Bcl-2 family proteins
The carboxyl-terminal sequence of PUMA binds to both anti-apoptotic proteins and membranes – James M Pemberton, Dang Nguyen, Elizabeth J Osterlund, Wiebke Schormann, Justin P Pogmore, Nehad Hirmiz, Brian Leber, David W Andrews. https://elifesciences.org/articles/88329
Lymphoma cells lacking pro-apoptotic BAX are highly resistant to BH3-mimetics targeting pro-survival MCL-1 but retain sensitivity to conventional DNA-damaging drugs – Sarah T. Diepstraten, Savannah Young, John E. La Marca, Zilu Wang, Ruth M. Kluck, Andreas Strasser and Gemma L. Kelly. https://www.nature.com/articles/s41418-023-01117-0
Death receptors
XIAP deletion sensitizes mice to TNF-induced and RIP1-mediated death – Axel Witt, Tatiana Goncharov, Yujung Michelle Lee, Matthias Kist, Monika Dohse, Jeff Eastham, Debra Dugger, Kim Newton, Joshua D. Webster and Domagoj Vucic. https://www.nature.com/articles/s41419-023-05793-1
Therapeutic efficacy of a MMAE-based anti-DR5 drug conjugate Oba01 in preclinical models of pancreatic cancer – Chao Zheng, Dongdong Zhou, Weisong Li, Yanhui Duan, Minwen Xu, Jie Liu, Jingpei Cheng, Youban Xiao, Han Xiao, Tao Gan, Jianmin Liang, Dexian Zheng, Liefeng Wang and Shuyong Zhang. https://www.nature.com/articles/s41419-023-05820-1
Caspases
Caspase-8 is required for HSV-1-induced apoptosis and promotes effective viral particle release via autophagy inhibition – Francesca Marino-Merlo, Anusha Klett, Emanuela Papaianni, Selene Francesca Anna Drago, Beatrice Macchi, María Gabriela Rincón, Federica Andreola, Annalucia Serafino, Sandro Grelli, Antonio Mastino and Christoph Borner. https://www.nature.com/articles/s41418-022-01084-y
Necroptosis
RIPK3 promoter hypermethylation in hepatocytes protects from bile acid-induced inflammation and necroptosis – Jessica Hoff, Ling Xiong, Tobias Kammann, Sophie Neugebauer, Julia M. Micheel, Nikolaus Gaßler, Michael Bauer and Adrian T. Press. https://www.nature.com/articles/s41419-023-05794-0
MLKL deficiency protects against low-grade, sterile inflammation in aged mice – Emma C. Tovey Crutchfield, Sarah E. Garnish, Jessica Day, Holly Anderton, Shene Chiou, Anne Hempel, Cathrine Hall, Komal M. Patel, Pradnya Gangatirkar, Katherine R. Martin, Connie S. N. Li Wai Suen, Alexandra L. Garnham, Andrew J. Kueh, Ian P. Wicks, John Silke, Ueli Nachbur, Andre L. Samson, James M. Murphy and Joanne M. Hildebrand. https://www.nature.com/articles/s41418-023-01121-4
Pyroptosis
Distinct GSDMB protein isoforms and protease cleavage processes differentially control pyroptotic cell death and mitochondrial damage in cancer cells – Sara S. Oltra, Sara Colomo, Laura Sin, María Pérez-López, Sara Lázaro, Angela Molina-Crespo, Kyoung-Han Choi, David Ros-Pardo, Lidia Martínez, Saleta Morales, Cristina González-Paramos, Alba Orantes, Mario Soriano, Alberto Hernández, Ana Lluch, Federico Rojo, Joan Albanell, Paulino Gómez-Puertas, Jae-Kyun Ko, David Sarrió and Gema Moreno-Bueno. https://www.nature.com/articles/s41418-023-01143-y
Alternative splicing of GSDMB modulates killer lymphocyte-triggered pyroptosis – Qing Kong, Shiyu Xia, Xingxin Pan, Kaixiong Ye, Zhouyihan Li, Haoyan Li, Xiaoqiang Tang, Nidhi Sahni, S. Stephen Yi, Xing Liu, Hao Wu, Michael B. Elowitz, Judy Lieberman, Zhibin Zhang. https://www.science.org/doi/10.1126/sciimmunol.adg3196
USP48 Stabilizes Gasdermin E to Promote Pyroptosis in Cancer – Yidan Ren, Maoxiao Feng, Xiaodong Hao, Xiaoyan Liu, Juan Li, Peilong Li, Jie Gao, Qiuchen Qi, Lutao Du, Chuanxin Wang, Qin Wang, Yunshan Wang. https://aacrjournals.org/cancerres/article-abstract/83/7/1074/718998
Ferroptosis
Lipid peroxidation increases membrane tension, Piezo1 gating, and cation permeability to execute ferroptosis – Yusuke Hirata, Ruiqi Cai, Allen Volchuk, Benjamin E. Steinberg, Yoshiro Saito, Atsushi Matsuzawa, Sergio Grinstein, Spencer A. Freeman. https://www.cell.com/current-biology/fulltext/S0960-9822(23)00200-2
Efferocytosis, entosis etc
An Unexpected Role of Neutrophils in Clearing Apoptotic Hepatocytes In Vivo – Luyang Cao, Lixiang Ma, Juan Zhao, Xiangyu Wang, Xinzou Fan, Wei Li, Yawen Qi, Yingkui Tang, Jieya Liu, Shengxian PengLi YangLiangxue ZhouLi Li, Xiaobo Hu, Yuan Ji, Yingyong Hou, Yi Zhao, Xianming Zhang, Youyang Zhao, Yong Zhao, Yuquan Wei, Asrar B. Malik, Hexige Saiyin, J ingsong Xu. https://elifesciences.org/reviewed-preprints/86591
Miscellanous
Quantifying requirements for mitochondrial apoptosis in CAR T killing of cancer cells – Alexandra L. Pourzia, Michael L. Olson, Stefanie R. Bailey, Angela C. Boroughs, Aditi Aryal, Jeremy Ryan, Marcela V. Maus and Anthony Letai. https://www.nature.com/articles/s41419-023-05727-x
Live-cell imaging and mathematical analysis of the “community effect” in apoptosis – Diane Coursier, David Coulette, Hélène Leman, Emmanuel Grenier, Gabriel Ichim. https://link.springer.com/article/10.1007/s10495-022-01783-4
Reviews
Apoptosis: a Janus bifrons in T-cell immunotherapy – Yong Gu Lee, Nicholas Yang, Inkook Chun, Patrizia Porazzi, Alberto Carturan, Luca Paruzzo, Christopher Tor Sauter, Puneeth Guruprasad, Raymone Pajarillo and Marco Ruella. https://jitc.bmj.com/content/11/4/e005967
Cell death, therapeutics, and the immune response in cancer – Kay Hänggi, Brian Ruffell. https://www.cell.com/trends/cancer/fulltext/S2405-8033(23)00021-3
To not love thy neighbor: mechanisms of cell competition in stem cells and beyond – Marianna Yusupova and Yaron Fuchs. https://www.nature.com/articles/s41418-023-01114-3
Ferroptosis: A flexible constellation of related biochemical mechanisms – Scott J. Dixon, Derek A. Pratt. https://www.cell.com/molecular-cell/fulltext/S1097-2765(23)00162-4
Caspases help to spread the message via extracellular vesicles – Claire Hill, Elizabeth R. Dellar, Luis Alberto Baena-Lopez. https://febs.onlinelibrary.wiley.com/doi/full/10.1111/febs.16418
Comments
LC3-independent autophagy is vital to prevent TNF cytotoxicity – Dario Priem, Jon Huyghe and Mathieu JM Bertrand. https://www.tandfonline.com/doi/abs/10.1080/15548627.2023.2197760
Ferroptosis: Under pressure! – Adam Wahida, Marcus Conrad. https://www.cell.com/current-biology/fulltext/S0960-9822(23)00297-X
Lysosomal lipid peroxidation mediates immunogenic cell death – Pravin Phadatare and Jayanta Debnath. https://www.jci.org/articles/view/169240
Sayonara to some evolutionary puzzles in the Bcl‐2 family – Kristin White. https://www.embopress.org/doi/full/10.15252/embj.2023113980
The road to death: Caspases, cleavage, and pores – Vishva M. Dixit. https://www.science.org/doi/full/10.1126/sciadv.adi2011
Editor Profile: Ana García Sáez – https://febs.onlinelibrary.wiley.com/doi/full/10.1111/febs.16732
Apoptosis and cell death 