ApoList – March 2020

Research is important. Keep strong everyone

 


Death receptors


TRAIL Receptors Serve as Stress-Associated Molecular Patterns to Promote ER-Stress-Induced Inflammation – Graeme P. Sullivan, Hazel O’Connor, Conor M. Henry, Pavel Davidovich, Danielle M. Clancy, Matthew L. Albert, Sean P. Cullen, Seamus J. Martin. https://www.cell.com/developmental-cell/fulltext/S1534-5807(20)30063-0

A20 Promotes Ripoptosome Formation and TNF-Induced Apoptosis via cIAPs Regulation and NIK Stabilization in Keratinocytes – Maria Feoktistova, Roman Makarov, Sihem Brenji, Anne T. Schneider, Guido J. Hooiveld, Tom Luedde, Martin Leverkus, Amir S. Yazdi and Diana Panayotova-Dimitrova. https://www.mdpi.com/2073-4409/9/2/351

Targeting the Extrinsic Pathway of Hepatocyte Apoptosis Promotes Clearance of Plasmodium Liver Infection – Gregor Ebert, Sash Lopaticki, Matthew T. O’Neill, Ryan W.J. Steel, Marcel Doerflinger, Pravin Rajasekaran, Annie S.P. Yang, Sara Erickson, Lisa Ioannidis, Philip Arandjelovic, Liana Mackiewicz, Cody Allison, John Silke, Marc Pellegrini, Justin A. Boddey. https://www.cell.com/cell-reports/fulltext/S2211-1247(20)30346-6


Caspases and cFLIP


Cancer Cells Employ Nuclear Caspase-8 to Overcome the p53-Dependent G2/M Checkpoint through Cleavage of USP28 – Ines Müller, Elwira Strozyk, Sebastian Schindler, Stefan Beissert, Htoo Zarni Oo, Thomas Sauter, Philippe Lucarelli, Sebastian Raeth, Angelika Hausser, Nader Al Nakouzi, Ladan Fazli, Martin E. Gleave, He Liu, Hans-Uwe Simon, Henning Walczak, Douglas R. Green, Jiri Bartek, Mads Daugaard, Dagmar Kulms. https://www.cell.com/molecular-cell/fulltext/S1097-2765(19)30953-0

Cross-regulation between LUBAC and caspase-1 modulates cell death and inflammation – Todd Douglas and Maya Saleh. http://www.jbc.org/content/early/2020/03/02/jbc.RA119.011622.abstract


Gastermins and pyroptosis


Gasdermin E suppresses tumour growth by activating anti-tumour immunity – Zhibin Zhang, Ying Zhang, Shiyu Xia, Qing Kong, Shunying Li, Xing Liu, Caroline Junqueira, Karla F. Meza-Sosa, Temy Mo Yin Mok, James Ansara, Satyaki Sengupta, Yandan Yao, Hao Wu and Judy Lieberman. https://www.nature.com/articles/s41586-020-2071-9

cFLIPL protects macrophages from LPS-induced pyroptosis via inhibition of complex II formation – Hayley I. Muendlein, David Jetton, Wilson M. Connolly, Keith P. Eidell, Zoie Magri, Irina Smirnova, Alexander Poltorak. https://science.sciencemag.org/content/367/6484/1379

A bioorthogonal system reveals antitumour immune function of pyroptosis – Qinyang Wang, Yupeng Wang, Jingjin Ding, Chunhong Wang, Xuehan Zhou, Wenqing Gao, Huanwei Huang, Feng Shao and Zhibo Liu. https://www.nature.com/articles/s41586-020-2079-1

Structural Mechanism for GSDMD Targeting by Autoprocessed Caspases in Pyroptosis – Kun Wang, Qi Sun, Xiu Zhong, Mengxue Zeng, Huan Zeng, Xuyan Shi, Zilin Li, Yupeng Wang, Qiang Zhao, Feng Shao, Jingjin Ding. https://www.cell.com/cell/fulltext/S0092-8674(20)30146-X

Mitochondrial GSDMD Pores DAMPen Pyroptosis – Katherine C. Barnett, Jenny P.-Y. Ting. https://www.cell.com/immunity/fulltext/S1074-7613(20)30083-2

mtDNA Activates cGAS Signaling and Suppresses the YAP-Mediated Endothçelial Cell Proliferation Program to Promote Inflammatory Injury – Long Shuang Huang, Zhigang Hong, Wei Wu, Shiqin Xiong, Ming Zhong, Xiaopei Gao, Jalees Rehman, Asrar B. Malik. https://www.cell.com/immunity/fulltext/S1074-7613(20)30083-2

A bioorthogonal system reveals antitumour immune function of pyroptosis – Qinyang Wang, Yupeng Wang, Jingjin Ding, Chunhong Wang, Xuehan Zhou, Wenqing Gao, Huanwei Huang, Feng Shao and Zhibo Liu. https://www.nature.com/articles/s41586-020-2079-1


Bcl-2 family proteins


A small-molecule allosteric inhibitor of BAX protects against doxorubicin-induced cardiomyopathy – Dulguun Amgalan, Thomas P. Garner, Ryan Pekson, Xiaotong F. Jia, Mounica Yanamandala, Victor Paulino, Felix G. Liang, J. Jose Corbalan, Jaehoon Lee, Yun Chen, George S. Karagiannis, Luis Rivera Sanchez, Huizhi Liang, Swathi-Rao Narayanagari, Kelly Mitchell, Andrea Lopez, Victoria Margulets, Marco Scarlata, Gaetano Santulli, Aarti Asnani, Randall T. Peterson, Rachel B. Hazan, John S. Condeelis, Maja H. Oktay, Ulrich Steidl, Lorrie A. Kirshenbaum, Evripidis Gavathiotis and Richard N. Kitsis. https://www.nature.com/articles/s43018-020-0039-1

Site-Dependent Cysteine Lipidation Potentiates the Activation of Proapoptotic BAX – Daniel T. Cohen, Thomas E. Wales, Matthew W. McHenry, John R. Engen, Loren D. Walensky. https://www.cell.com/cell-reports/fulltext/S2211-1247(20)30225-4

Low expression of pro-apoptotic proteins Bax, Bak and Smac indicates prolonged progression-free survival in chemotherapy-treated metastatic melanoma – Cristiano Guttà, Arman Rahman, Claudia Aura, Peter Dynoodt, Emilie M. Charles, Elodie Hirschenhahn, Jesuchristopher Joseph, Jasper Wouters, Ciaran de Chaumont, Mairin Rafferty, Madhuri Warren, Joost J. van den Oord, William M. Gallagher and Markus Rehm. https://www.nature.com/articles/s41419-020-2309-3

SFTSV Infection Induces BAK/BAX-Dependent Mitochondrial DNA Release to Trigger NLRP3 Inflammasome Activation – Shufen Li, Hao Li, Yu-Lan Zhang, Qi-Lin Xin, Zhen-Qiong Guan, Xi Chen, Xiao-Ai Zhang, Xiao-Kun Li, Geng-Fu Xiao, Pierre-Yves Lozach, Jun Cui, Wei Liu, Lei-Ke Zhang, Ke Peng. https://www.cell.com/cell-reports/fulltext/S2211-1247(20)30286-2

Combined reduction in the expression of MCL-1 and BCL-2 reduces organismal size in mice – Francine Ke, Graeme I. Lancaster, Stephanie Grabow, Andrew J. Murphy and Andreas Strasser. https://www.nature.com/articles/s41419-020-2376-5

MCL1 is Required for Maintenance of Intestinal Homeostasis and Prevention of Carcinogenesis in Mice – Marc E. Healy, Yannick Boege, Michael C. Hodder, Friederike Böhm, Mohsen Malehmir, Anna-Lena Scherr, Jasna Jetzer, Lap Kwan Chan, Rossella Parrotta, Kurt Jacob, Laure-Alix Clerbaux, Susanne Kreutzer, Andrew Campbell, Ella Gilchrist, Kathryn Gilroy, Ann-Katrin Rodewal , Hanna Honcharova-Biletska, Roman Schimmer, Karelia Vélez, Simone Büeler, Patrizia Cammareri , Gabriela Kalna, Anna S. Wenning, Kathy D. McCoy, Mercedes Gomez de Agüero, Henning Schulze-Bergkamen, Christoph Klose, Kristian Unger, Andrew J. Macpherson , Andreas E. Moor, Bruno Köhler, Owen J. Sanso, Mathias Heikenwalder, Achim Weber. https://www.gastrojournal.org/article/S0016-5085(20)30338-3/fulltext

HUWE1 controls MCL1 stability to unleash AMBRA1-induced mitophagyFlavie Strappazzon, Anthea Di Rita, Angelo Peschiaroli, Pier Paolo Leoncini, Franco Locatelli, Gerry Melino and Francesco Cecconi. https://www.nature.com/articles/s41418-019-0404-8

MCL1 binding to the reverse BH3 motif of P18INK4C couples cell survival to cell proliferation – Robert H. Whitaker and William J. Placzek. https://www.nature.com/articles/s41419-020-2351-1

MCL1 inhibition is effective against a subset of small-cell lung cancer with high MCL1 and low BCL-XL expression – Yuto Yasuda, Hiroaki Ozasa, Young Hak Kim, Masatoshi Yamazoe, Hitomi Ajimizu, Tomoko Yamamoto Funazo, Takashi Nomizo, Takahiro Tsuji, Hironori Yoshida, Yuichi Sakamori, Naoki Nakajima, Toshi Menju, Akihiko Yoshizawa, Hiroshi Date and Toyohiro Hirai. https://www.nature.com/articles/s41419-020-2379-2

Conformational Switching in Bcl-xL: Enabling Non-Canonic Inhibition of Apoptosis Involves Multiple Intermediates and Lipid Interactions – Victor Vasquez-Montes, Alexander Kyrychenko, Mauricio Vargas-Uribe, Mykola V. Rodnin and Alexey S. Ladokhin. https://www.mdpi.com/2073-4409/9/3/539

Electron transport chain activity is a predictor and target for venetoclax sensitivity in multiple myeloma – Richa Bajpai, Aditi Sharma, Abhinav Achreja, Claudia L. Edgar, Changyong Wei, Arusha A. Siddiqa, Vikas A. Gupta, Shannon M. Matulis, Samuel K. McBrayer, Anjali Mittal, Manali Rupji, Benjamin G. Barwick, Sagar Lonial, Ajay K. Nooka, Lawrence H. Boise, Deepak Nagrath and Mala Shanmugam. https://www.nature.com/articles/s41467-020-15051-z


Necroptosis


Sequential activation of necroptosis and apoptosis cooperates to mediate vascular and neural pathology in stroke – Masanori Gomi Naito, Daichao Xu, Palak Amin, Jinwoo Lee, Huibing Wang, Wanjin Li, Michelle Kelliher, Manolis Pasparakis, and Junying Yuan. https://www.pnas.org/content/117/9/4959.abstract?etoc

Z-nucleic-acid sensing triggers ZBP1-dependent necroptosis and inflammation – Huipeng Jiao, Laurens Wachsmuth, Snehlata Kumari, Robin Schwarzer, Juan Lin, Remzi Onur Eren, Amanda Fisher, Rebecca Lane, George R. Young, George Kassiotis, William J. Kaiser and Manolis Pasparakis. https://www.nature.com/articles/s41586-020-2129-8

Gut stem cell necroptosis by genome instability triggers bowel inflammation – Ruicong Wang, Hongda Li, Jianfeng Wu, Zhi-Yu Cai, Baizhou Li, Hengxiao Ni, Xingfeng Qiu, Hui Chen, Wei Liu, Zhang-Hua Yang, Min Liu, Jin Hu, Yaoji Liang, Ping Lan, Jiahuai Han and Wei Mo. https://www.nature.com/articles/s41586-020-2127-x

Inhibition of keratinocyte necroptosis mediated by RIPK1/RIPK3/MLKL provides a protective effect against psoriatic inflammation – Xiaoru Duan, Xinxin Liu, Nian Liu, Yuqiong Huang, Zilin Jin, Song Zhang, Zhangyin Ming and Hongxiang Chen. https://www.nature.com/articles/s41419-020-2328-0

Necroptosis-blocking compound NBC1 targets heat shock protein 70 to inhibit MLKL polymerization and necroptosis – Andrea N. Johnston, Yuyong Ma, Hua Liu, Shuzhen Liu, Sarah Hanna-Addams, She Chen, Chuo Chen and Zhigao Wang. https://www.pnas.org/content/117/12/6521.abstract?etoc

Influenza Virus Z-RNAs Induce ZBP1-Mediated Necroptosis – Ting Zhang, Chaoran Yin, David F. Boyd, Giovanni Quarato, Justin P. Ingram, Maria Shubina, Katherine B. Ragan, Takumi Ishizuka, Jeremy Chase Crawford, Bart Tummers, Diego A. Rodriguez, Jia Xue, Suraj Peri, William J. Kaiser, Carolina B. López, Yan Xu, Jason W. Upton, Paul G. Thomas, Douglas R. Green, Siddharth Balachandran. https://www.cell.com/cell/fulltext/S0092-8674(20)30227-0

The necroptosis machinery mediates axonal degeneration in a model of Parkinson diseaseMaritza Oñate, Alejandra Catenaccio, Natalia Salvadores, Cristian Saquel, Alexis Martinez, Ines Moreno-Gonzalez, Nazaret Gamez, Paulina Soto, Claudio Soto, Claudio Hetz and Felipe A. Court. https://www.nature.com/articles/s41418-019-0408-4


Ferroptosis


Transferrin Receptor Is a Specific Ferroptosis Marker – Huizhong Feng, Kenji Schorpp, Jenny Jin, Carrie E. Yozwiak, Benjamin G. Hoffstrom, Aubrianna M. Decker, Presha Rajbhandari, Michael E. Stokes, Hannah G. Bender, Joleen M. Csuka, Pavan S. Upadhyayula, Peter Canoll, Koji Uchida, Rajesh K. Soni, Kamyar Hadian, Brent R. Stockwell. https://www.cell.com/cell-reports/fulltext/S2211-1247(20)30210-2

Mitochondrial DNA stress triggers autophagy-dependent ferroptotic death – Li C, Zhang Y, Liu J, Kang R, Klionsky DJ, Tang D. https://www.tandfonline.com/doi/full/10.1080/15548627.2020.1739447

Caspase-1 interdomain linker cleavage is required for pyroptosis – Daniel P Ball, Cornelius Y Taabazuing, Andrew R Griswold, Elizabeth L Orth, Sahana D Rao, Ilana B Kotliar, Lauren E Vostal, Darren C Johnson and Daniel A Bachovchin. https://www.life-science-alliance.org/content/3/3/e202000664.abstract


Efferocytosis and cell-cell effects


Metabolites released from apoptotic cells act as tissue messengers – Christopher B. Medina, Parul Mehrotra, Sanja Arandjelovic, Justin S. A. Perry, Yizhan Guo, Sho Morioka, Brady Barron, Scott F. Walk, Bart Ghesquière, Alexander S. Krupnick, Ulrike Lorenz and Kodi S. Ravichandran. https://www.nature.com/articles/s41586-020-2121-3

Macrophage Metabolism of Apoptotic Cell-Derived Arginine Promotes Continual Efferocytosis and Resolution of Injury – Arif Yurdagul Jr., Manikandan Subramanian, Xiaobo Wang, Scott B. Crown, Olga R. Ilkayeva, Lancia Darville, Gopi K. Kolluru, Christina C. Rymond, Brennan D. Gerlach, Ze Zheng, George Kuriakose, Christopher G. Kevil, John M. Koomen, John L. Cleveland, Deborah M. Muoio, Ira Tabas. https://www.sciencedirect.com/science/article/abs/pii/S1550413120300012


Miscellanous


In vivo detection of programmed cell death during mouse heart development – Kristel Martínez-Lagunas, Yoshifumi Yamaguchi, Cora Becker, Caroline Geisen, Marco C. DeRuiter, Masayuki Miura, Bernd K. Fleischmann and Michael Hesse. https://www.nature.com/articles/s41418-019-0426-2


Reviews


Classification and Nomenclature of Metacaspases and Paracaspases: No More Confusion with Caspases – Elena A. Minina, Jens Staal, Vanina E. Alvarez, John A. Berges, Ilana Berman-Frank, Rudi Beyaert, Kay D. Bidle, Frédéric Bornancin, Magali Casanova, Juan J. Cazzulo, Chang Jae Choi, Nuria S. Coll, Vishva M. Dixit, Marko Dolinar, Nicolas Fasel, Christiane Funk, Patrick Gallois, Kris Gevaert, Emilio Gutierrez-Beltran, Stephan Hailfinger, Marina Klemenčič, Eugene V. Koonin, Daniel Krappmann, Anna Linusson, Maurício F.M. Machado, Frank Madeo, Lynn A. Megeney, Panagiotis N. Moschou, Jeremy C. Mottram, Thomas Nyström, Heinz D. Osiewacz, Christopher M. Overall, Kailash C. Pandey, Jürgen Ruland, Guy S. Salvesen, Yigong Shi, Andrei Smertenko, Simon Stael, Jerry Ståhlberg, María Fernanda Suárez, Margot Thome, Hannele Tuominen, Frank Van Breusegem, Renier A.L. van der Hoorn, Assaf Vardi, Boris Zhivotovsky, Eric Lam, Peter V. Bozhkov. https://www.cell.com/molecular-cell/fulltext/S1097-2765(19)30950-5

Investigating Nonapoptotic Cell Death Using Chemical Biology Approaches – David A. Armenta, Scott J. Dixon. https://www.cell.com/cell-chemical-biology/fulltext/S2451-9456(20)30079-9

Ferroptosis: past, present and future – Jie Li, Feng Cao, He-liang Yin, Zi-jian Huang, Zhi-tao Lin, Ning Mao, Bei Sun and Gang Wang. https://www.nature.com/articles/s41419-020-2298-2

Restoring Apoptosis with BH3 Mimetics in Mature B-Cell Malignancies – Maxime Jullien, Patricia Gomez-Bougie, David Chiron and Cyrille Touzeau. https://www.mdpi.com/2073-4409/9/3/717


Comments


Ghostly metabolic messages from dying cells – Douglas R. Green. https://www.nature.com/articles/d41586-020-00641-0

ER Stress Leaves an Inflammatory TRAIL – Alba Roca Portoles, Stephen W.G. Tait. https://www.cell.com/developmental-cell/fulltext/S1534-5807(20)30188-X

Appetite for Arginine: Metabolic Control of Macrophage Hunger – Daniel J. Puleston, Erika L. Pearce. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(20)30064-4

TAMing efferocytosis to fight tumors – Christopher B. Rodell. https://stm.sciencemag.org/content/12/533/eabb0795

Destroying tumors with pyroptosis – John F. Foley. https://stke.sciencemag.org/content/13/624/eabb8244

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