Bcl-2 family proteins
MCL-1 gains occur with high frequency in lung adenocarcinoma and can be targeted therapeutically – Enkhtsetseg Munkhbaatar, Michelle Dietzen, Deepti Agrawal, Martina Anton, Moritz Jesinghaus, Melanie Boxberg, Nicole Pfarr, Pidassa Bidola, Sebastian Uhrig, Ulrike Höckendorf, Anna-Lena Meinhardt, Adam Wahida, Irina Heid, Rickmer Braren, Ritu Mishra, Arne Warth, Thomas Muley, Patrina S. P. Poh, Xin Wang, Stefan Fröhling, Katja Steiger, Julia Slotta-Huspenina, Martijn van Griensven, Franz Pfeiffer, Sebastian Lange, Roland Rad, Magda Spella, Georgios T. Stathopoulos, Jürgen Ruland, Florian Bassermann, Wilko Weichert, Andreas Strasser, Caterina Branca, Mathias Heikenwalder, Charles Swanton, Nicholas McGranahan and Philipp J. Jost. https://www.nature.com/articles/s41467-020-18372-1
The structural basis of Bcl-2 mediated cell death regulation in hydra – Suresh Banjara, Jaison D Sa, Mark G. Hinds, Marc Kvansakul. https://portlandpress.com/biochemj/article/477/17/3287/226037
JNK1 and ERK1/2 modulate lymphocyte homeostasis via BIM and DRP1 upon AICD induction – Luca Simula, Mauro Corrado, Benedetta Accordi, Anthea Di Rita, Francesca Nazio, Ylenia Antonucci, Arianna Di Daniele, Federico Caicci, Ignazio Caruana, Maria Eugenia Soriano, Martina Pigazzi, Franco Locatelli, Francesco Cecconi and Silvia Campello. https://www.nature.com/articles/s41418-020-0540-1
Apoptotic stress induces Bax-dependent, caspase-independent redistribution of LINC complex nesprins – Liora Lindenboim, Dan Grozki, Ayelet R. Amsalem-Zafran, Aida Peña-Blanco, Gregg G. Gundersen, Christoph Borner, Didier Hodzic, Ana J. Garcia-Sáez, Howard J. Worman and Reuven Stein. https://www.nature.com/articles/s41420-020-00327-6
Modeling the function of BAX and BAK in early human brain development using iPSC-derived systems – Piyush Joshi, Caroline Bodnya, Megan L. Rasmussen, Alejandra I. Romero-Morales, Anna Bright and Vivian Gama. https://www.nature.com/articles/s41419-020-03002-x
BDA-366, a putative Bcl-2 BH4 domain antagonist, induces apoptosis independently of Bcl-2 in a variety of cancer cell models – Tamara Vervloessem, Binu K. Sasi, Elena Xerxa, Spyridoula Karamanou, Justin Kale, Rita M. La Rovere, Supriya Chakraborty, Flore Sneyers, Meike Vogler, Anastassios Economou, Luca Laurenti, David W. Andrews, Dimitar G. Efremov and Geert Bultynck. https://www.nature.com/articles/s41419-020-02944-6
CHIP ubiquitylates NOXA and induces its lysosomal degradation in response to DNA damage – Marie-Christine Albert, Kerstin Brinkmann, Wojciech Pokrzywa, Saskia Diana Günther, Martin Krönke, Thorsten Hoppe and Hamid Kashkar. https://www.nature.com/articles/s41419-020-02923-x
Immunity / infection
Functional genomic landscape of cancer-intrinsic evasion of killing by T cells – Keith A. Lawson, Cristovão M. Sousa, Xiaoyu Zhang, Eiru Kim, Rummy Akthar, Joseph J. Caumanns, Yuxi Yao, Nicholas Mikolajewicz, Catherine Ross, Kevin R. Brown, Abdelrahman Abou Zid, Zi Peng Fan, Shirley Hui, Jordan A. Krall, Donald M. Simons, Chloe J. Slater, Victor De Jesus, Lujia Tang, Richa Singh, Joshua E. Goldford, Sarah Martin, Qian Huang, Elizabeth A. Francis, Andrea Habsid, Ryan Climie, David Tieu, Jiarun Wei, Ren Li, Amy Hin Yan Tong, Michael Aregger, Katherine S. Chan, Hong Han, Xiaowei Wang, Patricia Mero, John H. Brumell, Antonio Finelli, Laurie Ailles, Gary Bader, Gromoslaw A. Smolen, Gillian A. Kingsbury, Traver Hart, Charles Kung and Jason Moffat. https://www.nature.com/articles/s41586-020-2746-2
Structural insight into tanapoxvirus‐mediated inhibition of apoptosis – Chathura D. Suraweera, Mohd Ishtiaq Anasir, Srishti Chugh, Airah Javorsky, Rachael E. Impey, Mohammad Hasan Zadeh, Tatiana P. Soares da Costa, Mark G. Hinds, Marc Kvansakul. https://febs.onlinelibrary.wiley.com/doi/abs/10.1111/febs.15365
A unique bacterial tactic to circumvent the cell death crosstalk induced by blockade of caspase‐8 – Hiroshi Ashida, Chihiro Sasakawa, Toshihiko Suzuki. https://www.embopress.org/doi/full/10.15252/embj.2020104469
Death receptors / necroptosis
Modulating TRADD to restore cellular homeostasis and inhibit apoptosis – Daichao Xu, Heng Zhao, Minzhi Jin, Hong Zhu, Bing Shan, Jiefei Geng, Slawomir A. Dziedzic, Palak Amin, Lauren Mifflin, Masanori Gomi Naito, Ayaz Najafov, Jing Xing, Lingjie Yan, Jianping Liu, Ying Qin, Xinqian Hu, Huibing Wang, Mengmeng Zhang, Vica Jean Manuel, Li Tan, Zhuohao He, Zhenyu J. Sun, Virginia M. Y. Lee, Gerhard Wagner and Junying Yuan. https://www.nature.com/articles/s41586-020-2757-z
Reduction in MLKL-mediated endosomal trafficking enhances the TRAIL-DR4/5 signal to increase cancer cell death – Se-Yeon Park, Han-Hee Park, Sang-Yeong Park, Sun Mi Hong, Seongmin Yoon, Michael J. Morgan and You-Sun Kim. https://www.nature.com/articles/s41419-020-02941-9
Caspases and IAPs
The apoptosome molecular timer synergises with XIAP to suppress apoptosis execution and contributes to prognosticating survival in colorectal cancer – Gavin Fullstone, Tabea L. Bauer, Cristiano Guttà, Manuela Salvucci, Jochen H. M. Prehn and Markus Rehm. https://www.nature.com/articles/s41418-020-0545-9
Targeting triple-negative breast cancers with the Smac-mimetic birinapant – Najoua Lalaoui, Delphine Merino, Goknur Giner, François Vaillant, Diep Chau, Lin Liu, Tobias Kratina, Bhupinder Pal, James R. Whittle, Nima Etemadi, Jean Berthelet, Julius Gräsel, Cathrine Hall, Matthew E. Ritchie, Matthias Ernst, Gordon K. Smyth, David L. Vaux, Jane E. Visvader, Geoffrey J. Lindeman and John Silke. https://www.nature.com/articles/s41418-020-0541-0
CASP9 (caspase 9) is essential for autophagosome maturation through regulation of mitochondrial homeostasis – Hyun-Kyu An, Kyung Min Chung, Hyunhee Park, Jihyun Hong, Ji-Eun Gim, Hyosun Choi, Ye Won Lee, Jieun Choi, Ji Young Mun and Seong-Woon Yu. https://www.tandfonline.com/doi/abs/10.1080/15548627.2019.1695398
Pyroptosis
Succination inactivates gasdermin D and blocks pyroptosis – Fiachra Humphries, Liraz Shmuel-Galia, Natalia Ketelut-Carneiro, Sheng Li, Bingwei Wang, Venkatesh V. Nemmara, Ruth Wilson, Zhaozhao Jiang, Farnaz Khalighinejad, Khaja Muneeruddin, Scott A. Shaffer, Ranjan Dutta, Carolina Ionete, Scott Pesiridis, Shuo Yang, Paul R. Thompson, Katherine A. Fitzgerald. https://science.sciencemag.org/content/369/6511/1633
Caspase-8 mediates inflammation and disease in rodent malaria – Larissa M. N. Pereira, Patrícia A. Assis, Natalia M. de Araújo, Danielle F. Durso, Caroline Junqueira, Marco Antônio Ataíde, Dhelio B. Pereira, Egil Lien, Katherine A. Fitzgerald, Dario S. Zamboni, Douglas T. Golenbock and Ricardo T. Gazzinelli. https://www.nature.com/articles/s41467-020-18295-x
Indirect regulation of HMGB1 release by gasdermin D – Allen Volchuk, Anna Ye, Leon Chi, Benjamin E. Steinberg and Neil M. Goldenberg. https://www.nature.com/articles/s41467-020-18443-3
Ferroptosis
Plasticity of ether lipids promotes ferroptosis susceptibility and evasion – Yilong Zou, Whitney S. Henry, Emily L. Ricq, Emily T. Graham, Vaishnavi V. Phadnis, Pema Maretich, Sateja Paradkar, Natalie Boehnke, Amy A. Deik, Ferenc Reinhardt, John K. Eaton, Bryan Ferguson, Wenyu Wang, Joshua Fairman, Heather R. Keys, Vlado Dančík, Clary B. Clish, Paul A. Clemons, Paula T. Hammond, Laurie A. Boyer, Robert A. Weinberg and Stuart L. Schreiber. https://www.nature.com/articles/s41586-020-2732-8
Alpha synuclein aggregation drives ferroptosis: an interplay of iron, calcium and lipid peroxidation – Plamena R. Angelova, Minee L. Choi, Alexey V. Berezhnov, Mathew H. Horrocks, Craig D. Hughes, Suman De, Margarida Rodrigues, Ratsuda Yapom, Daniel Little, Karamjit S. Dolt, Tilo Kunath, Michael J. Devine, Paul Gissen, Mikhail S. Shchepinov, Sergiy Sylantyev, Evgeny V. Pavlov, David Klenerman, Andrey Y. Abramov and Sonia Gandhi. https://www.nature.com/articles/s41418-020-0542-z
Miscellanous
Diversifying the platinum-based chemotherapy toolkit for immunogenic cancer cell death – Abhishek D. Garg and Patrizia Agostinis. https://impactjournals.us9.list-manage.com/track/click?u=133779c099e52b6fa9d4dec2e&id=1561a2e654&e=923b339f12
The antitumour drug ABTL0812 impairs neuroblastoma growth through endoplasmic reticulum stress-mediated autophagy and apoptosis – Laia París-Coderch, Aroa Soriano, Carlos Jiménez, Tatiana Erazo, Pau Muñoz-Guardiola, Marc Masanas, Roberta Antonelli, Ariadna Boloix, José Alfón, Héctor Pérez-Montoyo, Marc Yeste-Velasco, Carles Domènech, Josep Roma, Josep Sánchez de Toledo, Lucas Moreno, José M. Lizcano, Soledad Gallego and Miguel F. Segura. https://www.nature.com/articles/s41419-020-02986-w
Reviews / comments
Together we stand, apart we fall: how cell-to-cell contact/interplay provides resistance to ferroptosis – Milica Vucetic, Boutaina Daher, Shamir Cassim, Willian Meira and Jacques Pouyssegur. https://www.nature.com/articles/s41419-020-02994-w
The BCL-2 family saga – Ana J. García-Sáez. https://www.nature.com/articles/s41580-020-0276-2
Preventing pores and inflammation – Robert J. Pickering, Clare E. Bryant. https://science.sciencemag.org/content/369/6511/1564
