ApoList – August 2021


Bcl-2 family proteins


Breast cancer dependence on MCL-1 is due to its canonical anti-apoptotic function – Kirsteen J. Campbell, Susan M. Mason, Matthew L. Winder, Rosalie B. E. Willemsen, Catherine Cloix, Hannah Lawson, Nicholas Rooney, Sandeep Dhayade, Andrew H. Sims, Karen Blyth and Stephen W. G. Tait. https://www.nature.com/articles/s41418-021-00773-4

The conformational stability of pro-apoptotic BAX is dictated by discrete residues of the protein core – Noah B. Bloch, Thomas E. Wales, Michelle S. Prew, Hannah R. Levy, John R. Engen and Loren D. Walensky. https://www.nature.com/articles/s41467-021-25200-7

Hexokinases inhibit death receptor–dependent apoptosis on the mitochondria – Joachim Lauterwasser, Franziska Fimm-Todt, Aline Oelgeklaus, Annabell Schreiner, Kathrin Funk, Hugo Falquez-Medina, Ramona Klesse, Günther Jahreis, Ralf M. Zerbes, Katelyn O’Neill, Martin van der Laan, Xu Luo, and Frank Edlich. https://www.pnas.org/content/118/33/e2021175118.abstract

Tracing the evolutionary history of Ca 2+-signaling modulation by human Bcl-2: Insights from the Capsaspora owczarzaki IP 3 receptor ortholog – Nicolas Rosa, Victoria Shabardina, Hristina Ivanova, Arnau Sebé-Pedrós, David I Yule, Geert Bultynck. https://pubmed.ncbi.nlm.nih.gov/34400171/

Importance of Bcl-2-family proteins in murine hematopoietic progenitor and early B cells – Constanze Kurschat, Arlena Metz, Susanne Kirschnek and Georg Häcker. https://www.nature.com/articles/s41419-021-04079-8


BH3 mimetics


Long-term Follow-up of Patients with Relapsed or Refractory Non–Hodgkin Lymphoma Treated with Venetoclax in a Phase I, First-in-Human Study – Matthew S. Davids, Andrew W. Roberts, Vaishalee P. Kenkre, William G. Wierda, Abhijeet Kumar, Thomas J. Kipps, Michelle Boyer, Ahmed Hamed Salem, John C. Pesko, Jennifer A. Arzt, Margaret Mantas, Su Y. Kim and John F. Seymour. https://clincancerres.aacrjournals.org/content/27/17/4690

Therapeutic Synergy in Esophageal Cancer and Mesothelioma Is Predicted by Dynamic BH3 Profiling – Deborah R. Surman, Yuan Xu, Min-Jung Lee, Jane Trepel, Kate Brown, Maheshwari Ramineni, Taylor G. Splawn, Laurence P. Diggs, H. Courtney Hodges, Jeremy L. Davis, Hyun-Sung Lee, Bryan M. Burt and Robert Taylor Ripley. https://mct.aacrjournals.org/content/20/8/1469.long

Pharmacologic Targeting of Mcl-1 Induces Mitochondrial Dysfunction and Apoptosis in B-Cell Lymphoma Cells in a TP53- and BAX-Dependent Manner – Tingting Liu, Vi Lam, Elana Thieme, Duanchen Sun, Xiaoguang Wang, Fei Xu, Lili Wang, Olga V. Danilova, Zheng Xia, Jeffrey W. Tyner, Stephen E. Kurtz and Alexey V. Danilov. https://clincancerres.aacrjournals.org/content/27/17/4910

Constitutive BAK/MCL1 complexes predict paclitaxel and S63845 sensitivity of ovarian cancer – Dongyan Liu, Xiaonan Hou, Wangyu Wu, Valentina Zafagnin, Yunjian Li, Cristina Correia, Zhiyang Zhao, Chenggang Zhao, Zhirong Liu, Tao Zhang, Zhiyou Fang, Hongzhi Wang, Chao Xu, Saravut J. Weroha, Scott H. Kaufmann and Haiming Dai. https://www.nature.com/articles/s41419-021-04073-0


Death receptors and caspases


Caspase-8 mutations associated with head and neck cancer differentially retain functional properties related to TRAIL-induced apoptosis and cytokine induction – Zhibin Cui, Hadas Dabas, Brandon C. Leonard, Jamie V. Shiah, Jennifer R. Grandis and Daniel E. Johnson. https://www.nature.com/articles/s41419-021-04066-z

Hexokinases inhibit death receptor–dependent apoptosis on the mitochondria – Joachim Lauterwasser, Franziska Fimm-Todt, Aline Oelgeklaus, Annabell Schreiner, Kathrin Funk, Hugo Falquez-Medina, Ramona Klesse, Günther Jahreis, Ralf M. Zerbes, Katelyn O’Neill, Martin van der Laan, Xu Luo, and Frank Edlich. https://www.pnas.org/content/118/33/e2021175118.abstract

A unique death pathway keeps RIPK1 D325A mutant mice in check at embryonic day 10.5 – Yingying Zhang, Kai Huang, Yuxia Zhang, Tao Han, Lang Li, Chenchen Ruan, Ye-hsuan Sun, Wenke Shi, Wei Han, Su-qin Wu, Jing Song, Jun Liu, Jiahuai Han. https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3001304

Effects of intravitreal injection of siRNA against caspase-2 on retinal and optic nerve degeneration in air blast induced ocular trauma – Chloe N. Thomas, Alexandra Bernardo-Colón, Ella Courtie, Gareth Essex, Tonia S. Rex, Richard J. Blanch and Zubair Ahmed. https://www.nature.com/articles/s41598-021-96107-y


Ferroptosis


Peroxidation of n-3 and n-6 polyunsaturated fatty acids in the acidic tumor environment leads to ferroptosis-mediated anticancer effects – Emeline Dierge, Elena Debock, Céline Guilbaud, Cyril Corbet, Eric Mignolet, Louise Mignard, Estelle Bastien, Chantal Dessy, Yvan Larondelle, Olivier Feron. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(21)00233-3


Miscellanous


Macrophage and neutrophil death programs differentially confer resistance to tuberculosis – Michael Dominic Stutz, Cody Charles Allison, Samar Ojaimi, Simon Peter Preston, Marcel Doerflinger, Philip Arandjelovic, Lachlan Whitehead, Stefanie M. Bader, Daniel Batey, Marie-Liesse Asselin-Labat, Marco J. Herold, Andreas Strasser, Nicholas P. West, Marc Pellegrini. https://www.cell.com/immunity/fulltext/S1074-7613(21)00253-3

Cytotoxic T cells are able to efficiently eliminate cancer cells by additive cytotoxicity – Bettina Weigelin, Annemieke Th. den Boer, Esther Wagena, Kelly Broen, Harry Dolstra, Rob J. de Boer, Carl G. Figdor, Johannes Textor and Peter Friedl. https://www.nature.com/articles/s41467-021-25282-3


Reviews


Apoptosis – Fueling the oncogenic fire – Camila Castillo Ferrer, Kevin Berthenet, Gabriel Ichim. https://febs.onlinelibrary.wiley.com/doi/10.1111/febs.15624

Ferroptosis in the tumor microenvironment: perspectives for immunotherapy – Huanji Xu, Di Ye, Meiling Ren, Hongying Zhang, Feng Bi. https://www.cell.com/trends/molecular-medicine/fulltext/S1471-4914(21)00181-7

Caspase-2 as a master regulator of genomic stability – Gelina S. Kopeina, Boris Zhivotovsky. https://www.cell.com/trends/cell-biology/fulltext/S0962-8924(21)00048-9

Interactions of multidomain pro-apoptotic and anti-apoptotic proteins in cancer cell death – Alexander Chota, Blassan P. George, and Heidi Abrahamse. https://www.oncotarget.com/article/28031/text/


Comments


Mitochondria control pyroptosis – Nicholas J. Bernard. https://www.nature.com/articles/s41590-021-01017-w

TNF-dependent hyperactivation of RIPK1-dependent cytotoxic signaling during embryogenesis and inflammation – Edward S. Mocarski, Pratyusha Mandal. https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3001371

Ending on a sour note: Lipids orchestrate ferroptosis in cancer – Mike Lange, James A. Olzmann. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(21)00327-2

Editor Profile: Brent Derry. https://febs.onlinelibrary.wiley.com/doi/full/10.1111/febs.15893

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