Cytotoxicity, efferocytosis
NINJ1 mediates plasma membrane rupture by cutting and releasing membrane disks – Liron David, Jazlyn P. Borges, L. Robert Hollingsworth, Allen Volchuk, Isabelle Jansen, Evelyn Garlick, Benjamin E. Steinberg, Hao Wu. https://www.cell.com/cell/abstract/S0092-8674(24)00300-3
Redistribution of the glycocalyx exposes phagocytic determinants on apoptotic cells – Trieu Le, Iuliia Ferling, Lanhui Qiu, Clement Nabaile, Leonardo Assunção, Calvin D. Roskelley, Sergio Grinstein, Spencer A. Freeman. https://www.cell.com/developmental-cell/abstract/S1534-5807(24)00040-6
epHero – a tandem-fluorescent probe to track the fate of apoptotic cells during efferocytosis – Sanjna Singh, Julien Bensalem, Leanne K. Hein, Aaron Casey, Ville-Petteri Mäkinen and Timothy J. Sargeant. https://www.nature.com/articles/s41420-024-01952-1
Death receptors
IRE1 RNase controls CD95-mediated cell death – Diana Pelizzari-Raymundo, Victoria Maltret, Manon Nivet, Raphael Pineau, Alexandra Papaioannou, Xingchen Zhou, Flavie Caradec, Sophie Martin, Matthieu Le Gallo, Tony Avril, Eric Chevet, and Elodie Lafont. https://www.embopress.org/doi/full/10.1038/s44319-024-00095-9
Biallelic human SHARPIN loss of function induces autoinflammation and immunodeficiency – Hirotsugu Oda, Kalpana Manthiram, Pallavi Pimpale Chavan, Eva Rieser, Önay Veli, Öykü Kaya, Charles Rauch, Shuichiro Nakabo, Hye Sun Kuehn, Mariël Swart, Yanli Wang, Nisa Ilgim Çelik, Anne Molitor, Vahid Ziaee, Nasim Movahedi, Mohammad Shahrooei, Nima Parvaneh, Nasrin Alipour-olyei, Raphael Carapito, Qin Xu, Silvia Preite, David B. Beck, Jae Jin Chae, Michele Nehrebecky, Amanda K. Ombrello, Patrycja Hoffmann, Tina Romeo, Natalie T. Deuitch, Brynja Matthíasardóttir, James Mullikin, Hirsh Komarow, Jennifer Stoddard, Julie Niemela, Kerry Dobbs, Colin L. Sweeney, Holly Anderton, Kate E. Lawlor, Hiroyuki Yoshitomi, Dan Yang, Manfred Boehm, Jeremy Davis, Pamela Mudd, Davide Randazzo, Wanxia Li Tsai, Massimo Gadina, Mariana J. Kaplan, Junya Toguchida, Christian T. Mayer, Sergio D. Rosenzweig, Luigi D. Notarangelo, Kazuhiro Iwai, John Silke, Pamela L. Schwartzberg, Bertrand Boisson, Jean-Laurent Casanova, Seiamak Bahram, Anand Prahalad Rao, Nieves Peltzer, Henning Walczak, Najoua Lalaoui, Ivona Aksentijevich and Daniel L. Kastner. https://www.nature.com/articles/s41590-024-01817-w
Caspases and gasdermins
A bacterial toxin co-opts caspase-3 to disable active gasdermin D and limit macrophage pyroptosis – Skylar S. Wright, Chengliang Wang, Atri Ta, Morena S. Havira, Jianbin Ruan, Vijay A. Rathinam, Sivapriya Kailasan Vanaja. https://www.cell.com/cell-reports/fulltext/S2211-1247(24)00332-2
African swine fever virus infection regulates pyroptosis by cleaving gasdermin A (GSDMA) via active caspase-3 and caspase-4 – Shuai Li, Jie Song, jia Liu, Shijun Zhou, Gaihong Zhao, Tingting Li, Li Huang, Jiangnan Li, Changjiang Weng. https://www.jbc.org/article/S0021-9258(24)01808-8
Caspase 8 deletion causes infection/inflammation-induced bone marrow failure and MDS-like disease in mice – Shanhui Liu, Kanak Joshi, Lei Zhang, Wenyan Li, Ryan Mack, Austin Runde, Patrick A. Hagen, Kevin Barton, Peter Breslin, Hong-Long Ji, Ameet R. Kini, Zhiping Wang and Jiwang Zhang. https://www.nature.com/articles/s41419-024-06660-3
Pyroptosis
The palmitoylation of gasdermin D directs its membrane translocation and pore formation during pyroptosis – Arumugam Balasubramanian, Alan Y Hsu, Laxman Ghimire, Muhammad Tahir, Pascal Devant, Pietro Fontana, Gang Du, Xing Liu, Dang Fabin, Hiroto Kambara, Xuemei Xie, Fei Liu, Tomoya Hasegawa, Rong Xu, Hongbo Yu, Mei Chen, Steven Kolakowski, Sunia Trauger, Martin Røssel Larsen, Wenyi Wei, Hao Wu, Jonathan C Kagan, Judy Lieberman, Hongbo R Luo. https://www.science.org/doi/10.1126/sciimmunol.adn1452
Pyroptosis activates conventional type I dendritic cells to mediate the priming of highly functional anticancer T cells – Jordon M Inkol, Michael J Westerveld, Shayla G Verburg, Scott R Walsh, Jodi Morrison, Karen L Mossman, Sarah M Worfolk, Kaslyn LF Kallio, Noah J Phippen, Rebecca Burchett, Yonghong Wan, Jonathan Bramson and Samuel T Workenhe. https://jitc.bmj.com/content/12/4/e006781
Involution of brown adipose tissue through a Syntaxin 4 dependent pyroptosis pathway – Xiaofan Yu, Gabrielle Benitez, Peter Tszki Wei, Sofia V. Krylova, Ziyi Song, Li Liu, Meifan Zhang, Alus M. Xiaoli, Henna Wei, Fenfen Chen, Simone Sidoli, Fajun Yang, Kosaku Shinoda, Jeffrey E. Pessin and Daorong Feng. https://www.nature.com/articles/s41467-024-46944-y
Necroptosis
Defective prelamin A processing promotes unconventional necroptosis driven by nuclear RIPK1 – Yuanxin Yang, Jian Zhang, Mingming lv, Na Cui, Bing Shan, Qi Sun, Lingjie Yan, Mengmeng Zhang, Chengyu Zou, Junying Yuan and Daichao Xu. https://www.nature.com/articles/s41556-024-01374-2
RIPK3 deficiency blocks R-2-hydroxyglutarate-induced necroptosis in IDH-mutated AML cells – Zhu S, Luo Y, Li K, Mei C, Wang Y, Jiang L, Wang W, Zhang Q, Yang W, Lang W, Zhou X, Wang L, Ren Y, Ma L, Ye L, Huang X, Chen J, Sun J, Tong H. https://www.science.org/doi/10.1126/sciadv.adi1782
Ferroptosis
NINJ1 induces plasma membrane rupture and release of damage-associated molecular pattern molecules during ferroptosis – Saray Ramos, Ella Hartenian, José Carlos Santos, Philipp Walch, and Petr Broz. https://www.embopress.org/doi/full/10.1038/s44318-024-00055-y
PHLDA2-mediated phosphatidic acid peroxidation triggers a distinct ferroptotic response during tumor suppression – Xin Yang, Zhe Wang, Svetlana N. Samovich, Alexander A. Kapralov, Andrew A. Amoscato, Vladimir A. Tyurin, Haider H. Dar, Zhiming Li, Shoufu Duan, Ning Kon, Delin Chen, Benjamin Tycko, Zhiguo Zhang, Xuejun Jiang, Hülya Bayir, Brent R. Stockwell, Valerian E. Kagan, Wei Gu. https://www.cell.com/cell-metabolism/abstract/S1550-4131(24)00005-6
Bcl-2 family proteins
TCEB3 initiates ovarian cancer apoptosis by mediating ubiquitination and degradation of MCL-1 – Ying Cai, Yun Li, Yingjie Xu, Wen Yang, Masha Huang. https://faseb.onlinelibrary.wiley.com/doi/abs/10.1096/fj.202400249RR
Endogenous BAX and BAK form mosaic rings of variable size and composition on apoptotic mitochondria – Sarah V. Schweighofer, Daniel C. Jans, Jan Keller-Findeisen, Anne Folmeg, Peter Ilgen, Mark Bates and Stefan Jakobs. https://www.nature.com/articles/s41418-024-01273-x
BH3 profiling as pharmacodynamic biomarker for the activity of BH3 mimetics – Rongqing Aaron Pan, Youzhen Wang, Shumei Qiu, Mariana Villalobos-Ortiz, Jeremy Ryan, Erick Morris, Ensar Halilovic, Anthony Letai. https://haematologica.org/article/view/haematol.2023.283060
AMPK inhibition sensitizes acute leukemia cells to BH3 mimetic-induced cell death – Jia Jia, Wenbo Ji, Antoine N. Saliba, Clifford M. Csizmar, Kaiqin Ye, Lei Hu, Kevin L. Peterson, Paula A. Schneider, X. Wei Meng, Annapoorna Venkatachalam, Mrinal M. Patnaik, Jonathan A. Webster, B. Douglas Smith, Gabriel Ghiaur, Xinyan Wu, Jun Zhong, Akhilesh Pandey, Karen S. Flatten, Qingmei Deng, Hongzhi Wang, Scott H. Kaufmann and Haiming Dai. https://www.nature.com/articles/s41418-024-01283-9
Phenotyping of cancer-associated somatic mutations in the BCL2 transmembrane domain – Diego Leiva, Estefanía Lucendo, Alicia Belén García-Jareño, Mónica Sancho and Mar Orzáez. https://www.nature.com/articles/s41389-024-00516-3
Miscellanous
Identification of a novel form of caspase-independent cell death triggered by BH3-mimetics in diffuse large B-cell lymphoma cell lines – Nahide Yildirim, Lakshmi Sarojam, Victoria M. Smith, Nadja M. Pieper, Marius Anders, Ross A. Jackson, Dominik C. Fuhrmann, Vinzenz Särchen, Daniela Brücher, Andreas Weigert, Martin J. S. Dyer and Meike Vogler. https://www.nature.com/articles/s41419-024-06652-3
The broad impact of cell death genes on the human disease phenome – Abigail L. Rich, Phillip Lin, Eric R. Gamazon and Sandra S. Zinkel. https://www.nature.com/articles/s41419-024-06632-7
Reviews
Immunogenic cell death in cancer: targeting necroptosis to induce antitumour immunity – Pascal Meier, Arnaud J. Legrand, Dieter Adam and John Silke. https://www.nature.com/articles/s41568-024-00674-x
A guide to cell death pathways – Junying Yuan and Dimitry Ofengeim. https://www.nature.com/articles/s41418-024-01271-z
TNF-Related Apoptosis-Inducing Ligand: Non-Apoptotic Signalling – Abderrahmane Guerrache, Olivier Micheau. https://www.mdpi.com/2073-4409/13/6/521
Exploring Ferroptosis-Inducing Therapies for Cancer Treatment: Challenges and Opportunities – Guang Lei, Boyi Gan. https://aacrjournals.org/cancerres/article-abstract/84/7/961/742047
Cellular senescence: Neither irreversible nor reversible – Maurice Reimann; Soyoung Lee, Clemens A. Schmitt. https://rupress.org/jem/article/221/4/e20232136/276573
Disulfidptosis: disulfide stress–induced cell death – Xiaoguang Liu, Li Zhuang, Boyi Gan. https://www.cell.com/trends/cell-biology/abstract/S0962-8924(23)00141-1
Comments
Roadmap for the next decade of plant programmed cell death research – Joanna Kacprzyk, Rory Burke, Laia Armengot, Marianna Coppola, Sophie B Tattrie, Hannah Vahldick, Diane C Bassham, Maurice Bosch, Nicholas J B Brereton, Jean-Luc Cacas, Núria S Coll, Patrick Gallois, Kazuyuki Kuchitsu, Moritz K Nowack, Hilary J Rogers, Frank Van Breusegem, Arunika H L A N Gunawardena, Paul F McCabe. https://nph.onlinelibrary.wiley.com/doi/10.1111/nph.19709
RIPK1 and necroptosis role in premature ageing – Panxue Wang and John Silke. https://www.nature.com/articles/s41556-024-01390-2
No need to “sugar coat”: Removing glycocalyx on apoptotic blebs promotes phagocytosis – Shannon M. Kelley, Kodi S. Ravichandran. https://www.cell.com/developmental-cell/abstract/S1534-5807(24)00147-3
Diverse functions of cytochrome c in cell death and disease – Zhuan Zhou, Tasnim Arroum, Xu Luo, Rui Kang, Yong J. Lee, Daolin Tang, Maik Hüttemann and Xinxin Song. https://www.nature.com/articles/s41418-024-01284-8
Nude blebs expose cells to phagocytes – ANNALISA M. VANHOOK. https://www.science.org/doi/10.1126/scisignal.adq0353
Human SHARPIN deficiency is linked to inborn errors of cell death. https://www.nature.com/articles/s41590-024-01838-5
Gordon Conference – July 28 to August 2
Chaired by Pascal D. Meier and Ana J. Garcia-Saez
Apoptosis and cell death 