ApoList – December 2021

Bcl-2 family proteins

The BH3-only protein NOXA serves as an independent predictor of breast cancer patient survival and defines susceptibility to microtubule targeting agents – Gerlinde Karbon, Manuel D. Haschka, Hubert Hackl, Claudia Soratroi, Lourdes Rocamora-Reverte, Walther Parson, Heidelinde Fiegl and Andreas Villunger. https://www.nature.com/articles/s41419-021-04415-y

Oligodendrocytes depend on MCL-1 to prevent spontaneous apoptosis and white matter degeneration – Abigail H. Cleveland, Alejandra Romero-Morales, Laurent Alfonso Azcona, Melisa Herrero, Viktoriya D. Nikolova, Sheryl Moy, Orna Elroy-Stein, Vivian Gama and Timothy R. Gershon. https://www.nature.com/articles/s41419-021-04422-z

Death receptors

Bclaf1 regulates c-FLIP expression and protects cells from TNF-induced apoptosis and tissue injury – Rui Zhang, Teng Xue, Anwen Shao, Yue Lang, Chao Qin, Mingliang Zhao, Yu Kuang, Zhengquan Yu, Yunyun Geng, Chenyang Zhao, Jun Tang. https://www.embopress.org/doi/abs/10.15252/embr.202152702

Immune dysregulation in SHARPIN-deficient mice is dependent on CYLD-mediated cell death – Rosalind L. Ang, Mark Chan, Diana Legarda, John P. Sundberg, Shao-Cong Sun, Virginia L. Gillespie, Nicholas Chun, Peter S. Heeger, Huabao Xiong, Sergio A. Lira, and Adrian T. Ting. https://www.pnas.org/content/118/50/e2001602118.abstract?etoc


Suppression of caspase 8 activity by a coronin 1–PI3Kδ pathway promotes T cell survival independently of TCR and IL-7 signaling – Mayumi Mori, Julie Ruer-Laventie, Wandrille Duchemin, Philippe Demougin, Tohnyui Ndinyanka Fabrice, Matthias P. Wymann, Jean Pieters. https://www.science.org/doi/abs/10.1126/scisignal.abj0057

Necroptosis / RIPK1

The role of RIPK1 mediated cell death in acute on chronic liver failure – Takayuki Kondo, Stewart Macdonald, Cornelius Engelmann, Abeba Habtesion, Jane Macnaughtan, Gautam Mehta, Rajeshwar P. Mookerjee, Nathan Davies, Marco Pavesi, Richard Moreau, Paolo Angeli, Vicente Arroyo, Fausto Andreola and Rajiv Jalan. https://www.nature.com/articles/s41419-021-04442-9

TNF-induced necroptosis initiates early autophagy events via RIPK3-dependent AMPK activation, but inhibits late autophagy – Wenxian Wu, Xiaojing Wang, Yadong Sun, Niklas Berleth, Jana Deitersen, David Schlütermann, Fabian Stuhldreier, Nora Wallot-Hieke, María José Mendiburo, Jan Cox, Christoph Peter, Ann Kathrin Bergmann and Björn Stork. https://www.tandfonline.com/doi/abs/10.1080/15548627.2021.1898748

RIPK1 dephosphorylation and kinase activation by PPP1R3G/PP1γ promote apoptosis and necroptosis – Jingchun Du, Yougui Xiang, Hua Liu, Shuzhen Liu, Ashwani Kumar, Chao Xing, Zhigao Wang. https://www.nature.com/articles/s41467-021-27367-5


Identification of an ASC oligomerization inhibitor for the treatment of inflammatory diseases – Paula M. Soriano-Teruel, Guillermo García‑Laínez, María Marco-Salvador, Julián Pardo, Maykel Arias, Christian DeFord, Irmgard Merfort, María J. Vicent, Pablo Pelegrín, Mónica Sancho and Mar Orzáez. https://www.nature.com/articles/s41419-021-04420-1

Strategies to package recombinant Adeno-Associated Virus expressing the N-terminal gasdermin domain for tumor treatment – Yuan Lu, Wenbo He and Gang Cao. https://www.nature.com/articles/s41467-021-27407-0

Efferocytosis, entosis, phagoptosis

Efferocytosis induces macrophage proliferation to help resolve tissue injury – Brennan D. Gerlach, Patrick B. Ampomah, Arif Yurdagul Jr., Chuang Liu, Max C. Lauring, Xiaobo Wang, Canan Kasikara, Na Kong, Jinjun Shi, Wei Tao, Ira Tabas. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(21)00527-1

The microglial P2Y6 receptor mediates neuronal loss and memory deficits in neurodegeneration – Puigdellívol M, Milde S, Vilalta A, Cockram TOJ, Allendorf DH, Lee JY, Dundee JM, Pampuščenko K, Borutaite V, Nuthall HN, Brelstaff JH, Spillantini MG, Brown GC. https://www.sciencedirect.com/science/article/pii/S2211124721016442

Inflammatory neuronal loss in the substantia nigra induced by systemic lipopolysaccharide is prevented by knockout of the P2Y6 receptor in mice – Milde S, van Tartwijk FW, Vilalta A, Hornik TC, Dundee JM, Puigdellívol M, Brown GC. https://jneuroinflammation.biomedcentral.com/articles/10.1186/s12974-021-02280-2


Identification of the BCL2/adenovirus E1B-19K protein-interacting protein 2 (BNIP-2) as a granzyme B target during human natural killer cell-mediated killing – Gina B. Scott, Paul A. Bowles, Erica B. Wilson, Josephine L. Meade, Boon Chuan Low, Adam Davison, G. Eric Blair, Graham P. Cook. https://portlandpress.com/biochemj/article-abstract/431/3/423/45170


The evolution of regulated cell death pathways in animals and their evasion by pathogens – Bart Tummers, Douglas R Green. https://journals.physiology.org/doi/abs/10.1152/physrev.00002.2021

The manipulation of apoptosis for cancer therapy using BH3-mimetic drugs – Sarah T. Diepstraten, Mary Ann Anderson, Peter E. Czabotar, Guillaume Lessene, Andreas Strasser and Gemma L. Kelly. https://www.nature.com/articles/s41568-021-00407-4

Impact of human CD95 mutations on cell death and autoimmunity: a model – Kamil Seyrek, Nikita V. Ivanisenko, Fabian Wohlfromm, Johannes Espe, Inna N. Lavrik. https://www.cell.com/trends/immunology/fulltext/S1471-4906(21)00242-8

Physiological and pharmacological modulation of BAX – Adam Z. Spitz, Evripidis Gavathiotis. https://www.cell.com/trends/pharmacological-sciences/fulltext/S0165-6147(21)00216-9

The role of caspases as executioners of apoptosis – Sharad Kumar, Loretta Dorstyn, Yoon Lim. https://portlandpress.com/biochemsoctrans/article/doi/10.1042/BST20210751/230566

Immunogenic ferroptosis and where to find it? – Robin Demuynck, Iuliia Efimova, Faye Naessens and Dmitri V Krysko. https://jitc.bmj.com/content/9/12/e003430

Necroptosis and tumor progression – Jiong Yan, Peixing Wan, Swati Choksi, Zheng-Gang Liu. https://www.cell.com/trends/cancer/fulltext/S2405-8033(21)00193-X

Killing by Degradation: Regulation of Apoptosis by the Ubiquitin-Proteasome-System – Ruqaia Abbas and Sarit Larisch. https://www.mdpi.com/2073-4409/10/12/3465

I’m Infected, Eat Me! Innate Immunity Mediated by Live, Infected Cells Signaling To Be Phagocytosed – Birkle T, Brown GC. https://journals.asm.org/doi/10.1128/IAI.00476-20

Neuronal Loss after Stroke Due to Microglial Phagocytosis of Stressed Neurons – Brown GC. https://www.mdpi.com/1422-0067/22/24/13442

The Phagocytic Code Regulating Phagocytosis of Mammalian Cells – Cockram TO, Dundee JM, Popescu AS, Brown GC. https://www.frontiersin.org/articles/10.3389/fimmu.2021.629979/full

Microglial phagocytosis of neurons in neurodegeneration, and its regulation – Butler CA, Popescu AS, Kitchener EJ, Allendorf DH, Puigdellívol M, Brown GC. https://onlinelibrary.wiley.com/doi/10.1111/jnc.15327

In conversation with Christine Watson – Paraminder Dhillon, Christine J. Watson. https://febs.onlinelibrary.wiley.com/doi/full/10.1111/febs.16071

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