ApoList – December 2018


Multidomain Bcl-2 family proteins

Discovery of Mcl-1-specific inhibitor AZD5991 and preclinical activity in multiple myeloma and acute myeloid leukemia – Adriana E. Tron, Matthew A. Belmonte, Ammar Adam, Brian M. Aquila, Lawrence H. Boise, Elisabetta Chiarparin, Justin Cidado, Kevin J. Embrey, Eric Gangl, Francis D. Gibbons, Gareth P. Gregory, David Hargreaves, J. Adam Hendricks, Jeffrey W. Johannes, Ricky W. Johnstone, Steven L. Kazmirski, Jason G. Kettle, Michelle L. Lamb, Shannon M. Matulis, Ajay K. Nooka, Martin J. Packer, Bo Peng, Philip B. Rawlins, Daniel W. Robbins, Alwin G. Schuller, Nancy Su, Wenzhan Yang, Qing Ye, Xiaolan Zheng, J. Paul Secrist, Edwin A. Clark, David M. Wilson, Stephen E. Fawell and Alexander W. Hird. https://www.nature.com/articles/s41467-018-07551-w

Venetoclax combined with decitabine or azacitidine in treatment-naive, elderly patients with acute myeloid leukemia – Courtney D. DiNardo, Keith Pratz, Vinod Pullarkat, Brian A. Jonas, Martha Arellano, Pamela S. Becker, Olga Frankfurt, Marina Konopleva, Andrew H. Wei, Hagop M. Kantarjian, Tu Xu, Wan-Jen Hong, Brenda Chyla, Jalaja Potluri, Daniel A. Pollyea and Anthony Letai. http://bloodjournal.org/content/133/1/7.abstract?etoc

BH3-mimetic toolkit guides the respective use of BCL2 and MCL1 BH3-mimetics in myeloma treatment – Patricia Gomez-Bougie, Sophie Maiga, Benoît Tessoulin, Jessie Bourcier, Antoine Bonnet, Manuel S. Rodriguez, Steven Le Gouill, Cyrille Touzeau, Philippe Moreau, Catherine Pellat-Deceunynck and Martine Amiot. http://bloodjournal.org/content/132/25/2656.abstract?etoc

Genetic biomarkers predict response to dual BCL-2 and MCL-1 targeting in acute myeloid leukaemia cells – Martin Grundy, Sahana Balakrishnan, Matthew Fox, Claire H. Seedhouse and  Nigel H. Russell. http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=view&path[]=26540&path[]=82570

Variable BCL2/BCL2L1 ratio in multiple myeloma with t(11;14) – Alice Cleynen, Mehmet Samur, Aurore Perrot, Laure Buisson, Sabrina Maheo, Mariateresa Fulciniti, Michel Attal, Nikhil Munshi, Hervé Avet-Loiseau and Jill Corre. http://bloodjournal.org/content/132/26/2778?etoc

Targeting BCL-xL improves the efficacy of bromodomain and extra-terminal protein inhibitors in triple-negative breast cancer by eliciting the death of senescent cells – Sylvia S. Gayle, Jennifer M. Sahni, Bryan M. Webb, Kristen L. Weber-Bonk, Melyssa S. Shively, Raffaella Spina, Eli E. Bar, Matthew K. Summers and Ruth A. Keri. http://www.jbc.org/content/early/2018/11/27/jbc.RA118.004712.abstract

HOXC6 promotes cervical cancer progression via regulation of Bcl-2 – Yongsheng Wang, Cong Wang, Na Liu, Jun Hou, Wenjing Xiao and Hui Wang. https://www.fasebj.org/doi/abs/10.1096/fj.201801099RR?ai=ts&ui=ly8&af=T

NOTCH1 Represses MCL-1 Levels in GSI-resistant T-ALL, Making them Susceptible to ABT-263 – Anahita Dastur, AHyun Choi, Carlotta Costa, Xunqin Yin, August Williams, Joseph McClanaghan, Max Greenberg, Justine Roderick, Neha U. Patel, Jessica Boisvert, Ultan McDermott, Mathew J. Garnett, Jorge Almenara, Steven Grant, Kathryn Rizzo, Jeffrey A. Engelman, Michelle Kelliher, Anthony C. Faber and Cyril H. Benes. http://clincancerres.aacrjournals.org/content/25/1/31

Targeted inhibition of PI3Kα/δ is synergistic with BCL-2 blockade in genetically defined subtypes of DLBCL – Kamil Bojarczuk, Kirsty Wienand, Jeremy A. Ryan, Linfeng Chen, Mariana Villalobos-Ortiz, Elisa Mandato, Joanna Stachura, Anthony Letai, Lee N. Lawton, Bjoern Chapuy and Margaret A. Shipp. http://bloodjournal.org/content/133/1/70.abstract?etoc

BH3-only proteins

Spatiotemporal Control of CNS Myelination by Oligodendrocyte Programmed Cell Death through the TFEB-PUMA Axis – Lu O. Sun, Sara B. Mulinyawe, Hannah Y. Collins, Adiljan Ibrahim, Qingyun Li, David J. Simon, Marc Tessier-Lavigne, Ben A. Barres. https://www.cell.com/cell/fulltext/S0092-8674(18)31400-4?dgcid=raven_jbs_etoc_email

Lymphocyte-Specific Chromatin Accessibility Pre-determines Glucocorticoid Resistance in Acute Lymphoblastic Leukemia [Bim] – Duohui Jing, Yizhou Huang, Xiaoyun Liu, Keith C.S. Sia, Julia C. Zhang, Xiaolu Tai, Meng Wang, Cara E. Toscan, Hannah McCalmont, Kathryn Evans, Chelsea Mayoh, Rebecca C. Poulos, Miriam Span, Jianqing Mi, Chao Zhang, Jason W.H. Wong, Dominik Beck, John E. Pimanda, Richard B. Lock. https://www.cell.com/cancer-cell/fulltext/S1535-6108(18)30523-3

Mouse ER+/PIK3CAH1047R breast cancers caused by exogenous estrogen are heterogeneously dependent on estrogen and undergo BIM-dependent apoptosis with BH3 and PI3K agents – Elias E. Stratikopoulos, Nicole Kiess, Matthias Szabolcs, Sarah Pegno, Cheung Kakit, Xuewei Wu, Poulikos I. Poulikakos, Pamela Cheung, Hank Schmidt and Ramon Parsons. https://www.nature.com/articles/s41388-018-0436-4?

Death receptors

Herpes simplex virus 1 ICP6 impedes TNF receptor 1-induced necrosome assembly during compartmentalization to detergent-resistant membrane vesicles – Mohammad Ali, Linda Roback and Edward S. Mocarski. http://www.jbc.org/content/early/2018/11/30/jbc.RA118.004651.abstract

Caspase-8 and FLIP

RIPK1 and Caspase-8 Ensure Chromosome Stability Independently of Their Role in Cell Death and Inflammation – Gianmaria Liccardi, Laura Ramos Garcia, Tencho Tenev, Alessandro Annibaldi, Arnaud J. Legrand, David Robertson, Rebecca Feltham, Holly Anderton, Maurice Darding, Nieves Peltzer, Marius Dannappel, Hannah Schünke, Luca L. Fava, Manuel D. Haschka, Timo Glatter, Alexey Nesvizhskii, Alexander Schmidt, Philip A. Harris, John Bertin, Peter J. Gough, Andreas Villunger, John Silke, Manolis Pasparakis, Katiuscia Bianchi, Pascal Meier. https://www.cell.com/molecular-cell/fulltext/S1097-2765(18)30980-8

Regulated proteolysis of p62/SQSTM1 enables differential control of autophagy and nutrient sensing – Julia Sanchez-Garrido, Vanessa Sancho-Shimizu and Avinash R. Shenoy. http://stke.sciencemag.org/content/11/559/eaat6903

TLR-stimulated IRAKM activates caspase-8 inflammasome in microglia and promotes neuroinflammation – Cun-Jin Zhang, Meiling Jiang, Hao Zhou, Weiwei Liu, Chenhui Wang, Zizhen Kang, Bing Han, Quanri Zhang, Xing Chen, Jianxin Xiao, Amanda Fisher, William J. Kaiser, Masanori A. Murayama, Yoichiro Iwakura, Ji Gao, Julie Carman, Ashok Dongre, George Dubyak, Derek W. Abbott, Fu-Dong Shi, Richard M. Ransohoff and Xiaoxia Li. https://www.jci.org/articles/view/121901

Induction of immunosuppressive functions and NF-κB by FLIP in monocytes – Alessandra Fiore, Stefano Ugel, Francesco De Sanctis, Sara Sandri, Giulio Fracasso, Rosalinda Trovato, Silvia Sartoris, Samantha Solito, Susanna Mandruzzato, Fulvia Vascotto, Keli L. Hippen, Giada Mondanelli, Ursula Grohmann, Geny Piro, Carmine Carbone, Davide Melisi, Rita T. Lawlor, Aldo Scarpa, Alessia Lamolinara, Manuela Iezzi, Matteo Fassan, Silvio Bicciato, Bruce R. Blazar, Ugur Sahin, Peter J. Murray and Vincenzo Bronte. https://www.nature.com/articles/s41467-018-07654-4


Single-cell analysis of pyroptosis dynamics reveals conserved GSDMD-mediated subcellular events that precede plasma membrane rupture – Nathalia M. de Vasconcelos, Nina Van Opdenbosch, Hanne Van Gorp, Eef Parthoens and Mohamed Lamkanfi. https://www.nature.com/articles/s41418-018-0106-7

Inflammation / Efferocytosis

Molecular mechanisms of biogenesis of apoptotic exosome-like vesicles and their roles as damage-associated molecular patterns – Soo Jeong Park, Jeong Mi Kim, Jihyo Kim, Jaehark Hur, Sun Park, Kyongmin Kim, Ho-Joon Shin and Yong-Joon Chwae. https://www.pnas.org/content/115/50/E11721?etoc=

Efferocytosis Fuels Requirements of Fatty Acid Oxidation and the Electron Transport Chain to Polarize Macrophages for Tissue Repair – Shuang Zhang, Samuel Weinberg, Matthew DeBerge, Anastasiia Gainullina, Matthew Schipma, Jason M. Kinchen, Issam Ben-Sahra, David R. Gius, Laurent Yvan- Charvet, Navdeep S. Chandel, Paul T. Schumacker, Edward B. Thorp. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(18)30741-1#%20

Treatment-Induced Tumor Cell Apoptosis and Secondary Necrosis Drive Tumor Progression in the Residual Tumor Microenvironment through MerTK and IDO1 – Thomas A. Werfel, David L. Elion, Bushra Rahman, Donna J. Hicks, Violeta Sanchez, Paula I. Gonzales-Ericsson, Mellissa J. Nixon, Jamaal L. James, Justin M. Balko, Peggy A. Scherle, Holly K. Koblish and Rebecca S. Cook. http://cancerres.aacrjournals.org/content/79/1/171


The SMAC mimetic LCL-161 displays antitumor activity in preclinical models of rituximab-resistant B-cell lymphoma – Kyle Runckel, Matthew J. Barth, Cory Mavis, Juan J. Gu and Francisco J. Hernandez-Ilizaliturri. http://www.bloodadvances.org/content/2/23/3516.abstract?etoc

Dimerization and auto-processing induce caspase-11 protease activation within the non-canonical inflammasome – Connie Ross, Amy H Chan, Jessica Von Pein, Dave Boucher and Kate Schroder. http://life-science-alliance.org/content/1/6/e201800237.abstract

ATP Synthase C-Subunit-Deficient Mitochondria Have a Small Cyclosporine A-Sensitive Channel, but Lack the Permeability Transition Pore – Maria A. Neginskaya, Maria E. Solesio, Elena V. Berezhnaya, Giuseppe F. Amodeo, Nelli Mnatsakanyan, Elizabeth A. Jonas, Evgeny V. Pavlov. https://www.cell.com/cell-reports/fulltext/S2211-1247(18)31963-6


BH3-Mimetic Drugs: Blazing the Trail for New Cancer Medicines – Delphine Merino, Gemma L. Kelly, Guillaume Lessene, Andrew H. Wei, Andrew W. Roberts, Andreas Strasser. https://www.cell.com/cancer-cell/fulltext/S1535-6108(18)30525-7

The Structural Basis of Necroptotic Cell Death Signaling – Emma J. Petrie, Peter E. Czabotar, James M. Murphy. https://www.cell.com/trends/biochemical-sciences/fulltext/S0968-0004(18)30229-9

Role and Regulation of Pro-survival BCL-2 Proteins in Multiple Myeloma – Anne Slomp and Victor Peperzak. https://www.frontiersin.org/articles/10.3389/fonc.2018.00533/full


Special issue on Necroinflammation



* Death and fire: the concept of necroinflammation – Andreas Linkermann

* Necroptosis in anti-viral inflammation – Himani Nailwal and Francis Ka-Ming Chan

* Ferroptosis and necroinflammation, a yet poorly explored link – Bettina Proneth and Marcus Conrad

* Programmed Necrosis and Disease:We interrupt your regular programming to bring you necroinflammation – Eui Ho Kim, Sing-Wai Wong and Jennifer Martinez

* Crashing the computer: apoptosis vs. necroptosis in neuroinflammation – Bradlee L. Heckmann, Bart Tummers and Douglas R. Green

* Necroinflammation emerges as a key regulator of hematopoiesis in health and disease – Philipp J. Jost and Ulrike Höckendorf

* Paving the way for precision medicine v2.0 in intensive care by profiling necroinflammation in biofluids – Tom Vanden Berghe and Eric Hoste

* Pyroptosis versus necroptosis: similarities, differences, and crosstalk – Daniel Frank and James E. Vince

* Comparing the effects of different cell death programs in tumor progression and immunotherapy – Michelle N. Messmer, Annelise G. Snyder and Andrew Oberst


Macrophages regulate the clearance of living cells by calreticulin – Dmitri V. Krysko, Kodi S. Ravichandran and Peter Vandenabeele. https://www.nature.com/articles/s41467-018-06807-9

Glucocorticoid Resistance in Acute Lymphoblastic Leukemia: BIM Finally – Jessie A. Brown, Adolfo Ferrando. https://www.cell.com/cancer-cell/fulltext/S1535-6108(18)30532-4

Venetoclax in AML: aiming for “just right” – Laura C. Michaelis. http://bloodjournal.org/content/133/1/3?etoc

ApoList – November 2018


Efferocytosis / Inflammation

The Mitochondrial Apoptotic Effectors BAX/BAK Activate Caspase-3 and -7 to Trigger NLRP3 Inflammasome and Caspase-8 Driven IL-1β Activation – James E. Vince, Dominic De Nardo, Wenqing Gao, Angelina J. Vince, Cathrine Hall, Kate McArthur, Daniel Simpson, Swarna Vijayaraj, Lisa M. Lindqvist, Philippe Bouillet, Mark A. Rizzacasa, Si Ming Man, John Silke, Seth L. Masters, Guillaume Lessene, David C.S. Huang, Daniel H.D. Gray, Benjamin T. Kile, Feng Shao, Kate E. Lawlor. https://www.cell.com/cell-reports/fulltext/S2211-1247(18)31725-X

BAX/BAK-Induced Apoptosis Results in Caspase-8-Dependent IL-1β Maturation in Macrophages – Dhruv Chauhan, Eva Bartok, Moritz M. Gaidt, Florian J. Bock, Jennifer Herrmann, Jens M. Seeger, Petr Broz, Roland Beckmann, Hamid Kashkar, Stephen W.G. Tait, Rolf Müller, Veit Hornung. https://www.cell.com/cell-reports/fulltext/S2211-1247(18)31691-7

Efferocytosis induces a novel SLC program to promote glucose uptake and lactate release – Sho Morioka, Justin S. A. Perry, Michael H. Raymond, Christopher B. Medina, Yunlu Zhu, Liyang Zhao, Vlad Serbulea, Suna Onengut-Gumuscu, Norbert Leitinger, Sarah Kucenas, Jeffrey C. Rathmell, Liza Makowski and Kodi S. Ravichandran. https://www.nature.com/articles/s41586-018-0735-5

Efferocytosis of apoptotic alveolar epithelial cells is sufficient to initiate lung fibrosis – Kevin K. Kim, Megan R. Dotson, Manisha Agarwal, Jibing Yang, Patrick B. Bradley, Natalia Subbotina, John J. Osterholzer and Thomas H. Sisson. https://www.nature.com/articles/s41419-018-1074-z

Pyroptosis / Gasdermin D / Gasdermin E

Caspase-8 induces cleavage of gasdermin D to elicit pyroptosis during Yersinia infection – Joseph Sarhan, Beiyun C. Liu, Hayley I. Muendlein, Peng Li, Rachael Nilson, Amy Y. Tang, Anthony Rongvaux, Stephen C. Bunnell, Feng Shao, Douglas R. Green, and Alexander Poltorak. http://www.pnas.org/content/115/46/E10888?etoc=

Pathogen blockade of TAK1 triggers caspase-8–dependent cleavage of gasdermin D and cell death – Pontus Orning, Dan Weng, Kristian Starheim, Dmitry Ratner, Zachary Best, Bettina Lee, Alexandria Brooks, Shiyu Xia, Hao Wu, Michelle A. Kelliher, Scott B. Berger, Peter J. Gough, John Bertin, Megan M. Proulx, Jon D. Goguen, Nobuhiko Kayagaki, Katherine A. Fitzgerald, Egil Lien. http://science.sciencemag.org/content/362/6418/1064

ESCRT-dependent membrane repair negatively regulates pyroptosis downstream of GSDMD activation – Sebastian Rühl, Kateryna Shkarina, Benjamin Demarco, Rosalie Heilig, José Carlos Santos, Petr Broz. http://science.sciencemag.org/content/362/6417/956

Shiga Toxin/Lipopolysaccharide Activates Caspase-4 and Gasdermin D to Trigger Mitochondrial Reactive Oxygen Species Upstream of the NLRP3 Inflammasome – Jaye M. Platnich, Hyunjae Chung, Arthur Lau, Christina F. Sandall, Adom Bondzi-Simpson, Huey-Miin Chen, Takanori Komada, Aaron C. Trotman-Grant, Jeremy R. Brandelli, Justin Chun, Paul L. Beck, Dana J. Philpott, Stephen E. Girardin, May Ho, Roger P. Johnson, Justin A. MacDonald, Glen D. Armstrong, Daniel A. Muruve. https://www.cell.com/cell-reports/fulltext/S2211-1247(18)31531-6

Molecular Targeted Therapies Elicit Concurrent Apoptotic and GSDME-Dependent Pyroptotic Tumor Cell Death – Haijiao Lu, Shengzhe Zhang, Jie Wu, Minjiang Chen, Mei-Chun Cai, Yujie Fu, Wenfeng Li, Jing Wang, Xiaojing Zhao, Zhuang Yu, Pengfei Ma and Guanglei Zhuang. http://clincancerres.aacrjournals.org/content/24/23/6066

Gasdermin E Does Not Limit Apoptotic Cell Disassembly by Promoting Early Onset of Secondary Necrosis in Jurkat T Cells and THP-1 Monocytes – Rochelle Tixeira, Bo Shi†, Michael A. F. Parkes, Amy L. Hodge, Sarah Caruso, Mark D. Hulett, Amy A. Baxter, Thanh Kha Phan and Ivan K. H. Poon. https://www.frontiersin.org/articles/10.3389/fimmu.2018.02842/full

Death receptors / FLIP

TBK1 and IKKε prevent TNF-induced cell death by RIPK1 phosphorylation – Elodie Lafont, Peter Draber, Eva Rieser, Matthias Reichert, Sebastian Kupka, Diego de Miguel, Helena Draberova, Anne von Mässenhausen, Amandeep Bhamra, Stephen Henderson, Katarzyna Wojdyla, Avigayil Chalk, Silvia Surinova, Andreas Linkermann and Henning Walczak. https://www.nature.com/articles/s41556-018-0229-6

Fas receptor induces apoptosis of synovial bone and cartilage progenitor populations and promotes bone loss in antigen-induced arthritis – Elvira Lazić Mosler, Nina Lukač, Darja Flegar, Martina Fadljević, Igor Radanović, Hrvoje Cvija, Tomislav Kelava, Sanja Ivčević, Alan Šućur, Antonio Markotić, Vedran Katavić, Ana Marušić, Danka Grčević and Nataša Kovačić. https://www.fasebj.org/doi/abs/10.1096/fj.201801426R?ai=ts&ui=ly8&af=T

Cell polarity and adherens junction formation inhibit epithelial Fas cell death receptor signaling – Laurent Gagnoux-Palacios, Hala Awina, Stéphane Audebert, Aurélie Rossin, Magali Mondin, Franck Borgese, Carlota Planas-Botey, Amel Mettouchi, Jean-Paul Borg and Anne-Odile Hueber. http://jcb.rupress.org/content/217/11/3839?etoc

Cytoplasmic FLIP(S) and nuclear FLIP(L) mediate resistance of castrate-resistant prostate cancer to apoptosis induced by IAP antagonists – Christopher McCann, Nyree Crawford, Joanna Majkut, Caitriona Holohan, Chris W. D. Armstrong, Pamela J. Maxwell, Chee Wee Ong, Melissa J. LaBonte, Simon S. McDade, David J. Waugh and Daniel B. Longley. https://www.nature.com/articles/s41419-018-1125-5


A Novel MCL1 Inhibitor Combined with Venetoclax Rescues Venetoclax-Resistant Acute Myelogenous Leukemia – Haley E. Ramsey, Melissa A. Fischer, Taekyu Lee, Agnieszka E. Gorska, Maria Pia Arrate, Londa Fuller, Kelli L. Boyd, Stephen A. Strickland, John Sensintaffar, Leah J. Hogdal, Gregory D. Ayers, Edward T. Olejniczak, Stephen W. Fesik and Michael R. Savona. http://cancerdiscovery.aacrjournals.org/content/8/12/1566

AMG 176, a Selective MCL1 Inhibitor, Is Effective in Hematologic Cancer Models Alone and in Combination with Established Therapies – Sean Caenepeel, Sean P. Brown, Brian Belmontes, Gordon Moody, Kathleen S. Keegan, Danny Chui, Douglas A. Whittington, Xin Huang, Leszek Poppe, Alan C. Cheng, Mario Cardozo, Jonathan Houze, Yunxiao Li, Brian Lucas, Nick A. Paras, Xianghong Wang, Joshua P. Taygerly, Marc Vimolratana, Manuel Zancanella, Liusheng Zhu, Elaina Cajulis, Tao Osgood, Jan Sun, Leah Damon, Regina K. Egan, Patricia Greninger, Joseph D. McClanaghan, Jianan Gong, Donia Moujalled, Giovanna Pomilio, Pedro Beltran, Cyril H. Benes, Andrew W. Roberts, David C. Huang, Andrew Wei, Jude Canon, Angela Coxon and Paul E. Hughes. http://cancerdiscovery.aacrjournals.org/content/8/12/1582

Exploiting MCL1 Dependency with Combination MEK + MCL1 Inhibitors Leads to Induction of Apoptosis and Tumor Regression in KRAS-Mutant Non–Small Cell Lung Cancer – Varuna Nangia, Faria M. Siddiqui, Sean Caenepeel, Daria Timonina, Samantha J. Bilton, Nicole Phan, Maria Gomez-Caraballo, Hannah L. Archibald, Chendi Li, Cameron Fraser, Diamanda Rigas, Kristof Vajda, Lorin A. Ferris, Michael Lanuti, Cameron D. Wright, Kevin A. Raskin, Daniel P. Cahill, John H. Shin, Colleen Keyes, Lecia V. Sequist, Zofia Piotrowska, Anna F. Farago, Christopher G. Azzoli, Justin F. Gainor, Kristopher A. Sarosiek, Sean P. Brown, Angela Coxon, Cyril H. Benes, Paul E. Hughes and Aaron N. Hata. http://cancerdiscovery.aacrjournals.org/content/8/12/1598

Increased Synthesis of MCL-1 Protein Underlies Initial Survival of EGFR-Mutant Lung Cancer to EGFR Inhibitors and Provides a Novel Drug Target – Kyung-A Song, Yasuyuki Hosono, Crystal Turner, Sheeba Jacob, Timothy L. Lochmann, Yoshiko Murakami, Neha U. Patel, Jungoh Ham, Bin Hu, Krista M. Powell, Colin M. Coon, Brad E. Windle, Yuko Oya, Jennifer E. Koblinski, Hisashi Harada, Joel D. Leverson, Andrew J. Souers, Aaron N. Hata, Sosipatros Boikos, Yasushi Yatabe, Hiromichi Ebi and Anthony C. Faber. http://clincancerres.aacrjournals.org/content/24/22/5658

Survival of midbrain dopamine neurons depends on the Bcl2 factor Mcl1 – Edward J. Robinson, Sebastian P. Aguiar, Willemieke M. Kouwenhoven, Dorinde S. Starmans, Lars von Oerthel et al. https://www.nature.com/articles/s41420-018-0125-7

Other Bcl-2 family proteins

VDAC2 enables BAX to mediate apoptosis and limit tumor development – Hui San Chin, Mark X. Li, Iris K. L. Tan, Robert L. Ninnis, Boris Reljic, Kristen Scicluna, Laura F. Dagley, Jarrod J. Sandow, Gemma L. Kelly, Andre L. Samson, Stephane Chappaz, Seong L. Khaw, Catherine Chang, Andrew Morokoff, Kerstin Brinkmann, Andrew Webb, Colin Hockings, Cathrine M. Hall, Andrew J. Kueh, Michael T. Ryan, Ruth M. Kluck, Philippe Bouillet, Marco J. Herold, Daniel H. D. Gray, David C. S. Huang, Mark F. van Delft and Grant Dewson. https://www.nature.com/articles/s41467-018-07309-4

Mannose impairs tumour growth and enhances chemotherapy – Pablo Sierra Gonzalez, James O’Prey, Simone Cardaci, Valentin J. A. Barthet, Jun-ichi Sakamaki, Florian Beaumatin, Antonia Roseweir, David M. Gay, Gillian Mackay, Gaurav Malviya, Elżbieta Kania, Shona Ritchie, Alice D. Baudot, Barbara Zunino, Agata Mrowinska, Colin Nixon, Darren Ennis, Aoisha Hoyle, David Millan, Iain A. McNeish, Owen J. Sansom, Joanne Edwards and Kevin M. Ryan. https://www.nature.com/articles/s41586-018-0729-3

Venetoclax with azacitidine disrupts energy metabolism and targets leukemia stem cells in patients with acute myeloid leukemia – Daniel A. Pollyea, Brett M. Stevens[…], Craig T. Jordan. https://www.nature.com/articles/s41591-018-0233-1

And the companion paper:
Inhibition of Amino Acid Metabolism Selectively Targets Human Leukemia Stem Cells – Courtney L. Jones, Brett M. Stevens, Angelo D’Alessandro, Julie A. Reisz, Rachel Culp-Hill, Travis Nemkov, Shanshan Pei, Nabilah Khan, Biniam Adane, Haobin Ye, Anna Krug, Dominik Reinhold, Clayton Smith, James DeGregori, Daniel A. Pollyea, Craig T. Jordan. https://www.cell.com/cancer-cell/fulltext/S1535-6108(18)30471-9

Tamoxifen overrides autophagy inhibition in Beclin-1-deficient glioma cells and their resistance to adenovirus-mediated oncolysis via upregulation of PUMA and BAX – Natalya V. Kaverina, Zaira G. Kadagidze, Anton V. Borovjagin, Apollon I. Karseladze, Chung Kwon Kim, Maciej S. Lesniak, Jason Miska, Peng Zhang, Maria A. Baryshnikova, Ting Xiao, David Ornelles, Charles Cobbs, Andrey Khramtsov and Ilya V. Ulasov. https://www.nature.com/articles/s41388-018-0395-9

NOXA genetic amplification or pharmacologic induction primes lymphoma cells to BCL2 inhibitor-induced cell death – Yuxuan Liu, Patrizia Mondello, Tatiana Erazo, Neeta Bala Tannan, Zahra Asgari, Elisa de Stanchina, Gouri Nanjangud, Venkatraman E. Seshan, Shenqiu Wang, Hans-Guido Wendel and Anas Younes. http://www.pnas.org/content/115/47/12034?etoc=

Cytoplasmic pro-apoptotic function of the tumor suppressor p73 is mediated through a modified mode of recognition of the anti-apoptotic regulator Bcl-XL – Mi-Kyung Yoon, Bu-Yeon Kim, Ji-Young Lee, Ji-Hyang Ha, Sung Ah Kim, Dong-Hwa Lee, Min-Sung Lee, Mi-Kyung Lee, Jin Sun Choi, Jin Hwa Cho, Jeong-Hoon Kim, Sunhong Kim, Jaewhan Song, Sung Goo Park, Byoung Chul Park, Kwang-Hee Bae, Sang Un Choi and Seung-Wook Chi. http://www.jbc.org/content/early/2018/11/14/jbc.RA118.003061.abstract


Caspases maintain tissue integrity by an apoptosis-independent inhibition of cell migration and invasion – Anna Gorelick-Ashkenazi, Ron Weiss, Lena Sapozhnikov, Anat Florentin, Lama Tarayrah-Ibraheim, Dima Dweik, Keren Yacobi-Sharon and Eli Arama. https://www.nature.com/articles/s41467-018-05204-6

Identification of a novel caspase cleavage site in huntingtin that regulates mutant huntingtin clearance – Dale D. O. Martin, Mandi E. Schmidt, Yen T. Nguyen, Nikola Lazic and Michael R. Hayden. https://www.fasebj.org/doi/abs/10.1096/fj.201701510RRR?ai=ts&ui=ly8&af=T

14‐3‐3 protein masks the nuclear localization sequence of caspase‐2 – Aneta Smidova, Miroslava Alblova, Dana Kalabova, Katarina Psenakova, Michal Rosulek, Petr Herman, Tomas Obsil, Veronika Obsilova. https://febs.onlinelibrary.wiley.com/doi/10.1111/febs.14670

Tri-arginine exosite patch of caspase-6 recruits substrates for hydrolysis – Derek J MacPherson, Caityln L Mills, Mary Jo Ondrechen and Jeanne A. Hardy. http://www.jbc.org/content/early/2018/11/12/jbc.RA118.005914.abstract

p53 accumulation following cytokinesis failure in the absence of caspase-2 (letter) – Yoon Lim, Dylan De Bellis, Loretta Dorstyn and Sharad Kumar. https://www.nature.com/articles/s41418-018-0161-0

microRNA-378 promotes autophagy and inhibits apoptosis in skeletal muscle – Yan Li, Jingjing Jiang, Wei Liu, Hui Wang, Lei Zhao, Shengnan Liu, Peng Li, Shengjie Zhang, Chao Sun, Yuting Wu, Shuxian Yu, Xihua Li, Hui Zhang, Haifeng Qian, Duo Zhang, Feifan Guo, Qiwei Zhai, Qiurong Ding, Li Wang and Hao Ying. http://www.pnas.org/content/115/46/E10849?etoc=

Platelet CD36 signaling through ERK5 promotes caspase-dependent procoagulant activity and fibrin deposition in vivo – Moua Yang, Andaleb Kholmukhamedov, Marie L. Schulte, Brian C. Cooley, Na’il O. Scoggins, Jeremy P. Wood, Scott J. Cameron, Craig N. Morrell, Shawn M. Jobeand Roy L. Silverstein. http://www.bloodadvances.org/content/2/21/2848.abstract?etoc


Axonal degeneration induced by glutamate excitotoxicity is mediated by necroptosis – Diego E. Hernández, Natalia A. Salvadores, Guillermo Moya-Alvarado, Romina J. Catalán, Francisca C. Bronfman and Felipe A. Court. http://jcs.biologists.org/content/131/22/jcs214684?etoc

Soluble TNF-like weak inducer of apoptosis (TWEAK) enhances poly(I:C)-induced RIPK1-mediated necroptosis – Mohamed A. Anany, Jennifer Kreckel, Simone Füllsack, Alevtina Rosenthal, Christoph Otto, Daniela Siegmund and Harald Wajant. https://www.nature.com/articles/s41419-018-1137-1

hsa-miR-500a-3P alleviates kidney injury by targeting MLKL-mediated necroptosis in renal epithelial cells – Ling Jiang, Xue-Qi Liu, Qiuying Ma, Qin Yang, Li Gao, Hai-Di Li, Jia-Nan Wang, Biao Wei, Jiagen Wen, Jun Li, Yong-Gui Wu and Xiao-Ming Meng. https://www.fasebj.org/doi/abs/10.1096/fj.201801711R?ai=ts&ui=ly8&af=T


The Proton-Coupled Monocarboxylate Transporter Hermes Is Necessary for Autophagy during Cell Death – Panagiotis D. Velentzas, Lejie Zhang, Gautam Das, Tsun-Kai Chang, Charles Nelson, William R. Kobertz, Eric H. Baehrecke. https://www.cell.com/developmental-cell/fulltext/S1534-5807(18)30744-5

Intracellular transport is accelerated in early apoptotic cells – Bo Li, Shuo-Xing Dou, Jing-Wen Yuan, Yu-Ru Liu, Wei Li, Fangfu Ye, Peng-Ye Wang and Hui Li. http://www.pnas.org.sire.ub.edu/content/115/48/12118?etoc=

The yeast mitochondrial permeability transition is regulated by reactive oxygen species, endogenous Ca2+ and Cpr3, mediating cell death – Yoshiko Kamei, Masami Koushi, Yasunori Aoyama, Rei Asakai. https://www.sciencedirect.com/science/article/pii/S000527281830197X

microRNAs selectively protect hub cells of the germline stem cell niche from apoptosis – Marina Volin, Maayan Zohar-Fux, Oren Gonen, Lilach Porat-Kuperstein and Hila Toledano. http://jcb.rupress.org/content/217/11/3829?etoc


FLIP as a therapeutic target in cancer – Luke Humphreys, Margarita Espona‐Fiedler, Daniel B. Longley. https://febs.onlinelibrary.wiley.com/doi/10.1111/febs.14523

Counting on Death – Quantitative aspects of Bcl‐2 family regulation – Annika Hantusch, Markus Rehm, Thomas Brunner. https://febs.onlinelibrary.wiley.com/doi/10.1111/febs.14516

Cell-in-cell phenomena in cancer – Stefano Fais and Michael Overholtzer. https://www.nature.com/articles/s41568-018-0073-9

FADD at the Crossroads between Cancer and Inflammation – Sara Mouasni, Léa Tourneur. https://www.cell.com/trends/immunology/fulltext/S1471-4906(18)30189-3

Hematologic Tumor Cell Resistance to the BCL-2 Inhibitor Venetoclax: A Product of Its Microenvironment? – Joel D. Leverson and Dan Cojocari. https://www.frontiersin.org/articles/10.3389/fonc.2018.00458/full

Dependence receptors – the dark side awakens – Ana‐Maria Negulescu, Patrick Mehlen. https://febs.onlinelibrary.wiley.com/doi/10.1111/febs.14507


Unleashing Blocked Apoptosis in Cancer Cells: New MCL1 Inhibitors Find Their Groove – Brian Leber, Justin Kale and David W. Andrews. http://cancerdiscovery.aacrjournals.org/content/8/12/1511?

TBK1 and IKKε restrain cell death – Klaus Heger and Vishva M. Dixit. https://www.nature.com/articles/s41556-018-0239-4

Timed degradation of Mcl-1 controls mitotic cell death – Paul R. Clarke, Lindsey A. Allan and Agnieszka Skowyra. https://www.tandfonline.com/doi/full/10.1080/23723556.2018.1516450

Necroptosis is key to axonal degeneration after excitotoxicity. http://jcs.biologists.org/content/131/22/e2202?etoc

ApoList – October 2018

Bcl-2 family proteins

Humanized Mcl-1 mice enable accurate preclinical evaluation of MCL-1 inhibitors destined for clinical use – Margs S. Brennan, Catherine Chang, Lin Tai, Guillaume Lessene, Andreas  Strasser, Grant Dewson, Gemma L. Kelly and Marco J. Herold. http://bloodjournal.org/content/132/15/1573.abstract?etoc

Discovery of a small-molecule inhibitor of specific serine residue BAD phosphorylation – Vijay Pandey, Baocheng Wang, Chakrabhavi Dhananjaya Mohan, Ainiah Rushdiana Raquib, Shobith Rangappa, Venkatachalaiah Srinivasa, Julian E. Fuchs, Kesturu S. Girish, Tao Zhu, Andreas Bender, Lan Ma, Zhinan Yin, Basappa, Kanchugarakoppal S. Rangappa and Peter E. Lobie. http://www.pnas.org/content/115/44/E10505?etoc=

Activation of the apoptotic pathway during prolonged prometaphase blocks daughter cell proliferation – Yumi Uetake and Greenfield Sluder. https://www.molbiolcell.org/doi/10.1091/mbc.E18-01-0026?ai=s5&ui=2oy6&af=T

Ursolic acid facilitates apoptosis in rheumatoid arthritis synovial fibroblasts by inducing SP1-mediated Noxa expression and proteasomal degradation of Mcl-1 – Eugene Y. Kim, Kuladeep Sudini, Anil K. Singh, Mahamudul Haque, Douglas Leaman, Sadik Khuder and Salahuddin Ahmed. https://www.fasebj.org/doi/abs/10.1096/fj.201800425R?ai=s4&ui=ly8&af=T

Tyrosine Kinase Inhibitors Increase MCL1 Degradation and in Combination with BCLXL/BCL2 Inhibitors Drive Prostate Cancer Apoptosis – Seiji Arai, Oliver Jonas, Matthew A. Whitman, Eva Corey, Steven P. Balk and Sen Chen. http://clincancerres.aacrjournals.org/content/24/21/5458

Death receptors

CD95/Fas ligand mRNA is toxic to cells – Will Putzbach, Ashley Haluck-Kangas … Marcus E Peter. https://elifesciences.org/articles/38621

Linear ubiquitination of cFLIP induced by LUBAC contributes to TNFa-induced apoptosis – Yong Tang, Donghyun Joo, Guangna Liu, Hailin Tu, Jeffrey You, Jianping Jin, Xueqiang Zhao, Mien-Chie Hung and Xin Lin. http://www.jbc.org/content/early/2018/10/25/jbc.RA118.005449.abstract


Picomolar zinc binding modulates formation of Bcl10-nucleating assemblies of the caspase recruitment domain (CARD) of CARD9 – Michael J. Holliday, Ryan Ferrao, Gladys de Leon Boenig, Alberto Estevez, Elizabeth Helgason, Alexis Rohou, Erin C. Dueber and Wayne J. Fairbrother. http://www.jbc.org/content/293/43/16803.abstract.html

Cryo-EM structures of ASC and NLRC4 CARD filaments reveal a unified mechanism of nucleation and activation of caspase-1 – Yang Li, Tian-Min Fu, Alvin Lu, Kristen Witt, Jianbin Ruan, Chen Shen and Hao Wu. http://www.pnas.org/content/115/43/10845?etoc=


LC3-Associated Phagocytosis in Myeloid Cells Promotes Tumor Immune Tolerance – Larissa D. Cunha, Mao Yang, Robert Carter, Clifford Guy, Lacie Harris, Jeremy C. Crawford, Giovanni Quarato, Emilio Boada-Romero, Halime Kalkavan, Michael D.L. Johnson, Sivaraman Natarajan, Meghan E. Turnis, David Finkelstein, Joseph T. Opferman, Charles Gawad, Douglas R. Green. https://www.cell.com/cell/fulltext/S0092-8674(18)31122-X

Regulatory T Cells Promote Macrophage Efferocytosis during Inflammation Resolution – Jonathan D. Proto, Amanda C. Doran, Galina Gusarova, Arif Yurdagul Jr., Erdi Sozen, Manikandan Subramanian, Mohammad N. Islam, Christina C. Rymond, Jasper Du, Jaime Hook, George Kuriakose, Jahar Bhattacharya, Ira Tabas. https://www.cell.com/immunity/fulltext/S1074-7613(18)30335-2

RAB-35 and ARF-6 GTPases Mediate Engulfment and Clearance Following Linker Cell-Type Death – Lena M. Kutscher, Wolfgang Keil, Shai Shaham. https://www.cell.com/developmental-cell/fulltext/S1534-5807(18)30685-3

Apoptotic β-cells induce macrophage reprogramming under diabetic conditions – Meliza G. Ward, Ge Li and Mingming Hao. http://www.jbc.org/content/293/42/16160.abstract.html


The glutathione redox system is essential to prevent ferroptosis caused by impaired lipid metabolism in clear cell renal cell carcinoma – Heike Miess, Beatrice Dankworth, Arvin M. Gouw, Mathias Rosenfeldt, Werner Schmitz, Ming Jiang, Becky Saunders, Michael Howell, Julian Downward, Dean W. Felsher, Barrie Peck and Almut Schulze. https://www.nature.com/articles/s41388-018-0315-z

Activation of ferritinophagy is required for the RNA-binding protein ELAVL1/HuR to regulate ferroptosis in hepatic stellate cells – Zili Zhang, Zhen Yao, Ling Wang, Hai Ding, Jiangjuan Shao, Anping Chen, Feng Zhang and Shizhong Zheng. https://www.tandfonline.com/doi/full/10.1080/15548627.2018.1503146


Mixed Lineage Kinase Domain-like Protein MLKL Breaks Down Myelin following Nerve Injury – Zhengxin Ying, Chenjie Pan, Tianyu Shao, Liqing Liu, Lin Li, Dejia Guo, Sitao Zhang, Tianyi Yuan, Ran Cao, Zhaodi Jiang, She Chen, Fengchao Wang, Xiaodong Wang. https://www.cell.com/molecular-cell/fulltext/S1097-2765(18)30782-2

Global Profiling of Proteolysis from the Mitochondrial Amino Terminome during Early Intrinsic Apoptosis Prior to Caspase-3 Activation – Natalie C. Marshall, Theo Klein, Maichael Thejoe, Niklas von Krosigk, Jayachandran Kizhakkedathu, B. Brett Finlay and Christopher M. Overall. https://pubs.acs.org/doi/10.1021/acs.jproteome.8b00675#.W9q0UN6qJiJ

Siglec-7 engagement by GBS β-protein suppresses pyroptotic cell death of natural killer cells – Jerry J. Fong, Chih-Ming Tsai, Sudeshna Saha, Victor Nizet, Ajit Varki and Jack D. Bui. http://www.pnas.org/content/115/41/10410?etoc=

Subcellular Hsp70 Inhibitors Promote Cancer Cell Death via Different Mechanisms – Sang-Hyun Park, Kyung-Hwa Baek, Insu Shin, Injae Shin. https://www.sciencedirect.com/science/article/pii/S2451945618302241


Topology of active, membrane-embedded Bax in the context of a toroidal pore – Stephanie Bleicken, Tufa E. Assafa, Carolin Stegmueller, Alice Wittig, Ana J. Garcia-Saez and Enrica Bordignon. https://www.nature.com/articles/s41418-018-0184-6

Neurophagy, the phagocytosis of live neurons and synapses by glia, contributes to brain development and disease – Anna Vilalta, Guy C. Brown. https://febs.onlinelibrary.wiley.com/doi/10.1111/febs.14323

No Parkin Zone: Mitophagy without Parkin – Elodie Villa, Sandrine Marchetti, Jean-Ehrland Ricci. https://www.cell.com/trends/cell-biology/fulltext/S0962-8924(18)30125-9


MIM through MOM: the awakening of Bax and Bak pores – Katia Cosentino, Ana J García‐Sáez. http://emboj.embopress.org/content/37/17/e100340

MLKL Reveals Its Friendly Face: A Role in Nerve Regeneration – Peter Vandenabeele, Wim Declercq, Ria Roelandt, Tom Vanden Berghe. https://www.cell.com/molecular-cell/fulltext/S1097-2765(18)30885-2

Neighbourhood deaths cause a switch in cancer subtype – Eli Pikarsky. https://www.nature.com/articles/d41586-018-06217-3

Neighbourly deaths dictate fatehttps://www.nature.com/articles/s41568-018-0064-x

Annual Meeting of the International Society of Cancer Metabolism (ISCaM): Cancer Metabolism – Sofia Avnet, Nicola Baldini, Lucie Brisson, Angelo De Milito, Angela M. Otto, Silvia Pastoreková, Paolo E. Porporato, Gyorgy Szabadkai and Pierre Sonveaux. https://www.frontiersin.org/articles/10.3389/fonc.2018.00329/full

ApoList – September 2018


Caspases and cFLIP

ER Stress Drives Lipogenesis and Steatohepatitis via Caspase-2 Activation of S1P – Ju Youn Kim, Ricard Garcia-Carbonell, Shinichiro Yamachika, Peng Zhao, Debanjan Dhar, Rohit Loomba, Randal J. Kaufman, Alan R. Saltiel, Michael Karin. https://www.cell.com/cell/fulltext/S0092-8674(18)31036-5

Caspase-1 inhibition alleviates cognitive impairment and neuropathology in an Alzheimer’s disease mouse model – Joseph Flores, Anastasia Noël, Bénédicte Foveau, Jeffrey Lynham, Clotilde Lecrux & Andréa C. LeBlanc. https://www.nature.com/articles/s41467-018-06449-x

Inhibitor of apoptosis proteins (IAPs) mediate collagen type XI alpha 1-driven cisplatin resistance in ovarian cancer – Miran Rada, Sameera Nallanthighal, Jennifer Cha, Kerry Ryan, Jessica Sage, Catherine Eldred, Maria Ullo, Sandra Orsulic & Dong-Joo Cheon. https://www.nature.com/articles/s41388-018-0297-x

Hypercapnia increases airway smooth muscle contractility via caspase-7-mediated miR-133a-RhoA signaling – Masahiko Shigemura , Emilia Lecuona, Martín Angulo, Tetsuya Homma, Diego A. Rodríguez, Francisco J. Gonzalez-Gonzalez, Lynn C. Welch, Luciano Amarelle, Seok-Jo Kim, Naftali Kaminski, G. R. Scott Budinger, Julian Solway, Jacob I. Sznajder. http://stm.sciencemag.org/content/10/457/eaat1662

PIDD-dependent activation of caspase-2-mediated mitochondrial injury in E1A-induced cellular sensitivity to macrophage nitric oxide-induced apoptosis – Jay R. Radke, Iris Figueroa, John M. Routes & James L. Cook. https://www.nature.com/articles/s41420-018-0100-3

Release of c-FLIP brake selectively sensitizes human cancer cells to TLR3-mediated apoptosis – Lugain Alkurdi, François Virard, Béatrice Vanbervliet, Kathrin Weber, Florent Toscano, Marc Bonnin, Nolwenn Le Stang, Sylvie Lantuejoul, Olivier Micheau, Toufic Renno, Serge Lebecque & Yann Estornes. https://www.nature.com/articles/s41419-018-0850-0

Bcl-2 family proteins

Phosphorylation switches Bax from promoting to inhibiting apoptosis thereby increasing drug resistance – Justin Kale, Ozgur Kutuk, Glauber Costa Brito, Tallulah S Andrews, Brian Leber, Anthony Letai and David W Andrews. http://EMBOr.embopress.org/content/19/9/e45235?etoc

Topology of active, membrane-embedded Bax in the context of a toroidal pore – Stephanie Bleicken, Tufa E. Assafa, Carolin Stegmueller, Alice Wittig, Ana J. Garcia-Saez & Enrica Bordignon. https://www.nature.com/articles/s41418-018-0184-6

Atypical APC/C‐dependent degradation of Mcl‐1 provides an apoptotic timer during mitotic arrest – Lindsey A Allan, Agnieszka Skowyra, Katie I Rogers, Désirée Zeller and Paul R Clarke. http://EMBOJ.embopress.org/content/37/17/e96831?etoc

Comprehensive Safety Analysis of Venetoclax Monotherapy for Patients with Relapsed/Refractory Chronic Lymphocytic Leukemia – Matthew S. Davids, Michael Hallek, William Wierda, Andrew W. Roberts, Stephan Stilgenbauer, Jeffrey A. Jones, John F. Gerecitano, Su Young Kim, Jalaja Potluri, Todd Busman, Andrea Best, Maria E. Verdugo, Elisa Cerri, Monali Desai, Peter Hillmen and John F. Seymour. http://clincancerres.aacrjournals.org/content/24/18/4371

SNAP23 regulates BAX-dependent adipocyte programmed cell death independently of canonical macroautophagy – Daorong Feng, Dulguun Amgalan, Rajat Singh, Jianwen Wei, Jennifer Wen, Tszki Peter Wei, Timothy E. McGraw, Richard N. Kitsis, and Jeffrey E. Pessin. https://www.jci.org/articles/view/99217

BCL-2 selective inhibitor ABT-199 primes rhabdomyosarcoma cells to histone deacetylase inhibitor-induced apoptosis – Ulrike Heinicke, Tinka Haydn, Sarah Kehr, Meike Vogler & Simone Fulda. https://www.nature.com/articles/s41388-018-0212-5

Bcl-xl as the most promising Bcl-2 family member in targeted treatment of chondrosarcoma – Yvonne de Jong, David Monderer, Emeline Brandinelli, Morgane Monchanin, Brendy E. van den Akker, Jolieke G. van Oosterwijk, Jean Yves Blay, Aurélie Dutour & Judith V. M. G. Bovée. https://www.nature.com/articles/s41389-018-0084-0

Mex-3B induces apoptosis by inhibiting miR-92a access to the Bim-3’UTR – Takeaki Oda, Yusuke Yamazumi, Takatoshi Hiroko, Atsushi Kamiya, Saori Kiriya, Saki Suyama, Yumi Shiozaki-Sato & Tetsu Akiyama. https://www.nature.com/articles/s41388-018-0336-7

MEK inhibitors induce apoptosis via FoxO3a-dependent PUMA induction in colorectal cancer cells – Lin Lin, Dapeng Ding, Yanmei Jiang, Yan Li & Shijun Li. https://www.nature.com/articles/s41389-018-0078-y

Subtle Changes in the Levels of BCL-2 Proteins Cause Severe Craniofacial Abnormalities – Stephanie Grabow, Andrew J. Kueh, Francine Ke, Hannah K. Vanyai, Bilal N. Sheikh, Michael A. Dengler, William Chiang, Samantha Eccles, Ian M. Smyth, Lynelle K. Jones, Frederic J. de Sauvage, Mark Scott, Lachlan Whitehead, Anne K. Voss, Andreas Strasser. https://www.cell.com/cell-reports/fulltext/S2211-1247(18)31334-2

Misoprostol regulates Bnip3 repression and alternative splicing to control cellular calcium homeostasis during hypoxic stress – Jared T. Field, Matthew D. Martens, Wajihah Mughal, Yan Hai, Donald Chapman, Grant M. Hatch, Tammy L. Ivanco, William Diehl-Jones & Joseph W. Gordon. https://www.nature.com/articles/s41420-018-0104-z

BH3 mimetics induce apoptosis independent of DRP-1 in melanoma – Nabanita Mukherjee, Andrew Strosnider, Bay Vagher, Karoline A. Lambert, Sarah Slaven, William A. Robinson, Carol M. Amato, Kasey L. Couts, Judson G. T. Bemis, Jacqueline A. Turner, David A. Norris& Yiqun G. Shellman. https://www.nature.com/articles/s41419-018-0932-z

Sensitizing non-small cell lung cancer to BCL-xL-targeted apoptosis – Qi Shen, Jun Li, Junhua Mai, Zhe Zhang, Andrew Fisher, Xiaoyan Wu, Zhaoqi Li, Maricela R. Ramirez, Shuqing Chen & Haifa Shen. https://www.nature.com/articles/s41419-018-1040-9

Death receptors

LUBAC prevents lethal dermatitis by inhibiting cell death induced by TNF, TRAIL and CD95L – Lucia Taraborrelli, Nieves Peltzer, Antonella Montinaro, Sebastian Kupka, Eva Rieser, Torsten Hartwig, Aida Sarr, Maurice Darding, Peter Draber, Tobias L. Haas, Ayse Akarca, Teresa Marafioti, Manolis Pasparakis, John Bertin, Peter J. Gough, Philippe Bouillet, Andreas Strasser, Martin Leverkus, John Silke & Henning Walczak. https://www.nature.com/articles/s41467-018-06155-8

Delivery of a TNF-α–derived peptide by nanoparticles enhances its antitumor activity by inducing cell-cycle arrest and caspase-dependent apoptosis – Qiuxia Yan, Xueming Chen, Huizhen Gong, Pei Qiu, Xing Xiao, Shiying Dang, An Hong, and Yi Ma. https://www.fasebj.org/doi/abs/10.1096/fj.201800377R?ai=ts&ui=ly8&af=T

Platelet-RBC interaction mediated by FasL/FasR induces procoagulant activity important for thrombosis – Christoph Klatt, Irena Krüger, Saskia Zey, Kim-Jürgen Krott, Martina Spelleken, Nina Sarah Gowert, Alexander Oberhuber, Lena Pfaff, Wiebke Lückstädt, Kerstin Jurk, Martin Schaller, Hadi Al-Hasani, Jürgen Schrader, Steffen Massberg, Konstantin Stark, Hubert Schelzig, Malte Kelm, and Margitta Elvers. https://www.jci.org/articles/view/92077

Elevated A20 promotes TNF-induced and RIPK1-dependent intestinal epithelial cell death – Ricard Garcia-Carbonell, Jerry Wong, Ju Youn Kim, Lisa Abernathy Close, Brigid S. Boland, Thomas L. Wong, Philip A. Harris, Samuel B. Ho, Soumita Das, Peter B. Ernst, Roman Sasik, William J. Sandborn, John Bertin, Pete J. Gough, John T. Chang, Michelle Kelliher, David Boone, Monica Guma, and Michael Karin. http://www.pnas.org/content/115/39/E9192?etoc=

K6 linked polyubiquitylation of FADD by CHIP prevents death inducing signaling complex formation suppressing cell death – Jinho Seo, Eun-Woo Lee, Jihye Shin, Daehyeon Seong, Young Woo Nam, Manhyung Jeong, Seon-Hyeong Lee, Cheolju Lee & Jaewhan Song. https://www.nature.com/articles/s41388-018-0323-z

TNFR2 unlocks a RIPK1 kinase activity-dependent mode of proinflammatory TNFR1 signaling – Daniela Siegmund, Martin Ehrenschwender & Harald Wajant. https://www.nature.com/articles/s41419-018-0973-3

Ceramide synthase-6 confers resistance to chemotherapy by binding to CD95/Fas in T-cell acute lymphoblastic leukemia – Dattesh Verlekar, Sung-Jen Wei, Hwangeui Cho, Shengping Yang & Min H. Kang. https://www.nature.com/articles/s41419-018-0964-4

TNFα sensitizes hepatocytes to FasL-induced apoptosis by NFκB-mediated Fas upregulation – Laura Faletti, Lukas Peintner, Simon Neumann, Sandra Sandler, Thomas Grabinger, Sabine Mac Nelly, Irmgard Merfort, Chun-Hao Huang, Darjus Tschaharganeh, Tae-Won Kang, Florian Heinzmann, Luana D’Artista, Ulrich Maurer, Thomas Brunner, Scott Lowe, Lars Zender & Christoph Borner. https://www.nature.com/articles/s41419-018-0935-9

Necroptosis, RIP kinases, MLKL

Necroptosis microenvironment directs lineage commitment in liver cancer – Marco Seehawer, Florian Heinzmann, Luana D’Artista, Jule Harbig, Pierre-François Roux, Lisa Hoenicke, Hien Dang, Sabrina Klotz, Lucas Robinson, Grégory Doré, Nir Rozenblum, Tae-Won Kang, Rishabh Chawla, Thorsten Buch, Mihael Vucur, Mareike Roth, Johannes Zuber, Tom Luedde, Bence Sipos, Thomas Longerich, Mathias Heikenwälder, Xin Wei Wang, Oliver Bischof & Lars Zender. https://www.nature.com/articles/s41586-018-0519-y

TBK1 Suppresses RIPK1-Driven Apoptosis and Inflammation during Development and in Aging – Daichao Xu, Taijie Jin, Hong Zhu, Hongbo Chen, Dimitry Ofengeim, Chengyu Zou, Lauren Mifflin, Lifeng Pan, Palak Amin, Wanjin Li, Bing Shan, Masanori Gomi Naito, Huyan Meng, Ying Li, Heling Pan, Liviu Aron, Xian Adiconis, Joshua Z. Levin, Bruce A. Yankner, Junying Yuan. https://www.cell.com/cell/fulltext/S0092-8674(18)30969-3

Necroptosis mediates myofibre death in dystrophin-deficient mice – Jennifer E. Morgan, Alexandre Prola, Virginie Mariot, Veronica Pini, Jinhong Meng, Christophe Hourde, Julie Dumonceaux, Francesco Conti, Frederic Relaix, Francois-Jerôme Authier, Laurent Tiret, Francesco Muntoni & Maximilien Bencze. https://www.nature.com/articles/s41467-018-06057-9

RIPK3-MLKL-mediated necroinflammation contributes to AKI progression to CKD – Hui Chen, Yulu Fang, Jianfeng Wu, Hong Chen, Zhenhuan Zou, Xiaohong Zhang, Jing Shao & Yanfang Xu. https://www.nature.com/articles/s41419-018-0936-8

RIPK1 is a critical modulator of both tonic and TLR-responsive inflammatory and cell death pathways in human macrophage differentiation – Julian Buchrieser, Maria Jose Oliva-Martin, Michael D. Moore, Joshua C. D. Long, Sally A. Cowley, Jose Antonio Perez-Simón, William James & Jose Luis Venero. https://www.nature.com/articles/s41419-018-1053-4

BRAF and AXL oncogenes drive RIPK3 expression loss in cancer – Ayaz Najafov , Ioannis K. Zervantonakis, Adnan K. Mookhtiar, Patricia Greninger, Ryan J. March, Regina K. Egan, Hoang Son Luu, Daniel G. Stover, Ursula A. Matulonis, Cyril H. Benes, Junying Yuan. https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.2005756

The pseudokinase MLKL activates PAD4-dependent NET formation in necroptotic neutrophils – Akshay A. D’Cruz , Mary Speir, Meghan Bliss-Moreau, Sylvia Dietrich, Shu Wang, Alyce A. Chen, Mathilde Gavillet, Arshed Al-Obeidi, Kate E. Lawlor, James E. Vince, Michelle A. Kelliher, Razq Hakem, Manolis Pasparakis, David A. Williams, Maria Ericsson, Ben A. Croker. http://stke.sciencemag.org/content/11/546/eaao1716

The brace helices of MLKL mediate interdomain communication and oligomerisation to regulate cell death by necroptosis – Katherine A. Davies, Maria C. Tanzer, Michael D. W. Griffin, Yee Foong Mok, Samuel N. Young, Rui Qin, Emma J. Petrie, Peter E. Czabotar, John Silke & James M. Murphy. https://www.nature.com/articles/s41418-018-0061-3


Natural killer cells induce distinct modes of cancer cell death: Discrimination, quantification and modulation of apoptosis, necrosis and mixed forms – Christian S Backes, Kim S Friedmann, Sebastian Mang, Arne Knörck, Markus Hoth and Carsten Kummerow. http://www.jbc.org/content/early/2018/09/06/jbc.RA118.004549.abstract

DPP8/DPP9 inhibitor-induced pyroptosis for treatment of acute myeloid leukemia – Darren C. Johnson, Cornelius Y. Taabazuing, Marian C. Okondo, Ashley J. Chui, Sahana D. Rao, Fiona C. Brown, Casie Reed, Elizabeth Peguero, Elisa de Stanchina, Alex Kentsis & Daniel A. Bachovchin. https://www.nature.com/articles/s41591-018-0082-y

The small GTPase RAB-35 defines a third pathway that is required for the recognition and degradation of apoptotic cells – Ryan Haley, Ying Wang, Zheng Zhou. https://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1007558

Cell-to-Cell Heterogeneity in p38-Mediated Cross-Inhibition of JNK Causes Stochastic Cell Death – Haruko Miura, Yohei Kondo, Michiyuki Matsuda, Kazuhiro Aoki. https://www.cell.com/cell-reports/fulltext/S2211-1247(18)31274-9

Tryparedoxin peroxidase-deficiency commits trypanosomes to ferroptosis-type cell death – Marta Bogacz, R Luise Krauth-Siegel. https://elifesciences.org/articles/37503

BAP1 links metabolic regulation of ferroptosis to tumour suppression – Yilei Zhang, Jiejun Shi, Xiaoguang Liu, Li Feng, Zihua Gong, Pranavi Koppula, Kapil Sirohi, Xu Li, Yongkun Wei, Hyemin Lee, Li Zhuang, Gang Chen, Zhen-Dong Xiao, Mien-Chie Hung, Junjie Chen, Peng Huang, Wei Li & Boyi Gan. https://www.nature.com/articles/s41556-018-0178-0

Gasdermin D Restrains Type I Interferon Response to Cytosolic DNA by Disrupting Ionic Homeostasis – Ishita Banerjee, Bharat Behl, Morena Mendonca, Gaurav Shrivastava, Ashley J. Russo, Antoine Menoret, Arundhati Ghosh, Anthony T. Vella, Sivapriya Kailasan Vanaja, Saumendra N. Sarkar, Katherine A. Fitzgerald, Vijay A.K. Rathinam. https://www.cell.com/immunity/fulltext/S1074-7613(18)30326-1

Dynein links engulfment and execution of apoptosis via CED-4/Apaf1 in C. elegans – Rikke Hindsgaul Harders, Tine Hørning Morthorst, Anna Dippel Lande, Marianne Overgaard Hesselager, Ole Aalund Mandrup, Emøke Bendixen, Allan Stensballe & Anders Olsen. https://www.nature.com/articles/s41419-018-1067-y


Life, death and autophagy – Johnna Doherty & Eric H. Baehrecke. https://www.nature.com/articles/s41556-018-0201-5

Nutrient scavenging in cancer – Brendan T. Finicle, Vaishali Jayashankar & Aimee L. Edinger. https://www.nature.com/articles/s41568-018-0048-x

BCL-2 inhibition in AML: an unexpected bonus? – Marina Konopleva and Anthony Letai. http://bloodjournal.org/content/132/10/1007.abstract?etoc

Apoptosis-Inducing Factor (AIF) in Physiology and Disease: The Tale of a Repented Natural Born Killer – Bano D, Prehn JHM. https://linkinghub.elsevier.com/retrieve/pii/S2352-3964(18)30100-2

Autophagy-dependent cell death – where, how and why a cell eats itself to death – Shani Bialik, Santosh K. Dasari and Adi Kimchi. http://jcs.biologists.org/content/131/18/jcs215152?etoc

Apoptosis and necroptosis in the liver: a matter of life and death – Robert F. Schwabe & Tom Luedd. https://www.nature.com/articles/s41575-018-0065-y

The rise of apoptosis: targeting apoptosis in hematologic malignancies – Rebecca Valentin, Stephanie Grabow and Matthew S. Davids. http://bloodjournal.org/content/132/12/1248.abstract?etoc

The induction and consequences of Influenza A virus-induced cell death – Georgia K. Atkin-Smith, Mubing Duan, Weisan Chen & Ivan K. H. Poon. https://www.nature.com/articles/s41419-018-1035-6


Ion Man: GSDMD Punches Pores to Knock Out cGAS – Rebecca Feltham, James E. Vince. https://www.cell.com/immunity/fulltext/S1074-7613(18)30389-3

Tuning Apoptosis and Neuroinflammation: TBK1 Restrains RIPK1 – Haiyang Yu, Don W. Cleveland. https://www.cell.com/cell/fulltext/S0092-8674(18)31096-1

C. elegans RAB-35: Dual roles in apoptotic cell clearance – Christian E. Rocheleau. https://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1007534

Neighbourhood deaths cause a switch in cancer subtype – Eli Pikarsky. https://www.nature.com/articles/d41586-018-06217-3

Retraction: ROS and CHOP Are Critical for Dibenzylideneacetone to Sensitize Tumor Cells to TRAIL through Induction of Death Receptors and Downregulation of Cell Survival Proteinshttp://cancerres.aacrjournals.org/content/78/17/5185

Metabolic control of ferroptosis in cancer – Michael P. Murphy. https://www.nature.com/articles/s41556-018-0209-x

ApoList – August 2018

Bcl-2 family proteins and MOMP

Mitochondrial inner membrane permeabilisation enables mtDNA release during apoptosis – Joel S Riley, Giovanni Quarato, Catherine Cloix, Jonathan Lopez,Jim O’Prey, Matthew Pearson, James Chapman, Hiromi Sesaki, Leo M Carlin, João F Passos, Ann P Wheeler, Andrew Oberst, Kevin M Ryan, Stephen WG Tait. http://emboj.embopress.org/content/early/2018/07/31/embj.201899238

Systematic mapping of BCL-2 gene dependencies in cancer reveals molecular determinants of BH3 mimetic sensitivity – Ryan S. Soderquist, Lorin Crawford, Esther Liu, Min Lu, Anika Agarwal, Grace R. Anderson, Kevin H. Lin, Peter S. Winter, Merve Cakir & Kris C. Wood. https://www.nature.com/articles/s41467-018-05815-z

Exploiting selective BCL-2 family inhibitors to dissect cell survival dependencies and define improved strategies for cancer therapy – Leverson JD, Phillips DC, Mitten MJ, Boghaert ER, Diaz D, Tahir SK, Belmont LD, Nimmer P, Xiao Y, Ma XM, Lowes KN, Kovar P, Chen J, Jin S, Smith M, Xue J, Zhang H, Oleksijew A, Magoc TJ, Vaidya KS, Albert DH2, Tarrant JM, La N, Wang L, Tao ZF, Wendt MD, Sampath D, Rosenberg SH, Tse C, Huang DC, Fairbrother WJ, Elmore SW, Souers AJ. http://stm.sciencemag.org/content/7/279/279ra40.short

TRIM17 and TRIM28 antagonistically regulate the ubiquitination and anti-apoptotic activity of BCL2A1 – Loïc Lionnard, Pauline Duc, Margs S. Brennan, Andrew J. Kueh, Martin Pal, Francesca Guardia, Barbara Mojsa, Maria-Alessandra Damiano, Stéphan Mora, Iréna Lassot, Ramya Ravichandran, Claude Cochet, Abdel Aouacheria, Patrick Ryan Potts, Marco J. Herold, Solange Desagher & Jérôme Kucharczak. https://www.nature.com/articles/s41418-018-0169-5

Restoring PUMA induction overcomes KRAS-mediated resistance to anti-EGFR antibodies in colorectal cancer – Kyle Knickelbein, Jingshan Tong, Dongshi Chen, Yi-Jun Wang, Sandra Misale, Alberto Bardelli, Jian Yu & Lin Zhang. https://www.nature.com/articles/s41388-018-0289-x

Dual inhibition of BCL-XL and MCL-1 is required to induce tumour regression in lung squamous cell carcinomas sensitive to FGFR inhibition – Clare E. Weeden, Casey Ah-Cann, Aliaksei Z. Holik, Julie Pasquet, Jean-Marc Garnier, Delphine Merino, Guillaume Lessene & Marie-Liesse Asselin-Labat. https://www.nature.com/articles/s41388-018-0268-2

RORγt limits the amount of the cytokine receptor γc through the prosurvival factor Bcl-xLin developing thymocytes – Davinna L. Ligons , SuJin Hwang, Adam T. Waickman, Joo-Young Park, Megan A. Luckey, Jung-Hyun Park. http://stke.sciencemag.org/content/11/545/eaam8939

Death receptors

Confirming a critical role for death receptor 5 and caspase-8 in apoptosis induction by endoplasmic reticulum stress – Mable Lam, David A. Lawrence, Avi Ashkenazi & Peter Walter. https://www.nature.com/articles/s41418-018-0155-y

A Single-Agent Dual-Specificity Targeting of FOLR1 and DR5 as an Effective Strategy for Ovarian Cancer – Gururaj Shivange, Karol Urbanek, Piotr Przanowski, Justin S.A. Perry, James Jones, Robert Haggart, Christina Kostka, Tejal Patki, Edward Stelow, Yuliya Petrova, Danielle Llaneza, Marty Mayo, Kodi S. Ravichandran, Charles N. Landen, Sanchita Bhatnagar, Jogender Tushir-Singh. https://www.cell.com/cancer-cell/fulltext/S1535-6108(18)30310-6

Early activation of CD95 is limited and localized to the cytotoxic synapse – María Florencia Sánchez, Fabronia Murad, Gülce S. Gülcüler Balta, Ana Martin-Villalba, Ana J. García-Sáez and Dolores C. Carrer. https://febs.onlinelibrary.wiley.com/doi/abs/10.1111/febs.14518

Coordination between Two Branches of the Unfolded Protein Response Determines Apoptotic Cell Fate – Tsun-Kai Chang, David A. Lawrence, Min Lu, Jenille Tan, Jonathan M. Harnoss, Scot A. Marsters, Peter Liu, Wendy Sandoval, Scott E. Martin, Avi Ashkenazi. https://www.cell.com/molecular-cell/fulltext/S1097-2765(18)30513-6


HSP90 inhibition targets autophagy and induces a CASP9-dependent resistance mechanism in NSCLC – Jie Han, Leslie A. Goldstein, Wen Hou, Suman Chatterjee, Timothy F. Burns & Hannah Rabinowich. https://www.tandfonline.com/doi/full/10.1080/15548627.2018.1434471

Necroptosis / RIPK

Biallelic RIPK1 mutations in humans cause severe immunodeficiency, arthritis, and intestinal inflammation – Delphine Cuchet-Lourenço, Davide Eletto, Changxin Wu, Vincent Plagnol, Olivier Papapietro, James Curtis, Lourdes Ceron-Gutierrez, Chris M. Bacon, Scott Hackett, Badr Alsaleem, Mailis Maes, Miguel Gaspar, Ali Alisaac, Emma Goss, Eman AlIdrissi, Daniela Siegmund, Harald Wajant, Dinakantha Kumararatne, Mofareh S. AlZahrani, Peter D. Arkwright, Mario Abinun, Rainer Doffinger, Sergey Nejentsev. http://science.sciencemag.org/content/361/6404/810

Kinase domain dimerization drives RIPK3-dependent necroptosis – Saravanan Raju , Daniel M. Whalen, Meron Mengistu, Carter Swanson, John G. Quinn, Susan S. Taylor, Joshua D. Webster, Kim Newton, Andrey S. Shaw. http://stke.sciencemag.org/content/11/544/eaar2188

Neuroprotective Effects of DTIO, A Novel Analog of Nec-1, in Acute and Chronic Stages After Ischemic Stroke – Li W, Liu J, Chen JR, Zhu YM, Gao X, Ni Y, Lin B, Li H, Qiao SG, Wang C, Zhang HL, Ao GZ. https://www.sciencedirect.com/science/article/abs/pii/S0306452218305190

RIPK1–RIPK3–MLKL-Associated Necroptosis Drives Leishmania infantum Killing in Neutrophils – Laiana Arlego-Barbosa, Paloma Peixoto Fiuza, Letícia Jambeiro Borges, Fillipe dosAnjos Rolim, Mayara Borges Andrade, Nivea F Luz, Graziele Quintela-Carvalho, Jonilson Berlink Lima, Roque P. Almeida, Francis Kaming Chan, Marcelo Torres Bozza, Valeria M Borges, Deboraci Brito Prates. https://www.frontiersin.org/articles/10.3389/fimmu.2018.01818/full

Treatment with mRNA coding for the necroptosis mediator MLKL induces antitumor immunity directed against neo-epitopes – Lien Van Hoecke, Sandra Van Lint, Kenny Roose, Alexander Van Parys, Peter Vandenabeele, Johan Grooten, Jan Tavernier, Stefaan De Koker & Xavier Saelens. https://www.nature.com/articles/s41467-018-05979-8

Gasdermin D, pyroptosis

Chemical disruption of the pyroptotic pore-forming protein gasdermin D inhibits inflammatory cell death and sepsis [necrosulfonamide is a Gasdermin D inhibitor] – Joseph K. Rathkey, Junjie Zhao, Zhonghua Liu, Yinghua Chen, Jie Yang, Hannah C. Kondolf, Bryan L. Benson, Steven M. Chirieleison, Alex Y. Huang, George R. Dubyak, Tsan S. Xiao, Xiaoxia Li, Derek W. Abbott. http://immunology.sciencemag.org/content/3/26/eaat2738.full

Noncanonical inflammasome signaling elicits gasdermin D–dependent neutrophil extracellular traps – Kaiwen W. Chen, Mercedes Monteleone, Dave Boucher, Gabriel Sollberger, Divya Ramnath, Nicholas D. Condon, Jessica B. von Pein, Petr Broz, Matthew J. Sweet, Kate Schroder. http://immunology.sciencemag.org/content/3/26/eaar6676

Gasdermin D plays a vital role in the generation of neutrophil extracellular traps – Gabriel Sollberger, Axel Choidas, Garth Lawrence Burn, Peter Habenberger, Raffaella Di Lucrezia, Susanne Kordes, Sascha Menninger, Jan Eickhoff, Peter Nussbaumer, Bert Klebl, Renate Krüger, Alf Herzig, Arturo Zychlinsky. http://immunology.sciencemag.org/content/3/26/eaar6689

Interleukin-1β Maturation Triggers Its Relocation to the Plasma Membrane for Gasdermin-D-Dependent and -Independent Secretion – Mercedes Monteleone, Amanda C. Stanley, Kaiwen W. Chen, Darren L. Brown, Jelena S. Bezbradica, Jessica B. von Pein, Caroline L. Holley, Dave Boucher, Melanie R. Shakespear, Ronan Kapetanovic, Verena Rolfes, Matthew J. Sweet, Jennifer L. Stow, Kate Schroder. https://www.cell.com/cell-reports/fulltext/S2211-1247(18)31117-3

Other forms of cell death

AMPK-Mediated BECN1 Phosphorylation Promotes Ferroptosis by Directly Blocking System Xc – Activity – Xinxin Song, Shan Zhu, Pan Chen, Wen Hou, Qirong Wen, Jiao Liu, Yangchun Xie, Jinbao Liu, Daniel J. Klionsky, Guido Kroemer, Michael T. Lotze, Herbert J. Zeh, Rui Kang, Daolin Tang. https://www.cell.com/current-biology/fulltext/S0960-9822(18)30764-4

Programmed cell removal by calreticulin in tissue homeostasis and cancer – Mingye Feng, Kristopher D. Marjon, Fangfang Zhu, Rachel Weissman-Tsukamoto, Aaron Levett, Katie Sullivan, Kevin S. Kao, Maxim Markovic, Paul A. Bump, Hannah M. Jackson, Timothy S. Choi, Jing Chen, Allison M. Banuelos, Jie Liu, Phung Gip, Lei Cheng, Denong Wang & Irving L. Weissman. https://www.nature.com/articles/s41467-018-05211-7

Genomic instability in mutant p53 cancer cells upon entotic engulfment – Hannah L. Mackay, David Moore, Callum Hall, Nicolai J. Birkbak, Mariam Jamal-Hanjani, Saadia A. Karim, Vinaya M. Phatak, Lucia Piñon, Jennifer P. Morton, Charles Swanton, John Le Quesne & Patricia A. J. Muller. https://www.nature.com/articles/s41467-018-05368-1


Cholesterol impairs autophagy-mediated clearance of amyloid beta while promoting its secretion – Elisabet Barbero-Camps, Vicente Roca-Agujetas, Isabel Bartolessis, Cristina de Dios, Jose C. Fernández-Checa, Montserrat Marí, Albert Morales, Tobias Hartmann & Anna Colell. https://www.tandfonline.com/doi/full/10.1080/15548627.2018.1438807#metrics-content

Activation of the apoptotic pathway during prolonged prometaphase blocks daughter cell proliferation – Yumi Uetake and Greenfield Sluder. https://www.molbiolcell.org/doi/abs/10.1091/mbc.E18-01-0026

Perforin proteostasis is regulated through its C2 domain: supra-physiological cell death mediated by T431D-perforin – Amelia J. Brennan, Ruby H. P. Law, Paul J. Conroy, Tahereh Noori, Natalya Lukoyanova, Helen Saibil, Hideo Yagita, Annette Ciccone, Sandra Verschoor, James C. Whisstock, Joseph A. Trapani & Ilia Voskoboinik. https://www.nature.com/articles/s41418-018-0057-z

Reviews / comments

RIP kinases as modulators of inflammation and immunity – Sudan He & Xiaodong Wang. https://www.nature.com/articles/s41590-018-0188-x

Ripk1 and haematopoiesis: a case for LUBAC and Ripk3 – Alessandro Annibaldi & Pascal Meier. https://www.nature.com/articles/s41418-018-0135-2

Different apoptosis pathways in Leishmania parasites – Louise Basmaciyan, Nadine Azas & Magali Casanova. https://www.nature.com/articles/s41420-018-0092-z


ApoList – July 2018


Bcl-2 family proteins

Statins enhance efficacy of venetoclax in blood cancers – J. Scott Lee, Andrew Roberts, Dennis Juarez, Thanh-Trang T. Vo, Shruti Bhatt, Lee-or Herzog, Sharmila Mallya, Richard J. Bellin, Suresh K. Agarwal, Ahmed Hamed Salem, Tu Xu, Jia Jia, Lingxiao Li, John R. Hanna, Matthew S. Davids, Angela G. Fleischman, Susan O’Brien, Lloyd T. Lam, Joel D. Leverson, Anthony Letai, Jonathan H. Schatz and David A. Fruman



Intrinsic apoptosis circumvents the functional decline of circulating platelets but does not cause the storage lesion – Irina Pleines, Marion Lebois, Pradnya Gangatirkar, Amanda E. Au, Rachael M. Lane, Katya J. Henley, Maria Kauppi, Jason Corbin, Ping Cannon, Jonathan Bernardini, Imala Alwis, Kate E. Jarman, Sarah Ellis, Donald Metcalf, Shaun P. Jackson, Simone M. Schoenwaelder, Benjamin T. Kile and Emma C. Josefsson



DNA repair processes are critical mediators of p53-dependent tumor suppression – Ana Janic, Liz J. Valente, Matthew J. Wakefield, Leon Di Stefano, Liz Milla, Stephen Wilcox, Haoyu Yang, Lin Tai, Cassandra J. Vandenberg, Andrew J. Kueh, Shinsuke Mizutani, Margs S. Brennan, Robyn L. Schenk, Lisa M. Lindqvist, Anthony T. Papenfuss, Liam O’Connor, Andreas Strasser & Marco J. Herold



Phosphorylation alters Bim-mediated Mcl-1 stabilization and priming – Jason E. Conage-Pough and Lawrence H. Boise



Low cleaved caspase-7 levels indicate unfavourable outcome across all breast cancers [and low Bcl-2] – Lindner AU, Lucantoni F, Varešlija D, Resler A, Murphy BM, Gallagher WM, Hill ADK, Young LS, Prehn JHM.


Death receptors

Confirming a critical role for death receptor 5 and caspase-8 in apoptosis induction by endoplasmic reticulum stress – David Lawrence, Avi Ashkenazi & Peter Walter



Fas-L promotes the stem cell potency of adipose-derived mesenchymal cells – Inna Solodeev, Benjamin Meilik, Ilan Volovitz, Meirav Sela, Sharon Manheim, Shai Yarkoni, Dov Zipori, Eyal Gur & Nir Shani



Hypertonicity-enforced BCL-2 addiction unleashes the cytotoxic potential of death receptors – Simon Sirtl, Gertrud Knoll, Dieu Thuy Trinh, Isabell Lang, Daniela Siegmund, Stefanie Gross, Beatrice Schuler-Thurner, Patrick Neubert, Jonathan Jantsch, Harald Wajant & Martin Ehrenschwender



Phenotypic screening identifies a new oxazolone inhibitor of necroptosis and neuroinflammation – Sara R. Oliveira, Pedro A. Dionísio, Hugo Brito, Lídia Franco, Catarina A. B. Rodrigues, Rita C. Guedes, Carlos A. M. Afonso, Joana D. Amaral & Cecília M. P. Rodrigues


Caspases and IAPs

Caspase-8 Collaborates with Caspase-11 to Drive Tissue Damage and Execution of Endotoxic Shock – Pratyusha Mandal, Yanjun Feng, John D. Lyons, Scott B. Berger, Shunsuke Otani, Alexandra DeLaney, Gregory K. Tharp, Kristal Maner-Smith, Eileen M. Burd, Michelle Schaeffer, Sandra Hoffman, Carol Capriotti, Linda Roback, Cedrick B. Young, Zhe Liang, Eric A. Ortlund, Nelson C. DiPaolo, Steven Bosinger, John Bertin, Peter J. Gough, Igor E. Brodsky, Craig M. Coopersmith, Dmitry M. Shayakhmetov, Edward S. Mocarski



Dimer‐specific immunoprecipitation of active caspase‐2 identifies TRAF proteins as novel activators – Alexander C Robeson, Kelly R Lindblom, Jeffrey Wojton, Sally Kornbluth and Kenkyo Matsuura



Differential susceptibility of striatal, hippocampal and cortical neurons to Caspase-6 – Anastasia Noël, Libin Zhou, Bénédicte Foveau, P. Jesper Sjöström & Andréa C. LeBlanc



Unique BIR domain sets determine inhibitor of apoptosis protein–driven cell death and NOD2 complex signal specificity – Steven M. Chirieleison, Joseph K. Rathkey, Derek W. Abbott



XAF1 forms a positive feedback loop with IRF-1 to drive apoptotic stress response and suppress tumorigenesis – Seong-In Jeong, Jung-Wook Kim, Kyung-Phil Ko, Byung-Kyu Ryu, Min-Goo Lee



Low cleaved caspase-7 levels indicate unfavourable outcome across all breast cancers – Lindner AU, Lucantoni F, Varešlija D, Resler A, Murphy BM, Gallagher WM, Hill ADK, Young LS, Prehn JHM.


Execution phase and post-mortem

Apoptotic Cell-Derived Extracellular Vesicles Promote Malignancy of Glioblastoma Via Intercellular Transfer of Splicing Factors – Marat S. Pavlyukov, Hai Yu, Soniya Bastola, Mutsuko Minata, Victoria O. Shender, Yeri Lee, Suojun Zhang, Jia Wang, Svetlana Komarova, Jun Wang, Shinobu Yamaguchi, Heba Allah Alsheikh, Junfeng Shi, Dongquan Chen, Ahmed Mohyeldin, Sung-Hak Kim, Yong Jae Shin, Ksenia Anufrieva, Evgeniy G. Evtushenko, Nadezhda V. Antipova, Georgij P. Arapidi, Vadim Govorun, Nikolay B. Pestov, Mikhail I. Shakhparonov, L. James Lee, Do-Hyun Nam, Ichiro Nakano



Staurosporine-induced apoptotic water loss is cell- and attachment-specific – Michael A. Model, Nathan J. Mudrak, Priyanka S. Rana, Robert J. Clements



Competition for Space Is Controlled by Apoptosis-Induced Change of Local Epithelial Topology – Alice Tsuboi, Shizue Ohsawa, Daiki Umetsu, Yukari Sando, Erina Kuranaga, Tatsushi Igaki, Koichi Fujimoto



NAD+ Depletion Triggers Macrophage Necroptosis, a Cell Death Pathway Exploited by Mycobacterium tuberculosis – David Pajuelo, Norberto Gonzalez-Juarbe, Uday Tak, Jim Sun, Carlos J. Orihuela, Michael Niederweis



Necroptosis promotes autophagy-dependent upregulation of DAMP and results in immunosurveillance – Sheng-Yen Lin, Sung-Yuan Hsieh, Yi-Ting Fan, Wen-Chi Wei, Pei-Wen Hsiao, Dai-Hua Tsai, Tzong-Shoon Wu & Ning-Sun Yang



Activated platelets induce MLKL-driven neutrophil necroptosis and release of neutrophil extracellular traps in venous thrombosis – Daigo Nakazawa, Jyaysi Desai, Stefanie Steiger, Susanne Müller, Satish Kumar Devarapu,   Shrikant R. Mulay, Takamasa Iwakura & Hans-Joachim Anders



Phenotypic screening identifies a new oxazolone inhibitor of necroptosis and neuroinflammation – Sara R. Oliveira, Pedro A. Dionísio, Hugo Brito, Lídia Franco, Catarina A. B. Rodrigues, Rita C. Guedes, Carlos A. M. Afonso, Joana D. Amaral & Cecília M. P. Rodrigues



Nano-targeted induction of dual ferroptotic mechanisms eradicates high-risk neuroblastoma – Behrouz Hassannia, Bartosz Wiernicki, Irina Ingold, Feng Qu, Simon Van Herck, Yulia Y. Tyurina, Hülya Bayır, Behnaz A. Abhari, Jose Pedro Friedmann Angeli, Sze Men Choi, Eline Meul, Karen Heyninck, Ken Declerck, Chandra Sekhar Chirumamilla, Maija Lahtela-Kakkonen, Guy Van Camp, Dmitri V. Krysko, Paul G. Ekert, Simone Fulda, Bruno G. De Geest, Marcus Conrad, Valerian E. Kagan, Wim Vanden Berghe, Peter Vandenabeele, and Tom Vanden Berghe



Mechanism of membrane pore formation by human gasdermin‐D – Estefania Mulvihill, Lorenzo Sborgi, Stefania A Mari, Moritz Pfreundschuh, Sebastian Hiller and Daniel J Müller



Comment on “Sterilizing immunity in the lung relies on targeting fungal apoptosis-like programmed cell death” – Abdel Aouacheria,  Kyle W. Cunningham, J. Marie Hardwick, Zdena Palková, Ted Powers, Fedor F. Severin, Libuše Váchová



Response to Comment on “Sterilizing immunity in the lung relies on targeting fungal apoptosis-like programmed cell death” – Neta Shlezinger, Henriette Irmer, Sourabh Dhingra, Sarah R. Beattie, Robert A. Cramer, Gerhard H. Braus, Amir Sharon, Tobias M. Hohl



Programmed Cell Death in Immune Defense: Knowledge and Presumptions – David Wallach, Tae-Bong Kang



New insights into apoptosome structure and function – Loretta Dorstyn, Christopher W. Akey & Sharad Kumar



Do Fungi Undergo Apoptosis-Like Programmed Cell Death? – J. Marie Hardwick


Comments / other

Gut check: dead cell samples leads to tolerant examples – Thomas H Oguin III & Jennifer Martinez



Growing a gasdermin pore in membranes of pyroptotic cells – Jingjin Ding and Feng Shao



Q & A – Karen Vousden



Finding clues in the p53 maze: an interview with Karen Vousden



Jerry Chipuk: A powerhouse for mitochondrial biology


ApoList – June 2018

Death receptors

Regulation of a distinct activated RIPK1 intermediate bridging complex I and complex II in TNFα-mediated apoptosis
Palak Amin, Marcus Florez, Ayaz Najafov, Heling Pan, Jiefei Geng, Dimitry Ofengeim, Slawomir A. Dziedzic, Huibing Wang, Vica Jean Barrett, Yasushi Ito, Matthew J. LaVoie, and Junying Yuan

A Drosophila Tumor Suppressor Gene Prevents Tonic TNF Signaling through Receptor N-Glycosylation
Geert de Vreede, Holly A. Morrison, Alexandra M. Houser, Ryan M. Boileau, Ditte Andersen, Julien Colombani, David Bilder

TRAIL mediates and sustains constitutive NF-κB activation in LGL leukemia
Jun Yang, Francis R. LeBlanc, Shubha A. Dighe, Cait E. Hamele, Thomas L. Olson, David J. Feith and Thomas P. Loughran Jr

Monocyte chemotactic protein-induced protein-1 enhances DR5 degradation and negatively regulates DR5 activation-induced apoptosis through its deubiquitinase function
You-Take Oh, Guoqing Qian, Jiusheng Deng & Shi-Yong Sun

Dose intensification of TRAIL-inducing ONC201 inhibits metastasis and promotes intratumoral NK cell recruitment
Jessica Wagner, C. Leah Kline, Lanlan Zhou, Kerry S. Campbell, Alexander W. MacFarlane, Anthony J. Olszanski, Kathy Q. Cai, Harvey H. Hensley, Eric A. Ross, Marie D. Ralff, Andrew Zloza, Charles B. Chesson, Jenna H. Newman, Howard Kaufman, Joseph Bertino, Mark Stein, and Wafik S. El-Deiry

Matias Eliseo Melendez, Renato José Silva-Oliveira, Anna Luiza Silva Almeida Vicente, Lidia Maria Rebolho Batista Arantes, Ana Carolina de Carvalho, Alberto Luis Epstein, Rui Manuel Reis, and André Lopes Carvalho

Transmembrane TNF-alpha promotes chemoresistance in breast cancer cells
Zunyue Zhang, Guohong Lin, Yujing Yan, Xiang Li, Yibing Hu, Jing Wang, Bingjiao Yin, Yaqun Wu, Zhuoya Li & Xiang-Ping Yang

OTULIN limits cell death and inflammation by deubiquitinating LUBAC
Klaus Heger, Katherine E. Wickliffe, Ada Ndoja, Juan Zhang, Aditya Murthy, Debra L. Dugger, Allie Maltzman, Felipe de Sousa e Melo, Jeffrey Hung, Yi Zeng, Erik Verschueren, Donald S. Kirkpatrick, Domagoj Vucic, Wyne P. Lee, Merone Roose-Girma, Robert J. Newman, Søren Warming, Yi-Chun Hsiao, László G. Kőműves, Joshua D. Webster, Kim Newton & Vishva M. Dixit

Fas ligand promotes an inducible TLR-dependent model of cutaneous lupus–like inflammation
Purvi Mande, Bahar Zirak, Wei-Che Ko, Keyon Taravati, Karen L. Bride, Tia Y. Brodeur, April Deng, Karen Dresser, Zhaozhao Jiang, Rachel Ettinger, Katherine A. Fitzgerald, Michael D. Rosenblum, John E. Harris, and Ann Marshak-Rothstein

Caspases and IAPs

Caspase-8 deficiency in mouse embryos triggers chronic RIPK1-dependent activation of inflammatory genes, independently of RIPK3
Tae-Bong Kang, Ju-Seong Jeong, Seung-Hoon Yang, Andrew Kovalenko & David Wallach

Phosphorylation by protein kinase A disassembles the caspase-9 core
Banyuhay P. Serrano & Jeanne A. Hardy

A proximity-dependent biotinylation (BioID) approach flags the p62/sequestosome-1 protein as a caspase-1 substrate
Yvan Jamilloux, Brice Lagrange, Antonia Di MIcco, Emilie Bourdonnay, Angélina Provost, Rémy Tallant, Thomas Henry and Fabio Martinon

Stimulator of interferon genes (STING) provides insect antiviral immunity by promoting Dredd caspase–mediated NF-kB activation
Xiaoting Hua, Binbin Li, Liang Song, Cuimei Hu, Xianyang Li, Dandan Wang, Ying Xiong, Ping Zhao, Huawei He, Qingyou xia and Fei Wang

Phosphorylation of XIAP at threonine 180 controls its activity in Wnt signaling
Victoria H. Ng, Brian I. Hang, Leah M. Sawyer, Leif R. Neitzel, Emily E. Crispi, Kristie L. Rose, Tessa M. Popay, Alison Zhong, Laura A. Lee, William P. Tansey, Stacey Huppert and Ethan Lee

Differentiated Macrophages Acquire a Pro-Inflammatory and Cell Death-Resistant Phenotype Due to Increasing XIAP and P38-mediated inhibition of RipK1
Dikchha Rijal, Ardeshir Ariana, Andrew Wight, Kwangsin Kim, Norah A. Alturki, Zoya Aamir, Emmanuelle Ametepe, Robert G. Korneluk, Christopher Tiedje, Manoj B Menon, Matthias Gaestel, Scott McComb and Subash Sad

Anke Rauch, Annemarie Carlstedt, Claudia Emmerich, Al-Hassan M. Mustafa, Anja Göder, Shirley K. Knauer,Michael Linnebacher, Thorsten Heinzel, and Oliver H. Krämer

Bcl-2 family proteins

The ribosomal RPL10 R98S mutation drives IRES-dependent BCL-2 translation in T-ALL
Kim R. Kampen, Sergey O. Sulima, Benno Verbelen, Tiziana Girardi, Stijn Vereecke, Gianmarco Rinaldi, Jelle Verbeeck, Joyce Op de Beeck, Anne Uyttebroeck, Jules P. P. Meijerink, Anthony V. Moorman, Christine J. Harrison, Pieter Spincemaille, Jan Cools, David Cassiman, Sarah-Maria Fendt, Pieter Vermeersch & Kim De Keersmaecker

BH4 domain peptides derived from Bcl-2/Bcl-XL as novel tools against acute pancreatitis
Tim Vervliet, Julia V. Gerasimenko, Pawel E. Ferdek, Monika A. Jakubowska, Ole H. Petersen, Oleg V. Gerasimenko & Geert Bultynck

miR-339 Promotes Development of Stem Cell Leukemia/Lymphoma Syndrome via Downregulation of the BCL2L11 [Bim] and BAX Proapoptotic Genes
Tianxiang Hu, Yating Chong, Sumin Lu, Rebecca Wang, Haiyan Qin, Jeane Silva, Eiko Kitamura, Chang-Sheng Chang, LesleyAnn Hawthorn and John K. Cowell


Conformational switching of the pseudokinase domain promotes human MLKL tetramerization and cell death by necroptosis
Emma J. Petrie, Jarrod J. Sandow, Annette V. Jacobsen, Brian J. Smith, Michael D. W. Griffin, Isabelle S. Lucet, Weiwen Dai, Samuel N. Young, Maria C. Tanzer, Ahmad Wardak, Lung-Yu Liang, Angus D. Cowan, Joanne M. Hildebrand, Wilhelmus J. A. Kersten, Guillaume Lessene, John Silke, Peter E. Czabotar, Andrew I. Webb & James M. Murphy

PELI1 Selectively Targets Kinase-Active RIP3 for Ubiquitylation-Dependent Proteasomal Degradation
Seung-Won Choi, Han-Hee Park, Soyeon Kim, Jee Min Chung, Hyun-Jin Noh, Sue Kyung Kim, Hyun Kyu Song, Chang-Woo Lee, Michael J. Morgan, Ho Chul Kang, You-Sun Kim

MLKL Requires the Inositol Phosphate Code to Execute Necroptosis
Cole M. Dovey, Jonathan Diep, Bradley P. Clarke, Andrew T. Hale, Dan E. McNamara, Hongyan Guo, Nathaniel W. Brown Jr., Jennifer Yinuo Cao, Christy R. Grace, Peter J. Gough, John Bertin, Scott J. Dixon, Dorothea Fiedler, Edward S. Mocarski, William J. Kaiser, Tudor Moldoveanu, John D. York, Jan E. Carette

Mutant p53-Expressing Cells Undergo Necroptosis via Cell Competition with the Neighboring Normal Epithelial Cells
Hirotaka Watanabe, Kojiro Ishibashi, Hiroki Mano, Sho Kitamoto, Nanami Sato, Kazuya Hoshiba, Mugihiko Kato, Fumihiko Matsuzawa, Yasuto Takeuchi, Takanobu Shirai, Susumu Ishikawa, Yuka Morioka, Toshiaki Imagawa, Kazuyasu Sakaguchi, Suguru Yonezawa, Shunsuke Kon, Yasuyuki Fujita

Inhibition of Programmed Necrosis Limits Infarct Size through Altered Mitochondrial and Immune Responses in the Aged Female Rat Heart.
Garvin AM1, Jackson MA2, Korzick DH

Hyperglycemia potentiates a shift from apoptosis to RIP1-dependent necroptosis
William D. McCaig, Payal S. Patel, Sergey A. Sosunov, Nicole L. Shakerley, Tori A. Smiraglia, Miranda M. Craft, Katharine M. Walker, Matthew A. Deragon, Vadim S. Ten & Timothy J. LaRocca

Pyroptosis, ferroptosis and other -osis

Mechanism of gasdermin D recognition by inflammatory caspases and their inhibition by a gasdermin D-derived peptide inhibitor
Jie Yang, Zhonghua Liu, Chuanping Wang, Rui Yang, Joseph K. Rathkey, Otis W. Pinkard, Wuxian Shi, Yinghua Chen, George R. Dubyak, Derek W. Abbott, and Tsan Sam Xiao

GSDMD is critical for autoinflammatory pathology in a mouse model of Familial Mediterranean Fever
Apurva Kanneganti, R.K. Subbarao Malireddi, Pedro H.V. Saavedra, Lieselotte Vande Walle, Hanne Van Gorp, Hiroto Kambara, Heather Tillman, Peter Vogel, Hongbo R. Luo, Ramnik J. Xavier, Hongbo Chi and Mohamed Lamkanfi

Caspase-1 inhibition prevents glial inflammasome activation and pyroptosis in models of multiple sclerosis
Brienne A. McKenzie, Manmeet K. Mamik, Leina B. Saito, Roobina Boghozian, Maria Chiara Monaco, Eugene O. Major, Jian-Qiang Lu, William G. Branton, and Christopher Power

Increased erythrophagocytosis induces ferroptosis in red pulp macrophages in a mouse model of transfusion
Lyla A. Youssef, Abdelhadi Rebbaa, Sergey Pampou, Stuart P. Weisberg, Brent R. Stockwell, Eldad A. Hod and Steven L. Spitalnik

Neutrophils Kill Antibody-Opsonized Cancer Cells by Trogoptosis
Hanke L. Matlung, Liane Babes, Xi Wen Zhao, Michel van Houdt, Louise W. Treffers, Dieke J. van Rees, Katka Franke, Karin Schornagel, Paul Verkuijlen, Hans Janssen, Pasi Halonen, Cor Lieftink, Roderick L. Beijersbergen, Jeanette H.W. Leusen, Jaap J. Boelens, Ingrid Kuhnle, Jutte van der Werff Ten Bosch, Karl Seeger, Sergio Rutella, Daria Pagliara, Takashi Matozaki, Eiji Suzuki, Catharina Willemien Menke-van der Houven van Oordt, Robin van Bruggen, Dirk Roos, Rene A.W. van Lier, Taco W. Kuijpers, Paul Kubes, Timo K. van den Berg


Local apoptotic-like mechanisms underlie complement-mediated synaptic pruning
Balázs A. Györffy, Judit Kun, György Török, Éva Bulyáki, Zsolt Borhegyi, Péter Gulyássy, Viktor Kis, Péter Szocsics, András Micsonai, János Matkó, László Drahos, Gábor Juhász, Katalin A. Kékesi, and József Kardos


XIAP at the crossroads of cell death and inflammation
Domagoj Vucic

Unsolved mysteries: How does lipid peroxidation cause ferroptosis?
Huizhong Feng, Brent R. Stockwell

Caspases in metabolic disease and their therapeutic potential
Claire H Wilson & Sharad Kumar

Beyond Cell Death: New Functions for TNF Family Cytokines in Autoimmunity and Tumor Immunotherapy
Fei Yi, Nicholas Frazzette, Anthony C. Cruz, Christopher A. Klebanoff, Richard M. Siegel

ApoList – May 2018

Bcl-2 family proteins

Embryogenesis and Adult Life in the Absence of Intrinsic Apoptosis Effectors BAX, BAK, and BOK
Francine F.S. Ke, Hannah K. Vanyai, Angus D. Cowan, Alex R.D. Delbridge, Lachlan Whitehead, Stephanie Grabow, Peter E. Czabotar, Anne K. Voss, Andreas Strasser

Intrinsic Instability of BOK Enables Membrane Permeabilization in Apoptosis
Janet H. Zheng, Christy R. Grace, Cristina D. Guibao, Dan E. McNamara, Fabien Llambi, Yue-Ming Wang, Taosheng Chen, Tudor Moldoveanu

Analysis of neuronal phosphoproteome reveals PINK1 regulation of BAD function and cell death
Huida Wan, Bin Tang, Xun Liao, Qiufang Zeng, Zhuohua Zhang & Lujian Liao

Disruption of the beclin 1–BCL2 autophagy regulatory complex promotes longevity in mice
Álvaro F. Fernández, Salwa Sebti, Yongjie Wei, Zhongju Zou, Mingjun Shi, Kathryn L. McMillan, Congcong He, Tabitha Ting, Yang Liu, Wei-Chung Chiang, Denise K. Marciano, Gabriele G. Schiattarella, Govind Bhagat, Orson W. Moe, Ming Chang Hu & Beth Levine

Federico Lucantoni, Heiko Düssmann, Irene Llorente-Folch, and Jochen H.M. Prehn

Martin C. Pearce, John T. Gamble, Prasad R. Kopparapu, Edmond F. O’Donnell, Monica J. Mueller, Hyo Sang Jang,Julie A. Greenwood, Arnold C. Satterthwait, Roberta L. Tanguay, Xiao-Kun Zhang,  and  Siva Kumar Kolluri

Loss of PUMA protects the ovarian reserve during DNA-damaging chemotherapy and preserves fertility
Quynh-Nhu Nguyen, Nadeen Zerafa, Seng H. Liew, F. Hamish Morgan, Andreas Strasser, Clare L. Scott, Jock K. Findlay, Martha Hickey & Karla J. Hutt

Cotargeting BCL-2 and PI3K Induces BAX-Dependent Mitochondrial Apoptosis in AML Cells
Mohamed Rahmani, Jewel Nkwocha, Elisa Hawkins, Xinyan Pei, Rebecca E. Parker, Maciej Kmieciak, Joel D. Leverson, Deepak Sampath, Andrea Ferreira-Gonzalez and Steven Grant

Bcl-2 Protein Targeting by the p53/p21 Complex—Letter
Liz J. Hernandez Borrero, Rahmat Sikder, Amriti Lulla, Prashanth Gokare, Paulo R. Del Valle, Xiaobing Tian, Shengliang Zhang, Philip H. Abbosh and Wafik S. El-Deiry

Bcl-2 Protein Targeting by the p53/p21 Complex—Response
Eun Mi Kim, Jongdoo Kim and Hong-Duck Um

Death receptors and IAPs

N-glycosylation of mouse TRAIL-R restrains TRAIL-induced apoptosis
Yann Estornes, Yves Dondelinger, Kathrin Weber, Inge Bruggeman, Adam Peall, Marion MacFarlane, Serge Lebecque, Peter Vandenabeele & Mathieu J. M. Bertrand

Inhibitor of apoptosis proteins are required for effective fusion of autophagosomes with lysosomes
Sylwia Gradzka, Oliver S. Thomas, Oliver Kretz, Aladin Haimovici, Lazaros. Vasilikos, Wendy Wei-Lynn Wong, Georg Häcker & Ian E. Gentle


Caspase-3 Regulates YAP-Dependent Cell Proliferation and Organ Size
Yahav Yosefzon, Despina Soteriou, Alona Feldman, Lana Kostic, Elle Koren, Samara Brown, Roi Ankawa, Egor Sedov, Fabian Glaser, Yaron Fuchs

Plasma Membrane Localization of Apoptotic Caspases for Non-apoptotic Functions
Alla Amcheslavsky, Shiuan Wang, Caitlin E. Fogarty, Jillian L. Lindblad, Yun Fan, Andreas Bergmann

Balance between senescence and apoptosis is regulated by telomere damage–induced association between p16 and caspase-3
Shanmugam Panneer Selvam, Braden M Roth, Rose Nganga, Jisun Kim, Marion A Cooley, Kristi L. Helke, Charles D. Smith and Besim Ogretmen

Caspase-3 suppresses diethylnitrosamine-induced hepatocyte death, compensatory proliferation and hepatocarcinogenesis through inhibiting p38 activation
Na Shang, Thomas Bank, Xianzhong Ding, Peter Breslin, Jun Li, Baomin Shi & Wei Qiu

Caspase-mediated cleavage of the centrosomal proteins during apoptosis
Mi Young Seo & Kunsoo Rhee

Mutations in the P10 region of procaspase-8 lead to chemotherapy resistance in acute myeloid leukemia by impairing procaspase-8 dimerization
Ming Li, Xiao-Mo Wu, Ju Gao, Fen Yang, Cui-Lin Zhang, Kun Ke, Ying-Chao Wang, You-Shi Zheng, Jian-Feng Yao, Ying-Ying Guan, Xuan Chen, Juan Chen, Xiao-Long Liu & Xiao-Yu Yang

RIK1 / Necroptosis

The Structure of the Necrosome RIPK1-RIPK3 Core, a Human Hetero-Amyloid Signaling Complex
Miguel Mompeán, Wenbo Li, Jixi Li, Ségolène Laage, Ansgar B. Siemer, Gunes Bozkurt, Hao Wu, Ann E. McDermott

RIPK1 Binds MCU to Mediate Induction of Mitochondrial Ca2+ Uptake and Promotes Colorectal Oncogenesis
Fanxin Zeng, Xiao Chen, Weiyi Cui, Wei Wen, Fujian Lu, Xueting Sun, Dongwei Ma, Ye Yuan, Zezhong Li, Ning Hou, Hong Zhao, Xinyu Bi, Jianjun Zhao, Jianguo Zhou, Yan Zhang, Rui-Ping Xiao, Jianqiang Cai and Xiuqin Zhang

Triad3a induces the degradation of early necrosome to limit RipK1-dependent cytokine production and necroptosis
Norah A. Alturki, Scott McComb, Ardeshir Ariana, Dikchha Rijal, Robert G. Korneluk, Shao-Cong Sun, Emad Alnemri & Subash Sad

Efferocytosis / immunogenicity

NADPH oxidase activation regulates apoptotic neutrophil clearance by murine macrophages
Juhi Bagaitkar, Jing Huang, Melody Yue Zeng, Nancy K. Pech, Darlene A. Monlish, Lizet J. Perez-Zapata, Irina Miralda, Laura G. Schuettpelz and
Mary C. Dinauer

Repeated Exposure of Epithelial Cells to Apoptotic Cells Induces the Specific Selection of an Adaptive Phenotype: Implications for Tumorigenesis
Lanfei Feng, Snezana Vujicic, Michael E Dietrich, Natalia Litbarg, Suman Setty, Angelika Antoni, Joyce Rauch and Jerrold S Levine

Apoptotic cell–induced AhR activity is required for immunological tolerance and suppression of systemic lupus erythematosus in mice and humans
Rahul Shinde  Kebria Hezaveh, Marie Jo Halaby, Andreas Kloetgen, Ankur Chakravarthy, Tiago da Silva Medina, Reema Deol, Kieran P. Manion, Yuriy Baglaenko, Maria Eldh, Sara Lamorte, Drew Wallace, Sathi Babu Chodisetti, Buvana Ravishankar, Haiyun Liu, Kapil Chaudhary, David H. Munn, Aristotelis Tsirigos, Michael Madaio, Susanne Gabrielsson, Zahi Touma, Joan Wither, Daniel D. De Carvalho & Tracy L. McGaha

Extrinsic Phagocyte-Dependent STING Signaling Dictates the Immunogenicity of Dying Cells
Jeonghyun Ahn, Tianli Xia, Ailem Rabasa Capote, Dillon Betancourt, Glen N. Barber

C. elegans Blastomeres Clear the Corpse of the Second Polar Body by LC3-Associated Phagocytosis
Gholamreza Fazeli, Maurice Stetter, Jaime N. Lisack, Ann M. Wehman



PNPT1 Release from Mitochondria during Apoptosis Triggers Decay of Poly(A) RNAs
Xing Liu, Rui Fu4, Youdong Pan, Karla F. Meza-Sosa, Zhibin Zhang, Judy Lieberman

Neutrophil extracellular traps promote macrophage pyroptosis in sepsis
Linsong Chen, Yanfeng Zhao, Dengming Lai, Peng Zhang, Yang Yang, Yuehua Li, Ke Fei, Gening Jiang & Jie Fan


Radiation-Induced Cardiovascular Toxicity: Mechanisms, Prevention, and Treatment
Johan Spetz, Javid Moslehi, Kristopher Sarosiek

Regulation of lipid peroxidation and ferroptosis in diverse species
Marcus Conrad, Valerian E. Kagan, Hülya Bayir, Gabriela C. Pagnussat,  Brian Head, Maret G. Traber and Brent R. Stockwell

Apoptotic Caspases: Multiple or Mistaken Identities?
Kate McArthur, Benjamin T. Kile


Better Together: A Hybrid Amyloid Signals Necroptosis
Dan Li, Cong Liu

RIP3 is an upregulator of aerobic metabolism and the enhanced respiration by necrosomal RIP3 feeds back on necrosome to promote necroptosis
Xingfeng Qiu, Yingying Zhang & Jiahuai Han

How do thymic epithelial cells die?
Reema Jain, Justine D. Mintern, Iris Tan, Grant Dewson, Andreas Strasser & Daniel H. D. Gray

ApoList – April 2018

Bcl-2 family proteins

PUMA amplifies necroptosis signaling by activating cytosolic DNA sensors
Dongshi Chen, Jingshan Tong, Liheng Yang, Liang Wei, Donna B. Stolz, Jian Yu, Jianke Zhang, and Lin Zhang

Increased A20-E3 ubiquitin ligase interactions in bid-deficient glia attenuate TLR3- and TLR4-induced inflammation
Sinéad Kinsella, Michael Fichtner, Orla Watters, Hans-Georg König and Jochen H. M. Prehn

The oncogenic tyrosine kinase Lyn impairs the pro-apoptotic function of Bim
Lazaro E. Aira, Elodie Villa, Pascal Colosetti, Parvati Gamas, Laurie Signetti, Sandrine Obba, Emma Proics, Fabien Gautier, Béatrice Bailly-Maitre, Arnaud Jacquel, Guillaume Robert, Frédéric Luciano, Philippe P. Juin, Jean-Ehrland Ricci, Patrick Auberger & Sandrine Marchetti

Bax retrotranslocation potentiates Bcl-xL’s antiapoptotic activity and is essential for switch-like transitions between MOMP competency and resistance
Annika Hantusch, Kushal K. Das, Ana J. García-Sáez, Thomas Brunner & Markus Rehm

Folding and binding pathways of BH3-only proteins are encoded within their intrinsically disordered sequence, not templated by partner proteins
Michael D. Crabtree, Carolina A. T. F. Mendonça, Quenton R. Bubb and Jane Clarke

Requirement of GSK-3 for PUMA induction upon loss of pro-survival PI3K signaling
Florian Schubert, Juliane Rapp, Prisca Brauns-Schubert, Lisa Schlicher, Kerstin Stock, Manuela Wissler, Martina Weiß, Céline Charvet, Christoph Borner & Ulrich Maurer

Venetoclax for patients with chronic lymphocytic leukemia who progressed during or after idelalisib therapy
Steven Coutre, Michael Choi, Richard R. Furman, Herbert Eradat, Leonard Heffner, Jeffrey A. Jones, Brenda Chyla, Lang Zhou, Suresh Agarwal, Tina Waskiewicz, Maria Verdugo, Rod A. Humerickhouse, Jalaja Potluri, William G. Wierda and Matthew S. Davids

Veronika Reidel, Johanna Kauschinger, Richard T. Hauch, Catharina Müller-Thomas, Niroshan Nadarajah, Rainer Burgkart, Burkhard Schmidt, Dirk Hempel, Anne Jacob, Julia Slotta-Huspenina, Ulrike Höckendorf, Christian Peschel, Wolfgang Kern, Torsten Haferlach, Katharina S. Götze, Stefanie Jilg, and Philipp J. Jost

Targeting PLK1 overcomes T-DM1 resistance via CDK1-dependent phosphorylation and inactivation of Bcl-2/xL in HER2-positive breast cancer
Özge Saatci, Simone Borgoni, Özge Akbulut, Selvi Durmus, Umar Raza , Erol Eyüpoğlu , Can Alkan , Aytekin Akyol , Özgür Kütük, Stefan Wiemann & Özgür Şahin

Differential role of FL-BID and t-BID during verotoxin-1-induced apoptosis in Burkitt’s lymphoma cells
Justine Debernardi, Emilie Hollville, Marc Lipinski, Joëlle Wiels & Aude Robert

Death receptors

LUBAC is essential for embryogenesis by preventing cell death and enabling haematopoiesis
Nieves Peltzer, Maurice Darding, Antonella Montinaro, Peter Draber, Helena Draberova, Sebastian Kupka, Eva Rieser, Amanda Fisher, Ciaran Hutchinson, Lucia Taraborrelli, Torsten Hartwig, Elodie Lafont, Tobias L. Haas, Yutaka Shimizu, Charlotta Böiers, Aida Sarr, James Rickard, Silvia Alvarez-Diaz, Michael T. Ashworth, Allison Beal, Tariq Enver, John Bertin, William Kaiser, Andreas Strasser, John Silke, Philippe Bouillet & Henning Walczak

Mind Bomb Regulates Cell Death during TNF Signaling by Suppressing RIPK1’s Cytotoxic Potential
Rebecca Feltham, Kunzah Jamal, Tencho Tenev, Gianmaria Liccardi, Isabel Jaco, Celia Monteiro Domingues, Otto Morris, Sidonie Wicky John, Alessandro Annibaldi, Marcella Widya, Conor J. Kearney, Danielle Clancy, Paul R. Elliott, Timo Glatter, Qi Qiao, Andrew J. Thompson, Alexey Nesvizhskii, Alexander Schmidt, David Komander, Hao Wu, Seamus Martin, Pascal Meier

S-Nitrosylation of cIAP1 Switches Cancer Cell Fate from TNFα/TNFR1-Mediated Cell Survival to Cell Death
Sabrina Romagny, Sarra Bouaouiche, Géraldine Lucchi, Patrick Ducoroy, Jean B. Bertoldo, Hernan Terenzi, Ali Bettaieb and Stéphanie Plenchette

Small tumor necrosis factor receptor biologics inhibit the tumor necrosis factor-p38 signalling axis and inflammation
Violet R. Mukaro, Alex Quach, Michelle E. Gahan, Bernadette Boog, Zhi H. Huang, Xiuhui Gao, Carol Haddad, Suresh Mahalingam, Charles S. Hii & Antonio Ferrante

Cytokeratin 8/18 protects breast cancer cell lines from TRAIL-induced apoptosis
William P. Bozza, Yaqin Zhang,  and  Baolin Zhang

The novel TRAIL-receptor agonist APG350 exerts superior therapeutic activity in pancreatic cancer cells
Karen Legler, Charlotte Hauser, Jan-Hendrik Egberts, Anna Willms, Carola Heneweer, Susann Boretius, Christoph Röcken, Claus-Christian Glüer, Thomas Becker, Michael Kluge, Oliver Hill, Christian Gieffers, Harald Fricke, Holger Kalthoff, Johannes Lemke & Anna Trauzold


Caspase-9 CARD : core domain interactions require a properly formed active site
Kristen L. Huber, Banyuhay P. Serrano and Jeanne A. Hardy

Suppressed translation as a mechanism of initiation of CASP8 (caspase 8)-dependent apoptosis in autophagy-deficient NSCLC cells under nutrient limitation
Giulia Allavena, Francesca Cuomo, Georg Baumgartner, Tadeja Bele, Alexander Yarar Sellgren, Kyaw Soe Oo, Kaylee Johnson, Vladimir Gogvadze, Boris Zhivotovsky & Vitaliy O Kaminskyy


TWEAK and RIPK1 mediate a second wave of cell death during AKI
Diego Martin-Sanchez, Miguel Fontecha-Barriuso, Susana Carrasco, Maria Dolores Sanchez-Niño, Anne von Mässenhausen, Andreas Linkermann, Pablo Cannata-Ortiz, Marta Ruiz-Ortega, Jesus Egido, Alberto Ortiz, and Ana Belen Sanz

Phenytoin inhibits necroptosis
Anne von Mässenhausen, Wulf Tonnus, Nina Himmerkus, Simon Parmentier, Danish Saleh, Diego Rodriguez, Jiraporn Ousingsawat, Rosalind L. Ang, Joel M. Weinberg, Ana B. Sanz, Alberto Ortiz, Adrian Zierleyn, Jan Ulrich Becker, Blandine Baratte, Nathalie Desban, Stéphane Bach, Ina Maria Schiessl, Shoko Nogusa, Siddharth Balachandran, Hans Joachim Anders, Adrian T. Ting, Markus Bleich, Alexei Degterev, Karl Kunzelmann, Stefan R. Bornstein, Douglas R. Green, Christian Hugo & Andreas Linkermann

Proteasome inhibition blocks necroptosis by attenuating death complex aggregation
Mohammad Ali & Edward S. Mocarski

RIP kinase 1–dependent endothelial necroptosis underlies systemic inflammatory response syndrome
Matija Zelic, Justine E. Roderick, Joanne A. O’Donnell, Jesse Lehman, Sung Eun Lim, Harish P. Janardhan, Chinmay M. Trivedi, Manolis Pasparakis, and Michelle A. Kelliher

Necroptosis promotes cell-autonomous activation of proinflammatory cytokine gene expression
Kezhou Zhu, Wei Liang, Zaijun Ma, Daichao Xu, Shuangyi Cao, Xiaojuan Lu, Nan Liu, Bing Shan, Lihui Qian & Junying Yuanhttps://www.nature.com/articles/s41419-018-0524-y

Lysosomal damage after spinal cord injury causes accumulation of RIPK1 and RIPK3 proteins and potentiation of necroptosis
Shuo Liu, Yun Li, Harry M. C. Choi, Chinmoy Sarkar, Eugene Y. Koh Junfang Wu & Marta M. Lipinski


Oxidative stress alters mitochondrial bioenergetics and modifies pancreatic cell death independently of cyclophilin D, resulting in an apoptosis-to-necrosis shift
Jane A Armstrong, Nicole J Cash, Yulin Ouyang, Jack C Morton, Michael Chvanov, Diane Latawiec, Muhammad Awais, Alexei V Tepikin, Robert Sutton and David N Criddle

Cytochrome c speeds up caspase cascade activation by blocking 14-3-3ε-dependent Apaf-1 inhibition
Carlos A. Elena-Real, Antonio Díaz-Quintana, Katiuska González-Arzola, Adrián Velázquez-Campoy, Mar Orzáez, Abelardo López-Rivas, Sergio Gil-Caballero, Miguel Á. De la Rosa & Irene Díaz-Moreno


Apoptosis-Inducing Factor (AIF) in Physiology and Disease: The Tale of a Repented Natural Born Killer
Daniele Bano,  Jochen H.M. Prehn

Neuronal Cell Death
Michael Fricker, Aviva M. Tolkovsky, Vilmante Borutaite , Michael Coleman, and Guy C. Brown

Regulation of TNF-Related Apoptosis-Inducing Ligand Signaling by Glycosylation
Olivier Micheau

Comments / other

Caspase substrates won’t be defined by a four-letter code
Paul J. Baker and Seth L. Masters

BAX and BAK at the Gates of Innate Immunity
Lorenzo Galluzzi, Claire Vanpouille-Box

Evolution of an allosteric “off switch” in apoptotic caspases
Andrew B. Herr

Venetoclax after idelalisib: relevant progress for CLL
Francesc Bosch and Michael Hallek

Selenium and iron, two elemental rivals in the ferroptotic death process
Irina Ingold and Marcus Conrad

John Sulston (1942–2018)
Martin Chalfie

ApoList – March 2018

Bcl-2 family proteins

Mcl-1 and Bcl-xL sequestration of Bak confers differential resistance to BH3-only proteins
Colin Hockings, Amber E. Alsop, Stephanie C. Fennell, Erinna F. Lee, W. Douglas Fairlie, Grant Dewson & Ruth M. Kluck

Breast Cancer Targeting through Inhibition of the Endoplasmic Reticulum-Based Apoptosis Regulator Nrh/BCL2L10
Adrien Nougarede, Nikolay Popgeorgiev, Loay Kassem, Soleilmane Omarjee, Stephane Borel, Ivan Mikaelian, Jonathan Lopez, Rudy Gadet, Olivier Marcillat, Isabelle Treilleux, Bruno O. Villoutreix, Ruth Rimokh and Germain Gillet

Anti-apoptotic A1 is not essential for lymphoma development in Eµ-Myc mice but helps sustain transplanted Eµ-Myc tumour cells
Mark Mensink, Natasha S. Anstee, Mikara Robati, Robyn L. Schenk, Marco J. Herold, Suzanne Cory & Cassandra J. Vandenberg

Transmembrane E3 ligase RNF183 mediates ER stress-induced apoptosis by degrading Bcl-xL
Yanfang Wu, Xia Li, Junying Jia, Yanpeng Zhang, Jing Li, Zhengmao Zhu, Huaqing Wang, Jie Tang, and Junjie Hu

Anna Tutusaus, Milica Stefanovic, Loreto Boix, Blanca Cucarull, Aynara Zamora, Laura Blasco, Pablo García de Frutos, Maria Reig, Jose C. Fernandez-Checa, Montserrat Marí, Anna Colell, Jordi Bruix,  and  Albert Morales

Philip D. Dunne, Helen G. Coleman, Peter Bankhead, Matthew Alderdice, Ronan T. Gray, Stephen McQuaid,Victoria Bingham, Maurice B. Loughrey, Jacqueline A. James, Amy M. B. McCorry, Alan Gilmore, Caitriona Holohan,Dirk Klingbiel, Sabine Tejpar, Patrick G. Johnston, Darragh G. McArt, Federica Di Nicolantonio, Daniel B. Longley, and  Mark Lawler

Death receptors

Fas Promotes T Helper 17 Cell Differentiation and Inhibits T Helper 1 Cell Development by Binding and Sequestering Transcription Factor STAT1
Gerd Meyer zu Horste, Dariusz Przybylski, Markus A. Schramm, Chao Wang, Alexandra Schnell, Youjin Lee, Raymond Sobel, Aviv Regev, Vijay K. Kuchroo

The Fas/Fap-1/Cav-1 complex regulates IL-1RA secretion in mesenchymal stem cells to accelerate wound healing
Xiaoxing Kou , Xingtian Xu, Chider Chen, Maria Laura Sanmillan, Tao Cai, Yanheng Zhou, Claudio Giraudo, Anh Le, Songtao Shi

DDIAS suppresses TRAIL-mediated apoptosis by inhibiting DISC formation and destabilizing caspase-8 in cancer cells
Joo-Young Im, Bo-Kyung Kim, Ji-Young Lee, Seung-Ho Park, Hyun Seung BanKyeong Eun Jung &
Misun Won

Glycogen synthase kinase-3ß inhibition promotes lysosome-dependent degradation of c-FLIPL in hepatocellular carcinoma
Na Zhang, Xiaojia Liu, Lu Liu, Zhesong Deng, Qingxuan Zeng, Weiqiang Pang, Yang Liu, Danqing Song & Hongbin Deng

Glutamine metabolism regulates FLIP expression and sensitivity to TRAIL in triple-negative breast cancer cells
Marta Mauro-Lizcano & Abelardo López-Rivas

Haley M. Simpson, Aki Furusawa, Kavitha Sadashivaiah, Curt I. Civin, and Arnob Banerjee

Anna Makowska, Lora Wahab, Till Braunschweig, Nikiforos-Ioannis Kapetanakis, Christian Vokuhl, Bernd Denecke,Lian Shen, Pierre Busson, and Udo Kontny

Caspases, metacaspases, IAPs

The anti-caspase inhibitor Q-VD-OPH prevents AIDS disease progression in SIV-infected rhesus macaques
Mireille Laforge, Ricardo Silvestre, Vasco Rodrigues, Julie Garibal, Laure Campillo-Gimenez, Shahul Mouhamad, Valérie Monceaux, Marie-Christine Cumont, Henintsoa Rabezanahary, Alain Pruvost, Anabela Cordeiro-da-Silva, Bruno Hurtrel, Guido Silvestri, Anna Senik, and Jérôme Estaquier

DNA‐damage inducible protein 1 is a conserved metacaspase substrate that is cleaved and further destabilized in yeast under specific metabolic conditions
León A. Bouvier, Gabriela T. Niemirowicz, Emir Salas‐Sarduy, Juan José Cazzulo, Vanina E. Alvarez

Effect of phosphorylation and single nucleotide polymorphisms on caspase substrates processing
Sonu Kumar & Piotr Cieplak

XIAP Regulation by MNK Links MAPK and NFκB Signaling to Determine an Aggressive Breast Cancer Phenotype
Myron K. Evans, Michael C. Brown, Joseph Geradts, Xuhui Bao, Timothy J. Robinson, Mohit Kumar Jolly, Peter B. Vermeulen, Gregory M. Palmer, Matthias Gromeier, Herbert Levine, Michael A. Morse, Steven J. Van Laere and Gayathri R. Devi


Autophagy induced during apoptosis degrades mitochondria and inhibits type I interferon secretion
Lisa M. Lindqvist, Daniel Frank, Kate McArthur, Toby A. Dite, Michael Lazarou, Jonathan S. Oakhill, Benjamin T. Kile & David L. Vaux

Necroptosis, RIPK1

CRISPR whole-genome screening identifies new necroptosis regulators and RIPK1 alternative splicing
Marinella G. Callow, Colin Watanabe, Katherine E. Wickliffe, Russell Bainer, Sarah Kummerfield, Julie Weng, Trinna Cuellar, Vasantharajan Janakiraman, Honglin Chen, Ben Chih, Yuxin Liang, Benjamin Haley, Kim Newton & Michael R. Costa

TAK1 restricts spontaneous NLRP3 activation and cell death to control myeloid proliferation
R.K. Subbarao Malireddi, Prajwal Gurung, Jayadev Mavuluri, Tejasvi Krishna Dasari, Jeffery M. Klco, Hongbo Chi, Thirumala-Devi Kanneganti

Other forms of regulated necrosis

Determination of the subcellular localization and mechanism of action of ferrostatins in suppressing ferroptosis
Michael M. Gaschler, Fanghao Hu, Huizhong Feng, Andreas Linkermann, Wei Min, and Brent R. Stockwell

Gasdermin D Exerts Anti-inflammatory Effects by Promoting Neutrophil Death
Hiroto Kambara, Fei Liu, Xiaoyu Zhang, Peng Liu, Besnik Bajrami, Yan Teng, Li Zhao, Shiyi Zhou, Hongbo Yu, Weidong Zhou, Leslie E. Silberstein, Tao Cheng, Mingzhe Han, Yuanfu Xu, Hongbo R. Luo

Contribution of TMEM16F to pyroptotic cell death
Jiraporn Ousingsawat, Podchanart Wanitchakool, Rainer Schreiber & Karl Kunzelmann

Loss of Cdk5 in breast cancer cells promotes ROS-mediated cell death through dysregulation of the mitochondrial permeability transition pore
Saranya Navaneetha Krishnan, Jesusa L. Rosales & Ki-Young Lee


Diminished apoptotic priming and ATM signalling confer a survival advantage onto aged haematopoietic stem cells in response to DNA damage
Paula Gutierrez-Martinez, Leah Hogdal, Manavi Nagai, Miriama Kruta, Rumani Singh, Kristopher Sarosiek, Andre Nussenzweig, Isabel Beerman, Anthony Letai & Derrick J. Rossi

Autophagy Inhibition Mediates Apoptosis Sensitization in Cancer Therapy by Relieving FOXO3a Turnover
Brent E. Fitzwalter, Christina G. Towers, Kelly D. Sullivan, Zdenek Andrysik, Maria Hoh, Michael Ludwig, Jim O’Prey, Kevin M. Ryan, Joaquin M. Espinosa, Michael J. Morgan, Andrew Thorburn

Reviews / comments

Perturbing mitosis for anti‐cancer therapy: is cell death the only answer?
Manuel Haschka, Gerlinde Karbon, Luca L Fava and Andreas Villunger

Nonapoptotic functions of Fas/CD95 in the immune response
Jean-Philippe Guégan and Patrick Legembre

Necroptosis in development and diseases
Bing Shan, Heling Pan, Ayaz Najafov and Junying Yuan

All about the caspase-dependent functions without cell death
Luis Alberto Baena-Lopez

FOXO3a Provides a Quickstep from Autophagy Inhibition to Apoptosis in Cancer Therapy
Patrice Codogno, Etienne Morel