ApoList – October 2020


Bcl-2 family proteins


Mcl-1 and Bok transmembrane domains: Unexpected players in the modulation of apoptosis – Estefanía Lucendo, Mónica Sancho, Fabio Lolicato, Matti Javanainen, Waldemar Kulig, Diego Leiva, Gerard Duart, Vicente Andreu-Fernández, Ismael Mingarro, and Mar Orzáez. https://www.pnas.org/content/early/2020/10/21/2008885117.abstract

Ancient and conserved functional interplay between Bcl-2 family proteins in the mitochondrial pathway of apoptosis – Nikolay Popgeorgiev, Jaison D Sa, Lea Jabbour, Suresh Banjara, Trang Thi Minh Nguyen, Aida Akhavan-E-Sabet, Rudy Gadet, Nikola Ralchev, Stéphen Manon, Mark G. Hinds, Hans-Jürgen Osigus, Bernd Schierwater, Patrick O. Humbert, Ruth Rimokh, Germain Gillet, Marc Kvansakul. https://advances.sciencemag.org/content/6/40/eabc4149

Identification of BCL-XL as highly active survival factor and promising therapeutic target in colorectal cancer – Anna-Lena Scherr, Andreas Mock, Georg Gdynia, Nathalie Schmitt, Christoph E. Heilig, Felix Korell, Praveen Rhadakrishnan, Paula Hoffmeister, Klaus H. Metzeler, Klaus Schulze-Osthoff, Anna L. Illert, Melanie Boerries, Jörg Trojan, Oliver Waidmann, Johanna Falkenhorst, Jens Siveke, Philipp J. Jost, Michael Bitzer, Nisar P. Malek, Loredana Vecchione, Ivan Jelas, Benedikt Brors, Hanno Glimm, Albrecht Stenzinger, Svetlana P. Grekova, Tobias Gehrig, Henning Schulze-Bergkamen, Dirk Jäger, Peter Schirmacher, Mathias Heikenwalder, Benjamin Goeppert, Martin Schneider, Stefan Fröhling and Bruno C. Köhler. https://www.nature.com/articles/s41419-020-03092-7

BioID-based proteomic analysis of the Bid interactome identifies novel proteins involved in cell-cycle-dependent apoptotic priming – Robert Pedley, Louise E. King, Venkatesh Mallikarjun, Pengbo Wang, Joe Swift, Keith Brennan and Andrew P. Gilmore. https://www.nature.com/articles/s41419-020-03091-8

Leukemia Cell of Origin Influences Apoptotic Priming and Sensitivity to LSD1 Inhibition – Sheng F. Cai, S. Haihua Chu, Aaron D. Goldberg, Salma Parvin, Richard P. Koche, Jacob L. Glass, Eytan M. Stein, Martin S. Tallman, Filiz Sen, Christopher A. Famulare, Monica Cusan, Chun-Hao Huang, Chun-Wei Chen, Lihua Zou, Keith B. Cordner, Nicole L. DelGaudio, Vidushi Durani, Mitali Kini, Madison Rex, Helen S. Tian, Johannes Zuber, Timour Baslan, Scott W. Lowe, Hugh Y. Rienhoff Jr, Anthony Letai, Ross L. Levine and Scott A. Armstrong. https://cancerdiscovery.aacrjournals.org/content/10/10/1500

Methylation of HSP70 Orchestrates Its Binding to and Stabilization of BCL2 mRNA and Renders Pancreatic Cancer Cells Resistant to Therapeutics – Liang Wang, Zhiliang Jia, Dacheng Xie, Tiansuo Zhao, Zhi Tan, Shuxing Zhang, Fanyang Kong, Daoyan Wei and Keping Xie. https://cancerres.aacrjournals.org/content/80/20/4500

BH3 mimetics selectively eliminate chemotherapy-induced senescent cells and improve response in TP53 wild-type breast cancer – Ashkan Shahbandi, Sonia G. Rao, Ashlyn Y. Anderson, Wesley D. Frey, Joy O. Olayiwola, Nathan A. Ungerleider and James G. Jackson. https://www.nature.com/articles/s41418-020-0564-6


Death receptors


Human Cancers Express TRAILshort, a Dominant Negative TRAIL Splice Variant, Which Impairs Immune Effector Cell Killing of Tumor Cells – Fatma Aboulnasr, Ashton Krogman, Rondell P. Graham, Nathan W. Cummins, Anisha Misra, Enrique Garcia-Rivera, Jeff R. Anderson, Sekar Natesampillai, Nicole Kogan, Murali Aravamudan, Zilin Nie, Thomas D.Y. Chung, Richard Buick, Andrew L. Feldman, Rebecca L. King, Anne J. Novak, Stephen M. Ansell, Saad Kenderian and Andrew D. Badley. https://clincancerres.aacrjournals.org/content/26/21/5759

TRAIL receptor agonists convert the response of breast cancer cells to ONC201 from anti-proliferative to apoptotic – Marie D. Ralff, Aakash Jhaveri, Jocelyn E. Ray, Lanlan Zhou, Avital Lev, Kerry S. Campbell, David T. Dicker, Eric A. Ross,  and  Wafik S. El-Deiry. https://www.oncotarget.com/article/27773/text/

RALB GTPase: a critical regulator of DR5 expression and TRAIL sensitivity in KRAS mutant colorectal cancer – Hajrah Khawaja, Andrew Campbell, Jamie Z. Roberts, Arman Javadi, Paul O’Reilly, Darragh McArt, Wendy L. Allen, Joanna Majkut, Markus Rehm, Alberto Bardelli, Federica Di Nicolantonio, Christopher J. Scott, Richard Kennedy, Nicolas Vitale, Timothy Harrison, Owen J. Sansom, Daniel B. Longley, Emma Evergren and Sandra Van Schaeybroeck. https://www.nature.com/articles/s41419-020-03131-3

Stress-induced TRAILR2 expression overcomes TRAIL resistance in cancer cell spheroids – Daniela Stöhr, Jens O. Schmid, Tobias B. Beigl, Alexandra Mack, Daniela S. Maichl, Kai Cao, Beate Budai, Gavin Fullstone, Roland E. Kontermann, Thomas E. Mürdter, Stephen W. G. Tait, Cathrin Hagenlocher, Nadine Pollak, Peter Scheurich and Markus Rehm. https://www.nature.com/articles/s41418-020-0559-3


Caspases and IAPs


Integration of innate immune signalling by caspase-8 cleavage of N4BP1 – Alexander D. Gitlin, Klaus Heger, Alexander F. Schubert, Rohit Reja, Donghong Yan, Victoria C. Pham, Eric Suto, Juan Zhang, Youngsu C. Kwon, Emily C. Freund, Jing Kang, Anna Pham, Roger Caothien, Natasha Bacarro, Trent Hinkle, Min Xu, Brent S. McKenzie, Benjamin Haley, Wyne P. Lee, Jennie R. Lill, Merone Roose-Girma, Monika Dohse, Joshua D. Webster, Kim Newton and Vishva M. Dixit. https://www.nature.com/articles/s41586-020-2796-5

A Non-canonical PDK1-RSK Signal Diminishes Pro-caspase-8-Mediated Necroptosis Blockade – Zhang-Hua Yang, Xiao-Nan Wu, Peng He, Xuekun Wang, Jianfeng Wu, Tingting Ai, Chuan-Qi Zhong, Xiurong Wu, Yu Cong, Rongfeng Zhu, Hongda Li, Zhi-Yu Cai, Wei Mo, Jiahuai Han. https://www.cell.com/molecular-cell/fulltext/S1097-2765(20)30612-2

The Inhibitor of Apoptosis Protein Livin Confers Resistance to Fas-Mediated Immune Cytotoxicity in Refractory Lymphoma – Eiji Sugihara, Norisato Hashimoto, Satoru Osuka, Takatsune Shimizu, Sayaka Ueno, Shogo Okazaki, Tomonori Yaguchi, Yutaka Kawakami, Kenjiro Kosaki, Taka-Aki Sato, Shinichiro Okamoto and Hideyuki Saya. https://cancerres.aacrjournals.org/content/80/20/4439


Necroptosis


Beclin 1 functions as a negative modulator of MLKL oligomerisation by integrating into the necrosome complex – Jinho Seo, Daehyeon Seong, Young Woo Nam, Chi Hyun Hwang, Seung Ri Lee, Choong-Sil Lee, Young Jin, Han-Woong Lee, Doo-Byoung Oh, Peter Vandenabeele and Jaewhan Song. https://www.nature.com/articles/s41418-020-0561-9

RIPK1 gene variants associate with obesity in humans and can be therapeutically silenced to reduce obesity in mice – Denuja Karunakaran, Adam W. Turner, Anne-Claire Duchez, Sebastien Soubeyrand, Adil Rasheed, David Smyth, David P. Cook, Majid Nikpay, Joshua W. Kandiah, Calvin Pan, Michele Geoffrion, Richard Lee, Ludovic Boytard, Hailey Wyatt, My-Anh Nguyen, Paulina Lau, Markku Laakso, Bhama Ramkhelawon, Marcus Alvarez, Kirsi H. Pietiläinen, Päivi Pajukanta, Barbara C. Vanderhyden, Peter Liu, Scott B. Berger, Peter J. Gough, John Bertin, Mary-Ellen Harper, Aldons J. Lusis, Ruth McPherson and Katey J. Rayner. https://www.nature.com/articles/s42255-020-00279-2

ZBP1 promotes fungi-induced inflammasome activation and pyroptosis, apoptosis, and necroptosis (PANoptosis) – Balaji Banoth, Shraddha Tuladhar, Rajendra Karki, Bhesh Raj Sharma, Benoit Briard, Sannula Kesavardhana, Amanda Burton and Thirumala-Devi Kanneganti. http://www.jbc.org/content/early/2020/10/27/jbc.RA120.015924.abstract


Pyroptosis


PD-L1-mediated gasdermin C expression switches apoptosis to pyroptosis in cancer cells and facilitates tumour necrosis – Junwei Hou, Rongce Zhao, Weiya Xia, Chiung-Wen Chang, Yun You, Jung-Mao Hsu, Lei Nie, Yeh Chen, Yu-Chuan Wang, Chunxiao Liu, Wei-Jan Wang, Yun Wu, Baozhen Ke, Jennifer L. Hsu, Kebin Huang, Zu Ye, Yi Yang, Xianghou Xia, Yintao Li, Chia-Wei Li, Bin Shao, John A. Tainer and Mien-Chie Hung. https://www.nature.com/articles/s41556-020-0575-z

CARD8 inflammasome activation triggers pyroptosis in human T cells – Andreas Linder, Stefan Bauernfried, Yiming Cheng, Manuel Albanese, Christophe Jung, Oliver T Keppler, Veit Hornung. https://www.embopress.org/doi/full/10.15252/embj.2020105071


Ferroptosis


Excessive phospholipid peroxidation distinguishes ferroptosis from other cell death modes including pyroptosis – Bartosz Wiernicki, Hanne Dubois, Yulia Y. Tyurina, Behrouz Hassannia, Hülya Bayir, Valerian E. Kagan, Peter Vandenabeele, Andy Wullaert and Tom Vanden Berghe. https://www.nature.com/articles/s41419-020-03118-0

Neutrophil-induced ferroptosis promotes tumor necrosis in glioblastoma progression – Patricia P. Yee, Yiju Wei, Soo-Yeon Kim, Tong Lu, Stephen Y. Chih, Cynthia Lawson, Miaolu Tang, Zhijun Liu, Benjamin Anderson, Krishnamoorthy Thamburaj, Megan M. Young, Dawit G. Aregawi, Michael J. Glantz, Brad E. Zacharia, Charles S. Specht, Hong-Gang Wang and Wei Li. https://www.nature.com/articles/s41467-020-19193-y

Dynasore Blocks Ferroptosis through Combined Modulation of Iron Uptake and Inhibition of Mitochondrial Respiration – Laura Prieto Clemente, Malena Rabenau, Stephan Tang, Josefina Stanka, Eileen Cors, Jenny Stroh, Carsten Culmsee  and Silvia von Karstedt. https://www.mdpi.com/2073-4409/9/10/2259

BAX-dependent mitochondrial pathway mediates the crosstalk between ferroptosis and apoptosis – Young-Sun Lee, Kalishwaralal Kalimuthu, Yong Seok Park, Xu Luo, M. Haroon A. Choudry, David L. Bartlett and Yong J. Lee. https://link.springer.com/article/10.1007/s10495-020-01627-z

Relieving ferroptosis may partially reverse neurodegeneration of the auditory cortex – Xi Chen, Dan Li, Hai‐Ying Sun, Wen‐Wen Wang, Han Wu, Wen Kong, Wei‐Jia Kong. https://febs.onlinelibrary.wiley.com/doi/abs/10.1111/febs.15266


Miscellanous


Nox4 regulates InsP3 receptor‐dependent Ca2+ release into mitochondria to promote cell survival – Matteo Beretta, Celio XC Santos, Chris Molenaar, Anne D Hafstad, Chris CJ Miller, Aram Revazian, Kai Betteridge, Katrin Schröder, Katrin Streckfuß‐Bömeke, James H Doroshow, Roland A Fleck, Tsung‐Ping Su, Vsevolod V Belousov, Maddy Parsons, Ajay M Shah. https://www.embopress.org/doi/full/10.15252/embj.2019103530

Mammalian lipid droplets are innate immune hubs integrating cell metabolism and host defense – Marta Bosch, Miguel Sánchez-Álvarez, Alba Fajardo, Ronan Kapetanovic, Bernhard Steiner, Filipe Dutra, Luciana Moreira, Juan Antonio López, Rocío Campo, Montserrat Marí, Frederic Morales-Paytuví, Olivia Tort, Albert Gubern, Rachel M. Templin, James E. B. Curson, Nick Martel, Cristina Català, Francisco Lozano, Francesc Tebar, Carlos Enrich, Jesús Vázquez, Miguel A. Del Pozo, Matthew J. Sweet, Patricia T. Bozza, Steven P. Gross, Robert G. Parton, Albert Pol. https://science.sciencemag.org/content/370/6514/eaay8085

NETosis Occurs Independently of Neutrophil Serine Proteases – Paulina Kasperkiewicz, Anne Hempel, Tomasz Janiszewski, Sonia Kolt, Scott J Snipas, Marcin Drag and Guy S Salvesen. http://www.jbc.org/content/early/2020/10/15/jbc.RA120.015682.abstract

Cytokine regulation of apoptosis-induced apoptosis and apoptosis-induced cell proliferation in vascular smooth muscle cells – Dimitra Aravani, Kirsty Foote, Nichola Figg, Alison Finigan, Anna Uryga, Murray Clarke, Martin Bennett. https://link.springer.com/article/10.1007/s10495-020-01622-4


Reviews


Emerging connectivity of programmed cell death pathways and its physiological implications – Sammy Bedoui, Marco J. Herold and Andreas Strasser. https://www.nature.com/articles/s41580-020-0270-8

Inflammasomes and Cell Death: Common Pathways in Microparticle Diseases – Maryam Rashidi, Ian P. Wicks, James E. Vince. https://www.cell.com/trends/molecular-medicine/fulltext/S1471-4914(20)30156-8

FLIP(L): the pseudo‐caspase – Peter Smyth, Tamas Sessler, Christopher J. Scott, Daniel B. Longley. https://febs.onlinelibrary.wiley.com/doi/full/10.1111/febs.15260

Emerging aspects in the regulation of ferroptosis – Helene Nehring, Svenja Meierjohann, Jose Pedro Friedmann Angeli. https://portlandpress.com/biochemsoctrans/article-abstract/doi/10.1042/BST20200523/226668/

Ferroptosis – Daolin Tang, Guido Kroemer. https://www.cell.com/current-biology/fulltext/S0960-9822(20)31438-X

Cardiolipin in Immune Signaling and Cell Death – Malvina Pizzuto, Pablo Pelegrin. https://www.cell.com/trends/cell-biology/fulltext/S0962-8924(20)30173-2

Cell Death in the Tumor Microenvironment: Implications for Cancer Immunotherapy – Varsha Gadiyar, Kevin C. Lahey, David Calianese, Connor Devoe, Dhriti Mehta, Kristy Bono, Samuel Desind, Viralkumar Davra and Raymond B. Birge. https://www.mdpi.com/2073-4409/9/10/2207

The role of death domain proteins in host response upon SARS-CoV-2 infection: modulation of programmed cell death and translational applications – Nikita V. Ivanisenko, Kamil Seyrek, Nikolay A. Kolchanov, Vladimir A. Ivanisenko and Inna N. Lavrik. https://www.nature.com/articles/s41420-020-00331-w

Interconnections among major forms of regulated cell death – Chaoyi Wu, Liting Zhou, Haibo Yuan, Shuyan Wu. https://link.springer.com/article/10.1007/s10495-020-01632-2


Comments


TRAIL and Cancer Immunotherapy: Take a Walk on the Short Side – Diego de Miguel and Julián Pardo. https://clincancerres.aacrjournals.org/content/26/21/5546

Caspase-8 protein cuts a brake on immune defences – Igor E. Brodsky. https://www.nature.com/articles/d41586-020-02994-y

PD-L1 controls cancer pyroptosis – María Teresa Blasco and Roger R. Gomis. https://www.nature.com/articles/s41556-020-00582-w

Immiscible immunity – Douglas R. Green. https://science-sciencemag-org.sire.ub.edu/content/370/6514/294.full

Apoptotic mitochondria prime anti-tumour immunity – Kate McArthur and Benjamin T. Kile. https://www.nature.com/articles/s41420-020-00335-6

MINORITY MOMP: A TOXIC, SLOW DEMISE – Yuan Xu, Deborah R. Surman,  and  R. Taylor Ripley. https://impactjournals.us9.list-manage.com/track/click?u=133779c099e52b6fa9d4dec2e&id=d5d624ce33&e=923b339f12

Letter to the editor: iron, apoptosis, and ferroptosis – Andrew J. Ghio. https://link.springer.com /article/10.1007/s10495-020-01628-y

A checkpoint for pyroptosis – Wei Wong. https://stke.sciencemag.org/content/13/655/eabf4018

The IAP Antagonist Debio 1143 Enhances Chemoradiotherapy in HNSCC. https://cancerdiscovery.aacrjournals.org/content/10/10/1437.1

Ferroptosis Is Inhibited in Lymph, Promoting Metastasis of Melanoma. https://cancerdiscovery.aacrjournals.org/content/10/11/1621.1

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