ApoList – March 2021

 


Fas and Fas Ligand


A Critical Role for Fas-Mediated Off-Target Tumor Killing in T-cell Immunotherapy – Ranjan Upadhyay, Jonathan A. Boiarsky, Gvantsa Pantsulaia, Judit Svensson-Arvelund, Matthew J. Lin, Aleksandra Wroblewska, Sherry Bhalla, Nathalie Scholler, Adrian Bot, John M. Rossi, Norah Sadek, Samir Parekh, Alessandro Lagana, Alessia Baccarini, Miriam Merad, Brian D. Brown and Joshua D. Brody. https://cancerdiscovery.aacrjournals.org/content/11/3/599

Compromised counterselection by FAS creates an aggressive subtype of germinal center lymphoma – Raud Razzaghi; Shreya Agarwal; Nikita Kotlov; Olga Plotnikova; Krystle Nomie; Da Wei Huang; George W. Wrigh ; Grace A. Smith; Moyi Li; Katsuyoshi Takata; Maryam Yamadi; Chen Yao; John J. O’Shea; James D. Phelan; Stefania Pittaluga; David W. Scott; Jagan R. Muppidi. https://rupress.org/jem/article-abstract/218/3/e20201173/211563

Post-injury immunosuppression and secondary infections are caused by an AIM2 inflammasome-driven signaling cascade [FasL in myeloid cells] – Stefan Roth, Jiayu Cao, Vikramjeet Singh, Steffen Tiedt, Gabriel Hundeshagen, Ting Li, Julia D. Boehme, Dhruv Chauhan, Jie Zhu, Alessio Ricci, Oliver Gorka, Yaw Asare, Jun Yang, Mary S. Lopez, Markus Rehberg, Dunja Bruder, Shengxiang Zhang, Olaf Groß, Martin Dichgans, Veit Hornung, Arthur Liesz. https://www.cell.com/immunity/fulltext/S1074-7613(21)00070-4

Liver metastasis restrains immunotherapy efficacy via macrophage-mediated T cell elimination – Jiali Yu, Michael D. Green, […]Weiping Zou. https://www.nature.com/articles/s41591-020-1131-x


RIPK1


Impaired RIPK1 ubiquitination sensitizes mice to TNF toxicity and inflammatory cell death – Matthias Kist, László G. Kőműves, Tatiana Goncharov, Debra L. Dugger, Charles Yu, Merone Roose-Girma, Kim Newton, Joshua D. Webster and Domagoj Vucic. https://www.nature.com/articles/s41418-020-00629-3

JNK signaling prevents biliary cyst formation through a CASPASE-8–dependent function of RIPK1 during aging – Katrin Müller, Hanna Honcharova-Biletska, Christiane Koppe, Michèle Egger, Lap Kwan Chan, Anne T. Schneider, Lena Küsgens, Friederike Böhm, Yannick Boege, Marc E. Healy, Johannes Schmitt, Sarah Comtesse, Mirco Castoldi, Christian Preisinger, Marta Szydlowska, Enrico Focaccia, Nadine T. Gaisa, Sven H. Loosen, Simone Jörs, Frank Tacke, Christoph Roderburg, Verena Keitel, Johannes G. Bode, Peter Boor, Roger J. Davis, Thomas Longerich, Fabian Geisler, Mathias Heikenwalder, Achim Weber, Mihael Vucur, and Tom Luedde. https://www.pnas.org/content/118/12/e2007194118.abstract


Caspases and Granzyme B


Noncanonical Roles of Caspase-4 and Caspase-5 in Heme-Driven IL-1β Release and Cell Death – Beatriz E. Bolívar, Alexandra N. Brown-Suedel, Brittany A. Rohrman, Chloé I. Charendoff, Vanda Yazdani, John D. Belcher, Gregory M. Vercellotti, Jonathan M. Flanagan and Lisa Bouchier-Hayes. https://www.jimmunol.org/content/early/2021/03/18/jimmunol.2000226

Discovery of a caspase cleavage motif antibody reveals insights into noncanonical inflammasome function – Christopher W. Davies, Irma Stowe, Qui T. Phung, Hoangdung Ho, Corey E. Bakalarski, Aaron Gupta, Yingnan Zhang, Jennie R. Lill, Jian Payandeh, Nobuhiko Kayagaki, and James T. Koerber. https://www.pnas.org/content/118/12/e2018024118.abstract

Cytotoxic CD8+ T cells promote granzyme B-dependent adverse post-ischemic cardiac remodeling – Icia Santos-Zas, Jeremie Lemarié, Ivana Zlatanova, Marine Cachanado, Jean-Christophe Seghezzi, Hakim Benamer, Pascal Goube, Marie Vandestienne, Raphael Cohen, Maya Ezzo, Vincent Duval, Yujiao Zhang, Jin-Bo Su, Alain Bizé, Lucien Sambin, Philippe Bonnin, Maxime Branchereau, Christophe Heymes, Corinne Tanchot, José Vilar, Clement Delacroix, Jean-Sebastien Hulot, Clement Cochain, Patrick Bruneval, Nicolas Danchin, Alain Tedgui, Ziad Mallat, Tabassome Simon, Bijan Ghaleh, Jean-Sébastien Silvestre and Hafid Ait-Oufella. https://www.nature.com/articles/s41467-021-21737-9


Necroptosis


TNF-induced necroptosis initiates early autophagy events via RIPK3-dependent AMPK activation, but inhibits late autophagy – Wenxian Wu, Xiaojing Wang, Yadong Sun, Niklas Berleth, Jana Deitersen, David Schlütermann, Fabian Stuhldreier, Nora Wallot-Hieke, María José Mendiburo, Jan Cox, Christoph Peter, Ann Kathrin Bergmann and Björn Stork. https://www.tandfonline.com/doi/full/10.1080/15548627.2021.1899667

A specific RIP3+ subpopulation of microglia promotes retinopathy through a hypoxia-triggered necroptotic mechanism – Chang He, Yan Liu, Zijing Huang, Ziqi Yang, Tian Zhou, Sheng Liu, Zhaozhe Hao, Jing Wang, Qiumin Feng, Yizhi Liu, Yihai Cao, and Xialin Liu. https://www.pnas.org/content/118/11/e2023290118.abstract?etoc

The amyloid structure of mouse RIPK3 (receptor interacting protein kinase 3) in cell necroptosis – Xia-lian Wu, Hong Hu, Xing-qi Dong, Jing Zhang, Jian Wang, Charles D. Schwieters, Jing Liu, Guo-xiang Wu, Bing Li, Jing-yu Lin, Hua-yi Wang and Jun-xia Lu. https://www.nature.com/articles/s41467-021-21881-2


Pyroptosis / Gasdermin D


Proteomics reveals distinct mechanisms regulating the release of cytokines and alarmins during pyroptosis – Kshiti Phulphagar, Lars I. Kühn, Stefan Ebner, Annika Frauenstein, Jonathan J. Swietlik, Jan Rieckmann, Felix Meissner. https://www.cell.com/cell-reports/fulltext/S2211-1247(21)00140-6

Gasdermin D mediates the maturation and release of IL-1α downstream of inflammasomes – Kohsuke Tsuchiya, Shoko Hosojima, Hideki Hara, Hiroko Kushiyama, Mamunur Rashid Mahib, Takeshi Kinoshita, Takashi Suda. https://www.cell.com/cell-reports/fulltext/S2211-1247(21)00201-1

SARS-CoV-2 engages inflammasome and pyroptosis in human primary monocytes – André C. Ferreira, Vinicius Cardoso Soares, Isaclaudia G. de Azevedo-Quintanilha, Suelen da Silva Gomes Dias, Natalia Fintelman-Rodrigues, Carolina Q. Sacramento, Mayara Mattos, Caroline S. de Freitas, Jairo R. Temerozo, Lívia Teixeira, Eugenio Damaceno Hottz, Ester A. Barreto, Camila R. R. Pão, Lohanna Palhinha, Milene Miranda, Dumith Chequer Bou-Habib, Fernando A. Bozza, Patrícia T. Bozza and Thiago Moreno L. Souza. https://www.nature.com/articles/s41420-021-00428-w


Ferroptosis


A compendium of kinetic modulatory profiles identifies ferroptosis regulators – Megan Conlon, Carson D. Poltorack, Giovanni C. Forcina, David A. Armenta, Melodie Mallais, Marcos A. Perez, Alex Wells, Alexis Kahanu, Leslie Magtanong, Jennifer L. Watts, Derek A. Pratt and Scott J. Dixon. https://www.nature.com/articles/s41589-021-00751-4

The Lipogenic Regulator SREBP2 Induces Transferrin in Circulating Melanoma Cells and Suppresses Ferroptosis – Xin Hong, Whijae Roh, Ryan J. Sullivan, Keith H.K. Wong, Ben S. Wittner, Hongshan Guo, Taronish D. Dubash, Moshe Sade-Feldman, Benjamin Wesley, Elad Horwitz, Genevieve M. Boland, Dieuwke L. Marvin, Todd Bonesteel, Chenyue Lu, François Aguet, Risa Burr, Samuel S. Freeman, Laxmi Parida, Katherine Calhoun, Michelle K. Jewett, Linda T. Nieman, Nir Hacohen, Anders M. Näär, David T. Ting, Mehmet Toner, Shannon L. Stott, Gad Getz, Shyamala Maheswaran and Daniel A. Haber. https://cancerdiscovery.aacrjournals.org/content/11/3/678

Ferroptosis Inducers Are a Novel Therapeutic Approach for Advanced Prostate Cancer – Ali Ghoochani, En-Chi Hsu, Merve Aslan, Meghan A. Rice, Holly M. Nguyen, James D. Brooks, Eva Corey, Ramasamy Paulmurugan and Tanya Stoyanova. https://cancerres.aacrjournals.org/content/81/6/1583

Lipid peroxidation and the subsequent cell death transmitting from ferroptotic cells to neighboring cells – Hironari Nishizawa, Mitsuyo Matsumoto, Guan Chen, Yusho Ishii, Keisuke Tada, Masafumi Onodera, Hiroki Kato, Akihiko Muto, Kozo Tanaka and Kazuhiko Igarashi. https://www.nature.com/articles/s41419-021-03613-y


Efferocytosis, entosis etc


Pulsatile contractions promote apoptotic cell extrusion in epithelial tissues – Youmna Atieh, Thomas Wyatt, Ana Maria Zaske, George T. Eisenhoffer. https://www.cell.com/current-biology/fulltext/S0960-9822(20)31825-X

Mechanotransduction activates RhoA in the neighbors of apoptotic epithelial cells to engage apical extrusion – Kinga Duszyc, Guillermo A. Gomez, Anne K. Lagendijk, Mei-Kwan Yau, Bageshri Naimish Nanavati, Briony L. Gliddon, Thomas E. Hall, Suzie Verma, Benjamin M. Hogan, Stuart M. Pitson, David P. Fairlie, Robert G. Parton, Alpha S. Yap. https://www.cell.com/current-biology/fulltext/S0960-9822(21)00036-1

Caspase cleavage releases a nuclear protein fragment that stimulates phospholipid scrambling at the plasma membrane – Masahiro Maruoka, Panpan Zhang, Hiromi Mori, Eiichi Imanishi, Daniel M. Packwood, Hiroshi Harada, Hidetaka Kosako, Jun Suzuki. https://www.cell.com/molecular-cell/fulltext/S1097-2765(21)00135-0


Bcl-2 family proteins


Structure of detergent-activated BAK dimers derived from the inert monomer – Richard W. Birkinshaw, Sweta Iyer, Daisy Lio, Cindy S. Luo,J ason M. Brouwer, Michelle S. Miller, Adeline Y. Robin, Rachel T. Uren, Grant Dewson, Ruth M. Kluck, Peter M. Colman, Peter E. Czabotar. https://www.cell.com/molecular-cell/fulltext/S1097-2765(21)00182-9

Phase IB Study of Osimertinib in Combination with Navitoclax in EGFR-mutant NSCLC Following Resistance to Initial EGFR Therapy (ETCTN 9903) – Erin M. Bertino, Ryan D. Gentzler, Sarah Clifford, Jill Kolesar, Alona Muzikansky, Eric B. Haura, Zofia Piotrowska, D. Ross Camidge, Thomas E. Stinchcombe, Christine Hann, Jyoti Malhotra, Liza C. Villaruz, Cloud P. Paweletz, Christie L. Lau, Lynette Sholl, Naoko Takebe, Jeffrey A. Moscow, Geoffrey I. Shapiro, Pasi A. Jänne and Geoffrey R. Oxnard. https://clincancerres.aacrjournals.org/content/27/6/1604

Hypertonicity counteracts MCL‐1 and renders BCL‐XL a synthetic lethal target in head and neck cancer – Sina Heimer, Gertrud Knoll, Patrick Neubert, Karin P. Hammer, Stefan Wagner, Richard J. Bauer, Jonathan Jantsch, Martin Ehrenschwender. https://febs.onlinelibrary.wiley.com/doi/full/10.1111/febs.15492

Network-based systems pharmacology reveals heterogeneity in LCK and BCL2 signaling and therapeutic sensitivity of T-cell acute lymphoblastic leukemia – Yoshihiro Gocho, Jingjing Liu, Jianzhong Hu, Wentao Yang, Neekesh V. Dharia, Jingliao Zhang, Hao Shi, Guoqing Du, August John, Ting-Nien Lin, Jeremy Hunt, Xin Huang, Bensheng Ju, Lauren Rowland, Lei Shi, Dylan Maxwell, Brandon Smart, Kristine R. Crews, Wenjian Yang, Kohei Hagiwara, Yingchi Zhang, Kathryn Roberts, Hong Wang, Elias Jabbour, Wendy Stock, Bartholomew Eisfelder, Elisabeth Paietta, Scott Newman, Giovanni Roti, Mark Litzow, John Easton, Jinghui Zhang, Junmin Peng, Hongbo Chi, Stanley Pounds, Mary V. Relling, Hiroto Inaba, Xiaofan Zhu, Steven Kornblau, Ching-Hon Pui, Marina Konopleva, David Teachey, Charles G. Mullighan, Kimberly Stegmaier, William E. Evans, Jiyang Yu and Jun J. Yang. https://www.nature.com/articles/s43018-020-00167-4

Combined inhibition of XIAP and BCL2 drives maximal therapeutic efficacy in genetically diverse aggressive acute myeloid leukemia – Mari Hashimoto, Yoriko Saito, Ryo Nakagawa, Ikuko Ogahara, Shinsuke Takagi, Sadaaki Takata, Hanae Amitani, Mikiko Endo, Hitomi Yuki, Jordan A. Ramilowski, Jessica Severin, Ri-ichiroh Manabe, Takashi Watanabe, Kokoro Ozaki, Akiko Kaneko, Hiroshi Kajita, Saera Fujiki, Kaori Sato, Teruki Honma, Naoyuki Uchida, Takehiro Fukami, Yasushi Okazaki, Osamu Ohara, Leonard D. Shultz, Makoto Yamada, Shuichi Taniguchi, Paresh Vyas, Michiel de Hoon, Yukihide Momozawa and Fumihiko Ishikawa. https://www.nature.com/articles/s43018-021-00177-w

The deubiquitinase (DUB) USP13 promotes Mcl-1 stabilisation in cervical cancer – Ethan L. Morgan, Molly R. Patterson, Diego Barba-Moreno, James A. Scarth, Adam Wilson and Andrew Macdonald. https://www.nature.com/articles/s41388-021-01679-8

BOK controls apoptosis by Ca2+ transfer through ER-mitochondrial contact sites – Marcos A. Carpio, Robert E. Means, Allison L. Brill, Alva Sainz, Barbara E. Ehrlich, Samuel G. Katz. https://www.cell.com/cell-reports/fulltext/S2211-1247(21)00141-8

Cullin-5 neddylation-mediated NOXA degradation is enhanced by PRDX1 oligomers in colorectal cancer – Shoufang Xu, Yilei Ma, Qingchao Tong, Jun Yang, Jia Liu, Yanzhong Wang, Guoli Li, Jin Zeng, Sining Fang, Fengying Li, Xinyou Xie and Jun Zhang. https://www.nature.com/articles/s41419-021-03557-3


Miscellanous


Circulating BiP/Grp78 is a novel prognostic marker for sepsis‐mediated immune cell death – Marcel Doerflinger  Boris Reljic  Joseph Menassa  Christina Nedeva  Irvin Jose  Pierre Faou  Liana Mackiewicz  Ashley Mansell  Marc Pellegrini  Richard Hotchkiss  Hamsa Puthalakath. https://febs.onlinelibrary.wiley.com/doi/abs/10.1111/febs.15552

Conversion of the death inhibitor ARC to a killer activates pancreatic β cell death in diabetes – Wendy M. McKimpson, Yun Chen, James A. Irving, Min Zheng, Jeremy Weinberger, Wilson Lek Wen Tan, Zenia Tiang, Alistair M. Jagger, Streamson C. Chua Jr., Jeffrey E. Pessin, Roger S.-Y. Foo, David A. Lomas, Richard N. Kitsis. https://www.cell.com/developmental-cell/fulltext/S1534-5807(21)00122-2

Monitoring tumor cell death in murine tumor models using deuterium magnetic resonance spectroscopy and spectroscopic imaging – Friederike Hesse, Vencel Somai, Felix Kreis, Flaviu Bulat, Alan J. Wright, and Kevin M. Brindle. https://www.pnas.org/content/118/12/e2014631118.abstract

Conserved role of ENDOG in promoting autophagy – Jianshuang Li, Wenjun Wang and Qinghua Zhou. https://www.tandfonline.com/doi/abs/10.1080/15548627.2021.1907513

The BAX-binding protein MOAP1 associates with LC3 and promotes closure of the phagophore – Hao-Chun Chang, Ran N. Tao, Chong Teik Tan, Ya Jun Wu, Boon Huat Bay and Victor C. Yu. https://www.tandfonline.com/doi/full/10.1080/15548627.2021.1896157


Reviews


The intrinsic immunogenic properties of cancer cell lines, immunogenic cell death, and how these influence host antitumor immune responses – Tania Løve Aaes and Peter Vandenabeele. https://www.nature.com/articles/s41418-020-00658-y

The regulation of necroptosis by post-translational modifications – Yanxiang Meng, Jarrod J. Sandow, Peter E. Czabotar and James M. Murphy. https://www.nature.com/articles/s41418-020-00722-7

An unexpected turn of fortune: targeting TRAIL-Rs in KRAS-driven cancer – Von Karstedt S, Walczak H.. https://www.nature.com/articles/s41420-020-0249-4

Death sentence: The tale of a fallen endoplasmic reticulum – Eoghan P.McGrath, Federica G.Centonze, Eric Chevet, Tony Avril, Elodie Lafont. https://www.sciencedirect.com/science/article/abs/pii/S0167488921000550


Comments


Challenges in small-molecule target identification: a commentary on “BDA-366, a putative Bcl-2 BH4 domain antagonist, induces apoptosis independently of Bcl-2 in a variety of cancer cell models” – Richard W. Birkinshaw. https://www.nature.com/articles/s41418-020-00717-4

NINJ1, rupturing swollen membranes for cataclysmic cell lysis – Yupeng Wang, Feng Shao. https://www.cell.com/molecular-cell/fulltext/S1097-2765(21)00173-8

The long road to TRAIL therapy: a TRAILshort detour – Aswath P. Chandrasekar, Mark Maynes, and  Andrew D. Badley. https://impactjournals.us9.list-manage.com/track/click?u=133779c099e52b6fa9d4dec2e&id=26664d3f1d&e=923b339f12

Linking hyperosmotic stress and apoptotic sensitivity – Daniela Stöhr, Markus Rehm. https://febs.onlinelibrary.wiley.com/doi/full/10.1111/febs.15520

From friend to foe: Pro-apoptotic action of nuclear ARC in diabetes – Toshiharu Onodera, Philipp E. Scherer. https://www.cell.com/developmental-cell/fulltext/S1534-5807(21)00198-2

Epithelia arm up for dead-cell clearance – Paulina Strzyz. https://www.nature.com/articles/s41580-021-00351-z

Profile of Judy Lieberman – Jennifer Viegas. https://www.pnas.org/content/118/12/e2103317118?etoc=

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