ApoList – September 2022

Bcl-2 family proteins

Small molecule SJ572946 activates BAK to initiate apoptosis – Giridhar Sekar, Geetika Singh, Xingping Qin, Cristina D. Guibao, Brittany Schwam, Zintis Inde, Christy R. Grace, Weixing Zhang, P. Jake Slavish, Wenwei Lin, Taosheng Chen, Richard E. Lee, Zoran Rankovic, Kristopher Sarosiek, Tudor Moldoveanu. https://www.cell.com/iscience/fulltext/S2589-0042(22)01336-0

Structure of the BAK-activating antibody 7D10 bound to BAK reveals an unexpected role for the α1-α2 loop in BAK activation – Adeline Y. Robin, Michelle S. Miller, Sweta Iyer, Melissa X. Shi, Ahmad Z. Wardak, Daisy Lio, Nicholas A. Smith, Brian J. Smith, Richard W. Birkinshaw, Peter E. Czabotar, Ruth M. Kluck and Peter M. Colman. https://www.nature.com/articles/s41418-022-00961-w

BET inhibition induces vulnerability to MCL1 targeting through upregulation of fatty acid synthesis pathway in breast cancer – Gonghong Yan, Augustin Luna, Heping Wang, Behnaz Bozorgui, Xubin Li, Maga Sanchez, Zeynep Dereli, Nermin Kahraman, Goknur Kara, Xiaohua Chen, Caishang Zheng, Daniel McGrail, Nidhi Sahni, Yiling Lu, Ozgun Babur, Murat Cokol, Bora Lim, Bulent Ozpolat, Chris Sander, Gordon B. Mills, Anil Korkut. https://www.cell.com/cell-reports/fulltext/S2211-1247(22)01128-7

Chlamydia trachomatis inhibits apoptosis in infected cells by targeting the pro-apoptotic proteins Bax and Bak – Collins Waguia Kontchou, Ian E. Gentle, Arnim Weber, Axel Schoeniger, Frank Edlich and Georg Häcker. https://www.nature.com/articles/s41418-022-00995-0

Exploiting endogenous and therapy-induced apoptotic vulnerabilities in immunoglobulin light chain amyloidosis with BH3 mimetics – Cameron S. Fraser, Johan K. E. Spetz, Xingping Qin, Adam Presser, Jonathan Choiniere, Chendi Li, Stacey Yu, Frances Blevins, Aaron N. Hata, Jeffrey W. Miller, Gary A. Bradshaw, Marian Kalocsay, Vaishali Sanchorawala, Shayna Sarosiek and Kristopher A. Sarosiek. https://www.nature.com/articles/s41467-022-33461-z

Death receptors

PP6 negatively modulates LUBAC-mediated M1-ubiquitination of RIPK1 and c-FLIPL to promote TNFα-mediated cell death – Guowei Wu, Dekang Li, Wei Liang, Weimin Sun, Xingxing Xie, Yilun Tong, Bing Shan, Mengmeng Zhang, Xiaojuan Lu, Junying Yuan and Ying Li. https://www.nature.com/articles/s41419-022-05206-9


Caspase-3–Induced Activation of SREBP2 Drives Drug Resistance via Promotion of Cholesterol Biosynthesis in Hepatocellular Carcinoma – Etienne Ho Kit Mok, Carmen Oi Ning Leung, Lei Zhou, Martina Mang Leng Lei, Hoi Wing Leung, Man Tong, Tin Lok Wong, Eunice Yuen Ting Lau, Irene Oi Lin Ng, Jin Ding, Jing Ping Yun, Jun Yu, Hui Lian Zhu, Chi Ho Lin, Dan Lindholm, Kit Sum Leung, Jonathan D. Cybulski, David M. Baker, Stephanie M, Terence Kin Wah Lee. https://aacrjournals.org/cancerres/article-abstract/82/17/3102/708279

Coronaviruses exploit a host cysteine-aspartic protease for replication – Hin Chu, Yuxin Hou, Dong Yang, Lei Wen, Huiping Shuai, Chaemin Yoon, Jialu Shi, Yue Chai, Terrence Tsz-Tai Yuen, Bingjie Hu, Cun Li, Xiaoyu Zhao, Yixin Wang, Xiner Huang, Kin Shing Lee, Cuiting Luo, Jian-Piao Cai, Vincent Kwok-Man Poon, Chris Chung-Sing Chan, Anna Jinxia Zhang, Shuofeng Yuan, Ko-Yung Sit, Dominic Chi-Chung Foo, Wing-Kuk Au, Kwok-Yung Yuen. https://www.nature.com/articles/s41586-022-05148-4


Membrane permeabilization is mediated by distinct epitopes in mouse and human orthologs of the necroptosis effector, MLKL – Ashish Sethi, Christopher R. Horne, Cheree Fitzgibbon, Karyn Wilde, Katherine A. Davies, Sarah E. Garnish, Annette V. Jacobsen, André L. Samson, Joanne M. Hildebrand, Ahmad Wardak, Peter E. Czabotar, Emma J. Petrie, Paul R. Gooley and James M. Murphy. https://www.nature.com/articles/s41418-022-00965-6



Gasdermin D-deficient mice are hypersensitive to acute kidney injury – Wulf Tonnus, Francesca Maremonti, Alexia Belavgeni, Markus Latk, Yoshihiro Kusunoki, Anne Brucker, Anne von Mässenhausen, Claudia Meyer, Sophie Locke, Florian Gembardt, Kristina Beer, Paul Hoppenz, Jan U. Becker, Christian Hugo, Hans-Joachim Anders, Stefan R. Bornstein, Feng Shao and Andreas Linkermann. https://www.nature.com/articles/s41419-022-05230-9


The MARCHF6 E3 ubiquitin ligase acts as an NADPH sensor for the regulation of ferroptosis – Kha The Nguyen, Sang-Hyeon Mun, Jihye Yang, Jongeun Lee, Ok-Hee Seok, Eunjeong Kim, Dasom Kim, So Young An, Dong-Young Seo, Jeong-Yong Suh, Yoontae Lee and Cheol-Sang Hwang. https://www.nature.com/articles/s41556-022-00973-1


Induction of tumor cell autosis by myxoma virus-infected CAR-T and TCR-T cells to overcome primary and acquired resistance – Ningbo Zheng, Jing Fang, Gang Xue, Ziyu Wang, Xiaoyin Li, Mengshi Zhou, Guangxu Jin, Masmudur M. Rahman, Grant McFadden, Yong Lu. https://www.cell.com/cancer-cell/fulltext/S1535-6108(22)00357-9

NRF2 mediates melanoma addiction to GCDH by modulating apoptotic signalling – Sachin Verma, David Crawford, Ali Khateb, Yongmei Feng, Eduard Sergienko, Gaurav Pathria, Chen-Ting Ma, Steven H. Olson, David Scott, Rabi Murad, Eytan Ruppin, Michael Jackson and Ze’ev A. Ronai.  https://www.nature.com/articles/s41556-022-00985-x


Necroptosis at a glance – Kidong Kang, Christa Park, Francis Ka-Ming Chan. https://journals.biologists.com/jcs/article-abstract/135/17/jcs260091/276621

MLKL post-translational modifications: road signs to infection, inflammation and unknown destinations – Gianmaria Liccardi and Alessandro Annibaldi. https://www.nature.com/articles/s41418-022-01061-5

Monitoring yeast regulated cell death: trespassing the point of no return to loss of plasma membrane integrity – António Rego, António Ribeiro, Manuela Côrte-Real, Susana Rodrigues Chaves. https://link.springer.com/article/10.1007/s10495-022-01748-7


A conversation with Vishva Dixit – Ushma S. Neill. https://www.jci.org/articles/view/164341

Navigating ferroptosis via an NADPH sensor – Chao Mao and Boyi Gan. https://www.nature.com/articles/s41556-022-00963-3

The power of an idea: Andrew Wyllie – Richard A. Lockshin and Margaret C. Cummings


Pro-ferroptotic fatty acid metabolism renders cancer cells immunogenic – Oliver Kepp, Guido Kroemer. https://www.cell.com/trends/cancer/fulltext/S2405-8033(22)00089-9


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