and Anthony Letai. http://bloodjournal.org/content/132/10/1007.abstract?etoc

Apoptosis-Inducing Factor (AIF) in Physiology and Disease: The Tale of a Repented Natural Born Killer – Bano D, Prehn JHM. https://linkinghub.elsevier.com/retrieve/pii/S2352-3964(18)30100-2

Autophagy-dependent cell death – where, how and why a cell eats itself to death – Shani Bialik, Santosh K. Dasari and Adi Kimchi. http://jcs.biologists.org/content/131/18/jcs215152?etoc

Apoptosis and necroptosis in the liver: a matter of life and death – Robert F. Schwabe & Tom Luedd. https://www.nature.com/articles/s41575-018-0065-y

The rise of apoptosis: targeting apoptosis in hematologic malignancies – Rebecca Valentin, Stephanie Grabow and Matthew S. Davids. http://bloodjournal.org/content/132/12/1248.abstract?etoc

The induction and consequences of Influenza A virus-induced cell death – Georgia K. Atkin-Smith, Mubing Duan, Weisan Chen & Ivan K. H. Poon. https://www.nature.com/articles/s41419-018-1035-6


Ion Man: GSDMD Punches Pores to Knock Out cGAS – Rebecca Feltham, James E. Vince. https://www.cell.com/immunity/fulltext/S1074-7613(18)30389-3

Tuning Apoptosis and Neuroinflammation: TBK1 Restrains RIPK1 – Haiyang Yu, Don W. Cleveland. https://www.cell.com/cell/fulltext/S0092-8674(18)31096-1

C. elegans RAB-35: Dual roles in apoptotic cell clearance – Christian E. Rocheleau. https://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1007534

Neighbourhood deaths cause a switch in cancer subtype – Eli Pikarsky. https://www.nature.com/articles/d41586-018-06217-3

Retraction: ROS and CHOP Are Critical for Dibenzylideneacetone to Sensitize Tumor Cells to TRAIL through Induction of Death Receptors and Downregulation of Cell Survival Proteinshttp://cancerres.aacrjournals.org/content/78/17/5185

Metabolic control of ferroptosis in cancer – Michael P. Murphy. https://www.nature.com/articles/s41556-018-0209-x

ApoList – August 2018

Bcl-2 family proteins and MOMP

Mitochondrial inner membrane permeabilisation enables mtDNA release during apoptosis – Joel S Riley, Giovanni Quarato, Catherine Cloix, Jonathan Lopez,Jim O’Prey, Matthew Pearson, James Chapman, Hiromi Sesaki, Leo M Carlin, João F Passos, Ann P Wheeler, Andrew Oberst, Kevin M Ryan, Stephen WG Tait. http://emboj.embopress.org/content/early/2018/07/31/embj.201899238

Systematic mapping of BCL-2 gene dependencies in cancer reveals molecular determinants of BH3 mimetic sensitivity – Ryan S. Soderquist, Lorin Crawford, Esther Liu, Min Lu, Anika Agarwal, Grace R. Anderson, Kevin H. Lin, Peter S. Winter, Merve Cakir & Kris C. Wood. https://www.nature.com/articles/s41467-018-05815-z

Exploiting selective BCL-2 family inhibitors to dissect cell survival dependencies and define improved strategies for cancer therapy – Leverson JD, Phillips DC, Mitten MJ, Boghaert ER, Diaz D, Tahir SK, Belmont LD, Nimmer P, Xiao Y, Ma XM, Lowes KN, Kovar P, Chen J, Jin S, Smith M, Xue J, Zhang H, Oleksijew A, Magoc TJ, Vaidya KS, Albert DH2, Tarrant JM, La N, Wang L, Tao ZF, Wendt MD, Sampath D, Rosenberg SH, Tse C, Huang DC, Fairbrother WJ, Elmore SW, Souers AJ. http://stm.sciencemag.org/content/7/279/279ra40.short

TRIM17 and TRIM28 antagonistically regulate the ubiquitination and anti-apoptotic activity of BCL2A1 – Loïc Lionnard, Pauline Duc, Margs S. Brennan, Andrew J. Kueh, Martin Pal, Francesca Guardia, Barbara Mojsa, Maria-Alessandra Damiano, Stéphan Mora, Iréna Lassot, Ramya Ravichandran, Claude Cochet, Abdel Aouacheria, Patrick Ryan Potts, Marco J. Herold, Solange Desagher & Jérôme Kucharczak. https://www.nature.com/articles/s41418-018-0169-5

Restoring PUMA induction overcomes KRAS-mediated resistance to anti-EGFR antibodies in colorectal cancer – Kyle Knickelbein, Jingshan Tong, Dongshi Chen, Yi-Jun Wang, Sandra Misale, Alberto Bardelli, Jian Yu & Lin Zhang. https://www.nature.com/articles/s41388-018-0289-x

Dual inhibition of BCL-XL and MCL-1 is required to induce tumour regression in lung squamous cell carcinomas sensitive to FGFR inhibition – Clare E. Weeden, Casey Ah-Cann, Aliaksei Z. Holik, Julie Pasquet, Jean-Marc Garnier, Delphine Merino, Guillaume Lessene & Marie-Liesse Asselin-Labat. https://www.nature.com/articles/s41388-018-0268-2

RORγt limits the amount of the cytokine receptor γc through the prosurvival factor Bcl-xLin developing thymocytes – Davinna L. Ligons , SuJin Hwang, Adam T. Waickman, Joo-Young Park, Megan A. Luckey, Jung-Hyun Park. http://stke.sciencemag.org/content/11/545/eaam8939

Death receptors

Confirming a critical role for death receptor 5 and caspase-8 in apoptosis induction by endoplasmic reticulum stress – Mable Lam, David A. Lawrence, Avi Ashkenazi & Peter Walter. https://www.nature.com/articles/s41418-018-0155-y

A Single-Agent Dual-Specificity Targeting of FOLR1 and DR5 as an Effective Strategy for Ovarian Cancer – Gururaj Shivange, Karol Urbanek, Piotr Przanowski, Justin S.A. Perry, James Jones, Robert Haggart, Christina Kostka, Tejal Patki, Edward Stelow, Yuliya Petrova, Danielle Llaneza, Marty Mayo, Kodi S. Ravichandran, Charles N. Landen, Sanchita Bhatnagar, Jogender Tushir-Singh. https://www.cell.com/cancer-cell/fulltext/S1535-6108(18)30310-6

Early activation of CD95 is limited and localized to the cytotoxic synapse – María Florencia Sánchez, Fabronia Murad, Gülce S. Gülcüler Balta, Ana Martin-Villalba, Ana J. García-Sáez and Dolores C. Carrer. https://febs.onlinelibrary.wiley.com/doi/abs/10.1111/febs.14518

Coordination between Two Branches of the Unfolded Protein Response Determines Apoptotic Cell Fate – Tsun-Kai Chang, David A. Lawrence, Min Lu, Jenille Tan, Jonathan M. Harnoss, Scot A. Marsters, Peter Liu, Wendy Sandoval, Scott E. Martin, Avi Ashkenazi. https://www.cell.com/molecular-cell/fulltext/S1097-2765(18)30513-6


HSP90 inhibition targets autophagy and induces a CASP9-dependent resistance mechanism in NSCLC – Jie Han, Leslie A. Goldstein, Wen Hou, Suman Chatterjee, Timothy F. Burns & Hannah Rabinowich. https://www.tandfonline.com/doi/full/10.1080/15548627.2018.1434471

Necroptosis / RIPK

Biallelic RIPK1 mutations in humans cause severe immunodeficiency, arthritis, and intestinal inflammation – Delphine Cuchet-Lourenço, Davide Eletto, Changxin Wu, Vincent Plagnol, Olivier Papapietro, James Curtis, Lourdes Ceron-Gutierrez, Chris M. Bacon, Scott Hackett, Badr Alsaleem, Mailis Maes, Miguel Gaspar, Ali Alisaac, Emma Goss, Eman AlIdrissi, Daniela Siegmund, Harald Wajant, Dinakantha Kumararatne, Mofareh S. AlZahrani, Peter D. Arkwright, Mario Abinun, Rainer Doffinger, Sergey Nejentsev. http://science.sciencemag.org/content/361/6404/810

Kinase domain dimerization drives RIPK3-dependent necroptosis – Saravanan Raju , Daniel M. Whalen, Meron Mengistu, Carter Swanson, John G. Quinn, Susan S. Taylor, Joshua D. Webster, Kim Newton, Andrey S. Shaw. http://stke.sciencemag.org/content/11/544/eaar2188

Neuroprotective Effects of DTIO, A Novel Analog of Nec-1, in Acute and Chronic Stages After Ischemic Stroke – Li W, Liu J, Chen JR, Zhu YM, Gao X, Ni Y, Lin B, Li H, Qiao SG, Wang C, Zhang HL, Ao GZ. https://www.sciencedirect.com/science/article/abs/pii/S0306452218305190

RIPK1–RIPK3–MLKL-Associated Necroptosis Drives Leishmania infantum Killing in Neutrophils – Laiana Arlego-Barbosa, Paloma Peixoto Fiuza, Letícia Jambeiro Borges, Fillipe dosAnjos Rolim, Mayara Borges Andrade, Nivea F Luz, Graziele Quintela-Carvalho, Jonilson Berlink Lima, Roque P. Almeida, Francis Kaming Chan, Marcelo Torres Bozza, Valeria M Borges, Deboraci Brito Prates. https://www.frontiersin.org/articles/10.3389/fimmu.2018.01818/full

Treatment with mRNA coding for the necroptosis mediator MLKL induces antitumor immunity directed against neo-epitopes – Lien Van Hoecke, Sandra Van Lint, Kenny Roose, Alexander Van Parys, Peter Vandenabeele, Johan Grooten, Jan Tavernier, Stefaan De Koker & Xavier Saelens. https://www.nature.com/articles/s41467-018-05979-8

Gasdermin D, pyroptosis

Chemical disruption of the pyroptotic pore-forming protein gasdermin D inhibits inflammatory cell death and sepsis [necrosulfonamide is a Gasdermin D inhibitor] – Joseph K. Rathkey, Junjie Zhao, Zhonghua Liu, Yinghua Chen, Jie Yang, Hannah C. Kondolf, Bryan L. Benson, Steven M. Chirieleison, Alex Y. Huang, George R. Dubyak, Tsan S. Xiao, Xiaoxia Li, Derek W. Abbott. http://immunology.sciencemag.org/content/3/26/eaat2738.full

Noncanonical inflammasome signaling elicits gasdermin D–dependent neutrophil extracellular traps – Kaiwen W. Chen, Mercedes Monteleone, Dave Boucher, Gabriel Sollberger, Divya Ramnath, Nicholas D. Condon, Jessica B. von Pein, Petr Broz, Matthew J. Sweet, Kate Schroder. http://immunology.sciencemag.org/content/3/26/eaar6676

Gasdermin D plays a vital role in the generation of neutrophil extracellular traps – Gabriel Sollberger, Axel Choidas, Garth Lawrence Burn, Peter Habenberger, Raffaella Di Lucrezia, Susanne Kordes, Sascha Menninger, Jan Eickhoff, Peter Nussbaumer, Bert Klebl, Renate Krüger, Alf Herzig, Arturo Zychlinsky. http://immunology.sciencemag.org/content/3/26/eaar6689

Interleukin-1β Maturation Triggers Its Relocation to the Plasma Membrane for Gasdermin-D-Dependent and -Independent Secretion – Mercedes Monteleone, Amanda C. Stanley, Kaiwen W. Chen, Darren L. Brown, Jelena S. Bezbradica, Jessica B. von Pein, Caroline L. Holley, Dave Boucher, Melanie R. Shakespear, Ronan Kapetanovic, Verena Rolfes, Matthew J. Sweet, Jennifer L. Stow, Kate Schroder. https://www.cell.com/cell-reports/fulltext/S2211-1247(18)31117-3

Other forms of cell death

AMPK-Mediated BECN1 Phosphorylation Promotes Ferroptosis by Directly Blocking System Xc – Activity – Xinxin Song, Shan Zhu, Pan Chen, Wen Hou, Qirong Wen, Jiao Liu, Yangchun Xie, Jinbao Liu, Daniel J. Klionsky, Guido Kroemer, Michael T. Lotze, Herbert J. Zeh, Rui Kang, Daolin Tang. https://www.cell.com/current-biology/fulltext/S0960-9822(18)30764-4

Programmed cell removal by calreticulin in tissue homeostasis and cancer – Mingye Feng, Kristopher D. Marjon, Fangfang Zhu, Rachel Weissman-Tsukamoto, Aaron Levett, Katie Sullivan, Kevin S. Kao, Maxim Markovic, Paul A. Bump, Hannah M. Jackson, Timothy S. Choi, Jing Chen, Allison M. Banuelos, Jie Liu, Phung Gip, Lei Cheng, Denong Wang & Irving L. Weissman. https://www.nature.com/articles/s41467-018-05211-7

Genomic instability in mutant p53 cancer cells upon entotic engulfment – Hannah L. Mackay, David Moore, Callum Hall, Nicolai J. Birkbak, Mariam Jamal-Hanjani, Saadia A. Karim, Vinaya M. Phatak, Lucia Piñon, Jennifer P. Morton, Charles Swanton, John Le Quesne & Patricia A. J. Muller. https://www.nature.com/articles/s41467-018-05368-1


Cholesterol impairs autophagy-mediated clearance of amyloid beta while promoting its secretion – Elisabet Barbero-Camps, Vicente Roca-Agujetas, Isabel Bartolessis, Cristina de Dios, Jose C. Fernández-Checa, Montserrat Marí, Albert Morales, Tobias Hartmann & Anna Colell. https://www.tandfonline.com/doi/full/10.1080/15548627.2018.1438807#metrics-content

Activation of the apoptotic pathway during prolonged prometaphase blocks daughter cell proliferation – Yumi Uetake and Greenfield Sluder. https://www.molbiolcell.org/doi/abs/10.1091/mbc.E18-01-0026

Perforin proteostasis is regulated through its C2 domain: supra-physiological cell death mediated by T431D-perforin – Amelia J. Brennan, Ruby H. P. Law, Paul J. Conroy, Tahereh Noori, Natalya Lukoyanova, Helen Saibil, Hideo Yagita, Annette Ciccone, Sandra Verschoor, James C. Whisstock, Joseph A. Trapani & Ilia Voskoboinik. https://www.nature.com/articles/s41418-018-0057-z

Reviews / comments

RIP kinases as modulators of inflammation and immunity – Sudan He & Xiaodong Wang. https://www.nature.com/articles/s41590-018-0188-x

Ripk1 and haematopoiesis: a case for LUBAC and Ripk3 – Alessandro Annibaldi & Pascal Meier. https://www.nature.com/articles/s41418-018-0135-2

Different apoptosis pathways in Leishmania parasites – Louise Basmaciyan, Nadine Azas & Magali Casanova. https://www.nature.com/articles/s41420-018-0092-z


ApoList – July 2018


Bcl-2 family proteins

Statins enhance efficacy of venetoclax in blood cancers – J. Scott Lee, Andrew Roberts, Dennis Juarez, Thanh-Trang T. Vo, Shruti Bhatt, Lee-or Herzog, Sharmila Mallya, Richard J. Bellin, Suresh K. Agarwal, Ahmed Hamed Salem, Tu Xu, Jia Jia, Lingxiao Li, John R. Hanna, Matthew S. Davids, Angela G. Fleischman, Susan O’Brien, Lloyd T. Lam, Joel D. Leverson, Anthony Letai, Jonathan H. Schatz and David A. Fruman



Intrinsic apoptosis circumvents the functional decline of circulating platelets but does not cause the storage lesion – Irina Pleines, Marion Lebois, Pradnya Gangatirkar, Amanda E. Au, Rachael M. Lane, Katya J. Henley, Maria Kauppi, Jason Corbin, Ping Cannon, Jonathan Bernardini, Imala Alwis, Kate E. Jarman, Sarah Ellis, Donald Metcalf, Shaun P. Jackson, Simone M. Schoenwaelder, Benjamin T. Kile and Emma C. Josefsson



DNA repair processes are critical mediators of p53-dependent tumor suppression – Ana Janic, Liz J. Valente, Matthew J. Wakefield, Leon Di Stefano, Liz Milla, Stephen Wilcox, Haoyu Yang, Lin Tai, Cassandra J. Vandenberg, Andrew J. Kueh, Shinsuke Mizutani, Margs S. Brennan, Robyn L. Schenk, Lisa M. Lindqvist, Anthony T. Papenfuss, Liam O’Connor, Andreas Strasser & Marco J. Herold



Phosphorylation alters Bim-mediated Mcl-1 stabilization and priming – Jason E. Conage-Pough and Lawrence H. Boise



Low cleaved caspase-7 levels indicate unfavourable outcome across all breast cancers [and low Bcl-2] – Lindner AU, Lucantoni F, Varešlija D, Resler A, Murphy BM, Gallagher WM, Hill ADK, Young LS, Prehn JHM.


Death receptors

Confirming a critical role for death receptor 5 and caspase-8 in apoptosis induction by endoplasmic reticulum stress – David Lawrence, Avi Ashkenazi & Peter Walter



Fas-L promotes the stem cell potency of adipose-derived mesenchymal cells – Inna Solodeev, Benjamin Meilik, Ilan Volovitz, Meirav Sela, Sharon Manheim, Shai Yarkoni, Dov Zipori, Eyal Gur & Nir Shani



Hypertonicity-enforced BCL-2 addiction unleashes the cytotoxic potential of death receptors – Simon Sirtl, Gertrud Knoll, Dieu Thuy Trinh, Isabell Lang, Daniela Siegmund, Stefanie Gross, Beatrice Schuler-Thurner, Patrick Neubert, Jonathan Jantsch, Harald Wajant & Martin Ehrenschwender



Phenotypic screening identifies a new oxazolone inhibitor of necroptosis and neuroinflammation – Sara R. Oliveira, Pedro A. Dionísio, Hugo Brito, Lídia Franco, Catarina A. B. Rodrigues, Rita C. Guedes, Carlos A. M. Afonso, Joana D. Amaral & Cecília M. P. Rodrigues


Caspases and IAPs

Caspase-8 Collaborates with Caspase-11 to Drive Tissue Damage and Execution of Endotoxic Shock – Pratyusha Mandal, Yanjun Feng, John D. Lyons, Scott B. Berger, Shunsuke Otani, Alexandra DeLaney, Gregory K. Tharp, Kristal Maner-Smith, Eileen M. Burd, Michelle Schaeffer, Sandra Hoffman, Carol Capriotti, Linda Roback, Cedrick B. Young, Zhe Liang, Eric A. Ortlund, Nelson C. DiPaolo, Steven Bosinger, John Bertin, Peter J. Gough, Igor E. Brodsky, Craig M. Coopersmith, Dmitry M. Shayakhmetov, Edward S. Mocarski



Dimer‐specific immunoprecipitation of active caspase‐2 identifies TRAF proteins as novel activators – Alexander C Robeson, Kelly R Lindblom, Jeffrey Wojton, Sally Kornbluth and Kenkyo Matsuura



Differential susceptibility of striatal, hippocampal and cortical neurons to Caspase-6 – Anastasia Noël, Libin Zhou, Bénédicte Foveau, P. Jesper Sjöström & Andréa C. LeBlanc



Unique BIR domain sets determine inhibitor of apoptosis protein–driven cell death and NOD2 complex signal specificity – Steven M. Chirieleison, Joseph K. Rathkey, Derek W. Abbott



XAF1 forms a positive feedback loop with IRF-1 to drive apoptotic stress response and suppress tumorigenesis – Seong-In Jeong, Jung-Wook Kim, Kyung-Phil Ko, Byung-Kyu Ryu, Min-Goo Lee



Low cleaved caspase-7 levels indicate unfavourable outcome across all breast cancers – Lindner AU, Lucantoni F, Varešlija D, Resler A, Murphy BM, Gallagher WM, Hill ADK, Young LS, Prehn JHM.


Execution phase and post-mortem

Apoptotic Cell-Derived Extracellular Vesicles Promote Malignancy of Glioblastoma Via Intercellular Transfer of Splicing Factors – Marat S. Pavlyukov, Hai Yu, Soniya Bastola, Mutsuko Minata, Victoria O. Shender, Yeri Lee, Suojun Zhang, Jia Wang, Svetlana Komarova, Jun Wang, Shinobu Yamaguchi, Heba Allah Alsheikh, Junfeng Shi, Dongquan Chen, Ahmed Mohyeldin, Sung-Hak Kim, Yong Jae Shin, Ksenia Anufrieva, Evgeniy G. Evtushenko, Nadezhda V. Antipova, Georgij P. Arapidi, Vadim Govorun, Nikolay B. Pestov, Mikhail I. Shakhparonov, L. James Lee, Do-Hyun Nam, Ichiro Nakano



Staurosporine-induced apoptotic water loss is cell- and attachment-specific – Michael A. Model, Nathan J. Mudrak, Priyanka S. Rana, Robert J. Clements



Competition for Space Is Controlled by Apoptosis-Induced Change of Local Epithelial Topology – Alice Tsuboi, Shizue Ohsawa, Daiki Umetsu, Yukari Sando, Erina Kuranaga, Tatsushi Igaki, Koichi Fujimoto



NAD+ Depletion Triggers Macrophage Necroptosis, a Cell Death Pathway Exploited by Mycobacterium tuberculosis – David Pajuelo, Norberto Gonzalez-Juarbe, Uday Tak, Jim Sun, Carlos J. Orihuela, Michael Niederweis



Necroptosis promotes autophagy-dependent upregulation of DAMP and results in immunosurveillance – Sheng-Yen Lin, Sung-Yuan Hsieh, Yi-Ting Fan, Wen-Chi Wei, Pei-Wen Hsiao, Dai-Hua Tsai, Tzong-Shoon Wu & Ning-Sun Yang



Activated platelets induce MLKL-driven neutrophil necroptosis and release of neutrophil extracellular traps in venous thrombosis – Daigo Nakazawa, Jyaysi Desai, Stefanie Steiger, Susanne Müller, Satish Kumar Devarapu,   Shrikant R. Mulay, Takamasa Iwakura & Hans-Joachim Anders



Phenotypic screening identifies a new oxazolone inhibitor of necroptosis and neuroinflammation – Sara R. Oliveira, Pedro A. Dionísio, Hugo Brito, Lídia Franco, Catarina A. B. Rodrigues, Rita C. Guedes, Carlos A. M. Afonso, Joana D. Amaral & Cecília M. P. Rodrigues



Nano-targeted induction of dual ferroptotic mechanisms eradicates high-risk neuroblastoma – Behrouz Hassannia, Bartosz Wiernicki, Irina Ingold, Feng Qu, Simon Van Herck, Yulia Y. Tyurina, Hülya Bayır, Behnaz A. Abhari, Jose Pedro Friedmann Angeli, Sze Men Choi, Eline Meul, Karen Heyninck, Ken Declerck, Chandra Sekhar Chirumamilla, Maija Lahtela-Kakkonen, Guy Van Camp, Dmitri V. Krysko, Paul G. Ekert, Simone Fulda, Bruno G. De Geest, Marcus Conrad, Valerian E. Kagan, Wim Vanden Berghe, Peter Vandenabeele, and Tom Vanden Berghe



Mechanism of membrane pore formation by human gasdermin‐D – Estefania Mulvihill, Lorenzo Sborgi, Stefania A Mari, Moritz Pfreundschuh, Sebastian Hiller and Daniel J Müller



Comment on “Sterilizing immunity in the lung relies on targeting fungal apoptosis-like programmed cell death” – Abdel Aouacheria,  Kyle W. Cunningham, J. Marie Hardwick, Zdena Palková, Ted Powers, Fedor F. Severin, Libuše Váchová



Response to Comment on “Sterilizing immunity in the lung relies on targeting fungal apoptosis-like programmed cell death” – Neta Shlezinger, Henriette Irmer, Sourabh Dhingra, Sarah R. Beattie, Robert A. Cramer, Gerhard H. Braus, Amir Sharon, Tobias M. Hohl



Programmed Cell Death in Immune Defense: Knowledge and Presumptions – David Wallach, Tae-Bong Kang



New insights into apoptosome structure and function – Loretta Dorstyn, Christopher W. Akey & Sharad Kumar



Do Fungi Undergo Apoptosis-Like Programmed Cell Death? – J. Marie Hardwick


Comments / other

Gut check: dead cell samples leads to tolerant examples – Thomas H Oguin III & Jennifer Martinez



Growing a gasdermin pore in membranes of pyroptotic cells – Jingjin Ding and Feng Shao



Q & A – Karen Vousden



Finding clues in the p53 maze: an interview with Karen Vousden



Jerry Chipuk: A powerhouse for mitochondrial biology


ApoList – June 2018

Death receptors

Regulation of a distinct activated RIPK1 intermediate bridging complex I and complex II in TNFα-mediated apoptosis
Palak Amin, Marcus Florez, Ayaz Najafov, Heling Pan, Jiefei Geng, Dimitry Ofengeim, Slawomir A. Dziedzic, Huibing Wang, Vica Jean Barrett, Yasushi Ito, Matthew J. LaVoie, and Junying Yuan

A Drosophila Tumor Suppressor Gene Prevents Tonic TNF Signaling through Receptor N-Glycosylation
Geert de Vreede, Holly A. Morrison, Alexandra M. Houser, Ryan M. Boileau, Ditte Andersen, Julien Colombani, David Bilder

TRAIL mediates and sustains constitutive NF-κB activation in LGL leukemia
Jun Yang, Francis R. LeBlanc, Shubha A. Dighe, Cait E. Hamele, Thomas L. Olson, David J. Feith and Thomas P. Loughran Jr

Monocyte chemotactic protein-induced protein-1 enhances DR5 degradation and negatively regulates DR5 activation-induced apoptosis through its deubiquitinase function
You-Take Oh, Guoqing Qian, Jiusheng Deng & Shi-Yong Sun

Dose intensification of TRAIL-inducing ONC201 inhibits metastasis and promotes intratumoral NK cell recruitment
Jessica Wagner, C. Leah Kline, Lanlan Zhou, Kerry S. Campbell, Alexander W. MacFarlane, Anthony J. Olszanski, Kathy Q. Cai, Harvey H. Hensley, Eric A. Ross, Marie D. Ralff, Andrew Zloza, Charles B. Chesson, Jenna H. Newman, Howard Kaufman, Joseph Bertino, Mark Stein, and Wafik S. El-Deiry

Matias Eliseo Melendez, Renato José Silva-Oliveira, Anna Luiza Silva Almeida Vicente, Lidia Maria Rebolho Batista Arantes, Ana Carolina de Carvalho, Alberto Luis Epstein, Rui Manuel Reis, and André Lopes Carvalho

Transmembrane TNF-alpha promotes chemoresistance in breast cancer cells
Zunyue Zhang, Guohong Lin, Yujing Yan, Xiang Li, Yibing Hu, Jing Wang, Bingjiao Yin, Yaqun Wu, Zhuoya Li & Xiang-Ping Yang

OTULIN limits cell death and inflammation by deubiquitinating LUBAC
Klaus Heger, Katherine E. Wickliffe, Ada Ndoja, Juan Zhang, Aditya Murthy, Debra L. Dugger, Allie Maltzman, Felipe de Sousa e Melo, Jeffrey Hung, Yi Zeng, Erik Verschueren, Donald S. Kirkpatrick, Domagoj Vucic, Wyne P. Lee, Merone Roose-Girma, Robert J. Newman, Søren Warming, Yi-Chun Hsiao, László G. Kőműves, Joshua D. Webster, Kim Newton & Vishva M. Dixit

Fas ligand promotes an inducible TLR-dependent model of cutaneous lupus–like inflammation
Purvi Mande, Bahar Zirak, Wei-Che Ko, Keyon Taravati, Karen L. Bride, Tia Y. Brodeur, April Deng, Karen Dresser, Zhaozhao Jiang, Rachel Ettinger, Katherine A. Fitzgerald, Michael D. Rosenblum, John E. Harris, and Ann Marshak-Rothstein

Caspases and IAPs

Caspase-8 deficiency in mouse embryos triggers chronic RIPK1-dependent activation of inflammatory genes, independently of RIPK3
Tae-Bong Kang, Ju-Seong Jeong, Seung-Hoon Yang, Andrew Kovalenko & David Wallach

Phosphorylation by protein kinase A disassembles the caspase-9 core
Banyuhay P. Serrano & Jeanne A. Hardy

A proximity-dependent biotinylation (BioID) approach flags the p62/sequestosome-1 protein as a caspase-1 substrate
Yvan Jamilloux, Brice Lagrange, Antonia Di MIcco, Emilie Bourdonnay, Angélina Provost, Rémy Tallant, Thomas Henry and Fabio Martinon

Stimulator of interferon genes (STING) provides insect antiviral immunity by promoting Dredd caspase–mediated NF-kB activation
Xiaoting Hua, Binbin Li, Liang Song, Cuimei Hu, Xianyang Li, Dandan Wang, Ying Xiong, Ping Zhao, Huawei He, Qingyou xia and Fei Wang

Phosphorylation of XIAP at threonine 180 controls its activity in Wnt signaling
Victoria H. Ng, Brian I. Hang, Leah M. Sawyer, Leif R. Neitzel, Emily E. Crispi, Kristie L. Rose, Tessa M. Popay, Alison Zhong, Laura A. Lee, William P. Tansey, Stacey Huppert and Ethan Lee

Differentiated Macrophages Acquire a Pro-Inflammatory and Cell Death-Resistant Phenotype Due to Increasing XIAP and P38-mediated inhibition of RipK1
Dikchha Rijal, Ardeshir Ariana, Andrew Wight, Kwangsin Kim, Norah A. Alturki, Zoya Aamir, Emmanuelle Ametepe, Robert G. Korneluk, Christopher Tiedje, Manoj B Menon, Matthias Gaestel, Scott McComb and Subash Sad

Anke Rauch, Annemarie Carlstedt, Claudia Emmerich, Al-Hassan M. Mustafa, Anja Göder, Shirley K. Knauer,Michael Linnebacher, Thorsten Heinzel, and Oliver H. Krämer

Bcl-2 family proteins

The ribosomal RPL10 R98S mutation drives IRES-dependent BCL-2 translation in T-ALL
Kim R. Kampen, Sergey O. Sulima, Benno Verbelen, Tiziana Girardi, Stijn Vereecke, Gianmarco Rinaldi, Jelle Verbeeck, Joyce Op de Beeck, Anne Uyttebroeck, Jules P. P. Meijerink, Anthony V. Moorman, Christine J. Harrison, Pieter Spincemaille, Jan Cools, David Cassiman, Sarah-Maria Fendt, Pieter Vermeersch & Kim De Keersmaecker

BH4 domain peptides derived from Bcl-2/Bcl-XL as novel tools against acute pancreatitis
Tim Vervliet, Julia V. Gerasimenko, Pawel E. Ferdek, Monika A. Jakubowska, Ole H. Petersen, Oleg V. Gerasimenko & Geert Bultynck

miR-339 Promotes Development of Stem Cell Leukemia/Lymphoma Syndrome via Downregulation of the BCL2L11 [Bim] and BAX Proapoptotic Genes
Tianxiang Hu, Yating Chong, Sumin Lu, Rebecca Wang, Haiyan Qin, Jeane Silva, Eiko Kitamura, Chang-Sheng Chang, LesleyAnn Hawthorn and John K. Cowell


Conformational switching of the pseudokinase domain promotes human MLKL tetramerization and cell death by necroptosis
Emma J. Petrie, Jarrod J. Sandow, Annette V. Jacobsen, Brian J. Smith, Michael D. W. Griffin, Isabelle S. Lucet, Weiwen Dai, Samuel N. Young, Maria C. Tanzer, Ahmad Wardak, Lung-Yu Liang, Angus D. Cowan, Joanne M. Hildebrand, Wilhelmus J. A. Kersten, Guillaume Lessene, John Silke, Peter E. Czabotar, Andrew I. Webb & James M. Murphy

PELI1 Selectively Targets Kinase-Active RIP3 for Ubiquitylation-Dependent Proteasomal Degradation
Seung-Won Choi, Han-Hee Park, Soyeon Kim, Jee Min Chung, Hyun-Jin Noh, Sue Kyung Kim, Hyun Kyu Song, Chang-Woo Lee, Michael J. Morgan, Ho Chul Kang, You-Sun Kim

MLKL Requires the Inositol Phosphate Code to Execute Necroptosis
Cole M. Dovey, Jonathan Diep, Bradley P. Clarke, Andrew T. Hale, Dan E. McNamara, Hongyan Guo, Nathaniel W. Brown Jr., Jennifer Yinuo Cao, Christy R. Grace, Peter J. Gough, John Bertin, Scott J. Dixon, Dorothea Fiedler, Edward S. Mocarski, William J. Kaiser, Tudor Moldoveanu, John D. York, Jan E. Carette

Mutant p53-Expressing Cells Undergo Necroptosis via Cell Competition with the Neighboring Normal Epithelial Cells
Hirotaka Watanabe, Kojiro Ishibashi, Hiroki Mano, Sho Kitamoto, Nanami Sato, Kazuya Hoshiba, Mugihiko Kato, Fumihiko Matsuzawa, Yasuto Takeuchi, Takanobu Shirai, Susumu Ishikawa, Yuka Morioka, Toshiaki Imagawa, Kazuyasu Sakaguchi, Suguru Yonezawa, Shunsuke Kon, Yasuyuki Fujita

Inhibition of Programmed Necrosis Limits Infarct Size through Altered Mitochondrial and Immune Responses in the Aged Female Rat Heart.
Garvin AM1, Jackson MA2, Korzick DH

Hyperglycemia potentiates a shift from apoptosis to RIP1-dependent necroptosis
William D. McCaig, Payal S. Patel, Sergey A. Sosunov, Nicole L. Shakerley, Tori A. Smiraglia, Miranda M. Craft, Katharine M. Walker, Matthew A. Deragon, Vadim S. Ten & Timothy J. LaRocca

Pyroptosis, ferroptosis and other -osis

Mechanism of gasdermin D recognition by inflammatory caspases and their inhibition by a gasdermin D-derived peptide inhibitor
Jie Yang, Zhonghua Liu, Chuanping Wang, Rui Yang, Joseph K. Rathkey, Otis W. Pinkard, Wuxian Shi, Yinghua Chen, George R. Dubyak, Derek W. Abbott, and Tsan Sam Xiao

GSDMD is critical for autoinflammatory pathology in a mouse model of Familial Mediterranean Fever
Apurva Kanneganti, R.K. Subbarao Malireddi, Pedro H.V. Saavedra, Lieselotte Vande Walle, Hanne Van Gorp, Hiroto Kambara, Heather Tillman, Peter Vogel, Hongbo R. Luo, Ramnik J. Xavier, Hongbo Chi and Mohamed Lamkanfi

Caspase-1 inhibition prevents glial inflammasome activation and pyroptosis in models of multiple sclerosis
Brienne A. McKenzie, Manmeet K. Mamik, Leina B. Saito, Roobina Boghozian, Maria Chiara Monaco, Eugene O. Major, Jian-Qiang Lu, William G. Branton, and Christopher Power

Increased erythrophagocytosis induces ferroptosis in red pulp macrophages in a mouse model of transfusion
Lyla A. Youssef, Abdelhadi Rebbaa, Sergey Pampou, Stuart P. Weisberg, Brent R. Stockwell, Eldad A. Hod and Steven L. Spitalnik

Neutrophils Kill Antibody-Opsonized Cancer Cells by Trogoptosis
Hanke L. Matlung, Liane Babes, Xi Wen Zhao, Michel van Houdt, Louise W. Treffers, Dieke J. van Rees, Katka Franke, Karin Schornagel, Paul Verkuijlen, Hans Janssen, Pasi Halonen, Cor Lieftink, Roderick L. Beijersbergen, Jeanette H.W. Leusen, Jaap J. Boelens, Ingrid Kuhnle, Jutte van der Werff Ten Bosch, Karl Seeger, Sergio Rutella, Daria Pagliara, Takashi Matozaki, Eiji Suzuki, Catharina Willemien Menke-van der Houven van Oordt, Robin van Bruggen, Dirk Roos, Rene A.W. van Lier, Taco W. Kuijpers, Paul Kubes, Timo K. van den Berg


Local apoptotic-like mechanisms underlie complement-mediated synaptic pruning
Balázs A. Györffy, Judit Kun, György Török, Éva Bulyáki, Zsolt Borhegyi, Péter Gulyássy, Viktor Kis, Péter Szocsics, András Micsonai, János Matkó, László Drahos, Gábor Juhász, Katalin A. Kékesi, and József Kardos


XIAP at the crossroads of cell death and inflammation
Domagoj Vucic

Unsolved mysteries: How does lipid peroxidation cause ferroptosis?
Huizhong Feng, Brent R. Stockwell

Caspases in metabolic disease and their therapeutic potential
Claire H Wilson & Sharad Kumar

Beyond Cell Death: New Functions for TNF Family Cytokines in Autoimmunity and Tumor Immunotherapy
Fei Yi, Nicholas Frazzette, Anthony C. Cruz, Christopher A. Klebanoff, Richard M. Siegel