ApoList – December 2020

Bcl-2 family proteins


Inhibition of the anti-apoptotic protein MCL-1 severely suppresses human hematopoiesis – Sheila Bohler, Sehar Afreen, Juncal Fernandez-Orth, Eva-Maria Demmerath, Christian Molnar, Ying Wu, Julia Miriam Weiss, Venugopal Rao Mittapalli, Lukas Konstantinidis, Hagen Schmal, Mirjam Kunze, Miriam Erlacher. https://haematologica.org/article/view/haematol.2020.252130
 
BCL‐XL exerts a protective role against anemia caused by radiation‐induced kidney damage – Kerstin Brinkmann, Paul Waring, Stefan P Glaser, Verena Wimmer, Denny L Cottle, Ming Shen Tham, Duong Nhu, Lachlan Whitehead, Alex RD Delbridge, Guillaume Lessene, Ian M Smyth, Marco J Herold, Gemma L Kelly, Stephanie Grabow, Andreas Strasser. https://www.embopress.org/doi/abs/10.15252/embj.2020105561
 
BCL(X)L and BCL2 increase the metabolic fitness of breast cancer cells: a single-cell imaging study – Lucantoni F, Salvucci M, Düssmann H, Lindner AU, Lambrechts D, Prehn JHM. https://www.nature.com/articles/s41418-020-00683-x

The Heme-regulated Inhibitor Pathway Modulates Susceptibility of Poor Prognosis B-Lineage Acute Leukemia to BH3-Mimetics – Kaitlyn Hill Smith, Amit Budhraja, John Lynch, Kathryn Roberts, John C Panetta, Jon Patrick Connelly, Meghan E Turnis, Shondra M Pruett-Miller, John D Schuetz, Charles G. Mullighan and Joseph T Opferman. https://mcr.aacrjournals.org/content/early/2020/12/05/1541-7786.MCR-20-0586.abstract
 
MCL-1 is essential for survival but dispensable for metabolic fitness of FOXP3+ regulatory T cells – Charis E. Teh, Alissa K. Robbins, Darren C. Henstridge, Grant Dewson, Sarah T. Diepstraten, Gemma Kelly, Mark A. Febbraio, Sarah S. Gabriel, Lorraine A. O’Reilly, Andreas Strasser and Daniel H. D. Gray. https://www.nature.com/articles/s41418-020-0585-1
 
AZD4320, A Dual Inhibitor of Bcl-2 and Bcl-xL, Induces Tumor Regression in Hematologic Cancer Models without Dose-limiting Thrombocytopenia – Srividya B. Balachander, Steven W. Criscione, Kate F. Byth, Justin Cidado, Ammar Adam, Paula Lewis, Terry Macintyre, Shenghua Wen, Deborah Lawson, Kathleen Burke, Tristan Lubinski, Jeffrey W. Tyner, Stephen E. Kurtz, Shannon K. McWeeney, Jeffrey Varnes, R. Bruce Diebold, Thomas Gero, Stephanos Ioannidis, Edward J. Hennessy, William McCoull, Jamal C. Saeh, Areya Tabatabai, Omid Tavana, Nancy Su, Alwin Schuller, Mathew J. Garnett, Patricia Jaaks, Elizabeth A. Coker, Gareth P. Gregory, Andrea Newbold, Ricky W. Johnstone, Eric Gangl, Martin Wild, Michael Zinda, J. Paul Secrist, Barry R. Davies, Stephen E. Fawell and Francis D. Gibbons. https://clincancerres.aacrjournals.org/content/26/24/6535
 

Death receptors


A Fas-4-1BB fusion protein converts a death to a pro-survival signal and enhances T cell therapy – Shannon K. Oda; Kristin G. Anderson; Pranali Ravikumar; Patrick Bonson; Nicolas M. Garcia ; Cody M. Jenkins; Summer Zhuang; Andrew W. Daman; Edison Y. Chiu; Breanna M. Bates ; Philip D. Greenberg. https://rupress.org/jem/article/217/12/e20191166/152059/A-Fas-4-1BB-fusion-protein-converts-a-death-to-a
 
Site‐specific ubiquitination of the E3 ligase HOIP regulates apoptosis and immune signaling – Lilian M Fennell, Carlos Gomez Diaz, Luiza Deszcz, Anoop Kavirayani, David Hoffmann, Kota Yanagitani, Alexander Schleiffer, Karl Mechtler, Astrid Hagelkruys, Josef Penninger, Fumiyo Ikeda. https://www.embopress.org/doi/abs/10.15252/embj.2019103303
 
Ubiquitination of RIPK1 regulates its activation mediated by TNFR1 and TLRs signaling in distinct manners – Xingyan Li, Mengmeng Zhang, Xinyue Huang, Wei Liang, Ganquan Li, Xiaojuan Lu, Yanxia Li, Heling Pan, Linyu Shi, Hong Zhu, Lihui Qian, Bing Shan and Junying Yuan. https://www.nature.com/articles/s41467-020-19935-y
 

Necroptosis


Locking mixed-lineage kinase domain-like protein in its auto-inhibited state prevents necroptosis – Martin Rübbelke, Dennis Fiegen, Margit Bauer, Florian Binder, James Hamilton, Jim King, Sven Thamm, Herbert Nar and Markus Zeeb. https://www.pnas.org/content/117/52/33272.abstract?etoc
 
Discovery of a Potent RIPK3 Inhibitor for the Amelioration of Necroptosis-Associated Inflammatory Injury – Kaijiang Xia , Fang Zhu, Chengkui Yang , Shuwei Wu, Yu Lin, Haikuo Ma, Xiaoliang Yu , Cong Zhao , Yuting Ji , Wenxiang Ge, Jingrui Wang , Yayun Du , Wei Zhang , Tao Yang , Xiaohu Zhang and Sudan He. https://www.frontiersin.org/articles/10.3389/fcell.2020.606119/full
 

Ferroptosis (or lipid synthesis)


Ferroptotic damage promotes pancreatic tumorigenesis through a TMEM173/STING-dependent DNA sensor pathway – Enyong Dai, Leng Han, Jiao Liu, Yangchun Xie, Herbert J. Zeh, Rui Kang, Lulu Bai and Daolin Tang. https://www.nature.com/articles/s41467-020-20154-8
 
Oncogenic activation of PI3K-AKT-mTOR signaling suppresses ferroptosis via SREBP-mediated lipogenesis – Junmei Yi, Jiajun Zhu, Jiao Wu, Craig B. Thompson, and Xuejun Jiang. https://www.pnas.org/content/117/49/31189.abstract?etoc
 
HCAR1/MCT1 Regulates Tumor Ferroptosis through the Lactate-Mediated AMPK-SCD1 Activity and Its Therapeutic Implications – Youbo Zhao, Menghuan Li, Xuemei Yao, Yang Fei, Zhenghong Lin, Zhengguo Li, Kaiyong Cai, Yanli Zhao, Zhong Luo. https://www.cell.com/cell-reports/fulltext/S2211-1247(20)31476-5 
 
3D Culture Models with CRISPR Screens Reveal Hyperactive NRF2 as a Prerequisite for Spheroid Formation via Regulation of Proliferation and Ferroptosis – Nobuaki Takahashi, Patricia Cho, Laura M. Selfors, Hendrik J. Kuiken, Roma Kaul, Takuro Fujiwara, Isaac S. Harris, Tian Zhang, Steven P. Gygi, Joan S. Brugge. https://www.cell.com/molecular-cell/fulltext/S1097-2765(20)30693-6
 

Miscellanous


The E3 ligase UBR2 regulates cell death under caspase deficiency via Erk/MAPK pathway – Elodie Villa, Rachel Paul, Ophélie Meynet, Sophie Volturo, Guillaume Pinna and Jean-Ehrland Ricci. https://www.nature.com/articles/s41419-020-03258-3
 
Apoptosis in the fetal testis eliminates developmentally defective germ cell clones – Daniel H. Nguyen, Bikem Soygur, Su-Ping Peng, Safia Malki, Guang Hu and Diana J. Laird. https://www.nature.com/articles/s41556-020-00603-8
 
Intracellular cathepsin C levels determine sensitivity of cells to leucyl‐leucine methyl ester‐triggered apoptosis – Nežka Kavčič, Miha Butinar, Barbara Sobotič, Maruša Hafner Česen, Ana Petelin, Lea Bojić, Tina Zavašnik Bergant, Andreja Bratovš, Thomas Reinheckel, Boris Turk. https://febs.onlinelibrary.wiley.com/doi/abs/10.1111/febs.15326
 
Plasma exosomal miR-375-3p regulates mitochondria-dependent keratinocyte apoptosis by targeting XIAP in severe drug-induced skin reactions – Chen Zhang , ZhenLai Zhu, JiXin Gao, LuTing Yang, ErLe Dang, Hui Fang, Shuai Shao, ShaoLong Zhang, ChunYing Xiao, Xu Yuan, Wei Li, Riichiro Abe, HongJiang Qiao, Gang Wang, Meng Fu. https://stm.sciencemag.org/content/12/574/eaaw6142
 

Reviews


Caspase-2 Substrates: To Apoptosis, Cell Cycle Control, and Beyond – Alexandra N. Brown-Suedel and Lisa Bouchier-Hayes. https://www.frontiersin.org/articles/10.3389/fcell.2020.610022/full
 
Pore formation in regulated cell death – Hector Flores‐Romero, Uris Ros, Ana J Garcia‐Saez. https://www.embopress.org/doi/full/10.15252/embj.2020105753
 
The Metabolic Underpinnings of Ferroptosis – Jiashuo Zheng, Marcus Conrad. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(20)30544-1
 

Comments


Mitochondria in Their Prime Drive Venetoclax Response in Acute Myeloid Leukemia – Mette C. Kriegbaum, Krister Wennerberg. https://www.cell.com/cancer-cell/fulltext/S1535-6108(20)30549-3?

Targeting MCL1 to induce mitophagy is a potential therapeutic strategy for Alzheimer disease – 
Xufeng Cen , Xiaoyan Xu and Hongguang Xia. https://www.tandfonline.com/doi/full/10.1080/15548627.2020.1860542

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