ApoList – February 2022


Caspases and cFLIP


Executioner caspases 3 and 7 are dispensable for intestinal epithelium turnover and homeostasis at steady state – Farzaneh Ghazavi, Jelle Huysentruyt, Jordy De Coninck, Stephanie Kourula, Sofie Martens, Behrouz Hassannia, Tim Wartewig, Tatyana Divert, Ria Roelandt, Bastian Popper, Andreas Hiergeist, Peter Tougaard, Tom Vanden Berghe, Marie Joossens, Geert Berx, Nozomi Takahashi, Adam Wahida, and Peter Vandenabeele. https://www.pnas.org/content/119/6/e2024508119.abstract?etoc

cFLIP downregulation is an early event required for endoplasmic reticulum stress-induced apoptosis in tumor cells – Rocío Mora-Molina, Daniela Stöhr, Markus Rehm and Abelardo López-Rivas. https://www.nature.com/articles/s41419-022-04574-6

The deubiquitinase Usp27x as a novel regulator of cFIPL protein expression and sensitizer to death-receptor-induced apoptosis – Manuel Nico Dold, Xiulin Ng, Claudia Alber, Ian Edward Gentle, Georg Häcker, Arnim Weber. https://link.springer.com/article/10.1007/s10495-021-01706-9

Microfluidic deep mutational scanning of the human executioner caspases reveals differences in structure and regulation – Hridindu Roychowdury and Philip A. Romero. https://www.nature.com/articles/s41420-021-00799-0

Cell-to-cell variability in inducible Caspase9-mediated cell death – Yuan Yuan, Huixia Ren, Yanjun Li, Shanshan Qin, Xiaojing Yang and Chao Tang. https://www.nature.com/articles/s41419-021-04468-z

Blockade of caspase cascade overcomes malaria-associated acute respiratory distress syndrome in mice – Michelle K. Sercundes, Luana S. Ortolan, Viviane da Silva Julio, Leonardo M. Bella, Thatyane de Castro Quirino, Daniela Debone, Marcela S. Carneiro-Ramos, Marcelo A. Christoffolete, Joilson O. Martins, Maria Regina D’Império Lima, José M. Alvarez, Gustavo P. Amarante-Mendes, Lígia Antunes Gonçalves, Claudio R. F. Marinho and Sabrina Epiphanio. https://www.nature.com/articles/s41419-022-04582-6


Death receptors


Cell cycle progression and transmitotic apoptosis resistance promote escape from extrinsic apoptosis – Pollak N, Lindner A, Imig D, Kuritz K, Fritze JS, Decker L, Heinrich I, Stadager J, Eisler S, Allgöwer F, Scheurich P, Rehm M. https://journals.biologists.com/jcs/article/134/24/jcs258966/273757/Cell-cycle-progression-and-transmitotic-apoptosis | https://journals.biologists.com/jcs/article/134/24/jcs259602/273793/First-person-Nadine-Pollak

ER stress-induced cell death proceeds independently of the TRAIL-R2 signaling axis in pancreatic β cells – Cathrin Hagenlocher, Robin Siebert, Bruno Taschke, Senait Wieske, Angelika Hausser and Markus Rehm. https://www.nature.com/articles/s41420-022-00830-y

Focal adhesion kinase plays a dual role in TRAIL resistance and metastatic outgrowth of malignant melanoma – Greta Del Mistro, Shamala Riemann, Sebastian Schindler, Stefan Beissert, Roland E. Kontermann, Aurelien Ginolhac, Rashi Halder, Luana Presta, Lasse Sinkkonen, Thomas Sauter and Dagmar Kulms. https://www.nature.com/articles/s41419-022-04502-8


Necroptosis, RIPK


Site-specific ubiquitination of MLKL targets it to endosomes and targets Listeria and Yersinia to the lysosomes – Seongmin Yoon, Konstantin Bogdanov and David Wallach. https://www.nature.com/articles/s41418-021-00924-7

SMYD2 targets RIPK1 and restricts TNF-induced apoptosis and necroptosis to support colon tumor growth – Yu-qiang Yu, Veronika Thonn, Jay V. Patankar, Oana-Maria Thoma, Maximilian Waldner, Marta Zielinska, Li-li Bao, Miguel Gonzalez-Acera, Stefan Wallmüller, Felix B. Engel, Michael Stürzl, Markus F. Neurath, Eva Liebing and Christoph Becker. https://www.nature.com/articles/s41419-021-04483-0

Necroptosis triggers spatially restricted neutrophil-mediated vascular damage during lung ischemia reperfusion injury – Wenjun Li (et al) Ankit Bharat, and Daniel Kreisel. https://www.pnas.org/doi/10.1073/pnas.2111537119


Pyroptosis and gasdermins


Fungal gasdermin-like proteins are controlled by proteolytic cleavage – Corinne Clavé, Witold Dyrka, Elizabeth A. Turcotte, Alexandra Granger-Farbos, Léa Ibarlosa, Benoît Pinson, Russell E. Vance, Sven J. Saupe, and Asen Daskalov. https://www.pnas.org/content/119/7/e2109418119.abstract?etoc

Streptococcal pyrogenic exotoxin B cleaves GSDMA and triggers pyroptosis – Wanyan Deng, Yang Bai, Fan Deng, Youdong Pan, Shenglin Mei, Zengzhang Zheng, Rui Min, Zeyu Wu, Wu Li, Rui Miao, Zhibin Zhang, Thomas S. Kupper, Judy Lieberman and Xing Liu. https://www.nature.com/articles/s41586-021-04384-4

Electrostatic influence on IL-1 transport through the GSDMD pore – Wen Jun Xie, Shiyu Xia, Arieh Warshel, and Hao Wu. https://www.pnas.org/content/119/6/e2120287119.abstract?etoc

TRIM21 regulates pyroptotic cell death by promoting Gasdermin D oligomerization – Wenqing Gao, Yuanyuan Li, Xuehe Liu, Sen Wang, Pucheng Mei, Zijun Chen, Kewei Liu, Suhua Li, Xue-Wei Xu, Jianhua Gan, Jiaxue Wu, Chaoneng Ji, Chen Ding, Xing Liu, Yuping Lai, Housheng Hansen He, Judy Lieberman, Hao Wu, Xiangjun Chen and Jixi Li. https://www.nature.com/articles/s41418-021-00867-z

Epithelial Gasdermin D shapes the host-microbial interface by driving mucus layer formation – Jian Zhang, Qianzhou Yu, Danlu Jiang, Kang Yu, Weiwei Yu, Zhexu Chi, Sheng Chen, Mobai Li, Dehang Yang, Zhen Wang, Ting Xu, Xingchen Guo, Kailian Zhang, Hui Fang, Qizhen Ye, Yong He, Xue Zhang, Di Wang. https://www.science.org/doi/full/10.1126/sciimmunol.abk2092


Bcl-2 family proteins


Pediatric multicellular tumor spheroid models illustrate a therapeutic potential by combining BH3 mimetics with Natural Killer (NK) cell-based immunotherapy – Vinzenz Särchen, Senthan Shanmugalingam, Sarah Kehr, Lisa Marie Reindl, Victoria Greze, Sara Wiedemann, Cathinka Boedicker, Maureen Jacob, Katrin Bankov, Nina Becker, Sibylle Wehner, Till M. Theilen, Steffen Gretser, Elise Gradhand, Carsten Kummerow, Evelyn Ullrich and Meike Vogler. https://www.nature.com/articles/s41420-021-00812-6

MCL1 nuclear translocation induces chemoresistance in colorectal carcinoma – Dechen Fu, Luke Pfannenstiel, Abeba Demelash, Yee Peng Phoon, Cameron Mayell, Claudia Cabrera, Caini Liu, Junjie Zhao, Josephine Dermawan, Deepa Patil, Jennifer DeVecchio, Matthew Kalady, Andrew J. Souers, Darren C. Phillips, Xiaoxia Li and Brian Gastman. https://www.nature.com/articles/s41419-021-04334-y

DDX3 interacts with USP9X and participates in deubiquitination of the anti‐apoptotic protein MCL1 – Ming-Chih Lai, Yi-Pin Chen, Ding-An Li, Jau-Song Yu, Hsin-Yuan Hung, Woan-Yuh Tarn. https://febs.onlinelibrary.wiley.com/doi/abs/10.1111/febs.16219

BCL-XL inhibition induces an FGFR4-mediated rescue response in colorectal cancer – Prashanthi Ramesh, Simone Di Franco, Lidia Atencia Taboada, Le Zhang, Annalisa Nicotra, Giorgio Stassi, Jan Paul Medema. https://www.cell.com/cell-reports/fulltext/S2211-1247(22)00095-X

Clonal hematopoiesis, myeloid disorders and BAX-mutated myelopoiesis in patients receiving venetoclax for CLL – Piers Blombery, Thomas E. Lew, Michael A. Dengler, Ella R. Thompson, Victor S. Lin, Xiangting Chen, Tamia Nguyen, Ashish Panigrahi, Sasanka M. Handunnetti, Dennis A. Carney, David A. Westerman, Constantine S. Tam, Jerry M. Adams, Andrew H. Wei, David C. S. Huang, John F. Seymour, Andrew W. Roberts, Mary Ann Anderson. https://ashpublications.org/blood/article-abstract/139/8/1198/476749

The BCL-2 family member BOK promotes KRAS-driven lung cancer progression in a p53-dependent manner – Anna-Lena Meinhardt, Enkhtsetseg Munkhbaatar, Ulrike Höckendorf, Michelle Dietzen, Marta Dechant, Martina Anton, Anne Jacob, Katja Steiger, Wilko Weichert, Luka Brcic, Nicholas McGranahan, Caterina Branca, Thomas Kaufmann, Michael A. Dengler and Philipp J. Jost. https://www.nature.com/articles/s41388-021-02161-1

Non-canonical phosphorylation of Bmf by p38 MAPK promotes its apoptotic activity in anoikis – Zhe Zhi, Zhenlin Ouyang, Yibo Ren, Ying Cheng, Peijun Liu, Yurong Wen and Yongping Shao. https://www.nature.com/articles/s41418-021-00855-3

NOXA expression drives synthetic lethality to RUNX1 inhibition in pancreatic cancer – Josefina Doffo, Stefanos A. Bamopoulos (et al) and Matthias Wirth. https://www.pnas.org/doi/10.1073/pnas.2105691119


Ferroptosis


Targeting ferroptosis protects against experimental (multi)organ dysfunction and death – Samya Van Coillie, Emily Van San, Ines Goetschalckx, Bartosz Wiernicki, Banibrata Mukhopadhyay, Wulf Tonnus, Sze Men Choi, Ria Roelandt, Catalina Dumitrascu, Ludwig Lamberts, Geert Dams, Wannes Weyts, Jelle Huysentruyt, Behrouz Hassannia, Irina Ingold, Suhas Lele, Evelyne Meyer, Maya Berg, Ruth Seurinck, Yvan Saeys, An Vermeulen, Alexander L. N. van Nuijs, Marcus Conrad, Andreas Linkermann, Mohan Rajapurkar, Peter Vandenabeele, Eric Hoste, Koen Augustyns and Tom Vanden Berghe. https://www.nature.com/articles/s41467-022-28718-6

C-ferroptosis is an iron-dependent form of regulated cell death in cyanobacteria – Anabella Aguilera, Federico Berdun, Carlos Bartoli, Charlotte Steelheart, Matías Alegre, Hülya Bayir, Yulia Y. Tyurina, Valerian E. Kagan, Graciela Salerno, Gabriela Pagnussat, María Victoria Martin. https://rupress.org/jcb/article-abstract/221/2/e201911005/212878


Efferocytosis, entosis etc


Tumour cell apoptosis modulates the colorectal cancer immune microenvironment via interleukin-8-dependent neutrophil recruitment – Vanessa Schimek, Katharina Strasser, Andrea Beer, Samantha Göber, Natalie Walterskirchen, Christine Brostjan, Catharina Müller, Thomas Bachleitner-Hofmann, Michael Bergmann, Helmut Dolznig and Rudolf Oehler. https://www.nature.com/articles/s41419-022-04585-3

Autolysosomes and caspase-3 control the biogenesis and release of immunogenic apoptotic exosomes – Déborah Beillevaire, Francis Migneault, Julie Turgeon, Diane Gingras, Annie Karakeussian Rimbaud, Geneviève Marcoux, Crysta Spino, Nicolas Thibodeau, Eric Bonneil, Pierre Thibault, Éric Boilard, Mélanie Dieudé and Marie-Josée Hébert. https://www.nature.com/articles/s41419-022-04591-5

Necrotic debris and STING exert therapeutically relevant effects on tumor cholesterol homeostasis – Sampath Katakam, ProfileSantosh Anand, Patricia Martin, ProfileNicolo Riggi, ProfileIvan Stamenkovic. https://www.life-science-alliance.org/content/5/3/e202101256.abstract?etoc


Miscellanous


Functional visualization of NK cell-mediated killing of metastatic single tumor cells – Hiroshi Ichise, Shoko Tsukamoto, Tsuyoshi Hirashima, Yoshinobu Konishi, Choji Oki, Shinya Tsukiji, Satoshi Iwano, Atsushi Miyawaki, Kenta Sumiyama, Kenta Terai, Michiyuki Matsuda. https://elifesciences.org/articles/76269


Reviews


Regulation of extrinsic apoptotic signaling by c-FLIP: towards targeting cancer networks – Nikita V. Ivanisenko, Kamil Seyrek, Laura K. Hillert-Richter, Corinna König, Johannes Espe, Kakoli Bose, Inna N. Lavrik. https://www.cell.com/trends/cancer/fulltext/S2405-8033(21)00250-8

The concept of intrinsic versus extrinsic apoptosis – Laura Lossi. https://portlandpress.com/biochemj/article-abstract/479/3/357/230785

Double-edge sword roles of iron in driving energy production versus instigating ferroptosis – Shuping Zhang, Wei Xin, Gregory J. Anderson, Ruibin Li, Ling Gao, Shuguang Chen, Jiajun Zhao and Sijin Liu. https://www.nature.com/articles/s41419-021-04490-1

Collective effects in epithelial cell death and cell extrusion – Alexis Villars, Romain Levayer. https://www.sciencedirect.com/science/article/abs/pii/S0959437X21001106

Cell competition in vertebrates — a key machinery for tissue homeostasis – Takeshi Maruyama, Yasuyuki Fujita. https://www.sciencedirect.com/science/article/abs/pii/S0959437X2100118

Special issue Biochimica et Biophysica Acta (BBA) – Molecular Cell Research: “Death mechanisms in cellular homeostasis” Edited by Prof. Peter Ruvolo, Prof. Geert Bultynck. https://www.sciencedirect.com/journal/biochimica-et-biophysica-acta-bba-molecular-cell-research/special-issue/107S1CX8XZZ

Including, among others:

  • Cancer cell death strategies by targeting Bcl-2’s BH4 domain – Ian de Ridder, Martijn Kerkhofs, Santhini Pulikkal Veettil, Wim Dehaen, Geert Bultynck
  • It’s time to die: BH3 mimetics in solid tumors – Sarah Kehr, Meike Vogler
  • Death sentence: The tale of a fallen endoplasmic reticulum – Eoghan P. McGrath, Federica G. Centonze, Eric Chevet, Tony Avril, Elodie Lafont
  • Targeting epigenetic mechanisms to overcome venetoclax resistance – Gabriel Prado, Charlotte L. Kaestner, Jonathan D. Licht, Richard L. Bennett
  • Cell death as a result of calcium signaling modulation: A cancer-centric prospective – Alberto Danese, Sara Leo, Alessandro Rimessi, Mariusz R. Wieckowski, … Paolo Pinton

Persister cancer cells: Iron addiction and vulnerability to ferroptosis – Raphaël Rodriguez, Stuart L. Schreiber, Marcus Conrad. https://www.cell.com/molecular-cell/fulltext/S1097-2765(21)01038-8

Pyroptosis, a target for cancer treatment? – Ying Huang, Jian-Wei Wang, Jiao Huang, Lu Tang, Yun-Hua Xu, Hong Sun, Jie Tang, Guo Wang. https://link.springer.com/article/10.1007/s10495-021-01703-y


Comments


MLKL ubiquitylation: more than a makeover – Weihong Wang and Yi-Nan Gong. https://www.nature.com/articles/s41418-022-00934-z

A BAX door to venetoclax resistance – Franco Izzo, Dan A. Landau. https://ashpublications.org/blood/article/139/8/1124/484077/A-BAX-door-to-venetoclax-resistance

A lncRNA builds a glycolytic metabolon – Kim Baumann. https://www.nature.com/articles/s41580-022-00461-2


Conference:

EMBO Workshop “Dying in self-defense: cell death signaling in animals and plants”

Organized by Ana García and Panagiotis Moschou

1st – 5th May 2022 – Kalimera Kriti Hotel & Village Resort, Crete, Greece

https://meetings.embo.org/event/21-cell-death

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