ApoList – January 2020


Immunogenicity of cell death


Quantitative and Dynamic Catalogs of Proteins Released during Apoptotic and Necroptotic Cell Death – Maria C. Tanzer, Annika Frauenstein, Che A. Stafford, Kshiti Phulphagar, Matthias Mann, Felix Meissner. https://www.cell.com/cell-reports/fulltext/S2211-1247(19)31744-9

Immunodominant AH1 Antigen-Deficient Necroptotic, but Not Apoptotic, Murine Cancer Cells Induce Antitumor Protection – Tania Løve Aaes, Hanne Verschuere, Agnieszka Kaczmarek, Liesbeth Heyndrickx, Bartosz Wiernicki, Iris Delrue, Bram De Craene, Joachim Taminau, Tinneke Delvaeye, Mathieu J. M. Bertrand, Wim Declercq, Geert Berx, Dmitri V. Krysko, Sandy Adjemian and Peter Vandenabeele. https://www.jimmunol.org/content/early/2020/01/02/jimmunol.1900072

Immune Sensing of Cell Death through Recognition of Histone Sequences by C-Type Lectin-Receptor-2d Causes Inflammation and Tissue Injury – Jiann-Jyh Lai, Freidrich M. Cruz, Kenneth L. Rock. https://www.cell.com/immunity/fulltext/S1074-7613(19)30494-7

Characterization of virus-mediated immunogenic cancer cell death and the consequences for oncolytic virus-based immunotherapy of cancer – Jing Ma, Mohanraj Ramachandran, Chuan Jin, Clara Quijano-Rubio, Miika Martikainen, Di Yu and Magnus Essand. https://www.nature.com/articles/s41419-020-2236-3


Death receptors


Misfolded proteins bind and activate death receptor 5 to induce apoptosis during unresolved endoplasmic reticulum stress – Mable Lam, Scot A Marsters, Avi Ashkenazi, Peter Walter. https://elifesciences.org/articles/52291

Heterogeneous responses to low level death receptor activation are explained by random molecular assembly of the Caspase-8 activation platform – Matveeva A, Fichtner M, McAllister K, McCann C, Sturrock M, Longley DB, Prehn JHM. https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1007374

Single-molecule imaging reveals the oligomeric state of functional TNFα-induced plasma membrane TNFR1 clusters in cells – Christos Karathanasis, Juliane Medler, Franziska Fricke, Sonja Smith, Sebastian Malkusch, Darius Widera, Simone Fulda, Harald Wajant, Sjoerd J. L. van Wijk, Ivan Dikic and Mike Heilemann. https://stke.sciencemag.org/content/13/614/eaax5647


Bcl-2 family proteins


Mitochondrial residence of the apoptosis inducer BAX is more important than BAX oligomerization in promoting membrane permeabilization – Tomomi Kuwana, Louise E King, Katia Cosentino, Julian Suess, Ana J. García-Sáez, Andrew P. Gilmore and Donald D Newmeyer. http://www.jbc.org/content/early/2020/01/03/jbc.RA119.011635.abstract

Dynein light chain binding determines complex formation and posttranslational stability of the Bcl-2 family members Bmf and Bim – Prafull Kumar Singh, Aristomenis Roukounakis, Arnim Weber, Kushal Kumar Das, Benedicte Sohm, Andreas Villunger, Ana J. Garcia-Saez and Georg Häcker. https://www.nature.com/articles/s41418-019-0365-y

Loss of Bcl-G, a Bcl-2 family member, augments the development of inflammation-associated colorectal cancer – Paul M. Nguyen, Laura F. Dagley, Adele Preaudet, Nga Lam, Maybelline Giam, Ka Yee Fung, Kaheina Aizel, Gemma van Duijneveldt, Chin Wee Tan, Yumiko Hirokawa, Hon Yan K. Yip, Christopher G. Love, Ashleigh R. Poh, Akshay D’ Cruz, Charlotte Burstroem, Rebecca Feltham, Suad M. Abdirahman, Kristy Meiselbach, Ronnie Ren Jie Low, Michelle Palmieri, Matthias Ernst, Andrew I. Webb, Tony Burgess, Oliver M. Sieber, Philippe Bouillet and Tracy L. Putoczki. https://www.nature.com/articles/s41418-019-0383-9

Human BCL-G regulates secretion of inflammatory chemokines but is dispensable for induction of apoptosis by IFN-γ and TNF-α in intestinal epithelial cells – Jerzy A. Woznicki, Peter Flood, Milan Bustamante-Garrido, Panagiota Stamou, Gerry Moloney, Aine Fanning, Syed Akbar Zulquernain, Jane McCarthy, Fergus Shanahan, Silvia Melgar and Ken Nally. https://www.nature.com/articles/s41419-020-2263-0

Characterization of a novel human BFL-1-specific monoclonal antibody – Lahiru Gangoda, Charis E. Teh, Michael A. Dengler, Sarah A. Best, Clare E. Weeden, Lin Tai, Erinna F. Lee, Walter D. Fairlie, Kate D. Sutherland, Leonard C. Harrison, Daniel H. Gray, Andreas Strasser and Marco J. Herold. https://www.nature.com/articles/s41418-019-0454-y

Bile acid-induced “Minority MOMP” promotes esophageal carcinogenesis while maintaining apoptotic resistance via Mcl-1 – Yuan Xu, Deborah R. Surman, Laurence Diggs, Sichuan Xi, Shaojian Gao, Devikala Gurusamy, Kaitlin McLoughlin, Justin Drake, Paul Feingold, Kate Brown, Danny Wangsa, Darawalee Wangsa, Xi Zhang, Thomas Ried, Jeremy L. Davis, Jonathan Hernandez, Chuong D. Hoang, Rhonda F. Souza, David S. Schrump and R. Taylor Ripley. https://www.nature.com/articles/s41388-019-1029-6

The carboxyl-terminal sequence of bim enables bax activation and killing of unprimed cells – Xiaoke Chi, Dang Nguyen, James M Pemberton, Elizabeth J Oesterlund, Qian Liu, Hetal Brahmbhatt, Zhi Zhang, Jialing Lin, Brian Leber, David W Andrews. https://elifesciences.org/articles/44525

Type 1 Innate Lymphoid Cells Protect Mice from Acute Liver Injury via Interferon-γ Secretion for Upregulating Bcl-xL Expression in Hepatocytes – Tsukasa Nabekura, Luke Riggan, Andrew D. Hildreth, Timothy E. O’Sullivan, Akira Shibuya. https://www.cell.com/immunity/fulltext/S1074-7613(19)30462-5


Caspases


Exploring the prime site in caspases as a novel chemical strategy for understanding the mechanisms of cell death: a proof of concept study on necroptosis in cancer cells – Katarzyna Groborz, Monica L. Gonzalez Ramirez, Scott J. Snipas, Guy S. Salvesen, Marcin Drąg and Marcin Poręba. https://www.nature.com/articles/s41418-019-0364-z


Necroptosis / RIP kinases


CK1α, CK1δ, and CK1ε are necrosome components which phosphorylate serine 227 of human RIPK3 to activate necroptosis – Sarah Hanna-Addams, Shuzhen Liu, Hua Liu, She Chen and Zhigao Wang. https://www.pnas.org/content/117/4/1962.abstract?etoc

Casein kinase-1γ1 and 3 stimulate tumor necrosis factor-induced necroptosis through RIPK3 – Song-Yi Lee, Hyunjoo Kim, Cathena Meiling Li, Jaemin Kang, Ayaz Najafov, Muhah Jung, Soosung Kang, Shaomeng Wang, Junying Yuan and Yong-Keun Jung. https://www.nature.com/articles/s41419-019-2146-4

Constitutive Interferon Attenuates RIPK1/3-Mediated Cytokine Translation – Hayley I. Muendlein, Joseph Sarhan, Beiyun C. Liu, Wilson M. Connolly, Stephen A. Schworer, Irina Smirnova, Amy Y. Tang, Vladimir Ilyukha, Jodie Pietruska, Soroush Tahmasebi, Nahum Sonenberg, Alexei Degterev, Alexander Poltorak. https://www.cell.com/cell-reports/fulltext/S2211-1247(19)31730-9

Resolvin D1 promotes the targeting and clearance of necroptotic cells – Brennan D. Gerlach, Michael Marinello, Justin Heinz, Nicholas Rymut, Brian E. Sansbury, Colin O. Riley, Sudeshna Sadhu, Zeinab Hosseini, Yoko Kojima, Dale D. Tang, Nicholas J. Leeper, Matthew Spite, Margarida Barroso, Katey J. Rayner and Gabrielle Fredman. https://www.nature.com/articles/s41418-019-0370-1


Ferroptosis


ATF3 promotes erastin-induced ferroptosis by suppressing system Xc – Liyuan Wang, Yichen Liu, Tingting Du, Heng Yang, Lei Lei, Mengqi Guo, Han-Fei Ding, Junran Zhang, Hongbo Wang, Xiaoguang Chen and Chunhong Yan. https://www.nature.com/articles/s41418-019-0380-z


Miscellanous


Programmed cell death along the midline axis patterns ipsilaterality in gastrulation – Lisandro Maya-Ramos, Takashi Mikawa. https://science.sciencemag.org/content/367/6474/197

Nuclear degradation dynamics in a nonapoptotic programmed cell death – Alla Yalonetskaya, Albert A. Mondragon, Zackary J. Hintze, Susan Holmes and Kimberly McCall. https://www.nature.com/articles/s41418-019-0382-x


Reviews


Mitochondria as multifaceted regulators of cell death – Florian J. Bock and Stephen W. G. Tait. https://www.nature.com/articles/s41580-019-0173-8

Beyond inflammasomes: emerging function of gasdermins during apoptosis and NETosis – Kaiwen W Chen, Benjamin Demarco, Petr Broz. https://www.embopress.org/doi/abs/10.15252/embj.2019103397

Immunological impact of cell death signaling driven by radiation on the tumor microenvironment – Maria Esperanza Rodriguez-Ruiz, Ilio Vitale, Kevin J. Harrington, Ignacio Melero and Lorenzo Galluzzi. https://www.nature.com/articles/s41590-019-0561-4

Saga of Mcl-1: regulation from transcription to degradation – Viacheslav V. Senichkin, Alena Y. Streletskaia, Anna S. Gorbunova, Boris Zhivotovsky and Gelina S. Kopeina. https://www.nature.com/articles/s41418-019-0486-3


Comments


A matter of life and death for caspase 8 – Joseph Willson. https://www.nature.com/articles/s41580-019-0201-8

Clec2d Joins the Cell Death Sensor Ranks – Carlos del Fresno, David Sancho. https://www.cell.com/immunity/fulltext/S1074-7613(19)30534-5

 

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