Caspases
Caspase-7 activates ASM to repair gasdermin and perforin pores – Kengo Nozaki, Vivien I. Maltez, Manira Rayamajhi, Alan L. Tubbs, Joseph E. Mitchell, Carolyn A. Lacey, Carissa K. Harvest, Lupeng Li, William T. Nash, Heather N. Larson, Benjamin D. McGlaughon, Nathaniel J. Moorman, Michael G. Brown, Jason K. Whitmire and Edward A. Miao. https://www.nature.com/articles/s41586-022-04825-8
Caspase‐8 in endothelial cells maintains gut homeostasis and prevents small bowel inflammation in mice – Nathalie Tisch, Carolin Mogler, Ana Stojanovic, Robert Luck, Emilia A Korhonen, Alexander Ellerkmann, Heike Adler, Mahak Singhal, Géza Schermann, Lena Erkert, Jay V Patankar, Andromachi Karakatsani, Anna-Lena Scherr, Yaron Fuchs, Adelheid Cerwenka, Stefan Wirtz, Bruno Christian Köhler, Hellmut G Augustin, Christoph Becker, Thomas Schmidt, Carmen Ruiz de Almodóvar. https://www.embopress.org/doi/full/10.15252/emmm.202114121
Myeloid caspase-8 restricts RIPK3-dependent proinflammatory IL-1β production and CD4 T cell activation in autoimmune demyelination – Sunja Kim, Hsueh Chung Lu, Andrew J. Steelman and Jianrong Li. https://www.pnas.org/doi/10.1073/pnas.2117636119
Cytoplasmic innate immune sensing by the caspase-4 non-canonical inflammasome promotes cellular senescence – Irene Fernández-Duran, Andrea Quintanilla, Núria Tarrats, Jodie Birch, Priya Hari, Fraser R. Millar, Anthony B. Lagnado, Vanessa Smer-Barreto, Morwenna Muir, Valerie G. Brunton, João F. Passos and Juan Carlos Acosta. https://www.nature.com/articles/s41418-021-00917-6
Mechanistic insights into the activation of the IKK kinase complex by the Kaposi’s sarcoma herpes virus oncoprotein vFLIP – Claire Bagnéris, Swathi L. Senthil Kumar, Mehdi Baratchian, Hannah M. Britt, Tufa E. Assafa, Konstantinos Thalassinos, Mary K. Collins, Tracey E. Barrett. https://www.jbc.org/article/S0021-9258(22)00452-5/fulltext
Necroptosis
Human RIPK3 C-lobe phosphorylation is essential for necroptotic signaling – Yanxiang Meng, Christopher R. Horne, Andre L. Samson, Laura F. Dagley, Samuel N. Young, Jarrod J. Sandow, Peter E. Czabotar and James M. Murphy. https://www.nature.com/articles/s41419-022-05009-y
Pyroptosis
Nanobodies dismantle post‐pyroptotic ASC specks and counteract inflammation in vivo – Damien Bertheloot, Carlos WS Wanderley, Ayda H Schneider, Lisa DJ Schiffelers, Jennifer D Wuerth, Jan MP Tödtmann, Salie Maasewerd, Ibrahim Hawwari, Fraser Duthie, Cornelia Rohland, Lucas S Ribeiro, Lea-Marie Jenster, Nathalia Rosero, Yonas M Tesfamariam, Fernando Q Cunha, Florian I Schmidt, Bernardo S Franklin. https://www.embopress.org/doi/full/10.15252/emmm.202115415
Targeting of GSDMD sensitizes HCC to anti-PD-1 by activating cGAS pathway and downregulating PD-L1 expression – Tingting Lv, Xiaofeng Xiong, Wei Yan, Mei Liu, Hongwei Xu and Qin He. https://jitc.bmj.com/content/10/6/e004763
Ferroptosis
Cancer cells dying from ferroptosis impede dendritic cell-mediated anti-tumor immunity – Bartosz Wiernicki, Sophia Maschalidi, Jonathan Pinney, Sandy Adjemian, Tom Vanden Berghe, Kodi S. Ravichandran and Peter Vandenabeele. https://www.nature.com/articles/s41467-022-31218-2
Ferroptosis mediates selective motor neuron death in amyotrophic lateral sclerosis – Taide Wang, Doris Tomas, Nirma D. Perera, Brittany Cuic, Sophia Luikinga, Aida Viden, Samantha K. Barton, Catriona A. McLean, André L. Samson, Adam Southon, Ashley I. Bush, James M. Murphy and Bradley J. Turner. https://www.nature.com/articles/s41418-021-00910-z
A ferroptosis defense mechanism mediated by glycerol-3-phosphate dehydrogenase 2 in mitochondria – Shiqi Wu, Chao Mao, Lavanya Kondiparthi, Masha V. Poyurovsky, Kellen Olszewski and Boyi Gan. https://www.pnas.org/doi/10.1073/pnas.2121987119
Miscellanous
Optogenetic activators of apoptosis, necroptosis, and pyroptosis – Kateryna Shkarina, Eva Hasel de Carvalho, José Carlos Santos, Saray Ramos, Maria Leptin, Petr Broz. https://rupress.org/jcb/article/221/6/e202109038/213145
DRP1 levels determine the apoptotic threshold during embryonic differentiation through a mitophagy-dependent mechanism – Barbara Pernaute, Salvador Pérez-Montero, Juan Miguel Sánchez Nieto, Aida Di Gregorio, Ana Lima, Katerina Lawlor, Sarah Bowling, Gianmaria Liccardi, Alejandra Tomás, Pascal Meier, Hiromi Sesaki, Guy A. Rutter, Ivana Barbaric, Tristan A. Rodríguez. https://www.cell.com/developmental-cell/fulltext/S1534-5807(22)00306-9
A signature for pan-cancer prognosis based on neutrophil extracellular traps – Yi Zhang, Liping Guo, Qichen Dai, Bingqing Shang, Ting Xiao, Xuebing Di, Kaitai Zhang, Lin Feng, Jianzhong Shou and Yipeng Wang. https://jitc.bmj.com/content/10/6/e004210
TIR domains of plant immune receptors are 2′,3′-cAMP/cGMP synthetases mediating cell death – Dongli Yu, Wen Song, Eddie Yong Jun Tan, Li Liu, Yu Cao, Jan Jirschitzka, Ertong Li, Elke Logemann, Chenrui Xu, Shijia Huang, Aolin Jia, Xiaoyu Chang, Zhifu Han, Bin Wu, Paul Schulze-Lefert, Jijie Chai. https://www.cell.com/cell/fulltext/S0092-8674(22)00530-X
Reviews
What can we learn from mice lacking pro-survival BCL-2 proteins to advance BH3 mimetic drugs for cancer therapy? – Kerstin Brinkmann, Ashley P. Ng, Carolyn A. de Graaf and Andreas Strasser. https://www.nature.com/articles/s41418-022-00987-0
Paradoxical roles of caspase-3 in regulating cell survival, proliferation, and tumorigenesis – Ebrahim Eskandari, Connie J. Eaves. https://rupress.org/jcb/article/221/6/e202201159/213213
Structural Details of BH3 Motifs and BH3-Mediated Interactions: an Updated Perspective – Valentina Sora and Elena Papaleo. https://www.frontiersin.org/articles/10.3389/fmolb.2022.864874/full
Ferroptosis at the intersection of lipid metabolism and cellular signaling – Deguang Liang, Alexander M. Minikes, Xuejun Jiang. https://www.cell.com/molecular-cell/fulltext/S1097-2765(22)00260-X
Cell Death-Related Ubiquitin Modifications in Inflammatory Syndromes: From Mice to Men – Nieves Peltzer and Alessandro Annibaldi. https://www.mdpi.com/2227-9059/10/6/1436
Comments
Killing cells using light (activated) sabers – Stephen W.G. Tait. https://rupress.org/jcb/article/221/6/e202205018/213218
BAX and BAK dynamics control mitochondrial DNA release during apoptosis – Takahiro Yamazaki and Lorenzo Galluzzi. https://www.nature.com/articles/s41418-022-00985-2
Apoptosis and cell death 