ApoList – January 2021

 


Pyroptosis and other forms of cell death


NINJ1 mediates plasma membrane rupture during lytic cell death – Nobuhiko Kayagaki, Opher S. Kornfeld, Bettina L. Lee, Irma B. Stowe, Karen O’Rourke, Qingling Li, Wendy Sandoval, Donghong Yan, Jing Kang, Min Xu, Juan Zhang, Wyne P. Lee, Brent S. McKenzie, Gözde Ulas, Jian Payandeh, Merone Roose-Girma, Zora Modrusan, Rohit Reja, Meredith Sagolla, Joshua D. Webster, Vicky Cho, T. Daniel Andrews, Lucy X. Morris, Lisa A. Miosge, Christopher C. Goodnow, Edward M. Bertram and Vishva M. Dixit – https://www.nature.com/articles/s41586-021-03218-7

Role and dynamics of vacuolar pH during cell-in-cell mediated death – Yan Su, He Ren, Meng Tang, You Zheng, Bo Zhang, Chenxi Wang, Xinyu Hou, Zubiao Niu, Zhongyi Wang, Xiaoyan Gao, Lihua Gao, Hong Jiang, Zhaolie Chen, Tianzhi Luo and Qiang Sun. https://www.nature.com/articles/s41419-021-03396-2

Coral gasdermin triggers pyroptosis – Shuai Jiang, Zhi Zhou, Yuanyuan Sun, Tengfei Zhang, Li Su. https://immunology.sciencemag.org/content/5/54/eabd2591


Death receptors


Gut-licensed IFNγ+ NK cells drive LAMP1+TRAIL+ anti-inflammatory astrocytes – Liliana M. Sanmarco, Michael A. Wheeler, Cristina Gutiérrez-Vázquez, Carolina Manganeli Polonio, Mathias Linnerbauer, Felipe A. Pinho-Ribeiro, Zhaorong Li, Federico Giovannoni, Katelyn V. Batterman, Giulia Scalisi, Stephanie E. J. Zandee, Evelyn S. Heck, Moneera Alsuwailm, Douglas L. Rosene, Burkhard Becher, Isaac M. Chiu, Alexandre Prat and Francisco J. Quintana. https://www.nature.com/articles/s41586-020-03116-4

Autophagy protects tumors from T cell–mediated cytotoxicity via inhibition of TNFα-induced apoptosis – Tara M. Young, Claudia Reyes, Elizabeth Pasnikowski, Carla Castanaro, Chung Wong, Corinne E. Decker, Joyce Chiu, Hang Song, Yi Wei, Yu Bai, Brian Zambrowicz, Gavin Thurston, Christopher Daly. https://immunology.sciencemag.org/content/5/54/eabb9561

Synergism of TNF-α and IFN-γ Triggers Inflammatory Cell Death, Tissue Damage, and Mortality in SARS-CoV-2 Infection and Cytokine Shock Syndromes – Rajendra Karki, Bhesh Raj Sharma, Shraddha Tuladhar, Evan Peter Williams, Lillian Zalduondo, Parimal Samir, Min Zheng, Balamurugan Sundaram, Balaji Banoth, R.K. Subbarao Malireddi, Patrick Schreiner, Geoffrey Neale, Peter Vogel, Richard Webby, Colleen Beth Jonsson, Thirumala-Devi Kanneganti. https://www.cell.com/cell/fulltext/S0092-8674(20)31542-7


Necroptosis


RIP3-mediated necroptosis is regulated by inter-filament assembly of RIP homotypic interaction motif – Hong Hu, Xialian Wu, Guoxiang Wu, Ning Nan, Jing Zhang, Xinxin Zhu, Yu Zhang, Zhaoqian Shu, Jia Liu, Xiaoyan Liu, Junxia Lu and Huayi Wang. https://www.nature.com/articles/s41418-020-0598-9

O-GlcNAcylation ameliorates the pathological manifestations of Alzheimer’s disease by inhibiting necroptosis – Jinsu Park , Hee-Jin Ha, Eun Seon Chung, Seung Hyun Baek, Yoonsuk Cho, Hark Kyun Kim, Jihoon Han, Jae Hoon Sul, Jeongmi Lee, Eunae Kim, Junsik Kim, Yong Ryoul Yang, Mikyoung Park, Sung Hyun Kim, Thiruma V. Arumugam, Hyemin Jang, Sang Won Seo, Pann-Ghill Suh, Dong-Gyu Jo. https://advances.sciencemag.org/content/7/3/eabd3207?utm

The necroptotic cell death pathway operates in megakaryocytes, but not in platelet synthesis – Diane Moujalled, Pradnya Gangatirkar, Maria Kauppi, Jason Corbin, Marion Lebois, James M. Murphy, Najoua Lalaoui, Joanne M. Hildebrand, John Silke, Warren S. Alexander and Emma C. Josefsson. https://www.nature.com/articles/s41419-021-03418-z

ZBP1 promotes LPS-induced cell death and IL-1β release via RHIM-mediated interactions with RIPK1 – Hayley I. Muendlein, Wilson M. Connolly, Zoie Magri, Irina Smirnova, Vladimir Ilyukha, Avishekh Gautam, Alexei Degterev and Alexander Poltorak. https://www.nature.com/articles/s41467-020-20357-z


Bcl-2 family proteins


Venetoclax Increases Intratumoral Effector T Cells and Antitumor Efficacy in Combination with Immune Checkpoint Blockade – Frederick J. Kohlhapp, Dipica Haribhai, Rebecca Mathew, Ryan Duggan, Paul A. Ellis, Rui Wang, Elisabeth A. Lasater, Yan Shi, Nimita Dave, Jacob J. Riehm, Valerie A. Robinson, An D. Do, Yijin Li, Christine J. Orr, Deepak Sampath, Aparna Raval, Mark Merchant, Anahita Bhathena, Ahmed Hamed Salem, Keith M. Hamel, Joel D. Leverson, Cherrie Donawho, William N. Pappano and Tamar Uziel. https://cancerdiscovery.aacrjournals.org/content/11/1/68

Impaired ribosome biogenesis checkpoint activation induces p53-dependent MCL-1 degradation and MYC-driven lymphoma death – Ana Domostegui, Suresh Peddigari, Carol A Mercer, Flavia Iannizzotto, Marta-Leonor Rodriguez, Marta Garcia-Cajide, Virginia Amador, Ramón Salazar, Sara C Kozma, Eric P Kusnadi, Jian Kang, Antonio Gentilella, Richard B Pearson, George Thomas, Joffrey Pelletier. https://ashpublications.org/blood/article/doi/10.1182/blood.2020007452/474958

GNA13 regulates BCL2 expression and the sensitivity of GCB-DLBCL cells to BCL2 inhibitors in a palmitoylation-dependent manner – Zhizhou Xia, Xiuli Zhang, Ping Liu, Ruihong Zhang, Zhangsen Huang, Donghe Li, Xinhua Xiao, Min Wu, Nannan Ning, Qianqian Zhang, Jianmin Zhang, Mingzhu Liu, Bo Jiao and Ruibao Ren. https://www.nature.com/articles/s41419-020-03311-1


Caspases


Phosphorylation by Aurora B kinase regulates caspase-2 activity and function – Yoon Lim, Dylan De Bellis, Jarrod J. Sandow, Luisa Capalbo, Pier Paolo D’Avino, James M. Murphy, Andrew I. Webb, Loretta Dorstyn and Sharad Kumar. https://www.nature.com/articles/s41418-020-00604-y


Ferroptosis


Membrane Damage during Ferroptosis Is Caused by Oxidation of Phospholipids Catalyzed by the Oxidoreductases POR and CYB5R1 – Bo Yan, Youwei Ai, Qi Sun, Yan Ma, Yang Cao, Jiawen Wang, Zhiyuan Zhang, Xiaodong Wang. https://www.cell.com/molecular-cell/fulltext/S1097-2765(20)30802-9

Tumor heterogeneity in autophagy-dependent ferroptosis – Jingbo Li, Jiao Liu, Yinghua Xu, Runliu Wu, Xin Chen, Xinxin Song, Herbert Zeh, Rui Kang, Daniel J. Klionsky, Xiaoyan Wang and Daolin Tang. https://www.tandfonline.com/doi/abs/10.1080/15548627.2021.1872241

NUPR1 is a critical repressor of ferroptosis – Jiao Liu, Xinxin Song, Feimei Kuang, Qiuhong Zhang, Yangchun Xie, Rui Kang, Guido Kroemer and Daolin Tang. https://www.nature.com/articles/s41467-021-20904-2


Miscellanous


A stress‐induced tyrosine‐tRNA depletion response mediates codon‐based translational repression and growth suppression – Doowon Huh, Maria C Passarelli, Jenny Gao, Shahnoza N Dusmatova, Clara Goin, Lisa Fish, Alexandra M Pinzaru, Henrik Molina, Zhiji Ren, Elizabeth A McMillan, Hosseinali Asgharian, Hani Goodarzi, Sohail F Tavazoie. https://www.embopress.org/doi/abs/10.15252/embj.2020106696


Reviews


Neuronal cell life, death, and axonal degeneration as regulated by the BCL-2 family proteins – James M. Pemberton, Justin P. Pogmore and David W. Andrews. https://www.nature.com/articles/s41418-020-00654-2

A venetoclax bench-to-bedside story – Courtney D. DiNardo and Marina Y. Konopleva. https://www.nature.com/articles/s43018-020-00165-6


Comments


Lighting a fire on the reef – Zhibin Zhang, Judy Lieberman. https://immunology.sciencemag.org/content/5/54/eabf0905

From the T-cell receptor to cancer therapy: an interview with Tak W. Mak – Tak W. Mak. https://www.nature.com/articles/s41418-020-00666-y

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