Bcl-2 family proteins
Dynamic reconfiguration of pro‐apoptotic BAK on membranes – Jarrod J Sandow, Iris KL Tan, Alan S Huang, Shashank Masaldan, Jonathan P Bernardini, Ahmad Z Wardak, Richard W Birkinshaw, Robert L Ninnis, Ziyan Liu, Destiny Dalseno, Daisy Lio, Giuseppi Infusini, Peter E Czabotar, Andrew I Webb, Grant Dewson. https://www.embopress.org/doi/abs/10.15252/embj.2020107237
High‐resolution analysis of the conformational transition of pro‐apoptotic Bak at the lipid membrane – Laura E Sperl, Florian Rührnößl, Anita Schiller, Martin Haslbeck, Franz Hagn. https://www.embopress.org/doi/full/10.15252/embj.2020107159
The anti‐apoptotic Bcl‐2 protein regulates hair follicle stem cell function – Anna Geueke, Giada Mantellato, Florian Kuester, Peter Schettina, Melanie Nelles, Jens Michael Seeger, Hamid Kashkar, Catherin Niemann. https://www.embopress.org/doi/full/10.15252/embr.202052301
Genome-wide mRNA profiling identifies X-box-binding protein 1 (XBP1) as an IRE1 and PUMA repressor – Magdalena Gebert, Aleksandra Sobolewska, Sylwia Bartoszewska, Aleksandra Cabaj, David K. Crossman, Jarosław Króliczewski, Piotr Madanecki, Michał Dąbrowski, James F. Collawn and Rafal Bartoszewski. https://link.springer.com/article/10.1007%2Fs00018-021-03952-1
Fatty acid synthase (FASN) regulates the mitochondrial priming of cancer cells – Barbara Schroeder, Travis Vander Steen, Ingrid Espinoza, Chandra M. Kurapaty Venkatapoorna, Zeng Hu, Fernando Martín Silva, Kevin Regan, Elisabet Cuyàs, X. Wei Meng, Sara Verdura, Aina Arbusà, Paula A. Schneider, Karen S. Flatten, George Kemble, Joan Montero, Scott H. Kaufmann, Javier A. Menendez and Ruth Lupu. https://www.nature.com/articles/s41419-021-04262-x
MCL-1 Inhibition Overcomes Anti-apoptotic Adaptation to Targeted Therapies in B-Cell Precursor Acute Lymphoblastic Leukemia – Albert Manzano-Muñoz, Clara Alcon, Pablo Menéndez, Manuel Ramírez, Felix Seyfried, Klaus-Michael Debatin, Lüder H. Meyer, Josep Samitier and Joan Montero. https://www.frontiersin.org/articles/10.3389/fcell.2021.695225/full
Doxorubicin-induced novel circRNA_0004674 facilitates osteosarcoma progression and chemoresistance by upregulating MCL1 through miR-142-5p – Xiao-Long Ma, Tai-Cheng Zhan, Jian-Ping Hu, Chun-Lin Zhang and Kun-Peng Zhu. https://www.nature.com/articles/s41420-021-00698-4
SNAI2-Mediated Repression of BIM Protects Rhabdomyosarcoma from Ionizing Radiation – Long Wang, Nicole R. Hensch, Kathryn Bondra, Prethish Sreenivas, Xiang R. Zhao, Jiangfei Chen, Rodrigo Moreno Campos, Kunal Baxi, Angelina V. Vaseva, Benjamin D. Sunkel, Berkley E. Gryder, Silvia Pomella, Benjamin Z. Stanton, Siyuan Zheng, Eleanor Y. Chen, Rossella Rota, Javed Khan, Peter J. Houghton and Myron S. Ignatius. https://cancerres.aacrjournals.org/content/81/21/5451
Death receptors
Phosphoproteome profiling uncovers a key role for CDKs in TNF signaling – Maria C. Tanzer, Isabell Bludau, Che A. Stafford, Veit Hornung and Matthias Mann. https://www.nature.com/articles/s41467-021-26289-6
HSPA13 facilitates NF-κβ-mediated transcription and attenuates cell death responses in TNFα signaling – Chun Gao, Jianhua Deng, Hanchenxi Zhang, Xinran Li, Shuchen Gu, Mingjie Zheng, Mei Tang, Yezhang Zhu, Xin Lin, Jianping Jin, Long Zhang, Jun Huang, Jian Zou, Zong-Ping Xia, Ping-Long Xu, Li Shen, Bin Zhao, Xin-Hua Feng. https://www.science.org/doi/full/10.1126/sciadv.abh1756
FAIM regulates autophagy through glutaminolysis in lung adenocarcinoma – Tianyu Han, Pengcheng Wang, Yanan Wang, Wenze Xun, Jiapeng Lei, Tao Wang, Zhuo Lu, Mingxi Gan, Wei Zhang, Bentong Yu and Jian-Bin Wang. https://www.tandfonline.com/doi/full/10.1080/15548627.2021.1987672
Caspases, RIPK1
RIPK1 regulates starvation resistance by modulating aspartate catabolism – Xinyu Mei, Yuan Guo, Zhangdan Xie, Yedan Zhong, Xiaofen Wu, Daichao Xu, Ying Li, Nan Liu and Zheng-Jiang Zhu. https://www.nature.com/articles/s41467-021-26423-4
Environmental allergens trigger type 2 inflammation through ripoptosome activation – Michael Brusilovsky, Mark Rochman, Yrina Rochman, Julie M. Caldwell, Lydia E. Mack, Jennifer M. Felton, Jeff E. Habel, Aleksey Porollo, Chandrashekhar Pasare and Marc E. Rothenberg. https://www.nature.com/articles/s41590-021-01011-2
Necroptosis
ZBP1-MLKL necroptotic signaling potentiates radiation-induced antitumor immunity via intratumoral STING pathway activation – Yuanqin Yang, Meng Wu, Dongqing Cao, Chao Yang, Jingsi Jin, Lingling Wu, Xiaochuan Hong, Wenwen Li, Lu Lu, Jinmei Li, Xinran Wang, Xiangjiao Meng, Zhen Zhang, Jinke Cheng, Youqiong Ye, Hui Xiao, Jinming Yu, Liufu Deng. https://www.science.org/doi/full/10.1126/sciadv.abf6290
OTULIN inhibits RIPK1-mediated keratinocyte necroptosis to prevent skin inflammation in mice – Hannah Schünke, Ulrike Göbel, Ivan Dikic and Manolis Pasparakis. https://www.nature.com/articles/s41467-021-25945-1
Pyroptosis, inflammation
Shigella evades pyroptosis by arginine ADP-riboxanation of caspase-11 – Zilin Li, Wang Liu, Jiaqi Fu, Sen Cheng, Yue Xu, Zhiqiang Wang, Xiaofan Liu, Xuyan Shi, Yaxin Liu, Xiangbing Qi, Xiaoyun Liu, Jingjin Ding and Feng Shao. https://www.nature.com/articles/s41586-021-04020-1
Caspase-8 Is a Linchpin in Caspase-3 and Gasdermin D Activation to Control Cell Death, Cytokine Release, and Host Defense during Influenza A Virus Infection – Yaqiu Wang, Rajendra Karki, Min Zheng, Balabhaskararao Kancharana, SangJoon Lee, Sannula Kesavardhana, Baranda S Hansen, Shondra M Pruett-Miller, Thirumala-Devi Kanneganti.. https://www.jimmunol.org/content/early/2021/10/18/jimmunol.2100757.long
OTULIN maintains skin homeostasis by controlling keratinocyte death and stem cell identity – Esther Hoste, Kim Lecomte, Karl Annusver, Niels Vandamme, Jana Roels, Sophia Maschalidi, Lien Verboom, Hanna-Kaisa Vikkula, Mozes Sze, Lisette Van Hove, Kevin Verstaen, Arne Martens, Tino Hochepied, Yvan Saeys, Kodi Ravichandran, Maria Kasper and Geert van Loo. https://www.nature.com/articles/s41467-021-25944-2
NLRP3 inflammasome activation triggers gasdermin D-independent inflammation – Chun Wang, Tong Yang, Jianqiu Xiao, Canxin Xu, Yael Alippe, Kai Sun, Thirumala-Devi Kanneganti, Joseph B. Monahan, Yousef Abu-Amer, Judy Lieberman, Gabriel Mbalaviele. https://www.science.org/doi/abs/10.1126/sciimmunol.abj3859
Efferocytosis – inflammation
eccDNAs are apoptotic products with high innate immunostimulatory activity – Yuangao Wang, Meng Wang, Mohamed Nadhir Djekidel, Huan Chen, Di Liu, Frederick W. Alt and Yi Zhang. https://www.nature.com/articles/s41586-021-04009-w
Attenuation of apoptotic cell detection triggers thymic regeneration after damage – Sinéad Kinsella, Cindy A. Evandy, Kirsten Cooper, Lorenzo Iovino, Paul C. deRoos, Kayla S. Hopwo, David W. Granadier, Colton W. Smith, Shahin Rafii, Jarrod A. Dudakov. https://www.cell.com/cell-reports/fulltext/S2211-1247(21)01248-1
Miscellanous
Mitochondrial translation is required for sustained killing by cytotoxic T cells – Miriam Lisci, Philippa R. Barton, Lyra O. Randzavola, Claire Y. Ma, Julia M. Marchingo, Doreen A. Cantrell, Vincent Paupe, Julien Prudent, Jane C. Stinchcombe, Gillian M. Griffiths. https://www.science.org/doi/10.1126/science.abe9977
Neurotoxic reactive astrocytes induce cell death via saturated lipids – Kevin A. Guttenplan, Maya K. Weigel, Priya Prakash, Prageeth R. Wijewardhane, Philip Hasel, Uriel Rufen-Blanchette, Alexandra E. Münch, Jacob A. Blum, Jonathan Fine, Mikaela C. Neal, Kimberley D. Bruce, Aaron D. Gitler, Gaurav Chopra, Shane A. Liddelow and Ben A. Barres. https://www.nature.com/articles/s41586-021-03960-y
Lysosomal Zn2+ release triggers rapid, mitochondria-mediated, non-apoptotic cell death in metastatic melanoma – Wanlu Du, Mingxue Gu, Meiqin Hu, Prateeksunder Pinchi, Wei Chen, Michael Ryan, Timothy Nold, Ahmed Bannaga, Haoxing Xu. https://www.cell.com/cell-reports/fulltext/S2211-1247(21)01312-7
Cell death inhibitors protect against brain damage caused by cardiac ischemia/reperfusion injury – Suchan Liao, Nattayaporn Apaijai, Ying Luo, Jun Wu, Titikorn Chunchai, Kodchanan Singhanat, Busarin Arunsak, Juthipong Benjanuwattra, Nipon Chattipakorn and Siriporn C. Chattipakorn. https://www.nature.com/articles/s41420-021-00698-4
Protein Signatures of NK Cell–Mediated Melanoma Killing Predict Response to Immunotherapies – Sabrina Cappello, Hsu-Min Sung, Christian Ickes, Christine S. Gibhardt, Adina Vultur, Hilal Bhat, Zhongwen Hu, Patricia Brafford, Andreas Denger, Ioana Stejerean-Todoran, Rixa-Mareike Köhn, Verena Lorenz, Nicolas Künzel, Gabriela Salinas, Hedwig Stanisz, Tobias Legler, Peter Rehling, Michael P. Schön, Karl S. Lang, Volkhard Helms, Meenhard Herlyn, Markus Hoth, Carsten Kummerow and Ivan Bogeski. https://cancerres.aacrjournals.org/content/81/21/5540
Reviews
The multifaceted role of TRAIL signaling in cancer and immunity – Ludmila Cardoso Alves, Nadia Corazza, Olivier Micheau, Philippe Krebs. https://febs.onlinelibrary.wiley.com/doi/full/10.1111/febs.15637
Ferroptosis: machinery and regulation – Xin Chen, Jingbo Li, Rui Kang, Daniel J. Klionsky and Daolin Tang. https://www.tandfonline.com/doi/abs/10.1080/15548627.2020.1810918
Ferroptosis in liver disease: new insights into disease mechanisms – Jing Wu, Yi Wang, Rongtao Jiang, Ran Xue, Xuehong Yin, Muchen Wu and Qinghua Meng. https://www.nature.com/articles/s41420-021-00660-4
Comments
A killer metamorphosis: catching BAK in action at the membrane – Adedolapo M Ojoawo, Tudor Moldoveanu. https://www.embopress.org/doi/abs/10.15252/embj.2021109529
Glutamine gluttony of efferocytes – Alison Jaccard, Xiaoyun Li and Ping-Chih Ho. https://www.nature.com/articles/s42255-021-00462-z
Apoptosis and cell death 