Month: April 2019

cris

ApoList – April 2019

If wish to subscribe please visit the following link – http://eepurl.com/cvmBlv

Mitochondrial pathway

Gasdermin pores permeabilize mitochondria to augment caspase-3 activation during apoptosis and inflammasome activation – Corey Rogers, Dan A. Erkes, Alexandria Nardone, Andrew E. Aplin, Teresa Fernandes-Alnemri and Emad S. Alnemri. https://www.nature.com/articles/s41467-019-09397-2

Intrinsic apoptosis shapes the tumor spectrum linked to inactivation of the deubiquitinase BAP1 – Meng He, Mira S. Chaurushiya, Joshua D. Webster, Sarah Kummerfeld, Rohit Reja, Subhra Chaudhuri, Ying-Jiun Chen, Zora Modrusan, Benjamin Haley, Debra L. Dugger, Jeffrey Eastham-Anderson, Shari Lau, Anwesha Dey, Roger Caothien, Merone Roose-Girma, Kim Newton, Vishva M. Dixit. https://science.sciencemag.org/content/364/6437/283.abstract

Cytochrome c Deficiency Confers Apoptosome and Mitochondrial Dysfunction in African-American Men with Prostate Cancer – Rahul Kumar, Tariq A. Bhat, Elise M. Walsh, Ajay K. Chaudhary, Jordan O’Malley, Johng S. Rhim, Jianmin Wang, Carl D. Morrison, Kristopher Attwood, Wiam Bshara, James L. Mohler, Neelu Yadav and Dhyan Chandra. http://cancerres.aacrjournals.org/content/79/7/1353

Ceramides bind VDAC2 to trigger mitochondrial apoptosis – Shashank Dadsena, Svenja Bockelmann, John G. M. Mina, Dina G. Hassan, Sergei Korneev, Guilherme Razzera, Helene Jahn, Patrick Niekamp, Dagmar Müller, Markus Schneider, Fikadu G. Tafesse, Siewert J. Marrink, Manuel N. Melo and Joost C. M. Holthuis. https://www.nature.com/articles/s41467-019-09654-4

Mitochondrial pathway – Bcl-2 family proteins

BAX Activation: Mutations Near Its Proposed Non-canonical BH3 Binding Site Reveal Allosteric Changes Controlling Mitochondrial Association – Michael A. Dengler, Adeline Y. Robin, Leonie Gibson, Mark X. Li, Jarrod J. Sandow, Sweta Iyer, Andrew I. Webb, Dana Westphal, Grant Dewson, Jerry M. Adams. https://www.cell.com/cell-reports/fulltext/S2211-1247(19)30356-0

Bcl-2 and IP3 compete for the ligand-binding domain of IP3Rs modulating Ca2+ signaling output – Hristina Ivanova, Larry E. WagnerII, Akihiko Tanimura, Elien Vandermarliere, Tomas Luyten, Kirsten Welkenhuyzen, Kamil J. Alzayady, Liwei Wang, Kozo Hamada, Katsuhiko Mikoshiba, Humbert De Smedt, Lennart Martens, David I. Yule, Jan B. Parys, Geert Bultynck. https://link.springer.com/article/10.1007/s00018-019-03091-8

Discovery of Potent Myeloid Cell Leukemia-1 (Mcl-1) Inhibitors that Demonstrate in vivo Activity in Mouse Xenograft Models of Human Cancer – Lee T, Christov PP, Shaw S, Tarr JC, Zhao B, Veerasamy N, Jeon KO, Mills JJ, Bian Z, Sensintaffar JL, Arnold AL, Fogarty SA, Perry E, Ramsey HE, Cook R, Hollingshead M, Davis Millin M, Lee KM, Koss B, Budhraja A, Opferman JT, Kim K, Arteaga CL, Moore WJ, Olejniczak ET, Savona MR, Fesik SW. https://pubs.acs.org/doi/10.1021/acs.jmedchem.8b01991

Structural insights into BCL2 pro-survival protein interactions with the key autophagy regulator BECN1 following phosphorylation by STK4/MST1 – Erinna F. Lee, Nicholas A. Smith, Tatiana P. Soares da Costa, Nastaran Meftahi, Shenggen Yao, Tiffany J. Harris, Sharon Tran, Anne Pettikiriarachchi, Matthew A. Perugini, David W. Keizer, Marco Evangelista, Brian J. Smith and W. Douglas Fairlie. https://www.tandfonline.com/doi/full/10.1080/15548627.2018.1564557

Avoiding adsorption of Bcl-2 proteins to plasticware is important for accurate quantitation – Colin Hockings, Sweta Iyer, Rachel T. Uren and Ruth M. Kluck. https://www.nature.com/articles/s41418-019-0284-y

Interactions between cancer-associated fibroblasts and tumor cells promote MCL-1 dependency in estrogen receptor-positive breast cancers – Louault, T. L Bonneaud, C. Séveno, P. Gomez-Bougie, F. Nguyen, F. Gautier, N. Bourgeois, D. Loussouarn, O. Kerdraon, S. Barillé-Nion, P. Jézéquel, M. Campone, M. Amiot, P. P. Juin and F. Souazé. https://www.nature.com/articles/s41388-018-0635-z

Death receptors

T cells genetically engineered to overcome death signaling enhance adoptive cancer immunotherapy – Tori N. Yamamoto, Ping-Hsien Lee, Suman K. Vodnala, Devikala Gurusamy, Rigel J. Kishton, Zhiya Yu, Arash Eidizadeh, Robert Eil, Jessica Fioravanti, Luca Gattinoni, James N. Kochenderfer, Terry J. Fry, Bulent Arman Aksoy, Jeffrey E. Hammerbacher, Anthony C. Cruz, Richard M. Siegel, Nicholas P. Restifo and Christopher A. Klebanoff. https://www.jci.org/articles/view/121491

Impact of p53 status on TRAIL-mediated apoptotic and non-apoptotic signaling in cancer cells – Anna Willms, Hella Schittek, Sascha Rahn, Justyna Sosna, Ufuk Mert, Dieter Adam, Anna Trauzold. https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0214847

Necroptosis, RIPK1

Direct Activation of Human MLKL by a Select Repertoire of Inositol Phosphate Metabolites – Dan E. McNamara, Cole M. Dovey, Andrew T. Hale, Giovanni Quarato, Christy R. Grace, Cristina D. Guibao, Jonathan Diep, Amanda Nourse, Casey R. Cai, Hong Wu, Ravi C. Kalathur, Douglas R. Green, John D. York, Jan E. Carette, Tudor Moldoveanu. https://www.cell.com/cell-chemical-biology/fulltext/S2451-9456(19)30106-0

Serine 25 phosphorylation inhibits RIPK1 kinase-dependent cell death in models of infection and inflammation – Yves Dondelinger, Tom Delanghe, Dario Priem, Meghan A. Wynosky-Dolfi, Daniel Sorobetea, Diego Rojas-Rivera, Piero Giansanti, Ria Roelandt, Julia Gropengiesser, Klaus Ruckdeschel, Savvas N. Savvides, Albert J. R. Heck, Peter Vandenabeele, Igor E. Brodsky and Mathieu J. M. Bertrand. https://www.nature.com/articles/s41467-019-09690-0

RIPK1 prevents TRADD-driven, but TNFR1 independent, apoptosis during development – Holly Anderton, Esther Bandala-Sanchez, Daniel S Simpson, James A Rickard, Ashley P Ng, Ladina Di Rago, Cathrine Hall, James E Vince, John Silke, Gianmaria Liccardi and Rebecca Feltham. https://www.nature.com/articles/s41418-018-0166-8

Ferroptosis

A GPX4-dependent cancer cell state underlies the clear-cell morphology and confers sensitivity to ferroptosis – Yilong Zou, Michael J. Palte, Amy A. Deik, Haoxin Li, John K. Eaton, Wenyu Wang, Yuen-Yi Tseng, Rebecca Deasy, Maria Kost-Alimova, Vlado Dančík, Elizaveta S. Leshchiner, Vasanthi S. Viswanathan, Sabina Signoretti, Toni K. Choueiri, Jesse S. Boehm, Bridget K. Wagner, John G. Doench, Clary B. Clish, Paul A. Clemons and Stuart L. Schreiber. https://www.nature.com/articles/s41467-019-09277-9

The Deubiquitylase OTUB1 Mediates Ferroptosis via Stabilization of SLC7A11 – Tong Liu, Le Jiang, Omid Tavana and Wei Gu. http://cancerres.aacrjournals.org/content/79/8/1913

Mechanistic basis for impaired ferroptosis in cells expressing the African-centric S47 variant of p53 – Julia I-Ju Leu, Maureen E. Murphy and Donna L. George. https://www.pnas.org/content/116/17/8390.abstract?etoc

Miscellanous

Lysosomal Machinery Drives Extracellular Acidification to Direct Non-apoptotic Cell Death [of the nurse cell] – Albert A. Mondragon, Alla Yalonetskaya, Anthony J. Ortega, Yuanhang Zhang, Oandy Naranjo, Johnny Elguero, Won-Suk Chung, Kimberly McCall. https://www.cell.com/cell-reports/fulltext/S2211-1247(19)30350-X?

Comments

Methods for monitoring the progression of cell death, cell disassembly and cell clearance – Lanzhou Jiang and Ivan K. H. Poon. https://link.springer.com/article/10.1007/s10495-018-01511-x

Navigating the Fas lane to improved cellular therapy for cancer – Madhav V. Dhodapkar. https://www.jci.org/articles/view/127581

MAVS‐induced mitochondrial membrane remodeling – Hector Flores‐Romero, Ana J. García‐Sáez. https://febs.onlinelibrary.wiley.com/doi/10.1111/febs.14822

DUBbing Ferroptosis in Cancer Cells – Boyi Gan. http://cancerres.aacrjournals.org/content/79/8/1749

Conference: NON-APOPTOTIC ROLES OF APOPTOTIC PROTEINS

September 22-25, 2019, Weizmann Institute of Science

http://www.weizmann.ac.il/conferences/CDPs2019/

cris

ApoList – March 2019

Caspases, metacaspases and IAPs

Apoptotic Caspases Suppress Type I Interferon Production via the Cleavage of cGAS, MAVS, and IRF3 – Xiaohan Ning, Yutao Wang, Miao Jing, Mengyin Sha, Mengze Lv, P engfei Gao, Rui Zhang, Xiaojun Huang, Ji-Ming Feng, Zhengfan Jiang. https://www.cell.com/molecular-cell/fulltext/S1097-2765(19)30103-0

Damage on plants activates Ca2+-dependent metacaspases for release of immunomodulatory peptides – Tim Hander, Álvaro D. Fernández-Fernández, Robert P. Kumpf, Patrick Willems, Hendrik Schatowitz, Debbie Rombaut, An Staes, Jonah Nolf, Robin Pottie, Panfeng Yao, Amanda Gonçalves, Benjamin Pavie, Thomas Boller, Kris Gevaert, Frank Van Breusegem, Sebastian Bartels, Simon Stael. http://science.sciencemag.org/content/363/6433/eaar7486

The Caspase-3 homolog DrICE regulates endocytic trafficking during Drosophila tracheal morphogenesis – Saoirse S. McSharry and Greg J. Beitel. https://www.nature.com/articles/s41467-019-09009-z

The RING domain in the anti-apoptotic protein XIAP stabilizes c-Myc protein and preserves anchorage-independent growth of bladder cancer cells – Guosong Jiang, Chao Huang, Xin Liao, Jingxia Li, Xue-Ru Wu, Fuqing Zeng and Chuanshu Huang. http://www.jbc.org/content/early/2019/02/28/jbc.RA118.005621.abstract

Necroptosis, RIP kinases

RIPK1 can mediate apoptosis in addition to necroptosis during embryonic development – Xuhua Zhang, John P. Dowling and Jianke Zhang. https://www.nature.com/articles/s41419-019-1490-8

Identification of a novel class of RIP1/RIP3 dual inhibitors that impede cell death and inflammation in mouse abdominal aortic aneurysm models – Ting Zhou, Qiwei Wang, Noel Phan, Jun Ren, Huan Yang, Conner C. Feldman, John B. Feltenberger, Zhengqing Ye, Scott A. Wildman, Weiping Tang and Bo Liu. https://www.nature.com/articles/s41419-019-1468-6

O-GlcNAc Transferase Suppresses Inflammation and Necroptosis by Targeting Receptor-Interacting Serine/Threonine-Protein Kinase 3 – Xinghui Li, Wei Gong, Hao Wang, Tianliang Li, Kuldeep S. Attri, Robert E. Lewis, Andre C. Kalil, Fatema Bhinderwala, Robert Powers, Guowei Yin, Laura E. Herring, John M. Asara, Yu L. Lei, Xiaoyong Yang, Diego A. Rodriguez, Mao Yang, Douglas R. Green, Pankaj K. Singh, Haitao Wen. https://www.cell.com/immunity/fulltext/S1074-7613(19)30030-5

RIP1 kinase inhibitor halts the progression of an immune-induced demyelination disease at the stage of monocyte elevation – Sitao Zhang, Yaning Su, Zhengxin Ying, Dejia Guo, Chenjie Pan, Jia Guo, Ziye Zou, Lei Wang, Ze Zhang, Zhaodi Jiang, Zhiyuan Zhang and Xiaodong Wang. https://www.pnas.org/content/116/12/5675.abstract?etoc

Activated MLKL attenuates autophagy following its translocation to intracellular membranes – Daniel Frank, David L. Vaux, James M. Murphy, James E. Vince and Lisa M. Lindqvist. http://jcs.biologists.org/content/132/5/jcs220996?etoc

Other non-apoptotic forms of cell death

Entosis Controls a Developmental Cell Clearance in C. elegans – Yongchan Lee, Jens C. Hamann, Mark Pellegrino, Joanne Durgan, Marie-Charlotte Domart, Lucy M. Collinson, Cole M. Haynes, Oliver Florey, Michael Overholtzer. https://www.cell.com/cell-reports/fulltext/S2211-1247(19)30252-9

Drosophila p53 directs non-apoptotic programs in postmitotic tissue – Paula Kurtz, Amanda E. Jones, Bhavana Tiwari, Nichole Link, Annika Wylie, Charles Tracy, Helmut Krämer and John M. Abrams. https://www.molbiolcell.org/doi/abs/10.1091/mbc.E18-12-0791

A major role for ferroptosis in Mycobacterium tuberculosis–induced cell death and tissue necrosis – Eduardo P. Amaral, Diego L. Costa, Sivaranjani Namasivayam, Nicolas Riteau, Olena Kamenyeva, Lara Mittereder, Katrin D. Mayer-Barber, Bruno B. Andrade and Alan Sher. http://jem.rupress.org/content/216/3/556?etoc

Efferocytosis and cell-cell communication

Apoptotic tumor cell-derived microRNA-375 uses CD36 to alter the tumor-associated macrophage phenotype – Ann-Christin Frank, Stefanie Ebersberger, Annika F. Fink, Sebastian Lampe, Andreas Weigert, Tobias Schmid, Ingo Ebersberger, Shahzad Nawaz Syed and Bernhard Brüne. https://www.nature.com/articles/s41467-019-08989-2

Bcl-2 family proteins

A Phase Ib Dose-Escalation and Expansion Study of the BCL2 Inhibitor Venetoclax Combined with Tamoxifen in ER and BCL2–Positive Metastatic Breast Cancer – Sheau W. Lok, James R. Whittle, François Vaillant, Charis E. Teh, Louisa L. Lo, Antonia N. Policheni, Alice R.T. Bergin, Jayesh Desai, Sarah Ftouni, Luke C. Gandolfo, Danny Liew, He K. Liu, G. Bruce Mann, Kate Moodie, Anand Murugasu, Bhupinder Pal, Andrew W. Roberts, Mark A. Rosenthal, Kylie Shackleton, Maria João Silva, Zhen R. Siow, Gordon K. Smyth, Leanne Taylor, Avraham Travers, Belinda Yeo, Miriam M. Yeung, Andjelija Zivanovic Bujak, Sarah-Jane Dawson, Daniel H.D. Gray, Jane E. Visvader and Geoffrey J. Lindeman. http://cancerdiscovery.aacrjournals.org/content/9/3/354

Bim escapes displacement by BH3-mimetic anti-cancer drugs by double-bolt locking both Bcl-XL and Bcl-2 – Qian Liu, Elizabeth J Oesterlund, Xiaoke Chi, Justin Pogmore, Brian Leber, David William Andrews. https://elifesciences.org/articles/37689

Acquisition of the Recurrent Gly101Val Mutation in BCL2 Confers Resistance to Venetoclax in Patients with Progressive Chronic Lymphocytic Leukemia – Piers Blombery, Mary Ann Anderson, Jia-nan Gong, Rachel Thijssen, Richard W. Birkinshaw, Ella R. Thompson, Charis E. Teh, Tamia Nguyen, Zhen Xu, Christoffer Flensburg, Thomas E. Lew, Ian J. Majewski, Daniel H.D. Gray, David A. Westerman, Constantine S. Tam, John F. Seymour, Peter E. Czabotar, David C.S. Huang and Andrew W. Roberts. http://cancerdiscovery.aacrjournals.org/content/9/3/342

The Ewing Family of Tumors Relies on BCL-2 and BCL-XL to Escape PARP Inhibitor Toxicity – Daniel A.R. Heisey, Timothy L. Lochmann, Konstantinos V. Floros, Colin M. Coon, Krista M. Powell, Sheeba Jacob, Marissa L. Calbert, Maninderjit S. Ghotra, Giovanna T. Stein, Yuki Kato Maves, Steven C. Smith, Cyril H. Benes, Joel D. Leverson, Andrew J. Souers, Sosipatros A. Boikos and Anthony C. Faber. http://clincancerres.aacrjournals.org/content/25/5/1664

Retromer facilitates the localization of Bcl-xL to the mitochondrial outer membrane – Trey Farmer, Katelyn L. O’Neill, Naava Naslavsky, Xu Luo and Steve Caplan. https://www.molbiolcell.org/doi/10.1091/mbc.E19-01-0044?ai=25zg&ui=2oy6&af=T

Mitochondrial origins of fractional control in regulated cell death – Luís C. Santos, Robert Vogel, Jerry E. Chipuk, Marc R. Birtwistle, Gustavo Stolovitzky and Pablo Meyer. https://www.nature.com/articles/s41467-019-09275-x

Miscellanous

MDM2 Integrates Cellular Respiration and Apoptotic Signaling through NDUFS1 and the Mitochondrial Network – Rana Elkholi, Ioana Abraham-Enachescu, Andrew P. Trotta, Camila Rubio-Patiño, Jarvier N. Mohammed, Mark P.A. Luna-Vargas, Jesse D. Gelles, Joshua R. Kaminetsky, Madhavika N. Serasinghe, Cindy Zou, Sumaira Ali, Gavin P. McStay, Cathie M. Pfleger, Jerry Edward Chipuk. https://www.cell.com/molecular-cell/fulltext/S1097-2765(19)30102-9

Ran1 is essential for parental macronuclear import of apoptosis‐inducing factor and programmed nuclear death in Tetrahymena thermophila – Haixia Liang, Jing Xu, Wei Wang. https://febs.onlinelibrary.wiley.com/doi/10.1111/febs.14761

Reviews

Autophagy-dependent cell death – Donna Denton and Sharad Kumar. https://www.nature.com/articles/s41418-018-0252-y

Intersections between Regulated Cell Death and Autophagy – Francesco Napoletano, Olga Baron, Peter Vandenabeele, Bertrand Mollereau, Manolis Fanto. https://www.cell.com/trends/cell-biology/fulltext/S0962-8924(18)30237-X

LC3-associated phagocytosis at a glance – Bradlee L. Heckmann and Douglas R. Green. http://jcs.biologists.org/content/132/5/jcs222984?etoc

Enzymatically oxidized phospholipids assume center stage as essential regulators of innate immunity and cell death – Valerie B. O’Donnell , Maceler Aldrovandi, Robert C. Murphy, Gerhard Krönke. http://stke.sciencemag.org/content/12/574/eaau2293

Oxidative stress, eryptosis and anemia: a pivotal mechanistic nexus in systemic diseases – Rosi Bissinger, Abdulla Al Mamun Bhuyan, Syed M. Qadri, Florian Lang. https://febs.onlinelibrary.wiley.com/doi/10.1111/febs.14606

Comments / other

Cheating Death: New Molecules Block BAX – Loren D. Walensky. https://www.cell.com/trends/molecular-medicine/fulltext/S1471-4914(19)30043-7

The good, the bad and the autophagosome: exploring unanswered questions of autophagy-dependent cell death – Jurgen Kriel and Ben Loos. https://www.nature.com/articles/s41418-018-0267-4

Interview: a conversation with Vishva M Dixit on his journey from remote African village to apoptosis, necroptosis and the inflammasome – Vishva M. Dixit. https://www.nature.com/articles/s41418-019-0294-9?

Gly101Val BCL2 Mutation: One Step Closer to Understanding Venetoclax Resistance in CLL – Shanmugapriya Thangavadivel and John C. Byrd. http://cancerdiscovery.aacrjournals.org/content/9/3/320

Targeting Apoptosis: A New Paradigm for the Treatment of Estrogen Receptor–Positive Breast Cancer – Joshua Z. Drago, Sarat Chandarlapaty and Komal Jhaveri. http://cancerdiscovery.aacrjournals.org/content/9/3/323

 

EMBO Workshop: Cell death in immunity and inflammation

06 – 09 October 2019 | Crete, Greece. Organized by Manolis Pasparakis and Núria Sánchez-Coll

http://meetings.embo.org/event/19-cell-death