Bcl-2 family proteins
Mitochondrial dynamics regulate genome stability via control of caspase-dependent DNA damage – Kai Cao, Joel S. Riley, Rosalie Heilig, Alfredo E. Montes-Gómez, Esmee Vringer, Kevin Berthenet, Catherine Cloix, Yassmin Elmasry, David G. Spiller, Gabriel Ichim, Kirsteen J. Campbell, Andrew P. Gilmore, Stephen W.G. Tait. https://www.cell.com/developmental-cell/fulltext/S1534-5807(22)00229-5
Disruption of mitochondrial quality control genes promotes caspase-resistant cell survival following apoptotic stimuli – Yulia Kushnareva, Vivian Moraes, Julian Suess, Bjoern Peters, Donald D. Newmeyer, Tomomi Kuwana. https://www.jbc.org/article/S0021-9258(22)00275-7/fulltext
Bcl-xL enforces a slow-cycling state necessary for survival in the nutrient-deprived microenvironment of pancreatic cancer – Yogev Sela, Jinyang Li, Shivahamy Maheswaran, Robert J Norgard, Salina Yuan, Maimon E Hubbi, Miriam Doepner, Jimmy P Xu, Elaine S Ho, Clementina Mesaros, Colin Sheehan, Grace Croley, Alexander Muir, Ian A Blair, Ophir Shalem, Chi V Dang, Ben Z Stanger. https://aacrjournals.org/cancerres/article-abstract/doi/10.1158/0008-5472.CAN-22-0431/682341
Acetic acid triggers cytochrome c release in yeast heterologously expressing human Bax – Joana P. Guedes, Vitória Baptista, Cátia Santos-Pereira, Maria João Sousa, Stéphen Manon, Susana R. Chaves, Manuela Côrte-Real. https://link.springer.com/article/10.1007/s10495-022-01717-0
Increased apoptotic sensitivity of glioblastoma enables therapeutic targeting by BH3-mimetics – Anna L. Koessinger, Catherine Cloix, Dominik Koessinger, Dieter Henrik Heiland, Florian J. Bock, Karen Strathdee, Kevin Kinch, Laura Martínez-Escardó, Nikki R. Paul, Colin Nixon, Gaurav Malviya, Mark R. Jackson, Kirsteen J. Campbell, Katrina Stevenson, Sandeep Davis, Yassmin Elmasry, Asma Ahmed, Jim O’Prey, Gabriel Ichim, Oliver Schnell, William Stewart, Karen Blyth, Kevin M. Ryan, Anthony J. Chalmers, Jim C. Norman and Stephen W. G. Tait. https://www.nature.com/articles/s41418-022-01001-3
Death receptors
Tankyrase-mediated ADP-ribosylation is a regulator of TNF-induced death – Lin Liu, Jarrod J. Sandow, Deena M. Leslie Pedrioli, Andre L. Samson, Natasha Silke, Tobias Kratina, Rebecca L. Ambrose, Marcel Doerflinger, Zhaoqing Hu, Emma Morrish, Diep Chau, Andrew J. Kueh, Cheree Fitzibbon, Marc Pellegrini, Jaclyn S. Pearson, Michael O. Hottiger, Andrew I. Webb, Najoua Lalaoui, John Silke. https://www.science.org/doi/full/10.1126/sciadv.abh2332
Human B Cells Mediate Innate Anti-Cancer Cytotoxicity Through Concurrent Engagement of Multiple TNF Superfamily Ligands – Bratislav M Janjic, Aditi Kulkarni, Robert L Ferris, Lazar Vujanovic, Nikola L Vujanovic. https://www.frontiersin.org/articles/10.3389/fimmu.2022.837842/full
FasL microgels induce immune acceptance of islet allografts in nonhuman primates – Ji Lei, María M. Coronel, Esma S. Yolcu, Hongping Deng, Orlando Grimany-Nuno, Michael D. Hunckler, Vahap Ulker, Zhihong Yang, Kang M. Lee, Alexander Zhang, Hao Luo, Cole W. Peters, Zhongliang Zou, Tao Chen, Zhenjuan Wang, Colleen S. McCoy, Ivy A. Rosales, James F. Markmann, Haval Shirwan, Andrés J. García. https://www.science.org/doi/full/10.1126/sciadv.abm9881
Caspases and IAPs
Pathogen hijacks programmed cell death signaling by arginine ADPR-deacylization of caspases – Ting Peng, Xinyuan Tao, Zhujun Xia, Shufan Hu, Juan Xue, Qiuyu Zhu, Xing Pan, Qiang Zhang, Shan Li. https://www.cell.com/molecular-cell/fulltext/S1097-2765(22)00219-2
Caspase cleavage and nuclear retention of the energy sensor AMPK-α1 during apoptosis – Anees Rahman Cheratta, Faisal Thayyullathil, Simon A. Hawley, Fiona A. Ross, Abdelmajdid Atrih, Douglas J. Lamont, Siraj Pallichankandy, Karthikeyan Subburayan, Ameer Alakkal, Rachid Rezgui, Alex Gray, D. Grahame Hardie, Sehamuddin Galadari. https://www.cell.com/cell-reports/fulltext/S2211-1247(22)00525-3
Caspase-9b drives cellular transformation, lung inflammation, and lung tumorigenesis – Minjung Kim, Ngoc T Vu, Xue Wang, Gamze B Bulut, Min-Hsuan Wang, Cora Uram-Tuculescu, Raghavendra Pillappa, Sungjune Kim, Charles E Chalfant.. https://aacrjournals.org/mcr/article/doi/10.1158/1541-7786.MCR-21-0905/696288/
XIAP promotes melanoma growth by inducing tumour neutrophil infiltration – Mila Daoud, Pia Nora Broxtermann, Fabian Schorn, J Paul Werthenbach, Jens Michael Seeger, Lars M Schiffmann, Kerstin Brinkmann, Domagoj Vucic, Thomas Tüting, Cornelia Mauch, Dagmar Kulms, Paola Zigrino, Hamid Kashkar. https://www.embopress.org/doi/full/10.15252/embr.202153608
Necroptosis
Osmotic stress activates RIPK3/MLKL-mediated necroptosis by increasing cytosolic pH through a plasma membrane Na+/H+ exchanger – Wenbin Zhang, Weiliang Fan, Jia Guo, Xiaodong Wang. https://www.science.org/doi/abs/10.1126/scisignal.abn5881
Z-DNA binding protein 1 promotes heatstroke-induced cell death – Fangfang Yuan, Jizhen Cai, Jianfeng Wu, Yiting Tang, Kai Zhao, Fang Liang, Fanglin Li, Xinyu Yang, Zhihui He, Timothy R. Billiar, Haichao Wang, Lei Su, Ben Lu. https://www.science.org/doi/abs/10.1126/science.abg5251
ADAR1 masks the cancer immunotherapeutic promise of ZBP1-driven necroptosis – Ting Zhang, Chaoran Yin, Aleksandr Fedorov, Liangjun Qiao, Hongliang Bao, Nazar Beknazarov, Shiyu Wang, Avishekh Gautam, Riley M. Williams, Jeremy Chase Crawford, Suraj Peri, Vasily Studitsky, Amer A. Beg, Paul G. Thomas, Carl Walkley, Yan Xu, Maria Poptsova, Alan Herbert and Siddharth Balachandran. https://www.nature.com/articles/s41586-022-04753-7
Pyroptosis
GSDMEa-mediated pyroptosis is bi-directionally regulated by caspase and required for effective bacterial clearance in teleost – Hang Xu, Shuai Jiang, Chao Yu, Zihao Yuan and Li Sun. https://www.nature.com/articles/s41419-022-04896-5
Efferocytosis, entosis etc
Targeting SLC7A11 improves efferocytosis by dendritic cells and wound healing in diabetes – Sophia Maschalidi, Parul Mehrotra, Burcu N. Keçeli, Hannah K. L. De Cleene, Kim Lecomte, Renée Van der Cruyssen, Pauline Janssen, Jonathan Pinney, Geert van Loo, Dirk Elewaut, Ann Massie, Esther Hoste and Kodi S. Ravichandran. https://www.nature.com/articles/s41586-022-04754-6
Cooperative epithelial phagocytosis enables error correction in the early embryo – Esteban Hoijman, Hanna-Maria Häkkinen, Queralt Tolosa-Ramon, Senda Jiménez-Delgado, Chris Wyatt, Marta Miret-Cuesta, Manuel Irimia, Andrew Callan-Jones, Stefan Wieser and Verena Ruprecht. https://www.nature.com/articles/s41586-021-03200-3
Neuronal apoptosis drives remodeling states of microglia and shifts in survival pathway dependence -Sarah Rose Anderson, Jacqueline M Roberts, Nathaniel Ghena, Emmalyn A Irvin, Joon Schwakopf, Isabelle B Cooperstein, Alejandra Bosco, Monica L Vetter. https://elifesciences.org/articles/76564
Toll-9 interacts with Toll-1 to mediate a feedback loop during apoptosis-induced proliferation in Drosophila – Alicia Shields, Alla Amcheslavsky, Elizabeth Brown, Tom V. Lee, Yingchao Nie, Takahiro Tanji, Y. Tony Ip, Andreas Bergmann. https://www.cell.com/cell-reports/fulltext/S2211-1247(22)00588-5
Extracellular ATP facilitates cell extrusion from epithelial layers mediated by cell competition or apoptosis – Yusuke Mori, Naoka Shiratsuchi, Nanami Sato, Azusa Chaya, Nobuyuki Tanimura, Susumu Ishikawa, Mugihiko Kato, Ikumi Kameda, Shunsuke Kon, Yukinari Haraoka, Tohru Ishitani, Yasuyuki Fujita. https://www.cell.com/current-biology/fulltext/S0960-9822(22)00491-2
Miscellanous
Erebosis, a new cell death mechanism during homeostatic turnover of gut enterocytes – Hanna M. Ciesielski, Hiroshi Nishida, Tomomi Takano, Aya Fukuhara, Tetsuhisa Otani, Yuko Ikegawa, Morihiro Okada, Takashi Nishimura, Mikio Furuse, Sa Kan Yoo. https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3001586
Robust transcriptional indicators of immune cell death revealed by spatio-temporal transcriptome analyses – Jose Salguero-Linares, Irene Serrano, Nerea Ruiz-Solani, Marta Salas-Gómez, Ujjal Jyoti Phukan, Victor Manuel González, Martí Bernardo-Faura, Marc Valls, David Rengel, Nuria S. Coll. https://www.cell.com/molecular-plant/fulltext/S1674-2052(22)00147-2
Fatty acid oxidation protects cancer cells from apoptosis by increasing mitochondrial membrane lipids – Yi-Jia Li, Johannes Francois Fahrmann, Maryam Aftabizadeh, Qianqian Zhao, Satyendra C. Tripathi, Chunyan Zhang, Yuan Yuan, David Ann, Samir Hanash, Hua Yu. https://www.cell.com/cell-reports/fulltext/S2211-1247(22)00645-3
PI(18:1/18:1) is a SCD1-derived lipokine that limits stress signaling – Maria Thürmer, André Gollowitzer, Helmut Pein, Konstantin Neukirch, Elif Gelmez, Lorenz Waltl, Natalie Wielsch, René Winkler, Konstantin Löser, Julia Grander, Madlen Hotze, Sönke Harder, Annika Döding, Martina Meßner, Fabiana Troisi, Maximilian Ardelt, Hartmut Schlüter, Johanna Pachmayr, Óscar Gutiérrez-Gutiérrez, Karl Lenhard Rudolph, Kathrin Thedieck, Ulrike Schulze-Späte, Cristina González-Estévez, Christian Kosan, Aleš Svatoš, Marcel Kwiatkowski and Andreas Koeberle. https://www.nature.com/articles/s41467-022-30374-9
Flow cytometric single cell-based assay to simultaneously detect cell death, cell cycling, DNA content and cell senescence – Elizabeth Lieschke, Zilu Wang, Catherine Chang, Clare E. Weeden, Gemma L. Kelly and Andreas Strasser. https://www.nature.com/articles/s41418-022-00964-7
Reviews
Adapted to Survive: Targeting Cancer Cells with BH3 Mimetics – Joan Montero and Rizwan Haq. https://aacrjournals.org/cancerdiscovery/article/12/5/1217/694529
Protein–protein and protein–lipid interactions of pore-forming BCL-2 family proteins in apoptosis initiation – Giridhar Sekar, Adedolapo Ojoawo, Tudor Moldoveanu. https://portlandpress.com/biochemsoctrans/article-abstract/doi/10.1042/BST20220323/231272
Immunogenic cell stress and injury versus immunogenic cell death: implications for improving cancer treatment with immune checkpoint blockade – Ganapathy Sriram, Tiffany R Emmons, Lauren E Milling, Darrell J Irvine, Michael B Yaffe. https://www.tandfonline.com/doi/full/10.1080/23723556.2022.2039038
Targeting the apoptosis pathway to treat tumours of the paediatric nervous system – Marie-Claire Fitzgerald, Philip J. O’Halloran, Niamh M. C. Connolly and Brona M. Murphy. https://www.nature.com/articles/s41419-022-04900-y
Of the many cellular responses activated by TP53, which ones are critical for tumour suppression? – Annabella F. Thomas, Gemma L. Kelly and Andreas Strasser. https://www.nature.com/articles/s41418-022-00996-z
No longer married to inflammasome signaling: the diverse interacting pathways leading to pyroptotic cell death – Ashley Weir, James E. Vince. https://portlandpress.com/biochemj/article/479/10/1083/231341
Deubiquitinases in cell death and inflammation – Kim Newton, Alexander D. Gitlin. https://portlandpress.com/biochemj/article/479/10/1103/231340
RIP1 post-translational modifications – Eugene Varfolomeev, Domagoj Vucic. https://portlandpress.com/biochemj/article-abstract/479/9/929/231273
Comments
[AMPK] Cleaved to keep dying cells alive – Leslie K. Ferrarelli. https://www.science.org/doi/full/10.1126/scisignal.abq8516
A novel crosstalk between autophagosomes and phagosomes that facilitates the clearance of apoptotic cells – Zheng Zhou and Omar Peña-Ramos. https://www.tandfonline.com/doi/abs/10.1080/15548627.2022.2080384
Cuproptosis: Cellular and molecular mechanisms underlying copper-induced cell death – Paul A. Cobine, Donita C. Brady. https://www.cell.com/molecular-cell/fulltext/S1097-2765(22)00435-X
IFNγ regulates ferroptosis with fatty acids – Zhe Wang. https://www.nature.com/articles/s41556-022-00921-z
ATP and ROS signal cell extrusion – Paulina Strzyz. https://www.nature.com/articles/s41580-022-00487-6
European Workshop on Cell Death in Fiuggi (near Roma) June 22: registration and poster submission still open if you can pay registration before June 10th. See you there!
ECDO 2022 in Bonn, september. https://www.ecdo.eu/
Apoptosis and cell death 