ApoList – June 2021


Efferocytosis and cell-cell effects


Collective ERK/Akt activity waves orchestrate epithelial homeostasis by driving apoptosis-induced survival – Paolo Armando Gagliardi, Maciej Dobrzyński, Marc-Antoine Jacques, Coralie Dessauges, Pascal Ender, Yannick Blum, Robert M. Hughes, Andrew R. Cohen, Olivier Pertz. https://www.cell.com/developmental-cell/fulltext/S1534-5807(21)00436-6

Robustness of epithelial sealing is an emerging property of local ERK feedback driven by cell elimination – Léo Valon, Anđela Davidović, Florence Levillayer, Alexis Villars, Mathilde Chouly, Fabiana Cerqueira-Campos, Romain Levayer. https://www.cell.com/developmental-cell/fulltext/S1534-5807(21)00435-4

Chemokines act as phosphatidylserine-bound “find-me” signals in apoptotic cell clearance – Sergio M. Pontejo, Philip M. Murphy. https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3001259

GPR34-mediated sensing of lysophosphatidylserine released by apoptotic neutrophils activates type 3 innate lymphoid cells to mediate tissue repair – Xiaqiong Wang, Juan Cai, Bolong Lin, Ming Ma, Ye Tao, Yubo Zhou, Li Bai, Wei Jiang, Rongbin Zhou. https://www.cell.com/immunity/fulltext/S1074-7613(21)00213-2

Efferocytosis by Paneth cells within the intestine – Laura S. Shankman, Samantha T. Fleury, W. Britt Evans, Kristen K. Penberthy, Sanja Arandjelovic, Richard S. Blumberg, Hervé Agaisse, Kodi S. Ravichandran. https://www.cell.com/current-biology/fulltext/S0960-9822(21)00428-0


Bcl-2 family proteins


Mitochondrial apoptotic priming is a key determinant of cell fate upon p53 restoration – Francisco J. Sánchez-Rivera, Jeremy Ryan, Yadira M. Soto-Feliciano, Mary Clare Beytagh, Lucius Xuan, David M. Feldser, Michael T. Hemann, Jesse Zamudio, Nadya Dimitrova, Anthony Letai, and Tyler Jacks. https://www.pnas.org/content/118/23/e2019740118.abstract?etoc

Stepwise activation of the pro-apoptotic protein Bid at mitochondrial membranes – Chien-Lun Hung, Hsin-Ho Chang, Su Wei Lee and Yun-Wei Chiang. https://www.nature.com/articles/s41418-020-00716-5

Pharmacological preconditioning protects from ischemia/reperfusion‐induced apoptosis by modulating Bcl‐xL expression through a ROS‐dependent mechanism – Romain Rozier, Rachel Paul, Blandine Madji Hounoum, Elodie Villa, Rana Mhaidly, Johanna Chiche, Els Verhoeyen, Sandrine Marchetti, Ashaina Vandenberghe, Marc Raucoules, Michel Carles, Jean-Ehrland Ricci. https://febs.onlinelibrary.wiley.com/doi/abs/10.1111/febs.15675

Metabolic perturbations sensitize triple-negative breast cancers to apoptosis induced by BH3 mimetics – Veerle W. Daniels , Jason J. Zoeller, Nick van Gastel, Kelley E. McQueeney, Salma Parvin, Danielle S. Potter, Geoffrey G. Fell, Vinícius G. Ferreira, Binyam Yilma, Rajat Gupta, Johan Spetz, Patrick D. Bhola, Jennifer E. Endress, Isaac S. Harris, Emanuel Carrilho, Kristopher A. Sarosiek, David T. Scadden, Joan S. Brugge, Anthony Letai. https://stke.sciencemag.org/content/14/686/eabc7405

Puma, noxa, p53, and p63 differentially mediate stress pathway induced apoptosis [in zebrafish] – Jun Wang, Holly R. Thomas, Zhang Li, Nan Cher (Florence) Yeo, Hannah E. Scott, Nghi Dang, Mohammed Iqbal Hossain, Shaida A. Andrabi and John M. Parant. https://www.nature.com/articles/s41419-021-03902-6


Death receptors


Hexavalent TRAIL Fusion Protein Eftozanermin Alfa Optimally Clusters Apoptosis-Inducing TRAIL Receptors to Induce On-Target Antitumor Activity in Solid Tumors – Darren C. Phillips, Fritz G. Buchanan, Dong Cheng, Larry R. Solomon, Yu Xiao, John Xue, Stephen K. Tahir, Morey L. Smith, Haichao Zhang, Deborah Widomski, Vivek C. Abraham, Nan Xu, Zhihong Liu, Li Zhou, Enrico DiGiammarino, Xin Lu, Nandini Rudra-Ganguly, Bruce Trela and Susan E. Morgan-Lappe. https://cancerres.aacrjournals.org/content/81/12/3402

Marizomib sensitizes primary glioma cells to apoptosis induced by a latest-generation TRAIL receptor agonist – Chiara Boccellato, Emily Kolbe, Nathalie Peters, Viktorija Juric, Gavin Fullstone, Maïté Verreault, Ahmed Idbaih, Martine L. M. Lamfers, Brona M. Murphy and Markus Rehm. https://www.nature.com/articles/s41419-021-03927-x

OPG/TRAIL ratio as a predictive biomarker of mortality in patients with type A acute aortic dissection – Jie Lu, Ping Li, Ke Ma, Yang Li, Hui Yuan, Junming Zhu, Weixun Duan, Jingsong Ou, Yonghong Huang, Long Wu, Xueliang Pan, Hui Zhang, Jie Du and Yulin Li. https://www.nature.com/articles/s41467-021-23787-5


Caspases


Caspase inhibition prolongs inflammation by promoting a signaling complex with activated RIPK1 – Xinyue Huang, Shuixia Tan, Yanxia Li, Shuangyi Cao, Xingyan Li, Heling Pan, Bing Shan, Lihui Qian, Junying Yuan. https://rupress.org/jcb/article-abstract/220/6/e202007127/212035

Rictor, an essential component of mTOR complex 2, undergoes caspase-mediated cleavage during apoptosis induced by multiple stimuli – Liqun Zhao, Lei Zhu, You-Take Oh, Guoqing Qian, Zhen Chen, Shi-Yong Sun. https://link.springer.com/article/10.1007/s10495-021-01676-y


Necroptosis


Ubiquitylation of MLKL at lysine 219 positively regulates necroptosis-induced tissue injury and pathogen clearance – Laura Ramos Garcia, Tencho Tenev, Richard Newman, Rachel O. Haich, Gianmaria Liccardi, Sidonie Wicky John, Alessandro Annibaldi, Lu Yu, Mercedes Pardo, Samuel N. Young, Cheree Fitzgibbon, Winnie Fernando, Naomi Guppy, Hyojin Kim, Lung-Yu Liang, Isabelle S. Lucet, Andrew Kueh, Ioannis Roxanis, Patrycja Gazinska, Martin Sims, Tomoko Smyth, George Ward, John Bertin, Allison M. Beal, Brad Geddes, Jyoti S. Choudhary, James M. Murphy, K. Aurelia Ball, Jason W. Upton and Pascal Meier. https://www.nature.com/articles/s41467-021-23474-5

The MLKL kinase-like domain dimerization is an indispensable step of mammalian MLKL activation in necroptosis signaling – Yu Zhang, Jia Liu, Dandan Yu, Xinxin Zhu, Xiaoyan Liu, Jun Liao, Sheng Li and Huayi Wang. https://www.nature.com/articles/s41419-021-03859-6

NF-κB inhibition in keratinocytes causes RIPK1-mediated necroptosis and skin inflammation – Snehlata Kumari, Trieu-My Van, Daniela Preukschat, Hannah Schuenke, Marijana Basic, André Bleich, Ulf Klein and Manolis Pasparakis. https://www.life-science-alliance.org/content/4/6/e202000956.abstract


Pyroptosis


The lysosomal Rag-Ragulator complex licenses RIPK1– and caspase-8–mediated pyroptosis by Yersinia – Zengzhang Zheng, Wanyan Deng, Yang Bai, Rui Miao, Shenglin Mei, Zhibin Zhang, Youdong Pan, Yi Wang, Rui Min, Fan Deng, Zeyu Wu, Wu Li, Pengcheng Chen, Tianchi Ma, Xiwen Lou, Judy Lieberman, Xing Liu. https://science.sciencemag.org/content/372/6549/eabg0269

Gasdermin-E-mediated pyroptosis participates in the pathogenesis of Crohn’s disease by promoting intestinal inflammation – Gao Tan, Chongyang Huang, Jiaye Chen, Bingxia Chen, Fachao Zhi. https://www.cell.com/cell-reports/fulltext/S2211-1247(21)00632-X

Ischemia reperfusion injury induces pyroptosis and mediates injury in steatotic liver thorough Caspase 1 activation – Vasantha L. Kolachala, Chrissy Lopez, Ming Shen, Dmitry Shayakhmetov, Nitika Arora Gupta. https://link.springer.com/article/10.1007/s10495-021-01673-1


Ferroptosis


Oxygenated phosphatidylethanolamine navigates phagocytosis of ferroptotic cells by interacting with TLR2 – Xiang Luo, Hai-Biao Gong, Hua-Ying Gao, Yan-Ping Wu, Wan-Yang Sun, Zheng-Qiu Li, Guan Wang, Bo Liu, Lei Liang, Hiroshi Kurihara, Wen-Jun Duan, Yi-Fang Li and Rong-Rong He. https://www.nature.com/articles/s41418-020-00719-2


Cell death and immunity


Functional heterogeneity of cytotoxic T cells and tumor resistance to cytotoxic hits limit anti‐tumor activity in vivo – Roxana Khazen, Marine Cazaux, Fabrice Lemaître, Beatrice Corre, Zacarias Garcia, Philippe Bousso. https://www.embopress.org/doi/abs/10.15252/embj.2020106658

Pathogenic ubiquitination of GSDMB inhibits NK cell bactericidal functions – Justin M. Hansen, Maarten F. de Jong, Qi Wu, Li-Shu Zhang, David B. Heisler, Laura T. Alto, Neal M. Alto. https://www.cell.com/cell/fulltext/S0092-8674(21)00571-7

TAK1 inhibition elicits mitochondrial ROS to block intracellular bacterial colonization – Wilfred López-Pérez, Kazuhito Sai, Yosuke Sakamachi, Cameron Parsons, Sophia Kathariou, and Jun Ninomiya-Tsuji. https://www.pnas.org/content/118/25/e2023647118.abstract?etoc


Miscellanous


A unique mode of keratinocyte death requires intracellular acidification – Takeshi Matsui, Nanako Kadono-Maekubo, Yoshiro Suzuki, Yuki Furuichi, Keiichiro Shiraga, Hiroyuki Sasaki, Azusa Ishida, Sonoko Takahashi, Takaharu Okada, Kiminori Toyooka, Jafar Sharif, Takaya Abe, Hiroshi Kiyonari, Makoto Tominaga, Atsushi Miyawaki, Masayuki Amagai. https://www.pnas.org/content/118/17/e2020722118

Targeting highly pathogenic coronavirus-induced apoptosis reduces viral pathogenesis and disease severity – Hin Chu , Huiping Shuai, Yuxin Hou, Xi Zhang, Lei Wen, Xiner Huang, Bingjie Hu, Dong Yang, Yixin Wang, Chaemin Yoon, Bosco Ho-Yin Wong, Cun Li, Xiaoyu Zhao, Vincent Kwok-Man Poon, Jian-Piao Cai, Kenneth Kak-Yuen Wong, Man-Lung Yeung, Jie Zhou, Rex Kwok-Him Au-Yeung, Shuofeng Yuan, Dong-Yan Jin, Kin-Hang Kok, Stanley Perlman, Jasper Fuk-Woo Chan, Kwok-Yung Yuen. https://advances.sciencemag.org/content/7/25/eabf8577


Reviews


Too much death can kill you: inhibiting intrinsic apoptosis to treat disease – Kaiming Li, Mark F van Delft, Grant Dewson. https://www.embopress.org/doi/abs/10.15252/embj.2020107341

Great balls of fire: activation and signalling of inflammatory caspases – Georgia Bateman, Benjamin Hill, Ryan Knight, Dave Boucher. https://portlandpress.com/biochemsoctrans/article/doi/10.1042/BST20200986/228851

MLKL in cancer: more than a necroptosis regulator – Sofie Martens, Jolien Bridelance, Ria Roelandt, Peter Vandenabeele and Nozomi Takahashi. https://www.nature.com/articles/s41418-021-00785-0

NET formation – mechanisms and how they relate to other cell death pathways – Thibault Rosazza, Jordan Warner, Gabriel Sollberger. https://febs.onlinelibrary.wiley.com/doi/full/10.1111/febs.15589

Putting the brakes on phagocytosis: “don’t‐eat‐me” signaling in physiology and disease – Shannon M Kelley, Kodi S Ravichandran. https://www.embopress.org/doi/abs/10.15252/embr.202152564

Ferroptosis in infection, inflammation, and immunity – Xin Chen; Rui Kang; Guido Kroemer; Daolin Tang. https://rupress.org/jem/article-abstract/218/6/e20210518/212093

The role of P53 up-regulated modulator of apoptosis (PUMA) in ovarian development, cardiovascular and neurodegenerative diseases – Mei Li. https://link.springer.com/article/10.1007/s10495-021-01667-z


Comments


Death in the Fas, ELANE – Anthony Letai. https://www.cell.com/cell/fulltext/S0092-8674(21)00654-1

Functional cell death, corneoptosis, requires temporally controlled intracellular acidification – Jessica L. Moore and Valentina Greco. https://www.pnas.org/content/118/22/e2106633118

Distributing apoptosis protects epithelia – Annalisa M. VanHook. https://stke.sciencemag.org/content/14/689/eabk1364

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