ApoList – April 2021


Bcl-2 family proteins


Structural insight into the molecular mechanism of p53-mediated mitochondrial apoptosis – Hudie Wei, Lingzhi Qu, Shuyan Dai, Yun Li, Haolan Wang, Yilu Feng, Xiaojuan Chen, Longying Jiang, Ming Guo, Jun Li, Zhuchu Chen, Lin Chen, Ye Zhang and Yongheng Chen. https://www.nature.com/articles/s41467-021-22655-6

The spleen as a sanctuary site for residual leukemic cells following ABT-199 monotherapy in ETP-ALL – Alessandra Di Grande, Sofie Peirs, Paul D. Donovan, Maaike Van Trimpont, Julie Morscio, Beatrice Lintermans, Lindy Reunes, Niels Vandamme, Steven Goossens, Hien Anh Nguyen, Arnon Lavie, Richard B. Lock, Jochen H. M. Prehn, Pieter Van Vlierberghe, Triona Ní Chonghaile. https://ashpublications.org/bloodadvances/article/5/7/1963/475682

Pathological angiogenesis in retinopathy engages cellular senescence and is amenable to therapeutic elimination via BCL-xL inhibition – Sergio Crespo-Garcia, Pamela R. Tsuruda, Agnieszka Dejda, Rathi D. Ryan, Frederik Fournier, Shawnta Y. Chaney, Frederique Pilon, Taner Dogan, Gael Cagnone, Priyanka Patel, Manuel Buscarlet, Sonali Dasgupta, Gabrielle Girouard, Surabhi R. Rao, Ariel M. Wilson, Robert O’Brien, Rachel Juneau, Vera Guber, Alexandre Dubrac, Christian Beausejour, Scott Armstrong, Frederick A. Mallette, Christopher B. Yohn, Jean-Sebastien Joyal, Dan Marquess, Pedro J. Beltran, Przemyslaw Sapieha. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(21)00011-5

Identification of a novel Bax–Cdk1 signalling complex that links activation of the mitotic checkpoint to apoptosis – Omeed Darweesh, Eman Al-Shehri, Hugo Falquez, Joachim Lauterwasser, Frank Edlich, Rajnikant Patel. https://journals.biologists.com/jcs/article/134/8/jcs244152/237811


RIPK1 / death receptors


Genetic inactivation of RIP1 kinase activity in rats protects against ischemic brain injury – Kimberly Stark, Tatiana Goncharov, Eugene Varfolomeev, Luke Xie, Hai Ngu, Ivan Peng, Keith R. Anderson, Erik Verschueren, Meena Choi, Donald S. Kirkpatrick, Amy Easton, Joshua D. Webster, Brent S. McKenzie, Domagoj Vucic and Baris Bingol. https://www.nature.com/articles/s41419-021-03651-6

RIP1 kinase activity promotes steatohepatitis through mediating cell death and inflammation in macrophages – Liang Tao, Yuguo Yi, Yuxin Chen, Haibing Zhang, Pontus Orning, Egil Lien, Jiapeng Jie, Weigao Zhang, Qian Xu, Yang Li, Zhao Ding, Chao Wu, Qiurong Ding, Junsong Wang, Jianfa Zhang and Dan Weng. https://www.nature.com/articles/s41418-020-00668-w

Splicing reprogramming of TRAIL/DISC-components sensitizes lung cancer cells to TRAIL-mediated apoptosis – Oliver H. Voss, Daniel Arango, Justin C. Tossey, Miguel A. Villalona Calero and Andrea I. Doseff. https://www.nature.com/articles/s41419-021-03567-1


Necroptosis


Conformational interconversion of MLKL and disengagement from RIPK3 precede cell death by necroptosis – Sarah E. Garnish, Yanxiang Meng, Akiko Koide, Jarrod J. Sandow, Eric Denbaum, Annette V. Jacobsen, Wayland Yeung, Andre L. Samson, Christopher R. Horne, Cheree Fitzgibbon, Samuel N. Young, Phoebe P. C. Smith, Andrew I. Webb, Emma J. Petrie, Joanne M. Hildebrand, Natarajan Kannan, Peter E. Czabotar, Shohei Koide and James M. Murphy. https://www.nature.com/articles/s41467-021-22400-z

A family harboring an MLKL loss of function variant implicates impaired necroptosis in diabetes – Joanne M. Hildebrand, Bernice Lo, Sara Tomei, Valentina Mattei, Samuel N. Young, Cheree Fitzgibbon, James M. Murphy and Abeer Fadda. https://www.nature.com/articles/s41419-021-03636-5

The structure of a minimum amyloid fibril core formed by necroptosis-mediating RHIM of human RIPK3 – Xialian Wu, Yeyang Ma, Kun Zhao, Jing Zhang, Yunpeng Sun, Yichen Li, Xingqi Dong, Hong Hu, Jing Liu, Jian Wang, Xia Zhang, Bing Li, Huayi Wang, Dan Li, Bo Sun, Junxia Lu, and Cong Liu. https://www.pnas.org/content/118/14/e2022933118.abstract?etoc


Pyroptosis


Gasdermin D pore structure reveals preferential release of mature interleukin-1 – Shiyu Xia, Zhibin Zhang, Venkat Giri Magupalli, Juan Lorenzo Pablo, Ying Dong, Setu M. Vora, Longfei Wang, Tian-Min Fu, Matthew P. Jacobson, Anna Greka, Judy Lieberman, Jianbin Ruan and Hao Wu. https://www.nature.com/articles/s41586-021-03478-3

Gasdermin E permits interleukin-1 beta release in distinct sublytic and pyroptotic phases – Bowen Zhou, Derek W. Abbott. https://www.cell.com/cell-reports/fulltext/S2211-1247(21)00312-0


Ferroptosis


Ferroptosis response segregates small cell lung cancer (SCLC) neuroendocrine subtypes – Christina M. Bebber, Emily S. Thomas, Jenny Stroh, Zhiyi Chen, Ariadne Androulidaki, Anna Schmitt, Michaela N. Höhne, Lukas Stüker, Cleidson de Pádua Alves, Armin Khonsari, Marcel A. Dammert, Fatma Parmaksiz, Hannah L. Tumbrink, Filippo Beleggia, Martin L. Sos, Jan Riemer, Julie George, Susanne Brodesser, Roman K. Thomas, H. Christian Reinhardt and Silvia von Karstedt. https://www.nature.com/articles/s41467-021-22336-4

Mitochondrial DNA stress triggers autophagy-dependent ferroptotic death – Changfeng Li, Ying Zhang, Jiao Liu, Rui Kang, Daniel J. Klionsky and Daolin Tang. https://www.tandfonline.com/doi/abs/10.1080/15548627.2020.1739447

Ferroptotic cell death triggered by conjugated linolenic acids is mediated by ACSL1 – Alexander Beatty, Tanu Singh, Yulia Y. Tyurina, Vladimir A. Tyurin, Svetlana Samovich, Emmanuelle Nicolas, Kristen Maslar, Yan Zhou, Kathy Q. Cai, Yinfei Tan, Sebastian Doll, Marcus Conrad, Aravind Subramanian, Hülya Bayır, Valerian E. Kagan, Ulrike Rennefahrt and Jeffrey R. Peterson. https://www.nature.com/articles/s41467-021-22471-y

Branched-chain amino acid aminotransferase 2 regulates ferroptotic cell death in cancer cells – Kang Wang, Zhengyang Zhang, Hsiang-i Tsai, Yanfang Liu, Jie Gao, Ming Wang, Lian Song, Xiongfeng Cao, Zhanxue Xu, Hongbo Chen, Aihua Gong, Dongqing Wang, Fang Cheng and Haitao Zhu. https://www.nature.com/articles/s41418-020-00644-4


Miscellanous


Apoptotic body-mediated intercellular delivery for enhanced drug penetration and whole tumor destruction – Dongyang Zhao, Wenhui Tao, Songhao Li, Yao Chen, Yinghua Sun, Zhonggui He, Bingjun Sun, Jin Sun. https://advances.sciencemag.org/content/7/16/eabg0880

Therapeutic efficiency of the APAF‐1 antagonist LPT99 in a rat model of cisplatin‐induced hearing loss – Silvia Murillo‐Cuesta,  Adelaida M Celaya,  Blanca Cervantes,  Jose M Bermúdez‐Muñoz,  Lourdes Rodríguez‐de la Rosa,  Julio Contreras,  Isabel Sánchez‐Pérez,  and Isabel Varela‐Nieto. https://onlinelibrary.wiley.com/doi/10.1002/ctm2.363

Oxylipin biosynthesis reinforces cellular senescence and allows detection of senolysis – Christopher D. Wiley, Rishi Sharma, Sonnet S. Davis, Marco Demaria, Arvind Ramanathan, Judith Campisi. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(21)00115-7


Reviews


Phagocytic clearance of apoptotic, necrotic, necroptotic and pyroptotic cells – Georgia K. Atkin-Smith. https://portlandpress.com/biochemsoctrans/article/doi/10.1042/BST20200696/228277

Autophagy in tumour immunity and therapy – Houjun Xia, Douglas R. Green and Weiping Zou. https://www.nature.com/articles/s41568-021-00344-2

Cellular degradation systems in ferroptosis – Xin Chen, Chunhua Yu, Rui Kang, Guido Kroemer and Daolin Tang. https://www.nature.com/articles/s41418-020-00728-1

Assembling the right type of switch: Protein condensation to signal cell death – Marta Badia, Benedetta Bolognesi. https://www.sciencedirect.com/science/article/pii/S0955067420301757


Comments


Targeting MCL1 to induce mitophagy is a potential therapeutic strategy for Alzheimer disease – Xufeng Cen, Xiaoyan Xu and Hongguang Xia. https://www.tandfonline.com/doi/full/10.1080/15548627.2020.1860542

Non‐lethal message from the Holy Land: The first international conference on nonapoptotic roles of apoptotic proteins – Eli Arama, Luis Alberto Baena‐Lopez, Howard O. Fearnhead. https://febs.onlinelibrary.wiley.com/doi/full/10.1111/febs.15547

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