ApoList – March 2019

Caspases, metacaspases and IAPs

Apoptotic Caspases Suppress Type I Interferon Production via the Cleavage of cGAS, MAVS, and IRF3 – Xiaohan Ning, Yutao Wang, Miao Jing, Mengyin Sha, Mengze Lv, P engfei Gao, Rui Zhang, Xiaojun Huang, Ji-Ming Feng, Zhengfan Jiang. https://www.cell.com/molecular-cell/fulltext/S1097-2765(19)30103-0

Damage on plants activates Ca2+-dependent metacaspases for release of immunomodulatory peptides – Tim Hander, Álvaro D. Fernández-Fernández, Robert P. Kumpf, Patrick Willems, Hendrik Schatowitz, Debbie Rombaut, An Staes, Jonah Nolf, Robin Pottie, Panfeng Yao, Amanda Gonçalves, Benjamin Pavie, Thomas Boller, Kris Gevaert, Frank Van Breusegem, Sebastian Bartels, Simon Stael. http://science.sciencemag.org/content/363/6433/eaar7486

The Caspase-3 homolog DrICE regulates endocytic trafficking during Drosophila tracheal morphogenesis – Saoirse S. McSharry and Greg J. Beitel. https://www.nature.com/articles/s41467-019-09009-z

The RING domain in the anti-apoptotic protein XIAP stabilizes c-Myc protein and preserves anchorage-independent growth of bladder cancer cells – Guosong Jiang, Chao Huang, Xin Liao, Jingxia Li, Xue-Ru Wu, Fuqing Zeng and Chuanshu Huang. http://www.jbc.org/content/early/2019/02/28/jbc.RA118.005621.abstract

Necroptosis, RIP kinases

RIPK1 can mediate apoptosis in addition to necroptosis during embryonic development – Xuhua Zhang, John P. Dowling and Jianke Zhang. https://www.nature.com/articles/s41419-019-1490-8

Identification of a novel class of RIP1/RIP3 dual inhibitors that impede cell death and inflammation in mouse abdominal aortic aneurysm models – Ting Zhou, Qiwei Wang, Noel Phan, Jun Ren, Huan Yang, Conner C. Feldman, John B. Feltenberger, Zhengqing Ye, Scott A. Wildman, Weiping Tang and Bo Liu. https://www.nature.com/articles/s41419-019-1468-6

O-GlcNAc Transferase Suppresses Inflammation and Necroptosis by Targeting Receptor-Interacting Serine/Threonine-Protein Kinase 3 – Xinghui Li, Wei Gong, Hao Wang, Tianliang Li, Kuldeep S. Attri, Robert E. Lewis, Andre C. Kalil, Fatema Bhinderwala, Robert Powers, Guowei Yin, Laura E. Herring, John M. Asara, Yu L. Lei, Xiaoyong Yang, Diego A. Rodriguez, Mao Yang, Douglas R. Green, Pankaj K. Singh, Haitao Wen. https://www.cell.com/immunity/fulltext/S1074-7613(19)30030-5

RIP1 kinase inhibitor halts the progression of an immune-induced demyelination disease at the stage of monocyte elevation – Sitao Zhang, Yaning Su, Zhengxin Ying, Dejia Guo, Chenjie Pan, Jia Guo, Ziye Zou, Lei Wang, Ze Zhang, Zhaodi Jiang, Zhiyuan Zhang and Xiaodong Wang. https://www.pnas.org/content/116/12/5675.abstract?etoc

Activated MLKL attenuates autophagy following its translocation to intracellular membranes – Daniel Frank, David L. Vaux, James M. Murphy, James E. Vince and Lisa M. Lindqvist. http://jcs.biologists.org/content/132/5/jcs220996?etoc

Other non-apoptotic forms of cell death

Entosis Controls a Developmental Cell Clearance in C. elegans – Yongchan Lee, Jens C. Hamann, Mark Pellegrino, Joanne Durgan, Marie-Charlotte Domart, Lucy M. Collinson, Cole M. Haynes, Oliver Florey, Michael Overholtzer. https://www.cell.com/cell-reports/fulltext/S2211-1247(19)30252-9

Drosophila p53 directs non-apoptotic programs in postmitotic tissue – Paula Kurtz, Amanda E. Jones, Bhavana Tiwari, Nichole Link, Annika Wylie, Charles Tracy, Helmut Krämer and John M. Abrams. https://www.molbiolcell.org/doi/abs/10.1091/mbc.E18-12-0791

A major role for ferroptosis in Mycobacterium tuberculosis–induced cell death and tissue necrosis – Eduardo P. Amaral, Diego L. Costa, Sivaranjani Namasivayam, Nicolas Riteau, Olena Kamenyeva, Lara Mittereder, Katrin D. Mayer-Barber, Bruno B. Andrade and Alan Sher. http://jem.rupress.org/content/216/3/556?etoc

Efferocytosis and cell-cell communication

Apoptotic tumor cell-derived microRNA-375 uses CD36 to alter the tumor-associated macrophage phenotype – Ann-Christin Frank, Stefanie Ebersberger, Annika F. Fink, Sebastian Lampe, Andreas Weigert, Tobias Schmid, Ingo Ebersberger, Shahzad Nawaz Syed and Bernhard Brüne. https://www.nature.com/articles/s41467-019-08989-2

Bcl-2 family proteins

A Phase Ib Dose-Escalation and Expansion Study of the BCL2 Inhibitor Venetoclax Combined with Tamoxifen in ER and BCL2–Positive Metastatic Breast Cancer – Sheau W. Lok, James R. Whittle, François Vaillant, Charis E. Teh, Louisa L. Lo, Antonia N. Policheni, Alice R.T. Bergin, Jayesh Desai, Sarah Ftouni, Luke C. Gandolfo, Danny Liew, He K. Liu, G. Bruce Mann, Kate Moodie, Anand Murugasu, Bhupinder Pal, Andrew W. Roberts, Mark A. Rosenthal, Kylie Shackleton, Maria João Silva, Zhen R. Siow, Gordon K. Smyth, Leanne Taylor, Avraham Travers, Belinda Yeo, Miriam M. Yeung, Andjelija Zivanovic Bujak, Sarah-Jane Dawson, Daniel H.D. Gray, Jane E. Visvader and Geoffrey J. Lindeman. http://cancerdiscovery.aacrjournals.org/content/9/3/354

Bim escapes displacement by BH3-mimetic anti-cancer drugs by double-bolt locking both Bcl-XL and Bcl-2 – Qian Liu, Elizabeth J Oesterlund, Xiaoke Chi, Justin Pogmore, Brian Leber, David William Andrews. https://elifesciences.org/articles/37689

Acquisition of the Recurrent Gly101Val Mutation in BCL2 Confers Resistance to Venetoclax in Patients with Progressive Chronic Lymphocytic Leukemia – Piers Blombery, Mary Ann Anderson, Jia-nan Gong, Rachel Thijssen, Richard W. Birkinshaw, Ella R. Thompson, Charis E. Teh, Tamia Nguyen, Zhen Xu, Christoffer Flensburg, Thomas E. Lew, Ian J. Majewski, Daniel H.D. Gray, David A. Westerman, Constantine S. Tam, John F. Seymour, Peter E. Czabotar, David C.S. Huang and Andrew W. Roberts. http://cancerdiscovery.aacrjournals.org/content/9/3/342

The Ewing Family of Tumors Relies on BCL-2 and BCL-XL to Escape PARP Inhibitor Toxicity – Daniel A.R. Heisey, Timothy L. Lochmann, Konstantinos V. Floros, Colin M. Coon, Krista M. Powell, Sheeba Jacob, Marissa L. Calbert, Maninderjit S. Ghotra, Giovanna T. Stein, Yuki Kato Maves, Steven C. Smith, Cyril H. Benes, Joel D. Leverson, Andrew J. Souers, Sosipatros A. Boikos and Anthony C. Faber. http://clincancerres.aacrjournals.org/content/25/5/1664

Retromer facilitates the localization of Bcl-xL to the mitochondrial outer membrane – Trey Farmer, Katelyn L. O’Neill, Naava Naslavsky, Xu Luo and Steve Caplan. https://www.molbiolcell.org/doi/10.1091/mbc.E19-01-0044?ai=25zg&ui=2oy6&af=T

Mitochondrial origins of fractional control in regulated cell death – Luís C. Santos, Robert Vogel, Jerry E. Chipuk, Marc R. Birtwistle, Gustavo Stolovitzky and Pablo Meyer. https://www.nature.com/articles/s41467-019-09275-x


MDM2 Integrates Cellular Respiration and Apoptotic Signaling through NDUFS1 and the Mitochondrial Network – Rana Elkholi, Ioana Abraham-Enachescu, Andrew P. Trotta, Camila Rubio-Patiño, Jarvier N. Mohammed, Mark P.A. Luna-Vargas, Jesse D. Gelles, Joshua R. Kaminetsky, Madhavika N. Serasinghe, Cindy Zou, Sumaira Ali, Gavin P. McStay, Cathie M. Pfleger, Jerry Edward Chipuk. https://www.cell.com/molecular-cell/fulltext/S1097-2765(19)30102-9

Ran1 is essential for parental macronuclear import of apoptosis‐inducing factor and programmed nuclear death in Tetrahymena thermophila – Haixia Liang, Jing Xu, Wei Wang. https://febs.onlinelibrary.wiley.com/doi/10.1111/febs.14761


Autophagy-dependent cell death – Donna Denton and Sharad Kumar. https://www.nature.com/articles/s41418-018-0252-y

Intersections between Regulated Cell Death and Autophagy – Francesco Napoletano, Olga Baron, Peter Vandenabeele, Bertrand Mollereau, Manolis Fanto. https://www.cell.com/trends/cell-biology/fulltext/S0962-8924(18)30237-X

LC3-associated phagocytosis at a glance – Bradlee L. Heckmann and Douglas R. Green. http://jcs.biologists.org/content/132/5/jcs222984?etoc

Enzymatically oxidized phospholipids assume center stage as essential regulators of innate immunity and cell death – Valerie B. O’Donnell , Maceler Aldrovandi, Robert C. Murphy, Gerhard Krönke. http://stke.sciencemag.org/content/12/574/eaau2293

Oxidative stress, eryptosis and anemia: a pivotal mechanistic nexus in systemic diseases – Rosi Bissinger, Abdulla Al Mamun Bhuyan, Syed M. Qadri, Florian Lang. https://febs.onlinelibrary.wiley.com/doi/10.1111/febs.14606

Comments / other

Cheating Death: New Molecules Block BAX – Loren D. Walensky. https://www.cell.com/trends/molecular-medicine/fulltext/S1471-4914(19)30043-7

The good, the bad and the autophagosome: exploring unanswered questions of autophagy-dependent cell death – Jurgen Kriel and Ben Loos. https://www.nature.com/articles/s41418-018-0267-4

Interview: a conversation with Vishva M Dixit on his journey from remote African village to apoptosis, necroptosis and the inflammasome – Vishva M. Dixit. https://www.nature.com/articles/s41418-019-0294-9?

Gly101Val BCL2 Mutation: One Step Closer to Understanding Venetoclax Resistance in CLL – Shanmugapriya Thangavadivel and John C. Byrd. http://cancerdiscovery.aacrjournals.org/content/9/3/320

Targeting Apoptosis: A New Paradigm for the Treatment of Estrogen Receptor–Positive Breast Cancer – Joshua Z. Drago, Sarat Chandarlapaty and Komal Jhaveri. http://cancerdiscovery.aacrjournals.org/content/9/3/323


EMBO Workshop: Cell death in immunity and inflammation

06 – 09 October 2019 | Crete, Greece. Organized by Manolis Pasparakis and Núria Sánchez-Coll



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