ApoList – May 2021


Bcl-2 family proteins


Regulation of Bcl-XL by non-canonical NF-κB in the context of CD40-induced drug resistance in CLL – Marco Haselager, Rachel Thijssen, Christopher West, Louise Young, Roel Van Kampen, Elaine Willmore, Simon Mackay, Arnon Kater and Eric Eldering. https://www.nature.com/articles/s41418-020-00692-w

CRISPR screens identify a novel combination treatment targeting BCL-XL and WNT signaling for KRAS/BRAF-mutated colorectal cancers – Hae Rim Jung, Yumi Oh, Deukchae Na, Seoyeon Min, Jinjoo Kang, Dongjun Jang, Seungjae Shin, Jiwon Kim, Sang Eun Lee, Eui Man Jeong, Joon Yong An, Chang Ohk Sung, Won-Suk Lee, Charles Lee and Sung-Yup Cho. https://www.nature.com/articles/s41388-021-01777-7

A novel BH3-mimetic, AZD0466, targeting BCL-XL and BCL-2 is effective in pre-clinical models of malignant pleural mesothelioma – Surein Arulananda, Megan O’Brien, Marco Evangelista, Laura J. Jenkins, Ashleigh R. Poh, Marzena Walkiewicz, Trishe Leong, John M. Mariadason, Jonathan Cebon, Srividya B. Balachander, Justin R. Cidado, Erinna F. Lee, Thomas John and Walter D. Fairlie. https://www.nature.com/articles/s41420-021-00505-0

Endogenous Retroelement Activation by Epigenetic Therapy Reverses the Warburg Effect and Elicits Mitochondrial-Mediated Cancer Cell Death – Vicente Fresquet, Maria J. Garcia-Barchino, Marta Larrayoz, Jon Celay, Carmen Vicente, Marta Fernandez-Galilea, Maria J. Larrayoz, Maria J. Calasanz, Carlos Panizo, Alexandra Junza, Jiahuai Han, Celia Prior, Puri Fortes, Ruben Pio, Julen Oyarzabal, Alvaro Martinez-Baztan, Bruno Paiva, Maria J. Moreno-Aliaga, Maria D. Odero, Xabier Agirre, Oscar Yanes, Felipe Prosper and Jose A. Martinez-Climent. https://cancerdiscovery.aacrjournals.org/content/11/5/1268

Antiapoptotic Bcl-2 family proteins BCL-xL and MCL-1 integrate neural progenitor survival and proliferation during postnatal cerebellar neurogenesis – Katherine A. Veleta, Abigail H. Cleveland, Benjamin R. Babcock, You-Wen He, Duhyeong Hwang, Marina Sokolsky-Papkov and Timothy R. Gershon. https://www.nature.com/articles/s41418-020-00687-7

BAD regulates mammary gland morphogenesis by 4E-BP1-mediated control of localized translation in mouse and human models – John Maringa Githaka, Namita Tripathi, Raven Kirschenman, Namrata Patel, Vrajesh Pandya, David A. Kramer, Rachel Montpetit, Lin Fu Zhu, Nahum Sonenberg, Richard P. Fahlman, Nika N. Danial, D. Alan Underhill and Ing Swie Goping. https://www.nature.com/articles/s41467-021-23269-8


Death receptors


TNF controls a speed-accuracy tradeoff in the cell death decision to restrict viral spread – Jennifer Oyler-Yaniv, Alon Oyler-Yaniv, Evan Maltz and Roy Wollman. https://www.nature.com/articles/s41467-021-23195-9

Generation of TRAIL-resistant cell line models reveals distinct adaptive mechanisms for acquired resistance and re-sensitization – Ahmet Cingöz, Ezgi Ozyerli-Goknar, Tunc Morova, Fidan Seker-Polat, Myvizhi Esai Selvan, Zeynep Hülya Gümüş, Deepak Bhere, Khalid Shah, Ihsan Solaroglu and Tugba Bagci-Onder. https://www.nature.com/articles/s41388-021-01697-6

CDK2-Mediated Upregulation of TNFα as a Mechanism of Selective Cytotoxicity in Acute Leukemia – Husheng Ding, Nicole D. Vincelette, Cordelia D. McGehee, Mira A. Kohorst, Brian D. Koh, Annapoorna Venkatachalam, X. Wei Meng, Paula A. Schneider, Karen S. Flatten, Kevin L. Peterson, Cristina Correia, Sun-Hee Lee, Mrinal Patnaik, Jonathan A. Webster, Gabriel Ghiaur, B. Douglas Smith, Judith E. Karp, Keith W. Pratz, Hu Li, Larry M. Karnitz and Scott H. Kaufmann. https://cancerres.aacrjournals.org/content/81/10/2666


Caspases and IAPs


Evaluation of the effects of phosphorylation of synthetic peptide substrates on their cleavage by caspase-3 and -7 – Izabela Maluch, Justyna Grzymska, Scott Snipas, Guy S Salvesen, Marcin Drag. https://portlandpress.com/biochemj/article/doi/10.1042/BCJ20210255/228758/

Moderate DNA hypomethylation suppresses intestinal tumorigenesis by promoting caspase-3 expression and apoptosis – Xiaoya Duan, Yuanyong Huang, Xiaoxing Chen, Wencai Wang, Jiwei Chen, Jialun Li, Wei Yang, Jiwen Li, Qihan Wu and Jiemin Wong. https://www.nature.com/articles/s41389-021-00328-9

cIAP1/2 antagonism eliminates MHC class I–negative tumors through T cell–dependent reprogramming of mononuclear phagocytes – Kevin Roehle , Li Qiang, Katherine S. Ventre, Daniel Heid, Lestat R. Ali, Patrick Lenehan, Max Heckler, Stephanie J. Crowley, Courtney T. Stump, Gabrielle Ro, Anže Godicelj, Aladdin M. Bhuiyan, Annan Yang, Maria Quiles del Rey, Tamara Biary, Adrienne M. Luoma, Patrick T. Bruck, Jana F. Tegethoff, Svenja L. Nopper, Jinyang Li, Katelyn T. Byrne, Marc Pelletier, Kai W. Wucherpfennig, Ben Z. Stanger, James J. Akin, Joseph D. Mancias, Judith Agudo, Michael Dougan, Stephanie K. Dougan. https://stm.sciencemag.org/content/13/594/eabf5058


Necroptosis


ZBP1 not RIPK1 mediates tumor necroptosis in breast cancer – Jin Young Baik, Zhaoshan Liu, Delong Jiao, Hyung-Joon Kwon, Jiong Yan, Chamila Kadigamuwa, Moran Choe, Ross Lake, Michael Kruhlak, Mayank Tandon, Zhenyu Cai, Swati Choksi and Zheng-gang Liu. https://www.nature.com/articles/s41467-021-23004-3

Necroptosis is dispensable for the development of inflammation-associated or sporadic colon cancer in mice – Silvia Alvarez-Diaz, Adele Preaudet, Andre L. Samson, Paul M. Nguyen, Ka Yee Fung, Alexandra L. Garnham, Warren S. Alexander, Andreas Strasser, Matthias Ernst, Tracy L. Putoczki and James M. Murphy. https://www.nature.com/articles/s41418-020-00673-z

RIPK1 activation mediates neuroinflammation and disease progression in multiple sclerosis – Matija Zelic, Fabrizio Pontarelli, Lisa Woodworth, Cheng Zhu, Amy Mahan, Yi Ren, Michael LaMorte, Ross Gruber, Aislinn Keane, Pequita Loring, Lilu Guo, Tai-he Xia, Boyao Zhang, Pontus Orning, Egil Lien, Alexei Degterev, Timothy Hammond, Dimitry Ofengeim. https://www.cell.com/cell-reports/fulltext/S2211-1247(21)00446-0

Primidone blocks RIPK1-driven cell death and inflammation – Theresa Riebeling, Kunzah Jamal, Rebecca Wilson, Benedikt Kolbrink, Friedrich Alexander von Samson-Himmelstjerna, Caroline Moerke, Laura Ramos Garcia, Eileen Dahlke, Friederike Michels, Fred Lühder, Domagoj Schunk, Philipp Doldi, Bartosz Tyczynski, Andreas Kribben, Charlotte Flüh, Franziska Theilig, Ulrich Kunzendorf, Pascal Meier and Stefan Krautwald. https://www.nature.com/articles/s41418-020-00690-y


Ferroptosis


Ferroptotic pores induce Ca2+ fluxes and ESCRT-III activation to modulate cell death kinetics – Lohans Pedrera, Rafael A. Espiritu, Uris Ros, Josephine Weber, Anja Schmitt, Jenny Stroh, Stephan Hailfinger, Silvia von Karstedt and Ana J. García-Sáez. https://www.nature.com/articles/s41418-020-00691-x

CD36-mediated ferroptosis dampens intratumoral CD8+ T cell effector function and impairs their antitumor ability – Xingzhe Ma, Liuling Xiao, Lintao Liu, Lingqun Ye, Pan Su, Enguang Bi, Qiang Wang, Maojie Yang, Jianfei Qian, Qing Yi. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(21)00071-1

DHODH-mediated ferroptosis defence is a targetable vulnerability in cancer – Chao Mao, Xiaoguang Liu, Yilei Zhang, Guang Lei, Yuelong Yan, Hyemin Lee, Pranavi Koppula, Shiqi Wu, Li Zhuang, Bingliang Fang, Masha V. Poyurovsky, Kellen Olszewski and Boyi Gan. https://www.nature.com/articles/s41586-021-03539-7

The mitochondrial Ca2+ uptake regulator, MICU1, is involved in cold stress‐induced ferroptosis – Toshitaka Nakamura, Motoyuki Ogawa, Kazuki Kojima, Saki Takayanagi, Shunya Ishihara, Kazuki Hattori, Isao Naguro, Hidenori Ichijo. https://www.embopress.org/doi/abs/10.15252/embr.202051532

Ferroptosis as a mechanism to mediate p53 function in tumor radiosensitivity – Guang Lei, Yilei Zhang, Ting Hong, Xudong Zhang, Xiaoguang Liu, Chao Mao, Yuelong Yan, Pranavi Koppula, Weijie Cheng, Anil K. Sood, Jinsong Liu and Boyi Gan. https://www.nature.com/articles/s41388-021-01790-w

Loss of ferroportin induces memory impairment by promoting ferroptosis in Alzheimer’s disease – Wen-Dai Bao, Pei Pang, Xiao-Ting Zhou, Fan Hu, Wan Xiong, Kai Chen, Jing Wang, Fudi Wang, Dong Xie, Ya-Zhuo Hu, Zhi-Tao Han, Hong-Hong Zhang, Wang-Xia Wang, Peter T. Nelson, Jian-Guo Chen, Youming Lu, Heng-Ye Man, Dan Liu and Ling-Qiang Zhu. https://www.nature.com/articles/s41418-020-00685-9


Efferocytosis, entosis etc


Replication stress promotes cell elimination by extrusion – Vivek K. Dwivedi, Carlos Pardo-Pastor, Rita Droste, Ji Na Kong, Nolan Tucker, Daniel P. Denning, Jody Rosenblatt and H. Robert Horvitz. https://www.nature.com/articles/s41586-021-03526-y

DNase II mediates a parthanatos-like developmental cell death pathway in Drosophila primordial germ cells – Lama Tarayrah-Ibraheim, Elital Chass Maurice, Guy Hadary, Sharon Ben-Hur, Alina Kolpakova, Tslil Braun, Yoav Peleg, Keren Yacobi-Sharon and Eli Arama. https://www.nature.com/articles/s41467-021-22622-1

PI3KC3 complex subunit NRBF2 is required for apoptotic cell clearance to restrict intestinal inflammation – Ming-Yue Wu, Le Liu, Er-Jin Wang, Hai-Tao Xiao, Cui-Zan Cai, Jing Wang, Huanxing Su, Yitao Wang, Jieqiong Tan, Zhuohua Zhang, Juan Wang, Maojing Yao, De-Fang Ouyang, Zhenyu Yue, Min Li, Ye Chen, Zhao-Xiang Bian and Jia-Hong Lu. https://www.tandfonline.com/doi/abs/10.1080/15548627.2020.1741332


Miscellanous


BNIP3 promotes HIF‐1α‐driven melanoma growth by curbing intracellular iron homeostasis – Mónica Vara-Pérez, Matteo Rossi, Chris Van den Haute, Hannelore Maes, Maria Livia Sassano, Vivek Venkataramani, Bernhard Michalke, Erminia Romano, Kristine Rillaerts, Abhishek D Garg, Corentin Schepkens, Francesca M Bosisio, Jasper Wouters, Ana Isabel Oliveira, Peter Vangheluwe, Wim Annaert, Johannes V Swinnen, Jean Marie Colet, Joost J van den Oord, Sarah-Maria Fendt, Massimiliano Mazzone, Patrizia Agostinis. https://www.embopress.org/doi/full/10.15252/embj.2020106214


Reviews


Punching Holes in Cellular Membranes: Biology and Evolution of Gasdermins – Elke De Schutter, Ria Roelandt, Franck B. Riquet, Guy Van Camp, Andy Wullaert, Peter Vandenabeele. https://www.cell.com/trends/cell-biology/fulltext/S0962-8924(21)00050-7

Mechanistic connections between mitochondrial biology and regulated cell death – Jerry Edward Chipuk, Jarvier N. Mohammed, Jesse D. Gelles, Yiyang Chen. https://www.cell.com/developmental-cell/fulltext/S1534-5807(21)00308-7

Open questions on the mitochondrial unfolded protein response – Friederike‐Nora Vögtle. https://febs.onlinelibrary.wiley.com/doi/full/10.1111/febs.15569

The importance of transmembrane domain interactions in the viral control of apoptosis – Gerard Duart, Ismael Mingarro and Luis Martinez-Gil. https://www.tandfonline.com/doi/full/10.1080/23723556.2021.1911290

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