ApoList – February 2023

Efferocytosis, entosis etc

Senescent cells suppress macrophage-mediated corpse removal via upregulation of the CD47-QPCT/L axis – Daniela Schloesser, Laura Lindenthal, Julia Sauer, Kyoung-Jin Chung, Triantafyllos Chavakis, Eva Griesser, Praveen Baskaran, Ulrike Maier-Habelsberger, Katrin Fundel-Clemens, Ines Schlotthauer, Carolin Kirsten Watson, Lee Kim Swee, Frederik Igney, John Edward Park, Markus S. Huber-Lang, Matthew-James Thomas, Karim Christian El Kasmi, Peter J. Murray. https://rupress.org/jcb/article/222/2/e202207097/213731

Inhomogeneous mechanotransduction defines the spatial pattern of apoptosis-induced compensatory proliferation – Takumi Kawaue, Ivan Yow, Yuping Pan, Anh Phuong Le, Yuting Lou, Mavis Loberas, Murat Shagirov, Xiang Teng, Jacques Prost, Tetsuya Hiraiwa, Benoit Ladoux, Yusuke Toyama. https://www.cell.com/developmental-cell/fulltext/S1534-5807(23)00036-9


Cellular Senescence Is Immunogenic and Promotes Antitumor Immunity – Ines Marin, Olga Boix, Andrea Garcia-Garijo, Isabelle Sirois, Adrià Caballe, Eduardo Zarzuela, Irene Ruano, Camille Stephan-Otto Attolini, Neus Prats, José A López-Domínguez, Marta Kovatcheva, Elena Garralda, Javier Muñoz, Etienne Caron, María Abad, Alena Gros, Federico Pietrocola, Manuel Serrano. https://aacrjournals.org/cancerdiscovery/article/13/2/410/716304

Senescence Rewires Microenvironment Sensing to Facilitate Antitumor Immunity – Hsuan-An Chen, Yu-Jui Ho, Riccardo Mezzadra, Jose M. Adrover, Ryan Smolkin, Changyu Zhu, Katharina Woess, Nicholas Bernstein, Georgia Schmitt, Linda Fong, Wei Luan, Alexandra Wuest, Sha Tian, Xiang Li, Caroline Broderick, Ronald C. Hendrickson, Mikala Egeblad, Zhenghao Chen, Direna Alonso-Curbelo, Scott W. Lowe. https://aacrjournals.org/cancerdiscovery/article/13/2/432/716311

Senescent cancer cell vaccines induce cytotoxic T cell responses targeting primary tumors and disseminated tumor cells – Yue Liu, Joanna Pagacz, Donald J Wolfgeher, Kenneth D Bromerg, Jacob V Gorman and Stephen J Kron. https://jitc.bmj.com/content/11/2/e005862

Bcl-2 family proteins

Peptides from human BNIP5 and PXT1 and non-native binders of pro-apoptotic BAK can directly activate or inhibit BAK-mediated membrane permeabilization – Aguilar F, Yu S, Grant RA, Swanson S, Ghose D, Su BG, Sarosiek KA, Keating AE. https://www.cell.com/structure/fulltext/S0969-2126(23)00001-1

Death receptors

Negligible role of TRAIL death receptors in cell death upon endoplasmic reticulum stress in B-cell malignancies – Francesca Favaro, Demi Both, Ingrid A. M. Derks, Marcel Spaargaren, Cristina Muñoz-Pinedo and Eric Eldering. https://www.nature.com/articles/s41389-023-00450-w

Autoinhibitory structure of preligand association state implicates a new strategy to attain effective DR5 receptor activation – Gang Du, Linlin Zhao, Yumei Zheng, Anissa Belfetmi, Tiantian Cai, Boying Xu, Karen Heyninck, Kim Van Den Heede, Marie-Ange Buyse, Pietro Fontana, Michael Bowman, Lih-Ling Lin, Hao Wu and James Jeiwen Chou. https://www.nature.com/articles/s41422-022-00755-2

TSC2 regulates tumor susceptibility to TRAIL‐mediated T‐cell killing by orchestrating mTOR signaling – Chun-Pu Lin, Joleen J H Traets, David W Vredevoogd, Nils L Visser, Daniel S Peeper. https://www.embopress.org/doi/abs/10.15252/embj.2022111614

Caspases and IAPs

Caspase-8 as a novel mediator linking Src kinase signaling to enhanced glioblastoma malignancy – Claudia Contadini, Alessandra Ferri, Marta Di Martile, Claudia Cirotti, Donatella Del Bufalo, Francesca De Nicola, Matteo Pallocca, Maurizio Fanciulli, Francesca Sacco, Gloria Donninelli, Alessia Capone, Elisabetta Volpe, Nadine Keller, Shunichiro Miki, Daisuke Kawauchi, Dwayne Stupack, Frank Furnari and Daniela Barilà. https://www.nature.com/articles/s41418-022-01093-x

Conserved folding landscape of monomeric initiator caspases – Mithun Nag, A. Clay Clark. https://www.jbc.org/article/S0021-9258(23)00207-7/fulltext

Structural basis for regulation of apoptosis and autophagy by the BIRC6/SMAC complex – Julian F. Ehrmann, Daniel B. Grabarczyk, Maria Heinke, Luiza Deszcz, Robert Kurzbauer, Otto Hudecz, Alexandra Shulkina, Rebeca Gogova, Anton Meinhart, Gijs A. Versteeg, Tim Clausen. https://www.science.org/doi/abs/10.1126/science.ade8873

Structural basis for SMAC-mediated antagonism of caspase inhibition by the giant ubiquitin ligase BIRC6 – Larissa Dietz, Cara J. Ellison, Carlos Riechmann, C. Keith Cassidy, F. Daniel Felfoldi, Adán Pinto-Fernández, Benedikt M. Kessler, Paul R. Elliott. https://www.science.org/doi/abs/10.1126/science.ade8840

Structures of BIRC6-client complexes provide a mechanism of Smac-mediated release of caspases – Moritz Hunkeler, Cyrus Y. Jin, Eric S. Fischer. https://www.science.org/doi/abs/10.1126/science.ade5750

Necroptosis and asssociated signals

Telomere-to-mitochondria signalling by ZBP1 mediates replicative crisis – Joe Nassour, Lucia Gutierrez Aguiar, Adriana Correia, Tobias T. Schmidt, Laura Mainz, Sara Przetocka, Candy Haggblom, Nimesha Tadepalle, April Williams, Maxim N. Shokhirev, Semih C. Akincilar, Vinay Tergaonkar, Gerald S. Shadel and Jan Karlseder. https://www.nature.com/articles/s41586-023-05710-8


Caspase‐8‐driven apoptotic and pyroptotic crosstalk causes cell death and IL‐1β release in X‐linked inhibitor of apoptosis (XIAP) deficiency – Sebastian A Hughes, Meng Lin, Ashley Weir, Bing Huang, Liya Xiong, Ngee Kiat Chua, Jiyi Pang, Jascinta P Santavanond, Rochelle Tixeira, Marcel Doerflinger, Yexuan Deng, Chien-Hsiung Yu, Natasha Silke, Stephanie A Conos, Daniel Frank, Daniel S Simpson, James M Murphy, Kate E Lawlor, Jaclyn S Pearson, John Silke, Marc Pellegrini, Marco J Herold, Ivan K H Poon, Seth L Masters, Mingsong Li, Qin Tang, Yuxia Zhang, Maryam Rashidi, Lanlan Geng, James E Vince. https://www.embopress.org/doi/abs/10.15252/embj.2021110468

Elevated Methionine Flux Drives Pyroptosis Evasion in Persister Cancer Cells – Asmaa El-Kenawi, Anders Berglund, Veronica Estrella, Yonghong Zhang, Min Liu, Ryan M. Putney, Sean J. Yoder, Joseph Johnson, Joel Brown, Robert Gatenby. https://aacrjournals.org/cancerres/article/83/5/720/716681


BCL-2 protein family: attractive targets for cancer therapy – Deeksha Kaloni, Sarah T Diepstraten, Andreas Strasser, Gemma L Kelly. https://link.springer.com/article/10.1007/s10495-022-01780-7

Drosophila caspases as guardians of host-microbe interactions – Christa Kietz and Annika Meinander. https://www.nature.com/articles/s41418-022-01038-4

Harnessing TRAIL-induced cell death for cancer therapy: a long walk with thrilling discoveries – Antonella Montinaro and Henning Walczak. https://www.nature.com/articles/s41418-022-01059-z

Immunogenic cell death in cancer: concept and therapeutic implications – Lorenzo Galluzzi, Oliver Kepp, Erik Hett, Guido Kroemer and Francesco M. Marincola. https://translational-medicine.biomedcentral.com/articles/10.1186/s12967-023-04017-6

Sub-lethal signals in the mitochondrial apoptosis apparatus: pernicious by-product or physiological event? – Georg Häcker and Aladin Haimovici. https://www.nature.com/articles/s41418-022-01058-0

When cell death goes wrong: inflammatory outcomes of failed apoptosis and mitotic cell death – Florian J. Bock and Joel S. Riley. https://www.nature.com/articles/s41418-022-01082-0

Cell death and inflammation during obesity: “Know my methods, WAT(son)” – Ximena Hildebrandt, Mohamed Ibrahim and Nieves Peltzer. https://www.nature.com/articles/s41418-022-01062-4

Cellular senescence: beneficial, harmful, and highly complex – Darren J. Baker, Masashi Narita, Pura Muñoz-Cánoves

Special issue: https://febs.onlinelibrary.wiley.com/toc/17424658/2023/290/5

Comments / other

When aging gets on the way of disposal: Senescent cell suppression of efferocytosis – Carla V. Rothlin, Sourav Ghosh. https://rupress.org/jcb/article/222/2/e202212023/213792

Death receptor 5 rises to the occasion – Lixin Zheng, Yikun Yao and Michael J. Lenardo. https://www.nature.com/articles/s41422-022-00772-1

Apoptosis, autophagy, and cancer: the critical role Genes & Development played in paradigm shifts – Eileen White. http://genesdev.cshlp.org/content/37/1-2/59.extract?etoc

Senescent Cancer Cells Are Vulnerable to Extrinsic Apoptosis Pathway Activation. https://aacrjournals.org/cancerdiscovery/article-abstract/13/2/256/716286


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