Necroptosis

cris

ApoList – November 2021

Caspases and IAPs

Caspase-2 regulates S-phase cell cycle events to protect from DNA damage accumulation independent of apoptosis – Ashley G. Boice, Karla E. Lopez, Raj K. Pandita, Melissa J. Parsons, Chloe I. Charendoff, Vijay Charaka, Alexandre F. Carisey, Tej K. Pandita and Lisa Bouchier-Hayes. https://www.nature.com/articles/s41388-021-02085-w
XIAP restrains TNF-driven intestinal inflammation and dysbiosis by promoting innate immune responses of Paneth and dendritic cells – Adam Wahida, Madeleine Müller, Andreas Hiergeist, Bastian Popper, Katja Steiger, Caterina Branca, Markus Tschurtschenthaler, Thomas Engleitner, Sainitin Donakonda, Jordy De Coninck, Rupert Öllinger, Marie K. Pfautsch, Nicole Müller, Miguel Silva, Sinem Usluer, Erik Thiele Oberg, Jan P. Böttcher, Nicole Pfarr, Martina Anton, Julia B. Slotta-Huspenina, Andreas G. Nerlich, Tobias Madl, Marijana Basic, André Bleich, Geert Berx, Jürgen Ruland, Percy A. Knolle, Roland Rad, Timon E. Adolph, Peter Vandenabeele, Hirokazu Kanegane, André Gessner, Philipp J. Jost, Monica Yabal. https://www.science.org/doi/full/10.1126/sciimmunol.abf7235
Deficiency in X-linked inhibitor of apoptosis protein promotes susceptibility to microbial triggers of intestinal inflammation – Anne Strigli, Shreya Gopalakrishnan, Yvonne Zeissig, Marijana Basic, Jun Wang, Tobias Schwerd, Shauni Doms, Kenneth Peuker, Jelka Hartwig, Jürgen Harder, Pia Hönscheid, Philipp Arnold, Thomas Kurth, Fabian Rost, Britt-Sabina Petersen, Michael Forster, Andre Franke, Judith R. Kelsen, Meino Rohlfs, Christoph Klein, Aleixo M. Muise, Neil Warner, Ryusuke Nambu, Julia Mayerle, Helga-Paula Török, Andreas Linkermann, Michael H. Muders, Gustavo B. Baretton, Jochen Hampe, Daniela E. Aust, John F. Baines, André Bleich, Sebastian Zeissig. https://www.science.org/doi/full/10.1126/sciimmunol.abf7473
SMAC/Diablo controls proliferation of cancer cells by regulating phosphatidylethanolamine synthesis – Swaroop Kumar Pandey, Avijit Paul, Anna Shteinfer-Kuzmine, Ran Zalk, Uwe Bunz, Varda Shoshan-Barmatz. https://febs.onlinelibrary.wiley.com/doi/full/10.1002/1878-0261.12959

Efferocytosis, entosis, cell-cell

Apoptotic stress-induced FGF signalling promotes non-cell autonomous resistance to cell death – Florian J. Bock, Egor Sedov, Elle Koren, Anna L. Koessinger, Catherine Cloix, Désirée Zerbst, Dimitris Athineos, Jayanthi Anand, Kirsteen J. Campbell, Karen Blyth, Yaron Fuchs and Stephen W. G. Tait. https://www.nature.com/articles/s41467-021-26613-0
TRAIL signaling promotes entosis in colorectal cancer – Emir Bozkurt; Heiko Düssmann; Manuela Salvucci; Brenton L. Cavanagh ; Sandra Van Schaeybroeck; Daniel B. Longley; Seamus J. Martin; Jochen H.M. Prehn. https://rupress.org/jcb/article-abstract/220/11/e202010030/212649
Human intestinal and circulating invariant natural killer T cells are cytotoxic against colorectal cancer cells via the perforin–granzyme pathway – Angélica Díaz-Basabe, Claudia Burrello, Georgia Lattanzi, Fiorenzo Botti, Alberto Carrara, Elisa Cassinotti, Flavio Caprioli, Federica Facciotti. https://febs.onlinelibrary.wiley.com/doi/full/10.1002/1878-0261.13104

Death receptors

HOIP limits anti‐tumor immunity by protecting against combined TNF and IFN‐gamma‐induced apoptosis – Andrew J Freeman, Stephin J Vervoort, Jessica Michie, Kelly M Ramsbottom, John Silke, Conor J Kearney, Jane Oliaro. https://www.embopress.org/doi/abs/10.15252/embr.202153391
A patch of positively charged residues regulates the efficacy of clinical DR5 antibodies in solid tumors – Gururaj Shivange, Tanmoy Mondal, Evan Lyerly, Sanchita Bhatnagar, Charles N. Landen, Shivani Reddy, Jonathan Kim, Britney Doan, Paula Riddle, Jogender Tushir-Singh. https://www.cell.com/cell-reports/fulltext/S2211-1247(21)01430-3
A comprehensive interaction study provides a potential domain interaction network of human death domain superfamily proteins – Wei Zhou, Naoe Kaneko, Tomoya Nakagita, Hiroyuki Takeda and Junya Masumoto. https://www.nature.com/articles/s41418-021-00796-x
TRAIL/DR5 pathway promotes AKT phosphorylation, skeletal muscle differentiation, and glucose uptake – Barbara Toffoli, Federica Tonon, Veronica Tisato, Giorgio Zauli, Paola Secchiero, Bruno Fabris and Stella Bernardi. https://www.nature.com/articles/s41419-021-04383-3

Necroptosis, RIP kinases, MLKL

Oligomerization‐driven MLKL ubiquitylation antagonizes necroptosis – Zikou Liu, Laura F Dagley, Kristy Shield-Artin, Samuel N Young, Aleksandra Bankovacki, Xiangyi Wang, Michelle Tang, Jason Howitt, Che A Stafford, Ueli Nachbur, Cheree Fitzgibbon, Sarah E Garnish, Andrew I Webb, David Komander, James M Murphy, Joanne M Hildebrand, John Silke. https://www.embopress.org/doi/abs/10.15252/embj.2019103718
Human RIPK3 maintains MLKL in an inactive conformation prior to cell death by necroptosis – Yanxiang Meng, Katherine A. Davies and James M. Murphy. https://www.nature.com/articles/s41467-021-27032-x
MLKL promotes cellular differentiation in myeloid leukemia by facilitating the release of G-CSF – Xin Wang, Uris Ros, Deepti Agrawal, Eva C. Keller, Julia Slotta-Huspenina, Veronika Dill, Bo Shen, Run Shi, Tobias Herold, Claus Belka, Ritu Mishra, Florian Bassermann, Ana J. Garcia-Saez and Philipp J. Jost. https://www.nature.com/articles/s41418-021-00811-1
Caspase‐9 acts as a regulator of necroptotic cell death – Tamás Molnár, Petra Pallagi, Bálint Tél, Róbert Király, Eszter Csoma, Viktória Jenei, Zsófia Varga, Péter Gogolák, Anne Odile Hueber, Zoltán Máté, Ferenc Erdélyi, Gábor Szabó, Aladár Pettkó-Szandtner, Attila Bácsi, László Virág, József Maléth, Gábor Koncz. https://febs.onlinelibrary.wiley.com/doi/full/10.1111/febs.15898
Quantitative analysis of phosphoproteome in necroptosis reveals a role of TRIM28 phosphorylation in promoting necroptosis-induced cytokine production – Rui Zu, Zhen Yu, Jing Zhao, Xiaojuan Lu, Wei Liang, Le Sun, Chenfang Si, Kezhou Zhu, Tian Zhang, Ganquan Li, Mengmeng Zhang, Yaoyang Zhang, Nan Liu, Junying Yuan and Bing Shan. https://www.nature.com/articles/s41419-021-04290-7
Genetic inhibition of RIPK3 ameliorates functional outcome in controlled cortical impact independent of necroptosis – Limin Wu, Joon Yong Chung, Tian Cao, Gina Jin, William J. Edmiston III, Suzanne Hickman, Emily S. Levy, Jordyn A. Whalen, Eliza Sophie LaRovere Abrams, Alexei Degterev, Eng H. Lo, Lorenzo Tozzi, David L. Kaplan, Joseph El Khoury and Michael J. Whalen. https://www.nature.com/articles/s41419-021-04333-z
Proteomic analysis of necroptotic extracellular vesicles – Inbar Shlomovitz, Ziv Erlich, Gali Arad, Liat Edry-Botzer, Sefi Zargarian, Hadar Cohen, Tal Manko, Yifat Ofir-Birin, Tomer Cooks, Neta Regev-Rudzki and Motti Gerlic. https://www.nature.com/articles/s41419-021-04317-z

Reviews

Molecular mechanisms and functions of pyroptosis in inflammation and antitumor immunity – Junwei Hou, Jung-Mao Hsu, Mien-Chie Hung. https://www.cell.com/molecular-cell/fulltext/S1097-2765(21)00737-1
Soluble CD95L in cancers and chronic inflammatory disorders, a new therapeutic target? – Keerthi Kurma, Andrea Boizard-Moracchini, Gael Galli, Mickael Jean, Pierre Vacher, Patrick Blanco, Patrick Legembre. https://www.sciencedirect.com/science/article/abs/pii/S0304419X21000937
First we eat, then we do everything else: The dynamic metabolic regulation of efferocytosis – Alissa Trzeciak, Ya-Ting Wang, Justin Shaun Arnold Perry. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(21)00364-8
Apoptotic cell-derived metabolites in efferocytosis-mediated resolution of inflammation – Yiwei Mao. https://www.sciencedirect.com/science/article/abs/pii/S1359610121000745
Dying cells fan the flames of inflammation – Kim Newton, Vishva M. Dixit, Nobuhiko Kayagaki. https://www.science.org/doi/10.1126/science.abi5934#.YaAPliOd4NI

Comments

Cell death leaves a new TRAIL – Michael Overholtzer. https://rupress.org/jcb/article/220/11/e202109018/212699
In Conversation with Tony Letai – Eleni Skourti, Anthony Letai. https://febs.onlinelibrary.wiley.com/doi/full/10.1111/febs.16229
Editor Profile: Eli Arama. https://febs.onlinelibrary.wiley.com/doi/full/10.1111/febs.15902
Bcl-xL and IP3R interaction: Intimate relationship with an uncertain outcome – Nikolay Popgeorgieva, Germain Gillet. https://www.sciencedirect.com/science/article/abs/pii/S0143416021001585

Bcl-2 family proteins

Bcl-xL acts as an inhibitor of IP3R channels, thereby antagonizing Ca2+-driven apoptosis – Nicolas Rosa, Hristina Ivanova, Larry E. Wagner 2nd, Justin Kale, Rita La Rovere, Kirsten Welkenhuyzen, Nikolaos Louros, Spyridoula Karamanou, Victoria Shabardina, Irma Lemmens, Elien Vandermarliere, Kozo Hamada, Hideaki Ando, Frederic Rousseau, Joost Schymkowitz, Jan Tavernier, Katsuhiko Mikoshiba, Anastassios Economou, David W. Andrews, Jan B. Parys, David I. Yule and Geert Bultynck. https://www.nature.com/articles/s41418-021-00894-w
BH3-only proteins Puma and Beclin1 regulate autophagic death in neurons in response to Amyloid-β – Akash Saha, Suraiya Saleem, Paidi Ramesh Kumar and Subhas C. Biswas. https://www.nature.com/articles/s41420-021-00748-x
The BAX-binding protein MOAP1 associates with LC3 and promotes closure of the phagophore – Hao-Chun Chang, Ran N. Tao, Chong Teik Tan, Ya Jun Wu, Boon Huat Bay and Victor C. Yu. https://www.tandfonline.com/doi/full/10.1080/15548627.2021.1896157
Venetoclax imparts distinct cell death sensitivity and adaptivity patterns in T cells – Lindsey M. Ludwig, Katrina M. Hawley, David B. Banks, Anika T. Thomas-Toth, Bruce R. Blazar, Megan E. McNerney, Joel D. Leverson and James L. LaBelle. https://www.nature.com/articles/s41419-021-04285-4
Development of a BCL-xL and BCL-2 dual degrader with improved anti-leukemic activity – Dongwen Lv, Pratik Pal, Xingui Liu, Yannan Jia, Dinesh Thummuri, Peiyi Zhang, Wanyi Hu, Jing Pei, Qi Zhang, Shuo Zhou, Sajid Khan, Xuan Zhang, Nan Hua, Qingping Yang, Sebastian Arango, Weizhou Zhang, Digant Nayak, Shaun K. Olsen, Susan T. Weintraub, Robert Hromas, Marina Konopleva, Yaxia Yuan, Guangrong Zheng and Daohong Zhou. https://www.nature.com/articles/s41467-021-27210-x
Paradoxical implication of BAX/BAK in the persistence of tetraploid cells – Jiayin Deng, Lucía G. Gutiérrez, Gautier Stoll, Omar Motiño, Isabelle Martins, Lucía Núñez, José Manuel Bravo-San Pedro, Juliette Humeau, Chloé Bordenave, Juncheng Pan, Hélène Fohrer-Ting, Sylvie Souquere, Gerard Pierron, Claudio Hetz, Carlos Villalobos, Guido Kroemer and Laura Senovilla. https://www.nature.com/articles/s41419-021-04321-3
UBQLN4 is an ATM substrate that stabilizes the anti‐apoptotic proteins BCL2A1 and BCL2L10 in mesothelioma – Fang Liu, RunSang Pan, HongYu Ding, LiLing Gu, Yun Yang, ChuanYin Li, YongJie Xu, Ronggui Hu, Hui Chen, XiangYan Zhang, YingJie Nie. https://febs.onlinelibrary.wiley.com/doi/full/10.1002/1878-0261.13058
BAX mitochondrial integration is regulated allosterically by its α1−α2 loop – Michael A. Dengler, Leonie Gibson and Jerry M. Adams. https://www.nature.com/articles/s41418-021-00815-x

Pyroptosis

Gasdermin D mediates host cell death bu not interleukin-1β secretion in Mycobacterium tuberculosis-infected macrophages – Sebastian J. Theobald, Jessica Gräb, Melanie Fritsch, Isabelle Suárez, Hannah S. Eisfeld, Sandra Winter, Maximilian Koch, Christoph Hölscher, Manolis Pasparakis, Hamid Kashkar and Jan Rybniker. https://www.nature.com/articles/s41420-021-00716-5

cris

ApoList – March 2020

Research is important. Keep strong everyone

 

Death receptors

TRAIL Receptors Serve as Stress-Associated Molecular Patterns to Promote ER-Stress-Induced Inflammation – Graeme P. Sullivan, Hazel O’Connor, Conor M. Henry, Pavel Davidovich, Danielle M. Clancy, Matthew L. Albert, Sean P. Cullen, Seamus J. Martin. https://www.cell.com/developmental-cell/fulltext/S1534-5807(20)30063-0

A20 Promotes Ripoptosome Formation and TNF-Induced Apoptosis via cIAPs Regulation and NIK Stabilization in Keratinocytes – Maria Feoktistova, Roman Makarov, Sihem Brenji, Anne T. Schneider, Guido J. Hooiveld, Tom Luedde, Martin Leverkus, Amir S. Yazdi and Diana Panayotova-Dimitrova. https://www.mdpi.com/2073-4409/9/2/351

Targeting the Extrinsic Pathway of Hepatocyte Apoptosis Promotes Clearance of Plasmodium Liver Infection – Gregor Ebert, Sash Lopaticki, Matthew T. O’Neill, Ryan W.J. Steel, Marcel Doerflinger, Pravin Rajasekaran, Annie S.P. Yang, Sara Erickson, Lisa Ioannidis, Philip Arandjelovic, Liana Mackiewicz, Cody Allison, John Silke, Marc Pellegrini, Justin A. Boddey. https://www.cell.com/cell-reports/fulltext/S2211-1247(20)30346-6

Caspases and cFLIP

Cancer Cells Employ Nuclear Caspase-8 to Overcome the p53-Dependent G2/M Checkpoint through Cleavage of USP28 – Ines Müller, Elwira Strozyk, Sebastian Schindler, Stefan Beissert, Htoo Zarni Oo, Thomas Sauter, Philippe Lucarelli, Sebastian Raeth, Angelika Hausser, Nader Al Nakouzi, Ladan Fazli, Martin E. Gleave, He Liu, Hans-Uwe Simon, Henning Walczak, Douglas R. Green, Jiri Bartek, Mads Daugaard, Dagmar Kulms. https://www.cell.com/molecular-cell/fulltext/S1097-2765(19)30953-0

Cross-regulation between LUBAC and caspase-1 modulates cell death and inflammation – Todd Douglas and Maya Saleh. http://www.jbc.org/content/early/2020/03/02/jbc.RA119.011622.abstract

Gastermins and pyroptosis

Gasdermin E suppresses tumour growth by activating anti-tumour immunity – Zhibin Zhang, Ying Zhang, Shiyu Xia, Qing Kong, Shunying Li, Xing Liu, Caroline Junqueira, Karla F. Meza-Sosa, Temy Mo Yin Mok, James Ansara, Satyaki Sengupta, Yandan Yao, Hao Wu and Judy Lieberman. https://www.nature.com/articles/s41586-020-2071-9

cFLIPL protects macrophages from LPS-induced pyroptosis via inhibition of complex II formation – Hayley I. Muendlein, David Jetton, Wilson M. Connolly, Keith P. Eidell, Zoie Magri, Irina Smirnova, Alexander Poltorak. https://science.sciencemag.org/content/367/6484/1379

A bioorthogonal system reveals antitumour immune function of pyroptosis – Qinyang Wang, Yupeng Wang, Jingjin Ding, Chunhong Wang, Xuehan Zhou, Wenqing Gao, Huanwei Huang, Feng Shao and Zhibo Liu. https://www.nature.com/articles/s41586-020-2079-1

Structural Mechanism for GSDMD Targeting by Autoprocessed Caspases in Pyroptosis – Kun Wang, Qi Sun, Xiu Zhong, Mengxue Zeng, Huan Zeng, Xuyan Shi, Zilin Li, Yupeng Wang, Qiang Zhao, Feng Shao, Jingjin Ding. https://www.cell.com/cell/fulltext/S0092-8674(20)30146-X

Mitochondrial GSDMD Pores DAMPen Pyroptosis – Katherine C. Barnett, Jenny P.-Y. Ting. https://www.cell.com/immunity/fulltext/S1074-7613(20)30083-2

mtDNA Activates cGAS Signaling and Suppresses the YAP-Mediated Endothçelial Cell Proliferation Program to Promote Inflammatory Injury – Long Shuang Huang, Zhigang Hong, Wei Wu, Shiqin Xiong, Ming Zhong, Xiaopei Gao, Jalees Rehman, Asrar B. Malik. https://www.cell.com/immunity/fulltext/S1074-7613(20)30083-2

A bioorthogonal system reveals antitumour immune function of pyroptosis – Qinyang Wang, Yupeng Wang, Jingjin Ding, Chunhong Wang, Xuehan Zhou, Wenqing Gao, Huanwei Huang, Feng Shao and Zhibo Liu. https://www.nature.com/articles/s41586-020-2079-1

Bcl-2 family proteins

A small-molecule allosteric inhibitor of BAX protects against doxorubicin-induced cardiomyopathy – Dulguun Amgalan, Thomas P. Garner, Ryan Pekson, Xiaotong F. Jia, Mounica Yanamandala, Victor Paulino, Felix G. Liang, J. Jose Corbalan, Jaehoon Lee, Yun Chen, George S. Karagiannis, Luis Rivera Sanchez, Huizhi Liang, Swathi-Rao Narayanagari, Kelly Mitchell, Andrea Lopez, Victoria Margulets, Marco Scarlata, Gaetano Santulli, Aarti Asnani, Randall T. Peterson, Rachel B. Hazan, John S. Condeelis, Maja H. Oktay, Ulrich Steidl, Lorrie A. Kirshenbaum, Evripidis Gavathiotis and Richard N. Kitsis. https://www.nature.com/articles/s43018-020-0039-1

Site-Dependent Cysteine Lipidation Potentiates the Activation of Proapoptotic BAX – Daniel T. Cohen, Thomas E. Wales, Matthew W. McHenry, John R. Engen, Loren D. Walensky. https://www.cell.com/cell-reports/fulltext/S2211-1247(20)30225-4

Low expression of pro-apoptotic proteins Bax, Bak and Smac indicates prolonged progression-free survival in chemotherapy-treated metastatic melanoma – Cristiano Guttà, Arman Rahman, Claudia Aura, Peter Dynoodt, Emilie M. Charles, Elodie Hirschenhahn, Jesuchristopher Joseph, Jasper Wouters, Ciaran de Chaumont, Mairin Rafferty, Madhuri Warren, Joost J. van den Oord, William M. Gallagher and Markus Rehm. https://www.nature.com/articles/s41419-020-2309-3

SFTSV Infection Induces BAK/BAX-Dependent Mitochondrial DNA Release to Trigger NLRP3 Inflammasome Activation – Shufen Li, Hao Li, Yu-Lan Zhang, Qi-Lin Xin, Zhen-Qiong Guan, Xi Chen, Xiao-Ai Zhang, Xiao-Kun Li, Geng-Fu Xiao, Pierre-Yves Lozach, Jun Cui, Wei Liu, Lei-Ke Zhang, Ke Peng. https://www.cell.com/cell-reports/fulltext/S2211-1247(20)30286-2

Combined reduction in the expression of MCL-1 and BCL-2 reduces organismal size in mice – Francine Ke, Graeme I. Lancaster, Stephanie Grabow, Andrew J. Murphy and Andreas Strasser. https://www.nature.com/articles/s41419-020-2376-5

MCL1 is Required for Maintenance of Intestinal Homeostasis and Prevention of Carcinogenesis in Mice – Marc E. Healy, Yannick Boege, Michael C. Hodder, Friederike Böhm, Mohsen Malehmir, Anna-Lena Scherr, Jasna Jetzer, Lap Kwan Chan, Rossella Parrotta, Kurt Jacob, Laure-Alix Clerbaux, Susanne Kreutzer, Andrew Campbell, Ella Gilchrist, Kathryn Gilroy, Ann-Katrin Rodewal , Hanna Honcharova-Biletska, Roman Schimmer, Karelia Vélez, Simone Büeler, Patrizia Cammareri , Gabriela Kalna, Anna S. Wenning, Kathy D. McCoy, Mercedes Gomez de Agüero, Henning Schulze-Bergkamen, Christoph Klose, Kristian Unger, Andrew J. Macpherson , Andreas E. Moor, Bruno Köhler, Owen J. Sanso, Mathias Heikenwalder, Achim Weber. https://www.gastrojournal.org/article/S0016-5085(20)30338-3/fulltext

HUWE1 controls MCL1 stability to unleash AMBRA1-induced mitophagy – Flavie Strappazzon, Anthea Di Rita, Angelo Peschiaroli, Pier Paolo Leoncini, Franco Locatelli, Gerry Melino and Francesco Cecconi. https://www.nature.com/articles/s41418-019-0404-8

MCL1 binding to the reverse BH3 motif of P18INK4C couples cell survival to cell proliferation – Robert H. Whitaker and William J. Placzek. https://www.nature.com/articles/s41419-020-2351-1

MCL1 inhibition is effective against a subset of small-cell lung cancer with high MCL1 and low BCL-XL expression – Yuto Yasuda, Hiroaki Ozasa, Young Hak Kim, Masatoshi Yamazoe, Hitomi Ajimizu, Tomoko Yamamoto Funazo, Takashi Nomizo, Takahiro Tsuji, Hironori Yoshida, Yuichi Sakamori, Naoki Nakajima, Toshi Menju, Akihiko Yoshizawa, Hiroshi Date and Toyohiro Hirai. https://www.nature.com/articles/s41419-020-2379-2

Conformational Switching in Bcl-xL: Enabling Non-Canonic Inhibition of Apoptosis Involves Multiple Intermediates and Lipid Interactions – Victor Vasquez-Montes, Alexander Kyrychenko, Mauricio Vargas-Uribe, Mykola V. Rodnin and Alexey S. Ladokhin. https://www.mdpi.com/2073-4409/9/3/539

Electron transport chain activity is a predictor and target for venetoclax sensitivity in multiple myeloma – Richa Bajpai, Aditi Sharma, Abhinav Achreja, Claudia L. Edgar, Changyong Wei, Arusha A. Siddiqa, Vikas A. Gupta, Shannon M. Matulis, Samuel K. McBrayer, Anjali Mittal, Manali Rupji, Benjamin G. Barwick, Sagar Lonial, Ajay K. Nooka, Lawrence H. Boise, Deepak Nagrath and Mala Shanmugam. https://www.nature.com/articles/s41467-020-15051-z

Necroptosis

Sequential activation of necroptosis and apoptosis cooperates to mediate vascular and neural pathology in stroke – Masanori Gomi Naito, Daichao Xu, Palak Amin, Jinwoo Lee, Huibing Wang, Wanjin Li, Michelle Kelliher, Manolis Pasparakis, and Junying Yuan. https://www.pnas.org/content/117/9/4959.abstract?etoc

Z-nucleic-acid sensing triggers ZBP1-dependent necroptosis and inflammation – Huipeng Jiao, Laurens Wachsmuth, Snehlata Kumari, Robin Schwarzer, Juan Lin, Remzi Onur Eren, Amanda Fisher, Rebecca Lane, George R. Young, George Kassiotis, William J. Kaiser and Manolis Pasparakis. https://www.nature.com/articles/s41586-020-2129-8

Gut stem cell necroptosis by genome instability triggers bowel inflammation – Ruicong Wang, Hongda Li, Jianfeng Wu, Zhi-Yu Cai, Baizhou Li, Hengxiao Ni, Xingfeng Qiu, Hui Chen, Wei Liu, Zhang-Hua Yang, Min Liu, Jin Hu, Yaoji Liang, Ping Lan, Jiahuai Han and Wei Mo. https://www.nature.com/articles/s41586-020-2127-x

Inhibition of keratinocyte necroptosis mediated by RIPK1/RIPK3/MLKL provides a protective effect against psoriatic inflammation – Xiaoru Duan, Xinxin Liu, Nian Liu, Yuqiong Huang, Zilin Jin, Song Zhang, Zhangyin Ming and Hongxiang Chen. https://www.nature.com/articles/s41419-020-2328-0

Necroptosis-blocking compound NBC1 targets heat shock protein 70 to inhibit MLKL polymerization and necroptosis – Andrea N. Johnston, Yuyong Ma, Hua Liu, Shuzhen Liu, Sarah Hanna-Addams, She Chen, Chuo Chen and Zhigao Wang. https://www.pnas.org/content/117/12/6521.abstract?etoc

Influenza Virus Z-RNAs Induce ZBP1-Mediated Necroptosis – Ting Zhang, Chaoran Yin, David F. Boyd, Giovanni Quarato, Justin P. Ingram, Maria Shubina, Katherine B. Ragan, Takumi Ishizuka, Jeremy Chase Crawford, Bart Tummers, Diego A. Rodriguez, Jia Xue, Suraj Peri, William J. Kaiser, Carolina B. López, Yan Xu, Jason W. Upton, Paul G. Thomas, Douglas R. Green, Siddharth Balachandran. https://www.cell.com/cell/fulltext/S0092-8674(20)30227-0

The necroptosis machinery mediates axonal degeneration in a model of Parkinson disease – Maritza Oñate, Alejandra Catenaccio, Natalia Salvadores, Cristian Saquel, Alexis Martinez, Ines Moreno-Gonzalez, Nazaret Gamez, Paulina Soto, Claudio Soto, Claudio Hetz and Felipe A. Court. https://www.nature.com/articles/s41418-019-0408-4

Ferroptosis

Transferrin Receptor Is a Specific Ferroptosis Marker – Huizhong Feng, Kenji Schorpp, Jenny Jin, Carrie E. Yozwiak, Benjamin G. Hoffstrom, Aubrianna M. Decker, Presha Rajbhandari, Michael E. Stokes, Hannah G. Bender, Joleen M. Csuka, Pavan S. Upadhyayula, Peter Canoll, Koji Uchida, Rajesh K. Soni, Kamyar Hadian, Brent R. Stockwell. https://www.cell.com/cell-reports/fulltext/S2211-1247(20)30210-2

Mitochondrial DNA stress triggers autophagy-dependent ferroptotic death – Li C, Zhang Y, Liu J, Kang R, Klionsky DJ, Tang D. https://www.tandfonline.com/doi/full/10.1080/15548627.2020.1739447

Caspase-1 interdomain linker cleavage is required for pyroptosis – Daniel P Ball, Cornelius Y Taabazuing, Andrew R Griswold, Elizabeth L Orth, Sahana D Rao, Ilana B Kotliar, Lauren E Vostal, Darren C Johnson and Daniel A Bachovchin. https://www.life-science-alliance.org/content/3/3/e202000664.abstract

Efferocytosis and cell-cell effects

Metabolites released from apoptotic cells act as tissue messengers – Christopher B. Medina, Parul Mehrotra, Sanja Arandjelovic, Justin S. A. Perry, Yizhan Guo, Sho Morioka, Brady Barron, Scott F. Walk, Bart Ghesquière, Alexander S. Krupnick, Ulrike Lorenz and Kodi S. Ravichandran. https://www.nature.com/articles/s41586-020-2121-3

Macrophage Metabolism of Apoptotic Cell-Derived Arginine Promotes Continual Efferocytosis and Resolution of Injury – Arif Yurdagul Jr., Manikandan Subramanian, Xiaobo Wang, Scott B. Crown, Olga R. Ilkayeva, Lancia Darville, Gopi K. Kolluru, Christina C. Rymond, Brennan D. Gerlach, Ze Zheng, George Kuriakose, Christopher G. Kevil, John M. Koomen, John L. Cleveland, Deborah M. Muoio, Ira Tabas. https://www.sciencedirect.com/science/article/abs/pii/S1550413120300012

Miscellanous

In vivo detection of programmed cell death during mouse heart development – Kristel Martínez-Lagunas, Yoshifumi Yamaguchi, Cora Becker, Caroline Geisen, Marco C. DeRuiter, Masayuki Miura, Bernd K. Fleischmann and Michael Hesse. https://www.nature.com/articles/s41418-019-0426-2

Reviews

Classification and Nomenclature of Metacaspases and Paracaspases: No More Confusion with Caspases – Elena A. Minina, Jens Staal, Vanina E. Alvarez, John A. Berges, Ilana Berman-Frank, Rudi Beyaert, Kay D. Bidle, Frédéric Bornancin, Magali Casanova, Juan J. Cazzulo, Chang Jae Choi, Nuria S. Coll, Vishva M. Dixit, Marko Dolinar, Nicolas Fasel, Christiane Funk, Patrick Gallois, Kris Gevaert, Emilio Gutierrez-Beltran, Stephan Hailfinger, Marina Klemenčič, Eugene V. Koonin, Daniel Krappmann, Anna Linusson, Maurício F.M. Machado, Frank Madeo, Lynn A. Megeney, Panagiotis N. Moschou, Jeremy C. Mottram, Thomas Nyström, Heinz D. Osiewacz, Christopher M. Overall, Kailash C. Pandey, Jürgen Ruland, Guy S. Salvesen, Yigong Shi, Andrei Smertenko, Simon Stael, Jerry Ståhlberg, María Fernanda Suárez, Margot Thome, Hannele Tuominen, Frank Van Breusegem, Renier A.L. van der Hoorn, Assaf Vardi, Boris Zhivotovsky, Eric Lam, Peter V. Bozhkov. https://www.cell.com/molecular-cell/fulltext/S1097-2765(19)30950-5

Investigating Nonapoptotic Cell Death Using Chemical Biology Approaches – David A. Armenta, Scott J. Dixon. https://www.cell.com/cell-chemical-biology/fulltext/S2451-9456(20)30079-9

Ferroptosis: past, present and future – Jie Li, Feng Cao, He-liang Yin, Zi-jian Huang, Zhi-tao Lin, Ning Mao, Bei Sun and Gang Wang. https://www.nature.com/articles/s41419-020-2298-2

Restoring Apoptosis with BH3 Mimetics in Mature B-Cell Malignancies – Maxime Jullien, Patricia Gomez-Bougie, David Chiron and Cyrille Touzeau. https://www.mdpi.com/2073-4409/9/3/717

Comments

Ghostly metabolic messages from dying cells – Douglas R. Green. https://www.nature.com/articles/d41586-020-00641-0

ER Stress Leaves an Inflammatory TRAIL – Alba Roca Portoles, Stephen W.G. Tait. https://www.cell.com/developmental-cell/fulltext/S1534-5807(20)30188-X

Appetite for Arginine: Metabolic Control of Macrophage Hunger – Daniel J. Puleston, Erika L. Pearce. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(20)30064-4

TAMing efferocytosis to fight tumors – Christopher B. Rodell. https://stm.sciencemag.org/content/12/533/eabb0795

Destroying tumors with pyroptosis – John F. Foley. https://stke.sciencemag.org/content/13/624/eabb8244

cris

ApoList – November 2018

http://eepurl.com/cvmBlv

Efferocytosis / Inflammation

The Mitochondrial Apoptotic Effectors BAX/BAK Activate Caspase-3 and -7 to Trigger NLRP3 Inflammasome and Caspase-8 Driven IL-1β Activation – James E. Vince, Dominic De Nardo, Wenqing Gao, Angelina J. Vince, Cathrine Hall, Kate McArthur, Daniel Simpson, Swarna Vijayaraj, Lisa M. Lindqvist, Philippe Bouillet, Mark A. Rizzacasa, Si Ming Man, John Silke, Seth L. Masters, Guillaume Lessene, David C.S. Huang, Daniel H.D. Gray, Benjamin T. Kile, Feng Shao, Kate E. Lawlor. https://www.cell.com/cell-reports/fulltext/S2211-1247(18)31725-X

BAX/BAK-Induced Apoptosis Results in Caspase-8-Dependent IL-1β Maturation in Macrophages – Dhruv Chauhan, Eva Bartok, Moritz M. Gaidt, Florian J. Bock, Jennifer Herrmann, Jens M. Seeger, Petr Broz, Roland Beckmann, Hamid Kashkar, Stephen W.G. Tait, Rolf Müller, Veit Hornung. https://www.cell.com/cell-reports/fulltext/S2211-1247(18)31691-7

Efferocytosis induces a novel SLC program to promote glucose uptake and lactate release – Sho Morioka, Justin S. A. Perry, Michael H. Raymond, Christopher B. Medina, Yunlu Zhu, Liyang Zhao, Vlad Serbulea, Suna Onengut-Gumuscu, Norbert Leitinger, Sarah Kucenas, Jeffrey C. Rathmell, Liza Makowski and Kodi S. Ravichandran. https://www.nature.com/articles/s41586-018-0735-5

Efferocytosis of apoptotic alveolar epithelial cells is sufficient to initiate lung fibrosis – Kevin K. Kim, Megan R. Dotson, Manisha Agarwal, Jibing Yang, Patrick B. Bradley, Natalia Subbotina, John J. Osterholzer and Thomas H. Sisson. https://www.nature.com/articles/s41419-018-1074-z

Pyroptosis / Gasdermin D / Gasdermin E

Caspase-8 induces cleavage of gasdermin D to elicit pyroptosis during Yersinia infection – Joseph Sarhan, Beiyun C. Liu, Hayley I. Muendlein, Peng Li, Rachael Nilson, Amy Y. Tang, Anthony Rongvaux, Stephen C. Bunnell, Feng Shao, Douglas R. Green, and Alexander Poltorak. http://www.pnas.org/content/115/46/E10888?etoc=

Pathogen blockade of TAK1 triggers caspase-8–dependent cleavage of gasdermin D and cell death – Pontus Orning, Dan Weng, Kristian Starheim, Dmitry Ratner, Zachary Best, Bettina Lee, Alexandria Brooks, Shiyu Xia, Hao Wu, Michelle A. Kelliher, Scott B. Berger, Peter J. Gough, John Bertin, Megan M. Proulx, Jon D. Goguen, Nobuhiko Kayagaki, Katherine A. Fitzgerald, Egil Lien. http://science.sciencemag.org/content/362/6418/1064

ESCRT-dependent membrane repair negatively regulates pyroptosis downstream of GSDMD activation – Sebastian Rühl, Kateryna Shkarina, Benjamin Demarco, Rosalie Heilig, José Carlos Santos, Petr Broz. http://science.sciencemag.org/content/362/6417/956

Shiga Toxin/Lipopolysaccharide Activates Caspase-4 and Gasdermin D to Trigger Mitochondrial Reactive Oxygen Species Upstream of the NLRP3 Inflammasome – Jaye M. Platnich, Hyunjae Chung, Arthur Lau, Christina F. Sandall, Adom Bondzi-Simpson, Huey-Miin Chen, Takanori Komada, Aaron C. Trotman-Grant, Jeremy R. Brandelli, Justin Chun, Paul L. Beck, Dana J. Philpott, Stephen E. Girardin, May Ho, Roger P. Johnson, Justin A. MacDonald, Glen D. Armstrong, Daniel A. Muruve. https://www.cell.com/cell-reports/fulltext/S2211-1247(18)31531-6

Molecular Targeted Therapies Elicit Concurrent Apoptotic and GSDME-Dependent Pyroptotic Tumor Cell Death – Haijiao Lu, Shengzhe Zhang, Jie Wu, Minjiang Chen, Mei-Chun Cai, Yujie Fu, Wenfeng Li, Jing Wang, Xiaojing Zhao, Zhuang Yu, Pengfei Ma and Guanglei Zhuang. http://clincancerres.aacrjournals.org/content/24/23/6066

Gasdermin E Does Not Limit Apoptotic Cell Disassembly by Promoting Early Onset of Secondary Necrosis in Jurkat T Cells and THP-1 Monocytes – Rochelle Tixeira, Bo Shi†, Michael A. F. Parkes, Amy L. Hodge, Sarah Caruso, Mark D. Hulett, Amy A. Baxter, Thanh Kha Phan and Ivan K. H. Poon. https://www.frontiersin.org/articles/10.3389/fimmu.2018.02842/full

Death receptors / FLIP

TBK1 and IKKε prevent TNF-induced cell death by RIPK1 phosphorylation – Elodie Lafont, Peter Draber, Eva Rieser, Matthias Reichert, Sebastian Kupka, Diego de Miguel, Helena Draberova, Anne von Mässenhausen, Amandeep Bhamra, Stephen Henderson, Katarzyna Wojdyla, Avigayil Chalk, Silvia Surinova, Andreas Linkermann and Henning Walczak. https://www.nature.com/articles/s41556-018-0229-6

Fas receptor induces apoptosis of synovial bone and cartilage progenitor populations and promotes bone loss in antigen-induced arthritis – Elvira Lazić Mosler, Nina Lukač, Darja Flegar, Martina Fadljević, Igor Radanović, Hrvoje Cvija, Tomislav Kelava, Sanja Ivčević, Alan Šućur, Antonio Markotić, Vedran Katavić, Ana Marušić, Danka Grčević and Nataša Kovačić. https://www.fasebj.org/doi/abs/10.1096/fj.201801426R?ai=ts&ui=ly8&af=T

Cell polarity and adherens junction formation inhibit epithelial Fas cell death receptor signaling – Laurent Gagnoux-Palacios, Hala Awina, Stéphane Audebert, Aurélie Rossin, Magali Mondin, Franck Borgese, Carlota Planas-Botey, Amel Mettouchi, Jean-Paul Borg and Anne-Odile Hueber. http://jcb.rupress.org/content/217/11/3839?etoc

Cytoplasmic FLIP(S) and nuclear FLIP(L) mediate resistance of castrate-resistant prostate cancer to apoptosis induced by IAP antagonists – Christopher McCann, Nyree Crawford, Joanna Majkut, Caitriona Holohan, Chris W. D. Armstrong, Pamela J. Maxwell, Chee Wee Ong, Melissa J. LaBonte, Simon S. McDade, David J. Waugh and Daniel B. Longley. https://www.nature.com/articles/s41419-018-1125-5

Mcl-1

A Novel MCL1 Inhibitor Combined with Venetoclax Rescues Venetoclax-Resistant Acute Myelogenous Leukemia – Haley E. Ramsey, Melissa A. Fischer, Taekyu Lee, Agnieszka E. Gorska, Maria Pia Arrate, Londa Fuller, Kelli L. Boyd, Stephen A. Strickland, John Sensintaffar, Leah J. Hogdal, Gregory D. Ayers, Edward T. Olejniczak, Stephen W. Fesik and Michael R. Savona. http://cancerdiscovery.aacrjournals.org/content/8/12/1566

AMG 176, a Selective MCL1 Inhibitor, Is Effective in Hematologic Cancer Models Alone and in Combination with Established Therapies – Sean Caenepeel, Sean P. Brown, Brian Belmontes, Gordon Moody, Kathleen S. Keegan, Danny Chui, Douglas A. Whittington, Xin Huang, Leszek Poppe, Alan C. Cheng, Mario Cardozo, Jonathan Houze, Yunxiao Li, Brian Lucas, Nick A. Paras, Xianghong Wang, Joshua P. Taygerly, Marc Vimolratana, Manuel Zancanella, Liusheng Zhu, Elaina Cajulis, Tao Osgood, Jan Sun, Leah Damon, Regina K. Egan, Patricia Greninger, Joseph D. McClanaghan, Jianan Gong, Donia Moujalled, Giovanna Pomilio, Pedro Beltran, Cyril H. Benes, Andrew W. Roberts, David C. Huang, Andrew Wei, Jude Canon, Angela Coxon and Paul E. Hughes. http://cancerdiscovery.aacrjournals.org/content/8/12/1582

Exploiting MCL1 Dependency with Combination MEK + MCL1 Inhibitors Leads to Induction of Apoptosis and Tumor Regression in KRAS-Mutant Non–Small Cell Lung Cancer – Varuna Nangia, Faria M. Siddiqui, Sean Caenepeel, Daria Timonina, Samantha J. Bilton, Nicole Phan, Maria Gomez-Caraballo, Hannah L. Archibald, Chendi Li, Cameron Fraser, Diamanda Rigas, Kristof Vajda, Lorin A. Ferris, Michael Lanuti, Cameron D. Wright, Kevin A. Raskin, Daniel P. Cahill, John H. Shin, Colleen Keyes, Lecia V. Sequist, Zofia Piotrowska, Anna F. Farago, Christopher G. Azzoli, Justin F. Gainor, Kristopher A. Sarosiek, Sean P. Brown, Angela Coxon, Cyril H. Benes, Paul E. Hughes and Aaron N. Hata. http://cancerdiscovery.aacrjournals.org/content/8/12/1598

Increased Synthesis of MCL-1 Protein Underlies Initial Survival of EGFR-Mutant Lung Cancer to EGFR Inhibitors and Provides a Novel Drug Target – Kyung-A Song, Yasuyuki Hosono, Crystal Turner, Sheeba Jacob, Timothy L. Lochmann, Yoshiko Murakami, Neha U. Patel, Jungoh Ham, Bin Hu, Krista M. Powell, Colin M. Coon, Brad E. Windle, Yuko Oya, Jennifer E. Koblinski, Hisashi Harada, Joel D. Leverson, Andrew J. Souers, Aaron N. Hata, Sosipatros Boikos, Yasushi Yatabe, Hiromichi Ebi and Anthony C. Faber. http://clincancerres.aacrjournals.org/content/24/22/5658

Survival of midbrain dopamine neurons depends on the Bcl2 factor Mcl1 – Edward J. Robinson, Sebastian P. Aguiar, Willemieke M. Kouwenhoven, Dorinde S. Starmans, Lars von Oerthel et al. https://www.nature.com/articles/s41420-018-0125-7

Other Bcl-2 family proteins

VDAC2 enables BAX to mediate apoptosis and limit tumor development – Hui San Chin, Mark X. Li, Iris K. L. Tan, Robert L. Ninnis, Boris Reljic, Kristen Scicluna, Laura F. Dagley, Jarrod J. Sandow, Gemma L. Kelly, Andre L. Samson, Stephane Chappaz, Seong L. Khaw, Catherine Chang, Andrew Morokoff, Kerstin Brinkmann, Andrew Webb, Colin Hockings, Cathrine M. Hall, Andrew J. Kueh, Michael T. Ryan, Ruth M. Kluck, Philippe Bouillet, Marco J. Herold, Daniel H. D. Gray, David C. S. Huang, Mark F. van Delft and Grant Dewson. https://www.nature.com/articles/s41467-018-07309-4

Mannose impairs tumour growth and enhances chemotherapy – Pablo Sierra Gonzalez, James O’Prey, Simone Cardaci, Valentin J. A. Barthet, Jun-ichi Sakamaki, Florian Beaumatin, Antonia Roseweir, David M. Gay, Gillian Mackay, Gaurav Malviya, Elżbieta Kania, Shona Ritchie, Alice D. Baudot, Barbara Zunino, Agata Mrowinska, Colin Nixon, Darren Ennis, Aoisha Hoyle, David Millan, Iain A. McNeish, Owen J. Sansom, Joanne Edwards and Kevin M. Ryan. https://www.nature.com/articles/s41586-018-0729-3

Venetoclax with azacitidine disrupts energy metabolism and targets leukemia stem cells in patients with acute myeloid leukemia – Daniel A. Pollyea, Brett M. Stevens[…], Craig T. Jordan. https://www.nature.com/articles/s41591-018-0233-1

And the companion paper:
Inhibition of Amino Acid Metabolism Selectively Targets Human Leukemia Stem Cells – Courtney L. Jones, Brett M. Stevens, Angelo D’Alessandro, Julie A. Reisz, Rachel Culp-Hill, Travis Nemkov, Shanshan Pei, Nabilah Khan, Biniam Adane, Haobin Ye, Anna Krug, Dominik Reinhold, Clayton Smith, James DeGregori, Daniel A. Pollyea, Craig T. Jordan. https://www.cell.com/cancer-cell/fulltext/S1535-6108(18)30471-9

Tamoxifen overrides autophagy inhibition in Beclin-1-deficient glioma cells and their resistance to adenovirus-mediated oncolysis via upregulation of PUMA and BAX – Natalya V. Kaverina, Zaira G. Kadagidze, Anton V. Borovjagin, Apollon I. Karseladze, Chung Kwon Kim, Maciej S. Lesniak, Jason Miska, Peng Zhang, Maria A. Baryshnikova, Ting Xiao, David Ornelles, Charles Cobbs, Andrey Khramtsov and Ilya V. Ulasov. https://www.nature.com/articles/s41388-018-0395-9

NOXA genetic amplification or pharmacologic induction primes lymphoma cells to BCL2 inhibitor-induced cell death – Yuxuan Liu, Patrizia Mondello, Tatiana Erazo, Neeta Bala Tannan, Zahra Asgari, Elisa de Stanchina, Gouri Nanjangud, Venkatraman E. Seshan, Shenqiu Wang, Hans-Guido Wendel and Anas Younes. http://www.pnas.org/content/115/47/12034?etoc=

Cytoplasmic pro-apoptotic function of the tumor suppressor p73 is mediated through a modified mode of recognition of the anti-apoptotic regulator Bcl-XL – Mi-Kyung Yoon, Bu-Yeon Kim, Ji-Young Lee, Ji-Hyang Ha, Sung Ah Kim, Dong-Hwa Lee, Min-Sung Lee, Mi-Kyung Lee, Jin Sun Choi, Jin Hwa Cho, Jeong-Hoon Kim, Sunhong Kim, Jaewhan Song, Sung Goo Park, Byoung Chul Park, Kwang-Hee Bae, Sang Un Choi and Seung-Wook Chi. http://www.jbc.org/content/early/2018/11/14/jbc.RA118.003061.abstract

Caspases

Caspases maintain tissue integrity by an apoptosis-independent inhibition of cell migration and invasion – Anna Gorelick-Ashkenazi, Ron Weiss, Lena Sapozhnikov, Anat Florentin, Lama Tarayrah-Ibraheim, Dima Dweik, Keren Yacobi-Sharon and Eli Arama. https://www.nature.com/articles/s41467-018-05204-6

Identification of a novel caspase cleavage site in huntingtin that regulates mutant huntingtin clearance – Dale D. O. Martin, Mandi E. Schmidt, Yen T. Nguyen, Nikola Lazic and Michael R. Hayden. https://www.fasebj.org/doi/abs/10.1096/fj.201701510RRR?ai=ts&ui=ly8&af=T

14‐3‐3 protein masks the nuclear localization sequence of caspase‐2 – Aneta Smidova, Miroslava Alblova, Dana Kalabova, Katarina Psenakova, Michal Rosulek, Petr Herman, Tomas Obsil, Veronika Obsilova. https://febs.onlinelibrary.wiley.com/doi/10.1111/febs.14670

Tri-arginine exosite patch of caspase-6 recruits substrates for hydrolysis – Derek J MacPherson, Caityln L Mills, Mary Jo Ondrechen and Jeanne A. Hardy. http://www.jbc.org/content/early/2018/11/12/jbc.RA118.005914.abstract

p53 accumulation following cytokinesis failure in the absence of caspase-2 (letter) – Yoon Lim, Dylan De Bellis, Loretta Dorstyn and Sharad Kumar. https://www.nature.com/articles/s41418-018-0161-0

microRNA-378 promotes autophagy and inhibits apoptosis in skeletal muscle – Yan Li, Jingjing Jiang, Wei Liu, Hui Wang, Lei Zhao, Shengnan Liu, Peng Li, Shengjie Zhang, Chao Sun, Yuting Wu, Shuxian Yu, Xihua Li, Hui Zhang, Haifeng Qian, Duo Zhang, Feifan Guo, Qiwei Zhai, Qiurong Ding, Li Wang and Hao Ying. http://www.pnas.org/content/115/46/E10849?etoc=

Platelet CD36 signaling through ERK5 promotes caspase-dependent procoagulant activity and fibrin deposition in vivo – Moua Yang, Andaleb Kholmukhamedov, Marie L. Schulte, Brian C. Cooley, Na’il O. Scoggins, Jeremy P. Wood, Scott J. Cameron, Craig N. Morrell, Shawn M. Jobeand Roy L. Silverstein. http://www.bloodadvances.org/content/2/21/2848.abstract?etoc

Necroptosis

Axonal degeneration induced by glutamate excitotoxicity is mediated by necroptosis – Diego E. Hernández, Natalia A. Salvadores, Guillermo Moya-Alvarado, Romina J. Catalán, Francisca C. Bronfman and Felipe A. Court. http://jcs.biologists.org/content/131/22/jcs214684?etoc

Soluble TNF-like weak inducer of apoptosis (TWEAK) enhances poly(I:C)-induced RIPK1-mediated necroptosis – Mohamed A. Anany, Jennifer Kreckel, Simone Füllsack, Alevtina Rosenthal, Christoph Otto, Daniela Siegmund and Harald Wajant. https://www.nature.com/articles/s41419-018-1137-1

hsa-miR-500a-3P alleviates kidney injury by targeting MLKL-mediated necroptosis in renal epithelial cells – Ling Jiang, Xue-Qi Liu, Qiuying Ma, Qin Yang, Li Gao, Hai-Di Li, Jia-Nan Wang, Biao Wei, Jiagen Wen, Jun Li, Yong-Gui Wu and Xiao-Ming Meng. https://www.fasebj.org/doi/abs/10.1096/fj.201801711R?ai=ts&ui=ly8&af=T

Miscellanous

The Proton-Coupled Monocarboxylate Transporter Hermes Is Necessary for Autophagy during Cell Death – Panagiotis D. Velentzas, Lejie Zhang, Gautam Das, Tsun-Kai Chang, Charles Nelson, William R. Kobertz, Eric H. Baehrecke. https://www.cell.com/developmental-cell/fulltext/S1534-5807(18)30744-5

Intracellular transport is accelerated in early apoptotic cells – Bo Li, Shuo-Xing Dou, Jing-Wen Yuan, Yu-Ru Liu, Wei Li, Fangfu Ye, Peng-Ye Wang and Hui Li. http://www.pnas.org.sire.ub.edu/content/115/48/12118?etoc=

The yeast mitochondrial permeability transition is regulated by reactive oxygen species, endogenous Ca2+ and Cpr3, mediating cell death – Yoshiko Kamei, Masami Koushi, Yasunori Aoyama, Rei Asakai. https://www.sciencedirect.com/science/article/pii/S000527281830197X

microRNAs selectively protect hub cells of the germline stem cell niche from apoptosis – Marina Volin, Maayan Zohar-Fux, Oren Gonen, Lilach Porat-Kuperstein and Hila Toledano. http://jcb.rupress.org/content/217/11/3829?etoc

Reviews

FLIP as a therapeutic target in cancer – Luke Humphreys, Margarita Espona‐Fiedler, Daniel B. Longley. https://febs.onlinelibrary.wiley.com/doi/10.1111/febs.14523

Counting on Death – Quantitative aspects of Bcl‐2 family regulation – Annika Hantusch, Markus Rehm, Thomas Brunner. https://febs.onlinelibrary.wiley.com/doi/10.1111/febs.14516

Cell-in-cell phenomena in cancer – Stefano Fais and Michael Overholtzer. https://www.nature.com/articles/s41568-018-0073-9

FADD at the Crossroads between Cancer and Inflammation – Sara Mouasni, Léa Tourneur. https://www.cell.com/trends/immunology/fulltext/S1471-4906(18)30189-3

Hematologic Tumor Cell Resistance to the BCL-2 Inhibitor Venetoclax: A Product of Its Microenvironment? – Joel D. Leverson and Dan Cojocari. https://www.frontiersin.org/articles/10.3389/fonc.2018.00458/full

Dependence receptors – the dark side awakens – Ana‐Maria Negulescu, Patrick Mehlen. https://febs.onlinelibrary.wiley.com/doi/10.1111/febs.14507

Comments

Unleashing Blocked Apoptosis in Cancer Cells: New MCL1 Inhibitors Find Their Groove – Brian Leber, Justin Kale and David W. Andrews. http://cancerdiscovery.aacrjournals.org/content/8/12/1511?

TBK1 and IKKε restrain cell death – Klaus Heger and Vishva M. Dixit. https://www.nature.com/articles/s41556-018-0239-4

Timed degradation of Mcl-1 controls mitotic cell death – Paul R. Clarke, Lindsey A. Allan and Agnieszka Skowyra. https://www.tandfonline.com/doi/full/10.1080/23723556.2018.1516450

Necroptosis is key to axonal degeneration after excitotoxicity. http://jcs.biologists.org/content/131/22/e2202?etoc