ApoList – July/August 2022


Bcl-2 family proteins


The BCL‐2 family member BID plays a role during embryonic development in addition to its BH3‐only protein function by acting in parallel to BAX, BAK and BOK – Francine S Ke, Steven Holloway, Rachel T Uren, Agnes W Wong, Melissa H Little, Ruth M Kluck, Anne K Voss, Andreas Strasser. https://www.embopress.org/doi/abs/10.15252/embj.2021110300

Ca2+-mediated mitochondrial inner membrane permeabilization induces cell death independently of Bax and Bak – Giovanni Quarato, Fabien Llambi, Cliff S. Guy, Jaeki Min, Marisa Actis, Huan Sun, Shilpa Narina, Shondra M. Pruett-Miller, Junmin Peng, Zoran Rankovic and Douglas R. Green. https://www.nature.com/articles/s41418-022-01025-9

BH3 mimetic drugs cooperate with Temozolomide, JQ1 and inducers of ferroptosis in killing glioblastoma multiforme cells – Diane Moujalled, Adam G. Southon, Eiman Saleh, Kerstin Brinkmann, Francine Ke, Melinda Iliopoulos, Ryan S. Cross, Misty R. Jenkins, Duong Nhu, Zilu Wang, Melissa X. Shi, Ruth M. Kluck, Guillaume Lessene, Stephanie Grabow, Ashley I. Bush and Andreas Strasser. https://www.nature.com/articles/s41418-022-00977-2

BCL-2 isoform β promotes angiogenesis by TRiC-mediated upregulation of VEGF-A in lymphoma – Xiaohang Hang, Lei Zhao, Baohong Wu, Shujun Li, Pengpeng Liu, Jing Xu, Xinyuan Wang, Pengliang Chi, Chong Chen, Ting Niu, Lunzhi Dai and Yu Liu. https://www.nature.com/articles/s41388-022-02372-0

Ceramide-induced integrated stress response overcomes Bcl-2 inhibitor resistance in acute myeloid leukemia – Alexander C. Lewis, Victoria S. Pope, Melinda N. Tea, Manjun Li, Gus O. Nwosu, Thao M. Nguyen, Craig T. Wallington-Beddoe, Paul A. B. Moretti, Dovile Anderson, Darren J. Creek, Maurizio Costabile, Saira R. Ali, Chloe A. L. Thompson-Peach, B. Kate Dredge, Andrew G. Bert, Gregory J. Goodall, Paul G. Ekert, Anna L. Brown, Richard D’Andrea, Nirmal Robinson, Melissa R. Pitman, Daniel Thomas, David M. Ross, Briony L. Gliddon, Jason A. Powell, Stuart M. Pitson. https://ashpublications.org/blood/article/139/26/3737/485003

Structural and biochemical analyses of Bcl-xL in complex with the BH3 domain of peroxisomal testis-specific 1 – Lim D, Jin S, Shin HC, Kim W, Choi JS, Oh DB, Kim SJ, Seo J, Ku B. https://www.sciencedirect.com/science/article/pii/S0006291X22011147?via%3Dihub

A common deletion at BAK1 reduces enhancer activity and confers risk of intracranial germ cell tumors – Kyuto Sonehara, Yui Kimura, Yoshiko Nakano, Tatsuya Ozawa, Meiko Takahashi, Ken Suzuki, Takashi Fujii, Yuko Matsushita, Arata Tomiyama, Toshihiro Kishikawa, Kenichi Yamamoto, Tatsuhiko Naito, Tomonari Suzuki, Shigeru Yamaguchi, Tomoru Miwa, Hikaru Sasaki, Masashi Kitagawa, Naoyuki Ohe, Junya Fukai, Hideki Ogiwara, Atsufumi Kawamura, Satoru Miyawaki, Fumihiko Matsuda, Nobutaka Kiyokawa, Koichi Ichimura, Ryo Nishikawa, Yukinori Okada and Keita Terashima. https://www.nature.com/articles/s41467-022-32005-9


“Death” receptors


TRAIL protects the immature lung from hyperoxic injury – Tayyab Shahzad, Cho-Ming Chao, Stefan Hadzic, Judith Behnke, Luisa Biebach, Eva Böttcher-Friebertshäuser, Jochen Wilhelm, Anne Hilgendorff, Klaus-Peter Zimmer, Rory E. Morty, Saverio Bellusci and Harald Ehrhardt. https://www.nature.com/articles/s41419-022-05072-5

Engagement of TRAIL triggers degranulation and IFNγ production in human natural killer cells – Johannes Höfle, Timo Trenkner, Nadja Kleist, Vera Schwane, Sarah Vollmers, Bryan Barcelona, Annika Niehrs, Pia Fittje, Van Hung Huynh-Tran, Jürgen Sauter, Alexander H Schmidt, Sven Peine, Angelique Hoelzemer, Laura Richert, Marcus Altfeld, Christian Körner. https://www.embopress.org/doi/full/10.15252/embr.202154133

Indomethacin-induced oxidative stress enhances death receptor 5 signaling and sensitizes tumor cells to adoptive T-cell therapy – Nada S Aboelella, Caitlin Brandle, Ogacheko Okoko et al.. https://jitc.bmj.com/content/10/7/e004938

Engineered sTRAIL-armed MSCs overcome STING deficiency to enhance the therapeutic efficacy of radiotherapy for immune checkpoint blockade – Kevin Chih-Yang Huang, Shu-Fen Chiang, Hsin-Yu Chang, William Tzu-Liang Chen, Pei-Chen Yang, Tsung-Wei Chen, Ji-An Liang, An‑Cheng Shiau, Tao-Wei Ke and K. S. Clifford Chao. https://www.nature.com/articles/s41419-022-05069-0

Early B cell factor 4 modulates FAS-mediated apoptosis and promotes cytotoxic function in human immune cells – Satoshi Kubo, Rhea Kataria, Yikun Yao, Justin Q. Gabrielski, Lixin Zheng, Tovah E. Markowitz, Waipan Chan, Jian Song, Arun K. Boddapati, Keita Saeki, Björn Häupl, Ann Y. Park, Yan H. Cheng, Jing Cui, Thomas Oellerich and Michael J. Lenardo. https://www.pnas.org/doi/10.1073/pnas.2208522119

TAK1 Limits Death Receptor Fas-Induced Proinflammatory Cell Death in Macrophages – Kengo Maeda, Jun Nakayama, Shinsuke Taki and Hideki Sanjo. https://www.jimmunol.org/content/early/2022/08/10/jimmunol.2200322


Caspases


Apoptotic caspases suppress an MDA5-driven IFN response during productive replication of human papillomavirus type 31 – Ning Huang, Des’ree Groover, Blossom Damania and Cary Moody. https://www.pnas.org/doi/10.1073/pnas.2200206119

Apoptotic caspase inhibits innate immune signaling by cleaving NF-κBs in both Mammals and Flies – Di Wu, Zhaowei Wang, Jing Zhang, Adam G. Robinson, Bao Lyu, Ziyu Chen, Chong Wang, Bin Wei, Xiaojun Xia, Qing Zhang and Xi Zhou. https://www.nature.com/articles/s41419-022-05156-2

Caspase-8 auto-cleavage regulates programmed cell death and collaborates with RIPK3/MLKL to prevent lymphopenia – Xiaoming Li, Fang Li, Xixi Zhang, Haiwei Zhang, Qun Zhao, Ming Li, Xiaoxia Wu, Lingxia Wang, Jianling Liu, Xuanhui Wu, Yangjing Ou, Mingyan Xing, Yue Zhang, Jiangshan Deng, Xiuzhe Wang, Yan Luo, Jinbao Li, Yuwu Zhao and Haibing Zhang. https://www.nature.com/articles/s41418-022-00938-9

PKR and TLR3 trigger distinct signals that coordinate the induction of antiviral apoptosis – Wenjie Zuo, Mai Wakimoto, Noriyasu Kozaiwa, Yutaro Shirasaka, Seong-Wook Oh, Shiori Fujiwara, Hitoshi Miyachi, Amane Kogure, Hiroki Kato and Takashi Fujita. https://www.nature.com/articles/s41419-022-05101-3


Necroptosis


Mitochondrial ROS promotes susceptibility to infection via gasdermin D-mediated necroptosis – Chi G. Weindel, Eduardo L. Martinez, Xiao Zhao, Cory J. Mabry, Samantha L. Bell, Krystal J. Vail, Aja K. Coleman, Jordyn J. VanPortfliet, Baoyu Zhao, Allison R. Wagner, Sikandar Azam, Haley M. Scott, Pingwei Li, A. Phillip West, Jason Karpac, Kristin L. Patrick, Robert O. Watson. https://www.cell.com/cell/fulltext/S0092-8674(22)00790-5

ADAR1 mutation causes ZBP1-dependent immunopathology – Nicholas W. Hubbard, Joshua M. Ames, Megan Maurano, Lan H. Chu, Kim Y. Somfleth, Nandan S. Gokhale, Margo Werner, Jessica M. Snyder, Katrina Lichauco, Ram Savan, Daniel B. Stetson and Andrew Oberst. https://www.nature.com/articles/s41586-022-04896-7

ADAR1 averts fatal type I interferon induction by ZBP1 – Huipeng Jiao, Laurens Wachsmuth, Simone Wolf, Juliane Lohmann, Masahiro Nagata, Göksu Gökberk Kaya, Nikos Oikonomou, Vangelis Kondylis, Manuel Rogg, Martin Diebold, Simon E. Tröder, Branko Zevnik, Marco Prinz, Christoph Schell, George R. Young, George Kassiotis and Manolis Pasparakis. https://www.nature.com/articles/s41586-022-04878-9

Deficiency of PPP6C protects TNF-induced necroptosis through activation of TAK1 – Yonggang Zou, Qi Zheng, Bin Jiang, Yuning Liu, Yanhua Xu, Liang Ma, Zonghao Hu, Ming Wu & Hai Song. https://www.nature.com/articles/s41419-022-05076-1

Acidosis induces RIPK1-dependent death of glioblastoma stem cells via acid-sensing ion channel 1a – Jan Clusmann, Klaus-Daniel Cortés Franco, David Alejandro Corredor Suárez, Istvan Katona, Maria Girbes Minguez, Nina Boersch, Karolos-Philippos Pissas, Jakob Vanek, Yuemin Tian and Stefan Gründer. https://www.nature.com/articles/s41419-022-05139-3


Pyroptosis


PP1A prevents ROS‐induced pyroptosis by inhibiting MAPK/caspase‐3 in mouse adipose tissue – Yizhe Chen, Meng Che, Chaowei Li, Yizhou Li, Tiantian Zhang, Xinjian Li, Chao Sun. https://febs.onlinelibrary.wiley.com/doi/abs/10.1111/febs.16373?campaign=woletoc


Ferroptosis


ACSL4-dependent ferroptosis does not represent a tumor-suppressive mechanism but ACSL4 rather promotes liver cancer progression – Julia Grube, Marius Maximilian Woitok, Antje Mohs, Stephanie Erschfeld, Celina Lynen, Christian Trautwein and Tobias Otto. https://www.nature.com/articles/s41419-022-05137-5

G9a dictates neuronal vulnerability to inflammatory stress via transcriptional control of ferroptosis – Nicola Rothammer, Marcel S. Woo, Simone Bauer, Lars Binkle-Ladisch, Giovanni Di Liberto, Kristof Egervari, Ingrid Wagner, Undine Haferkamp, Ole Pless, Doron Merkler, Jan Broder Engler, Manuel A. Friese. https://www.science.org/doi/full/10.1126/sciadv.abm5500


Efferocytosis, entosis etc


Efferocytosis of SARS-CoV-2-infected dying cells impairs macrophage anti-inflammatory functions and clearance of apoptotic cells – Ana CG Salina, Douglas dos-Santos, Tamara S Rodrigues, Marlon Fortes-Rocha, Edismauro G Freitas-Filho, Daniel L Alzamora-Terrel, Icaro MS Castro, Thais FC Fraga da Silva, Mikhael HF de Lima, Daniele C Nascimento, Camila M Silva, Juliana E Toller-Kawahisa, Amanda Becerra, Samuel Oliveira, Diego B Caetité, Leticia Almeida, Adriene Y Ishimoto, Thais M Lima, Ronaldo B Martins, Flavio Veras, Natália B do Amaral, Marcela C Giannini, Letícia P Bonjorno, Maria IF Lopes, Maira N Benatti, Sabrina S Batah, Rodrigo C Santana, Fernando C Vilar, Maria A Martins, Rodrigo L Assad, Sergio CL de Almeida, Fabiola R de Oliveira, Eurico Arruda Neto, Thiago M Cunha, José C Alves-Filho, Vania LD Bonato, Fernando Q Cunha, Alexandre T Fabro, Helder I Nakaya, Dario S Zamboni, Paulo Louzada-Junior, Rene DR Oliveira, Larissa D Cunha. https://elifesciences.org/articles/74443

Glycosylation defects, offset by PEPCK-M, drive entosis in breast carcinoma cells – Petra Hyroššová, Marc Aragó, Cristina Muñoz-Pinedo, Francesc Viñals, Pablo M. García-Rovés, Carmen Escolano, Andrés Méndez-Lucas and Jose C. Perales. https://www.nature.com/articles/s41419-022-05177-x

Externalized phosphatidylinositides on apoptotic cells are eat-me signals recognized by CD14 – Ok-Hee Kim, Geun-Hyung Kang, June Hur, Jinwook Lee, YunJae Jung, In-Sun Hong, Hookeun Lee, Seung-Yong Seo, Dae Ho Lee, Cheol Soon Lee, In-Kyu Lee, Susan Bonner-Weir, Jongsoon Lee, Young Joo Park, Hyeonjin Kim, Steven E. Shoelson and Byung-Chul Oh. https://www.nature.com/articles/s41418-022-00931-2

Apoptotic brown adipocytes enhance energy expenditure via extracellular inosine – Birte Niemann, Saskia Haufs-Brusberg, Laura Puetz, Martin Feickert, Michelle Y. Jaeckstein, Anne Hoffmann, Jelena Zurkovic, Markus Heine, Eva-Maria Trautmann, Christa E. Müller, Anke Tönjes, Christian Schlein, Azin Jafari, Holger K. Eltzschig, Thorsten Gnad, Matthias Blüher, Natalie Krahmer, Peter Kovacs, Joerg Heeren and Alexander Pfeifer. https://www.nature.com/articles/s41586-022-05041-0


Miscellanous


Interaction of LATS1 with SMAC links the MST2/Hippo pathway with apoptosis in an IAP-dependent manner – Lucía García-Gutiérrez, Emma Fallahi, Nourhan Aboud, Niall Quinn & David Matallanas. https://www.nature.com/articles/s41419-022-05147-3


Reviews


Death domain fold proteins in immune signaling and transcriptional regulation – Yu-San Huoh, Sun Hur. https://febs.onlinelibrary.wiley.com/doi/full/10.1111/febs.15901

Regulation of innate immune responses by cell death‐associated caspases during virus infection – Yujie Fang, Ke Peng. https://febs.onlinelibrary.wiley.com/doi/full/10.1111/febs.16051

Restoring TRAILR2/DR5-Mediated Activation of Apoptosis upon Endoplasmic Reticulum Stress as a Therapeutic Strategy in Cancer – Rocío Mora-Molina, Abelardo López-Rivas.. https://www.mdpi.com/1422-0067/23/16/8987

Emerging roles of ferroptosis in the tumor immune landscape: from danger signals to anti‐tumor immunity – Lei Shi, Yingqi Liu, Menghuan Li, Zhong Luo. https://febs.onlinelibrary.wiley.com/doi/full/10.1111/febs.16034

Ferroptosis turns 10: Emerging mechanisms, physiological functions, and therapeutic applications – Brent R. Stockwell. https://www.cell.com/cell/fulltext/S0092-8674(22)00708-5

XIAP as a multifaceted molecule in Cellular Signaling – Mina Hanifeh, Farangis Ataei. https://link.springer.com/article/10.1007/s10495-022-01734-z

Programmed cell death detection methods: a systematic review and a categorical comparison – Sana Kari, Kumar Subramanian, Ilenia Agata Altomonte, Akshaya Murugesan, Olli Yli-Harja, Meenakshisundaram Kandhavelu. https://link.springer.com/article/10.1007/s10495-022-01735-y


Comments / other


Remembering apoptosis pioneer Andrew Wyllie (1944–2022) – Christine J. Watson, Gerry Melino, Seamus J. Martin. https://febs.onlinelibrary.wiley.com/doi/full/10.1111/febs.16566

Hold your horses! Reining in your fastest pores with caspase-7 – Jeffrey Y. Zhou, Katherine A. Fitzgerald. https://www.cell.com/immunity/fulltext/S1074-7613(22)00348-X

RIPK1 Promotes Intrinsic and Extrinsic Resistance to Immunotherapy. https://aacrjournals.org/cancerdiscovery/article-abstract/12/7/1607/705209

Lab Meeting: Vishva Dixit. https://dneel.substack.com/p/lab-meeting-vishva-dixit?r=1m5xy3&utm_medium=ios

Conference: “Problems in the Powerhouse: Mitochondrial Dysfunction in Cancer”

Oct. 24/25th. Organizers: Payam Gammage, Stephen Tait , Tom MacVicar. Glasgow, UK

https://www.beatson.gla.ac.uk/Beatson-Workshop-October-2022/programme.html

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