Caspases and IAPs
Caspase-2 regulates S-phase cell cycle events to protect from DNA damage accumulation independent of apoptosis – Ashley G. Boice, Karla E. Lopez, Raj K. Pandita, Melissa J. Parsons, Chloe I. Charendoff, Vijay Charaka, Alexandre F. Carisey, Tej K. Pandita and Lisa Bouchier-Hayes. https://www.nature.com/articles/s41388-021-02085-w
XIAP restrains TNF-driven intestinal inflammation and dysbiosis by promoting innate immune responses of Paneth and dendritic cells – Adam Wahida, Madeleine Müller, Andreas Hiergeist, Bastian Popper, Katja Steiger, Caterina Branca, Markus Tschurtschenthaler, Thomas Engleitner, Sainitin Donakonda, Jordy De Coninck, Rupert Öllinger, Marie K. Pfautsch, Nicole Müller, Miguel Silva, Sinem Usluer, Erik Thiele Oberg, Jan P. Böttcher, Nicole Pfarr, Martina Anton, Julia B. Slotta-Huspenina, Andreas G. Nerlich, Tobias Madl, Marijana Basic, André Bleich, Geert Berx, Jürgen Ruland, Percy A. Knolle, Roland Rad, Timon E. Adolph, Peter Vandenabeele, Hirokazu Kanegane, André Gessner, Philipp J. Jost, Monica Yabal. https://www.science.org/doi/full/10.1126/sciimmunol.abf7235
Deficiency in X-linked inhibitor of apoptosis protein promotes susceptibility to microbial triggers of intestinal inflammation – Anne Strigli, Shreya Gopalakrishnan, Yvonne Zeissig, Marijana Basic, Jun Wang, Tobias Schwerd, Shauni Doms, Kenneth Peuker, Jelka Hartwig, Jürgen Harder, Pia Hönscheid, Philipp Arnold, Thomas Kurth, Fabian Rost, Britt-Sabina Petersen, Michael Forster, Andre Franke, Judith R. Kelsen, Meino Rohlfs, Christoph Klein, Aleixo M. Muise, Neil Warner, Ryusuke Nambu, Julia Mayerle, Helga-Paula Török, Andreas Linkermann, Michael H. Muders, Gustavo B. Baretton, Jochen Hampe, Daniela E. Aust, John F. Baines, André Bleich, Sebastian Zeissig. https://www.science.org/doi/full/10.1126/sciimmunol.abf7473
SMAC/Diablo controls proliferation of cancer cells by regulating phosphatidylethanolamine synthesis – Swaroop Kumar Pandey, Avijit Paul, Anna Shteinfer-Kuzmine, Ran Zalk, Uwe Bunz, Varda Shoshan-Barmatz. https://febs.onlinelibrary.wiley.com/doi/full/10.1002/1878-0261.12959
Efferocytosis, entosis, cell-cell
Apoptotic stress-induced FGF signalling promotes non-cell autonomous resistance to cell death – Florian J. Bock, Egor Sedov, Elle Koren, Anna L. Koessinger, Catherine Cloix, Désirée Zerbst, Dimitris Athineos, Jayanthi Anand, Kirsteen J. Campbell, Karen Blyth, Yaron Fuchs and Stephen W. G. Tait. https://www.nature.com/articles/s41467-021-26613-0
TRAIL signaling promotes entosis in colorectal cancer – Emir Bozkurt; Heiko Düssmann; Manuela Salvucci; Brenton L. Cavanagh ; Sandra Van Schaeybroeck; Daniel B. Longley; Seamus J. Martin; Jochen H.M. Prehn. https://rupress.org/jcb/article-abstract/220/11/e202010030/212649
Human intestinal and circulating invariant natural killer T cells are cytotoxic against colorectal cancer cells via the perforin–granzyme pathway – Angélica Díaz-Basabe, Claudia Burrello, Georgia Lattanzi, Fiorenzo Botti, Alberto Carrara, Elisa Cassinotti, Flavio Caprioli, Federica Facciotti. https://febs.onlinelibrary.wiley.com/doi/full/10.1002/1878-0261.13104
Death receptors
HOIP limits anti‐tumor immunity by protecting against combined TNF and IFN‐gamma‐induced apoptosis – Andrew J Freeman, Stephin J Vervoort, Jessica Michie, Kelly M Ramsbottom, John Silke, Conor J Kearney, Jane Oliaro. https://www.embopress.org/doi/abs/10.15252/embr.202153391
A patch of positively charged residues regulates the efficacy of clinical DR5 antibodies in solid tumors – Gururaj Shivange, Tanmoy Mondal, Evan Lyerly, Sanchita Bhatnagar, Charles N. Landen, Shivani Reddy, Jonathan Kim, Britney Doan, Paula Riddle, Jogender Tushir-Singh. https://www.cell.com/cell-reports/fulltext/S2211-1247(21)01430-3
A comprehensive interaction study provides a potential domain interaction network of human death domain superfamily proteins – Wei Zhou, Naoe Kaneko, Tomoya Nakagita, Hiroyuki Takeda and Junya Masumoto. https://www.nature.com/articles/s41418-021-00796-x
TRAIL/DR5 pathway promotes AKT phosphorylation, skeletal muscle differentiation, and glucose uptake – Barbara Toffoli, Federica Tonon, Veronica Tisato, Giorgio Zauli, Paola Secchiero, Bruno Fabris and Stella Bernardi. https://www.nature.com/articles/s41419-021-04383-3
Necroptosis, RIP kinases, MLKL
Oligomerization‐driven MLKL ubiquitylation antagonizes necroptosis – Zikou Liu, Laura F Dagley, Kristy Shield-Artin, Samuel N Young, Aleksandra Bankovacki, Xiangyi Wang, Michelle Tang, Jason Howitt, Che A Stafford, Ueli Nachbur, Cheree Fitzgibbon, Sarah E Garnish, Andrew I Webb, David Komander, James M Murphy, Joanne M Hildebrand, John Silke. https://www.embopress.org/doi/abs/10.15252/embj.2019103718
Human RIPK3 maintains MLKL in an inactive conformation prior to cell death by necroptosis – Yanxiang Meng, Katherine A. Davies and James M. Murphy. https://www.nature.com/articles/s41467-021-27032-x
MLKL promotes cellular differentiation in myeloid leukemia by facilitating the release of G-CSF – Xin Wang, Uris Ros, Deepti Agrawal, Eva C. Keller, Julia Slotta-Huspenina, Veronika Dill, Bo Shen, Run Shi, Tobias Herold, Claus Belka, Ritu Mishra, Florian Bassermann, Ana J. Garcia-Saez and Philipp J. Jost. https://www.nature.com/articles/s41418-021-00811-1
Caspase‐9 acts as a regulator of necroptotic cell death – Tamás Molnár, Petra Pallagi, Bálint Tél, Róbert Király, Eszter Csoma, Viktória Jenei, Zsófia Varga, Péter Gogolák, Anne Odile Hueber, Zoltán Máté, Ferenc Erdélyi, Gábor Szabó, Aladár Pettkó-Szandtner, Attila Bácsi, László Virág, József Maléth, Gábor Koncz. https://febs.onlinelibrary.wiley.com/doi/full/10.1111/febs.15898
Quantitative analysis of phosphoproteome in necroptosis reveals a role of TRIM28 phosphorylation in promoting necroptosis-induced cytokine production – Rui Zu, Zhen Yu, Jing Zhao, Xiaojuan Lu, Wei Liang, Le Sun, Chenfang Si, Kezhou Zhu, Tian Zhang, Ganquan Li, Mengmeng Zhang, Yaoyang Zhang, Nan Liu, Junying Yuan and Bing Shan. https://www.nature.com/articles/s41419-021-04290-7
Genetic inhibition of RIPK3 ameliorates functional outcome in controlled cortical impact independent of necroptosis – Limin Wu, Joon Yong Chung, Tian Cao, Gina Jin, William J. Edmiston III, Suzanne Hickman, Emily S. Levy, Jordyn A. Whalen, Eliza Sophie LaRovere Abrams, Alexei Degterev, Eng H. Lo, Lorenzo Tozzi, David L. Kaplan, Joseph El Khoury and Michael J. Whalen. https://www.nature.com/articles/s41419-021-04333-z
Proteomic analysis of necroptotic extracellular vesicles – Inbar Shlomovitz, Ziv Erlich, Gali Arad, Liat Edry-Botzer, Sefi Zargarian, Hadar Cohen, Tal Manko, Yifat Ofir-Birin, Tomer Cooks, Neta Regev-Rudzki and Motti Gerlic. https://www.nature.com/articles/s41419-021-04317-z
Reviews
Molecular mechanisms and functions of pyroptosis in inflammation and antitumor immunity – Junwei Hou, Jung-Mao Hsu, Mien-Chie Hung. https://www.cell.com/molecular-cell/fulltext/S1097-2765(21)00737-1
Soluble CD95L in cancers and chronic inflammatory disorders, a new therapeutic target? – Keerthi Kurma, Andrea Boizard-Moracchini, Gael Galli, Mickael Jean, Pierre Vacher, Patrick Blanco, Patrick Legembre. https://www.sciencedirect.com/science/article/abs/pii/S0304419X21000937
First we eat, then we do everything else: The dynamic metabolic regulation of efferocytosis – Alissa Trzeciak, Ya-Ting Wang, Justin Shaun Arnold Perry. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(21)00364-8
Apoptotic cell-derived metabolites in efferocytosis-mediated resolution of inflammation – Yiwei Mao. https://www.sciencedirect.com/science/article/abs/pii/S1359610121000745
Dying cells fan the flames of inflammation – Kim Newton, Vishva M. Dixit, Nobuhiko Kayagaki. https://www.science.org/doi/10.1126/science.abi5934#.YaAPliOd4NI
Comments
Cell death leaves a new TRAIL – Michael Overholtzer. https://rupress.org/jcb/article/220/11/e202109018/212699
In Conversation with Tony Letai – Eleni Skourti, Anthony Letai. https://febs.onlinelibrary.wiley.com/doi/full/10.1111/febs.16229
Editor Profile: Eli Arama. https://febs.onlinelibrary.wiley.com/doi/full/10.1111/febs.15902
Bcl-xL and IP3R interaction: Intimate relationship with an uncertain outcome – Nikolay Popgeorgieva, Germain Gillet. https://www.sciencedirect.com/science/article/abs/pii/S0143416021001585
Bcl-2 family proteins
Bcl-xL acts as an inhibitor of IP3R channels, thereby antagonizing Ca2+-driven apoptosis – Nicolas Rosa, Hristina Ivanova, Larry E. Wagner 2nd, Justin Kale, Rita La Rovere, Kirsten Welkenhuyzen, Nikolaos Louros, Spyridoula Karamanou, Victoria Shabardina, Irma Lemmens, Elien Vandermarliere, Kozo Hamada, Hideaki Ando, Frederic Rousseau, Joost Schymkowitz, Jan Tavernier, Katsuhiko Mikoshiba, Anastassios Economou, David W. Andrews, Jan B. Parys, David I. Yule and Geert Bultynck. https://www.nature.com/articles/s41418-021-00894-w
BH3-only proteins Puma and Beclin1 regulate autophagic death in neurons in response to Amyloid-β – Akash Saha, Suraiya Saleem, Paidi Ramesh Kumar and Subhas C. Biswas. https://www.nature.com/articles/s41420-021-00748-x
The BAX-binding protein MOAP1 associates with LC3 and promotes closure of the phagophore – Hao-Chun Chang, Ran N. Tao, Chong Teik Tan, Ya Jun Wu, Boon Huat Bay and Victor C. Yu. https://www.tandfonline.com/doi/full/10.1080/15548627.2021.1896157
Venetoclax imparts distinct cell death sensitivity and adaptivity patterns in T cells – Lindsey M. Ludwig, Katrina M. Hawley, David B. Banks, Anika T. Thomas-Toth, Bruce R. Blazar, Megan E. McNerney, Joel D. Leverson and James L. LaBelle. https://www.nature.com/articles/s41419-021-04285-4
Development of a BCL-xL and BCL-2 dual degrader with improved anti-leukemic activity – Dongwen Lv, Pratik Pal, Xingui Liu, Yannan Jia, Dinesh Thummuri, Peiyi Zhang, Wanyi Hu, Jing Pei, Qi Zhang, Shuo Zhou, Sajid Khan, Xuan Zhang, Nan Hua, Qingping Yang, Sebastian Arango, Weizhou Zhang, Digant Nayak, Shaun K. Olsen, Susan T. Weintraub, Robert Hromas, Marina Konopleva, Yaxia Yuan, Guangrong Zheng and Daohong Zhou. https://www.nature.com/articles/s41467-021-27210-x
Paradoxical implication of BAX/BAK in the persistence of tetraploid cells – Jiayin Deng, Lucía G. Gutiérrez, Gautier Stoll, Omar Motiño, Isabelle Martins, Lucía Núñez, José Manuel Bravo-San Pedro, Juliette Humeau, Chloé Bordenave, Juncheng Pan, Hélène Fohrer-Ting, Sylvie Souquere, Gerard Pierron, Claudio Hetz, Carlos Villalobos, Guido Kroemer and Laura Senovilla. https://www.nature.com/articles/s41419-021-04321-3
UBQLN4 is an ATM substrate that stabilizes the anti‐apoptotic proteins BCL2A1 and BCL2L10 in mesothelioma – Fang Liu, RunSang Pan, HongYu Ding, LiLing Gu, Yun Yang, ChuanYin Li, YongJie Xu, Ronggui Hu, Hui Chen, XiangYan Zhang, YingJie Nie. https://febs.onlinelibrary.wiley.com/doi/full/10.1002/1878-0261.13058
BAX mitochondrial integration is regulated allosterically by its α1−α2 loop – Michael A. Dengler, Leonie Gibson and Jerry M. Adams. https://www.nature.com/articles/s41418-021-00815-x
Pyroptosis
Gasdermin D mediates host cell death bu not interleukin-1β secretion in Mycobacterium tuberculosis-infected macrophages – Sebastian J. Theobald, Jessica Gräb, Melanie Fritsch, Isabelle Suárez, Hannah S. Eisfeld, Sandra Winter, Maximilian Koch, Christoph Hölscher, Manolis Pasparakis, Hamid Kashkar and Jan Rybniker. https://www.nature.com/articles/s41420-021-00716-5
Apoptosis and cell death 