Death receptors
Identification of FasL as a crucial host factor driving COVID-19 pathology and lethality – Marie-Christine Albert, Iratxe Uranga-Murillo, Maykel Arias, Diego De Miguel, Natacha Peña, Antonella Montinaro, Ana Beatriz Varanda, Sebastian J. Theobald, Itziar Areso, Julia Saggau, Manuel Koch, Gianmaria Liccardi, Nieves Peltzer, Jan Rybniker, Ramón Hurtado-Guerrero, Pedro Merino, Marta Monzón, Juan J. Badiola, Roman Reindl-Schwaighofer, Rebeca Sanz-Pamplona, Alberto Cebollada-Solanas, Zsolt Megyesfalvi, Balazs Dome, Maria Secrier, Boris Hartmann, Michael Bergmann, Julián Pardo and Henning Walczak. https://www.nature.com/articles/s41418-024-01278-6
METTL16 deficiency attenuates apoptosis through translational control of extrinsic death receptor during nutrient deprivation – Qiujie Li, Lu Yang, Chenxin Zhang, Jingying Yuan, Jun Zhang, Wenjun Tao, Jun Zhou. https://linkinghub.elsevier.com/retrieve/pii/S0006-291X(24)00338-3
Enhanced CD95 and interleukin 18 signalling accompany T cell receptor Vβ21.3+ activation in multi-inflammatory syndrome in children – Zhenguang Zhang, Iain R. L. Kean, Lisa M. Dratva, John A. Clark, Eleni Syrimi, Naeem Khan, Esther Daubney, Deborah White, Lauran O’Neill, Catherine Chisholm, Caroline Payne, Sarah Benkenstein, Klaudia Kupiec, Rachel Galassini, Victoria Wright, Helen Winmill, Ceri Robbins, Katherine Brown, Padmanabhan Ramnarayan, Barnaby Scholefield, Mark Peters, Nigel Klein, Hugh Montgomery, Kerstin B. Meyer, Sarah A. Teichmann, Clare Bryant, Graham Taylor and Nazima Pathan. https://www.nature.com/articles/s41467-024-48699-y
Caspases
Deciphering DED assembly mechanisms in FADD-procaspase-8-cFLIP complexes regulating apoptosis – Chao-Yu Yang, Chia-I Lien, Yi-Chun Tseng, Yi-Fan Tu, Arkadiusz W. Kulczyk, Yen-Chen Lu, Yin-Ting Wang, Tsung-Wei Su, Li-Chung Hsu, Yu-Chih Lo and Su-Chang Lin. https://www.nature.com/articles/s41467-024-47990-2
Transient caspase-mediated activation of caspase-activated DNase causes DNA damage required for phagocytic macrophage differentiation – Deepak Maurya, Gayatri Rai, Debleena Mandal, Bama Charan Mondal. https://www.cell.com/cell-reports/fulltext/S2211-1247(24)00579-5
Arginine methylation of caspase-8 controls life/death decisions in extrinsic apoptotic networks – Fabian Wohlfromm, Nikita V. Ivanisenko, Sabine Pietkiewicz, Corinna König, Kamil Seyrek, Thilo Kähne and Inna N. Lavrik. https://www.nature.com/articles/s41388-024-03049-6
Study of the potential role of CASPASE-10 mutations in the development of autoimmune lymphoproliferative syndrome – Filippo Consonni, Solange Moreno, Blanca Vinuales Colell, Marie-Claude Stolzenberg, Alicia Fernandes, Mélanie Parisot, Cécile Masson, Nathalie Neveux, Jérémie Rosain, Sarah Bamberger, Marie-Gabrielle Vigue, Marion Malphettes, Pierre Quartier, Capucine Picard, Frédéric Rieux-Laucat and Aude Magerus. https://www.nature.com/articles/s41419-024-06679-6
Phosphorylation of caspase-8 by RSKs via organ-constrained effects controls the sensitivity to TNF-induced death – Peng He, Tingting Ai, Muzhen Qiao, Zhang-Hua Yang and Jiahuai Han. https://www.nature.com/articles/s41420-024-02024-0
Ketogenic diet induces p53-dependent cellular senescence in multiple organs [caspase-2] – Wei SJ, Schell JR, Chocron ES, Varmazyad M, Xu G, Chen WH, Martinez GM, Dong FF, Sreenivas P, Trevino R Jr, Jiang H, Du Y, Saliba A, Qian W, Lorenzana B, Nazarullah A, Chang J, Sharma K, Munkácsy E, Horikoshi N, Gius D. https://www.science.org/doi/10.1126/sciadv.ado1463
Necroptosis / MLKL
RIPK3 cleavage is dispensable for necroptosis inhibition but restricts NLRP3 inflammasome activation – Hong Tri Tran, Tobias Kratina, Auriane Coutansais, Dominika Michalek, Benjamin M. Hogan, Kate E. Lawlor, James E. Vince, John Silke and Najoua Lalaoui. https://www.nature.com/articles/s41418-024-01281-x
The importance of murine phospho-MLKL-S345 in situ detection for necroptosis assessment in vivo – Konstantinos Kelepouras, Julia Saggau, Ana Beatriz Varanda, Matea Zrilic, Christine Kiefer, Hassan Rakhsh-Khorshid, Ina Lisewski, Iratxe Uranga-Murillo, Maykel Arias, Julian Pardo, Wulf Tonnus, Andreas Linkermann, Alessandro Annibaldi, Henning Walczak and Gianmaria Liccardi. https://www.nature.com/articles/s41418-024-01313-6
MLKL, a new actor of UVB-induced apoptosis in human diploid dermal fibroblasts – Anne-Sophie Gary, Sophie Amouret, Alicia Montoni and Patrick J. Rochette. https://www.nature.com/articles/s41420-024-02004-4
ZBP1
ZBP1-mediated apoptosis and inflammation exacerbate steatotic liver ischemia-reperfusion injury – Ran Liu, Huan Cao, Shuhua Zhang, Mao Cai, Tianhao Zou, Guoliang Wang, Di Zhang, Xueling Wang, Jianjun Xu, Shenghe Deng, Tongxi Li, Daichao Xu, and Jinyang Gu. https://www.jci.org/articles/view/180451
ZBP1 and TRIF trigger lethal necroptosis in mice lacking caspase-8 and TNFR1 – Margaret Solon, Nianfeng Ge, Shannon Hambro, Susan Haller, Jian Jiang, Miriam Baca, Jessica Preston, Allie Maltzman, Katherine E. Wickliffe, Yuxin Liang, Rohit Reja, Dorothee Nickles, Kim Newton and Joshua D. Webster. https://www.nature.com/articles/s41418-024-01286-6
A ZBP1 isoform blocks ZBP1-mediated cell death – Zhi-Yu Cai, Puqi Wu, Hao Liang, Yu-Ze Xie, Bo-Xin Zhang, Cai-Ling He, Cong-Rong Yang, Hongda Li, Wei Mo, Zhang-Hua Yang. https://www.cell.com/cell-reports/fulltext/S2211-1247(24)00549-7
Bcl-2 family proteins
Putting the STING back into BH3-mimetic drugs for TP53-mutant blood cancers – Sarah T. Diepstraten, Yin Yuan, John E. La Marca, Savannah Young, Catherine Chang, Lauren Whelan, Aisling M. Ross, Karla C. Fischer, Giovanna Pomilio, Rhiannon Morris, Angela Georgiou, Veronique Litalien, Fiona C. Brown, Andrew W. Roberts, Andreas Strasser, Andrew H. Wei, Gemma L. Kelly. https://www.cell.com/cancer-cell/fulltext/S1535-6108(24)00128-4
Novel markers of MCL1 inhibitor sensitivity in triple negative breast cancer cells – Lei Duan, Mehrdad Jafari Tadi, Kelsey M. O’Hara, Carl G. Maki. https://www.jbc.org/article/S0021-9258(24)01876-3/fulltext
Decreased apoptotic priming and loss of BCL-2 dependence are functional hallmarks of Richter’s syndrome – Antonella Rigo, Tiziana Vaisitti, Carlo Laudanna, Eleonora Terrabuio, Matilde Micillo, Cristina Frusteri, Beatrice D’Ulivo, Flavia Merigo, Andrea Sbarbati, Kevin Mellert, Peter Möeller, Alessio Montresor, Arianna Di Napoli, Roberto Cirombella, Elena Butturini, Massimo Massaia, Gabriela Constantin, Fabrizio Vinante, Silvia Deaglio and Isacco Ferrarini. https://www.nature.com/articles/s41419-024-06707-5
Pyroptosis, Gasdermins
Cleavage-independent activation of ancient eukaryotic gasdermins and structural mechanisms – Li Y, Hou Y, Sun Q, Zeng H, Meng F, Tian X, He Q, Shao F, Ding J. https://www.science.org/doi/10.1126/science.adm9190
A palmitoylation–depalmitoylation relay spatiotemporally controls GSDMD activation in pyroptosis – Na Zhang, Jian Zhang, Yuanxin Yang, Hengyue Shan, Shouqiao Hou, Hongwen Fang, Min Ma, Zhongwen Chen, Li Tan and Daichao Xu. https://www.nature.com/articles/s41556-024-01397-9
Ferroptosis
Lipid-derived electrophiles inhibit the function of membrane channels during ferroptosis – Antonius T. M. Van Kessel and Gonzalo Cosa. https://www.pnas.org/doi/10.1073/pnas.2317616121
Efferocytosis, entosis etc
Efferocytosis reprograms the tumor microenvironment to promote pancreatic cancer liver metastasis – Yuliana Astuti, Meirion Raymant, Valeria Quaranta, Kim Clarke, Maidinaimu Abudula, Olivia Smith, Gaia Bellomo, Vatshala Chandran-Gorner, Craig Nourse, Christopher Halloran, Paula Ghaneh, Daniel Palmer, Robert P. Jones, Fiona Campbell, Jeffrey W. Pollard, Jennifer P. Morton, Ainhoa Mielgo and Michael C. Schmid. https://www.nature.com/articles/s43018-024-00731-2
Resolvin E1 improves efferocytosis and rescues severe aplastic anemia in mice – Rachel Grazda, Allison N. Seyfried, Krishna Rao Maddipati, Gabrielle Fredman and Katherine C. MacNamara. https://www.nature.com/articles/s41419-024-06705-7
Cytotoxicity
Targeting senescent cells with NKG2D-CAR T cells – Yushuang Deng, Avadh Kumar, Kan Xie, Kristina Schaaf, Enzo Scifo, Sarah Morsy, Tao Li, Armin Ehninger, Daniele Bano and Dan Ehninger. https://www.nature.com/articles/s41420-024-01976-7
Pretreatment with IL-15 and IL-18 rescues natural killer cells from granzyme B-mediated apoptosis after cryopreservation – Abdulla Berjis, Deeksha Muthumani, Oscar A. Aguilar, Oz Pomp, Omar Johnson, Amanda V. Finck, Nils W. Engel, Linhui Chen, Nicolas Plachta, John Scholler, Lewis L. Lanier, Carl H. June and Neil C. Sheppard. https://www.nature.com/articles/s41467-024-47574-0
Miscellanous
Synthetic protein circuits for programmable control of mammalian cell death – Shiyu Xia, Andrew C. Lu, Victoria Tobin, Kaiwen Luo, Lukas Moeller, D. Judy Shon, Rongrong Du, James M. Linton, Margaret Sui, Felix Horns, Michael B. Elowitz. https://www.cell.com/cell/fulltext/S0092-8674(24)00347-7
Cardiolipin oxidized by ROS from complex II acts as a target of gasdermin D to drive mitochondrial pore and heart dysfunction in endotoxemia – Yan Tang, Junru Wu, Xuejing Sun, Shasha Tan, Wenbo Li, Siyu Yin, Lun Liu, Yuanyuan Chen, Yuanyuan Liu, Qian Tan, Youxiang Jiang, Wenjing Yang, Wei Huang, Chunyan Weng, Qing Wu, Yao Lu, Hong Yuan, Qingzhong Xiao, Alex F. Chen, Qingbo Xu, Timothy R. Billiar, Jingjing Cai. https://www.cell.com/cell-reports/fulltext/S2211-1247(24)00565-5
Reviews
Ferroptosis in Health and Disease – Carsten Berndt, Hamed Alborzinia, Vera Skafar Amen, Scott Ayton, Uladzimir Barayeu, Alexander Bartelt, Hülya Bayir, Christina M. Bebber, Kivanc Birsoy, Jan P. Böttcher, Simone Brabletz, Thomas Brabletz, Ashley R. Brown, Bernhard Brüne, Giorgia Bulli, Alix Bruneau, Quan Chen, Gina M. DeNicola, Tobias P. Dick, Ayelén Distéfano, Scott J. Dixon, Jan B. Engler, Julia Esser-von Bieren, Maria Fedorova, José Pedro Friedmann Angeli, Manuel A. Friese, Dominic C. Fuhrmann, Ana J. García-Sáez, Karolina Garbowicz, Magdalena Götz, Wei Gu, Linda Hammerich, Behrouz Hassannia, Xuejun Jiang, Aicha Jeridi, Yun Pyo Kang, Valerian E. Kagan, David B. Konrad, Stefan Kotschi, Peng Lei, Marlène Le Tertre, Sima Lev, Deguang Liang, Andreas Linkermann, Carolin Lohr, Svenja Lorenz, Tom Luedde, Axel Methner, Bernhard Michalke, Anna V. Milton, Junxia Min, Eikan Mishima, Sebastian Müller, Hozumi Motohashi, Martina U. Muckenthaler, Shohei Murakami, James A. Olzmann, Gabriela Pagnussat, Zijan Pan, Thales Papagiannakopoulos, Lohans Pedrera Puentes, Derek A. Pratt, Bettina Proneth, Lukas Ramsauer, Raphael Rodriguez, Yoshiro Saito, Felix Schmidt, Carina Schmitt, Almut Schulze, Annemarie Schwab, Anna Schwantes, Mariluz Soula, Benedikt Spitzlberger, Brent R. Stockwell, Leonie Thewes, Oliver Thorn-Seshold, Shinya Toyokuni, Wulf Tonnus, Andreas Trumpp, Peter Vandenabeele, Tom Vanden Berghe, Vivek Venkataramani, Felix C.E. Vogel, Silvia von Karstedt, Fudi Wang, Frank Westermann, Chantal Wientjens, Christoph Wilhelm, Michele Wölk, Katherine Wu, Xin Yang, Fan Yu, Yilong Zou, Marcus Conrad. https://www.sciencedirect.com/science/article/pii/S2213231724001897
The cell biology of ferroptosis – Scott J. Dixon and James A. Olzmann. https://www.nature.com/articles/s41580-024-00703-5
Ironing out the role of ferroptosis in immunity – Hannah N. Bell, Brent R. Stockwell, Weiping Zou. https://www.cell.com/immunity/fulltext/S1074-7613(24)00140-7
A guide to the expanding field of extracellular vesicles and their release in regulated cell death programs – Benjamin Cappe, Peter Vandenabeele, Franck B. Riquet. https://febs.onlinelibrary.wiley.com/doi/full/10.1111/febs.16981?campaign=woletoc
Immunogenicity of ferroptosis in cancer: a matter of context? – Elena Catanzaro, Robin Demuynck, Faye Naessens, Lorenzo Galluzzi, Dmitri V. Krysko. https://www.cell.com/trends/cancer/fulltext/S2405-8033(24)00013-X
Comments
Targeting necroptosis prevents viral-induced lung damage – Yufang Shi, Peishan Li, Jun Zhou and Gerry Melino. https://www.nature.com/articles/s41418-024-01299-1
Relaying gasdermin D to the membrane – Lisa Heinke. https://www.nature.com/articles/s41580-024-00737-9
Apoptosis and cell death 