Dear all,
Please allow me to advertise this service in case you want to do your personalized ApoList, or a weekly list of interesting articles on any topic. Biomed News (www.biomed.news) proposes you new records in PubMed every week, ranked by machine learning. You select your favorite items, they are sent to you via email, and you can then disseminate the weekly list yourself. Other users can browse it at http://biomed.news/reports
Regards,
Cris
Bcl-2 family proteins
STING-dependent paracriny shapes apoptotic priming of breast tumors in response to anti-mitotic treatment – Steven Lohard, Nathalie Bourgeois, Laurent Maillet, Fabien Gautier, Aurélie Fétiveau, Hamza Lasla, Frédérique Nguyen, Céline Vuillier, Alison Dumont, Agnès Moreau-Aubry, Morgane Frapin, Laurent David, Delphine Loussouarn, Olivier Kerdraon, Mario Campone, Pascal Jézéquel, Philippe P. Juin and Sophie Barillé-Nion. https://www.nature.com/articles/s41467-019-13689-y
Allosteric Regulation of BH3 Proteins in Bcl-xL Complexes Enables Switch-like Activation of Bax – Christian Bogner, Justin Kale, Justin Pogmore, Xiaoke Chi, Aisha Shamas-Din, Cécile Fradin, Brian Leber, David W. Andrews. https://www.cell.com/molecular-cell/fulltext/S1097-2765(19)30955-4
A selective BCL-XL PROTAC degrader achieves safe and potent antitumor activity – Sajid Khan, Xuan Zhang, Dongwen Lv, Qi Zhang, Yonghan He, Peiyi Zhang, Xingui Liu, Dinesh Thummuri, Yaxia Yuan, Janet S. Wiegand, Jing Pei, Weizhou Zhang, Abhisheak Sharma, Christopher R. McCurdy, Vinitha M. Kuruvilla, Natalia Baran, Adolfo A. Ferrando, Yong-mi Kim, Anna Rogojina, Peter J. Houghton, Guangcun Huang, Robert Hromas, Marina Konopleva, Guangrong Zheng and Daohong Zhou. https://www.nature.com/articles/s41591-019-0668-z
Overexpression of Antiapoptotic MCL-1 Predicts Worse Overall Survival of Patients With Non-small Cell Lung Cancer – Nakano T, Go T, Nakashima N, Liu D, Yokomise H. http://ar.iiarjournals.org/content/40/2/1007.abstract
Potent efficacy of MCL-1 inhibitor-based therapies in preclinical models of mantle cell lymphoma – Michael A. Dengler, Charis E. Teh, Rachel Thijssen, Lahiru Gangoda, Ping Lan, Marco J. Herold, Daniel H. Gray, Gemma L. Kelly, Andrew W. Roberts and Jerry M. Adams. https://www.nature.com/articles/s41388-019-1122-x
Aurora A Kinase Inhibition Destabilizes PAX3-FOXO1 and MYCN and Synergizes with Navitoclax to Induce Rhabdomyosarcoma Cell Death – Johannes Ommer, Joanna L. Selfe, Marco Wachtel, Eleanor M. O’Brien, Dominik Laubscher, Michaela Roemmele, Stephanie Kasper, Olivier Delattre, Didier Surdez, Gemma Petts, Anna Kelsey, Janet Shipley and Beat W. Schäfer. https://cancerres.aacrjournals.org/content/80/4/832
MCL-1 antagonism enhances the anti-invasive effects of dasatinib in pancreatic adenocarcinoma – Lesley Castillo, Adelaide I. J. Young, Amanda Mawson, Pia Schafranek, Angela M. Steinmann, Danielle Nessem, Ashleigh Parkin, Amber Johns, Angela Chou, Andrew M. K. Law, Morghan C. Lucas, Kendelle J. Murphy, Niantao Deng, David Gallego-Ortega, Catherine E. Caldon, Australian Pancreatic Cancer Genome Initiative (APGI), Paul Timpson, Marina Pajic, Christopher J. Ormandy and Samantha R. Oakes. https://www.nature.com/articles/s41388-019-1091-0
Dynamic PGAM5 multimers dephosphorylate BCL-xL or FUNDC1 to regulate mitochondrial and cellular fate – Kaili Ma, Zhi Zhang, Rui Chang, Hongcheng Cheng, Chenglong Mu, Tian Zhao, Linbo Chen, Chuanmei Zhang, Qian Luo, Jialing Lin, Yushan Zhu and Quan Chen. https://www.nature.com/articles/s41418-019-0396-4
Death receptors
Long and short isoforms of c-FLIP act as control checkpoints of DED filament assembly – Laura K. Hillert, Nikita V. Ivanisenko, Johannes Espe, Corinna König, Vladimir A. Ivanisenko, Thilo Kähne and Inna N. Lavrik. https://www.nature.com/articles/s41388-019-1100-3
The parkin-coregulated gene product PACRG promotes TNF signaling by stabilizing LUBAC – Jens Meschede , Maria Šadić, Nikolas Furthmann, Tim Miedema, Dominik A. Sehr, A. Kathrin Müller-Rischart, Verian Bader, Lena A. Berlemann, Anna Pilsl, Anita Schlierf, Katalin Barkovits, Barbara Kachholz, Katrin Rittinger, Fumiyo Ikeda, Katrin Marcus, Liliana Schaefer, Jörg Tatzelt, Konstanze F. Winklhofer. https://stke.sciencemag.org/content/13/617/eaav1256
Cell death induced by the ER stressor thapsigargin involves death receptor 5, a non-autophagic function of MAP1LC3B, and distinct contributions from unfolded protein response components – Lindner P, Christensen SB, Nissen P, Møller JV, Engedal N. https://biosignaling.biomedcentral.com/articles/10.1186/s12964-019-0499-z
OTULIN Prevents Liver Inflammation and Hepatocellular Carcinoma by Inhibiting FADD- and RIPK1 Kinase-Mediated Hepatocyte Apoptosis – Lien Verboom, Arne Martens, Dario Priem, Esther Hoste, Mozes Sze, Hanna Vikkula, Lisette Van Hove, Sofie Voet, Jana Roels, Jonathan Maelfait, Laura Bongiovanni, Alain de Bruin, Charlotte L. Scott, Yvan Saeys, Manolis Pasparakis, Mathieu J.M. Bertrand, Geert van Loo. https://www.cell.com/cell-reports/fulltext/S2211-1247(20)30037-1
Caspases
E2F-Family Members Engage the PIDDosome to Limit Hepatocyte Ploidy in Liver Development and Regeneration – Valentina C. Sladky, Katja Knapp, Claudia Soratroi, Julia Heppke, Felix Eichin, Lourdes Rocamora-Reverte, Tamas G. Szabo, Laura Bongiovanni, Bart Westendorp, Eva Moreno, Elsbeth A. van Liere, Bjorn Bakker, Diana C.J. Spierings, René Wardenaar, David Pereyra, Patrick Starlinger, Simon Schultze, Michael Trauner, Tatjana Stojakovic, Hubert Scharnagl, Luca L. Fava, Floris Foijer, Alain de Bruin, Andreas Villunger. https://www.cell.com/developmental-cell/fulltext/S1534-5807(19)31039-1
Opposing effects of polysulfides and thioredoxin on apoptosis through caspase persulfidation – Ilana Braunstein, Rotem Engelman, Ofer Yitzhaki, Tamar Ziv, Erwan Galardon and Moran Benhar. http://www.jbc.org/content/early/2020/02/10/jbc.RA119.012357.abstract
An AMPK–caspase-6 axis controls liver damage in nonalcoholic steatohepatitis – Peng Zhao, Xiaoli Sun, Cynthia Chaggan, Zhongji Liao, Kai in Wong, Feng He, Seema Singh, Rohit Loomba, Michael Karin, Joseph L. Witztum, Alan R. Saltiel. https://science.sciencemag.org/content/367/6478/652
Necroptosis and RIP kinases
RIP1 kinase activity is critical for skin inflammation but not for viral propagation – Joshua D. Webster Youngsu C. Kwon Summer Park Hua Zhang Nick Corr Nina Ljumanovic Adeyemi O. Adedeji Eugene Varfolomeev Tatiana Goncharov Jessica Preston Sara F. Santagostino Snahel Patel Min Xu Jonathan Maher Brent S. McKenzie Domagoj Vucic. https://jlb.onlinelibrary.wiley.com/doi/full/10.1002/JLB.3MA1219-398R
Phenotypic high-throughput screening platform identifies novel chemotypes for necroptosis inhibition – Hugo Brito, Vanda Marques, Marta B. Afonso, Dean G. Brown, Ulf Börjesson, Nidhal Selmi, David M. Smith, Ieuan O. Roberts, Martina Fitzek, Natália Aniceto, Rita C. Guedes, Rui Moreira and Cecília M. P. Rodrigues. https://www.nature.com/articles/s41420-020-0240-0
Ferroptosis
Energy-stress-mediated AMPK activation inhibits ferroptosis – Hyemin Lee, Fereshteh Zandkarimi, Yilei Zhang, Jitendra Kumar Meena, Jongchan Kim, Li Zhuang, Siddhartha Tyagi, Li Ma, Thomas F. Westbrook, Gregory R. Steinberg, Daisuke Nakada, Brent R. Stockwell and Boyi Gan. https://www.nature.com/articles/s41556-020-0461-8
Miscellanous
Cell Death in Cells Overlying Lateral Root Primordia Facilitates Organ Growth in Arabidopsis – Sacha Escamez, Domenique André, Bernadette Sztojka, Benjamin Bollhöner, Hardy Hall, Béatrice Berthet, Ute Voß, Amnon Lers, Alexis Maizel, Magnus Andersson, Malcolm Bennett, Hannele Tuominen. https://www.cell.com/current-biology/fulltext/S0960-9822(19)31580-5
Coordinated changes in cell membrane and cytoplasm during maturation of apoptotic bleb – Kana Aoki, Shinsuke Satoi, Shota Harada, Seiichi Uchida, Yoh Iwasa, and Junichi Ikenouchi. https://www.molbiolcell.org/doi/10.1091/mbc.E19-12-0691?ai=25zg&ui=2oy6&af=T
Control of cell death/survival balance by the MET dependence receptor – Leslie Duplaquet, Catherine Leroy, Audrey Vinchent, Sonia Paget, Jonathan Lefebvre, Fabien Vanden Abeele, Steve Lancel, Florence Giffard, Réjane Paumelle, Gabriel Bidaux, Laurent Heliot, Laurent Poulain, Alessandro Furlan, David Tulasne. https://elifesciences.org/articles/50041
Reviews
RIPK1 Kinase-Dependent Death: A Symphony of Phosphorylation Events – Tom Delanghe, Yves Dondelinger, Mathieu J.M. Bertrand. https://www.cell.com/trends/cell-biology/fulltext/S0962-8924(19)30223-5
SMAC mimetics and RIPK inhibitors as therapeutics for chronic inflammatory diseases – Simone Jensen, Jakob Benedict Seidelin, Eric Charles LaCasse, and Ole Haagen Nielsen. https://stke.sciencemag.org/content/13/619/eaax8295
Comments
Mechanisms for Ca2+-dependent permeability transition in mitochondria – Paolo Bernardi. https://www.pnas.org/content/117/6/2743?etoc=
Reply to Bernardi: The mitochondrial permeability transition pore and the ATP synthase – John E. Walker, Joe Carroll, and Jiuya He. https://www.pnas.org/content/117/6/2745
Loss of ferritin in developing wing cells: Apoptosis and ferroptosis coincide – Anna Karen Hernández-Gallardo, Fanis Missirlis. https://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1008503
The PROTAC DT2216 Targets Cancer by Promoting BCL-XL Degradation – https://cancerdiscovery.aacrjournals.org/content/10/2/174.1
Apoptosis and cell death 