ApoList – February 2021


Reviews


The Antisocial Network: Cross Talk Between Cell Death Programs in Host Defense – Annelise G. Snyder and Andrew Oberst. https://www.annualreviews.org/doi/10.1146/annurev-immunol-112019-072301

Cell death pathways: intricate connections and disease implications – Matthias Kist, Domagoj Vucic. https://www.embopress.org/doi/abs/10.15252/embj.2020106700

Location, location, location: A compartmentalized view of TNF-induced necroptotic signaling – André L. Samson, Sarah E. Garnish, Joanne M. Hildebrand, and James M. Murphy. https://stke.sciencemag.org/content/14/668/eabc6178

Modes of Regulated Cell Death in Cancer – Elle Koren and Yaron Fuchs. https://cancerdiscovery.aacrjournals.org/content/11/2/245

Fueling the Fire: Inflammatory Forms of Cell Death and Implications for Cancer Immunotherapy – Sheera R. Rosenbaum, Nicole A. Wilski and Andrew E. Aplin. https://cancerdiscovery.aacrjournals.org/content/11/2/266

Ferroptosis: mechanisms, biology and role in disease – Xuejun Jiang, Brent R. Stockwell and Marcus Conrad. https://www.nature.com/articles/s41580-020-00324-8

Role of apoptosis repressor with caspase recruitment domain (ARC) in cell death and cardiovascular disease – Jing Zhang, Xianxin Zheng, Peiyan Wang, Jianxun Wang, Wei Ding. https://link.springer.com/article/10.1007/s10495-020-01653-x

The application of BH3 mimetics in myeloid leukemias – Narissa Parry, Helen Wheadon and Mhairi Copland. https://www.nature.com/articles/s41419-021-03500-6

Discovery of linear ubiquitination, a crucial regulator for immune signaling and cell death – Kazuhiro Iwai. https://febs.onlinelibrary.wiley.com/doi/full/10.1111/febs.15471

The Role of Mitochondria in Pyroptosis – Qian Li, Nengxian Shi, Chen Cai, Mingming Zhang, Jing He, Ying Tan and Weijun Fu. https://www.frontiersin.org/articles/10.3389/fcell.2020.630771/full

Ubiquitination in the regulation of inflammatory cell death and cancer – Peter E. Cockram, Matthias Kist, Sumit Prakash, Si-Han Chen, Ingrid E. Wertz and Domagoj Vucic. https://www.nature.com/articles/s41418-020-00708-5


Bcl-2 family proteins


Proteolysis-targeting chimera against BCL-XL destroys tumor-infiltrating regulatory T cells – Ryan Kolb, Umasankar De, Sajid Khan, Yuewan Luo, Myung-Chul Kim, Haijun Yu, Chaoyan Wu, Jiao Mo, Xin Zhang, Peiyi Zhang, Xuan Zhang, Nicholas Borcherding, Daniel Koppel, Yang-Xin Fu, Song Guo Zheng, Dorina Avram, Guangrong Zheng, Daohong Zhou and Weizhou Zhang. https://www.nature.com/articles/s41467-021-21573-x

Eltrombopag directly inhibits BAX and prevents cell death – Adam Z. Spitz, Emmanouil Zacharioudakis, Denis E. Reyna, Thomas P. Garner and Evripidis Gavathiotis. https://www.nature.com/articles/s41467-021-21224-1

Characteristics of intracellular propagation of mitochondrial BAX recruitment during apoptosis – Joshua A. Grosser, Margaret E. Maes, Robert W. Nickells. https://link.springer.com/article/10.1007/s10495-020-01654-w

Fluorizoline-induced apoptosis requires prohibitins in nematodes and human cells – José Saura-Esteller, Ismael Sánchez-Vera, Sonia Núñez-Vázquez, Judith Jabalquinto-Carrasco, Ana M. Cosialls, Lorena Mendive-Tapia, Dmytro Kukhtar, Manuel D. Martínez-Bueno, Rodolfo Lavilla, Julián Cerón, Marta Artal-Sanz, Gabriel Pons, Daniel Iglesias-Serret, Joan Gil. https://link.springer.com/article/10.1007/s10495-020-01651-z

NOXA upregulation by the prohibitin‐binding compound fluorizoline is transcriptionally regulated by integrated stress response‐induced ATF3 and ATF4 – Sonia Núñez‐Vázquez, Ismael Sánchez‐Vera, José Saura‐Esteller, Ana M. Cosialls, Anaïs F.M. Noisier, Fernando Albericio, Rodolfo Lavilla, Gabriel Pons, Daniel Iglesias‐Serret, Joan Gil. https://febs.onlinelibrary.wiley.com/doi/abs/10.1111/febs.15480

TOM20-mediated transfer of Bcl2 from ER to MAM and mitochondria upon induction of apoptosis – Lisenn Lalier, Vincent Mignard, Marie-Pierre Joalland, Didier Lanoé, Pierre-François Cartron, Stéphen Manon and François M. Vallette. https://www.nature.com/articles/s41419-021-03471-8


Death receptors


Cryo-EM structural analysis of FADD:Caspase-8 complexes defines the catalytic dimer architecture for co-ordinated control of cell fate – Joanna L. Fox, Michelle A. Hughes, Xin Meng, Nikola A. Sarnowska, Ian R. Powley, Rebekah Jukes-Jones, David Dinsdale, Timothy J. Ragan, Louise Fairall, John W. R. Schwabe, Nobuhiro Morone, Kelvin Cain and Marion MacFarlane. https://www.nature.com/articles/s41467-020-20806-9

Ancestral role of TNF-R pathway in cell differentiation in the basal metazoan Hydra – Mona Steichele, Lara S. Sauermann, Ann-Christine König, Stefanie Hauck and Angelika Böttger. http://jcs.biologists.org/content/134/2/jcs255422?etoc

A distinct CD38+CD45RA+ population of CD4+, CD8+, and double-negative T cells is controlled by FA – Maria Elena Maccari; Sebastian Fuchs; Patrick Kury ; Geoffroy Andrieux; Simon Völkl; Bertram Bengsch; Myriam Ricarda Lorenz; Maximilian Heeg ; Jan Rohr; Sabine Jägle; Carla N. Castro; Miriam Groß; Ursula Warthorst ; Christoph König; Ilka Fuchs; Carsten Speckmann; Julian Thalhammer; Friedrich G. Kapp ; Markus G. Seidel; Gregor Dückers; Stefan Schönberger; Catharina Schütz; Marita Führer; Robin Kobbe; Dirk Holzinger; Christian Klemann; Petr Smisek; Stephen Owens; Gerd Horneff; Reinhard Kolb; Nora Naumann-Bartsch; Maurizio Miano; Julian Staniek; Marta Rizzi; Tomas Kalina; Pascal Schneider; Anika Erxleben; Rolf Backofen ; Arif Ekici; Charlotte M. Niemeyer; Klaus Warnatz; Bodo Grimbacher; Hermann Eibel ; Andreas Mackensen; Andreas Philipp Frei; Klaus Schwarz; Melanie Boerries; Stephan Ehl; Anne Rensing-Ehl. https://rupress.org/jem/article-abstract/218/2/e20192191/211525

A TRAIL from gut to brain – John F. Foley. https://stke.sciencemag.org/content/14/671/eabh1677


Caspases and IAPs


Engineering caspase 7 as an affinity reagent to capture proteolytic products – Amir S. Razai, Scott J. Snipas, Marcin Poreba, Domenico Fasci, Guy S. Salvesen. https://febs.onlinelibrary.wiley.com/doi/abs/10.1111/febs.15467

Smac-mimetics reduce numbers and viability of human osteoclasts – Ingrid Nyhus Moen, Marita Westhrin, Erling Håland, Markus Haug, Unni Nonstad, Merisa Klaharn, Therese Standal and Kristian K. Starheim. https://www.nature.com/articles/s41420-021-00415-1

Targeting the ESCRT-III component CHMP2A for noncanonical Caspase-8 activation on autophagosomal membranes – Tatsuya Hattori, Yoshinori Takahashi, Longgui Chen, Zhenyuan Tang, Carson A. Wills, Xinwen Liang and Hong-Gang Wang. https://www.nature.com/articles/s41418-020-00610-0


Necroptosis


USP22 controls necroptosis by regulating receptor‐interacting protein kinase 3 ubiquitination – Jens Roedig, Lisa Kowald, Thomas Juretschke, Rebekka Karlowitz, Behnaz Ahangarian Abhari, Heiko Roedig, Simone Fulda, Petra Beli, Sjoerd JL van Wijk. https://www.embopress.org/doi/full/10.15252/embr.202050163

Somatic Epigenetic Silencing of RIPK3 Inactivates Necroptosis and Contributes to Chemoresistance in Malignant Mesothelioma – Yinfei Tan, Eleonora Sementino, Mitchell Cheung, Suraj Peri, Craig W. Menges, Anna-Mariya Kukuyan, Ting Zhang, Vladimir Khazak, Lauren A. Fox, Eric A. Ross, Suresh Ramanathan, Suresh C. Jhanwar, Raja M. Flores, Siddharth Balachandran and Joseph R. Testa. https://clincancerres.aacrjournals.org/content/27/4/1200

A class of viral inducer of degradation of the necroptosis adaptor RIPK3 regulates virus-induced inflammation – Zhijun Liu, Himani Nailwal, Jonah Rector, Masmudur M. Rahman, Richard Sam, Grant McFadden, Francis Ka-Ming Chan. https://www.cell.com/immunity/fulltext/S1074-7613(20)30507-0


Pyroptosis


Apaf-1 Pyroptosome Senses Mitochondrial Permeability Transition – Wanfeng Xu, Yuan Che, Quan Zhang, Hai Huang, Chujie Ding, Yun Wang, Guangji Wang, Lijuan Cao, Haiping Hao. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(20)30653-7

Caspase 3/GSDME-dependent pyroptosis contributes to chemotherapy drug-induced nephrotoxicity – Xiujin Shen, Haibing Wang, Chunhua Weng, Hong Jiang and Jianghua Chen. https://www.nature.com/articles/s41419-021-03458-5

Gasdermin E deficiency attenuates acute kidney injury by inhibiting pyroptosis and inflammation – Weiwei Xia, Yuanyuan Li, Mengying Wu, Qianqian Jin, Qian Wang, Shuzhen Li, Songming Huang, Aihua Zhang, Yue Zhang and Zhanjun Jia. https://www.nature.com/articles/s41419-021-03431-2


Ferroptosis


Phospholipase iPLA2β averts ferroptosis by eliminating a redox lipid death signal – Wan-Yang Sun, Vladimir A. Tyurin, Karolina Mikulska-Ruminska, Indira H. Shrivastava, Tamil S. Anthonymuthu, Yu-Jia Zhai, Ming-Hai Pan, Hai-Biao Gong, Dan-Hua Lu, Jie Sun, Wen-Jun Duan, Sergey Korolev, Andrey Y. Abramov, Plamena R. Angelova, Ian Miller, Ofer Beharier, Gao-Wei Mao, Haider H. Dar, Alexandr A. Kapralov, Andrew A. Amoscato, Teresa G. Hastings, Timothy J. Greenamyre, Charleen T. Chu, Yoel Sadovsky, Ivet Bahar, Hülya Bayır, Yulia Y. Tyurina, Rong-Rong He and Valerian E. Kagan. https://www.nature.com/articles/s41589-020-00734-x

Polyunsaturated fatty acid biosynthesis pathway determines ferroptosis sensitivity in gastric cancer – Ji-Yoon Lee, Miso Nam, Hye Young Son, Kwangbeom Hyun, Seo Young Jang, Jong Woo Kim, Min Wook Kim, Youngae Jung , Eunji Jang, Seon-Jin Yoon 8, Jungeun Kim, Jihye Kim, Jinho Seo, Jeong-Ki Min, Kyoung-Jin Oh, Baek-Soo Han, Won Kon Kim, Kwang-Hee Bae, Jaewhan Song, Jaehoon Kim, Yong-Min Huh, Geum-Sook Hwang, Eun-Woo Lee, Sang Chul Lee. https://www.pnas.org/content/117/51/32433.long


Entosis, extrusion, efferocytosis


p53-dependent elimination of aneuploid mitotic offspring by entosis – Jianqing Liang, Zubiao Niu, Bo Zhang, Xiaochen Yu, You Zheng, Chenxi Wang, He Ren, Manna Wang, Banzhan Ruan, Hongquan Qin, Xin Zhang, Songzhi Gu, Xiaoyong Sai, Yanhong Tai, Lihua Gao, Li Ma, Zhaolie Chen, Hongyan Huang, Xiaoning Wang and Qiang Sun. https://www.nature.com/articles/s41418-020-00645-3

Mechanical competition triggered by innate immune signaling drives the collective extrusion of bacterially infected epithelial cells – Effie E. Bastounis, Francisco Serrano-Alcalde, Prathima Radhakrishnan, Patrik Engström, María J. Gómez-Benito, Mackenzi S. Oswald, Yi-Ting Yeh, Jason G. Smith, Matthew D. Welch, José M. García-Aznar, Julie A. Theriot. https://www.cell.com/developmental-cell/fulltext/S1534-5807(21)00070-8

Calcium ions trigger the exposure of phosphatidylserine on the surface of necrotic cells – Yoshitaka Furuta, Omar Pena-Ramos, Zao Li, Lucia Chiao, Zheng Zhou. https://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1009066


Miscellanous


Centriolar distal appendages activate the centrosome‐PIDDosome‐p53 signalling axis via ANKRD26 – Matteo Burigotto, Alessia Mattivi, Daniele Migliorati, Giovanni Magnani, Chiara Valentini, Michela Roccuzzo, Martin Offterdinger, Massimo Pizzato, Alexander Schmidt, Andreas Villunger, Stefano Maffini, Luca L Fava. https://www.embopress.org/doi/full/10.15252/embj.2020104844

ANKRD26 recruits PIDD1 to centriolar distal appendages to activate the PIDDosome following centrosome amplification – Lauren T Evans, Taylor Anglen, Phillip Scott, Kimberly Lukasik, Jadranka Loncarek, Andrew J Holland. https://www.embopress.org/doi/abs/10.15252/embj.2020105106

Intracellular leucine-rich alpha-2-glycoprotein-1 competes with Apaf-1 for binding cytochrome c in protecting MCF-7 breast cancer cells from apoptosis – Ronald Jemmerson, Katherine Staskus, LeeAnn Higgins, Kathleen Conklin, Ameeta Kelekar. https://link.springer.com/article/10.1007/s10495-020-01647-9

Altered structure and dynamics of pathogenic cytochrome c variants correlate with increased apoptotic activity – Matthias Fellner; Rinky Parakra; Kirstin O. McDonald; Itamar Kass ; Guy N.L. Jameson; Sigurd M. Wilbanks; Elizabeth C. Ledgerwood. https://portlandpress.com/biochemj/article-abstract/478/3/669/227642/

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