Bcl-2 family proteins
Some mice lacking intrinsic, as well as death receptor induced apoptosis and necroptosis, can survive to adulthood – Francine F. S. Ke, Kerstin Brinkmann, Anne K. Voss and Andreas Strasser. https://www.nature.com/articles/s41419-022-04731-x
Augmenting NK cell-based immunotherapy by targeting mitochondrial apoptosis – Rongqing Pan, Jeremy Ryan, Deng Pan, Kai W. Wucherpfennig, Anthony Letai. https://www.cell.com/cell/fulltext/S0092-8674(22)00340-3
Single-cell transcriptomics identifies Mcl-1 as a target for senolytic therapy in cancer – Martina Troiani, Manuel Colucci, Mariantonietta D’Ambrosio, Ilaria Guccini, Emiliano Pasquini, Angelica Varesi, Aurora Valdata, Simone Mosole, Ajinkya Revandkar, Giuseppe Attanasio, Andrea Rinaldi, Anna Rinaldi, Marco Bolis, Pietro Cippà and Andrea Alimonti. https://www.nature.com/articles/s41467-022-29824-1
Efficacy and specificity of inhibitors of BCL-2 family protein interactions assessed by affinity measurements in live cells – Elizabeth J. Osterlund, Nehad Hirmiz, James M. Pemberton, Adrien Nougarède, Qian Liu, Brian Leber, Qiyin Fang, David W. Andrews. https://www.science.org/doi/full/10.1126/sciadv.abm7375
MEK and MCL-1 sequential inhibition synergize to enhance rhabdomyosarcoma treatment – Clara Alcon, Fernando Martín, Estela Prada, Jaume Mora, Aroa Soriano, Gabriela Guillén, Soledad Gallego, Josep Roma, Josep Samitier, Alberto Villanueva and Joan Montero. https://www.nature.com/articles/s41420-022-00959-w
DRP1 interacts directly with BAX to induce its activation and apoptosis – Andreas Jenner, Aida Peña-Blanco, Raquel Salvador-Gallego, Begoña Ugarte-Uribe, Cristiana Zollo, Tariq Ganief, Jan Bierlmeier, Markus Mund, Jason E Lee, Jonas Ries, Dirk Schwarzer, Boris Macek, Ana J Garcia-Saez. https://www.embopress.org/doi/full/10.15252/embj.2021108587
Death receptors
TNF-α sculpts a maturation process in vivo by pruning tolerogenic dendritic cells – Courtney A. Iberg, Jessica Bourque, Ian Fallahee, Sungho Son, Daniel Hawiger. https://www.cell.com/cell-reports/fulltext/S2211-1247(22)00409-0
CDK4/6 Inhibition Suppresses p73 Phosphorylation and Activates DR5 to Potentiate Chemotherapy and Immune Checkpoint Blockade – Jingshan Tong, Xiao Tan, Xiangping Song, Man Gao, Denise Risnik, Suisui Hao, Kaylee Ermine, Peng Wang, Hua Li, Yi Huang, Jian Yu, Lin Zhang. https://aacrjournals.org/cancerres/article-abstract/82/7/1340/694058
Inflammation induces pro-NETotic neutrophils via TNFR2 signaling – Friederike Neuenfeldt, Jan Christoph Schumacher, Ricardo Grieshaber-Bouyer, Jüri Habicht, Jutta Schröder-Braunstein, Annika Gauss, Uta Merle, Beate Niesler, Niko Heineken, Alexander Dalpke, Matthias M. Gaida, Thomas Giese, Stefan Meuer, Yvonne Samstag, Guido Wabnitz. https://www.cell.com/cell-reports/fulltext/S2211-1247(22)00471-5?dgcid=raven_jbs_etoc_email
Caspases
Non-apoptotic activation of Drosophila caspase-2/9 modulates JNK signaling, the tumor microenvironment, and growth of wound-like tumors – Derek Cui Xu, Li Wang, Kenneth M. Yamada, Luis Alberto Baena-Lopez. https://www.cell.com/cell-reports/fulltext/S2211-1247(22)00479-X
The caspase-2 substrate p54nrb exhibits a multifaceted role in tumor cell death susceptibility via gene regulatory functions – Madeleine Eichler, Ute Distler, Usman Nasrullah, Aswini Krishnan, Manuel Kaulich, Koraljka Husnjak, Wolfgang Eberhardt, Krishnaraj Rajalingam, Stefan Tenzer, Josef Pfeilschifter and Gergely Imre. https://www.nature.com/articles/s41419-022-04829-2
Necroptosis
Mosaic composition of RIP1–RIP3 signalling hub and its role in regulating cell death – Xin Chen, Rongfeng Zhu, Jinjin Zhong, Yongfa Ying, Wenxin Wang, Yating Cao, Hanyi Cai, Xiang Li, Jianwei Shuai and Jiahuai Han. https://www.nature.com/articles/s41556-022-00854-7
The interferon-stimulated gene RIPK1 regulates cancer cell intrinsic and extrinsic resistance to immune checkpoint blockade – Lisa Cucolo, Qingzhou Chen, Jingya Qiu, Yongjun Yu, Max Klapholz, Krista A. Budinich, Zhaojun Zhang, Yue Shao, Igor E. Brodsky, Martha S. Jordan, D. Gary Gilliland, Nancy R. Zhang, Junwei Shi, Andy J. Minn. https://www.cell.com/immunity/fulltext/S1074-7613(22)00130-3
CAMK2/CaMKII activates MLKL in short-term starvation to facilitate autophagic flux – Qionghui Zhan, Jaepyo Jeon, Ying Li, Yu Huang, Jian Xiong, Qiaochu Wang, Tian-Le Xu, Yong Li, Fu-Hai Ji, Guangwei Du and Michael X Zhu. https://www.tandfonline.com/doi/full/10.1080/15548627.2021.1954348
MLKL deficiency in BrafV600EPten−/− melanoma model results in a modest delay of nevi development and reduced lymph node dissemination in male mice – Sofie Martens, Nozomi Takahashi, Gillian Blancke, Niels Vandamme, Hanne Verschuere, Tatyana Divert, Marnik Vuylsteke, Geert Berx and Peter Vandenabeele. https://www.nature.com/articles/s41419-022-04819-4
Pyroptosis
Activation and manipulation of inflammasomes and pyroptosis during bacterial infections – Elliott M. Bernard, Petr Broz. https://portlandpress.com/biochemj/article-abstract/479/7/867/231175
Ferroptosis
CD8+ T cells and fatty acids orchestrate tumor ferroptosis and immunity via ACSL4 – Peng Liao, Weimin Wang, Weichao Wang, Ilona Kryczek, Xiong Li, Yingjie Bian, Amanda Sell, Shuang Wei, Sara Grove, Jeffrey K. Johnson, Paul D. Kennedy, Miguel Gijón, Yatrik M. Shah, Weiping Zou. https://www.cell.com/cancer-cell/fulltext/S1535-6108(22)00036-8
Ferroptosis in plants: regulation of lipid peroxidation and redox status – Ayelén Mariana Distéfano, Gabriel Alejandro López, Victoria Bauer, Eduardo Zabaleta, Gabriela Carolina Pagnussat. https://portlandpress.com/biochemj/article-abstract/479/7/857/231174
Efferocytosis, entosis etc
Stem cell conversion to the cardiac lineage requires nucleotide signalling from apoptosing cells – Loic Fort, Vivian Gama and Ian G. Macara. https://www.nature.com/articles/s41556-022-00888-x
Macrophages use apoptotic cell-derived methionine and DNMT3A during efferocytosis to promote tissue resolution – Patrick B. Ampomah, Bishuang Cai, Santosh R. Sukka, Brennan D. Gerlach, Arif Yurdagul Jr, Xiaobo Wang, George Kuriakose, Lancia N. F. Darville, Yan Sun, Simone Sidoli, John M. Koomen, Alan R. Tall and Ira Tabas. https://www.nature.com/articles/s42255-022-00551-7
Miscellanous
Early SRC activation skews cell fate from apoptosis to senescence – Carlos Anerillas, Allison B. Herman, Martina Rossi, Rachel Munk, Elin Lehrmann, Jennifer L. Martindale, Chang-Yi Cui, Kotb Abdelmohsen, Supriyo De, Myriam Gorospe. https://www.science.org/doi/full/10.1126/sciadv.abm0756
NAMPT-dependent NAD+ salvage is crucial for the decision between apoptotic and necrotic cell death under oxidative stress – Takuto Nishida, Isao Naguro and Hidenori Ichijo. https://www.nature.com/articles/s41420-022-01007-3
Yeast cell death pathway requiring AP-3 vesicle trafficking leads to vacuole/lysosome membrane permeabilization -Zachary D. Stolp, Madhura Kulkarni, Yining Liu, Chengzhang Zhu, Alizay Jalisi, Si Lin, Arturo Casadevall, Kyle W. Cunningham, Fernando J. Pineda, Xinchen Teng, J. Marie Hardwick. https://www.cell.com/cell-reports/fulltext/S2211-1247(22)00399-0
Reviews / comments
Immunogenic cell stress and death – Guido Kroemer, Claudia Galassi, Laurence Zitvogel and Lorenzo Galluzzi. https://www.nature.com/articles/s41590-022-01132-2
RIPK1 and RIPK3 form mosaic necrosomes – Weiwei Qi and Junying Yuan. https://www.nature.com/articles/s41556-022-00879-y
RIP(K)ing away immunotherapy resistance – Mira A. Patel, Sohail F. Tavazoie. https://www.cell.com/immunity/fulltext/S1074-7613(22)00133-9
Dying cell-derived SAM switches off inflammation – Roel P. H. De Maeyer and Derek W. Gilroy. https://www.nature.com/articles/s42255-022-00556-2
EMBO Journal cover – Jenner et al
https://www.embopress.org/cms/asset/9ba6ed7a-df0b-4d7c-9afb-268eb7547e11/embj.v41.8.cover.jpg
Apoptosis and cell death 
