ApoList – August 2020


Bcl-2 family proteins


Venetoclax causes metabolic reprogramming independent of BCL-2 inhibition – Alba Roca-Portoles, Giovanny Rodriguez-Blanco, David Sumpton, Catherine Cloix, Margaret Mullin, Gillian M. Mackay, Katelyn O’Neill, Leandro Lemgruber, Xu Luo and Stephen W. G. Tait. https://www.nature.com/articles/s41419-020-02867-2

Sequential combinations of chemotherapeutic agents with BH3 mimetics to treat rhabdomyosarcoma and avoid resistanceClara Alcon, Albert Manzano-Muñoz, Estela Prada, Jaume Mora, Aroa Soriano, Gabriela Guillén, Soledad Gallego, Josep Roma, Josep Samitier, Alberto Villanueva and Joan Montero. https://www.nature.com/articles/s41419-020-02887-y

Dual Targeting of CDK4/6 and BCL2 Pathways Augments Tumor Response in Estrogen Receptor–Positive Breast Cancer – James R. Whittle, François Vaillant, Elliot Surgenor, Antonia N. Policheni, Göknur Giner, Bianca D. Capaldo, Huei-Rong Chen, He K. Liu, Johanna F. Dekkers, Norman Sachs, Hans Clevers, Andrew Fellowes, Thomas Green, Huiling Xu, Stephen B. Fox, Marco J. Herold, Gordon K. Smyth, Daniel H.D. Gray, Jane E. Visvader and Geoffrey J. Lindeman. https://clincancerres.aacrjournals.org/content/26/15/4120

Integrated analysis of patient samples identifies biomarkers for venetoclax efficacy and combination strategies in acute myeloid leukemia – Haijiao Zhang, Yusuke Nakauchi, Thomas Köhnke, Melissa Stafford, Daniel Bottomly, Rozario Thomas, Beth Wilmot, Shannon K. McWeeney, Ravindra Majeti and Jeffrey W. Tyner. https://www.nature.com/articles/s43018-020-0103-x

ATG16L1 autophagy pathway regulates BAX protein levels and programmed cell death – Fenfen Chen, Dulguun Amgalan, Richard N. Kitsis, Jeffrey E. Pessin and Daorong Feng. http://www.jbc.org/content/early/2020/08/26/jbc.RA120.013999.abstract

The BCL-2 selective inhibitor ABT-199 sensitizes soft tissue sarcomas to proteasome inhibition by a concerted mechanism requiring BAX and NOXA – Alina Muenchow, Sandra Weller, Clemens Hinterleitner, Elke Malenke, Stefanie Bugl, Stefan Wirths, Martin R. Müller, Klaus Schulze-Osthoff, Walter E. Aulitzky, Hans-Georg Kopp and Frank Essmann. https://www.nature.com/articles/s41419-020-02910-2


Death receptors


A TRAIL-TL1A Paracrine Network Involving Adipocytes, Macrophages and lymphocytes Induces Adipose Tissue Dysfunction Downstream of E2F1 in Human Obesity – Nitzan Maixner, Tal Pecht, Yulia Haim, Vered Chalifa-Caspi, Nir Goldstein, Tania Tarnovscki, Idit F. Liberty, Boris Kirshtein, Rachel Golan, Omer Berner, Alon Monsonego, Nava Bashan, Matthias Blüher, Assaf Rudich. https://diabetes.diabetesjournals.org/content/early/2020/07/30/db19-1231.long

The SCFSkp2 ubiquitin ligase complex modulates TRAIL-R2-induced apoptosis by regulating FLIP(L) – Jamie Z. Roberts, Caitriona Holohan, Tamas Sessler, Jennifer Fox, Nyree Crawford, Joel S. Riley, Hajrah Khawaja, Joanna Majkut, Emma Evergren, Luke M. Humphreys, Jennifer Ferris, Catherine Higgins, Margarita Espona-Fiedler, Paul Moynagh, Simon S. McDade and Daniel B. Longley. https://www.nature.com/articles/s41418-020-0539-7

Tristetraprolin Posttranscriptionally Downregulates TRAIL Death Receptors – Won Hyeok Lee, Myung Woul Han, Song Hee Kim, Daseul Seong, Jae Hee An, Hyo Won Chang, Sang Yoon Kim, Seong Who Kim and Jong Cheol Lee. https://www.mdpi.com/2073-4409/9/8/1851

NORE1A directs apoptotic switch of TNF signaling through reciprocal modulation of ITCH-mediated destruction of TNFRI and BAX – Kyung-Phil Ko, Seong-In Jeong, Ji-Sun Lim, Kyung-Woo Lee, Min-Goo Lee and Sung-Gil Chi. https://www.nature.com/articles/s41388-020-01392-y

ALG2 Influences T cell apoptosis by regulating FASLG intracellular transportation – Wangsheng Ji; Yang Xin; Lianfei Zhang; Xinqi Liu. https://portlandpress.com/biochemj/article-abstract/477/16/3105/226005


Caspases and IAPs


14‐3‐3 protein binding blocks the dimerization interface of caspase‐2 – Dana Kalabova, Frantisek Filandr, Miroslava Alblova, Olivia Petrvalska, Matej Horvath, Petr Man, Tomas Obsil, Veronika Obsilova. https://febs.onlinelibrary.wiley.com/doi/abs/10.1111/febs.15215

BIRC2 Expression Impairs Anti-Cancer Immunity and Immunotherapy Efficacy [c-IAP1] – Debangshu Samanta, Tina Yi-Ting Huang, Rima Shah, Yongkang Yang, Fan Pan, Gregg L. Semenza. https://www.cell.com/cell-reports/fulltext/S2211-1247(20)31058-5


Necroptosis


Identification of MYC as an antinecroptotic protein that stifles RIPK1–RIPK3 complex formation – Daehyeon Seong, Manhyung Jeong, Jinho Seo, Ji-Yoon Lee, Chi Hyun Hwang, Ho-Chul Shin, Jeong Yoon Shin, Young Woo Nam, Jeong Yeon Jo, Haeseung Lee, Hye-Jung Kim, Hwa-Ryeon Kim, Ji Hoon Oh, Sang-Jun Ha, Seung Jun Kim, Jae-Seok Roe, Wankyu Kim, June-Won Cheong, Kwang-Hee Bae, Sang Chul Lee, Andrew Oberst, Peter Vandenabeele, Dong Hoon Shin, Eun-Woo Lee, and Jaewhan Song. https://www.pnas.org/content/117/33/19982.abstract?etoc

Catalytically inactive RIP1 and RIP3 deficiency protect against acute ischemic stroke by inhibiting necroptosis and neuroinflammation – Yue Zhang, Ming Li, Xiaoming Li, Haiwei Zhang, Lingxia Wang, Xiaoxia Wu, Haibing Zhang and Yan Luo. https://www.nature.com/articles/s41419-020-02770-w

Autocrine IL6-Mediated Activation of the STAT3–DNMT Axis Silences the TNFα–RIP1 Necroptosis Pathway to Sustain Survival and Accumulation of Myeloid-Derived Suppressor Cells – Alyssa D. Smith, Chunwan Lu, Daniela Payne, Amy V. Paschall, John D. Klement, Priscilla S. Redd, Mohammed L. Ibrahim, Dafeng Yang, Qimei Han, Zhuoqi Liu, Huidong Shi, Thomas J. Hartney, Asha Nayak-Kapoor and Kebin Liu. https://cancerres.aacrjournals.org/content/80/15/3145

Human cytomegalovirus protein pUL36: A dual cell death pathway inhibitor – Alice Fletcher-Etherington, Luis Nobre, Katie Nightingale, Robin Antrobus, Jenna Nichols, Andrew J. Davison, Richard J. Stanton, and Michael P. Weekes. https://www.pnas.org/content/117/31/18771.abstract?etoc

Necroptosis-based CRISPR knockout screen reveals Neuropilin-1 as a critical host factor for early stages of murine cytomegalovirus infection – Rebecca K. Lane, Hongyan Guo, Amanda D. Fisher, Jonathan Diep, Zhao Lai, Yidong Chen, Jason W. Upton, Jan Carette, Edward S. Mocarski, and William J. Kaiser. https://www.pnas.org/content/117/33/20109.abstract?etoc

Influenza-Induced Oxidative Stress Sensitizes Lung Cells to Bacterial-Toxin-Mediated Necroptosis – Norberto Gonzalez-Juarbe, Ashleigh N. Riegler, Alexander S. Jureka, Ryan P. Gilley, Jeffrey D. Brand, John E. Trombley, Ninecia R. Scott, Maryann P. Platt, Peter H. Dube, Chad M. Petit, Kevin S. Harrod, Carlos J. Orihuela. https://www.cell.com/cell-reports/fulltext/S2211-1247(20)31047-0

In vitro analysis reveals necroptotic signaling does not provoke DNA damage or HPRT mutations – Mark A. Miles and Christine J. Hawkins. https://www.nature.com/articles/s41419-020-02879-y


Ferroptosis


Ferroptosis occurs through an osmotic mechanism and propagates independently of cell rupture – Michelle Riegman, Liran Sagie, Chen Galed, Tom Levin, Noah Steinberg, Scott J. Dixon, Ulrich Wiesner, Michelle S. Bradbury, Philipp Niethammer, Assaf Zaritsky and Michael Overholtzer. https://www.nature.com/articles/s41556-020-0565-1?sf237346546=1

Lymph protects metastasizing melanoma cells from ferroptosis – Jessalyn M. Ubellacker, Alpaslan Tasdogan, Vijayashree Ramesh, Bo Shen, Evann C. Mitchell, Misty S. Martin-Sandoval, Zhimin Gu, Michael L. McCormick, Alison B. Durham, Douglas R. Spitz, Zhiyu Zhao, Thomas P. Mathews and Sean J. Morrison. https://www.nature.com/articles/s41586-020-2623-z

Dietary Lipids Induce Ferroptosis in Caenorhabditis elegans and Human Cancer Cells – Marcos A. Perez, Leslie Magtanong, Scott J. Dixon, Jennifer L. Watts. https://www.cell.com/developmental-cell/fulltext/S1534-5807(20)30498-6


Pyroptosis/mixed pathways


Impaired NLRP3 inflammasome activation/pyroptosis leads to robust inflammatory cell death via caspase-8/RIPK3 during coronavirus infection – Min Zheng, Evan Peter Williams, R. K. Subbarao Malireddi, Rajendra Karki, Balaji Banoth, Amanda Burton, Richard Webby, Rudragouda Channappanavar, Colleen Beth Jonsson and Thirumala-Devi Kanneganti. http://www.jbc.org/content/early/2020/08/06/jbc.RA120.015036.abstract

RIPK3 collaborates with GSDMD to drive tissue injury in lethal polymicrobial sepsis – Hui Chen, Yinshuang Li, Jianfeng Wu, Guoping Li, Xuan Tao, Kunmei Lai, Ying Yuan, Xiaohong Zhang, Zhenhuan Zou and Yanfang Xu. https://www.nature.com/articles/s41418-020-0524-1


Miscellanous


A fluorogenic cyclic peptide for imaging and quantification of drug-induced apoptosis – Nicole D. Barth, Ramon Subiros-Funosas, Lorena Mendive-Tapia, Rodger Duffin, Mario A. Shields, Jennifer A. Cartwright, Sónia Troeira Henriques, Jesus Sot, Felix M. Goñi, Rodolfo Lavilla, John A. Marwick, Sonja Vermeren, Adriano G. Rossi, Mikala Egeblad, Ian Dransfield and Marc Vendrell. https://www.nature.com/articles/s41467-020-17772-7

A splicing isoform of GPR56 mediates microglial synaptic refinement via phosphatidylserine binding – Tao Li, Brian Chiou, Casey K Gilman, Rong Luo, Tatsuhiro Koshi, Diankun Yu, Hayeon C Oak, Stefanie Giera, Erin Johnson‐Venkatesh, Allie K Muthukumar, Beth Stevens, Hisashi Umemori, Xianhua Piao. https://www.embopress.org/doi/abs/10.15252/embj.2019104136

Local externalization of phosphatidylserine mediates developmental synaptic pruning by microglia – Nicole Scott‐Hewitt, Fabio Perrucci, Raffaella Morini, Marco Erreni, Matthew Mahoney, Agata Witkowska, Alanna Carey, Elisa Faggiani, Lisa Theresia Schuetz, Sydney Mason, Matteo Tamborini, Matteo Bizzotto, Lorena Passoni, Fabia Filipello, Reinhard Jahn, Beth Stevens, Michela Matteoli. https://www.embopress.org/doi/full/10.15252/embj.2020105380

Dead cells release a ‘necrosignal’ that activates antibiotic survival pathways in bacterial swarms – Souvik Bhattacharyya, David M. Walker and Rasika M. Harshey. https://www.nature.com/articles/s41467-020-17709-0

Phosphorylation of cyclophilin D at serine 191 regulates mitochondrial permeability transition pore opening and cell death after ischemia-reperfusion – Stephen Hurst, Fabrice Gonnot, Maya Dia, Claire Crola Da Silva, Ludovic Gomez and Shey-Shing Sheu. https://www.nature.com/articles/s41419-020-02864-5


Reviews


Ferroptosis: Machinery and Regulation – Xin Chen, Jingbo Li, Rui Kang, Daniel J. Klionsky and Daolin Tang. https://www.tandfonline.com/doi/abs/10.1080/15548627.2020.1810918

Ubiquitination and deubiquitination of MCL1 in cancer: deciphering chemoresistance mechanisms and providing potential therapeutic options – Xiaowei Wu, Qingyu Luo and Zhihua Liu. https://www.nature.com/articles/s41419-020-02760-y

Autophagy as a modulator of cell death machinery – Masayuki Noguchi, Noriyuki Hirata, Tsutomu Tanaka, Futoshi Suizu, Hiroshi Nakajima and John A. Chiorini. https://www.nature.com/articles/s41419-020-2724-5


Comments / other


Igniting the spread of ferroptotic cell death – Andrew J. Davidson and Will Wood. https://www.nature.com/articles/s41556-020-0570-4

Please eat (only part) of me: synaptic phosphatidylserine cues microglia to feast : Two new studies identify how a common apoptotic cell flag is used to sculpt neural circuits – Graham Peet, F Chris Bennett, Mariko L Bennett. https://www.embopress.org/doi/abs/10.15252/embj.2020105924

In memoriam: Dr. Beth Levine (1960–2020)Jennifer Martinez. https://www.nature.com/articles/s41418-020-0595-z

On Sten Orrenius (1937–2020) – Boris Zhivotovsky and Pierluigi Nicotera. https://www.nature.com/articles/s41418-020-0594-0

Beth Levine (1960–2020) – Ramnik J. Xavier, Herbert W. Virgin. https://www.cell.com/molecular-cell/fulltext/S1097-2765(20)30514-1

Beth Levine 1960–2020 – Anna Katharina Simon and Noboru Mizushima. https://www.nature.com/articles/s41556-020-0555-3

Remembering Beth Levine – the autophagy pioneer and woman extraordinaire – Salwa Sebti, Congcong He, Sophie Pattingre, Alicia Meléndez, Ana Maria Cuervo, J. Marie Hardwick, Diane E. Griffin. https://febs.onlinelibrary.wiley.com/doi/full/10.1111/febs.15502

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