ApoList – November 2018

http://eepurl.com/cvmBlv


Efferocytosis / Inflammation


The Mitochondrial Apoptotic Effectors BAX/BAK Activate Caspase-3 and -7 to Trigger NLRP3 Inflammasome and Caspase-8 Driven IL-1β Activation – James E. Vince, Dominic De Nardo, Wenqing Gao, Angelina J. Vince, Cathrine Hall, Kate McArthur, Daniel Simpson, Swarna Vijayaraj, Lisa M. Lindqvist, Philippe Bouillet, Mark A. Rizzacasa, Si Ming Man, John Silke, Seth L. Masters, Guillaume Lessene, David C.S. Huang, Daniel H.D. Gray, Benjamin T. Kile, Feng Shao, Kate E. Lawlor. https://www.cell.com/cell-reports/fulltext/S2211-1247(18)31725-X

BAX/BAK-Induced Apoptosis Results in Caspase-8-Dependent IL-1β Maturation in Macrophages – Dhruv Chauhan, Eva Bartok, Moritz M. Gaidt, Florian J. Bock, Jennifer Herrmann, Jens M. Seeger, Petr Broz, Roland Beckmann, Hamid Kashkar, Stephen W.G. Tait, Rolf Müller, Veit Hornung. https://www.cell.com/cell-reports/fulltext/S2211-1247(18)31691-7

Efferocytosis induces a novel SLC program to promote glucose uptake and lactate release – Sho Morioka, Justin S. A. Perry, Michael H. Raymond, Christopher B. Medina, Yunlu Zhu, Liyang Zhao, Vlad Serbulea, Suna Onengut-Gumuscu, Norbert Leitinger, Sarah Kucenas, Jeffrey C. Rathmell, Liza Makowski and Kodi S. Ravichandran. https://www.nature.com/articles/s41586-018-0735-5

Efferocytosis of apoptotic alveolar epithelial cells is sufficient to initiate lung fibrosis – Kevin K. Kim, Megan R. Dotson, Manisha Agarwal, Jibing Yang, Patrick B. Bradley, Natalia Subbotina, John J. Osterholzer and Thomas H. Sisson. https://www.nature.com/articles/s41419-018-1074-z


Pyroptosis / Gasdermin D / Gasdermin E


Caspase-8 induces cleavage of gasdermin D to elicit pyroptosis during Yersinia infection – Joseph Sarhan, Beiyun C. Liu, Hayley I. Muendlein, Peng Li, Rachael Nilson, Amy Y. Tang, Anthony Rongvaux, Stephen C. Bunnell, Feng Shao, Douglas R. Green, and Alexander Poltorak. http://www.pnas.org/content/115/46/E10888?etoc=

Pathogen blockade of TAK1 triggers caspase-8–dependent cleavage of gasdermin D and cell death – Pontus Orning, Dan Weng, Kristian Starheim, Dmitry Ratner, Zachary Best, Bettina Lee, Alexandria Brooks, Shiyu Xia, Hao Wu, Michelle A. Kelliher, Scott B. Berger, Peter J. Gough, John Bertin, Megan M. Proulx, Jon D. Goguen, Nobuhiko Kayagaki, Katherine A. Fitzgerald, Egil Lien. http://science.sciencemag.org/content/362/6418/1064

ESCRT-dependent membrane repair negatively regulates pyroptosis downstream of GSDMD activation – Sebastian Rühl, Kateryna Shkarina, Benjamin Demarco, Rosalie Heilig, José Carlos Santos, Petr Broz. http://science.sciencemag.org/content/362/6417/956

Shiga Toxin/Lipopolysaccharide Activates Caspase-4 and Gasdermin D to Trigger Mitochondrial Reactive Oxygen Species Upstream of the NLRP3 Inflammasome – Jaye M. Platnich, Hyunjae Chung, Arthur Lau, Christina F. Sandall, Adom Bondzi-Simpson, Huey-Miin Chen, Takanori Komada, Aaron C. Trotman-Grant, Jeremy R. Brandelli, Justin Chun, Paul L. Beck, Dana J. Philpott, Stephen E. Girardin, May Ho, Roger P. Johnson, Justin A. MacDonald, Glen D. Armstrong, Daniel A. Muruve. https://www.cell.com/cell-reports/fulltext/S2211-1247(18)31531-6

Molecular Targeted Therapies Elicit Concurrent Apoptotic and GSDME-Dependent Pyroptotic Tumor Cell Death – Haijiao Lu, Shengzhe Zhang, Jie Wu, Minjiang Chen, Mei-Chun Cai, Yujie Fu, Wenfeng Li, Jing Wang, Xiaojing Zhao, Zhuang Yu, Pengfei Ma and Guanglei Zhuang. http://clincancerres.aacrjournals.org/content/24/23/6066

Gasdermin E Does Not Limit Apoptotic Cell Disassembly by Promoting Early Onset of Secondary Necrosis in Jurkat T Cells and THP-1 Monocytes – Rochelle Tixeira, Bo Shi†, Michael A. F. Parkes, Amy L. Hodge, Sarah Caruso, Mark D. Hulett, Amy A. Baxter, Thanh Kha Phan and Ivan K. H. Poon. https://www.frontiersin.org/articles/10.3389/fimmu.2018.02842/full


Death receptors / FLIP


TBK1 and IKKε prevent TNF-induced cell death by RIPK1 phosphorylation – Elodie Lafont, Peter Draber, Eva Rieser, Matthias Reichert, Sebastian Kupka, Diego de Miguel, Helena Draberova, Anne von Mässenhausen, Amandeep Bhamra, Stephen Henderson, Katarzyna Wojdyla, Avigayil Chalk, Silvia Surinova, Andreas Linkermann and Henning Walczak. https://www.nature.com/articles/s41556-018-0229-6

Fas receptor induces apoptosis of synovial bone and cartilage progenitor populations and promotes bone loss in antigen-induced arthritis – Elvira Lazić Mosler, Nina Lukač, Darja Flegar, Martina Fadljević, Igor Radanović, Hrvoje Cvija, Tomislav Kelava, Sanja Ivčević, Alan Šućur, Antonio Markotić, Vedran Katavić, Ana Marušić, Danka Grčević and Nataša Kovačić. https://www.fasebj.org/doi/abs/10.1096/fj.201801426R?ai=ts&ui=ly8&af=T

Cell polarity and adherens junction formation inhibit epithelial Fas cell death receptor signaling – Laurent Gagnoux-Palacios, Hala Awina, Stéphane Audebert, Aurélie Rossin, Magali Mondin, Franck Borgese, Carlota Planas-Botey, Amel Mettouchi, Jean-Paul Borg and Anne-Odile Hueber. http://jcb.rupress.org/content/217/11/3839?etoc

Cytoplasmic FLIP(S) and nuclear FLIP(L) mediate resistance of castrate-resistant prostate cancer to apoptosis induced by IAP antagonists – Christopher McCann, Nyree Crawford, Joanna Majkut, Caitriona Holohan, Chris W. D. Armstrong, Pamela J. Maxwell, Chee Wee Ong, Melissa J. LaBonte, Simon S. McDade, David J. Waugh and Daniel B. Longley. https://www.nature.com/articles/s41419-018-1125-5


Mcl-1


A Novel MCL1 Inhibitor Combined with Venetoclax Rescues Venetoclax-Resistant Acute Myelogenous Leukemia – Haley E. Ramsey, Melissa A. Fischer, Taekyu Lee, Agnieszka E. Gorska, Maria Pia Arrate, Londa Fuller, Kelli L. Boyd, Stephen A. Strickland, John Sensintaffar, Leah J. Hogdal, Gregory D. Ayers, Edward T. Olejniczak, Stephen W. Fesik and Michael R. Savona. http://cancerdiscovery.aacrjournals.org/content/8/12/1566

AMG 176, a Selective MCL1 Inhibitor, Is Effective in Hematologic Cancer Models Alone and in Combination with Established Therapies – Sean Caenepeel, Sean P. Brown, Brian Belmontes, Gordon Moody, Kathleen S. Keegan, Danny Chui, Douglas A. Whittington, Xin Huang, Leszek Poppe, Alan C. Cheng, Mario Cardozo, Jonathan Houze, Yunxiao Li, Brian Lucas, Nick A. Paras, Xianghong Wang, Joshua P. Taygerly, Marc Vimolratana, Manuel Zancanella, Liusheng Zhu, Elaina Cajulis, Tao Osgood, Jan Sun, Leah Damon, Regina K. Egan, Patricia Greninger, Joseph D. McClanaghan, Jianan Gong, Donia Moujalled, Giovanna Pomilio, Pedro Beltran, Cyril H. Benes, Andrew W. Roberts, David C. Huang, Andrew Wei, Jude Canon, Angela Coxon and Paul E. Hughes. http://cancerdiscovery.aacrjournals.org/content/8/12/1582

Exploiting MCL1 Dependency with Combination MEK + MCL1 Inhibitors Leads to Induction of Apoptosis and Tumor Regression in KRAS-Mutant Non–Small Cell Lung Cancer – Varuna Nangia, Faria M. Siddiqui, Sean Caenepeel, Daria Timonina, Samantha J. Bilton, Nicole Phan, Maria Gomez-Caraballo, Hannah L. Archibald, Chendi Li, Cameron Fraser, Diamanda Rigas, Kristof Vajda, Lorin A. Ferris, Michael Lanuti, Cameron D. Wright, Kevin A. Raskin, Daniel P. Cahill, John H. Shin, Colleen Keyes, Lecia V. Sequist, Zofia Piotrowska, Anna F. Farago, Christopher G. Azzoli, Justin F. Gainor, Kristopher A. Sarosiek, Sean P. Brown, Angela Coxon, Cyril H. Benes, Paul E. Hughes and Aaron N. Hata. http://cancerdiscovery.aacrjournals.org/content/8/12/1598

Increased Synthesis of MCL-1 Protein Underlies Initial Survival of EGFR-Mutant Lung Cancer to EGFR Inhibitors and Provides a Novel Drug Target – Kyung-A Song, Yasuyuki Hosono, Crystal Turner, Sheeba Jacob, Timothy L. Lochmann, Yoshiko Murakami, Neha U. Patel, Jungoh Ham, Bin Hu, Krista M. Powell, Colin M. Coon, Brad E. Windle, Yuko Oya, Jennifer E. Koblinski, Hisashi Harada, Joel D. Leverson, Andrew J. Souers, Aaron N. Hata, Sosipatros Boikos, Yasushi Yatabe, Hiromichi Ebi and Anthony C. Faber. http://clincancerres.aacrjournals.org/content/24/22/5658

Survival of midbrain dopamine neurons depends on the Bcl2 factor Mcl1 – Edward J. Robinson, Sebastian P. Aguiar, Willemieke M. Kouwenhoven, Dorinde S. Starmans, Lars von Oerthel et al. https://www.nature.com/articles/s41420-018-0125-7


Other Bcl-2 family proteins


VDAC2 enables BAX to mediate apoptosis and limit tumor development – Hui San Chin, Mark X. Li, Iris K. L. Tan, Robert L. Ninnis, Boris Reljic, Kristen Scicluna, Laura F. Dagley, Jarrod J. Sandow, Gemma L. Kelly, Andre L. Samson, Stephane Chappaz, Seong L. Khaw, Catherine Chang, Andrew Morokoff, Kerstin Brinkmann, Andrew Webb, Colin Hockings, Cathrine M. Hall, Andrew J. Kueh, Michael T. Ryan, Ruth M. Kluck, Philippe Bouillet, Marco J. Herold, Daniel H. D. Gray, David C. S. Huang, Mark F. van Delft and Grant Dewson. https://www.nature.com/articles/s41467-018-07309-4

Mannose impairs tumour growth and enhances chemotherapy – Pablo Sierra Gonzalez, James O’Prey, Simone Cardaci, Valentin J. A. Barthet, Jun-ichi Sakamaki, Florian Beaumatin, Antonia Roseweir, David M. Gay, Gillian Mackay, Gaurav Malviya, Elżbieta Kania, Shona Ritchie, Alice D. Baudot, Barbara Zunino, Agata Mrowinska, Colin Nixon, Darren Ennis, Aoisha Hoyle, David Millan, Iain A. McNeish, Owen J. Sansom, Joanne Edwards and Kevin M. Ryan. https://www.nature.com/articles/s41586-018-0729-3

Venetoclax with azacitidine disrupts energy metabolism and targets leukemia stem cells in patients with acute myeloid leukemia – Daniel A. Pollyea, Brett M. Stevens[…], Craig T. Jordan. https://www.nature.com/articles/s41591-018-0233-1

And the companion paper:
Inhibition of Amino Acid Metabolism Selectively Targets Human Leukemia Stem Cells – Courtney L. Jones, Brett M. Stevens, Angelo D’Alessandro, Julie A. Reisz, Rachel Culp-Hill, Travis Nemkov, Shanshan Pei, Nabilah Khan, Biniam Adane, Haobin Ye, Anna Krug, Dominik Reinhold, Clayton Smith, James DeGregori, Daniel A. Pollyea, Craig T. Jordan. https://www.cell.com/cancer-cell/fulltext/S1535-6108(18)30471-9

Tamoxifen overrides autophagy inhibition in Beclin-1-deficient glioma cells and their resistance to adenovirus-mediated oncolysis via upregulation of PUMA and BAX – Natalya V. Kaverina, Zaira G. Kadagidze, Anton V. Borovjagin, Apollon I. Karseladze, Chung Kwon Kim, Maciej S. Lesniak, Jason Miska, Peng Zhang, Maria A. Baryshnikova, Ting Xiao, David Ornelles, Charles Cobbs, Andrey Khramtsov and Ilya V. Ulasov. https://www.nature.com/articles/s41388-018-0395-9

NOXA genetic amplification or pharmacologic induction primes lymphoma cells to BCL2 inhibitor-induced cell death – Yuxuan Liu, Patrizia Mondello, Tatiana Erazo, Neeta Bala Tannan, Zahra Asgari, Elisa de Stanchina, Gouri Nanjangud, Venkatraman E. Seshan, Shenqiu Wang, Hans-Guido Wendel and Anas Younes. http://www.pnas.org/content/115/47/12034?etoc=

Cytoplasmic pro-apoptotic function of the tumor suppressor p73 is mediated through a modified mode of recognition of the anti-apoptotic regulator Bcl-XL – Mi-Kyung Yoon, Bu-Yeon Kim, Ji-Young Lee, Ji-Hyang Ha, Sung Ah Kim, Dong-Hwa Lee, Min-Sung Lee, Mi-Kyung Lee, Jin Sun Choi, Jin Hwa Cho, Jeong-Hoon Kim, Sunhong Kim, Jaewhan Song, Sung Goo Park, Byoung Chul Park, Kwang-Hee Bae, Sang Un Choi and Seung-Wook Chi. http://www.jbc.org/content/early/2018/11/14/jbc.RA118.003061.abstract


Caspases


Caspases maintain tissue integrity by an apoptosis-independent inhibition of cell migration and invasion – Anna Gorelick-Ashkenazi, Ron Weiss, Lena Sapozhnikov, Anat Florentin, Lama Tarayrah-Ibraheim, Dima Dweik, Keren Yacobi-Sharon and Eli Arama. https://www.nature.com/articles/s41467-018-05204-6

Identification of a novel caspase cleavage site in huntingtin that regulates mutant huntingtin clearance – Dale D. O. Martin, Mandi E. Schmidt, Yen T. Nguyen, Nikola Lazic and Michael R. Hayden. https://www.fasebj.org/doi/abs/10.1096/fj.201701510RRR?ai=ts&ui=ly8&af=T

14‐3‐3 protein masks the nuclear localization sequence of caspase‐2 – Aneta Smidova, Miroslava Alblova, Dana Kalabova, Katarina Psenakova, Michal Rosulek, Petr Herman, Tomas Obsil, Veronika Obsilova. https://febs.onlinelibrary.wiley.com/doi/10.1111/febs.14670

Tri-arginine exosite patch of caspase-6 recruits substrates for hydrolysis – Derek J MacPherson, Caityln L Mills, Mary Jo Ondrechen and Jeanne A. Hardy. http://www.jbc.org/content/early/2018/11/12/jbc.RA118.005914.abstract

p53 accumulation following cytokinesis failure in the absence of caspase-2 (letter) – Yoon Lim, Dylan De Bellis, Loretta Dorstyn and Sharad Kumar. https://www.nature.com/articles/s41418-018-0161-0

microRNA-378 promotes autophagy and inhibits apoptosis in skeletal muscle – Yan Li, Jingjing Jiang, Wei Liu, Hui Wang, Lei Zhao, Shengnan Liu, Peng Li, Shengjie Zhang, Chao Sun, Yuting Wu, Shuxian Yu, Xihua Li, Hui Zhang, Haifeng Qian, Duo Zhang, Feifan Guo, Qiwei Zhai, Qiurong Ding, Li Wang and Hao Ying. http://www.pnas.org/content/115/46/E10849?etoc=

Platelet CD36 signaling through ERK5 promotes caspase-dependent procoagulant activity and fibrin deposition in vivo – Moua Yang, Andaleb Kholmukhamedov, Marie L. Schulte, Brian C. Cooley, Na’il O. Scoggins, Jeremy P. Wood, Scott J. Cameron, Craig N. Morrell, Shawn M. Jobeand Roy L. Silverstein. http://www.bloodadvances.org/content/2/21/2848.abstract?etoc


Necroptosis


Axonal degeneration induced by glutamate excitotoxicity is mediated by necroptosis – Diego E. Hernández, Natalia A. Salvadores, Guillermo Moya-Alvarado, Romina J. Catalán, Francisca C. Bronfman and Felipe A. Court. http://jcs.biologists.org/content/131/22/jcs214684?etoc

Soluble TNF-like weak inducer of apoptosis (TWEAK) enhances poly(I:C)-induced RIPK1-mediated necroptosis – Mohamed A. Anany, Jennifer Kreckel, Simone Füllsack, Alevtina Rosenthal, Christoph Otto, Daniela Siegmund and Harald Wajant. https://www.nature.com/articles/s41419-018-1137-1

hsa-miR-500a-3P alleviates kidney injury by targeting MLKL-mediated necroptosis in renal epithelial cells – Ling Jiang, Xue-Qi Liu, Qiuying Ma, Qin Yang, Li Gao, Hai-Di Li, Jia-Nan Wang, Biao Wei, Jiagen Wen, Jun Li, Yong-Gui Wu and Xiao-Ming Meng. https://www.fasebj.org/doi/abs/10.1096/fj.201801711R?ai=ts&ui=ly8&af=T


Miscellanous


The Proton-Coupled Monocarboxylate Transporter Hermes Is Necessary for Autophagy during Cell Death – Panagiotis D. Velentzas, Lejie Zhang, Gautam Das, Tsun-Kai Chang, Charles Nelson, William R. Kobertz, Eric H. Baehrecke. https://www.cell.com/developmental-cell/fulltext/S1534-5807(18)30744-5

Intracellular transport is accelerated in early apoptotic cells – Bo Li, Shuo-Xing Dou, Jing-Wen Yuan, Yu-Ru Liu, Wei Li, Fangfu Ye, Peng-Ye Wang and Hui Li. http://www.pnas.org.sire.ub.edu/content/115/48/12118?etoc=

The yeast mitochondrial permeability transition is regulated by reactive oxygen species, endogenous Ca2+ and Cpr3, mediating cell death – Yoshiko Kamei, Masami Koushi, Yasunori Aoyama, Rei Asakai. https://www.sciencedirect.com/science/article/pii/S000527281830197X

microRNAs selectively protect hub cells of the germline stem cell niche from apoptosis – Marina Volin, Maayan Zohar-Fux, Oren Gonen, Lilach Porat-Kuperstein and Hila Toledano. http://jcb.rupress.org/content/217/11/3829?etoc


Reviews


FLIP as a therapeutic target in cancer – Luke Humphreys, Margarita Espona‐Fiedler, Daniel B. Longley. https://febs.onlinelibrary.wiley.com/doi/10.1111/febs.14523

Counting on Death – Quantitative aspects of Bcl‐2 family regulation – Annika Hantusch, Markus Rehm, Thomas Brunner. https://febs.onlinelibrary.wiley.com/doi/10.1111/febs.14516

Cell-in-cell phenomena in cancer – Stefano Fais and Michael Overholtzer. https://www.nature.com/articles/s41568-018-0073-9

FADD at the Crossroads between Cancer and Inflammation – Sara Mouasni, Léa Tourneur. https://www.cell.com/trends/immunology/fulltext/S1471-4906(18)30189-3

Hematologic Tumor Cell Resistance to the BCL-2 Inhibitor Venetoclax: A Product of Its Microenvironment? – Joel D. Leverson and Dan Cojocari. https://www.frontiersin.org/articles/10.3389/fonc.2018.00458/full

Dependence receptors – the dark side awakens – Ana‐Maria Negulescu, Patrick Mehlen. https://febs.onlinelibrary.wiley.com/doi/10.1111/febs.14507


Comments


Unleashing Blocked Apoptosis in Cancer Cells: New MCL1 Inhibitors Find Their Groove – Brian Leber, Justin Kale and David W. Andrews. http://cancerdiscovery.aacrjournals.org/content/8/12/1511?

TBK1 and IKKε restrain cell death – Klaus Heger and Vishva M. Dixit. https://www.nature.com/articles/s41556-018-0239-4

Timed degradation of Mcl-1 controls mitotic cell death – Paul R. Clarke, Lindsey A. Allan and Agnieszka Skowyra. https://www.tandfonline.com/doi/full/10.1080/23723556.2018.1516450

Necroptosis is key to axonal degeneration after excitotoxicity. http://jcs.biologists.org/content/131/22/e2202?etoc

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ApoList – November 2013

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Non apoptotic cell death
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Widespread Mitochondrial Depletion via Mitophagy Does Not Compromise Necroptosis
Stephen W.G. Tait, Andrew Oberst, Giovanni Quarato, Sandra Milasta, Martina Haller, Ruoning Wang, Maria Karvela, Gabriel Ichim, Nader Yatim, Matthew L. Albert, Grahame Kidd, Randall Wakefield, Sharon Frase, Stefan Krautwald, Andreas Linkermann, Douglas R. Green
http://www.cell.com/cell-reports/fulltext/S2211-1247(13)00618-9

mTOR regulates phagosome and entotic vacuole fission
Matej Krajcovic, Shefali Krishna, Leila Akkari, Johanna A. Joyce, and Michael Overholtzer
http://www.molbiolcell.org/content/24/23/3736.abstract.html?etoc

Intracellular pH reduction prevents excitotoxic and ischemic neuronal death by inhibiting NADPH oxidase
Tina I. Lam, Angela M. Brennan-Minnella, Seok Joon Won, Yiguo Shen, Colleen Hefner, Yejie Shi, Dandan Sun, and Raymond A. Swanson
http://www.pnas.org/content/110/46/E4362.abstract.html?etoc

Clostridium difficile toxin B-induced necrosis is mediated by the host epithelial cell NADPH oxidase complex
Melissa A. Farrow, Nicole M. Chumbler, Lynne A. Lapierre, Jeffrey L. Franklin, Stacey A. Rutherford, James R. Goldenring, and D. Borden Lacy
http://www.pnas.org/content/110/46/18674.abstract.html?etoc

Endonuclease G mediates α-synuclein cytotoxicity during Parkinson’s disease
Sabrina Büttner, Lukas Habernig, Filomena Broeskamp, Doris Ruli, F Nora Vögtle, Manolis Vlachos, Francesca Macchi, Victoria Küttner, Didac Carmona-Gutierrez, Tobias Eisenberg, Julia Ring, Maria Markaki, Asli Aras Taskin, Stefan Benke, Christoph Ruckenstuhl, Ralf Braun, Chris Van den Haute, Tine Bammens, Anke van der Perren, Kai-Uwe Fröhlich, Joris Winderickx, Guido Kroemer, Veerle Baekelandt, Nektarios Tavernarakis, Gabor G Kovacs, Jörn Dengjel, Chris Meisinger, Stephan J Sigrist and Frank Madeo
http://www.nature.com/emboj/journal/v32/n23/abs/emboj2013228a.html

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Bcl-2 family proteins
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BIM-Mediated Membrane Insertion of the BAK Pore Domain Is an Essential Requirement for Apoptosis
Kathrin Weber, Nicholas Harper, John Schwabe, Gerald M. Cohen
http://www.cell.com/cell-reports/abstract/S2211-1247(13)00518-4

Combined Targeting of JAK2 and Bcl-2/Bcl-xL to Cure Mutant JAK2-Driven Malignancies and Overcome Acquired Resistance to JAK2 Inhibitors
Michaela Waibel, Vanessa S. Solomon, Deborah A. Knight, Rachael A. Ralli, Sang-Kyu Kim, Kellie-Marie Banks, Eva Vidacs, Clemence Virely, Keith C.S. Sia, Lauryn S. Bracken, Racquel Collins-Underwood, Christina Drenberg, Laura B. Ramsey, Sara C. Meyer, Megumi Takiguchi, Ross A. Dickins, Ross Levine, Jacques Ghysdael, Mark A. Dawson, Richard B. Lock, Charles G. Mullighan, Ricky W. Johnstone
http://www.cell.com/cell-reports/abstract/S2211-1247(13)00637-2

Polyubiquitination and proteasomal turnover controls the anti-apoptotic activity of Bcl-B
B van de Kooij, R W Rooswinkel, F Kok, M Herrebout, E de Vries, M Paauwe, G M C Janssen, P A van Veelen and J Borst
http://www.nature.com/onc/journal/v32/n48/abs/onc201399a.html

Critical role of anti-apoptotic Bcl-2 protein phosphorylation in mitotic death
J M Eichhorn, N Sakurikar, S E Alford, R Chu and T C Chambers
http://www.nature.com/cddis/journal/v4/n10/abs/cddis2013360a.html

Purported Mcl-1 inhibitor marinopyrrole A fails to show selective cytotoxicity for Mcl-1-dependent cell lines
J M Eichhorn, S E Alford, C C Hughes, W Fenical and T C Chambers
http://www.nature.com/cddis/journal/v4/n10/full/cddis2013411a.html

Bortezomib antagonizes microtubule-interfering drug-induced apoptosis by inhibiting G2/M transition and MCL-1 degradation
F Rapino, I Naumann and S Fulda
http://www.nature.com/cddis/journal/v4/n11/abs/cddis2013440a.html

BCL-XL Mediates the Strong Selective Advantage of a 20q11.21 Amplification Commonly Found in Human Embryonic Stem Cell Cultures
S. Avery, A.J. Hirst, D. Baker, C.Y. Lim, S. Alagaratnam, R.I. Skotheim, R.A. Lothe, M.F. Pera, A. Colman, P. Robson, P.W. Andrews, and B.B. Knowles
http://www.cell.com/stem-cell-reports/fulltext/S2213-6711(13)00099-4

MCL-1ES Induces MCL-1L-Dependent BAX- and BAK-Independent Mitochondrial Apoptosis
Jae-Hong Kim, Jeehyeon Bae
http://www.plosone.org/article/info:doi/10.1371/journal.pone.0079626

HER2 Phosphorylates and Destabilizes Pro-Apoptotic PUMA, Leading to Antagonized Apoptosis in Cancer Cells
Richard L. Carpenter, Woody Han, Ivy Paw, Hui-Wen Lo
http://www.plosone.org/article/info:doi/10.1371/journal.pone.0078836

Evaluation of the BH3-Only Protein Puma as a Direct Bak Activator
Haiming Dai, Yuan-Ping Pang, Marina Ramirez-Alvarado, and Scott H. Kaufmann
http://www.jbc.org/content/early/2013/11/21/jbc.M113.505701.abstract

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Death receptor pathway
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CD95L Cell Surface Cleavage Triggers a Prometastatic Signaling Pathway inTriple-Negative Breast Cancer
Marine Malleter, Sébastien Tauzin, Alban Bessede, Rémy Castellano, Armelle Goubard, Florence Godey, Jean Levêque, Pascal Jézéquel, Loic Campion, Mario Campone, Thomas Ducret, Gaëtan MacGrogan, Laure Debure, Yves Collette, Pierre Vacher, and Patrick Legembre
http://cancerres.aacrjournals.org/content/73/22/6711.abstract.html?etoc

Autocrine TNF-α production supports CML stem and progenitor cell survival and enhances their proliferation
Paolo Gallipoli, Francesca Pellicano, Heather Morrison, Kamilla Laidlaw, Elaine K. Allan, Ravi Bhatia, Mhairi Copland, Heather G. Jørgensen, and Tessa L. Holyoake
http://bloodjournal.hematologylibrary.org/content/122/19/3335.abstract.html?etoc

Ubiquitination-Deubiquitination by the TRIM27-USP7 Complex Regulates Tumor Necrosis Factor Alpha-Induced Apoptosis
Mohammad Mahabub-Uz Zaman, Teruaki Nomura, Tsuyoshi Takagi, Tomoo Okamura, Wanzhu Jin, Toshie Shinagawa, Yasunori Tanaka, and Shunsuke Ishii
http://mcb.asm.org/content/33/24/4971.abstract?etoc

Reduction of Decoy Receptor 3 Enhances TRAIL-Mediated Apoptosis in Pancreatic Cancer
Wei Wang, Mei Zhang, Weimin Sun, Shanmin Yang, Ying Su, Hengshan Zhang, Chaomei Liu, Xinfeng Li, Ling Lin, Sunghee Kim, Paul Okunieff, Zhenhuan Zhang, Lurong Zhang
http://www.plosone.org/article/info:doi/10.1371/journal.pone.0074272

Decreased affinity of rhTRAIL-D269H/E195R to OPG overcomes TRAIL-resistance mediated by the bone microenvironment
Matthieu C.J. Bosman, Carlos R. Reis, Jan J. Schuringa, Edo Vellenga, and Wim J. Quax
http://www.jbc.org/content/early/2013/11/26/jbc.M113.491589.abstract

The c-FLIPL cleavage product p43FLIP promotes activation of ERK, NF-κB, caspase-8 and T cell survival
Andreas Koenig, Iwona A. Buskiewicz, Karen A. Fortner, Jennifer Q. Russell, Tomoko Asaoka, You-Wen He, Razqallah Hakem, John E. Eriksson, and Ralph C. Budd
http://www.jbc.org/content/early/2013/11/25/jbc.M113.506428.abstract

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Caspases and downstream / IAPs
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Caspase-mediated activation of Caenorhabditis elegans CED-8 promotes apoptosis and phosphatidylserine externalization
Yu-Zen Chen, James Mapes, Eui-Seung Lee, Riley Robert Skeen-Gaar and Ding Xue
http://www.nature.com/ncomms/2013/131114/ncomms3726/full/ncomms3726.html

TRIM13 regulates caspase-8 ubiquitination, translocation to autophagosomes and activation during ER stress induced cell death
Dhanendra Tomar, Paresh Prajapati, Lakshmi Sripada, Kritarth Singh, Rochika Singh, Arun Kumar Singh, Rajesh Singh
http://www.sciencedirect.com/science/article/pii/S0167488913003200

The HECTD3 E3 ubiquitin ligase facilitates cancer cell survival by promoting K63-linked polyubiquitination of caspase-8
Y Li, Y Kong, Z Zhou, H Chen, Z Wang, Y-C Hsieh, D Zhao, X Zhi, J Huang, J Zhang, H Li and C Chen
http://www.nature.com/cddis/journal/v4/n11/abs/cddis2013464a.html

Expression and Activation of Caspase-6 in Human Fetal and Adult Tissues
Nelly Godefroy, Bénédicte Foveau, Steffen Albrecht, Cynthia G. Goodyer, Andréa C. LeBlanc
http://www.plosone.org/article/info:doi/10.1371/journal.pone.0079313

A novel mechanism of XIAP degradation induced by timosaponin AIII in hepatocellular carcinoma
Ning Wang, Yibin Feng, Meifen Zhu, Fung-Ming Siu, Kwan-Ming Ng, Chi-Ming Che
http://www.sciencedirect.com/science/article/pii/S0167488913002930

Identification of DR5 as a critical, NF-κB-regulated mediator of Smac-induced apoptosis
I Eckhardt, S Roesler and S Fulda
http://www.nature.com/cddis/journal/v4/n11/abs/cddis2013457a.html

Smac mimetics induce inflammation and necrotic tumour cell death by modulating macrophage activity
D Lecis, M De Cesare, P Perego, A Conti, E Corna, C Drago, P Seneci, H Walczak, M P Colombo, D Delia and S Sangaletti
http://www.nature.com/cddis/journal/v4/n11/abs/cddis2013449a.html

———————–
Miscellaneous
———————–

Metabolic Activation of CaMKII by Coenzyme A
Francis McCoy, Rashid Darbandi, Hoi Chang Lee, Kavitha Bharatham, Tudor Moldoveanu, Christy R. Grace, Keela Dodd, Wenwei Lin, Si-Ing Chen, Rajendra P. Tangallapally, Manabu Kurokawa, Richard E. Lee, Anang A. Shelat, Taosheng Chen, Douglas R. Green, Robert A. Harris, Sue-Hwa Lin, Rafael A. Fissore, Roger J. Colbran, Leta K. Nutt
http://www.cell.com/molecular-cell/abstract/S1097-2765(13)00643-6

Macromitophagy, neutral lipids synthesis, and peroxisomal fatty acid oxidation protect yeast from “liponecrosis”, a previously unknown form of programmed cell death
Sara Sheibani, Vincent R Richard, Adam Beach, Anna Leonov, Rachel Feldman, Leila Khelghatybana, Amanda Piano, Michael Greenwood, Hojatollah Vali and Vladimir I Titorenko
https://www.landesbioscience.com/journals/cc/article/26696/

Programmed Cell Senescence during Mammalian Embryonic Development
Daniel Muñoz-Espín, Marta Cañamero, Antonio Maraver, Gonzalo Gómez-López, Julio Contreras, Silvia Murillo-Cuesta, Alfonso Rodríguez-Baeza, Isabel Varela-Nieto, Jesús Ruberte, Manuel Collado, Manuel Serrano
http://www.cell.com/abstract/S0092-8674(13)01295-6

Senescence Is a Developmental Mechanism that Contributes to Embryonic Growth and Patterning
Mekayla Storer, Alba Mas, Alexandre Robert-Moreno, Matteo Pecoraro, M. Carmen Ortells, Valeria Di Giacomo, Reut Yosef, Noam Pilpel, Valery Krizhanovsky, James Sharpe, William M. Keyes
http://www.cell.com/abstract/S0092-8674(13)01359-7

Granulysin induces apoptotic cell death and cleavage of the autophagy regulator Atg5 in human hematological tumors.
Adriana Aporta, Elena Catalán, Patricia Galán-Malo, Ariel Ramírez-Labrada, Marta Pérez, Gemma Azaceta, Luis Palomera, Javier Naval, Isabel Marzo, Julián Pardo, Alberto Anel
http://www.sciencedirect.com/science/article/pii/S0006295213007351

—————
Reviews
—————

Mitochondria: gatekeepers of response to chemotherapy
Kristopher A. Sarosiek, Triona Ni Chonghaile, Anthony Letai
http://www.cell.com/trends/cell-biology/abstract/S0962-8924(13)00136-0

On the TRAIL of obesity and diabetes
Hanis H. Harith, Margaret J. Morris, Mary M. Kavurma
http://www.cell.com/trends/endocrinology-metabolism/abstract/S1043-2760(13)00120-3

Structural biology of the Bcl-2 family and its mimicry by viral proteins
M Kvansakul and M G Hinds
http://www.nature.com/cddis/journal/v4/n11/abs/cddis2013436a.html

Evading apoptosis in cancer
Kaleigh Fernald, Manabu Kurokawa
http://www.cell.com/trends/cell-biology/abstract/S0962-8924(13)00117-7

Developmentally programmed cell death in Drosophila
Donna Denton, May T. Aung-Htut, Sharad Kumar
http://www.sciencedirect.com/science/article/pii/S0167488913002371

When ER stress reaches a dead end
Hery Urra, Estefanie Dufey, Fernanda Lisbona, Diego Rojas-Rivera, Claudio Hetz
http://www.sciencedirect.com/science/article/pii/S016748891300311X

Crosstalk between apoptosis, necrosis and autophagy
Vassiliki Nikoletopoulou, Maria Markaki, Konstantinos Palikaras, Nektarios Tavernarakis
http://www.sciencedirect.com/science/article/pii/S0167488913002243

ER stress-induced cell death mechanisms
Renata Sano, John C. Reed
http://www.sciencedirect.com/science/article/pii/S0167488913002516

Cell death by cornification
Leopold Eckhart, Saskia Lippens, Erwin Tschachler, Wim Declercq
http://www.sciencedirect.com/science/article/pii/S0167488913002334

Anoikis molecular pathways and its role in cancer progression
Paolo Paoli, Elisa Giannoni, Paola Chiarugi
http://www.sciencedirect.com/science/article/pii/S0167488913002498

Mitosis and apoptosis: how is the balance set?
Caroline H Topham, Stephen S Taylor
http://www.sciencedirect.com/science/article/pii/S0955067413001178

—————–
Comments
—————–

Endonuclease-G and the pathways to dopaminergic neurodegeneration: a question of location?
Marion C Hogg and Jochen H M Prehn
http://www.nature.com/emboj/journal/v32/n23/full/emboj2013238a.html

BH3-only proteins, Bmf and Bim, in autophagy
Monica Delgado and Yohannes Tesfaigzi
https://www.landesbioscience.com/journals/cc/article/26696/

MCL1 is critical for mitochondrial function and autophagy in the heart
Robert L Thomas and Åsa B Gustafsson
https://www.landesbioscience.com/journals/autophagy/article/26168/

Proapoptotic BH3-Only Proteins Have Different Activation Preferences
http://cancerdiscovery.aacrjournals.org/content/3/11/1219.2.abstract.html?etoc

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Apolist – january 10

BCL-2 FAMILY PROTEINS

Deubiquitinase USP9X stabilizes MCL1 and promotes tumour cell survival
Martin Schwickart et al.
http://www.nature.com/nature/journal/v463/n7277/full/nature08646.html

Regulation of stress-induced nuclear protein redistribution: a new function of Bax and Bak uncoupled from Bcl-xL
L Lindenboim, E Blacher, C Borner and R Stein
http://www.nature.com/cdd/journal/v17/n2/abs/cdd2009145a.html

The Antiapoptotic Protein BCL2L1/BCL-XL is Neutralized by Proapoptotic PMAIP1/Noxa in Neuroblastoma Thereby Determining Bortezomib-Sensitivity Independent of Prosurvival MCL1 Expression
Judith Hagenbuchner, Michael J. Ausserlechner, Verena Porto, Reinhard David, Bernhard Meister, Martin Bodner, Andreas Villunger, Kathrin Geiger, and Petra Obexer
J. Biol. Chem. published 5 January 2010, 10.1074/jbc.M109.038331
http://www.jbc.org/cgi/content/abstract/M109.038331v1

Rheb GTPase controls apoptosis by regulating the interaction of FKBP38 with Bcl-2 and Bcl-XL
Dongzhu Ma, Xiaochun Bai, Huafei Zou, Yumei Lai, and Yu Jiang
J. Biol. Chem. published 4 January 2010, 10.1074/jbc.M109.092353
http://www.jbc.org/cgi/content/abstract/M109.092353v1

The Bax carboxy-terminal hydrophobic helix does not determine organelle-specific targeting but is essential for maintaining Bax in an inactive state and for stable mitochondrial membrane insertion
Stephanie E. Brock, Chi Li & Binks W. Wattenberg
http://www.springerlink.com/content/bkmqg7w044600051/

Mcl-1128–350 fragment induces apoptosis through direct interaction with Bax
Emmanuelle Ménoret, Patricia Gomez-Bougie, Sylvanie Surget, Valérie Trichet, Lisa Oliver, Catherine Pellat-Deceunynck, Martine Amiot
http://dx.doi.org/10.1016/j.febslet.2009.11.094

Myeloid progenitor cells lacking p53 exhibit delayed up-regulation of Puma and prolonged survival after cytokine deprivation
Anissa M. Jabbour, Carmel P. Daunt, Benjamin D. Green, Sandra Vogel, Lavinia Gordon, Rachel S. Lee, Natasha Silke, Richard B. Pearson, Cassandra J. Vandenberg, Priscilla N. Kelly, Stephen L. Nutt, Andreas Strasser, Christoph Borner, and Paul G. Ekert
Blood 2010;115 344-352
http://bloodjournal.hematologylibrary.org/cgi/content/abstract/115/2/344

Interleukin-7 Regulates Bim Proapoptotic Activity in Peripheral T-Cell Survival
Wen Qing Li, Tad Guszczynski, Julie A. Hixon, and Scott K. Durum
Mol. Cell. Biol. 2010;30 590-600
http://mcb.asm.org/cgi/content/abstract/30/3/590

Cyclin-Dependent Kinase 1-Mediated Bcl-xL/Bcl-2 Phosphorylation Acts as a Functional Link Coupling Mitotic Arrest and Apoptosis
David T. Terrano, Meenakshi Upreti, and Timothy C. Chambers
Mol. Cell. Biol. 2010;30 640-656
http://mcb.asm.org/cgi/content/abstract/30/3/640

Differential Dependence on Beclin 1 for the Regulation of Pro-Survival Autophagy by Bcl-2 and Bcl-xL in HCT116 Colorectal Cancer Cells
Muriel Priault, Erika Hue, Fanny Marhuenda, Paul Pilet, Lisa Oliver, François M. Vallette
http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0008755

Prevention of premature senescence requires JNK regulation of Bcl-2 and reactive oxygen species
J -J Lee, J -H Lee, Y -G Ko, S I Hong and J -S Lee
http://www.nature.com/onc/journal/v29/n4/abs/onc2009355a.html

.

Death receptors and IAPs

Caspase-Mediated Cleavage, IAP Binding, and Ubiquitination: Linking Three Mechanisms Crucial for Drosophila NF-κB Signaling
N. Paquette, M. Broemer, K. Aggarwal, L. Chen, M. Husson, D. Ertürk-Hasdemir, J.-M. Reichhart, P. Meier, and N. Silverman
http://www.cell.com/molecular-cell/abstract/S1097-2765(10)00039-0

TAK1 Is Required for Survival of Mouse Fibroblasts Treated with TRAIL, and Does So by NF-κB Dependent Induction of cFLIPL
Josep Maria Lluis, Ulrich Nachbur, Wendy Diane Cook, Ian Edward Gentle, Donia Moujalled, Maryline Moulin, Wendy Wei-Lynn Wong, Nufail Khan, Diep Chau, Bernard Andrew Callus, James Edward Vince, John Silke, David Lawrence Vaux
http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0008620

Akt promotes chemoresistance in human ovarian cancer cells by modulating cisplatin-induced, p53-dependent ubiquitination of FLICE-like inhibitory protein
M R Abedini, E J Muller, R Bergeron, D A Gray and B K Tsang
http://www.nature.com/onc/journal/v29/n1/abs/onc2009300a.html

Histone deacetylase inhibitors induce thyroid cancer-specific apoptosis through proteasome-dependent inhibition of TRAIL degradation
E Borbone, M T Berlingieri, F De Bellis, A Nebbioso, G Chiappetta, A Mai, L Altucci and A Fusco
http://www.nature.com/onc/journal/v29/n1/abs/onc2009306a.html

Avicin D, a Plant Triterpenoid, Induces Cell Apoptosis by Recruitment of Fas and Downstream Signaling Molecules into Lipid Rafts
Zhi-Xiang Xu, Tian Ding, Valsala Haridas, Fiona Connolly, Jordan U. Gutterman
http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0008532

IAP Regulation of Metastasis
S. Mehrotra, L.R. Languino, C.M. Raskett, A.M. Mercurio, T. Dohi, and D.C. Altieri
http://www.cell.com/cancer-cell/abstract/S1535-6108%2809%2900422-X

Targeting a novel N-terminal epitope of death receptor 5 triggers tumor cell death
Peng Zhang, Yong Zheng, Juan Shi, Yaxi Zhang, Shilian Liu, Yanxin Liu, and Dexian Zheng
J. Biol. Chem. published 27 January 2010, 10.1074/jbc.M109.070680
http://www.jbc.org/cgi/content/abstract/M109.070680v1

Multivalent DR5 Peptides Activate the TRAIL Death Pathway and Exert Tumoricidal Activity
Valeria Pavet, Julien Beyrath, Christophe Pardin, Alexandre Morizot, Marie-Charlotte Lechner, Jean-Paul Briand, Miriam Wendland, Wolfgang Maison, Sylvie Fournel, Olivier Micheau, Gilles Guichard, and Hinrich Gronemeyer
Cancer Res 2010;70 1101-1110
http://cancerres.aacrjournals.org/cgi/content/abstract/70/3/1101

Tumor necrosis factor–related apoptosis-inducing ligand 1 (TRAIL1) enhances the transition of red blood cells from the larval to adult type during metamorphosis in Xenopus
Kei Tamura, Shuuji Mawaribuchi, Shin Yoshimoto, Tadayoshi Shiba, Nobuhiko Takamatsu, and Michihiko Ito
Blood 2010;115 850-859
http://bloodjournal.hematologylibrary.org/cgi/content/abstract/115/4/850

.

Apoptotic process

Inhibition of a protein kinase Akt1 by apoptosis signal-regulating kinase-1 (ASK1) is involved in apoptotic inhibition of regulatory volume increase
Muthangi Subramanyam, Nobuyuki Takahashi, Yuichi Hasegawa, Tatsuma Mohri, and Yasunobu Okada
J. Biol. Chem. published 4 January 2010, 10.1074/jbc.M109.072785
http://www.jbc.org/cgi/content/abstract/M109.072785v1

Apoptosis blocks Beclin 1-dependent autophagosome synthesis: an effect rescued by Bcl-xL
S Luo and D C Rubinsztein
http://www.nature.com/cdd/journal/v17/n2/abs/cdd2009121a.html

Engineering a polarity-sensitive biosensor for time-lapse imaging of apoptotic processes and degeneration pp67 – 73
Yujin E Kim, Jeannie Chen, Jonah R Chan and Ralf Langen
http://www.nature.com/nmeth/journal/v7/n1/abs/nmeth.1405.html?lang=en

.

OTHER

Dynein light chain 1 is required for autophagy, protein clearance, and cell death in Drosophila
Yakup Batlevi, Damali N. Martin, Udai Bhan Pandey, Claudio R. Simon, Christine M. Powers, J. Paul Taylor, and Eric H. Baehrecke
http://www.pnas.org/cgi/content/abstract/107/2/742?etoc

Rab5 Mediates Caspase-8–promoted Cell Motility and Metastasis
Vicente A. Torres, Ainhoa Mielgo, Simone Barbero, Ruth Hsiao, John A. Wilkins, and Dwayne G. Stupack
http://www.molbiolcell.org/cgi/content/abstract/21/2/369?etoc

The apoptotic machinery as a biological complex system: analysis of its omics and evolution, identification of candidate genes for fourteen major types of cancer, and experimental validation in CML and neuroblastoma
Di Pietro, C; Ragusa, M; Barbagallo, D; Duro, LR; Guglielmino, MR; Majorana, A; Angelica, R; Scalia, M; Statello, L; Salito, L; Tomasello, L; Pernagallo, S; Valenti, S; D’Agostino, V; Triberio, P; Tandurella, I; Palumbo, GA; La Cava, P; Cafiso, V; Bertuccio, T; Santagati, M; Destri, GL; Lanzafame, S; Di Raimondo, F; Stefani, S; Mishra, B; Purrello, M
http://www.biomedcentral.com/1755-8794/2/20

Positive selection on apoptosis related genes
Rute R. da Fonseca, Carolin Kosiol, Tomáš Vinař, Adam Siepel, Rasmus Nielsen
http://dx.doi.org/10.1016/j.febslet.2009.12.022

Coupling of the cell cycle and apoptotic machineries in developing T cells
Ling Xue, Yuefang Sun, Leslie Chiang, Bo He, Chulho Kang, Hector Nolla, and Astar Winoto
J. Biol. Chem. published 12 January 2010, 10.1074/jbc.M109.035535
http://www.jbc.org/cgi/content/abstract/M109.035535v1

p53 Controls Radiation-Induced Gastrointestinal Syndrome in Mice Independent of Apoptosis
D. G. Kirsch et al.
http://www.sciencemag.org/cgi/content/abstract/327/5965/593

.
Reviews

Several reviews on microRNAs and cell death/cancer in CDD:
MicroRNAs meet cell death
G Melino and R A Knight
http://www.nature.com/cdd/journal/v17/n2/full/cdd2009122a.html

Cellular and nuclear degradation during apoptosis
Pages 900-912
Bin He, Nan Lu, Zheng Zhou
http://dx.doi.org/10.1016/j.ceb.2009.08.008

Modulation of apoptosis by early human papillomavirus proteins in cervical cancer
A. Lagunas-Martínez, V. Madrid-Marina, P. Gariglio
http://dx.doi.org/10.1016/j.bbcan.2009.03.005

Transcription-independent p53 apoptosis: an alternative route to death
Daniel Speidel
http://www.cell.com/trends/cell-biology/abstract/S0962-8924(09)00240-2

Apolist – december 09

BH3

Glycolysis inhibition sensitizes tumor cells to death receptors-induced apoptosis by AMP kinase activation leading to Mcl-1 block in translation.
Pradelli LA, Bénéteau M, Chauvin C, Jacquin MA, Marchetti S, Muñoz-Pinedo C, Auberger P, Pende M, Ricci JE.
http://www.nature.com/onc/journal/vaop/ncurrent/full/onc2009448a.html

Caspase-independent Mitochondrial Cell Death Results from Loss of Respiration, Not Cytotoxic Protein Release
Lydia Lartigue, Yulia Kushnareva, Youngmo Seong, Helen Lin, Benjamin Faustin, and Donald D. Newmeyer
http://www.molbiolcell.org/cgi/content/abstract/20/23/4871?etoc

Single-cell quantification of Bax activation and mathematical modelling suggest pore formation on minimal mitochondrial Bax accumulation
HDüssmann, M Rehm, C G Concannon, S Anguissola, M Würstle, S Kacmar, P Völler, H J Huber and J H M Prehn
http://www.nature.com/cdd/journal/vaop/ncurrent/full/cdd2009123a.html

Functional Cooperation of the Proapoptotic Bcl2 Family Proteins Bmf and Bim In Vivo
Anette Hübner, Julie Cavanagh-Kyros, Mercedes Rincon, Richard A. Flavell, and Roger J. Davis
Mol. Cell. Biol. 2010;30 98-105
http://mcb.asm.org/cgi/content/abstract/30/1/98

Identification of proapoptotic Bim as a tumor suppressor in neoplastic mast cells: role of KIT D816V and effects of various targeted drugs
Karl J. Aichberger, Karoline V. Gleixner, Irina Mirkina, Sabine Cerny-Reiterer, Barbara Peter, Veronika Ferenc, Michael Kneidinger, Christian Baumgartner, Matthias Mayerhofer, Alexander Gruze, Winfried F. Pickl, Christian Sillaber, and Peter Valent
Blood 2009;114 5342-5351
http://bloodjournal.hematologylibrary.org/cgi/content/abstract/114/26/5342

VDAC2 is required for truncated BID-induced mitochondrial apoptosis by recruiting BAK to the mitochondria
Soumya Sinha Roy, Amy M Ehrlich, William J Craigen and György Hajnóczky
http://www.nature.com/embor/journal/v10/n12/abs/embor2009219.html

Voltage-dependent anion channel-1-based peptides interact with Bcl2 to prevent anti-apoptotic activity
Nir Arbel and Varda Shoshan-Barmatz
J. Biol. Chem. published 26 December 2009, 10.1074/jbc.M109.082990
http://www.jbc.org/cgi/content/abstract/M109.082990v1

Molecular details of Bax activation, oligomerization and membrane insertion
Stephanie Bleicken, Mirjam Classen, Pulagam V. L. Padmavathi, Takashi Ishikawa, Kornelius Zeth, Heinz-Jüergen Steinhoff, and Enrica Bordignon
J. Biol. Chem. published 13 December 2009, 10.1074/jbc.M109.081539
http://www.jbc.org/cgi/content/abstract/M109.081539v2

Vaccinia virus F1L interacts with Bak using highly divergent BCL-2 homology domains and replaces the function of Mcl-1
Stephanie Campbell, Bart Hazes, Marc Kvansakul, Peter Colman, and Michele Barry
J. Biol. Chem. published 2 December 2009, 10.1074/jbc.M109.053769
http://www.jbc.org/cgi/content/abstract/M109.053769v1

Bcl-xL changes conformation upon binding to wild-type but not mutant p53 DNA binding domain
Franz Hagn, Christian Klein, Oliver Demmer, Natasha Marchenko, Angelina Vaseva, Ute M. Moll, and Horst Kessler
J. Biol. Chem. published 2 December 2009, 10.1074/jbc.M109.065391
http://www.jbc.org/cgi/content/abstract/M109.065391v1
 

Death receptors and IAPs

Recruitment of the Linear Ubiquitin Chain Assembly Complex Stabilizes the TNF-R1 Signaling Complex and Is Required for TNF-Mediated Gene Induction
T.L. Haas, C.H. Emmerich, B. Gerlach, A.C. Schmukle, S.M. Cordier, E. Rieser, R. Feltham, J. Vince, U. Warnken, T. Wenger, R. Koschny, D. Komander, J. Silke, and H. Walczak
http://www.cell.com/molecular-cell/abstract/S1097-2765%2809%2900778-3

RIPK1 is not essential for TNFR1-induced activation of NF-B
W W-LWong, I E Gentle, U Nachbur, H Anderton, D L Vaux and J Silke
http://www.nature.com/cdd/journal/vaop/ncurrent/full/cdd2009178a.html

Cellular IAPs inhibit a cryptic CD95-induced cell death by limiting RIP1 kinase recruitment
Peter Geserick, Mike Hupe, Maryline Moulin, W. Wei-Lynn Wong, Maria Feoktistova, Beate Kellert, Harald Gollnick, John Silke, and Martin Leverkus
http://jcb.rupress.org/cgi/content/abstract/187/7/1037?etoc

Identification of an Xiap-Like Pseudogene on Mouse Chromosome 7
Aneta Kotevski, Wendy D. Cook, David L. Vaux, Bernard A. Callus
http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0008078

Modulation of Wnt signaling by the nuclear localization of cellular FLIP-L
Ryohei Katayama, Toshiyasu Ishioka, Shinji Takada, Ritsuko Takada, Naoya Fujita, Takashi Tsuruo, and Mikihiko Naito
J Cell Sci 2010;123 23-28
http://jcs.biologists.org/cgi/content/abstract/123/1/23

A Model of Partnership Co-Opted by the Homeodomain Protein TGIF and the Itch/AIP4 Ubiquitin Ligase for Effective Execution of TNF-α Cytotoxicity
C. Demange, N. Ferrand, C. Prunier, M.-F. Bourgeade, and A. Atfi
http://www.cell.com/molecular-cell/abstract/S1097-2765%2809%2900913-7
 

Caspases and downstream

Vaccinia Virus protein F1L is a caspase-9 inhibitor
Dayong Y. Zhai, Eric Yu, Chaofang Jin, Kate Welsh, Chung-wei Shiau, Lili Chen, Guy S. Salvesen, Robert Liddington, and John C. Reed
J. Biol. Chem. published 18 December 2009, 10.1074/jbc.M109.078113
http://www.jbc.org/cgi/content/abstract/M109.078113v1

Pretaporter, a Drosophila protein serving as a ligand for Draper in the phagocytosis of apoptotic cells
Takayuki Kuraishi, Yukiko Nakagawa, Kaz Nagaosa, Yumi Hashimoto, Takashi Ishimoto, Takeshi Moki, Yu Fujita, Hiroshi Nakayama, Naoshi Dohmae, Akiko Shiratsuchi, Naoko Yamamoto, Koichi Ueda, Masamitsu Yamaguchi, Takeshi Awasaki and Yoshinobu Nakanishi
http://www.nature.com/emboj/journal/v28/n24/abs/emboj2009343a.html

Annexin-II, DNA and histones serve as Factor H ligands on the surface of apoptotic cells
Jonatan Leffler, Andrew P. Herbert, Eva Norstrom, Chistoph Q. Schmidt, Paul N. Barlow, Anna M. Blom, and Myriam Martin
J. Biol. Chem. published 1 December 2009, 10.1074/jbc.M109.045427
http://www.jbc.org/cgi/content/abstract/M109.045427v1

 
Other

Inhibition of the ER Ca2+ pump forces multidrug-resistant cells deficient in Bak and Bax into necrosis
Katja Janssen, Sibylle Horn, Mathis T. Niemann, Peter T. Daniel, Klaus Schulze-Osthoff, and Ute Fischer
J Cell Sci 2009;122 4481-4491
http://jcs.biologists.org/cgi/content/abstract/122/24/4481

Yeast acetic acid-induced programmed cell death can occur without cytochrome c release which requires metacaspase YCA1
Nicoletta Guaragnella, Antonella Bobba, Salvatore Passarella, Ersilia Marra, Sergio Giannattasio
http://dx.doi.org/10.1016/j.febslet.2009.11.072
 
REVIEWS

A Tangled Web of Ubiquitin Chains: Breaking News in TNF-R1 Signaling
K. Bianchi and P. Meier
http://www.cell.com/molecular-cell/abstract/S1097-2765%2809%2900870-3

Mitochondrial cell death effectors
Dirk Brenner, Tak W Mak
http://dx.doi.org/10.1016/j.ceb.2009.09.009

Regulation of cell death by the ubiquitin–proteasome system
Maya Bader, Hermann Steller
http://dx.doi.org/10.1016/j.ceb.2009.09.005

Glucose metabolism and programmed cell death: an evolutionary and mechanistic perspective
Ayala King, Eyal Gottlieb
http://dx.doi.org/10.1016/j.ceb.2009.09.009

Caspase substrates: easily caught in deep waters?
Dieter Demon1, Petra Van Damme, Tom Vanden Berghe, Joël Vandekerckhove, Wim Declercq, Kris Gevaert and Peter Vandenabeele
http://dx.doi.org/10.1016/j.tibtech.2009.09.007

CDD: Special Issue on The Ubiquitin Proteasome System
http://www.nature.com/cdd/index.html

Including:

Regulation of TNFRSF and innate immune signalling complexes by TRAFs and cIAPs
J Silke and R Brink
http://www.nature.com/cdd/journal/v17/n1/full/cdd2009114a.html

The role of ubiquitylation for the control of cell death in Drosophila
A Bergmann
http://www.nature.com/cdd/journal/v17/n1/full/cdd200970a.html

 
COMMENTS

ER stress: another route to cell death
J Cell Sci 2009;122 e2401
http://jcs.biologists.org/cgi/content/full/122/24/e2401

Apoptosis: it’s BAK to VDAC
Gordon C. Shore
http://www.nature.com/embor/journal/v10/n12/full/embor2009249.html



Apolist – september 09

Caspases and downstream

Characterization of Cytoplasmic Caspase-2 Activation by Induced Proximity
L. Bouchier-Hayes, A. Oberst, G.P. McStay, S. Connell, S.W.G. Tait, C.P. Dillon, J.M. Flanagan, H.M. Beere, and D.R. Green
http://www.cell.com/molecular-cell/abstract/S1097-2765%2809%2900555-3

Caspase-8 deficiency in epidermal keratinocytes triggers an inflammatory skin disease
Andrew Kovalenko, Jin-Chul Kim, Tae-Bong Kang, Akhil Rajput, Konstantin Bogdanov, Oliver Dittrich-Breiholz, Michael Kracht, Ori Brenner, and David Wallach
http://jem.rupress.org/cgi/content/abstract/206/10/2161?etoc

Intracellular cleavage of osteopontin by caspase-8 modulates hypoxia/reoxygenation cell death through p53
Hyo-Jin Kim, Ho-June Lee, Joon-Il Jun, Yumin Oh, Seon-Guk Choi, Hyunjoo Kim, Chul-Woong Chung, In-Ki Kim, Il-Sun Park, Han-Jung Chae, Hyung-Ryong Kim, and Yong-Keun Jung
http://www.pnas.org/content/106/36/15326.abstract?etoc

Inhibition of human initiator caspase 8 and effector caspase 3 by cross-class inhibitory bovSERPINA3-1 and A3-3
Carlos H. Herrera-Mendez, Samira Becila, Xavier Blanchet, Patrick Pelissier, Didier Delourme, Gerald Coulis, Miguel A. Sentandreu, Abdelghani Boudjellal, Laure Bremaud, Ahmed Ouali
http://dx.doi.org/10.1016/j.febslet.2009.07.055

Caspase-2 Mediated Apoptotic and Necrotic Murine Macrophage Cell Death Induced by Rough Brucella abortus
Fang Chen, Yongqun He
http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0006830

The supernatant of apoptotic cells causes transcriptional activation of hypoxia-inducible factor–1 in macrophages via sphingosine-1-phosphate and transforming growth factor-β
Barbara Herr, Jie Zhou, Christian Werno, Heidi Menrad, Dmitry Namgaladze, Andreas Weigert, Nathalie Dehne, and Bernhard Brüne
http://bloodjournal.hematologylibrary.org/cgi/content/abstract/114/10/2140

Nucleotides released by apoptotic cells act as a find-me signal to promote phagocytic clearance
Michael R. Elliott1,2, Faraaz B. Chekeni1,3, Paul C. Trampont1,2, Eduardo R. Lazarowski7, Alexandra Kadl4, Scott F. Walk1,2, Daeho Park1,2, Robin I. Woodson5, Marina Ostankovich4, Poonam Sharma4, Jeffrey J. Lysiak5, T. Kendall Harden8, Norbert Leitinger3,4 & Kodi S. Ravichandran
http://www.nature.com/nature/journal/v461/n7261/full/nature08296.html

A new model for APAF-1’s transition from inactive monomer to caspase-activating apoptosome
Thomas F. Reubold, Sabine Wohlgemuth, and Susanne Eschenburg
J. Biol. Chem. published 30 September 2009, 10.1074/jbc.M109.014027
http://www.jbc.org/cgi/content/abstract/M109.014027v1

BH3

Identification of a Protein, G0S2, That Lacks Bcl-2 Homology Domains and Interacts with and Antagonizes Bcl-2
Christian Welch, Manas K. Santra, Wissal El-Assaad, Xiaochun Zhu, Wade E. Huber, Richard A. Keys, Jose G. Teodoro, and Michael R. Green
http://cancerres.aacrjournals.org/cgi/content/abstract/69/17/6782

Paclitaxel Directly Binds to Bcl-2 and Functionally Mimics Activity of Nur77
Cristiano Ferlini, Lucia Cicchillitti, Giuseppina Raspaglio, Silvia Bartollino, Samanta Cimitan, Carlo Bertucci, Simona Mozzetti, Daniela Gallo, Marco Persico, Caterina Fattorusso, Giuseppe Campiani, and Giovanni Scambia
http://cancerres.aacrjournals.org/cgi/content/abstract/69/17/6906

Conformational changes in BCL-2 pro-survival proteins determine their capacity to bind ligands
Erinna F. Lee, Peter E. Czabotar, Hong Yang, Brad E. Sleebs, Guillaume Lessene, Peter M. Colman, Brian J. Smith, and Walter Douglas Fairlie
J. Biol. Chem. published 2 September 2009, 10.1074/jbc.M109.040725
http://www.jbc.org/cgi/content/abstract/M109.040725v1

Mcl-1 degradation during hepatocyte lipoapoptosis
Howard C. Masuoka, Justin Mott, Steven F. Bronk, Nathan W. Werneburg, Yuko Akazawa, Scott H. Kaufmann, and Gregory J. Gores
J. Biol. Chem. published 5 September 2009, 10.1074/jbc.M109.039545
http://www.jbc.org/cgi/content/abstract/M109.039545v1

MCL-1ES, a novel variant of MCL-1, associates with MCL-1L and induces mitochondrial cell death
Jae-Hong Kim, Se-Hoon Sim, Hye-Jeong Ha, Jeong-Jae Ko, Kangseok Lee, Jeehyeon Bae
http://dx.doi.org/10.1016/j.febslet.2009.08.006

Toxoplasma gondii infection confers resistance against BimS-induced apoptosis by preventing the activation and mitochondrial targeting of pro-apoptotic Bax
Diana Hippe, Arnim Weber, Liying Zhou, Donald C. Chang, Georg Häcker, and Carsten G. K. Lüder
J Cell Sci 2009;122 3511-3521
http://jcs.biologists.org/cgi/content/abstract/122/19/3511

Carboxy-terminal residues regulate localization and function of the antiapoptotic protein Bfl-1
Gaelle Brien, Anne-Laure Debaud, Xavier Robert, Lisa Oliver, Marie-Claude Trescol-Biemont, Nicolas Cauquil, Olivier Geneste, Nushin Agahajari, Francois M. Vallette, Richard Haser, and Nathalie Bonnefoy-Berard
http://www.jbc.org/cgi/content/abstract/M109.040824v1

Novel BCL-2 homology (BH)-3 domain-like sequences identified from screening randomized peptide libraries for inhibitors of the pro-survival BCL 2 proteins
Erinna F. Lee, Anna Fedorova, Kerry Zobel, Michelle J. Boyle, Hong Yang, Matthew A. Perugini, Peter M. Colman, David C. S. Huang, Kurt Deshayes, and Walter Douglas Fairlie
http://www.jbc.org/cgi/content/abstract/M109.048009v1

p16INK4A sensitizes human leukemia cells to FAS- and glucocorticoid-induced apoptosis via induction of BBC3/Puma and repression of MCL1 and BCL2
Petra Obexer, Judith Hagenbuchner, Martina Rupp, Christina Salvador, Markus Holzner, Martin Deutsch, Verena Porto, Reinhard Kofler, Thomas Unterkirchner, and Michael J. Ausserlechner
J. Biol. Chem. published 8 September 2009, 10.1074/jbc.M109.051441
http://www.jbc.org/cgi/content/abstract/M109.051441v2

Death receptors

Membrane-bound Fas ligand only is essential for Fas-induced apoptosis
Lorraine A. O’ Reilly1, Lin Tai1, Lily Lee1, Elizabeth A. Kruse1,2, Stephanie Grabow1,2, W. Douglas Fairlie1, Nicole M. Haynes3, David M. Tarlinton1, Jian-Guo Zhang1, Gabrielle T. Belz1, Mark J. Smyth3, Philippe Bouillet1, Lorraine Robb1 & Andreas Strasser
http://www.nature.com/nature/journal/v461/n7264/full/nature08402.html

Involvement of mitochondria and recruitment of Fas/CD95 signaling in lipid rafts in resveratrol-mediated antimyeloma and antileukemia actions
M Reis-Sobreiro, C Gajate and F Mollinedo
http://www.nature.com/onc/journal/v28/n36/full/onc2009183a.html

Procaspase 8 overexpression in non-small-cell lung cancer promotes apoptosis induced by FLIP silencing
T R Wilson, K M Redmond, K M McLaughlin, N Crawford, K Gately, K O’Byrne, C Le-Clorrenec, C Holohan, D A Fennell, P G Johnston and D B Longley
http://www.nature.com/cdd/journal/v16/n10/full/cdd200976a.html#bib11

Histone deacetylase inhibitors cooperate with IFN- to restore caspase-8 expression and overcome TRAIL resistance in cancers with silencing of caspase-8
S Häcker, A Dittrich, A Mohr, T Schweitzer, S Rutkowski, J Krauss, K-M Debatin and S Fulda
http://www.nature.com/onc/journal/v28/n35/full/onc2009161a.html

Caspase-9 activation by the apoptosome is not required for fas-mediated apoptosis in type II jurkat cells
Mary E. Shawgo, Shary N. Shelton, and John D. Robertson
http://www.jbc.org/cgi/content/abstract/M109.032359v1

Other

Expression, purification and use of recombinant annexin V for the detection of apoptotic cells
Susan E Logue, Mohamed Elgendy & Seamus J Martin
http://www.nature.com/nprot/journal/v4/n9/full/nprot.2009.143.html

c-Jun NH2-Terminal Kinase Activation Is Essential for DRAM-Dependent Induction of Autophagy and Apoptosis in 2-Methoxyestradiol–Treated Ewing Sarcoma Cells
Séverine Lorin, Amélie Borges, Lisandra Ribeiro Dos Santos, Sylvie Souquère, Gérard Pierron, Kevin M. Ryan, Patrice Codogno, and Mojgan Djavaheri-Mergny
Cancer Res 2009;69 6924-6931
http://cancerres.aacrjournals.org/cgi/content/abstract/69/17/6924

Interfering with multimerization of netrin-1 receptors triggers tumor cell death
F Mille, F Llambi, C Guix, C Delloye-Bourgeois, C Guenebeaud, S Castro-Obregon, D E Bredesen, C Thibert and P Mehlen
http://www.nature.com/cdd/journal/v16/n10/full/cdd200975a.html

REVIEWS / COMMENTS

Caspase-2: killer, savior and safeguard—emerging versatile roles for an ill-defined caspase
G Krumschnabel, C Manzl and A Villunger
http://www.nature.com/onc/journal/v28/n35/full/onc2009173a.html

Caspases and Kinases in a Death Grip
Manabu Kurokawa, Sally Kornbluth
http://dx.doi.org/10.1016/j.cell.2009.08.021

Lots of reviews on autophagy (and autophagic cell death) in BBA-Molecular Cell Research:
http://www.sciencedirect.com/science/issue/4904-2009-982069990-1484090

A Cut Above the Other Caspases
J.L. Andersen and S. Kornbluth
http://www.cell.com/molecular-cell/abstract/S1097-2765%2809%2900629-7

Cell biology: Sent by the scent of death
Christopher Gregory
http://www.nature.com/nature/journal/v461/n7261/full/461181a.html

Apolist – august 09

This month we have a whole issue dedicated to reviews on BH3-only proteins in Oncogene:
http://www.nature.com/onc/journal/v27/n1s/index.html

And a whole issue of Apoptosis (the journal) dedicated to death in Drosophila
http://www.springerlink.com/content/r74684125h61/?p=c3a75d05149c4479a014c83ca0a4e1a9&pi=0


Death receptors

Reconstitution of the Death-Inducing Signaling Complex Reveals a Substrate Switch that Determines CD95-Mediated Death or Survival
M.A. Hughes, N. Harper, M. Butterworth, K. Cain, G.M. Cohen, and M. MacFarlane
http://www.cell.com/molecular-cell/abstract/S1097-2765(09)00423-7
PMID: 19683492

A New C-Terminal Cleavage Product of Procaspase-8, p30, Defines an Alternative Pathway of Procaspase-8 Activation
Julia C. Hoffmann, Alexander Pappa, Peter H. Krammer, and Inna N. Lavrik
http://mcb.asm.org/cgi/content/abstract/29/16/4431

AIMP2 promotes TNF-dependent apoptosis via ubiquitin-mediated degradation of TRAF2
Jin Woo Choi, Dae Gyu Kim, Min Chul Park, Jung Yeon Um, Jung Min Han, Sang Gyu Park, Eung-Chil Choi, and Sunghoon Kim
http://jcs.biologists.org/cgi/content/abstract/122/15/2710

PKC-mediated phosphorylation regulates c-FLIP ubiquitylation and stability
A Kaunisto, V Kochin, T Asaoka, A Mikhailov, M Poukkula, A Meinander & J E Eriksson
http://www.nature.com/cdd/journal/v16/n9/full/cdd200935a.html

The Tumor Suppressor Par-4 Activates an Extrinsic Pathway for Apoptosis
Ravshan Burikhanov, Yanming Zhao, Anindya Goswami, Shirley Qiu, Steven R. Schwarze, Vivek M. Rangnekar
http://dx.doi.org/10.1016/j.cell.2009.05.022

The pleiotropic effect of TRAIL on tumor-like synovial fibroblasts from rheumatoid arthritis patients is mediated by caspases
R Audo, B Combe, B Coulet, J Morel & M Hahne
http://www.nature.com/cdd/journal/v16/n9/full/cdd200938a.html



BH3

The role of BH3-only protein Bim extends beyond inhibiting Bcl-2-like prosurvival proteins
Delphine Mérino, Maybelline Giam, Peter D. Hughes, Owen M. Siggs, Klaus Heger, Lorraine A. O’Reilly, Jerry M. Adams, Andreas Strasser, Erinna F. Lee, Walter D. Fairlie, and Philippe Bouillet
http://jcb.rupress.org/cgi/content/abstract/186/3/355?etoc

The BH4 domain of Bcl-2 inhibits ER calcium release and apoptosis by binding the regulatory and coupling domain of the IP3 receptor
Yi-Ping Rong, Geert Bultynck, Ademuyiwa S. Aromolaran, Fei Zhong, Jan B. Parys, Humbert De Smedt, Gregory A. Mignery, H. Llewelyn Roderick, Martin D. Bootman, and Clark W. Distelhorst
http://www.pnas.org/content/106/34/14397.abstract?etoc

Differentiation-Related Gene-1 Decreases Bim Stability by Proteasome-Mediated Degradation
Grazia Ambrosini, Sharon L. Seelman, and Gary K. Schwartz
http://cancerres.aacrjournals.org/cgi/content/abstract/69/15/6115

Cell type-dependent proapoptotic role of Bcl2L12 revealed by a mutation concomitant with the disruption of the juxtaposed Irf3 gene
Akira Nakajima, Keishiro Nishimura, Yukana Nakaima, Tomohiko Oh, Shigeru Noguchi, Tadatsugu Taniguchi, and Tomohiko Tamura
http://www.pnas.org/content/106/30/12448.long

RNA Silencing of Mcl-1 Enhances ABT-737-Mediated Apoptosis in Melanoma: Role for a Caspase-8-Dependent Pathway
Angela M. Keuling, Kathleen E. A. Felton, Arabesque A. M. Parker, Majid Akbari, Susan E. Andrew, Victor A. Tron
http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0006651

Forodesine has high antitumor activity in chronic lymphocytic leukemia and activates p53-independent mitochondrial apoptosis by induction of p73 and BIM
Roberto Alonso, Mónica López-Guerra, Ramanda Upshaw, Shanta Bantia, Caroline Smal, Françoise Bontemps, Chantal Manz, Thomas Mehrling, Neus Villamor, Elias Campo, Emili Montserrat, and Dolors Colomer
http://bloodjournal.hematologylibrary.org/cgi/content/abstract/114/8/1563

Identification of novel in vivo phosphorylation sites of the human pro-apoptotic protein bad: pore-forming activity of bad is regulated by phosphorylation
Lisa Polzien, Angela Baljuls, Ulrike E. E. Rennefahrt, Andreas Fischer, Werner Schmitz, Rene P. Zahedi, Albert Sickmann, Renate Metz, Stefan Albert, Roland Benz, Mirko Hekman, and Ulf R. Rapp
http://www.jbc.org/cgi/content/abstract/M109.010702v1

JNK1-dependent PUMA expression contributes to hepatocyte lipoapoptosis
Sophie C. Cazanave, Justin L. Mott, Nafisa A. Elmi, Steven F. Bronk, Nathan W. Werneburg, Yuko Akazawa, Alisan Kahraman, Sean P. Garrison, Gerard P. Zambetti, Michael R. Charlton, and Gregory J. Gores
http://www.jbc.org/cgi/content/abstract/M109.022491v1

The BCL-2-like protein CED-9 of C. elegans promotes FZO-1/Mfn1,2- and EAT-3/Opa1-dependent mitochondrial fusion
Stéphane G. Rolland, Yun Lu, Charles N. David, and Barbara Conradt
http://jcb.rupress.org/cgi/content/abstract/186/4/525?etoc

PUMA is directly activated by NF-B and contributes to TNF–induced apoptosis
P Wang, W Qiu, C Dudgeon, H Liu, C Huang, G P Zambetti, J Yu & L Zhang
http://www.nature.com/cdd/journal/v16/n9/full/cdd200951a.html



IMMUNITY

The caspase-cleaved form of LYN mediates a psoriasis-like inflammatory syndrome in mice
SandrineMarchetti, Parvati Gamas, Nathalie Belhacène, Sebastien Grosso, Ludivine A Pradelli, Pascal Colosetti, Claus Johansen, Lars Iversen, Marcel Deckert, Fréderic Luciano, Paul Hofman, Nicolas Ortonne, Abdallah Khemis, Bernard Mari, Jean-Paul Ortonne, Jean-Ehrland Ricci and Patrick Auberger
http://www.nature.com/emboj/journal/v28/n16/full/emboj2009183a.html

The VDAC2-BAK Rheostat Controls Thymocyte Survival
Decheng Ren, Hyungjin Kim, Ho-Chou Tu, Todd D. Westergard, Jill K. Fisher, Jeff A. Rubens, Stanley J. Korsmeyer, James J.-D. Hsieh, and Emily H.-Y. Cheng
http://stke.sciencemag.org/cgi/content/abstract/sigtrans;2/85/ra48?etoc

Apoptotic Cells Promote Their Own Clearance and Immune Tolerance through Activation of the Nuclear Receptor LXR
N. A-Gonzalez, S.J. Bensinger, C. Hong, S. Beceiro, M.N. Bradley, N. Zelcer, J. Deniz, C. Ramirez, M. D_iaz, G. Gallardo, C. Ruiz de Galarreta, J. Salazar, F. Lopez, P. Edwards, J. Parks, M. Andujar, P. Tontonoz, and A. Castrillo
http://www.cell.com/immunity/abstract/S1074-7613%2809%2900318-5

XIAP mediates NOD signaling via interaction with RIP2
Andreas Krieg, Ricardo G. Correa, Jason B. Garrison, Gaëlle Le Negrate, Kate Welsh, Ziwei Huang, Wolfram T. Knoefel, and John C. Reed
http://www.pnas.org/cgi/content/abstract/106/34/14524?etoc



Caspases and downstream

Suicidal Membrane Repair Regulates Phosphatidylserine Externalization during Apoptosis
Banafsheh Mirnikjoo, Krishnakumar Balasubramanian, and Alan J. Schroit
http://www.jbc.org/cgi/content/abstract/284/34/22512
PMID: 19561081

Several Nuclear Events during Apoptosis Depend on Caspase-3 Activation but Do Not Constitute a Common Pathway
Lisa Trisciuoglio, Marco Emilio Bianchi
http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0006234





REVIEWS / COMMENTS

Live to dead cell imaging.
Tait SW, Bouchier-Hayes L, Oberst A, Connell S, Green DR.
http://www.springerlink.com/content/v8wk3h734552v330/
PMID: 19609747

Mechanisms by which Bak and Bax permeabilise mitochondria during apoptosis
Grant Dewson and Ruth M. Kluck
http://jcs.biologists.org/cgi/content/abstract/122/16/2801

Human Caspases: Activation, Specificity, and Regulation
Cristina Pop and Guy S. Salvesen
http://www.jbc.org/cgi/content/abstract/284/33/21777

Lysosomes as “Suicide Bags” in Cell Death: Myth or Reality?
Boris Turk and Vito Turk
http://www.jbc.org/cgi/content/full/284/33/21783

Bax activation by Bim?
P E Czabotar, P M Colman & D C S Huang
http://www.nature.com/cdd/journal/v16/n9/full/cdd200983a.html

Cell Death: A New Par-4 the TRAIL
Lori S. Hart, Wafik S. El-Deiry
http://dx.doi.org/10.1016/j.cell.2009.07.007

RIP Kinases at the Crossroads of Cell Death and Survival p229
Wim Declercq, Tom Vanden Berghe, Peter Vandenabeele
http://dx.doi.org/10.1016/j.cell.2009.07.006

SnapShot: BCL-2 Proteins
J. Marie Hardwick, Richard J. Youle
http://download.cell.com/pdf/PIIS0092867409008393.pdf

Mitochondrial calcium and the permeability transition in cell death
John J. Lemasters, Tom P. Theruvath, Zhi Zhong, Anna-Liisa Nieminen
http://dx.doi.org/10.1016/j.bbabio.2009.06.009

When Repair Is Suicide
Nancy R. Gough
http://stke.sciencemag.org/cgi/content/abstract/sigtrans;2/85/ec283?etoc

Repairing to Destroy: Suicidal Membrane Repair Regulates Phosphatidylserine Externalization during Apoptosis
http://www.jbc.org/cgi/content/full/284/34/e99939

Cardiolipin-enriched raft-like microdomains are essential activating platforms for apoptotic signals on mitochondria
Maurizio Sorice, Valeria Manganelli, Paola Matarrese, Antonella Tinari, Roberta Misasi, Walter Malorni, Tina Garofalo
http://www.febsletters.org/article/S0014-5793(09)00545-6/abstract



Plenty of reviews in Oncogene and Apoptosis. Just a few samples:

BH3-only proteins in apoptosis and beyond: an overview
E Lomonosova & G Chinnadurai
http://www.nature.com/onc/journal/v27/n1s/full/onc200939a.html

Noxa: at the tip of the balance between life and death
C Ploner, R Kofler & A Villunger
http://www.nature.com/onc/journal/v27/n1s/full/onc200946a.html

Bim and Bmf in tissue homeostasis and malignant disease.
Piñon JD, Labi V, Egle A, Villunger A.
http://www.nature.com/onc/journal/v27/n1s/full/onc200942a.html
PMID: 19641506

Inhibitor of apoptosis proteins in Drosophila: gatekeepers of death
Mariam Orme and Pascal Meier
http://www.springerlink.com/content/p021j271r1772362/fulltext.html



Other


Death on the slopes. Symposium on Cell Death Pathways
Christina K McPhee, Jahda H Hill & Mari Enoksson
http://www.nature.com/embor/journal/v10/n8/full/embor2009160.html
[about Keystone meeting in Whistler]

Latest Science/AAAS Webinar: Apoptotic Signaling in Normal and Cancer
Cell Biology, – September, 22 2009, at 12 noon Eastern Time (9 a.m.
Pacific, 4 p.m. GMT)
Register TODAY: www.sciencemag.org/webinar

Apolist – july 2009

Death receptors and IAPs

XIAP discriminates between type I and type II FAS-induced apoptosis
Philipp J. Jost, Stephanie Grabow1,2, Daniel Gray1, Mark D. McKenzie2,3, Ueli Nachbur4, David C. S. Huang1, Philippe Bouillet, Helen E. Thomas3, Christoph Borner, John Silke, Andreas Strasser & Thomas Kaufmann1
http://www.nature.com/nature/journal/vaop/ncurrent/full/nature08229.html#B19
PMID 19626005

RIP3, an Energy Metabolism Regulator That Switches TNF-Induced Cell Death from Apoptosis to Necrosis
D.-W. Zhang et al.
http://www.sciencemag.org/cgi/content/abstract/325/5938/332
PMID 19498109

A single nucleotide polymorphism determines protein isoform production of the human c-FLIP protein
Nana Ueffing, Kusum K. Singh, Andrea Christians, Christoph Thorns, Alfred C. Feller, Florian Nagl, Falko Fend, Sebastian Heikaus, Alexander Marx, Rainer B. Zotz, Joachim Brade, Wolfgang A. Schulz, Klaus Schulze-Osthoff, Ingo Schmitz, and Christian Schwerk
http://bloodjournal.hematologylibrary.org/cgi/content/abstract/114/3/572

X-linked Inhibitor of Apoptosis Protein (XIAP) Regulates PTEN Ubiquitination, Content, and Compartmentalization
Céline Van Themsche, Valérie Leblanc, Sophie Parent, and Eric Asselin
http://www.jbc.org/cgi/content/abstract/284/31/20462


Caspases

Suppression of Interleukin-33 Bioactivity through Proteolysis by Apoptotic Caspases
Alexander U. Lüthi, Sean P. Cullen, Edel A. McNeela, Patrick J. Duriez, Inna S. Afonina, Clare Sheridan, Gabriela Brumatti, Rebecca C. Taylor, Kristof Kersse, Peter Vandenabeele, Ed C. Lavelle, Seamus J. Martin
http://www.cell.com/immunity/abstract/S1074-7613(09)00269-6

The Apaf-1-procaspase-9 apoptosome complex functions as a proteolytic-based molecular timer
Srinivas Malladi, Madhavi Challa-Malladi, Howard O Fearnhead and Shawn B Bratton
http://www.nature.com/emboj/journal/v28/n13/full/emboj2009152a.html

Dissecting an allosteric switch in caspase-7 using chemical and mutational probes
Jeanne A. Hardy and James A. Wells
http://www.jbc.org/cgi/content/abstract/M109.001826v1

Calpain-1 cleaves and activates caspase-7
Juliette Gafni, Xin Cong, Sylvia F. Chen, Bradford W. Gibson, and Lisa M. Ellerby
http://www.jbc.org/cgi/content/abstract/M109.038174v2

Genetic variation in caspase genes and risk of non-Hodgkin lymphoma: a pooled analysis of 3 population-based case-control studies
Qing Lan, Lindsay M. Morton, Bruce Armstrong2, Patricia Hartge1, Idan Menashe1, Tongzhang Zheng3, Mark P. Purdue1, James R. Cerhan4, Yawei Zhang3, Andrew Grulich5, Wendy Cozen6, Meredith Yeager7, Theodore R. Holford3, Claire M. Vajdic8, Scott Davis9, Brian Leaderer3, Anne Kricker2, Maryjean Schenk10, Shelia H. Zahm1, Nilanjan Chatterjee1, Stephen J. Chanock1,7, Nathaniel Rothman1, and Sophia S. Wang
http://bloodjournal.hematologylibrary.org/cgi/content/abstract/114/2/264?etoc


BH3

PUMA Promotes Bax Translocation by Both Directly Interacting with Bax and by Competitive Binding to Bcl-XL during UV-induced Apoptosis
Yingjie Zhang, Da Xing, and Lei Liu
http://www.molbiolcell.org/cgi/content/abstract/20/13/3077?etoc

Detergent activated BAX protein is a monomer
Olena Ivashyna, Ana J. Garcia-Saez, Jonas Ries, Eric T. Christenson, Petra Schwille, and Paul H. Schlesinger
http://www.jbc.org/cgi/content/abstract/M109.023853v1

PUMA- and Bax-induced autophagy contributes to apoptosis
K S Yee, S Wilkinson, J James, K M Ryan & K H Vousden
http://www.nature.com/cdd/journal/v16/n8/full/cdd200944a.html

MAP4K3 modulates cell death via the post-transcriptional regulation of BH3-only proteins
David Lam, David Dickens, Elizabeth B. Reid, Samantha H. Y. Loh, Nicoleta Moisoi, and L. Miguel Martins
http://www.pnas.org/content/106/29/11978.abstract?etoc


Other

MDM4 (MDMX) localizes at the mitochondria and facilitates the p53-mediated intrinsic-apoptotic pathway
Francesca Mancini, Giusy Di Conza, Marsha Pellegrino, Cinzia Rinaldo, Andrea Prodosmo, Simona Giglio, Igea D’Agnano, Fulvio Florenzano, Lara Felicioni, Fiamma Buttitta, Antonio Marchetti, Ada Sacchi, Alfredo Pontecorvi, Silvia Soddu and Fabiola Moretti
http://www.nature.com/emboj/journal/v28/n13/full/emboj2009154a.html

A novel role for MAP1 LC3 in nonautophagic cytoplasmic vacuolation death of cancer cells
R Kar, P K Singha, M A Venkatachalam & P Saikumar
http://www.nature.com/onc/journal/v28/n28/full/onc2009118a.html


REVIEWS / COMMENTS

Guidelines for the use and interpretation of assays for monitoring cell death in higher eukaryotes
(plenty of authors)
http://www.nature.com/cdd/journal/v16/n8/full/cdd200944a.html

BCL2DB: moving ‘helix-bundled’ BCL-2 family members to their database
Stanislas Valentin Blaineau, Abdel Aouacheria
http://www.springerlink.com/content/j6x5l4117x50ph7m/

IL-33 Raises Alarm
M. Lamkanfi and V.M. Dixit
http://www.cell.com/immunity/abstract/S1074-7613(09)00284-2

Mitochondrial targeting of tBid/Bax: a role for the TOM complex?
M Ott, E Norberg, B Zhivotovsky & S Orrenius
http://www.nature.com/cdd/journal/v16/n8/full/cdd200961a.html

Caspase-8 for Outer Harmony
Gabriel Sollberger and Hans-Dietmar Beer
http://stke.sciencemag.org/cgi/content/abstract/sigtrans;2/78/pe40?etoc

Caspase-2: controversial killer or checkpoint controller?
Tanja Kitevska, Damian M. S. Spencer, Christine J. Hawkins
http://www.springerlink.com/content/q88h871q37540753/

Death receptors and IAPs

XIAP discriminates between type I and type II FAS-induced apoptosis

Philipp J. Jost, Stephanie Grabow1,2, Daniel Gray1, Mark D. McKenzie2,3, Ueli Nachbur4, David C. S. Huang1, Philippe Bouillet, Helen E. Thomas3, Christoph Borner, John Silke, Andreas Strasser & Thomas Kaufmann1

http://www.nature.com/nature/journal/vaop/ncurrent/full/nature08229.html#B19

PMID 19626005

RIP3, an Energy Metabolism Regulator That Switches TNF-Induced Cell Death from Apoptosis to Necrosis

D.-W. Zhang et al.

http://www.sciencemag.org/cgi/content/abstract/325/5938/332

PMID 19498109

A single nucleotide polymorphism determines protein isoform production of the human c-FLIP protein

Nana Ueffing, Kusum K. Singh, Andrea Christians, Christoph Thorns, Alfred C. Feller, Florian Nagl, Falko Fend, Sebastian Heikaus, Alexander Marx, Rainer B. Zotz, Joachim Brade, Wolfgang A. Schulz, Klaus Schulze-Osthoff, Ingo Schmitz, and Christian Schwerk

http://bloodjournal.hematologylibrary.org/cgi/content/abstract/114/3/572

X-linked Inhibitor of Apoptosis Protein (XIAP) Regulates PTEN Ubiquitination, Content, and Compartmentalization

Céline Van Themsche, Valérie Leblanc, Sophie Parent, and Eric Asselin

http://www.jbc.org/cgi/content/abstract/284/31/20462

Caspases

Suppression of Interleukin-33 Bioactivity through Proteolysis by Apoptotic Caspases

Alexander U. Lüthi, Sean P. Cullen, Edel A. McNeela, Patrick J. Duriez, Inna S. Afonina, Clare Sheridan, Gabriela Brumatti, Rebecca C. Taylor, Kristof Kersse, Peter Vandenabeele, Ed C. Lavelle, Seamus J. Martin

http://www.cell.com/immunity/abstract/S1074-7613(09)00269-6

The Apaf-1-procaspase-9 apoptosome complex functions as a proteolytic-based molecular timer

Srinivas Malladi, Madhavi Challa-Malladi, Howard O Fearnhead and Shawn B Bratton

http://www.nature.com/emboj/journal/v28/n13/full/emboj2009152a.html

Dissecting an allosteric switch in caspase-7 using chemical and mutational probes

Jeanne A. Hardy and James A. Wells

http://www.jbc.org/cgi/content/abstract/M109.001826v1

Calpain-1 cleaves and activates caspase-7

Juliette Gafni, Xin Cong, Sylvia F. Chen, Bradford W. Gibson, and Lisa M. Ellerby

http://www.jbc.org/cgi/content/abstract/M109.038174v2

Genetic variation in caspase genes and risk of non-Hodgkin lymphoma: a pooled analysis of 3 population-based case-control studies

Qing Lan, Lindsay M. Morton, Bruce Armstrong2, Patricia Hartge1, Idan Menashe1, Tongzhang Zheng3, Mark P. Purdue1, James R. Cerhan4, Yawei Zhang3, Andrew Grulich5, Wendy Cozen6, Meredith Yeager7, Theodore R. Holford3, Claire M. Vajdic8, Scott Davis9, Brian Leaderer3, Anne Kricker2, Maryjean Schenk10, Shelia H. Zahm1, Nilanjan Chatterjee1, Stephen J. Chanock1,7, Nathaniel Rothman1, and Sophia S. Wang

http://bloodjournal.hematologylibrary.org/cgi/content/abstract/114/2/264?etoc

BH3

PUMA Promotes Bax Translocation by Both Directly Interacting with Bax and by Competitive Binding to Bcl-XL during UV-induced Apoptosis

Yingjie Zhang, Da Xing, and Lei Liu

http://www.molbiolcell.org/cgi/content/abstract/20/13/3077?etoc

Detergent activated BAX protein is a monomer

Olena Ivashyna, Ana J. Garcia-Saez, Jonas Ries, Eric T. Christenson, Petra Schwille, and Paul H. Schlesinger

http://www.jbc.org/cgi/content/abstract/M109.023853v1

PUMA- and Bax-induced autophagy contributes to apoptosis

K S Yee, S Wilkinson, J James, K M Ryan & K H Vousden

http://www.nature.com/cdd/journal/v16/n8/full/cdd200944a.html

MAP4K3 modulates cell death via the post-transcriptional regulation of BH3-only proteins

David Lam, David Dickens, Elizabeth B. Reid, Samantha H. Y. Loh, Nicoleta Moisoi, and L. Miguel Martins

http://www.pnas.org/content/106/29/11978.abstract?etoc

Other

MDM4 (MDMX) localizes at the mitochondria and facilitates the p53-mediated intrinsic-apoptotic pathway

Francesca Mancini, Giusy Di Conza, Marsha Pellegrino, Cinzia Rinaldo, Andrea Prodosmo, Simona Giglio, Igea D’Agnano, Fulvio Florenzano, Lara Felicioni, Fiamma Buttitta, Antonio Marchetti, Ada Sacchi, Alfredo Pontecorvi, Silvia Soddu and Fabiola Moretti

http://www.nature.com/emboj/journal/v28/n13/full/emboj2009154a.html

A novel role for MAP1 LC3 in nonautophagic cytoplasmic vacuolation death of cancer cells

R Kar, P K Singha, M A Venkatachalam & P Saikumar

http://www.nature.com/onc/journal/v28/n28/full/onc2009118a.html

REVIEWS / COMMENTS

Guidelines for the use and interpretation of assays for monitoring cell death in higher eukaryotes

(plenty of authors)

http://www.nature.com/cdd/journal/v16/n8/full/cdd200944a.html

BCL2DB: moving ‘helix-bundled’ BCL-2 family members to their database

Stanislas Valentin Blaineau, Abdel Aouacheria

http://www.springerlink.com/content/j6x5l4117x50ph7m/

IL-33 Raises Alarm

M. Lamkanfi and V.M. Dixit

http://www.cell.com/immunity/abstract/S1074-7613(09)00284-2

Mitochondrial targeting of tBid/Bax: a role for the TOM complex?

M Ott, E Norberg, B Zhivotovsky & S Orrenius

http://www.nature.com/cdd/journal/v16/n8/full/cdd200961a.html

Caspase-8 for Outer Harmony

Gabriel Sollberger and Hans-Dietmar Beer

http://stke.sciencemag.org/cgi/content/abstract/sigtrans;2/78/pe40?etoc

Caspase-2: controversial killer or checkpoint controller?

Tanja Kitevska, Damian M. S. Spencer, Christine J. Hawkins

http://www.springerlink.com/content/q88h871q37540753/

Apolist – june 2009

Genome-wide silencing in Drosophila captures conserved apoptotic effectors
Su Kit Chew et al.
http://www.nature.com/nature/journal/vaop/ncurrent/full/nature08087.html


Death receptors and IAPs

Receptor Interacting Protein Kinase-3 Determines Cellular Necrotic Response to TNF-α
S. He, L. Wang, L. Miao, T. Wang, F. Du, L. Zhao, and X. Wang
http://www.cell.com/abstract/S0092-8674%2809%2900578-9

Phosphorylation-Driven Assembly of the RIP1-RIP3 Complex Regulates Programmed Necrosis and Virus-Induced Inflammation
Y.S. Cho, S. Challa, D. Moquin, R. Genga, T.D. Ray, M. Guildford, and F.K.-M. Chan
http://www.cell.com/abstract/S0092-8674%2809%2900642-4

Phenylarsine oxide interferes with the death inducing signaling complex and inhibits tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) induced apoptosis.
Sun XM, Canda-Sánchez A, Manjeri GR, Cohen GM, Pinkoski MJ.
http://dx.doi.org/10.1016/j.yexcr.2009.05.014

TAK1 kinase determines TRAIL sensitivity by modulating reactive oxygen species and cIAP
S Morioka, E Omori, T Kajino, R Kajino-Sakamoto, K Matsumoto & J Ninomiya-Tsuji
http://www.nature.com/onc/journal/v28/n23/full/onc2009110a.html

CD95 co-stimulation blocks activation of naive T cells by inhibiting T cell receptor signaling
Gudrun Strauss, Jonathan A. Lindquist, Nathalie Arhel, Edward Felder, Sabine Karl, Tobias L. Haas, Simone Fulda, Henning Walczak, Frank Kirchhoff, and Klaus-Michael Debatin
http://jem.rupress.org/cgi/content/abstract/206/6/1379?etoc

Cytotoxicity mediated by the FASL-activated apoptotic pathway in stem cells
Julia Mazar, Molly Thomas, Ludmila Bezrukov, Alexander Chanturia, Gulcin Pekkurnaz, Shurong Yin, Sergei A. Kuznetsov, Pamela Gehron Robey, and Joshua Zimmerberg
http://www.jbc.org/cgi/content/abstract/M109.032235v1


BH3

Mitochondrial apoptosis induced by BH3-only molecules in the exclusive presence of endoplasmic reticular Bak
Martina Klee, Kathrin Pallauf, Sonia Alcalá, Aarne Fleischer and Felipe X Pimentel-Muiños
http://www.nature.com/emboj/journal/v28/n12/abs/emboj200990a.html

KLF6-SV1 Is a Novel Antiapoptotic Protein That Targets the BH3-Only Protein NOXA for Degradation and Whose Inhibition Extends Survival in an Ovarian Cancer Model
Analisa DiFeo, Fei Huang, Jaya Sangodkar, Esteban A. Terzo, Devin Leake, Goutham Narla, and John A. Martignetti
http://cancerres.aacrjournals.org/cgi/content/abstract/69/11/4733

Acetylation of the DNA binding domain regulates transcription-independent apoptosis by p53
Stephen M. Sykes, Timothy J. Stanek, Amanda Frank, Maureen E. Murphy, and Steven B. McMahon
http://www.jbc.org/cgi/content/abstract/M109.026096v1

BimL directly neutralizes Bcl-xL to promote Bax activation during UV-induced apoptosis
Xianwang Wang, Da Xing, Lei Liu, Wei R. Chen
http://dx.doi.org/10.1016/j.febslet.2009.04.045

PUMA Suppresses Intestinal Tumorigenesis in Mice
Wei Qiu, Eleanor B. Carson-Walter, Shih Fan Kuan, Lin Zhang, and Jian Yu
http://cancerres.aacrjournals.org/cgi/content/abstract/69/12/4999

PUMA mediates EGFR tyrosine kinase inhibitor-induced apoptosis in head and neck cancer cells
Q Sun, L Ming, S M Thomas, Y Wang, Z G Chen, R L Ferris, J R Grandis, L Zhang & J Yu
http://www.nature.com/onc/journal/v28/n24/full/onc2009108a.html

Different forms of cell death induced by putative BCL2 inhibitors
M Vogler, K Weber, D Dinsdale, I Schmitz, K Schulze-Osthoff, M J S Dyer & G M Cohen
http://www.nature.com/cdd/journal/v16/n7/full/cdd200948a.html

Mcl-1 Integrates the Opposing Actions of Signaling Pathways That Mediate Survival and Apoptosis
Caroline Morel, Scott M. Carlson, Forest M. White, and Roger J. Davis
http://mcb.asm.org/cgi/content/abstract/29/14/3845

Adenine Nucleotide Translocator Cooperates with Core Cell Death Machinery To Promote Apoptosis in Caenorhabditis elegans
Qinfang Shen, Fengsong Qin, Zhiyang Gao, Jie Cui, Hui Xiao, Zhiheng Xu, and Chonglin Yang
http://mcb.asm.org/cgi/content/abstract/29/14/3881


IAPs, caspases and downstream

Cellular Inhibitors of Apoptosis cIAP1 and cIAP2 Are Required for Innate Immunity Signaling by the Pattern Recognition Receptors NOD1 and NOD2
M.J.M. Bertrand, K. Doiron, K. Labb_e, R.G. Korneluk, P.A. Barker, and M. Saleh
http://dx.doi.org/10.1016/j.immuni.2009.04.011

Gender differences in expression of the human caspase-12 long variant determines susceptibility to Listeria monocytogenes infection
Garabet Yeretssian, Karine Doiron, Wei Shao, Blair R. Leavitt, Michael R. Hayden, Donald W. Nicholson, and Maya Saleh
http://www.pnas.org/cgi/content/abstract/106/22/9016?etoc

Enhanced cytoprotective effects of the IAP protein, c-IAP1, through stabilization with TRAF2
Rebecca A. Csomos, Graham F. Brady, and Colin S. Duckett
http://www.jbc.org/cgi/content/abstract/M109.029983v1

Critical Role for Caspase-8 in Epidermal Growth Factor Signaling
Darren Finlay, Amy Howes, and Kristiina Vuori
http://cancerres.aacrjournals.org/cgi/content/abstract/69/12/5023

Caspase-10-Mediated Heat Shock Protein 90β Cleavage Promotes UVB Irradiation-Induced Cell Apoptosis
Hehua Chen, Yan Xia, Dexing Fang, David Hawke, and Zhimin Lu
http://mcb.asm.org/cgi/content/abstract/29/13/3657

Ordering of caspases in cells undergoing apoptosis by the intrinsic pathway
S Inoue, G Browne, G Melino & G M Cohen
http://www.nature.com/cdd/journal/v16/n7/full/cdd200929a.html

Single-cell imaging of retinal ganglion cell apoptosis with a cell-penetrating, activatable peptide probe in an in vivo glaucoma model
Edward M. Barnett, Xu Zhang, Dustin Maxwell, Qing Chang, and David Piwnica-Worms
http://www.pnas.org/content/106/23/9391.abstract?etoc

The antiapoptotic protein AAC-11 interacts with and regulates Acinus-mediated DNA fragmentation
Patricia Rigou, Valeria Piddubnyak, Audrey Faye, Jean-Christophe Rain, Laurence Michel, Fabien Calvo and Jean-Luc Poyet
http://www.nature.com/emboj/journal/v28/n11/abs/emboj2009106a.html

REVIEWS / COMMENTS

A few reviews on autophagy in CDD: http://www.nature.com/cdd/journal/v16/n7/index.html

Caspase activation pathways: some recent progress
S P Cullen & S J Martin
http://www.nature.com/cdd/journal/v16/n7/full/cdd200959a.html

Dynamics of mitochondrial structure during apoptosis and the enigma of Opa1
Ryuji Yamaguchi, Guy Perkins
http://dx.doi.org/10.1016/j.bbabio.2009.02.005

cIAP Proteins: Keystones in NOD Receptor Signal Transduction
C. Reardon and T.W. Mak
http://www.cell.com/immunity/abstract/S1074-7613%2809%2900243-X

Targeting Bcl-2 based on the interaction of its BH4 domain with the inositol 1,4,5-trisphosphate receptor
Yi-Ping Rong, Paul Barr, Vivien C. Yee, Clark W. Distelhorst http://www.sciencedirect.com/science/journal/01674889

Letting go: modification of cell adhesion during apoptosis
Suzanne M, Steller H
http://jbiol.com/content/8/5/49

When separation means death: killing through the mitochondria, but starting from the endoplasmic reticulum
Violeta Lamarca and Luca Scorrano
http://www.nature.com/emboj/journal/v28/n12/full/emboj2009135a.html

Apoptosis: Death by ubiquitylation
http://www.nature.com/nrm/journal/v10/n7/full/nrm2714.html

Apoptosis and cancer: the genesis of a research field
Thomas G. Cotter
http://www.nature.com/nrc/journal/v9/n7/full/nrc2663.html

Supplemental Siberia I – into the cold
Mole
http://jcs.biologists.org/cgi/content/full/122/12/1931
Supplemental material: http://jcs.biologists.org/cgi/content/full/122/12/1931/DC1

Apolist – may 2009

Death receptors

Cullin3-Based Polyubiquitination and p62-Dependent Aggregation of Caspase-8 Mediate Extrinsic Apoptosis Signaling
Z. Jin, Y. Li, R. Pitti, D. Lawrence, V.C. Pham, J.R. Lill, and A. Ashkenazi
http://dx.doi.org/10.1016/j.cell.2009.03.015

Mechanism of procaspase-8 activation by c-FLIPL
Jong W. Yu, Philip D. Jeffrey, and Yigong Shi
http://www.pnas.org/content/106/20/8169.full

Fas-Mediated Apoptosis Is Regulated by the Extracellular Matrix Protein CCN1 (CYR61) In Vitro and In Vivo
Vladislava Juric, Chih-Chiun Chen, and Lester F. Lau
http://mcb.asm.org/cgi/content/abstract/29/12/3266

DISC-mediated activation of caspase-2 in DNA damage-induced apoptosis
M Olsson, H Vakifahmetoglu, P M Abruzzo, K Högstrand, A Grandien & B Zhivotovsky
http://www.nature.com/onc/journal/v28/n18/full/onc200936a.html

Akt and 14-3-3 Control a PACS-2 Homeostatic Switch that Integrates Membrane Traffic with TRAIL-Induced Apoptosis
J.E. Aslan, H. You, D.M. Williamson, J. Endig, R.T. Youker, L. Thomas, H. Shu, Y. Du, R.L. Milewski, M.H. Brush, A. Possemato, K. Sprott, H. Fu, K.D. Greis, D.N. Runckel, A. Vogel, and G. Thomas
http://www.cell.com/molecular-cell/abstract/S1097-2765(09)00240-8

Modulation of Caspase Activity Regulates Skeletal Muscle Regeneration and Function in Response to Vasopressin and Tumor Necrosis Factor
Viviana Moresi, Gisela Garcia-Alvarez, Alessandro Pristerà, Emanuele Rizzuto, Maria C. Albertini, Marco Rocchi, Giovanna Marazzi, David Sassoon, Sergio Adamo, Dario Coletti
http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0005570



BH3

Bcl-2 Proteins EGL-1 and CED-9 Do Not Regulate Mitochondrial Fission or Fusion in Caenorhabditis elegans
D.G. Breckenridge, B.-H. Kang, and D. Xue
http://www.cell.com/current-biology/abstract/S0960-9822%2809%2900825-2

BH3 Peptides Induce Mitochondrial Fission and Cell Death Independent of BAX/BAK
Emelyn H. Shroff, Colleen M. Snyder, G. R. Scott Budinger, Manu Jain, Teng-Leong Chew, Satya Khuon, Harris Perlman, Navdeep S. Chandel
http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0005646

Execution of Superoxide-Induced Cell Death by the Proapoptotic Bcl-2-Related Proteins Bid and Bak
Muniswamy Madesh, Wei-Xing Zong, Brian J. Hawkins, Subbiah Ramasamy, Thilagavathi Venkatachalam, Partha Mukhopadhyay, Patrick J. Doonan, Krishna M. Irrinki, Mohanraj Rajesh, Pál Pacher, and Craig B. Thompson
http://mcb.asm.org/cgi/content/abstract/29/11/3099

Bcl-2 complexed with Beclin-1 maintains full anti-apoptotic function
I A Ciechomska, G C Goemans, J N Skepper and A M Tolkovsky
http://www.nature.com/onc/journal/v28/n21/full/onc200960a.html

KRAB-type zinc-finger protein Apak specifically regulates p53-dependent apoptosis
Chunyan Tian, Guichun Xing, Ping Xie, Kefeng Lu, Jing Nie, Jian Wang, Li Li, Mei Gao, Lingqiang Zhang and Fuchu He
http://www.nature.com/ncb/journal/v11/n5/full/ncb1864.html



Other

The Patched dependence receptor triggers apoptosis through a DRAL-caspase-9 complex
Frédéric Mille, Chantal Thibert, Joanna Fombonne, Nicolas Rama, Catherine Guix, Hideki Hayashi, Véronique Corset, John C. Reed and Patrick Mehlen
http://www.nature.com/ncb/journal/v11/n6/full/ncb1880.html

DeadEasy Caspase: Automatic Counting of Apoptotic Cells in Drosophila
Manuel G. Forero, Jenny A. Pennack, Anabel R. Learte, Alicia Hidalgo
http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0005441

Apoptosis is not required for mammalian neural tube closure
Valentina Massa, Dawn Savery, Patricia Ybot-Gonzalez, Elisabetta Ferraro, Anthony Rongvaux, Francesco Cecconi, Richard Flavell, Nicholas D. E. Greene, and Andrew J. Copp
http://www.pnas.org/content/106/20/8233.abstract?etoc

The VDAC1 N-terminus is essential both for apoptosis and the protective effect of anti-apoptotic proteins
Salah Abu-Hamad, Nir Arbel, Doron Calo, Laetitia Arzoine, Adrian Israelson, Nurit Keinan, Ronit Ben-Romano, Orr Friedman, and Varda Shoshan-Barmatz
http://jcs.biologists.org/cgi/content/abstract/122/11/1906

Stress-dependent chip/DAXX interaction suppresses the p53 apoptotic program
Holly McDonough, Peter C. Charles, Eleanor G. Hilliard, Shu-Bing Qian, Jin-na Min, Andrea L. Portbury, Douglas M. Cyr, and Cam Patterson
http://www.jbc.org/cgi/content/abstract/M109.011767v1



REVIEWS / COMMENTS

Cytoplasmic functions of the tumour suppressor p53
Douglas R. Green and Guido Kroemer
http://www.nature.com/nature/journal/v458/n7242/full/4581118a.html

The CULt of Caspase-8 Ubiquitination
M. Békés and G.S. Salvesen
http://dx.doi.org/10.1016/j.cell.2009.04.052

Of Elections and Cell-Death Decisions
P. Loriaux and A. Hoffmann
http://dx.doi.org/10.1016/j.molcel.2009.05.001

Immunogenic and tolerogenic cell death
Douglas R. Green, Thomas Ferguson, Laurence Zitvogel & Guido Kroemer
http://www.nature.com/nri/journal/v9/n5/abs/nri2545.html

Beclin 1: a BH3-only protein that fails to induce apoptosis
P Boya and G Kroemer
http://www.nature.com/onc/journal/v28/n21/full/onc200983a.html

Human caspases: Activation, specificity and regulation
Cristina Pop and Guy S Salvesen
http://www.jbc.org/cgi/content/abstract/R800084200v1

Hyung Don Ryoo: A healthy career in cellular death
Ruth Williams
http://jcb.rupress.org/cgi/content/full/185/5/758?etoc

Apolist – april 2009

APOLIST – APRIL 2009

Caspases

Caspase-2 activation in the absence of PIDDosome formation
Claudia Manzl, Gerhard Krumschnabel, Florian Bock, Benedicte Sohm,
Verena Labi, Florian Baumgartner, Emmanuelle Logette, Jürg Tschopp,
and Andreas Villunger
http://jcb.rupress.org/cgi/content/abstract/185/2/291?etoc

Caspase-8 Association with the Focal Adhesion Complex Promotes Tumor
Cell Migration and Metastasis
Simone Barbero, Ainhoa Mielgo, Vicente Torres, Tal Teitz, David J.
Shields, David Mikolon, Matthew Bogyo, Daniela Barilà, Jill M. Lahti,
David Schlaepfer, and Dwayne G. Stupack
http://cancerres.aacrjournals.org/cgi/content/abstract/69/9/3755

Bicaudal Is a Conserved Substrate for Drosophila and Mammalian
Caspases and Is Essential for Cell Survival
Emma M. Creagh, Gabriela Brumatti, Clare Sheridan, Patrick J. Duriez,
Rebecca C. Taylor, Sean P. Cullen, Colin Adrain, Seamus J. Martin
http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0005055

BH3

Mitochondrial Outer Membrane Proteins Assist Bid in Bax-mediated
Lipidic Pore Formation
Blanca Schafer, Joel Quispe, Vineet Choudhary, Jerry E. Chipuk, Teddy
G. Ajero, Han Du, Roger Schneiter, and Tomomi Kuwana
http://www.molbiolcell.org/cgi/content/abstract/20/8/2276?etoc

Bax activation by the BH3-only protein Puma promotes cell dependence
on antiapoptotic Bcl-2 family members
Tristan Gallenne, Fabien Gautier, Lisa Oliver, Eric Hervouet, Belinda
Noël, John A. Hickman, Olivier Geneste, Pierre-François Cartron,
François M. Vallette, Stephen Manon, and Philippe Juin
http://jcb.rupress.org/cgi/content/abstract/185/2/279?etoc

TOM-independent complex formation of Bax and Bak in mammalian
mitochondria during TNF-induced apoptosis
K Ross, T Rudel & V Kozjak-Pavlovic
http://www.nature.com/cdd/journal/v16/n5/full/cdd2008194a.html

Puma and to a lesser extent Noxa are suppressors of Myc-induced lymphomagenesis
E M Michalak, E S Jansen, L Happo, M S Cragg, L Tai, G K Smyth, A
Strasser, J M Adams & C L Scott
http://www.nature.com/cdd/journal/v16/n5/full/cdd2008195a.html

The Epstein–Barr virus Bcl-2 homolog, BHRF1, blocks apoptosis by
binding to a limited amount of Bim
Anthony L. Desbien, John W. Kappler, and Philippa Marrack
http://www.pnas.org/content/106/14/5663.abstract?etoc

The von Hippel-Lindau protein sensitizes renal carcinoma cells to
apoptotic stimuli through stabilization of BIMEL
Y Guo, M C Schoell & R S Freeman
http://www.nature.com/onc/journal/v28/n16/abs/onc200935a.html

Nucleophosmin blocks mitochondrial localization of p53 and apoptosis
Sanjit Kumar Dhar and Daret K. St. Clair
http://www.jbc.org/cgi/content/abstract/M109.005736v1

A novel Bcl-XL inhibitor Z36 that induces autophagic cell death in Hela cells
Jian Lin, Zhibin Zheng, Yanjun Li, Wenyu Yu, Wu Zhong, Songhai Tian,
Fang Zhao, Xiaobai Ren, Junhai Xiao, Nan Wang, Siyang Liu, Lili Wang,
Fugeng Sheng, Yingyu Chen, Changwen Jin, Song Li and Bin Xia
http://www.landesbioscience.com/journals/autophagy/article/7888

Hypoxia-Induced Autophagy Is Mediated through Hypoxia-Inducible Factor
Induction of BNIP3 and BNIP3L via Their BH3 Domains
Grégory Bellot, Raquel Garcia-Medina, Pierre Gounon, Johanna Chiche,
Danièle Roux, Jacques Pouysségur, and Nathalie M. Mazure
http://mcb.asm.org/cgi/content/abstract/29/10/2570

Death receptors

Non-genetic origins of cell-to-cell variability in TRAIL-induced apoptosis
Sabrina L. Spencer, Suzanne Gaudet, John G. Albeck, John M. Burke &
Peter K. Sorger
http://www.nature.com/nature/journal/vaop/ncurrent/full/nature08012.html

Notch1 signaling sensitizes TRAIL-induced apoptosis in human
hepatocellular carcinoma cells by inhibiting Akt/Hdm2-mediated p53
degradation and up-regulating p53-dependent DR5 expression
Chunmei Wang, Runzi Qi, Nan Li, Zhengxin Wang, Huazhang An, Qinghua
Zhang, Yizhi Yu, and Xuetao Cao
http://www.jbc.org/cgi/content/abstract/M109.002105v1

IAPs

Regulation of XIAP Translation and Induction by MDM2 following Irradiation
L. Gu, N. Zhu, H. Zhang, D.L. Durden, Y. Feng, and M. Zhou
http://www.cell.com/cancer-cell/abstract/S1535-6108%2809%2900077-4

Skeletal Muscle Differentiation Evokes Endogenous XIAP to Restrict the
Apoptotic Pathway
Michelle I. Smith et al.
http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0005097

Other

Ablation of Key Oncogenic Pathways by RITA-Reactivated p53 Is Required
for Efficient Apoptosis
V.V. Grinkevich, F. Nikulenkov, Y. Shi, M. Enge, W. Bao, A. Maljukova,
A. Gluch, A. Kel, O. Sangfelt, and G. Selivanova
http://www.cell.com/cancer-cell/abstract/S1535-6108%2809%2900110-X

Tyrosine dephosphorylation of H2AX modulates apoptosis and survival decisions
Peter J. Cook1,2,5, Bong Gun Ju1,3,5, Francesca Telese1, Xiangting
Wang1, Christopher K. Glass4 & Michael G. Rosenfeld
http://www.nature.com/nature/journal/v458/n7238/full/nature07849.html

Antimicrobial peptide-induced apoptotic death of Leishmania results
from calcium-dependent, caspase-independent mitochondrial toxicity
Manjusha M. Kulkarni, W. Robert McMaster, Wojciech Kamysz, and
Bradford S. McGwire
http://www.jbc.org/cgi/content/abstract/M809079200v1

The Early Apoptotic DNA Fragmentation Targets a Small Number of
Specific Open Chromatin Regions
Miriam Di Filippo, Giorgio Bernardi
http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0005010

Tim-3 mediates phagocytosis of apoptotic cells and cross-presentation
Masafumi Nakayama, Hisaya Akiba, Kazuyoshi Takeda, Yuko Kojima,
Masaaki Hashiguchi, Miyuki Azuma, Hideo Yagita, and Ko Okumura
http://bloodjournal.hematologylibrary.org/cgi/content/abstract/113/16/3821

REVIEWS / COMMENTS

April Fish
D R Green
Editor-in-Chief, Oncogene
http://www.nature.com/onc/journal/v28/n13/full/onc200928a.html

EMBO workshop on cytotoxicity, cell death and the immune system
A Anel, C Bleackley, C Borner, P Golstein, P H Krammer, A Müllbacher,
J Pardo, M M Simon & J A Trapani
http://www.nature.com/cdd/journal/v16/n5/full/cdd20094a.html

Is TRAIL the holy grail of cancer therapy?
Thomas Newsom-Davis, Silvia Prieske, Henning Walczak
http://www.springerlink.com/content/m4331mug22202113/fulltext.html

Bcl2 family proteins in carcinogenesis and the treatment of cancer
Anna Frenzel, Francesca Grespi, Waldemar Chmelewskij, Andreas Villunger
http://www.springerlink.com/content/e80363n402846317/fulltext.html

Inflammasomes in infection and inflammation
Christian R. McIntire, Garabet Yeretssian, Maya Saleh
http://www.springerlink.com/content/68t4252214270158/

Puma strikes Bax
Anthony Letai
http://jcb.rupress.org/cgi/content/abstract/185/2/189?etoc

Unleashing the power of inhibitors of oncogenic kinases through BH3 mimetics
Mark S. Cragg, Claire Harris, Andreas Strasser & Clare L. Scott
http://www.nature.com/nrc/journal/v9/n5/full/nrc2615.html

Tumour necrosis factor and cancer
Frances Balkwill
http://www.nature.com/nrc/journal/v9/n5/full/nrc2628.html

Compilated by Cristina Muñoz-Pinedo