ApoList – July 2021


Apoptosis and tissue homeostasis


Microenvironmental innate immune signaling and cell mechanical responses promote tumor growth – Jun Zhou, Erica Valentini, Michael Boutros. https://www.cell.com/developmental-cell/fulltext/S1534-5807(21)00485-8

Apoptotic cells represent a dynamic stem cell niche governing proliferation and tissue regeneration – Roi Ankawa, Nitzan Goldberger, Yahav Yosefzon, Elle Koren, Marianna Yusupova, Daniel Rosner, Alona Feldman, Shulamit Baror-Sebban, Yosef Buganim, David J. Simon, Marc Tessier-Lavigne, Yaron Fuchs. https://www.cell.com/developmental-cell/fulltext/S1534-5807(21)00486-X

Homeostatic apoptosis prevents competition-induced atrophy in follicular B cells – Stéphane Chappaz, Kate McArthur, Liam Kealy, Charity W. Law, Maximilien Tailler, Rachael M. Lane, Anna Lieschke, Matthew E. Ritchie, Kim L. Good-Jacobson, Andreas Strasser, Benjamin T. Kile. https://www.cell.com/cell-reports/fulltext/S2211-1247(21)00847-0


Bcl-2 family proteins


BCL-XL is crucial for progression through the adenoma-to-carcinoma sequence of colorectal cancer – Ramesh P, Lannagan TRM, Jackstadt R, Atencia Taboada L, Lansu N, Wirapati P, van Hooff SR, Dekker D, Pritchard J, Kirov AB, van Neerven SM, Tejpar S, Kops GJPL, Sansom OJ, Medema JP. https://www.nature.com/articles/s41418-021-00816-w

ER+ Breast Cancer Strongly Depends on MCL-1 and BCL-xL Anti-Apoptotic Proteins – Clara Alcon, Jorge Gómez Tejeda Zañudo, Reka Albert, Nikhil Wagle, Maurizio Scaltriti, Anthony Letai, Josep Samitier and Joan Montero. https://www.mdpi.com/2073-4409/10/7/1659

Virus-mediated inactivation of anti-apoptotic Bcl-2 family members promotes Gasdermin-E-dependent pyroptosis in barrier epithelial cells – Megan H. Orzalli, Aleksandra Prochera, Laurellee Payne, Avi Smith, Jonathan A. Garlick, Jonathan C. Kagan. https://www.cell.com/immunity/fulltext/S1074-7613(21)00174-6

An amphipathic Bax core dimer forms part of the apoptotic pore wall in the mitochondrial membrane – Fujiao Lv, Fei Qi, Zhi Zhang, Maorong Wen, Justin Kale, Alessandro Piai, Lingyu Du, Shuqing Wang, Liujuan Zhou, Yaqing Yang, Bin Wu, Zhijun Liu, Juan del Rosario, Justin Pogmore, James J Chou, David W Andrews, Jialing Lin, Bo OuYang. https://www.embopress.org/doi/full/10.15252/embj.2020106438

Guanylate-binding proteins induce apoptosis of leukemia cells by regulating MCL-1 and BAK – Yongyang Luo, Hanyong Jin, Je Hyeong Kim and Jeehyeon Bae. https://www.nature.com/articles/s41389-021-00341-y

Dynamic BH3 profiling identifies active BH3 mimetic combinations in non-small cell lung cancer – Danielle S. Potter, Ruochen Du, Patrick Bhola, Raphael Bueno and Anthony Letai. https://www.nature.com/articles/s41419-021-04029-4

Bcl-2/Bcl-xL inhibitor ABT-263 overcomes hypoxia-driven radioresistence and improves radiotherapy – Violetta Ritter, Franziska Krautter, Diana Klein, Verena Jendrossek and Justine Rudner. https://www.nature.com/articles/s41419-021-03971-7

Cell line-specific network models of ER+ breast cancer identify potential PI3Kα inhibitor resistance mechanisms and drug combinations – Jorge Gómez Tejeda Zañudo, Pingping Mao, Clara Alcon, Kailey Kowalski, Gabriela N Johnson, Guotai Xu, Jose Baselga, Maurizio Scaltriti, Anthony Letai, Joan Montero, Réka Albert and Nikhil Wagle. https://cancerres.aacrjournals.org/content/early/2021/07/12/0008-5472.CAN-21-1208


Death receptors


First-in-human DR5 PET reveals insufficient DR5 expression in patients with gastrointestinal cancer – Shujing Wang, Hua Zhu, Yingjie Li et al. https://jitc.bmj.com/content/9/7/e002926

TRAIL-receptor 2—a novel negative regulator of p53 – Anna Willms, Hella Schupp, Michelle Poelker, Alshaimaa Adawy, Jan Frederik Debus, Torsten Hartwig, Tim Krichel, Jürgen Fritsch, Steven Singh, Henning Walczak, Silvia von Karstedt, Heiner Schäfer and Anna Trauzold. https://www.nature.com/articles/s41419-021-04048-1

Reconstruction of the Fas-Based Death-Inducing Signaling Complex (DISC) Using a Protein–Protein Docking Meta-Approach – Sayyed Jalil Mahdizadeh, Melissa Thomas, and Leif A. Eriksson. https://pubs.acs.org/doi/10.1021/acs.jcim.1c00301

Antioxidant and food additive BHA prevents TNF cytotoxicity by acting as a direct RIPK1 inhibitor – Tom Delanghe, Jon Huyghe, Seungheon Lee, Dario Priem, Samya Van Coillie, Barbara Gilbert, Sze Men Choi, Peter Vandenabeele, Alexei Degterev, Gregory D. Cuny, Yves Dondelinger and Mathieu J. M. Bertrand. https://www.nature.com/articles/s41419-021-03994-0

PLEKHO2 inhibits TNFα-induced cell death by suppressing RIPK1 activation – Chenchen Zhou, Xueli Zhang, Cuiping Yang, Yuan He and Luo Zhang. https://www.nature.com/articles/s41419-021-04001-2


Caspases and c-FLIP


Characterization of caspase-7 interaction with RNA – Alexandre Desroches, Jean-Bernard Denault. https://portlandpress.com/biochemj/article-abstract/478/13/2681/229082

c-FLIP regulates autophagy by interacting with Beclin-1 and influencing its stability – Luana Tomaipitinca, Simonetta Petrungaro, Pasquale D’Acunzo, Angelo Facchiano, Amit Dubey, Salvatore Rizza, Federico Giulitti, Eugenio Gaudio, Antonio Filippini, Elio Ziparo, Francesco Cecconi and Claudia Giampietri. https://www.nature.com/articles/s41419-021-03957-5

Puma- and Caspase9-mediated apoptosis is dispensable for p53-driven neural crest-based developmental defects – Margot E. Bowen, Abigail S. Mulligan, Aryo Sorayya and Laura D. Attardi. https://www.nature.com/articles/s41418-021-00738-7


Necroptosis


A toolbox for imaging RIPK1, RIPK3, and MLKL in mouse and human cells – André L. Samson, Cheree Fitzgibbon, Komal M. Patel, Joanne M. Hildebrand, Lachlan W. Whitehead, Joel S. Rimes, Annette V. Jacobsen, Christopher R. Horne, Xavier J. Gavin, Samuel N. Young, Kelly L. Rogers, Edwin D. Hawkins and James M. Murphy. https://www.nature.com/articles/s41418-021-00742-x

E-type prostanoid receptor 4 drives resolution of intestinal inflammation by blocking epithelial necroptosis – Jay V. Patankar, Tanja M. Müller, Srinivas Kantham, Miguel Gonzalez Acera, Fabrizio Mascia, Kristina Scheibe, Mousumi Mahapatro, Christina Heichler, Yuqiang Yu, Wei Li, Barbara Ruder, Claudia Günther, Moritz Leppkes, Mano J. Mathew, Stefan Wirtz, Clemens Neufert, Anja A. Kühl, Jay Paquette, Kevan Jacobson, Raja Atreya, Sebastian Zundler, Markus F. Neurath, Robert N. Young and Christoph Becker. https://www.nature.com/articles/s41556-021-00708-8

CAMK2/CaMKII activates MLKL in short-term starvation to facilitate autophagic flux – Qionghui Zhan, Jaepyo Jeon, Ying Li, Yu Huang, Jian Xiong, Qiaochu Wang, Tian-Le Xu, Yong Li, Fu-Hai Ji, Guangwei Du and Michael X Zhu. https://www.tandfonline.com/doi/full/10.1080/15548627.2021.1954348

OTUB1 prevents lethal hepatocyte necroptosis through stabilization of c-IAP1 during murine liver inflammation – Josephin Koschel, Gopala Nishanth, Sissy Just, Kunjan Harit, Andrea Kröger, Martina Deckert, Michael Naumann & Dirk Schlüter. https://www.nature.com/articles/s41418-021-00752-9


Ferroptosis


Dysfunction of the key ferroptosis-surveilling systems hypersensitizes mice to tubular necrosis during acute kidney injury – Wulf Tonnus, Claudia Meyer, Christian Steinebach, Alexia Belavgeni, Anne von Mässenhausen, Nadia Zamora Gonzalez, Francesca Maremonti, Florian Gembardt, Nina Himmerkus, Markus Latk, Sophie Locke, Julian Marschner, Wenjun Li, Spencer Short, Sebastian Doll, Irina Ingold, Bettina Proneth, Christoph Daniel, Nazanin Kabgani, Rafael Kramann, Stephen Motika, Paul J. Hergenrother, Stefan R. Bornstein, Christian Hugo, Jan Ulrich Becker, Kerstin Amann, Hans-Joachim Anders, Daniel Kreisel, Derek Pratt, Michael Gütschow, Marcus Conrad and Andreas Linkermann. https://www.nature.com/articles/s41467-021-24712-6

Peroxisome-driven ether-linked phospholipids biosynthesis is essential for ferroptosis – Weiwei Cui, Dong Liu, Wei Gu and Bo Chu. https://www.nature.com/articles/s41418-021-00769-0

Obesity-Dependent Adipokine Chemerin Suppresses Fatty Acid Oxidation to Confer Ferroptosis Resistance – Sze Kiat Tan, Iqbal Mahmud, Flavia Fontanesi, Michelle Puchowicz, Chase K.A. Neumann, Anthony J. Griswold, Rutulkumar Patel, Marco Dispagna, Hamzah H. Ahmed, Mark L. Gonzalgo, J. Mark Brown, Timothy J. Garrett and Scott M. Welford. https://cancerdiscovery.aacrjournals.org/content/11/8/2072


Pyroptosis


RIPK1 activates distinct gasdermins in macrophages and neutrophils upon pathogen blockade of innate immune signaling – Kaiwen W. Chen, Benjamin Demarco, Saray Ramos, Rosalie Heilig, Michiel Goris, James P. Grayczyk, Charles-Antoine Assenmacher, Enrico Radaelli, Leonel D. Joannas, Jorge Henao-Mejia, Fabienne Tacchini-Cottier, Igor E. Brodsky, and Petr Broz. https://www.pnas.org/content/118/28/e2101189118.abstract

GSDME-mediated pyroptosis promotes inflammation and fibrosis in obstructive nephropathy – Yinshuang Li, Ying Yuan, Zhong-xing Huang, Hui Chen, Ruilong Lan, Zeng Wang, Kunmei Lai, Hong Chen, Zhimin Chen, Zhenhuan Zou, Hua-bin Ma, Hui-Yao Lan, Tak W. Mak and Yanfang Xu. https://www.nature.com/articles/s41418-021-00755-6


Miscellanous


Targeting multiple cell death pathways extends the shelf life and preserves the function of human and mouse neutrophils for transfusion – Yuping Fan , Yan Teng, Fabien Loison, Aiming Pang, Anongnard Kasorn, Xinqi Shao, Cunling Zhang, Qian Ren, Hongbo Yu, Yi Zheng, Jose A. Cancelas, John Manis, Li Chai, Shin-Young Park, Li Zhao, Yuanfu Xu, Sizhou Feng, Leslie E. Silberstein, Fengxia Ma, Hongbo R. Luo. https://stm.sciencemag.org/content/13/604/eabb1069

OAS1/RNase L executes RIG-I ligand–dependent tumor cell apoptosis – Daniel F. R. Boehmer , Simone Formisano, Carina C. de Oliveira Mann, Stephan A. Mueller, Michael Kluge, Philipp Metzger, Meino Rohlfs, Christine Hörth, Lorenz Kocheise, Stefan F. Lichtenthaler, Karl-Peter Hopfner, Stefan Endres, Simon Rothenfusser, Caroline C. Friedel, Peter Duewell, Max Schnurr, Lars M. Koenig. https://immunology.sciencemag.org/content/6/61/eabe2550

Plasma membrane permeabilization following cell death: many ways to dye! – Elke De Schutter, Benjamin Cappe, Bartosz Wiernicki, Peter Vandenabeele and Franck B. Riquet. https://www.nature.com/articles/s41420-021-00545-6


Reviews/comments


Molecular mechanisms of cell death in neurological diseases – Diane Moujalled, Andreas Strasser and Jeffrey R. Liddell. https://www.nature.com/articles/s41418-021-00814-y

Slow cell death helps tissue repair – Kim Baumann. https://www.nature.com/articles/s41580-021-00397-z

Targeting Bcl-2 for cancer therapy – Linlin Zhang, Zaiming Lu, Xiangxuan Zhao

https://www.sciencedirect.com/science/article/abs/pii/S0304419X21000664

Chemerin Tips the Scales in ccRCC to Evade Ferroptosis – Ed Reznik, Hui Jiang, and A. Ari Hakimi. https://cancerdiscovery.aacrjournals.org/content/11/8/1879


Cancer immunometabolism – EMBO Workshop

29 November – 01 December 2021 | Sitges, Barcelona, Spain – Hybrid conference

Organized by Cristina Muñoz Pinedo, Jean-Ehrland Ricci and Eric Eldering

https://meetings.embo.org/event/21-cancer

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