ApoList – March 2023

Pore-forming proteins

Norovirus MLKL-like protein initiates cell death to induce viral egress – Guoxun Wang, Di Zhang, Robert C. Orchard, Dustin C. Hancks and Tiffany A. Reese. https://www.nature.com/articles/s41586-023-05851-w

Structural basis for GSDMB pore formation and its targeting by IpaH7.8 – Chengliang Wang, Sonia Shivcharan, Tian Tian, Skylar Wright, Danyang Ma, JengYih Chang, Kunpeng Li, Kangkang Song, Chen Xu, Vijay A. Rathinam and Jianbin Ruan. https://www.nature.com/articles/s41586-023-05832-z

Structural mechanisms for regulation of GSDMB pore-forming activity – Xiu Zhong, Huan Zeng, Zhiwei Zhou, Ya Su, Hang Cheng, Yanjie Hou, Yang She, Na Feng, Jia Wang, Feng Shao and Jingjin Ding. https://www.nature.com/articles/s41586-023-05872-5

More pore-forming proteins – Bcl-2 family

Visualization of BOK pores independent of BAX and BAK reveals a similar mechanism with differing regulation – Raed Shalaby, Arzoo Diwan, Hector Flores-Romero, Vanessa Hertlein and Ana J. Garcia-Saez. https://www.nature.com/articles/s41418-022-01078-w

Mitochondrial E3 ubiquitin ligase MARCHF5 controls BAK apoptotic activity independently of BH3-only proteins – Allan Shuai Huang, Hui San Chin, Boris Reljic, Tirta M. Djajawi, Iris K. L. Tan, Jia-Nan Gong, David A. Stroud, David C. S. Huang, Mark F. van Delft and Grant Dewson. https://www.nature.com/articles/s41418-022-01067-z

A BAK subdomain that binds mitochondrial lipids selectively and releases cytochrome C – Haiming Dai, Kevin L. Peterson, Karen S. Flatten, X. Wei Meng, Annapoorna Venkatachalam, Cristina Correia, Marina Ramirez-Alvarado, Yuan-Ping Pang and Scott H. Kaufmann. https://www.nature.com/articles/s41418-022-01083-z

Synthetic lethality of drug-induced polyploidy and BCL-2 inhibition in lymphoma – Ana Portelinha, Mariana da Silva Ferreira, Tatiana Erazo, Man Jiang, Zahra Asgari, Elisa de Stanchina, Anas Younes and Hans-Guido Wendel. https://www.nature.com/articles/s41467-023-37216-2

Post-MOMP events

Executioner caspases restrict mitochondrial RNA-driven Type I IFN induction during chemotherapy-induced apoptosis – Shane T. Killarney, Rachel Washart, Ryan S. Soderquist, Jacob P. Hoj, Jamie Lebhar, Kevin H. Lin and Kris C. Wood. https://www.nature.com/articles/s41467-023-37146-z

Apoptotic cell fragments locally activate tingible body macrophages in the germinal center – Abigail K. Grootveld, Wunna Kyaw, Veera Panova, Angelica W.Y. Lau, Emily Ashwin, Guillaume Seuzaret, Rama Dhenni, Nayan Deger Bhattacharyya, Weng Hua Khoo, Maté Biro, Tanmay Mitra, Michael Meyer-Hermann, Patrick Bertolino, Masato Tanaka, David A. Hume, Peter I. Croucher, Robert Brink, Akira Nguyen, Oliver Bannard, Tri Giang Phan. https://www.cell.com/cell/fulltext/S0092-8674(23)00106-X

F-actin-rich territories coordinate apoptosome assembly and caspase activation during DNA damage-induced intrinsic apoptosis – Virginia L King, and Kenneth G Campellone. https://www.molbiolcell.org/doi/abs/10.1091/mbc.E22-04-0119

Death receptors

Breast tumors interfere with endothelial TRAIL at the premetastatic niche to promote cancer cell seeding – Carla Riera-Domingo, Eduarda Leite-Gomes, Iris Charatsidou, Peihua Zhao, Giovanna Carrá, Federica Cappellesso, Larissa Mourao, Maxim De Schepper, Dana Liu, Jens Serneels, Mohamad-Gabriel Alameh, Vladimir V. Shuvaev, Tatjana Geukens, Edoardo Isnaldi, Hans Prenen, Drew Weissman, Vladimir R. Muzykantov, Stefaan Soenen, Christine Desmedt, Colinda L. G. J. Scheele, Anna Sablina, Mario Di Matteo, Rosa Martín-Pérez, Massimiliano Mazzone. https://www.science.org/doi/full/10.1126/sciadv.add5028

Inhibition of multiple CDKs potentiates colon cancer chemotherapy via p73-mediated DR5 induction – Jingshan Tong, Xiao Tan, Suisui Hao, Kaylee Ermine, Xinyan Lu, Zhaojin Liu, Anupma Jha, Jian Yu and Lin Zhang. https://www.nature.com/articles/s41388-023-02598-6


Blebs promote cell survival by assembling oncogenic signalling hubs – Andrew D. Weems, Erik S. Welf, Meghan K. Driscoll, Felix Y. Zhou, Hanieh Mazloom-Farsibaf, Bo-Jui Chang, Vasanth S. Murali, Gabriel M. Gihana, Byron G. Weiss, Joseph Chi, Divya Rajendran, Kevin M. Dean, Reto Fiolka and Gaudenz Danuser. https://www.nature.com/articles/s41586-023-05758-6

Actin cytoskeleton vulnerability to disulfide stress mediates disulfidptosis – Xiaoguang Liu, Litong Nie, Yilei Zhang, Yuelong Yan, Chao Wang, Medina Colic, Kellen Olszewski, Amber Horbath, Xiong Chen, Guang Lei, Chao Mao, Shiqi Wu, Li Zhuang, Masha V. Poyurovsky, M. James You, Traver Hart, Daniel D. Billadeau, Junjie Chen and Boyi Gan. https://www.nature.com/articles/s41556-023-01091-2

SMAC mimetics inhibit human T cell proliferation and fail to augment type 1 cytokine responses – Ashley M Burton, Brittany R Ligman, Claire A Kearney, Susan E Murray. https://www.sciencedirect.com/science/article/abs/pii/S0008874923000138?via%3Dihub


Mitochondrial pores at the crossroad between cell death and inflammatory signaling – Hector Flores-Romero, Shashank Dadsena, Ana J. García-Sáez. https://www.cell.com/molecular-cell/fulltext/S1097-2765(23)00124-7


A massive machine regulates cell death – Peter D. Mace and Catherine L. Day. https://www.science.org/doi/abs/10.1126/science.adg9605

Deadly actin collapse by disulfidptosis – Laura M. Machesky. https://www.nature.com/articles/s41556-023-01100-4


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