ApoList – January 2018

Bcl-2 family proteins

Measurement of BH3-only protein tolerance
Haiming Dai, Husheng Ding, Kevin L Peterson, X Wei Meng, Paula A Schneider, Katherine L B Knorr & Scott H Kaufmann

E2F1 interacts with BCL‐xL and regulates its subcellular localization dynamics to trigger cell death
Céline Vuillier, Steven Lohard, Aurélie Fétiveau, Jennifer Allègre, Cémile Kayaci, Louise E King, Frédérique Braun, Sophie Barillé‐Nion, Fabien Gautier, Laurence Dubrez, Andrew P Gilmore, Philippe P Juin and Laurent Maillet

Systems modeling accurately predicts responses to genotoxic agents and their synergism with BCL-2 inhibitors in triple negative breast cancer cells.
Lucantoni F, Lindner AU, O’Donovan N, Düssmann H, Prehn JHM.

Deubiquitinase USP13 dictates MCL1 stability and sensitivity to BH3 mimetic inhibitors
Shengzhe Zhang, Meiying Zhang, Ying Jing, Xia Yin, Pengfei Ma, Zhenfeng Zhang, Xiaojie Wang, Wen Di & Guanglei Zhuang

Crystal Structures of Anti-apoptotic BFL-1 and Its Complex with a Covalent Stapled Peptide Inhibitor
Edward P. Harvey, Hyuk-Soo Seo, Rachel M. Guerra, Gregory H. Bird, Sirano Dhe-Paganon, Loren D. Walensky

The BET bromodomain inhibitor CPI203 overcomes resistance to ABT-199 (venetoclax) by downregulation of BFL-1/A1 in in vitro and in vivo models of MYC+/BCL2+ double hit lymphoma
A. Esteve-Arenys, J. G. Valero, A. Chamorro-Jorganes, D. Gonzalez, V. Rodriguez, I. Dlouhy, I. Salaverria, E. Campo, D. Colomer, A. Martinez, G. Rymkiewicz, P. Pérez-Galán, A. Lopez-Guillermo & G. Roué

Therapeutic synergy between tigecycline and venetoclax in a preclinical model of MYC/BCL2 double-hit B cell lymphoma
Micol Ravà, Aleco D’Andrea, Paola Nicoli, Ilaria Gritti, Giulio Donati, Mirko Doni, Marco Giorgio, Daniela Olivero and Bruno Amati

A double point mutation at residues Ile14 and Val15 of Bcl-2 uncovers a role for the BH4 domain in both protein stability and function
Giovanni Monaco, Rita La Rovere, Spyridoula Karamanou, Kirsten Welkenhuyzen, Hristina Ivanova, Elien Vandermarliere, Marta Di Martile, Donatella Del Bufalo, Humbert De Smedt, Jan B. Parys, Anastassios Economou and Geert Bultynck

Iterative optimization yields Mcl-1–targeting stapled peptides with selective cytotoxicity to Mcl-1–dependent cancer cells
Raheleh Rezaei Araghi, Gregory H. Bird, Jeremy A. Ryan, Justin M. Jenson, Marina Godes, Jonathan R. Pritz, Robert A. Grant, Anthony Letai, Loren D. Walensky, and Amy E. Keating

Targeting Mcl-1 enhances DNA replication stress sensitivity to cancer therapy
Guo Chen, Andrew T. Magis, Ke Xu, Dongkyoo Park, David S. Yu, Taofeek K. Owonikoko, Gabriel L. Sica, Sarah W. Satola, Suresh S. Ramalingam, Walter J. Curran, Paul W. Doetsch, and Xingming Deng

Caspase cleavage of Mcl-1 impairs its anti-apoptotic activity and proteasomal degradation in non-small lung cancer cells
Ting Wang, Zhiwei Yang, Yimeng Zhang, Xiang Zhang, Lei Wang, Shengli Zhang & Lintao Jia

Proapoptotic PUMA targets stem-like breast cancer cells to suppress metastasis
Qi Sun, Jacqueline Lesperance, Hiromi Wettersten, Elaine Luterstein, Yoko S. DeRose, Alana Welm, David A. Cheresh, and Jay S. Desgrosellier

Coordinated repression of BIM and PUMA by Epstein–Barr virus latent genes maintains the survival of Burkitt lymphoma cells
Leah Fitzsimmons, Andrew J Boyce, Wenbin Wei, Catherine Chang, Deborah Croom-Carter et al.

Predicting effective pro-apoptotic anti-leukaemic drug combinations using co-operative dynamic BH3 profiling
Martin Grundy, Claire Seedhouse, Thomas Jones, Liban Elmi, Michael Hall, Adam Graham, Nigel Russell, Monica Pallis

Molecular docking studies of bioactive compounds from Annona muricataLinn as potential inhibitors for Bcl-2, Bcl-w and Mcl-1 antiapoptotic proteins
Mohamad Norisham Mohamad Rosdi, Shahkila Mohd Arif, Mohamad Hafizi Abu Bakar, Siti Aisyah Razali, Razauden Mohamed Zulkifli & Harisun Ya’akob

Sensitisation to mitoxantrone-induced apoptosis by the oncolytic adenovirus Ad∆∆ through Bcl-2-dependent attenuation of autophagy
Carmen Aguirre-Hernández, Héctor Maya-Pineda, Julia San Millán, Y. K. Stella Man, Yong-Jie Lu & Gunnel Halldén

Mitochondrial levels determine variability in cell death by modulating apoptotic gene expression
Silvia Márquez-Jurado, Juan Díaz-Colunga, Ricardo Pires das Neves, Antonio Martinez-Lorente, Fernando Almazán, Raúl Guantes & Francisco J. Iborra

BAD and KATP channels regulate neuron excitability and epileptiform activity
Juan Ramón Martínez-François, María Carmen Fernández-Agüera, Nidhi Nathwani, Carolina Lahmann, Veronica L Burnham, Nika N Danial, Gary Yellen

Caspases, IAPs

Involvement of both caspase-8 and Noxa-activated pathways in endoplasmic reticulum stress-induced apoptosis in triple-negative breast tumor cells
Ana Cano-González, Marta Mauro-Lizcano, Daniel Iglesias-Serret, Joan Gil & Abelardo López-Rivas

Caspase-10: a molecular switch from cell-autonomous apoptosis to communal cell death in response to chemotherapeutic drug treatment
Andrea Mohr, Laura Deedigan, Sylwia Jencz, Yasamin Mehrabadi, Lily Houlden, Stella-Maris Albarenque & Ralf M Zwacka

Caspase-4 activation by a bacterial surface protein is mediated by cathepsin G in human gingival fibroblasts
Hye-Kyoung Jun, Young-Jung Jung, Suk Ji, Sun-Jin An & Bong-Kyu Choi

IL-6 receptor blockade corrects defects of XIAP-deficient regulatory T cells
Wan-Chen Hsieh, Tzu-Sheng Hsu, Ya-Jen Chang & Ming-Zong Lai

Death receptors

Mitochondrial levels determine variability in cell death by modulating apoptotic gene expression
Silvia Márquez-Jurado, Juan Díaz-Colunga, Ricardo Pires das Neves, Antonio Martinez-Lorente, Fernando Almazán, Raúl Guantes & Francisco J. Iborra

Joo-Young Kim, Young-Mi Kim, Jong-Min Park, Young Min Han, Kang Choon Lee, Ki Baik Hahm,  and  Suntaek Hong

RIPK1, necroptosis

Ca2+-dependent demethylation of phosphatase PP2Ac promotes glucose deprivation-induced cell death independently of inhibiting glycolysis
Ha Yin Lee , Yoko Itahana, Stefan Schuechner, Masahiro Fukuda, H. Shawn Je, Egon Ogris, David M. Virshup, Koji Itahana

RIP3 targets pyruvate dehydrogenase complex to increase aerobic respiration in TNF-induced necroptosis
Zhentao Yang , Yan Wang ,Yingying Zhang , Xiadi He, Chuan-Qi Zhong ,Hengxiao Ni , Xin Chen , Yaoji Liang , Jianfeng Wu , Shimin Zhao , Dawang Zhou & Jiahuai Han


Resolvins suppress tumor growth and enhance cancer therapy
Megan L. Sulciner, Charles N. Serhan, Molly M. Gilligan, Dayna K. Mudge, Jaimie Chang, Allison Gartung, Kristen A. Lehner, Diane R. Bielenberg, Birgitta Schmidt, Jesmond Dalli, Emily R. Greene, Yael Gus-Brautbar, Julia Piwowarski, Tadanori Mammoto, David Zurakowski, Mauro Perretti, Vikas P. Sukhatme, Arja Kaipainen, Mark W. Kieran, Sui Huang and Dipak Panigrahy

Apoptosis-induced CXCL5 accelerates inflammation and growth of prostate tumor metastases in bone
Hernan Roca, Jacqueline D. Jones, Marta C. Purica, Savannah Weidner, Amy J. Koh, Robert Kuo, John E. Wilkinson, Yugang Wang, Stephanie Daignault-Newton, Kenneth J. Pienta, Todd M. Morgan, Evan T. Keller, Jacques E. Nör, Lonnie D. Shea, and Laurie K. McCauley


Selenium Utilization by GPX4 Is Required to Prevent Hydroperoxide-Induced Ferroptosis
Irina Ingold, Carsten Berndt, Sabine Schmitt, Sebastian Doll, Gereon Poschmann, Katalin Buday, Antonella Roveri, Xiaoxiao Peng, Florencio Porto Freitas, Tobias Seibt, Lisa Mehr, Michaela Aichler, Axel Walch, Daniel Lamp, Martin Jastroch, Sayuri Miyamoto, Wolfgang Wurst, Fulvio Ursini, Elias S.J. Arnér, Noelia Fradejas-Villar, Ulrich Schweizer, Hans Zischka, José Pedro Friedmann Angeli, Marcus Conrad

The unique histidine in OSCP subunit of F‐ATP synthase mediates inhibition of the permeability transition pore by acidic pH
Manuela Antoniel, Kristen Jones, Salvatore Antonucci, Barbara Spolaore, Federico Fogolari, Valeria Petronilli, Valentina Giorgio, Michela Carraro, Fabio Di Lisa, Michael Forte, Ildikó Szabó, Giovanna Lippe and Paolo Bernardi

The Pore-Forming Protein Gasdermin D Regulates Interleukin-1 Secretion from Living Macrophages
Charles L. Evavold, Jianbin Ruan, Yunhao Tan, Shiyu Xia, Hao Wu, Jonathan C. Kagan

CDK9‐mediated phosphorylation controls the interaction of TIP60 with the transcriptional machinery
Prisca Brauns‐Schubert, Florian Schubert, Manuela Wissler, Martina Weiss,Lisa Schlicher, Simon Bessler, Mariam Safavi, Cornelius Miething, Christoph Borner, Tilman Brummer and Ulrich Maurer

Oxeiptosis, a ROS-induced caspase-independent apoptosis-like cell-death pathway
Cathleen Holze, Chloé Michaudel, Claire Mackowiak, Darya A. Haas, Christian Benda et al.


Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018.
Galluzzi L, et al

Structural principles of tumor necrosis factor superfamily signaling
Éva S. Vanamee , Denise L. Faustman

Evolution of Voltage-Dependent Anion Channel Function: From Molecular Sieve to Governator to Actuator of Ferroptosis
John J. Lemasters

Mechanisms of redox metabolism and cancer cell survival during extracellular matrix detachment
Mark A Hawk and Zachary T Schafer


Bcl-2 proteins: Unraveling the details of a complex and dynamic network
Stephanie Bleicken & Ana J. Garcia-Saez

Resolving the dark side of therapy-driven cancer cell death
Eduardo Bonavita, Victoria S. Pelly and Santiago Zelenay

An Element of Life
Douglas R. Green

Apoptotic Regulatory T Cells Retain Suppressive Function through Adenosine
Ulf H. Beier

To die or not to die: Regulatory feedback phosphorylation circuits determine receptor-interacting protein kinase-1 (RIPK1) function
Manoj B. Menon, Julia Gropengießer, Klaus Ruckdeschel & Matthias Gaestel

Switching from TNF-induced inflammation to death signaling
Qing Xu, Swati Choksi & Zhengang Liu

Gasdermin D Flashes an Exit Signal for IL-1
Teneema Kuriakose, Thirumala-Devi Kanneganti

Stressed-out ROS take a silent death route
Sannula Kesavardhana & Thirumala-Devi Kanneganti

Pulling the BAX trigger for tumor cell death
Denis E. Reyna and Evripidis Gavathiotis

Novel drug combination unleashes apoptosis in AML

Journal Club: Mitochondria: back to the future
Navdeep S. Chandel

Janet A. Houghton, PhD: In Memoriam (1952–2017)
Mark J. Suto



ApoList – December 2017

Bcl-2 family proteins

Targeted apoptosis of myofibroblasts with the BH3 mimetic ABT-263 reverses established fibrosis
David Lagares , Alba Santos, Paula E. Grasberger, Fei Liu, Clemens K. Probst, Rod A. Rahimi, Norihiko Sakai, Tobias Kuehl, Jeremy Ryan, Patrick Bhola, Joan Montero, Mohit Kapoor, Murray Baron, Xaralabos Varelas, Daniel J. Tschumperlin, Anthony Letai, Andrew M. Tager

BOK promotes chemical-induced hepatocarcinogenesis in mice
Tatiana Rabachini, Yuniel Fernandez-Marrero, Matteo Montani, Giulio Loforese, Valentina Sladky, Zhaoyue He, Daniel Bachmann, Simone Wicki, Andreas Villunger, Deborah Stroka & Thomas Kaufmann

First-in-human response of BCL-2 inhibitor venetoclax in T-cell prolymphocytic leukemia
Bernd Boidol, Christoph Kornauth, Emiel van der Kouwe, Nicole Prutsch, Lukas Kazianka, Sinan Gültekin, Gregor Hoermann, Marius E. Mayerhoefer, Georg Hopfinger, Alexander Hauswirth, Michael Panny, Marie-Bernadette Aretin, Bernadette Hilgarth, Wolfgang R. Sperr, Peter Valent, Ingrid Simonitsch-Klupp, Richard Moriggl, Olaf Merkel, Lukas Kenner, Ulrich Jäger, Stefan Kubicek and Philipp B. Staber

Synthetic Lethality of Combined Bcl-2 Inhibition and p53 Activation in AML: Mechanisms and Superior Antileukemic Efficacy
Rongqing Pan, Vivian Ruvolo, Hong Mu, Joel D. Leverson, Gwen Nichols, John C. Reed, Marina Konopleva, Michael Andreeff

Tamara Vervloessem, Haidar Akl, Thomas Tousseyn, Humbert De Smedt, Jan B. Parys,  and  Geert Bultynck

A critical epithelial survival axis regulated by MCL-1 maintains thymic function in mice
Reema Jain, Julie M. Sheridan, Antonia Policheni, Melanie Heinlein, Luke C. Gandolfo, Grant Dewson, Gordon K. Smyth, Stephen N. Sansom, Nai Yang Fu, Jane E. Visvader, Georg A. Holländer, Andreas Strasser and Daniel H. D. Gray

Jianqing Lin, Deqiang Fu, Yijun Dai, Jianguang Lin,  and  Tianwen Xu

Golgi stress–induced transcriptional changes mediated by MAPK signaling and three ETS transcription factors regulate MCL1 splicing
Jan Baumann, Tatiana I. Ignashkova, Sridhar R. Chirasani, Silvia Ramírez-Peinado, Hamed Alborzinia, Mathieu Gendarme, Kyra Kuhnigk, Valentin Kramer, Ralph K. Lindemann and Jan H. Reiling

Involvement of proapoptotic genes in autophagic cell death induced by irradiation
Jianrui Song, Xue Zhao, Yi Feng, Sheng Xu, Yanling Zhang & Lixin Wei

Death receptors / cFLIP

A variant of death-receptor 3 associated with rheumatoid arthritis interferes with apoptosis-induction of T cell.
Akira Hashiramoto, Yoshitake Konishi, Koichi Murayama, Hiroki Kawasaki, Kosuke Yoshida, Ken Tsumiyama, Kimie Tanaka, Masaru Mizuhara, Toshio Shiotsuki, Hitomi Kitamura, Koichiro Komai, Tomoatsu Kimura, Hideo Yagita, Kazuko Shiozawa and Shunichi Shiozawa

Cellular FLIP long isoform (cFLIPL)-IKKα interactions inhibit IRF7 activation, representing a new cellular strategy to inhibit IFNα expression.
Lauren T Gates-Tanzer and Joanna L Shisler

ST6Gal-I sialyltransferase promotes tumor necrosis factor (TNF)-mediated cancer cell survival via sialylation of the TNF receptor 1 (TNFR1) death receptor
Andrew T. Holdbrooks, Colleen M. Britain and Susan L. Bellis

Necroptosis / ferroptosis

Very Long Chain Fatty Acids Are Functionally Involved in Necroptosis
Laura R. Parisi, Nas Li, G. Ekin Atilla-Gokcumen

ΔNp63 Inhibits Oxidative Stress-Induced Cell Death, Including Ferroptosis, and Cooperates with the BCL-2 Family to Promote Clonogenic Survival
Gary X. Wang, Ho-Chou Tu, Yiyu Dong, Anders Jacobsen Skanderup, Yufeng Wang, Shugaku Takeda, Yogesh Tengarai Ganesan, Song Han, Han Liu, James J. Hsieh, Emily H. Cheng

Inflammasome / apoptosis or pyroptosis

The Inflammasome Drives GSDMD-Independent Secondary Pyroptosis and IL-1 Release in the Absence of Caspase-1 Protease Activity
Katharina S. Schneider, Christina J. Groß, Roland F. Dreier, Benedikt S. Saller, Ritu Mishra, Oliver Gorka, Rosalie Heilig, Etienne Meunier, Mathias S. Dick, Tamara Ćiković, Jan Sodenkamp, Guillaume Médard, Ronald Naumann, Jürgen Ruland, Bernhard Kuster, Petr Broz, Olaf Groß

Caspase-1 Engagement and TLR-Induced c-FLIP Expression Suppress ASC/Caspase-8-Dependent Apoptosis by Inflammasome Sensors NLRP1b and NLRC4
Nina Van Opdenbosch, Hanne Van Gorp, Maarten Verdonckt, Pedro H.V. Saavedra, Nathalia M. de Vasconcelos, Amanda Gonçalves, Lieselotte Vande Walle, Dieter Demon, Magdalena Matusiak, Filip Van Hauwermeiren, Jinke D’Hont, Tino Hochepied, Stefan Krautwald, Thirumala-Devi Kanneganti, Mohamed Lamkanfi

Gasdermin D plays a key role as a pyroptosis executor of non-alcoholic steatohepatitis in humans and mice
Bing Xua , Mingzuo Jianga , Yi Chua , Weijie Wanga , Di Chen , Xiaowei Li , Zhao Zhang , Di Zhang , Daiming Fan , Yongzhan Nie , Feng Shao , Kaichun Wu, Jie Liang


X-Linked Inhibitor of Apoptosis Protein (XIAP) is a Client of Heat Shock Protein 70 (Hsp70) and a Biomarker of its Inhibition
Laura C Cesa, Hao Shao, Sharan R Srinivasan, Eric Tse, Chetali Jain, Erik R.P. Zuiderweg, Daniel R Southworth, Anna K Mapp and Jason E Gestwicki


Found in Translation: How Preclinical Research Is Guiding the Clinical Development of the BCL2-Selective Inhibitor Venetoclax
Joel D. Leverson, Deepak Sampath, Andrew J. Souers, Saul H. Rosenberg, Wayne J. Fairbrother, Martine Amiot, Marina Konopleva and Anthony Letai

Paving TRAIL’s Path with Ubiquitin
Elodie Lafont, Torsten Hartwig, Henning Walczak

Sphingolipid metabolism in cancer signalling and therapy
Besim Ogretmen

Control of cell death and mitochondrial fission by ERK1/2 MAP kinase signalling
Simon J. Cook, Kate Stuart, Rebecca Gilley, Matthew J. Sale

Therapeutic opportunities based on caspase modulation.
Simone Fulda


T-PLL: another check on the venetoclax list?
Prithviraj Bose and Marina Y. Konopleva

MCL-1 keeps a charming home for thymocytes
Xuguang Tai

BTSA1 Activates BAX to Promote Apoptosis in Acute Myeloid Leukemia

ApoList – November 2017

Bcl-2 family proteins

The combination of reduced MCL-1 and standard chemotherapeutics is tolerable in mice
Kerstin Brinkmann, Stephanie Grabow, Craig D Hyland, Charis E Teh, Warren S Alexander, Marco J Herold and Andreas Strasser

Modulation of Navitoclax Sensitivity by Dihydroartemisinin-Mediated MCL-1 Repression in BCR-ABL+ B-Lineage Acute Lymphoblastic Leukemia
Amit Budhraja, Meghan E Turnis, Michelle L Churchman, Anisha Kothari, Xue Yang, Haiyan Xu, Ewa Kaminska, John C Panetta, David Finkelstein, Charles G. Mullighan and Joseph T Opferman

Autophagic cell death is dependent on lysosomal membrane permeability through Bax and Bak
Jason Karch, Tobias G Schips, Bryan D Maliken, Matthew J Brody, Michelle A Sargent, Onur Kanisciak and Jeffery D Molkentin

Venetoclax is effective in small cell lung cancers with high BCL-2 expression
Timothy L Lochmann, Konstantinos V Floros, Mitra Naseri, Krista M Powell, Wade Cook, Ryan J March, Giovanna T Stein, Patricia Greninger, Yuki Kato Maves, Laura R Saunders, Scott J. Dylla, Carlotta Costa, Sosipatros A Boikos, Joel D. Leverson, Andrew J. Souers, Geoffrey W Krystal, Hisashi Harada, Cyril H. Benes and Anthony C. Faber

BCL-2 system analysis identifies high-risk colorectal cancer patients.
Lindner AU, Salvucci M, Morgan C, Monsefi N, Resler AJ, Cremona M, Curry S, Toomey S, O’Byrne R, Bacon O, Stühler M, Flanagan L, Wilson R, Johnston PG, Salto-Tellez M, Camilleri-Broët S, McNamara DA, Kay EW, Hennessy BT, Laurent-Puig P, Van Schaeybroeck S, Prehn JHM.

c-FLIP / caspases

PELI1 functions as a dual modulator of necroptosis and apoptosis by regulating ubiquitination of RIPK1 and mRNA levels of c-FLIP
Huibing Wang, Huyan Meng, Xingyan Li, Kezhou Zhu, Kangyun Dong, Adnan K. Mookhtiar, Huiting Wei, Ying Li, Shao-Cong Sun, and Junying Yuan

Oncogenic p95HER2/611CTF primes human breast epithelial cells for metabolic stress-induced down-regulation of FLIP and activation of TRAIL-R/Caspase-8-dependent apoptosis
Rosa Martín-Pérez, Rosario Yerbes, Rocío Mora-Molina, Ana Cano-González, Joaquín Arribas, Massimiliano Mazzone, Abelardo López-Rivas and Carmen Palacios

Chandrasekhar Padmanabhan, Eric J. Rellinger, Jing Zhu, Hanbing An, Luke G. Woodbury, Dai H. Chung, Alex G. Waterson, Craig W. Lindsley, Anna L. Means, and  R. Daniel Beauchamp

Active-site adjacent phosphorylation at Tyr-397 by c-Abl kinase inactivates caspase-9
Banyuhay P. Serrano, Hannah S. Szydlo, Dominique R. Alfandari and Jeanne A. Hardy

Death receptors

Resistance to cancer immunotherapy mediated by apoptosis of tumor-infiltrating lymphocytes
Jingjing Zhu, Céline G. Powis de Tenbossche, Stefania Cané, Didier Colau, Nicolas van Baren, Christophe Lurquin, Anne-Marie Schmitt-Verhulst, Peter Liljeström, Catherine Uyttenhove & Benoit J. Van den Eynde

TAK1 inhibition subverts the osteoclastogenic action of TRAIL while potentiating its antimyeloma effects
Hirofumi Tenshin, Jumpei Teramachi, Asuka Oda, Ryota Amachi, Masahiro Hiasa, Ariunzaya Bat-Erdene, Keiichiro Watanabe, Masami Iwasa, Takeshi Harada, Shiro Fujii, Kumiko Kagawa, Kimiko Sogabe, Shingen Nakamura, Hirokazu Miki, Kiyoe Kurahashi, Sumiko Yoshida, Kenichi Aihara, Itsuro Endo, Eiji Tanaka, Toshio Matsumoto and Masahiro Abe

A variant of death-receptor 3 associated with rheumatoid arthritis interferes with apoptosis-induction of T cell.
Akira Hashiramoto, Yoshitake Konishi, Koichi Maruyama, Hiroki Kawasaki, Kosuke Yoshida, Ken Tsumiyama, Kimie Tanaka, Masaru Mizuhara, Toshio Shiotsuki, Hitomi Kitamura, Koichiro Komai, Tomoatsu Kimura, Hideo Yagita, Kazuko Shiozawa and Shunichi Shiozawa

RIPK1, necroptosis

RIPK1-dependent apoptosis bypasses pathogen blockade of innate signaling to promote immune defense
Lance W. Peterson, Naomi H. Philip, Alexandra DeLaney, Meghan A. Wynosky-Dolfi, Kendra Asklof, Falon Gray, Ruth Choa, Elisabet Bjanes, Elisabeth L. Buza, Baofeng Hu, Christopher P. Dillon, Douglas R. Green, Scott B. Berger, Peter J. Gough, John Bertin and Igor E. Brodsky

Necroptosis controls NET generation and mediates complement activation, endothelial damage, and autoimmune vasculitis
Adrian Schreiber, Anthony Rousselle, Jan Ulrich Becker, Anne von Mässenhausen, Andreas Linkermann, and Ralph Kettritz

Non apoptotic cell death

Caspase-11–mediated endothelial pyroptosis underlies endotoxemia-induced lung injury
Kwong Tai Cheng, Shiqin Xiong, Zhiming Ye, Zhigang Hong, Anke Di, Kit Man Tsang, Xiaopei Gao, Shejuan An, Manish Mittal, Stephen M. Vogel, Edward A. Miao, Jalees Rehman, Asrar B. Malik

Cold stress‐induced ferroptosis involves the ASK1‐p38 pathway
Kazuki Hattori, Hiroyuki Ishikawa, Chihiro Sakauchi, Saki Takayanagi, Isao Naguro and Hidenori Ichijo

Cell death and cell lysis are separable events during pyroptosis
Lucian DiPeso, Daisy X Ji, Russell E Vance & Jordan V Price


Tissue-Resident Macrophages Are Locally Programmed for Silent Clearance of Apoptotic Cells
Allison W. Roberts, Bettina L. Lee, Jacques Deguine, Shinu John, Mark J. Shlomchik, Gregory M. Barton

Apoptosis in mesenchymal stromal cells induces in vivo recipient-mediated immunomodulation
Antonio Galleu , Yanira Riffo-Vasquez, Cristina Trento, Cara Lomas, Luigi Dolcetti, Tik Shing Cheung, Malte von Bonin, Laura Barbieri, Krishma Halai, Sophie Ward, Ling Weng, Ronjon Chakraverty, Giovanna Lombardi, Fiona M. Watt, Kim Orchard, David I. Marks, Jane Apperley, Martin Bornhauser, Henning Walczak, Clare Bennett, Francesco Dazzi

Cytoplasmic p53 couples oncogene-driven glucose metabolism to apoptosis and is a therapeutic target in glioblastoma
Wilson X Mai, Laura Gosa, Veerle W Daniels, Lisa Ta, Jonathan E Tsang, Brian Higgins, W Blake Gilmore, Nicholas A Bayley, Mitra Dehghan Harati, Jason T Lee, William H Yong, Harley I Kornblum, Steven J Bensinger, Paul S Mischel, P Nagesh Rao, Peter M Clark, Timothy F Cloughesy, Anthony Letai & David A Nathanson

Defining external factors that determine neuronal survival, apoptosis and necrosis during excitotoxic injury using a high content screening imaging platform
Ujval Anilkumar, Petronela Weisova, Jasmin Schmid, Tytus Bernas, Heinrich J. Huber, Heiko Düssmann, Niamh M. C. Connolly, Jochen H. M. Prehn

Granzyme B Disrupts Central Metabolism and Protein Synthesis in Bacteria to Promote an Immune Cell Death Program
Farokh Dotiwala, Sumit Sen Santara, Andres Ariel Binker-Cosen, Bo Li, Sriram Chandrasekaran, Judy Lieberman


How do we fit ferroptosis in the family of regulated cell death?
Howard O Fearnhead, Peter Vandenabeele and Tom Vanden Berghe

The resurrection of the PIDDosome – emerging roles in the DNA-damage response and centrosome surveillanc
Valentina Sladky, Fabian Schuler, Luca L. Fava and Andreas Villunger

Q&A: Cellular near death experiences—what is anastasis?
Gongping Sun and Denise J. Montell

Inhibitors of apoptosis: clinical implications in cancer
Mervat S. Mohamed, Mai K. Bishr, Fahad M. Almutairi & Ayat G. Ali

Conserved nucleolar stress at the onset of cell death
Pierre Golstein

Inflammasome activation and assembly at a glance
Ankit Malik and Thirumala-Devi Kanneganti

Special issue in “Cell Calcium” on Ca++ and cell death
– Preface: Ca2+ signaling and cell death: Focus on the role of Ca2+ signals in the regulation of cell death & survival processes in health, disease and therapy
– Editorial:Ca2+ signaling and cell death: Focus on Ca2+-transport systems and their implication in cell death and survival
Jan B. Parys, Geert Bultynck

Comments / other

Apoptotic debris goes in the Bim
Lack of Bim expression in myeloid cells induces lupus nephritis in mice

The Silent Undertakers: Macrophages Programmed for Efferocytosis
Judith E. Allen, Dominik Rückerl

Caspase-independent cell death: an anti-cancer double-whammy
Evangelos Giampazolias & Stephen W.G. Tait

The Ferrous Awakens
Andrew J. Rennekamp

ApoList – October 2017

Bcl-2 family proteins

BCL-XL directly modulates RAS signalling to favour cancer cell stemness
Sophie de Carné Trécesson, Frédérique Souazé, Agnès Basseville, Anne-Charlotte Bernard, Jessie Pécot, Jonathan Lopez, Margaux Bessou, Kristopher A. Sarosiek, Anthony Letai, Sophie Barillé-Nion, Isabelle Valo, Olivier Coqueret, Catherine Guette, Mario Campone, Fabien Gautier & Philippe Paul Juin

MYC and MCL1 Cooperatively Promote Chemotherapy-Resistant Breast Cancer Stem Cells via Regulation of Mitochondrial Oxidative Phosphorylation
Kyung-min Lee, Jennifer M. Giltnane, Justin M. Balko, Luis J. Schwarz, Angel L. Guerrero-Zotano, Katherine E. Hutchinson, Mellissa J. Nixon, Mónica V. Estrada, Violeta Sánchez, Melinda E. Sanders, Taekyu Lee, Henry Gómez, Ana Lluch, J. Alejandro Pérez-Fidalgo, Melissa Magdalene Wolf, Gabriela Andrejeva, Jeffrey C. Rathmell, Stephen W. Fesik, Carlos L. Arteaga

Dynein light chain 1 induces assembly of large Bim complexes on mitochondria that stabilize Mcl-1 and regulate apoptosis
Prafull Kumar Singh, Aristomenis Roukounakis, Daniel O. Frank, Susanne Kirschnek, Kushal Kumar Das, Simon Neumann, Josef Madl, Winfried Römer, Carina Zorzin, Christoph Borner, Aladin Haimovici, Ana Garcia-Saez, Arnim Weber and Georg Häcker

Direct Activation of BAX by BTSA1 Overcomes Apoptosis Resistance in Acute Myeloid Leukemia
Denis E. Reyna, Thomas P. Garner, Andrea Lopez, Felix Kopp, Gaurav S. Choudhary, Ashwin Sridharan, Swathi-Rao Narayanagari, Kelly Mitchell, Baoxia Dong, Boris A. Bartholdy, Loren D. Walensky, Amit Verma, Ulrich Steidl, Evripidis Gavathiotis

Bik reduces hyperplastic cells by increasing Bak and activating DAPk1 to juxtapose ER and mitochondria
Yohannes A. Mebratu, Ivan Leyva-Baca, Marc G. Wathelet, Neal Lacey, Hitendra S. Chand, Augustine M. K. Choi & Yohannes Tesfaigzi

Inhibition of Bcl-xL prevents pro-death actions of ΔN-Bcl-xL at the mitochondrial inner membrane during glutamate excitotoxicity
Han-A Park, Pawel Licznerski, Nelli Mnatsakanyan, Yulong Niu, Silvio Sacchetti, Jing Wu, Brian M Polster, Kambiz N Alavian and Elizabeth A Jonas

Induction of synthetic lethality in IDH1-mutated gliomas through inhibition of Bcl-xL
Georg Karpel-Massler, Chiaki Tsuge Ishida, Elena Bianchetti, Yiru Zhang, Chang Shu, Takashi Tsujiuchi, Matei A. Banu, Franklin Garcia, Kevin A. Roth, Jeffrey N. Bruce, Peter Canoll & Markus D. Siegelin

Degradation of Bcl-2 by XIAP and ARTS Promotes Apoptosis
Natalia Edison, Yael Curtz, Nicole Paland, Dana Mamriev, Nicolas Chorubczyk, Tali Haviv-Reingewertz, Nir Kfir, David Morgenstern, Meital Kupervaser, Juliana Kagan, Hyoung Tae Kim, Sarit Larisch

Loss of BIM augments resistance of ATM-deficient thymocytes to DNA damage-induced apoptosis but does not accelerate lymphoma development
Alex RD Delbridge, Stephanie Grabow and Andreas Strasser

Benjamin Onyeagucha, Panneerdoss Subbarayalu, Nourhan Abdelfattah, Subapriya Rajamanickam, Santosh Timilsina, Rosa Guzman, Vijay Eedunuri, Sanjay Bansal, Tabrez Mohammad, Yidong Chen, Ratna K. Vadlamudi, and  Manjeet K. Rao

NCoR1 restrains thymic negative selection by repressing Bim expression to spare thymocytes undergoing positive selection
Jianrong Wang, Nanhai He, Na Zhang, Dexian Quan, Shuo Zhang, Caroline Zhang, Ruth T. Yu, Annette R. Atkins, Ruihong Zhu, Chunhui Yang, Ying Cui, Christopher Liddle, Michael Downes, Hui Xiao, Ye Zheng, Johan Auwerx, Ronald M. Evans & Qibin Leng

Enhancing venetoclax activity in acute myeloid leukemia by co-targeting MCL1.
T-C Teh, N-Y Nguyen, D M Moujalled, D Segal, G Pomilio, S Rijal, A Jabbour, K Cummins, K Lackovic, P Blombery, E Thompson, P G Ekert, G Lessene, S P Glaser, D C S Huang, A W Roberts, M A Guthridge &A H Wei

Death receptors

Secretory stressors induce intracellular death receptor accumulation to control apoptosis
Bram J van Raam, Tamara Lacina, Ralph K Lindemann and Jan H Reiling

Executioner caspases and CAD are essential for mutagenesis induced by TRAIL or vincristine.
Mark A Miles and Christine J Hawkins

The Btk-dependent PIP5K1γ lipid kinase activation by Fas counteracts FasL-induced cell death
Aurélie Rossin, Nadia Lounnas, Jérôme Durivault, Giorgia Miloro, Laurent Gagnoux-Palacios & Anne-Odile Hueber

Many si/shRNAs can kill cancer cells by targeting multiple survival genes through an off-target mechanism
William Putzbach, Quan Q Gao, Monal Patel, Stijn van Dongen, Ashley Haluck-Kangas, Aishe A Sarshad, Elizabeth T Bartom, Kwang-Youn A Kim, Denise M Scholtens, Markus Hafner, Jonathan C Zhao, Andrea E Murmann and Marcus E Peter

Caspases and IAPs

Caspase-2 deficiency enhances whole-body carbohydrate utilisation and prevents high-fat diet-induced obesity
Claire H Wilson, Andrej Nikolic, Stephen J Kentish, Marianne Keller, George Hatzinikolas, Loretta Dorstyn, Amanda J Page and Sharad Kumar

Mass Cytometric Analysis Reveals Viable Activated Caspase-3+ Luminal Progenitors in the Normal Adult Human Mammary Gland
David J.H.F. Knapp, Nagarajan Kannan, Davide Pellacani, Connie J. Eaves

Identification and validation of uterine stimulant methylergometrine as a potential inhibitor of caspase-1 activation
Guillermo García-Laínez, Mónica Sancho, Vanessa García-Bayarri & Mar Orzáez

Caspase-1 cleaves PPARγ for potentiating the pro-tumor action of TAMs
Zhiyuan Niu, Qian Shi, Wenlong Zhang, Yuxin Shu, Nanfei Yang, Bing Chen, Qingsong Wang, Xuyang Zhao, Jiajia Chen, Nan Cheng, Xiujing Feng, Zichun Hua, Jianguo Ji & Pingping Shen

Modulation of apoptotic response by LAR family phosphatases–cIAP1 signaling during urinary tract morphogenesis
Katherine Stewart, You Chi Tang, Maxwell E. R. Shafer, Adda-Lee Graham-Paquin, and Maxime Bouchard

Inhibition of Caspase-8 does not protect from alcohol-induced liver apoptosis but alleviates alcoholic hepatic steatosis in mice
Fengjie Hao, Francisco Javier Cubero, Pierluigi Ramadori, Lijun Liao, Ute Haas, Daniela Lambertz, Roland Sonntag, Jörg- Martin Bangen, Nikolaus Gassler, Mareike Hoss, Konrad L Streetz, Johanna Reissing, Henning W Zimmermann, Christian Trautwein, Christian Liedtke and Yulia A Nevzorova

Non-apoptotic cell death

PEBP1 Wardens Ferroptosis by Enabling Lipoxygenase Generation of Lipid Death Signals
Sally E. Wenzel, Yulia Y. Tyurina, Jinming Zhao, Claudette M. St. Croix, Haider H. Dar, Gaowei Mao, Vladimir A. Tyurin, Tamil S. Anthonymuthu, Alexandr A. Kapralov, Andrew A. Amoscato, Karolina Mikulska-Ruminska, Indira H. Shrivastava, Elizabeth M. Kenny, Qin Yang, Joel C. Rosenbaum, Louis J. Sparvero, David R. Emlet, Xiaoyan Wen, Yoshinori Minami, Feng Qu, Simon C. Watkins, Theodore R. Holman, Andrew P. VanDemark, John A. Kellum, Ivet Bahar, Hülya Bayır, Valerian E. Kagan

p53-dependent programmed necrosis controls germ cell homeostasis during spermatogenesis
Francesco Napoletano, Benjamin Gibert, Keren Yacobi-Sharon, Stéphane Vincent, Clémentine Favrot, Patrick Mehlen, Victor Girard, Margaux Teil, Gilles Chatelain, Ludivine Walter, Eli Arama, Bertrand Mollereau

Structure insight of GSDMD reveals the basis of GSDMD autoinhibition in cell pyroptosis
Siyun Kuang, Jun Zheng, Hui Yang, Suhua Li, Shuyan Duan, Yanfang Shen, Chaoneng Ji, Jianhua Gan, Xue-Wei Xu, and Jixi Li

ATF4 promotes angiogenesis and neuronal cell death and confers ferroptosis in a xCT-dependent manner
D Chen, Z Fan, M Rauh, M Buchfelder, I Y Eyupoglu and N Savaskan

Inhibition of DAI-dependent necroptosis by the Z-DNA binding domain of the vaccinia virus innate immune evasion protein, E3
Heather Koehler, Samantha Cotsmire, Jeffrey Langland, Karen V. Kibler, Daniel Kalman, Jason W. Upton, Edward S. Mocarski, and Bertram L. Jacobs


Mitochondrial Fission Promotes the Continued Clearance of Apoptotic Cells by Macrophages
Ying Wang, Manikandan Subramanian, Arif Yurdagul Jr., Valéria C. Barbosa-Lorenzi, Bishuang Cai, Jaime de Juan-Sanz, Timothy A. Ryan, Masatoshi Nomura, Frederick R. Maxfield, Ira Tabas

The microanatomic segregation of selection by apoptosis in the germinal center
By Christian T. Mayer, Anna Gazumyan, Ervin E. Kara, Alexander D. Gitlin, Jovana Golijanin, Charlotte Viant, Joy Pai, Thiago Y. Oliveira, Qiao Wang, Amelia Escolano, Max Medina-Ramirez, Rogier W. Sanders, Michel C. Nussenzweig

The Rice Dynamin-Related Protein OsDRP1E Negatively Regulates Programmed Cell Death by Controlling the Release of Cytochrome c from Mitochondria
Zhiqiang Li, Bo Ding , Xueping Zhou, Guo-Liang Wang

The proline rich domain of p53 is dispensable for MGMT-dependent DNA repair and cell survival following alkylation damage
Katherine Baran, Mao Yang, Christopher P Dillon, Leona L Samson and Douglas R Green

RIPK1 mediates a disease-associated microglial response in Alzheimer’s disease
Dimitry Ofengeim, Sonia Mazzitelli, Yasushi Ito, Judy Park DeWitt, Lauren Mifflin, Chengyu Zou, Sudeshna Das, Xian Adiconis, Hongbo Chen, Hong Zhu, Michelle A. Kelliher, Joshua Z. Levin, and Junying Yuan


Ferroptosis: A Regulated Cell Death Nexus Linking Metabolism, Redox Biology, and Disease
Brent R. Stockwell, José Pedro Friedmann Angeli, Hülya Bayir, Ashley I. Bush, Marcus Conrad, Scott J. Dixon, Simone Fulda, Sergio Gascón, Stavroula K. Hatzios, Valerian E. Kagan, Kay Noel, Xuejun Jiang, Andreas Linkermann, Maureen E. Murphy, Michael Overholtzer, Atsushi Oyagi, Gabriela C. Pagnussat, Jason Park, Qitao Ran, Craig S. Rosenfeld, Konstantin Salnikow, Daolin Tang, Frank M. Torti, Suzy V. Torti, Shinya Toyokuni, K.A. Woerpel, Donna D. Zhang

Apoptosis and Necroptosis as Host Defense Strategies to Prevent Viral Infection
Megan H. Orzalli, Jonathan C. Kagan

The immune response to secondary necrotic cells
Monika Sachet, Ying Yu Liang & Rudolf Oehler

CD95/Fas, Non-Apoptotic Signaling Pathways, and Kinases
Matthieu Le Gallo, Amanda Poissonnier, Patrick Blanco and Patrick Legembre

Targeting apoptosis in acute myeloid leukaemia
Philippe A Cassier, Marie Castets, Amine Belhabri and Norbert Vey

Therapeutics targeting Bcl-2 in hematological malignancies
Astrid Ruefli-Brasse and John C. Reed


Direct pro-apoptotic role for NPM1 as a regulator of PIDDosome formation
Samuel Sidi & Lisa Bouchier-Hayes

Apoptosis, Up the Ante
Palaniraja Thandapani, Iannis Aifantis

Cell death: BCL-2 proteins feed their own expression


ApoList – September 2017

Bcl-2 family proteins

Transient apoptosis inhibition in donor stem cells improves hematopoietic stem cell transplantation
Matthias Kollek, Gesina Voigt, Christian Molnar, Fabronia Murad, Daniela Bertele, Christopher Felix Krombholz, Sheila Bohler, Verena Labi, Stefan Schiller, Mirjam Kunze, Stephan Geley, Charlotte M. Niemeyer, Ana Garcia-Saez, Miriam Erlacher

Extra-mitochondrial prosurvival BCL-2 proteins regulate gene transcription by inhibiting the SUFU tumour suppressor
Xiaofeng Wu, Li-shu Zhang, Jason Toombs, Yi-Chun Kuo, John Tyler Piazza, Rubina Tuladhar, Quinn Barrett, Chih-wei Fan, Xuewu Zhang, Loren D. Walensky, Marcel Kool, Steven Y. Cheng, Rolf Brekken, Joseph T. Opferman, Douglas R. Green, Tudor Moldoveanu & Lawrence Lum

Parkin promotes proteasomal degradation of misregulated BAX
Zeynep Cakir, Kathrin Funk, Joachim Lauterwasser, Franziska Todt, Ralf M. Zerbes, Aline Oelgeklaus, Atsushi Tanaka, Martin van der Laan and Frank Edlich

The Cdk5-Mcl-1 axis promotes mitochondrial dysfunction and neurodegeneration in a model of Alzheimer’s disease
Kumar Nikhil and Kavita Shah

Live-cell imaging to measure BAX recruitment kinetics to mitochondria during apoptosis
Margaret E. Maes, Cassandra L. Schlamp, Robert W. Nickells

ERK1/2 signalling protects against apoptosis following endoplasmic reticulum stress but cannot provide long-term protection against BAX/BAK-independent cell death
Nicola J. Darling , Kathryn Balmanno, Simon J. Cook

p53-mediated suppression of BiP triggers BIK-induced apoptosis during prolonged endoplasmic reticulum stress
Ignacio López, Anne-Sophie Tournillon, Rodrigo Prado Martins, Konstantinos Karakostis, Laurence Malbert-Colas, Karin Nylander and Robin Fåhraeus

Death receptors and IAPs

MK2 phosphorylation of RIPK1 regulates TNF-mediated cell death
Yves Dondelinger, Tom Delanghe, Diego Rojas-Rivera, Dario Priem, Tinneke Delvaeye, Inge Bruggeman, Franky Van Herreweghe, Peter Vandenabeele & Mathieu J. M. Bertrand

p38MAPK/MK2-dependent phosphorylation controls cytotoxic RIPK1 signalling in inflammation and infection
Manoj B. Menon, Julia Gropengießer, Jessica Fischer, Lena Novikova, Anne Deuretzbacher, Juri Lafera, Hanna Schimmeck, Nicole Czymmeck, Natalia Ronkina, Alexey Kotlyarov, Martin Aepfelbacher, Matthias Gaestel & Klaus Ruckdeschel

The bacterial arginine glycosyltransferase effector NleB preferentially modifies Fas-associated death domain protein (FADD).
Nichollas E Scott, Cristina Giogha, Georgina L Pollock, Catherine L Kennedy, Andrew I Webb, Nicholas A Williamson, Jaclyn S Pearson and Elizabeth L Hartland

PD-L1 and IAPs co-operate to protect tumors from cytotoxic lymphocyte-derived TNF
Conor J Kearney, Najoua Lalaoui, Andrew J Freeman, Kelly M Ramsbottom, John Silke and Jane Oliaro


Thioredoxin-1 actively maintains the pseudokinase MLKL in a reduced state to suppress disulfide bond-dependent MLKL polymer formation and necroptosis
Eduardo Reynoso, Hua Liu, Lin Li, Anthony L. Yuan, She Chen and Zhigao Wang

MLKL forms disulfide bond-dependent amyloid-like polymers to induce necroptosis
Shuzhen Liu, Hua Liu, Andrea Johnston, Sarah Hanna-Addams, Eduardo Reynoso, Yougui Xiang, and Zhigao Wang

Sibiriline, a new small chemical inhibitor of receptor-interacting protein kinase 1, prevents immune-dependent hepatitis
Fabienne Le Cann, Claire Delehouzé, Sabrina Leverrier-Penna, Aveline Filliol, Arnaud Comte, Olivier Delalande, Nathalie Desban, Blandine Baratte, Isabelle Gallais, Claire Piquet-Pellorce, Florence Faurez, Marion Bonnet, Yvette Mettey, Peter Goekjian, Michel Samson, Peter Vandenabeele, Stéphane Bach, Marie-Thérèse Dimanche-Boitrel


Chemoproteomics-Enabled Covalent Ligand Screening Reveals a Thioredoxin-Caspase 3 Interaction Disruptor That Impairs Breast Cancer Pathogenicity
Kimberly E. Anderson, Milton To, James A. Olzmann and Daniel K. Nomura

Tumor-promoting function of apoptotic caspases by an amplification loop involving ROS, macrophages and JNK in Drosophila
Ernesto Pérez, Jillian L Lindblad and Andreas Bergmann

A Dual Role of Caspase-8 in Triggering and Sensing Proliferation-Associated DNA Damage, a Key Determinant of Liver Cancer Development
Yannick Boege, Mohsen Malehmir, Marc E. Healy, Kira Bettermann, Anna Lorentzen, Mihael Vucur, Akshay K. Ahuja, Friederike Böhm, Joachim C. Mertens, Yutaka Shimizu, Lukas Frick, Caroline Remouchamps, Karun Mutreja, Thilo Kähne, Devakumar Sundaravinayagam, Monika J. Wolf, Hubert Rehrauer, Christiane Koppe, Tobias Speicher, Susagna Padrissa-Altés, Renaud Maire, Jörn M. Schattenberg, Ju-Seong Jeong, Lei Liu, Stefan Zwirner, Regina Boger, Norbert Hüser, Roger J. Davis, Beat Müllhaupt, Holger Moch, Henning Schulze-Bergkamen, Pierre-Alain Clavien, Sabine Werner, Lubor Borsig, Sanjiv A. Luther, Philipp J. Jost, Ricardo Weinlich, Kristian Unger, Axel Behrens, Laura Hillert, Christopher Dillon, Michela Di Virgilio, David Wallach, Emmanuel Dejardin, Lars Zender, Michael Naumann, Henning Walczak, Douglas R. Green, Massimo Lopes, Inna Lavrik, Tom Luedde, Mathias Heikenwalder, Achim Weber

Engineering a light-activated caspase-3 for precise ablation of neurons in vivo
Ashley D. Smart, Roland A. Pache, Nathan D. Thomsen, Tanja Kortemme, Graeme W. Davis, and James A. Wells


Cross-talk between miR-471-5p and autophagy component proteins regulates LC3-associated phagocytosis (LAP) of apoptotic germ cells
Subbarayalu Panneerdoss, Suryavathi Viswanadhapalli, Nourhan Abdelfattah, Benjamin C. Onyeagucha, Santosh Timilsina, Tabrez A. Mohammad, Yidong Chen, Michael Drake, Kristiina Vuori, T. Rajendra Kumar & Manjeet K. Rao

Sterilizing immunity in the lung relies on targeting fungal apoptosis-like programmed cell death
Neta Shlezinger, Henriette Irmer, Sourabh Dhingra, Sarah R. Beattie, Robert A. Cramer, Gerhard H. Braus, Amir Sharon, Tobias M. Hohl

Germline BAP1 mutations induce a Warburg effect
Angela Bononi, Haining Yang, Carlotta Giorgi, Simone Patergnani, Laura Pellegrini, Mingming Su, Guoxiang Xie, Valentina Signorato, Sandra Pastorino, Paul Morris, Greg Sakamoto, Shafi Kuchay, Giovanni Gaudino, Harvey I Pass, Andrea Napolitano, Paolo Pinton, Wei Jia and Michele Carbone


Exploiting the pro-apoptotic function of NOXA as a therapeutic modality in cancer.
Guikema JE, Amiot M, Eldering E.

Role of apoptosis in the development of autosomal dominant polycystic kidney disease (ADPKD)
Peintner, L; Borner, C

Cancer: Linking Powerhouses to Suicidal Bags
Laia Martínez-Carreres, Anita Nasrallah, and Lluis Fajas

Phosphatidylserine Is the Signal for TAM Receptors and Their Ligands
Greg Lemke

Caspase-2: an orphan enzyme out of the shadows
J Forsberg, B Zhivotovsky and M Olsson


A role for caspase-8 and TRAIL-R2/DR5 in ER-stress-induced apoptosis
Cristina Muñoz-Pinedo and Abelardo López-Rivas

Functional precision cancer medicine—moving beyond pure genomics
Anthony Letai

MK2 balances inflammation and cell death
Andrew Oberst

Cdk5 derails Mcl-1’s neuroprotection


ApoList – August 2017

Bcl-2 family and MOMP

Mitochondrial permeabilization engages NF-κB-dependent anti-tumour activity under caspase deficiency
Evangelos Giampazolias, Barbara Zunino, Sandeep Dhayade, Florian Bock, Catherine Cloix, Kai Cao, Alba Roca, Jonathan Lopez, Gabriel Ichim, Emma Proïcs, Camila Rubio-Patiño, Loic Fort, Nader Yatim, Emma Woodham, Susana Orozco, Lucia Taraborrelli, Nieves Peltzer, Daniele Lecis, Laura Machesky, Henning Walczak, Matthew L. Albert, Simon Milling, Andrew Oberst,
Jean-Ehrland Ricci, Kevin M. Ryan, Karen Blyth & Stephen W. G. Tait

Synergistic action of the MCL-1 inhibitor S63845 with current therapies in preclinical models of triple-negative and HER2-amplified breast cancer
Delphine Merino , James R. Whittle, François Vaillant, Antonin Serrano, Jia-Nan Gong, Goknur Giner, Ana Leticia Maragno, Maïa Chanrion, Emilie Schneider, Bhupinder Pal, Xiang Li, Grant Dewson, Julius Gräsel, Kevin Liu, Najoua Lalaoui, David Segal, Marco J. Herold, David C. S. Huang, Gordon K. Smyth, Olivier Geneste, Guillaume Lessene, Jane E. Visvader, Geoffrey J. Lindeman

Systems analysis of apoptotic priming in ovarian cancer identifies vulnerabilities and predictors of drug response
Ioannis K. Zervantonakis, Claudia Iavarone, Hsing-Yu Chen, Laura M. Selfors, Sangeetha Palakurthi, Joyce F. Liu, Ronny Drapkin, Ursula Matulonis, Joel D. Leverson, Deepak Sampath, Gordon B. Mills & Joan S. Brugge

Apoptotic resistance of human skin mast cells is mediated by Mcl-1
Tarek Hazzan, Jürgen Eberle, Margitta Worm & Magda Babina

Essential role for Bim in mediating the apoptotic and antitumor activities of immunotoxins
A Antignani, D Segal, N Simon, R J Kreitman, D Huang and D J FitzGerald

HSPB1 facilitates ERK-mediated phosphorylation and degradation of BIM to attenuate endoplasmic reticulum stress-induced apoptosis
Donna Kennedy, Katarzyna Mnich, Deepu Oommen, Reka Chakravarthy, Leonardo Almeida-Souza, Michiel Krols, Svetlana Saveljeva, Karen Doyle, Sanjeev Gupta, Vincent Timmerman, Sophie Janssens, Adrienne M Gorman and Afshin Samali

The BH3-only proteins BIM and PUMA are not critical for the reticulocyte apoptosis caused by loss of the pro-survival protein BCL-XL
Alex RD Delbridge, Brandon J Aubrey, Craig Hyland, Jonathan P Bernardini, Ladina Di Rago, Jean-Marc Garnier, Guillaume Lessene, Andreas Strasser, Warren S Alexander and Stephanie Grabow

PUMA gene delivery to synoviocytes reduces inflammation and degeneration of arthritic joints
Saw-See Hong, Hubert Marotte, Guillaume Courbon, Gary S. Firestein, Pierre Boulanger & Pierre Miossec

Jiyuan Liu, Zhen Tian, Nan Zhou, Xueying Liu, Chenyi Liao, Beilei Lei, Jianing Li, Shengyong Zhang, and Hui Chen

The ovarian reserve is depleted during puberty in a hormonally driven process dependent on the pro-apoptotic protein BMF
Seng H Liew, Quynh-Nhu Nguyen, Andreas Strasser, Jock K Findlay and Karla J Hutt

Death receptors

JWA regulates TRAIL-induced apoptosis via MARCH8-mediated DR4 ubiquitination in cisplatin-resistant gastric cancer cells
Q Wang, Q Chen, L Zhu, M Chen, W Xu, S Panday, Z Wang, A Li, O D Røe, R Chen, S Wang, R Zhang and J Zhou

p75NTR antagonists attenuate photoreceptor cell loss in murine models of retinitis pigmentosa
María Platón-Corchado, Pablo F Barcelona, Sean Jmaeff, Miguel Marchena, Alberto M Hernández-Pinto, Catalina Hernández-Sánchez, H Uri Saragovi and Enrique J de la Rosa

Dual role of DR5 in death and survival signaling leads to TRAIL resistance in cancer cells
Yelyzaveta Shlyakhtina, Valeria Pavet and Hinrich Gronemeyer

Necroptosis / DAI

RIPK1-RIPK3-MLKL-dependent necrosis promotes the aging of mouse male reproductive system
Dianrong Li, Lingjun Meng, Tao Xu, Yaning Su, Xiao Liu, Zhiyuan Zhang and Xiaodong Wang

RIP3 attenuates the pancreatic damage induced by deletion of ATG7
Xiaodong Zhou, Li Xie, Leizhou Xia, Frank Bergmann, Markus W Büchler, Guido Kroemer, Thilo Hackert and Franco Fortunato

Regulation of RIPK1 activation by TAK1-mediated phosphorylation dictates apoptosis and necroptosis
Jiefei Geng, Yasushi Ito, Linyu Shi, Palak Amin, Jiachen Chu, Amanda Tomie Ouchida, Adnan Kasim Mookhtiar, Heng Zhao, Daichao Xu, Bing Shan, Ayaz Najafov, Guangping Gao, Shizuo Akira & Junying Yuan

ZBP1/DAI ubiquitination and sensing of influenza vRNPs activate programmed cell death
Sannula Kesavardhana, Teneema Kuriakose, Clifford S. Guy, Parimal Samir, R.K. Subbarao Malireddi, Ashutosh Mishra, and Thirumala-Devi Kanneganti

Sensing of viral and endogenous RNA by ZBP1/DAI induces necroptosis
Jonathan Maelfait, Layal Liverpool, Anne Bridgeman, Katherine B Ragan, Jason W Upton and Jan Rehwinkel

Caspases and IAPs

Essential roles of Caspase-3 in facilitating Myc-induced genetic instability and carcinogenesis
Ian M Cartwright, Xinjian Liu, Min Zhou, Fang Li and Chuan-Yuan Li

A mutation in keratin 18 that causes caspase-digestion resistance protects homozygous transgenic mice from hepatic apoptosis and injury
Han-Na Yoon, Sung-Yeon Yoon, Jin-Hyuck Hong, and Nam-On Ku

IAPs protect host target tissues from graft-versus-host disease in mice
Tomomi Toubai, Corinne Rossi, Katherine Oravecz-Wilson, Chen Liu, CynthiaZajac, Shin-Rong Julia Wu, Yaping Sun, Hideaki Fujiwara, Hiroya Tamaki, Daniel Peltier, Mary Riwes, Israel Henig, Stuart Brabbs, Colin S. Duckett, Shaomeng Wang, and Pavan Reddy

IHC-based subcellular quantification provides new insights into prognostic relevance of FLIP and procaspase-8 in non-small-cell lung cancer
Ryan A Hutchinson, Helen G Coleman, Kathy Gately, Vincent Young, Siobhan Nicholson et al.

Smac mimetics and oncolytic viruses synergize in driving anticancer T-cell responses through complementary mechanisms
Dae-Sun Kim, Himika Dastidar, Chunfen Zhang, Franz J. Zemp, Keith Lau, Matthias Ernst, Andrea Rakic, Saif Sikdar, Jahanara Rajwani, Victor Naumenko, Dale R. Balce, Ben W. Ewanchuk, Pankaj Taylor, Robin M. Yates, Craig Jenne, Chris Gafuik & Douglas J. Mahoney

Efferocytosis and corpse degradation

Mouse macrophages show different requirements for phosphatidylserine receptor Tim4 in efferocytosis
Yuichi Yanagihashi, Katsumori Segawa, Ryota Maeda, Yo-ichi Nabeshima, and Shigekazu Nagata

Presumptive TRP channel CED-11 promotes cell volume decrease and facilitates degradation of apoptotic cells in Caenorhabditis elegans
Kaitlin Driscoll, Gillian M. Stanfield, Rita Droste, and H. Robert Horvitz

T Cell Zone Resident Macrophages Silently Dispose of Apoptotic Cells in the Lymph Node
Myriam Baratin, Léa Simon, Audrey Jorquera, Clément Ghigo, Doulaye Dembele, Jonathan Nowak, Rebecca Gentek, Stephan Wienert, Frederick Klauschen, Bernard Malissen, Marc Dalod, Marc Bajénoff


Nrf2-Keap1 pathway promotes cell proliferation and diminishes ferroptosis
Z Fan, A-K Wirth, D Chen, C J Wruck, M Rauh, M Buchfelder and N Savaskan

The Tumor Suppressor p53 Limits Ferroptosis by Blocking DPP4 Activity
Yangchun Xie, Shan Zhu, Xinxin Song, Xiaofang Sun, Yong Fan, Jinbao Liu, Meizuo Zhong, Hua Yuan, Lin Zhang, Timothy R. Billiar, Michael T. Lotze, Herbert J. Zeh III, Rui Kang, Guido Kroemer, Daolin Tang


Cancer-associated fibroblasts induce cancer cell apoptosis that regulates invasion mode of tumours
G Itoh, S Chida, K Yanagihara, M Yashiro, N Aiba and M Tanaka

Aberrant localization of apoptosis protease activating factor-1 in lipid raft sub-domains of diffuse large B cell lymphomas
Jayshree L. Hirpara, Thomas Loh3, Siok Bian Ng4, Wee Joo Chng5 and Shazib Pervaiz

Permeability transition in human mitochondria persists in the absence of peripheral stalk subunits of ATP synthase
Jiuya He, Joe Carroll, Shujing Ding, Ian M. Fearnley, and John E. Walker

p21 maintains senescent cell viability under persistent DNA damage response by restraining JNK and caspase signaling
Reut Yosef, Noam Pilpel, Nurit Papismadov, Hilah Gal, Yossi Ovadya, Ezra Vadai, Stav Miller, Ziv Porat, Shifra Ben‐Dor, and Valery Krizhanovsky

Amyloid single-cell cytotoxicity assays by nanomotion detection
Francesco S Ruggeri, Anne-Laure Mahul-Mellier, Sandor Kasas, Hilal A Lashuel, Giovanni Longo et al.


Gasdermins: Effectors of Pyroptosis
Stephen B. Kovacs, Edward A. Miao

BCL2: A promising cancer therapeutic target
Gudapureddy Radha, Sathees C. Raghavan

Targeting BCL-2 in B-cell lymphomas
Matthew S. Davids

The Unfolded Protein Response in Immunogenic Cell Death and Cancer Immunotherapy
Nicole Rufo, Abhishek D. Garg, Patrizia Agostinis

Comments / other

In the Hunger Games, the Winner Takes Everything
Franziska Püschel, Cristina Muñoz-Pinedo

Jens C. Hamann, and Michael Overholtzer

A caspase-independent way to kill cancer cells
Brent E. Fitzwalter and Andrew Thorburn

Gut check: dead cell samples leads to tolerant examples
Thomas H Oguin, III and Jennifer Martinez

Mitochondrial permeability transition, F1FO‐ATPase and calcium: an enigmatic triangle
Salvatore Nesci

BAX Can Be Allosterically Sensitized to Promote Apoptosis

Cell scientist to watch – Ana Garcia-Saez


ApoList – July 2017

Necroptosis and RIP kinases

MLKL, the Protein that Mediates Necroptosis, Also Regulates Endosomal Trafficking and Extracellular Vesicle Generation
Seongmin Yoon, Andrew Kovalenko, Konstantin Bogdanov, David Wallach

Phosphatidylserine externalization, “necroptotic bodies” release, and phagocytosis during necroptosis
Sefi Zargarian Inbar Shlomovitz , Ziv Erlich, Aria Hourizadeh, Yifat Ofir-Birin, Ben A. Croker, Neta Regev-Rudzki, Liat Edry-Botzer, Motti Gerlic

SPATA2 regulates the activation of RIPK1 by modulating linear ubiquitination
Ran Wei, Lily Wen Xu, Jianping Liu, Yanxia Li, Pei Zhang, Bing Shan, Xiaojuan Lu, Lihui Qian, Zheming Wu, Kangyun Dong, Hong Zhu, Lifeng Pan, Junying Yuan, and Heling Pan

RIP1 kinase activity-dependent roles in embryonic development of Fadd-deficient mice
Yongbo Liu, Cunxian Fan, Yifan Zhang, Xianjun Yu, Xiaoxia Wu, Xixi Zhang, Qun Zhao, Haiwei Zhang, Qun Xie, Ming Li, Xiaoming Li, Qiurong Ding, Hao Ying, Dali Li and Haibing Zhang

Non-apoptotic cell death

Entosis Is Induced by Glucose Starvation
Jens C. Hamann, Alexandra Surcel, Ruoyao Chen, Carolyn Teragawa, John G. Albeck, Douglas N. Robinson, Michael Overholtzer

Mitosis can drive cell cannibalism through entosis
Joanne Durgan, Yun-Yu Tseng, Jens C Hamann, Marie-Charlotte Domart, Lucy Collinson, Alan Hall, Michael Overholtzer, Oliver Florey

Mitochondrial permeability transition involves dissociation of F1FO ATP synthase dimers and C‐ring conformation
Massimo Bonora, Claudia Morganti, Giampaolo Morciano, Gaia Pedriali, Magdalena Lebiedzinska‐Arciszewska, Giorgio Aquila, Carlotta Giorgi, Paola Rizzo, Gianluca Campo, Roberto Ferrari, Guido Kroemer, Mariusz R Wieckowski, Lorenzo Galluzzi, and Paolo Pinton

Ca^2+ binding to F‐ATP synthase β subunit triggers the mitochondrial permeability transition
Valentina Giorgio, Victoria Burchell, Marco Schiavone, Claudio Bassot, Giovanni Minervini, Valeria Petronilli, Francesco Argenton, Michael Forte, Silvio Tosatto, Giovanna Lippe, and Paolo Bernardi

Live cell visualization of gasdermin D-driven pyroptotic cell death
Joseph K Rathkey, Bryan L Benson, Steven M Chirieleison, Jie Yang, Tsan S Xiao, George R Dubyak, Alex Y Huang, and Derek W Abbott

Bcl-2 family

BAK α6 permits activation by BH3-only proteins and homooligomerization via the canonical hydrophobic groove
Mark Xiang Li, Iris K. L. Tan, Stephen B. Ma, Colin Hockings, Tobias Kratina, Michael A. Dengler, Amber E. Alsop, Ruth M. Kluck, and Grant Dewson

Targeting the differential addiction to anti-apoptotic BCL-2 family for cancer therapy
Akane Inoue-Yamauchi, Paul S. Jeng, Kwanghee Kim, Hui-Chen Chen, Song Han, Yogesh Tengarai Ganesan, Kota Ishizawa, Sylvia Jebiwott, Yiyu Dong, Maria C. Pietanza, Matthew D. Hellmann, Mark G. Kris, James J. Hsieh and Emily H. Cheng

Nabanita Mukherjee, Yan Lu, Adam Almeida, Karoline Lambert, Chung-Wai Shiau, Jung-Chen Su, Yuchun Luo,Mayumi Fujita, William A. Robinson, Steven E. Robinson, David A. Norris, and Yiqun G. Shellman

BCL2 expression in DLBCL: reappraisal of immunohistochemistry with new criteria for therapeutic biomarker evaluation
Naoko Tsuyama, Seiji Sakata, Satoko Baba, Yuko Mishima, Noriko Nishimura,
Kyoko Ueda, Masahiro Yokoyama, Yasuhito Terui, Kiyohiko Hatake, Masanobu Kitagawa, Naoki Ishizuka, Naoto Tomita, and Kengo Takeuchi

Caspases and IAPs

Caspase-9 has a nonapoptotic function in Xenopus embryonic primitive blood formation
Hong Thi Tran, Mathias Fransen, Dionysia Dimitrakopoulou, Griet Van Imschoot, Nicolas Willemarck, and Kris Vleminckx

XIAP Loss Triggers RIPK3- and Caspase-8-Driven IL-1β Activation and Cell Death as a Consequence of TLR-MyD88-Induced cIAP1-TRAF2 Degradation
Kate E. Lawlor, Rebecca Feltham, Monica Yabal, Stephanie A. Conos, Kaiwen W. Chen, Stephanie Ziehe, Carina Graß, Yifan Zhan, Tan A. Nguyen, Cathrine Hall, Angelina J. Vince, Simon M. Chatfield, Damian B. D’Silva, Kenneth C. Pang, Kate Schroder, John Silke, David L. Vaux, Philipp J. Jost, James E. Vince


TIR-domain-containing adapter-inducing interferon-β (TRIF) forms filamentous structures, whose pro-apoptotic signalling is terminated by autophagy
Ian E. Gentle, Kevin T. McHenry, Arnim Weber, Arlena Metz, Oliver Kretz, Dale Porter and Georg Häcker

Accumulation of autophagosomes confers cytotoxicity
Robert W. Button, Sheridan L. Roberts, Thea L. Willis, C. Oliver Hanemann, and Shouqing Luo


Apoptosis and Cancer
Anthony Letai

Dysregulation of BCL-2 Family Proteins by Leukaemia Fusion Genes
Lauren M Brown, Diane T Hanna, Seong L Khaw, and Paul G Ekert

The mitochondria–endoplasmic reticulum contact sites: a signalling platform for cell death
Julien Prudent, Heidi M McBride

Caspases in retinal ganglion cell death and axon regeneration
Chloe N Thomas, Martin Berry, Ann Logan, Richard J Blanch & Zubair Ahmed

Cell Death and Differentiation special issue on non-apoptotic roles of caspases

CDPs: caspase-dependent non-lethal cellular processes
Lior Aram, Keren Yacobi-Sharon and Eli Arama

– Metacaspases versus caspases in development and cell fate regulation
E A Minina, N S Coll, H Tuominen and P V Bozhkov
– Non-apoptotic cell death in animal development
Lena M Kutscher and Shai Shaham
– Non-apoptotic functions of caspases in myeloid cell differentiation
Stéphanie Solier, Michaela Fontenay, William Vainchenker, Nathalie Droin and Eric Solary
– Non-apoptotic functions of BCL-2 family proteins FREE
Atan Gross and Samuel G Katz
– Evolution of caspase-mediated cell death and differentiation: twins separated at birth O
Ryan A V Bell and Lynn A Megeney
– Caspase involvement in autophagy FREE
Panagiotis Tsapras and Ioannis P Nezis
– Caspases and their substrates FREE
Olivier Julien and James A Wells
– Killers creating new life: caspases drive apoptosis-induced proliferation in tissue repair and disease OPEN
Caitlin E Fogarty and Andreas Bergmann
– Viral hijacking of host caspases: an emerging category of pathogen–host interactions FREE
Patrick F Connolly and Howard O Fearnhead
– More alive than dead: non-apoptotic roles for caspases in neuronal development, plasticity and disease OPEN
Amrita Mukherjee and Darren W Williams
– Caspase-dependent non-apoptotic processes in development OPEN
Yu-ichiro Nakajima and Erina Kuranaga


Necroptosis: (Last) Message in a Bubble
Peter Vandenabeele, Franck Riquet, Benjamin Cappe

Autophagy regulates apoptosis on the level of the death-inducing signalling complex
Karin Nowikovsky, Michael Bergmann

Chemotherapy-Activated Caspase 3 Cleaves GSDME to Drive Pyroptosis


ApoList – June 2017

Non-apoptotic cell death

Complement-Related Regulates Autophagy in Neighboring Cells
Lin Lin, Frederico S.L.M. Rodrigues, Christina Kary, Alicia Contet, Mary Logan, Richard H.G. Baxter, Will Wood, Eric H. Baehrecke

Phosphorylation of p62 by AMP-activated protein kinase mediates autophagic cell death in adult hippocampal neural stem cells
Shinwon Ha, Seol-Hwa Jeong, Kyungrim Yi, Kyung Min Chung, Caroline Jeeyeon Hong, Seong Who Kim, Eun-Kyoung Kim and Seong-Woon Yu

Zika virus induces massive cytoplasmic vacuolization and paraptosis‐like death in infected cells
Blandine Monel, Alex A Compton, Timothée Bruel, Sonia Amraoui, Julien Burlaud‐Gaillard, Nicolas Roy, Florence Guivel‐Benhassine, Françoise Porrot, Pierre Génin, Laurent Meertens, Laura Sinigaglia, Nolwenn Jouvenet, Robert Weil, Nicoletta Casartelli, Caroline Demangel, Etienne Simon‐Lorière, Arnaud Moris, Philippe Roingeard, Ali Amara, and Olivier Schwartz

Necroptosis and RIPKs

Regression of apoptosis-resistant colorectal tumors by induction of necroptosis in mice
Gui-Wei He, Claudia Günther, Veronika Thonn, Yu-Qiang Yu, Eva Martini, Barbara Buchen, Markus F. Neurath, Michael Stürzl, and Christoph Becker

Sorafenib tosylate inhibits directly necrosome complex formation and protects in mouse models of inflammation and tissue injury
Sofie Martens, Manhyung Jeong, Wulf Tonnus, Friederike Feldmann, Sam Hofmans, Vera Goossens, Nozomi Takahashi, Jan Hinrich Bräsen, Eun-Woo Lee, Pieter Van der Veken, Jurgen Joossens, Koen Augustyns, Simone Fulda, Andreas Linkermann, Jaewhan Song and Peter Vandenabeele

Kinase-independent functions of RIPK1 regulate hepatocyte survival and liver carcinogenesis
Trieu-My Van, Apostolos Polykratis, Beate Katharina Straub, Vangelis Kondylis, Nikoletta Papadopoulou, Manolis Pasparakis

Death receptors

Lymphadenopathy driven by TCR-Vγ8Vδ1 T-cell expansion in FAS-related autoimmune lymphoproliferative syndrome
Stefano Vavassori, Jacob D. Galson, Johannes Trück, Anke van den Berg, Rienk Y. J. Tamminga, Aude Magerus-Chatinet, Olivier Pellé, Ulrike Camenisch Gross, Ewerton Marques Maggio, Seraina Prader, Lennart Opitz, Ursina Nüesch, Andrea Mauracher, Benjamin Volkmer, Oliver Speer, Luzia Suda, Benno Röthlisberger, Dieter Robert Zimmermann, Rouven Müller, Arjan Diepstra, Lydia Visser, Eugenia Haralambieva, Bénédicte Neven, Frédéric Rieux-Laucat and Jana Pachlopnik Schmid

TNFR2 Stimulation Promotes Mitochondrial Fusion via Stat3- and NF-kB-Dependent Activation of OPA1 Expression
Jinliang Nan, Hengxun Hu, Yong Sun, Lianlian Zhu, Yingchao Wang, Zhiwei Zhong, Jing Zhao, Na Zhang, Ya Wang, Yaping Wang, Jian Ye, Ling Zhang, Xinyang Hu, Wei Zhu, Jian’an Wang


Selective replication of oncolytic virus M1 results in a bystander killing effect that is potentiated by Smac mimetics
Jing Cai, Yuan Lin, Haipeng Zhang, Jiankai Liang, Yaqian Tan, Webster K. Cavenee, and Guangmei Yan

Ubiquitin-dependent regulation of Cdc42 by XIAP
Arun Murali, Jaeyoung Shin, Hajime Yurugi, Aswini Krishnan, Masato Akutsu, Alejandro Carpy, Boris Macek and Krishnaraj Rajalingam


Coupled Caspase and N-End Rule Ligase Activities Allow Recognition and Degradation of Pluripotency Factor LIN-28 during Non-Apoptotic Development
Benjamin P. Weaver, Yi M. Weaver, Shohei Mitani, Min Han

Caspase-8 contributes to angiogenesis and chemotherapy resistance in glioblastoma
Giulia Fianco, Maria Patrizia Mongiardi, Andrea Levi, Teresa De Luca, Marianna Desideri, Daniela Trisciuoglio, Donatella Del Bufalo, Irene Cinà, Anna Di Benedetto, Marcella Mottolese, Antonietta Gentile, Diego Centonze, Fabrizio Ferrè and Daniela Barilà

Repression of caspase-3 and RNA-binding protein HuR cleavage by cyclooxygenase-2 promotes drug resistance in oral squamous cell carcinoma
H Janakiraman, R P House, S Talwar, S M Courtney, E S Hazard, G Hardiman, S Mehrotra, P H Howe, V Gangaraju and V Palanisamy

Radiation inhibits salivary gland function by promoting STIM1 cleavage by caspase-3 and loss of SOCE through a TRPM2-dependent pathway
Xibao Liu , Baijuan Gong, Lorena Brito de Souza, Hwei Ling Ong, Krishna P. Subedi, Kwong Tai Cheng, William Swaim, Changyu Zheng, Yasuo Mori, Indu S. Ambudkar

NLRC3 protein inhibits inflammation by disrupting NALP3 inflammasome assembly via competition with the adaptor protein ASC for pro-caspase-1 binding
Elif Eren, Mesut Berber, and Nesrin Özören

RETRACTION: PRIMA-1MET induces mitochondrial apoptosis through activation of caspase-2

Bcl-2 family proteins

Epistatic mutations in PUMA BH3 drive an alternate binding mode to potently and selectively inhibit anti-apoptotic Bfl-1
Justin M Jenson, Jeremy A Ryan, Robert A Grant, Anthony Letai and Amy E Keating

Clinicopathological features and outcomes of progression of CLL on the BCL2 inhibitor venetoclax
Mary Ann Anderson, Constantine Tam, Thomas E. Lew, Surender Juneja, Manu Juneja, David Westerman, Meaghan Wall, Stephen Lade, Alexandra Gorelik, David C. S. Huang, John F. Seymour, and Andrew W. Roberts

Macrophages confer survival signals via CCR1-dependent translational MCL-1 induction in chronic lymphocytic leukemia
M H A van Attekum, S Terpstra, E Slinger, M von Lindern, P D Moerland, A Jongejan, A P Kater and E Eldering

Sheila X Soh, Fahad J Siddiqui, John C Allen, Go Woon Kim, Jae Cheol Lee, Yasushi Yatabe, Manabu Soda,Hiroyuki Mano, Ross A Soo, Tan-Min Chin, Hiromichi Ebi, Seiji Yano, Keitaro Matsuo, Xiaomin Niu, Shun Lu,Kazutoshi Isobe, Jih-Hsiang Lee, James C Yang, Mingchuan Zhao, Caicun Zhou, June-Koo Lee, Se-Hoon Lee, Ji Yun Lee, Myung-Ju Ahn, Tira J Tan, Daniel S Tan, Eng-Huat Tan, S. Tiong Ong, and Wan-Teck Lim


Macrophage function in tissue repair and remodeling requires IL-4 or IL-13 with apoptotic cells
Lidia Bosurgi , Y. Grace Cao, Mar Cabeza-Cabrerizo, Andrea Tucci, Lindsey D. Hughes, Yong Kong, Jason S. Weinstein, Paula Licona-Limon, Edward T. Schmid, Facundo Pelorosso, Nicola Gagliani, Joseph E. Craft, Richard A. Flavell, Sourav Ghosh, Carla V. Rothlin

PTEN counteracts FBXL2 to promote IP3R3- and Ca2+-mediated apoptosis limiting tumour growth
Shafi Kuchay, Carlotta Giorgi, Daniele Simoneschi, Julia Pagan, Sonia Missiroli, Anita Saraf, Laurence Florens, Michael P. Washburn, Ana Collazo-Lorduy, Mireia Castillo-Martin, Carlos Cordon-Cardo, Said M. Sebti, Paolo Pinton & Michele Pagano

BAP1 regulates IP3R3-mediated Ca2+ flux to mitochondria suppressing cell transformation
Angela Bononi, Carlotta Giorgi, Simone Patergnani, David Larson, Kaitlyn Verbruggen, Mika Tanji, Laura Pellegrini, Valentina Signorato, Federica Olivetto, Sandra Pastorino, Masaki Nasu, Andrea Napolitano, Giovanni Gaudino, Paul Morris, Greg Sakamoto, Laura K. Ferris, Alberto Danese, Andrea Raimondi, Carlo Tacchetti, Shafi Kuchay,Harvey I. Pass, El Bachir Affar, Haining Yang, Paolo Pinton & Michele Carbone

IRE1α promotes viral infection by conferring resistance to apoptosis
Susan L. Fink , Teshika R. Jayewickreme, Ryan D. Molony, Takao Iwawaki, Charles S. Landis, Brett D. Lindenbach, Akiko Iwasaki


The Untold Story of Granzymes in Oncoimmunology: Novel Opportunities with Old Acquaintances
Maykel Arias, Luis Martínez-Lostao, Llipsy Santiago, Angel Ferrandez, David J. Granville, Julián Pardo

BCL-2 family: integrating stress responses at the ER to control cell demise
Philippe Pihán, Amado Carreras-Sureda and Claudio Hetz

Overcoming chemotherapy drug resistance by targeting inhibitors of apoptosis proteins (IAPs)
Rama Rathore, Jennifer E. McCallum, Elizabeth Varghese, Ana-Maria Florea & Dietrich Büsselberg

Necroptosis in neurodegenerative diseases: a potential therapeutic target
Shuo Zhang, Mi-bo Tang, Hai-yang Luo, Chang-he Shi and Yu-ming Xu

Mitochondrial potassium channels in cell death
Vanessa Checchetto, Michele Azzolinib, Roberta Peruzzo,Paola Capitanio, Luigi Leanza

Special issue on Ubiquitin in Inflammation and Cell Death: All roads lead to ubiquitin
Mads Gyrd-Hansen

– Diverse ubiquitin linkages regulate RIP kinases-mediated inflammatory and cell death signaling
Axel Witt and Domagoj Vucic
– CYLD, A20 and OTULIN deubiquitinases in NF-κB signaling and cell death: so similar, yet so different
Marie Lork, Kelly Verhelst and Rudi Beyaert
– Initiation and execution mechanisms of necroptosis: an overview
Sasker Grootjans, Tom Vanden Berghe and Peter Vandenabeele
– The small molecule that packs a punch: ubiquitin-mediated regulation of RIPK1/FADD/caspase-8 complexes
Rebecca Feltham and John Silke

Comments – other

SPATA2: more than a missing link
Lisa Schlicher, Prisca Brauns-Schubert, Florian Schubert and Ulrich Maurer

Partners in Crime
Barbara Conradt

Wulf Tonnus, Florian Gembardt, Christian Hugo, and Andreas Linkermann

Locked and loaded for apoptosis [cytochrome c]
Kara L. Bren , Emma L. Raven

BH3-only proteins: the thorny end of the ER stress response
Jason A Glab, Marcel Doerflinger and Hamsa Puthalakath

Cell scientist to watch – Mads Gyrd-Hansen




ApoList – May 2017

Death receptors

MK2 Phosphorylates RIPK1 to Prevent TNF-Induced Cell Death
Isabel Jaco, Alessandro Annibaldi, Najoua Lalaoui, Rebecca Wilson, Tencho Tenev, Lucie Laurien Chun Kim, Kunzah Jamal, Sidonie Wicky John, Gianmaria Liccardi, Diep Chau, James M. Murphy, Gabriela Brumatti, Rebecca Feltham, Manolis Pasparakis, John Silke, Pascal Meier

CNS Macrophages Control Neurovascular Development via CD95L
Si Chen, Nathalie Tisch, Marcel Kegel, Rosario Yerbes, Robert Hermann, Hannes Hudalla, Cecilia Zuliani, Gülce Sila Gülcüler, Klara Zwadlo, Jakob von Engelhardt, Carmen Ruiz de Almodóvar, Ana Martin-Villalba

The linear ubiquitin chain assembly complex regulates TRAIL‐induced gene activation and cell death
Elodie Lafont, Chahrazade Kantari‐Mimoun, Peter Draber, Diego De Miguel, Torsten Hartwig, Matthias Reichert, Sebastian Kupka, Yutaka Shimizu, Lucia Taraborrelli, Maureen Spit, Martin R Sprick, and Henning Walczak

The long non-coding RNA HOTAIR enhances pancreatic cancer resistance to TNF-related apoptosis inducing ligand
Shan-zhong Yang, Fei Xu, Tong Zhou, Xinyang Zhao, Jay M McDonald, and Yabing Chen

DR5 and caspase-8 are dispensable in ER stress-induced apoptosis
Jason A Glab, Marcel Doerflinger, Christina Nedeva, Irvin Jose, George W Mbogo, James C Paton, Adrienne W Paton, Andrew J Kueh, Marco J Herold, David CS Huang, David Segal, Gabriella Brumatti and Hamsa Puthalakath

Necroptosis and RIPK1

When PERK inhibitors turn out to be new potent RIPK1 inhibitors: critical issues on the specificity and use of GSK2606414 and GSK2656157
Diego Rojas-Rivera, Tinneke Delvaeye, Ria Roelandt, Wim Nerinckx, Koen Augustyns, Peter Vandenabeele and Mathieu J M Bertrand

2-HG Inhibits Necroptosis by Stimulating DNMT1-Dependent Hypermethylation of the RIP3 Promoter
Zhentao Yang, Bin Jiang, Yan Wang, Hengxiao Ni, Jia Zhang, Jinmei Xia, Minggang Shi, Li-Man Hung, Jingsong Ruan, Tak Wah Mak, Qinxi Li, Jiahuai Han


Apoptosis inhibitor 5 is an endogenous inhibitor of caspase‐2
Gergely Imre, Jean Berthelet, Jan Heering, Sebastian Kehrloesser, Inga Maria Melzer, Byung Il Lee, Bernd Thiede, Volker Dötsch, and Krishnaraj Rajalingam

Caspase-2-mediated cell death is required for deleting aneuploid cells
S Dawar, Y Lim, J Puccini, M White, P Thomas, L Bouchier-Hayes, D R Green, L Dorstyn and S Kumar

Caspase-3 controls AML1-ETO–driven leukemogenesis via autophagy modulation in a ULK1-dependent manner
Na Man, Yurong Tan, Xiao-Jian Sun, Fan Liu, Guoyan Cheng, Sarah M. Greenblatt, Camilo Martinez, Daniel L. Karl, Koji Ando, Ming Sun, Dan Hou, Bingyi Chen, Mingjiang Xu, Feng-Chun Yang, Zhu Chen, Saijuan Chen, Stephen D. Nimer, and Lan Wang

Chemotherapy drugs induce pyroptosis through caspase-3 cleavage of a Gasdermin
Yupeng Wang, Wenqing Gao, Xuyan Shi, Jingjin Ding, Wang Liu, Huabin He, Kun Wang & Feng Shao


Genetic profiling of MYC and BCL2 in diffuse large B-cell lymphoma determines cell-of-origin–specific clinical impact
Daisuke Ennishi, Anja Mottok, Susana Ben-Neriah, Hennady P. Shulha, PedroFarinha, Fong Chun Chan, Barbara Meissner, Merrill Boyle, Christoffer Hother, Robert Kridel, Daniel Lai, Saeed Saberi, Ali Bashashati, Sohrab P. Shah, Ryan D. Morin, Marco A. Marra, Kerry J. Savage, Laurie H. Sehn, Christian Steidl, Joseph M. Connors, Randy D. Gascoyne, and David W. Scott

BH3-mimetics and BET-inhibitors elicit enhanced lethality in malignant glioma
Chiaki Tsuge Ishida, Elena Bianchetti, Chang Shu, Marc-Eric Halatsch, M. Andrew Westhoff, Georg Karpel-Massler and Markus D. Siegelin

Endoplasmic Reticulum Stress-induced Degradation of DNAJB12 Stimulates BOK Accumulation and Primes Cancer Cells for Apoptosis
Pattarawut Sopha, Hong Yu Ren, Diane E. Grove, and Douglas M Cyr

Anti-apoptotic proteins BCL-2, MCL-1 and A1 summate collectively to maintain survival of immune cell populations both in vitro and in vivo
Emma M Carrington, Yifan Zhan, Jamie L Brady, Jian-Guo Zhang, Robyn M Sutherland, Natasha S Anstee, Robyn L Schenk, Ingela B Vikstrom, Rebecca B Delconte, David Segal, Nicholas D Huntington, Philippe Bouillet, David M Tarlinton, David CS Huang, Andreas Strasser, Suzanne Cory, Marco J Herold and Andrew M Lew


Pathogen response-like recruitment and activation of neutrophils by sterile immunogenic dying cells drives neutrophil-mediated residual cell killing
Abhishek D Garg, Lien Vandenberk, Shentong Fang, Tekele Fasche, Sofie Van Eygen, Jan Maes, Matthias Van Woensel, Carolien Koks, Niels Vanthillo, Norbert Graf, Peter de Witte, Stefaan Van Gool, Petri Salven and Patrizia Agostinis

Modulation of macrophage antitumor potential by apoptotic lymphoma cells
Jorine J L P Voss, Catriona A Ford, Sofia Petrova, Lynsey Melville, Margaret Paterson, John D Pound, Pam Holland, Bruno Giotti, Tom C Freeman and Christopher D Gregory


Huntingtin Inclusions Trigger Cellular Quiescence, Deactivate Apoptosis, and Lead to Delayed Necrosis
Yasmin M. Ramdzan, Mikhail M. Trubetskov, Angelique R. Ormsby, Estella A. Newcombe, Xiaojing Sui, Mark J. Tobin, Marie N. Bongiovanni, Sally L. Gras, Grant Dewson, Jason M.L. Miller, Steven Finkbeiner, Nagaraj S. Moily, Jonathan Niclis, Clare L. Parish, Anthony W. Purcell, Michael J. Baker, Jacqueline A. Wilce, Saboora Waris, Diana Stojanovski, Till Böcking, Ching-Seng Ang, David B. Ascher, Gavin E. Reid, Danny M. Hatters

ALDH1A3 is epigenetically regulated during melanocyte transformation and is a target for melanoma treatment
M Pérez-Alea, K McGrail, S Sánchez-Redondo, B Ferrer, G Fournet, J Cortés, E Muñoz, J Hernandez-Losa, S Tenbaum, G Martin, R Costello,I Ceylan, V Garcia-Patos and J A Recio

Epstein-Barr virus ensures B cell survival by uniquely modulating apoptosis at early and late times after infection
Alexander M Price, Joanne Dai, Quentin Bazot, Luv Patel, Pavel A Nikitin, Reza Djavadian, Peter S Winter, Cristina A Salinas, Ashley Perkins Barry, Kris C Wood, Eric C Johannsen, Anthony Letai, Martin J Allday and Micah A Luftig


Plant life needs cell death, but does plant cell death need Cys proteases?
Daniela J. Sueldo and Renier A. L. van der Hoorn

Caspases rule the intracellular trafficking cartel
Catherine Duclos, Christine Lavoie and Jean-Bernard Denault

Immunological Reviews Special issue:
Molecular Mechanisms of Cell Death

– Caspase-8: regulating life and death
Bart Tummers, Douglas R. Green
– RIPK3 in cell death and inflammation: the good, the bad, and the ugly
Susana Orozco and Andrew Oberst
– The in vivo evidence for regulated necrosis
Wulf Tonnus and Andreas Linkermann
– The many ways tissue phagocytes respond to dying cells
J. Magarian Blander
… and many more.

Exploring the TRAILs less travelled: TRAIL in cancer biology and therapy
Silvia von Karstedt, Antonella Montinaro & Henning Walczak


TRAIL‐ and TNF‐induced signaling complexes—so similar yet so different
Harald Wajant

Old and Novel Functions of Caspase-2
M.A. Miles, T. Kitevska-Ilioski, C.J. Hawkins

Intercellular cannibalism fuels tumor growth
Ernesto Pérez and Andreas Bergmann

BAK regulates catalase release from peroxisomes
Yukio Fujiki , Non Miyata, Satoru Mukai, Kanji Okumoto & Emily H. Cheng

Caspase 2 in mitotic catastrophe: The terminator of aneuploid and tetraploid cells
Ilio Vitale, Gwenola Manic, Maria Castedo & Guido Kroemer

A Different Path for Harnessing TRAIL

Cell death: ESCRTing dying cells back to life

RNA decay: The anti-apoptotic function of ADAR1




ApoList – April 2017


ESCRT-III Acts Downstream of MLKL to Regulate Necroptotic Cell Death and Its Consequences
Yi-Nan Gong, Cliff Guy, Hannes Olauson, Jan Ulrich Becker, Mao Yang, Patrick Fitzgerald, Andreas Linkermann, Douglas R. Green

Necroptosis Execution Is Mediated by Plasma Membrane Nanopores Independent of Calcium
Uris Ros, Aida Peña-Blanco, Kay Hänggi, Ulrich Kunzendorf, Stefan Krautwald, W. Wei-Lynn Wong, Ana J. García-Sáez

RIPK3 Mediates Necroptosis during Embryonic Development and Postnatal Inflammation in Fadd-Deficient Mice
Qun Zhao, XianJun Yu, HaiWei Zhang, YongBo Liu, XiXi Zhang, XiaoXia Wu, Qun Xie, Ming Li, Hao Ying, Haibing Zhang

Bcl-2 family proteins

MYC selects against reduced BCL2A1/A1 protein expression during B cell lymphomagenesis
M Sochalska, F Schuler, J G Weiss, M Prchal-Murphy, V Sexl and A Villunger

Bone marrow microenvironment–derived signals induce Mcl-1 dependence in multiple myeloma
Vikas A. Gupta, Shannon M. Matulis, Jason E. Conage-Pough, Ajay K. Nooka, Jonathan L. Kaufman, Sagar Lonial, and Lawrence H. Boise

Structural Basis of Apoptosis Inhibition by the Fowlpox Virus Protein FPV039
Mohd Ishtiaq Anasir, Sofia Caria, Michael A Skinner and Marc Kvansakul

Essential role for Bim in mediating the apoptotic and antitumor activities of immunotoxins
A Antignani, D Segal, N Simon, R J Kreitman, D Huang and D J FitzGerald

Mcl-1 expression and JNK activation induces a threshold for apoptosis in Bcl-xL-overexpressing hematopoietic cells
Zhang, Yu; Li, Xin; Tan, Shisheng; Liu, Xinyu; Zhao, Xinyu; Yuan, Zhu; Nie, Chunlai

Zhongqiang Yao, Binhui Yang, Zhongqiu Liu, Wei Li, Qihua He, and Xingchun Peng

Death receptors

Caspase-10 Negatively Regulates Caspase-8-Mediated Cell Death, Switching the Response to CD95L in Favor of NF-κB Activation and Cell Survival
Sebastian Horn, Michelle A. Hughes, Ramon Schilling, Carsten Sticht, Tencho Tenev, Michaela Ploesser, Pascal Meier, Martin R. Sprick, Marion MacFarlane, Martin Leverkus

Genetic disruption of oncogenic Kras sensitizes lung cancer cells to Fas receptor-mediated apoptosis
Haiwei Mou, Jill Moore, Sunil K. Malonia, Yingxiang Li, Deniz M. Ozata, Soren Hough, Chun-Qing Song, Jordan L. Smith, Andrew Fischer, Zhiping Weng, Michael R. Green, and Wen Xue

Changes in membrane lipids drive increased endocytosis following Fas ligation
Mauro Degli Esposti, Paola Matarrese, Antonella Tinari, Agostina Longo, Serena Recalchi, Roya Khosravi-Far, Walter Malorni, Roberta Misasi, Tina Garofalo & Maurizio Sorice

Caspases, IAPs and FLIP

NPM1 directs PIDDosome-dependent caspase-2 activation in the nucleolus
Kiyohiro Ando, Melissa J. Parsons, Richa B. Shah, Chloé I. Charendoff, Sheré L. Paris, Peter H. Liu, Sara R. Fassio, Brittany A. Rohrman, Ruth Thompson, Andrew Oberst, Samuel Sidi, Lisa Bouchier-Hayes

NAIP-NLRC4 Inflammasomes Coordinate Intestinal Epithelial Cell Expulsion with Eicosanoid and IL-18 Release via Activation of Caspase-1 and -8
Isabella Rauch, Katherine A. Deets, Daisy X. Ji, Jakob von Moltke, Jeannette L. Tenthorey, Angus Y. Lee, Naomi H. Philip, Janelle S. Ayres, Igor E. Brodsky, Karsten Gronert, Russell E. Vance

Nucleotide-binding oligomerization domain (NOD) signaling defects and cell death susceptibility cannot be uncoupled in X-linked inhibitor of apoptosis (XIAP)-driven inflammatory disease
Steven M. Chirieleison, Rebecca A. Marsh, Prathna Kumar, Joseph K. Rathkey, George R. Dubyak, and Derek W. Abbott

Targeting CASP8 and FADD-like apoptosis regulator ameliorates nonalcoholic steatohepatitis in mice and nonhuman primates
Pi-Xiao Wang,Yan-Xiao Ji,Xiao-Jing Zhang,Ling-Ping Zhao,Zhen-Zhen Yan,Peng Zhang,Li-Jun Shen,Xia Yang,Jing Fang,Song Tian,Xue-Yong Zhu,Jun Gong,Xin Zhang,Qiao-Fang Wei,Yong Wang,Jing Li,Lu Wan,Qingguo Xie,Zhi-Gang She,Zhihua Wang,Zan Huang& Hongliang Li


Pyroptosis and Apoptosis Pathways Engage in Bidirectional Crosstalk in Monocytes and Macrophages.
Taabazuing CY, Okondo MC, Bachovchin DA

Topological defects in epithelia govern cell death and extrusion
Thuan Beng Saw, Amin Doostmohammadi,Vincent Nier,Leyla Kocgozlu,Sumesh Thampi,Yusuke Toyama,Philippe Marcq,Chwee Teck Lim, Julia M. Yeomans & Benoit Ladoux


Cell death-independent activities of the death receptors CD95, TRAILR1, and TRAILR2
Daniela Siegmund, Isabell Lang, Harald Wajant

Post-translational Modification of Caspases: The Other Side of Apoptosis Regulation
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