ApoList – January 2022


Bcl-2 family proteins


BCL‐2‐family protein tBID can act as a BAX‐like effector of apoptosis – Hector Flores-Romero, Lisa Hohorst, Malina John, Marie-Christine Albert, Louise E King, Laura Beckmann, Tamas Szabo, Vanessa Hertlein, Xu Luo, Andreas Villunger, Lukas P Frenzel, Hamid Kashkar, Ana J Garcia-Saez. https://www.embopress.org/doi/full/10.15252/embj.2021108690

Structural basis of BAK activation in mitochondrial apoptosis initiation – Geetika Singh, Cristina D. Guibao and Tudor Moldoveanu. https://www.nature.com/articles/s41467-021-27851-y

Targeting Cpt1a-Bcl-2 interaction modulates apoptosis resistance and fibrotic remodeling – Linlin Gu, Ranu Surolia, Jennifer L. Larson-Casey, Chao He, Dana Davis, Jungsoon Kang, Veena B. Antony and A. Brent Carter. https://www.nature.com/articles/s41418-021-00840-w

The BCL-2 family member BOK promotes KRAS-driven lung cancer progression in a p53-dependent manner – Anna-Lena Meinhardt, Enkhtsetseg Munkhbaatar, Ulrike Höckendorf, Michelle Dietzen, Marta Dechant, Martina Anton, Anne Jacob, Katja Steiger, Wilko Weichert, Luka Brcic, Nicholas McGranahan, Caterina Branca, Thomas Kaufmann, Michael A. Dengler and Philipp J. Jost. https://www.nature.com/articles/s41388-021-02161-1


Efferocytosis, tissue homeostasis


Sensing plasma membrane pore formation induces chemokine production in survivors of regulated necrosis – Weihong Wang, Joshua S. Prokopec, Yixin Zhang, Maria Sukhoplyasova, Himaly Shinglot, Man-Tzu Wang, Andreas Linkermann, Jacob Stewart-Ornstein, Yi-Nan Gong. https://www.cell.com/developmental-cell/fulltext/S1534-5807(21)01035-2

Polyamine import and accumulation causes immunomodulation in macrophages engulfing apoptotic cells – Alexandra L. McCubbrey, Shannon A. McManus, Jazalle D. McClendon, Stacey M. Thomas, Hope B. Chatwin, Julie A. Reisz, Angelo D’Alessandro, Kara J. Mould, Donna L. Bratton, Peter M. Henson, William J. Janssen. https://www.cell.com/cell-reports/fulltext/S2211-1247(21)01726-5

Rapid lamellipodial responses by neighbor cells drive epithelial sealing in response to pyroptotic cell death – Alexis Bonfim-Melo, Ivar Noordstra, Shafali Gupta, Amy H. Chan, Mathew J.K. Jones, Kate Schroder, Alpha S. Yap. https://www.cell.com/cell-reports/fulltext/S2211-1247(22)00027-4


Caspases and IAPs


Drice restrains Diap2-mediated inflammatory signalling and intestinal inflammation – Christa Kietz, Aravind K. Mohan, Vilma Pollari, Ida-Emma Tuominen, Paulo S. Ribeiro, Pascal Meier and Annika Meinander. https://www.nature.com/articles/s41418-021-00832-w


Death receptors, necroptosis


Targeting necroptosis in muscle fibers ameliorates inflammatory myopathies – Mari Kamiya, Fumitaka Mizoguchi, Kimito Kawahata, Dengli Wang, Masahiro Nishibori, Jessica Day, Cynthia Louis, Ian P. Wicks, Hitoshi Kohsaka and Shinsuke Yasuda. https://www.nature.com/articles/s41467-021-27875-4


Pyroptosis


Bacterial gasdermins reveal an ancient mechanism of cell death – Alex G. Johnson, Tanita Wein, Megan L. Mayer, Brianna Duncan-Lowey, Erez Yirmiya, Yaara Oppenheimer-Shaanan, Gil Amitai, Rotem Sorek, Philip J. Kranzusch. https://www.science.org/doi/abs/10.1126/science.abj8432

GSDMB is increased in IBD and regulates epithelial restitution/repair independent of pyroptosis – Nitish Rana, Giuseppe Privitera, Hannah C. Kondolf, Katarzyna Bulek, Susana Lechuga, Carlo De Salvo, Daniele Corridoni, Agne Antanaviciute, Rebecca L. Maywald, Alexander M. Hurtado, Junjie Zhao, Emina H. Huang, Xiaoxia Li, E. Ricky Chan, Alison Simmons, Giorgos Bamias, Derek W. Abbott, Jason D. Heaney, Andrei I. Ivanov, Theresa T. Pizarro. https://www.cell.com/cell/fulltext/S0092-8674(21)01487-2

Gasdermin D pores are dynamically regulated by local phosphoinositide circuitry – Ana Beatriz Santa Cruz Garcia, Kevin P. Schnur and Gary C. H. Mo. https://www.nature.com/articles/s41467-021-27692-9

Streptococcal pyrogenic exotoxin B cleaves GSDMA and triggers pyroptosis – Wanyan Deng, Yang Bai, Fan Deng, Youdong Pan, Shenglin Mei, Zengzhang Zheng, Rui Min, Zeyu Wu, Wu Li, Rui Miao, Zhibin Zhang, Thomas S. Kupper, Judy Lieberman and Xing Liu. https://www.nature.com/articles/s41586-021-04384-4


Ferroptosis


Dexamethasone Sensitizes to Ferroptosis by Glucocorticoid Receptor-induced Dipeptidase-1 expression and Glutathione Depletion – von Mässenhausen A, Zamora Gonzalez N, Maremonti F, Belavgeni A, Tonnus W, Meyer C, Beer K, Hannani MT, Lau A, Peitzsch M, Hoppenz P, Locke S, Chavakis T, Kramann R, Muruve DA, Hugo C, Bornstein SR, Linkermann A. https://www.science.org/doi/10.1126/sciadv.abl8920

PKCβII phosphorylates ACSL4 to amplify lipid peroxidation to induce ferroptosis – Hai-Liang Zhang, Bing-Xin Hu, Zhi-Ling Li, Tian Du, Jia-Lu Shan, Zhi-Peng Ye, Xiao-Dan Peng, Xuan Li, Yun Huang, Xian-Ying Zhu, Yu-Hong Chen, Gong-Kan Feng, Dajun Yang, Rong Deng and Xiao-Feng Zhu. https://www.nature.com/articles/s41556-021-00818-3


Miscellanous


Senescence induction dictates response to chemo- and immunotherapy in preclinical models of ovarian cancer – Stella V. Paffenholz, Camilla Salvagno, Yu-Jui Ho, Matthew Limjoco, Timour Baslan, Sha Tian, Amanda Kulick, Elisa de Stanchina, John E. Wilkinson, Francisco M. Barriga, Dmitriy Zamarin, Juan R. Cubillos-Ruiz, Josef Leibold, and Scott W. Lowe. https://www.pnas.org/content/119/5/e2117754119.abstract?etoc

Bacillus anthracis induces NLRP3 inflammasome activation and caspase-8–mediated apoptosis of macrophages to promote lethal anthrax – Filip Van Hauwermeiren, Nina Van Opdenbosch, Hanne Van Gorp, Nathalia de Vasconcelos, Geert van Loo, Peter Vandenabeele, Thirumala-Devi Kanneganti, and Mohamed Lamkanfi. https://www.pnas.org/content/119/2/e2116415119.abstract


Reviews/comments


The complex interplay between autophagy and cell death pathways – Christina Ploumi, Margarita-Elena Papandreou, Nektarios Tavernarakis. https://portlandpress.com/biochemj/article-abstract/479/1/75/230651

The role of Ubiquitination in Apoptosis and Necroptosis – Jamie Z. Roberts, Nyree Crawford and Daniel B. Longley. https://www.nature.com/articles/s41418-021-00922-9

Cellular senescence: all roads lead to mitochondria – Hélène Martini, João F. Passos. https://febs.onlinelibrary.wiley.com/doi/full/10.1111/febs.16361#.Yfhngl2bq4U

Positive feedback amplifies ferroptosis – Jason Rodencal & Scott J. Dixon. https://www.nature.com/articles/s41556-021-00824-5

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