ApoList – September 2021


Bcl-2 family proteins


Lipids modulate the BH3-independent membrane targeting and activation of BAX and Bcl-xL – Victor Vasquez-Montes, Mykola V. Rodnin, Alexander Kyrychenko, and Alexey S. Ladokhin. https://www.pnas.org/content/118/37/e2025834118.abstract?etoc

A combinatorial drug screen in PDX-derived primary rhabdomyosarcoma cells identifies the NOXA – BCL-XL/MCL-1 balance as target for re-sensitization to first-line therapy in recurrent tumors – Gabriele Manzella, Devmini C. Moonamale, Michaela Römmele, Peter Bode, Marco Wachtel, Beat W. Schäfer. https://www.sciencedirect.com/science/article/pii/S1476558621000555#bbib0016


Death receptors, caspases and IAPs


Atrial natriuretic peptide promotes uterine decidualization and a TRAIL-dependent mechanism in spiral artery remodeling – Wei Zhang, Shuo Li, Jinglei Lou, Hui Li, Meng Liu, Ningzheng Dong, Qingyu Wu. https://www.jci.org/articles/view/151053

Development of a protein signature to enable clinical positioning of IAP inhibitors in colorectal cancer – Christopher McCann, Anna Matveeva, Katherine McAllister, Sandra Van Schaeybroeck, Tamas Sessler, Michael Fichtner, Steven Carberry, Markus Rehm, Jochen H.M. Prehn, Daniel B. Longley. https://febs.onlinelibrary.wiley.com/doi/full/10.1111/febs.15801

Non-apoptotic function of caspase-8 confers prostate cancer enzalutamide resistance via NF-κB activation – Jia Xia, Jiahui Zhang, Liangzhe Wang, Hailong Liu, Jie Wang, Junyan Liu, Zhaoqian Liu, Yingjian Zhu, Yingjie Xu, Wen Yang & Yongjiang Yu. https://www.nature.com/articles/s41419-021-04126-4


Necroptosis


Necroptosis activates UPR sensors without disrupting their binding with GRP78 – Wei Liang, Weiwei Qi, Yang Geng, Linhan Wang, Jing Zhao, Kezhou Zhu, Guowei Wu, Zairong Zhang, Heling Pan, Lihui Qian, and Junying Yuan. https://www.pnas.org/content/118/39/e2110476118

E3 ligase TRIM25 ubiquitinates RIP3 to inhibit TNF induced cell necrosis – Pucheng Mei, Feiyan Xie, Jiasong Pan, Sen Wang, Wenqing Gao et al.. https://www.nature.com/articles/s41418-021-00790-3

Gene interfered-ferroptosis therapy for cancers – Jinliang Gao, Tao Luo and Jinke Wang. https://www.nature.com/articles/s41467-021-25632-1


Efferocytosis, entosis etc


Amino acids and mechanistic target of rapamycin regulate the fate of live engulfed cells – Sung Eun Kim, Justin Zhang, Enoch Jiang, Michael Overholtzer. https://faseb.onlinelibrary.wiley.com/doi/10.1096/fj.202100870R

A secreted factor NimrodB4 promotes the elimination of apoptotic corpses by phagocytes in Drosophila – Bianca Petrignani, Samuel Rommelaere, Ketty Hakim-Mishnaevski, Florent Masson, Elodie Ramond, Reut Hilu-Dadia, Mickael Poidevin, Shu Kondo, Estee Kurant, Bruno Lemaitre. https://www.embopress.org/doi/full/10.15252/embr.202052262

Exposure of a specific pleioform of multifunctional glyceraldehyde 3-phosphate dehydrogenase initiates CD14-dependent clearance of apoptotic cells – Surbhi Chaudhary, Anil Patidar, Asmita Dhiman, Gaurav Kumar Chaubey, Rahul Dilawari, Sharmila Talukdar, Radheshyam Modanwal and Manoj Raje. https://www.nature.com/articles/s41419-021-04168-8


Miscellanous


AIM2 forms a complex with pyrin and ZBP1 to drive PANoptosis and host defence – SangJoon Lee, Rajendra Karki, Yaqiu Wang, Lam Nhat Nguyen, Ravi C. Kalathur and Thirumala-Devi Kanneganti. https://www.nature.com/articles/s41586-021-03875-8

UQCRC1 engages cytochrome c for neuronal apoptotic cell death – Yu-Chien Hung, Kuan-Lin Huang, Po-Lin Chen, Jeng-Lin Li, Serena Huei-An Lu, Jui-Chih Chang, Han-Yi Lin, Wen-Chun Lo, Shu-Yi Huang, Tai-Ting Lee, Tai-Yi Lin, Yuzuru Imai, Nobutaka Hattori, Chin-San Liu, Su-Yi Tsai, Chun-Hong Chen, Chin-Hsien Lin, Chih-Chiang Chan. https://www.cell.com/cell-reports/fulltext/S2211-1247(21)01178-5

Genetically encoded cell-death indicators (GEDI) to detect an early irreversible commitment to neurodegeneration – Jeremy W. Linsley, Kevan Shah, Nicholas Castello, Michelle Chan, Dominik Haddad, Zak Doric, Shijie Wang, Wiktoria Leks, Jay Mancini, Viral Oza, Ashkan Javaherian, Ken Nakamura, David Kokel and Steven Finkbeiner. https://www.nature.com/articles/s41467-021-25549-9


Reviews and comments


First we eat, then we do everything else: The dynamic metabolic regulation of efferocytosis – Alissa Trzeciak, Ya-Ting Wang, Justin Shaun Arnold Perry. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(21)00364-8

Mitochondrial regulation of ferroptosis – Boyi Gan. https://rupress.org/jcb/article-abstract/220/9/e202105043/212523/

Targeting ferroptosis in pancreatic cancer: a double-edged sword – Xin Chen, Rui Kang, Guido Kroemer, Daolin Tang. https://www.cell.com/trends/cancer/fulltext/S2405-8033(21)00097-2

Organelle-specific regulation of ferroptosis – Xin Chen, Rui Kang, Guido Kroemer and Daolin Tang. https://www.nature.com/articles/s41418-021-00859-z

Mechanism of interaction between autophagy and apoptosis in cancer – Shreya Das, Nidhi Shukla, Shashi Shekhar Singh, Sapana Kushwaha, Richa Shrivastava. https://link.springer.com/article/10.1007/s10495-021-01687-9

Kinases leave their mark on caspase substrates – Amy M. Weeks. https://portlandpress.com/biochemj/article/478/17/3179/229726

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