Bcl-2 family proteins
The interplay between BAX and BAK tunes apoptotic pore growth to control mitochondrial-DNA-mediated inflammation – Katia Cosentino, Vanessa Hertlein, Andreas Jenner, Timo Dellmann, Milos Gojkovic, Aida Peña-Blanco, Shashank Dadsena, Noel Wajngarten, John S.H. Danial, Jervis Vermal Thevathasan, Markus Mund, Jonas Ries, Ana J. Garcia-Saez. https://www.cell.com/molecular-cell/fulltext/S1097-2765(22)00008-9
Co-targeting of BAX and BCL-XL proteins broadly overcomes resistance to apoptosis in cancer – Andrea Lopez, Denis E. Reyna, Nadege Gitego, Felix Kopp, Hua Zhou, Miguel A. Miranda-Roman, Lars Ulrik Nordstrøm, Swathi-Rao Narayanagari, Ping Chi, Eduardo Vilar, Aristotelis Tsirigos and Evripidis Gavathiotis. https://www.nature.com/articles/s41467-022-28741-7
Pharmacologic Reduction of Mitochondrial Iron Triggers a Noncanonical BAX/BAK-Dependent Cell Death – Sylvain Garciaz, Andrew A. Guirguis, Sebastian Müller, Fiona C. Brown, Yih-Chih Chan, Ali Motazedian, Caitlin L. Rowe, James A. Kuzich, Kah Lok Chan, Kevin Tran, Lorey Smith, Laura MacPherson, Brian Liddicoat, Enid Y.N. Lam, Tatiana Cañeque, Marian L. Burr, Véronique Litalien, Giovanna Pomilio, Mathilde Poplineau, Estelle Duprez, Sarah-Jane Dawson, Georg Ramm, Andrew G. Cox, Kristin K. Brown, David C.S. Huang, Andrew H. Wei, Kate McArthur, Raphaël Rodriguez, Mark A. Dawson. https://aacrjournals.org/cancerdiscovery/article/12/3/774/681925
Potent, p53-independent induction of NOXA sensitizes MLL-rearranged B-cell acute lymphoblastic leukemia cells to venetoclax – Klaudyna Fidyt, Agata Pastorczak, Julia Cyran, Nicholas T. Crump, Agnieszka Goral, Joanna Madzio, Angelika Muchowicz, Martyna Poprzeczko, Krzysztof Domka, Lukasz Komorowski, Magdalena Winiarska, Joe R. Harman, Karolina Siudakowska, Agnieszka Graczyk-Jarzynka, Elzbieta Patkowska, Ewa Lech-Maranda, Wojciech Mlynarski, Jakub Golab, Thomas A. Milne and Malgorzata Firczuk. https://www.nature.com/articles/s41388-022-02196-y
Overcoming acquired resistance to third-generation EGFR inhibitors by targeting activation of intrinsic apoptotic pathway through Mcl-1 inhibition, Bax activation, or both – Guangzhi Ma, Yunfu Deng, Luxi Qian, Karin A. Vallega, Guojing Zhang, Xingming Deng, Taofeek K. Owonikoko, Suresh S. Ramalingam, Douglas D. Fang, Yifan Zhai and Shi-Yong Sun. https://www.nature.com/articles/s41388-022-02200-5
Targeting mitochondrial respiration and the BCL2 family in high‐grade MYC‐associated B‐cell lymphoma – Giulio Donati, Micol Ravà, Marco Filipuzzi, Paola Nicoli, Laura Cassina, Alessandro Verrecchia, Mirko Doni, Simona Rodighiero, Federica Parodi, Alessandra Boletta, Christopher P. Vellano, Joseph R. Marszalek, Giulio F. Draetta, Bruno Amati. https://febs.onlinelibrary.wiley.com/doi/full/10.1002/1878-0261.13115
Mcl‐1 and Bcl‐xL levels predict responsiveness to dual MEK/Bcl‐2 inhibition in B‐cell malignancies – Katrine Melvold, Mariaserena Giliberto, Linda Karlsen, Pilar Ayuda-Durán, Robert Hanes, Toril Holien, Jorrit Enserink, Jennifer R. Brown, Geir E. Tjønnfjord, Kjetil Taskén, Sigrid S. Skånland. https://febs.onlinelibrary.wiley.com/doi/full/10.1002/1878-0261.13153
CRISPR activation screen identifies BCL-2 proteins and B3GNT2 as drivers of cancer resistance to T cell-mediated cytotoxicity – Julia Joung, Paul C. Kirchgatterer, Ankita Singh, Jang H. Cho, Suchita P. Nety, Rebecca C. Larson, Rhiannon K. Macrae, Rebecca Deasy, Yuen-Yi Tseng, Marcela V. Maus and Feng Zhang. https://www.nature.com/articles/s41467-022-29205-8
Death receptors
Potent pro-apoptotic combination therapy is highly effective in a broad range of cancers – Antonella Montinaro, Itziar Areso Zubiaur, Julia Saggau, Anna-Laura Kretz, Rute M. M. Ferreira, Omar Hassan, Ella Kitzig, Ines Müller, Mona A. El-Bahrawy, Silvia von Karstedt, Dagmar Kulms, Gianmaria Liccardi, Johannes Lemke and Henning Walczak. https://www.nature.com/articles/s41418-021-00869-x
Bacterial inhibition of Fas-mediated killing promotes neuroinvasion and persistence – Claire Maudet, Marouane Kheloufi, Sylvain Levallois, Julien Gaillard, Lei Huang, Charlotte Gaultier, Yu-Huan Tsai, Olivier Disson and Marc Lecuit. https://www.nature.com/articles/s41586-022-04505-7
Interferon-γ primes macrophages for pathogen ligand-induced killing via a caspase-8 and mitochondrial cell death pathway – Daniel S. Simpson, Jiyi Pang, Ashley Weir, Isabella Y. Kong, Melanie Fritsch, Maryam Rashidi, James P. Cooney, Kathryn C. Davidson, Mary Speir, Tirta M. Djajawi, Sebastian Hughes, Liana Mackiewicz, Merle Dayton, Holly Anderton, Marcel Doerflinger, Yexuan Deng, Allan Shuai Huang, Stephanie A. Conos, Hazel Tye, Seong H. Chow, Arfatur Rahman, Raymond S. Norton, Thomas Naderer, Sandra E. Nicholson, Gaetan Burgio, Si Ming Man, Joanna R. Groom, Marco J. Herold, Edwin D. Hawkins, Kate E. Lawlor, Andreas Strasser, John Silke, Marc Pellegrini, Hamid Kashkar, Rebecca Feltham, James E. Vince. https://www.cell.com/immunity/fulltext/S1074-7613(22)00032-2
Engineering adoptive T cell therapy to co-opt Fas ligand-mediated death signaling in ovarian cancer enhances therapeutic efficacy – Kristin G Anderson, Shannon K Oda, Breanna M Bates, Madison G Burnett, Magdalia Rodgers Suarez, Susan L Ruskin and Philip D Greenberg. https://jitc.bmj.com/content/10/3/e003959
Cancer cell-intrinsic resistance to BiTE therapy is mediated by loss of CD58 costimulation and modulation of the extrinsic apoptotic pathway – Ye Shen, Jason S Eng, Flordeliza Fajardo, Lingming Liang, Cong Li, Patrick Collins, Donato Tedesco and Olivier Nolan-Stevaux. https://jitc.bmj.com/content/10/3/e004348
Caspases / IAPs
Caspase-8 has dual roles in regulatory T cell homeostasis balancing immunity to infection and collateral inflammatory damage – Charis E. Teh, Simon P. Preston, Alissa K. Robbins, Michael D. Stutz, James Cooney, Michelle P. Clark, Antonia N. Policheni, Cody C. Allison, Liana Mackiewicz, Philip Arandjelovic, Gregor Ebert, Marcel Doerflinger, Tania Tan, Lucille C. Rankin, Peggy P. Teh, Gabrielle T. Belz, Axel Kallies, Andreas Strasser, Marc Pellegrini, Daniel H. D. Gray. https://www.science.org/doi/abs/10.1126/sciimmunol.abn8041
Survivin is essential for thermogenic program and metabolic homeostasis in mice – Miriayi Alimujiang, Jingjing Sun, Shuqing Chen, Ningning Bai, Shuqin Chen, Fan Hu, Jingyuan Ma, Yuejie Xu, Jun Xu, Xiaojing Ma, Ying Yang. https://www.sciencedirect.com/science/article/pii/S2212877822000151
Therapeutic potential of Nlrp1 inflammasome, Caspase-1, or Caspase-6 against Alzheimer disease cognitive impairment – Joseph Flores, Anastasia Noël, Marie-Lyne Fillion and Andréa C. LeBlanc. https://www.nature.com/articles/s41418-021-00881-1
Pyroptosis
Fracture healing is delayed in the absence of gasdermin-interleukin-1 signaling – Kai Sun, Chun Wang, Jianqiu Xiao, Michael D Brodt, Luorongxin Yuan, Tong Yang, Yael Alippe, Huimin Hu, Dingjun Hao, Yousef Abu-Amer, Matthew J Silva, Jie Shen, Gabriel Mbalaviele . https://elifesciences.org/articles/75753
Ferroptosis
Kynurenine importation by SLC7A11 propagates anti-ferroptotic signaling – Alessandra Fiore, Leonie Zeitler, Marion Russier, Annette Groß, Maria-Kathrin Hiller, Joanne L. Parker, Luca Stier, Thomas Köcher, Simon Newstead, Peter J. Murray. https://www.cell.com/molecular-cell/fulltext/S1097-2765(22)00112-5
Ferroptosis induces membrane blebbing in placental trophoblasts – Kazuhiro Kajiwara, Ofer Beharier, Choon-Peng Chng, Julie P. Goff, Yingshi Ouyang, laudette M. St Croix, Changjin Huang, Valerian E. Kagan, K. Jimmy Hsia, Yoel Sadovsky. https://journals.biologists.com/jcs/article/135/5/jcs255737/224124/
Efferocytosis, immunogenicity
Live cell tracking of macrophage efferocytosis during Drosophila embryo development in vivo – Michael H. Raymond, Andrew J. Davidson, Yi Shen, Daniel R. Tudor, Christopher D. Lucas, Sho Morioka, Justin S. A. Perry, Julia Krapivkina, David Perrais, Linus J. Schumacher, Robert E. Campbell, Will Wood, Kodi S. Ravichandran. https://www.science.org/doi/abs/10.1126/science.abl4430
Cell death-induced immunogenicity enhances chemoimmunotherapeutic response by converting immune-excluded into T-cell inflamed bladder tumors – Fotis Nikolos, Kazukuni Hayashi, Xen Ping Hoi, Mark Ellie Alonzo, Qianxing Mo, Armine Kasabyan, Hideki Furuya, Jane Trepel, Dolores Di Vizio, Jlenia Guarnerio, Dan Theodorescu, Charles Rosser, Andrea Apolo, Matthew Galsky and Keith Syson Chan. https://www.nature.com/articles/s41467-022-29026-9
Phagoptosis
Knockout of the P2Y6 Receptor Prevents Peri-Infarct Neuronal Loss after Transient, Focal Ischemia in Mouse Brain – Stefan Milde and Guy C. Brown. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8879728/
Distinct roles in phagocytosis of the early and late increases of cell surface calreticulin induced by oxaliplatin – Kenju Matsusaka, Yutaro Azuma, Yuki Kaga, Saeka Uchida, Yuri Takebayashi, Takashi Tsuyama, Shusuke Tada. https://www.sciencedirect.com/science/article/pii/S2405580822000231
Phagocytosis and self-destruction break down dendrites of Drosophila sensory neurons at distinct steps of Wallerian degeneration – Hui Ji, Maria L Sapar, Ankita Sarkar, Bei Wang, Chun Han. https://www.pnas.org/doi/10.1073/pnas.2111818119
Miscellanous
Confined migration promotes cancer metastasis through resistance to anoikis and increased invasiveness – Deborah Fanfone, Zhichong Wu, Jade Mammi, Kevin Berthenet, David Neves, Kathrin Weber, Andrea Halaburkova, François Virard, Félix Bunel, Catherine Jamard, Hector Hernandez-Vargas, Stephen WG Tait, Ana Hennino, Gabriel Ichim. https://elifesciences.org/articles/73150
Copper induces cell death by targeting lipoylated TCA cycle proteins – Peter Tsvetkov, Shannon Coy, Boryana Petrova, Margaret Dreishpoon, Ana Verma, Mai Abdusamad, Jordan Rossen, Lena Joesch-Cohen, Ranad Humeidi, Ryan D. Spangler, John K. Eaton, Evgeni Frenkel, Mustafa Kocak, Steven M. Corsello, Svetlana Lutsenko, Naama Kanarek, Sandro Santagata, Todd R. Golub. https://www.science.org/doi/abs/10.1126/science.abf0529
Reviews
Tumor-intrinsic and immune modulatory roles of receptor-interacting protein kinases – Justin Rucker, Francis Ka-Ming Chan. https://www.cell.com/trends/biochemical-sciences/fulltext/S0968-0004(21)00273-5
Homing in on gasdermins: How fungi regulate cell death – Niklas A. Schmacke and Veit Hornung. https://www.pnas.org/doi/10.1073/pnas.2201192119?ai=aqle&ui=c8ih&af=T
Regulation of the release of damage-associated molecular patterns from necroptotic cells – Hiroyasu Nakano, Shin Murai, Kenta Moriwaki. https://portlandpress.com/biochemj/article-abstract/479/5/677/231045
Therapeutic approaches targeting CD95L/CD95 signaling in cancer and autoimmune diseases – Vesna Risso, Elodie Lafont and Matthieu Le Gallo. https://www.nature.com/articles/s41419-022-04688-x
Neuronal Loss after Stroke Due to Microglial Phagocytosis of Stressed Neurons – Guy C. Brown. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8707068/
Comments
The case for brakes: Why restrain the size of Bax and Bak pores in outer mitochondrial membranes? – David W. Andrews. https://www.cell.com/molecular-cell/fulltext/S1097-2765(22)00160-5
Copper-induced cell death – Martha A. Kahlson and Scott J. Dixon. https://www.science.org/doi/abs/10.1126/science.abo3959
Gordon Research Conference Cell Death.
Chair: Francis Chan. Vice Chair, Pascal Meier
Les Diablerets, Switzerland, May 15-20 2022. Application deadline April 22.
https://www.grc.org/cell-death-conference/2022
EWCD is ON this year in Fiuggi, Italy!
Join us from June 26th – July 1st, 2022.
Abstract submission is open until April 8th but don’t wait, do it now 🙂 www.ewcd.eu
Looking forward to seeing faces again after 4 years!
Apoptosis and cell death 