Caspases
Cell survival following direct executioner-caspase activation – Maddalena Nano, James A. Mondo, Jacob Harwood, Varuzhan Balasanyan and Denise J. Montell. https://www.pnas.org/doi/10.1073/pnas.2216531120
Endothelial Caspase-8 prevents fatal necroptotic hemorrhage caused by commensal bacteria – Stefanie M. Bader, Simon P. Preston, Katie Saliba, Adam Lipszyc, Zoe L. Grant, Liana Mackiewicz, Andrew Baldi, Anne Hempel, Michelle P. Clark, Thanushi Peiris, William Clow, Jan Bjelic, Michael D. Stutz, Philip Arandjelovic, Jack Teale, Fashuo Du, Leigh Coultas, James M. Murphy, Cody C. Allison, Marc Pellegrini and Andre L. Samson. https://www.nature.com/articles/s41418-022-01042-8
Role of Caspase-10-P13tBID axis in erythropoiesis regulation – Mathilde Lamarque, Emilie-Fleur Gautier, François Rodrigues, Flavia Guillem, Elisa Bayard, Cédric Broussard, Thiago Maciel Trovati, Jean-Benoît Arlet, Patrick Mayeux, Olivier Hermine and Geneviève Courtois. https://www.nature.com/articles/s41418-022-01066-0
X‐linked inhibitor of apoptosis protein represents a promising therapeutic target for relapsed/refractory ALL – Michela Carlet, Karin Schmelz, Jenny Vergalli, Tobias Herold, Daniela Senft, Vindi Jurinovic, Thomas Hoffmann, Jutta Proba, Nina Weichert, Christian Junghanß, Mareike Roth, Georg Eschenburg, Malwine Barz, Günter Henze, Cornelia Eckert, Angelika Eggert, Johannes Zuber, Patrick Hundsdoerfer, Irmela Jeremias. https://www.embopress.org/doi/full/10.15252/emmm.202114557
Caspase-9 driven murine model of selective cell apoptosis and efferocytosis – Lena Batoon, Amy J. Koh, Rahasudha Kannan, Laurie K. McCauley and Hernan Roca. https://www.nature.com/articles/s41419-023-05594-6
Bcl-2 family proteins
Co-targeting BCL-XL and MCL-1 with DT2216 and AZD8055 synergistically inhibit small-cell lung cancer growth without causing on-target toxicities in mice – Sajid Khan, Patrick Kellish, Nick Connis, Dinesh Thummuri, Janet Wiegand, Peiyi Zhang, Xuan Zhang, Vivekananda Budamagunta, Nan Hua, Yang Yang, Umasankar De, Lingtao Jin, Weizhou Zhang, Guangrong Zheng, Robert Hromas, Christine Hann, Maria Zajac-Kaye, Frederic J. Kaye and Daohong Zhou. https://www.nature.com/articles/s41420-022-01296-8
Evidence for existence of an apoptosis-inducing BH3-only protein, sayonara, in Drosophila – Yuko Ikegawa, Christophe Combet, Mathieu Groussin, Vincent Navratil, Sabrina Safar-Remali, Takuya Shiota, Abdel Aouacheria, Sa Kan Yoo. https://www.embopress.org/doi/full/10.15252/embj.2021110454
Cardiomyocyte differentiation from human induced pluripotent stem cells is delayed following knockout of Bcl-2 – Tim Vervliet, Robin Duelen, Ankit Pradhan, Rita La Rovere, H. Llewelyn Roderick, Maurilio Sampaolesi. https://journals.biologists.com/jcs/article-abstract/136/2/jcs260216/286722
Transient targeting of BIM-dependent adaptive MCL1 preservation enhances tumor response to molecular therapeutics in non-small cell lung cancer – Kaixuan Shi, Haijiao Lu, Zhenfeng Zhang, Yujie Fu, Jie Wu, Shichao Zhou, Pengfei Ma, Kaiyan Ye, Shengzhe Zhang, Hailei Shi, Weiping Shi, Mei-Chun Cai, Xiaojing Zhao, Zhuang Yu, Jian Tang and Guanglei Zhuang. https://www.nature.com/articles/s41418-022-01064-2
Mechanisms of MCL-1 Protein Stability Induced by MCL-1 Antagonists in B-Cell Malignancies – Shady I. Tantawy, Aloke Sarkar, Stefan Hubner, Zhi Tan, William G. Wierda, Abdelraouf Eldeib, Shuxing Zhang, Steven Kornblau, Varsha Gandhi. https://aacrjournals.org/clincancerres/article-abstract/29/2/446/713974
Modulation of RNA splicing enhances response to BCL2 inhibition in leukemia – Eric Wang, Jose Mario Bello Pineda, Won Jun Kim, Sisi Chen, Jessie Bourcier, Maximilian Stahl, Simon J. Hogg, Jan Phillipp Bewersdorf, Cuijuan Han, Michael E. Singer, Daniel Cui, Caroline E. Erickson, Steven M. Tittley, Alexander V. Penson, Katherine Knorr, Robert F. Stanley, Jahan Rahman, Gnana Krishnamoorthy, James A. Fagin, Emily Creger, Elizabeth McMillan, Chi-Ching Mak, Matthew Jarvis, Carine Bossard, Darrin M. Beaupre, Robert K. Bradley, Omar Abdel-Wahab. https://www.cell.com/cancer-cell/fulltext/S1535-6108(22)00588-8
Death receptors
NF-κB/RelA controlled A20 limits TRAIL-induced apoptosis in pancreatic cancer – Claudia Geismann, Charlotte Hauser, Frauke Grohmann, Christian Schneeweis, Nico Bölter, Jan-Paul Gundlach, Günter Schneider, Christoph Röcken, Christian Meinhardt, Heiner Schäfer, Stefan Schreiber and Alexander Arlt. https://www.nature.com/articles/s41419-022-05535-9
Necroptosis and RIPK
RIPK1 blocks T cell senescence mediated by RIPK3 and caspase-8 – Takayuki Imanishi, Midori Unno, Natsumi Yoneda, Yasutaka Motomura, Miho Mochizuki, Takaharu Sasaki, Manolis Pasparakis, Takashi Saito. https://www.science.org/doi/full/10.1126/sciadv.add6097
OASL phase condensation induces amyloid-like fibrillation of RIPK3 to promote virus-induced necroptosis – Shin-Ae Lee, Lin-Chun Chang, WooRam Jung, James W. Bowman, Dokyun Kim, Weiqiang Chen, Suan-Sin Foo, Youn Jung Choi, Un Yung Choi, Anna Bowling, Ji-Seung Yoo and Jae U. Jung. https://www.nature.com/articles/s41556-022-01039-y
Myeloid-derived MIF drives RIPK1-mediated cerebromicrovascular endothelial cell death to exacerbate ischemic brain injury – Yan Li, Chengyu Zou, Chen Chen, Sixuan Li, Ziyu Zhu, Qiuyue Fan, Rui Pang, Fengshi Li, Zengai Chen, Zhenghong Wang, Weifeng Yu, Junying Yuan and Peiying Li. https://www.pnas.org/doi/10.1073/pnas.2219091120
TRAF6 regulates the abundance of RIPK1 and inhibits the RIPK1/RIPK3/MLKL necroptosis signaling pathway and affects the progression of colorectal cancer – Penghang Lin, Chunlin Lin, Ruofan He, Hui Chen, Zuhong Teng, Hengxin Yao, Songyi Liu, Robert M. Hoffman, Jianxin Ye and Guangwei Zhu. https://www.nature.com/articles/s41419-022-05524-y
Pyroptosis
Gasdermin D pore-forming activity is redox-sensitive – Pascal Devant, Elvira Boršić, Elsy M. Ngwa, Haopeng Xiao, Edward T. Chouchani, Jay R. Thiagarajah, Iva Hafner-Bratkovič, Charles L. Evavold, Jonathan C. Kagan. https://www.cell.com/cell-reports/fulltext/S2211-1247(23)00019-0
NET formation is independent of gasdermin D and pyroptotic cell death – Darko Stojkov, Meike J. Claus, Evelyne Kozlowski, Kevin Oberson, Olivier P. Schären, Charaf Benarafa, Shida Yousefi, Hans-Uwe Simon. https://www.science.org/doi/abs/10.1126/scisignal.abm0517
Protein engineering reveals that gasdermin A preferentially targets mitochondrial membranes over the plasma membrane during pyroptosis – Hannah C. Kondolf, Dana A. D’Orlando, George R. Dubyak, Derek W. Abbott. https://www.jbc.org/article/S0021-9258(23)00040-6/fulltext
Reviews
Endogenous and imposed determinants of apoptotic vulnerabilities in cancer – Kristopher A. Sarosiek, Kris C. Wood. https://www.cell.com/trends/cancer/fulltext/S2405-8033(22)00224-2
Apoptotic mitochondrial poration by a growing list of pore-forming BCL-2 family proteins – Tudor Moldoveanu. https://onlinelibrary.wiley.com/doi/abs/10.1002/bies.202200221
The web of death: the expanding complexity of necroptotic signaling – Christopher R. Horne, André L. Samson, James M. Murphy. https://www.cell.com/trends/cell-biology/fulltext/S0962-8924(22)00139-8
Arming a killer: mitochondrial regulation of CD8+ T cell cytotoxicity – Miriam Lisci, Gillian M. Griffiths. https://www.cell.com/trends/cell-biology/fulltext/S0962-8924(22)00138-6
Comments
Poking holes in pyroptosis paradigms – Leslie K. Ferrarelli. https://www.science.org/doi/full/10.1126/scisignal.adg7522
Monocytes: A Promising New TRAIL in Ovarian Cancer Cell Therapy – Stephanie Chow; Oliver Dorigo. https://aacrjournals.org/clincancerres/article-abstract/29/2/299/713966
Profile of Vishva M. Dixit – Jennifer Viegas. https://www.pnas.org/doi/10.1073/pnas.2219482119
Apoptosis and cell death 