ApoList – November 2020


Bcl-2 family proteins


Reduced Mitochondrial Apoptotic Priming Drives Resistance to BH3 Mimetics in Acute Myeloid Leukemia – Shruti Bhatt, Marissa S. Pioso, Elyse Anne Olesinski, Binyam Yilma Jeremy A. Ryan, Thelma Mashaka, Buon Leutz, Sophia Adamia, Haoling Zhu, Yanan Kuang, Abhishek Mogili, Abner J. Louissaint, Stephan R. Bohl, Annette S. Kim, Anita K. Mehta, Sneha Sanghavi, Youzhen Wang, Erick Morris, Ensar Halilovic, Cloud P. Paweletz, David M. Weinstock, Jacqueline S. Garcia, Anthony Letai. https://www.sciencedirect.com/science/article/pii/S1535610820305419

Mcl-1 and Bok transmembrane domains: Unexpected players in the modulation of apoptosis – Estefanía Lucendo,  Mónica Sancho,  Fabio Lolicato,  Matti Javanainen,  Waldemar Kulig, Diego Leiva, Gerard Duart, Vicente Andreu-Fernández,  Ismael Mingarro and Mar Orzáez. https://www.pnas.org/content/early/2020/10/21/2008885117.abstract

Viral Bcl2s’ transmembrane domain interact with host Bcl2 proteins to control cellular apoptosis – Maria Jesús García-Murria, Gerard Duart, Brayan Grau, Elisabet Diaz-Beneitez, Dolores Rodríguez, Ismael Mingarro and Luis Martínez-Gil. https://www.nature.com/articles/s41467-020-19881-9

ELP-dependent expression of MCL1 promotes resistance to EGFR inhibition in triple-negative breast cancer cells – Peter Cruz-Gordillo, Megan E. Honeywell, Nicholas W. Harper, Thomas Leete, Michael J. Lee. https://stke.sciencemag.org/content/13/658/eabb9820

MCL1 binds and negatively regulates the transcriptional function of tumor suppressor p73 – Hayley Widden, Aneta Kaczmarczyk, Ashok Subedi, Robert H. Whitaker and William J. Placzek. https://www.nature.com/articles/s41419-020-03068-7

Mitofusin 2 but not mitofusin 1 mediates Bcl-XL-induced mitochondrial aggregation – Mengyan Du, Si Yu, Wenhua Su, Mengxin Zhao, Fangfang Yang, Yangpei Liu, Zihao Mai, Yong Wang, Xiaoping Wang and Tongsheng Chen. http://jcs.biologists.org/content/133/20/jcs245001?etoc

Pharmacological targeting of MCL-1 promotes mitophagy and improves disease pathologies in an Alzheimer’s disease mouse model – Xufeng Cen, Yanying Chen, Xiaoyan Xu, Ronghai Wu, Fusheng He, Qingwei Zhao, Qiming Sun, Cong Yi, Jie Wu, Ayaz Najafov and Hongguang Xia. https://www.nature.com/articles/s41467-020-19547-6

BCL-XL is an actionable target for treatment of malignant pleural mesothelioma – Surein Arulananda, Megan O’Brien, Marco Evangelista, Tiffany J. Harris, Nikita S. Steinohrt, Laura J. Jenkins, Marzena Walkiewicz, Robert J. J. O’Donoghue, Ashleigh R. Poh, Bibhusal Thapa, David S. Williams, Trishe Leong, John M. Mariadason, Xia Li, Jonathan Cebon, Erinna F. Lee, Thomas John and W. Douglas Fairlie. https://www.nature.com/articles/s41420-020-00348-1

Taxane-induced Attenuation of the CXCR2/BCL-2 Axis Sensitizes Prostate Cancer to Platinum-based Treatment – Vicenç Ruiz de Porras,  Xieng C. Wang, Luis Palomero, Mercedes Marin-Aguilera, Carme Solé-Blanch, Alberto Indacochea, Natalia Jimenez, Sara Bystrup, Martin Bakht, Vincenza Conteduca, Josep M. Piulats, Oscar Buisan, José F. Suarez, Juan Carlos Pardo, Elena Castro, David Olmos, Himisha Beltran, Begoña Mellado, Eva Martinez-Balibrea, Albert Font, Alvaro Aytes. https://www.europeanurology.com/article/S0302-2838(20)30778-8/fulltext#.X6CQKHJdwUM

Serine-70 phosphorylated Bcl-2 prevents oxidative stress-induced DNA damage by modulating the mitochondrial redox metabolism – Stephen Jun Fei Chong, Kartini Iskandar, Jolin Xiao Hui Lai, Jianhua Qu, Deepika Raman, Rebecca Valentin, Charles Herbaux, Mary Collins, Ivan Cherh Chiet Low, Thomas Loh, Matthew Davids, Shazib Pervaiz. https://academic.oup.com/nar/advance-article/doi/10.1093/nar/gkaa1110/6007660

LncRNA LHFPL3-AS1 contributes to tumorigenesis of melanoma stem cells via the miR-181a-5p/BCL2 pathway – Song Zhang, Haitao Wan and Xiaobo Zhang. https://www.nature.com/articles/s41419-020-03141-1


Death receptors


Inhibition of Glutamine Utilization Synergizes with Immune Checkpoint Inhibitor to Promote Antitumor Immunity – Jun-Kyu Byun, Mihyang Park, Seunghyeong Lee, Jae Won Yun, Jaebon Lee, Jae Sun Kim, Sung Jin Cho, Hui-Jeon Jeon, In-Kyu Lee, Yeon-Kyung Choi, Keun-Gyu Park. https://www.cell.com/molecular-cell/fulltext/S1097-2765(20)30722-X

Tumor Necrosis Factor Receptor-1 (p55) Deficiency Attenuates Tumor Growth and Intratumoral Angiogenesis and Stimulates CD8+ T Cell Function in Melanoma – Rodriguez YI, Campos LE, Castro MG, Bannoud N, Blidner AG, Filippa VP, Croci DO, Rabinovich GA, Alvarez SE. https://www.mdpi.com/2073-4409/9/11/2469


Caspases and IAPs


Caspase-8-dependent gasdermin D cleavage promotes antimicrobial defense but confers susceptibility to TNF-induced lethality – Benjamin Demarco , James P. Grayczyk, Elisabet Bjanes, Didier Le Roy, Wulf Tonnus, Charles-Antoine Assenmacher, Enrico Radaelli, Timothée Fettrelet, Vanessa Mack, Andreas Linkermann, Thierry Roger, Igor E. Brodsky, Kaiwen W. Chen, Petr Broz. https://advances.sciencemag.org/content/6/47/eabc3465

A regulatory region on RIPK2 is required for XIAP binding and NOD signaling activity – Valentin J Heim, Laura F Dagley, Che A Stafford, Fynn M Hansen, Elise Clayer, Aleksandra Bankovacki, Andrew I Webb, Isabelle S Lucet, John Silke, Ueli Nachbur. https://www.embopress.org/doi/abs/10.15252/embr.202050400

Molecular subtype-specific responses of colon cancer cells to the SMAC mimetic Birinapant – Michael Fichtner, Emir Bozkurt, Manuela Salvucci, Christopher McCann, Katherine A. McAllister, Luise Halang, Heiko Düssmann, Sinéad Kinsella, Nyree Crawford, Tamas Sessler, Daniel B. Longley and Jochen H. M. Prehn. https://www.nature.com/articles/s41419-020-03232-z


Necroptosis


Necroptosis restricts influenza A virus as a stand-alone cell death mechanism – Maria Shubina; Bart Tummers; David F. Boyd; Ting Zhang ; Chaoran Yin; Avishekh Gautam; Xi-zhi J. Guo; Diego A. Rodriguez; William J. Kaiser ; Peter Vogel; Douglas R. Green; Paul G. Thomas; Siddharth Balachandran. https://rupress.org/jem/article/217/11/e20191259/152023


Ferroptosis


Vaccination with early ferroptotic cancer cells induces efficient antitumor immunity – Iuliia Efimova, Elena Catanzaro, Louis Van der Meeren, Victoria D Turubanova, Hamida Hammad6, Tatiana A Mishchenko, Maria V Vedunova, Carmela Fimognari, Claus Bachert8, Frauke Coppieters, Steve Lefever, Andre G Skirtach, Olga Krysko and Dmitri V Krysko. https://jitc.bmj.com/content/8/2/e001369

Targeted reduction of cholesterol uptake in cholesterol-addicted lymphoma cells blocks turnover of oxidized lipids to cause ferroptosis – Jonathan S. Rink, Adam Lin, Kaylin M. McMahon, Andrea E Calvert, Shuo Yang, Tim Taxter, Jonathan Moreira, Amy Chadburn, Amir Behdad, Reem Karmali, C. Shad Thaxton and Leo I Gordon. http://www.jbc.org/content/early/2020/11/18/jbc.RA120.014888.abstract


Other forms of cell death


Ionizing radiation results in a mixture of cellular outcomes including mitotic catastrophe, senescence, methuosis, and iron-dependent cell death – Sandy Adjemian, Teodora Oltean, Sofie Martens, Bartosz Wiernicki, Vera Goossens, Tom Vanden Berghe, Benjamin Cappe, Maria Ladik, Franck B. Riquet, Liesbeth Heyndrickx, Jolien Bridelance, Marnik Vuylsteke, Katrien Vandecasteele and Peter Vandenabeele. https://www.nature.com/articles/s41419-020-03209-y


Miscellanous


Akt1 and dCIZ1 promote cell survival from apoptotic caspase activation during regeneration and oncogenic overgrowth – Gongping Sun, Xun Austin Ding, Yewubdar Argaw, Xiaoran Guo and Denise J. Montell. https://www.nature.com/articles/s41467-020-19068-2

Direct Tumor Killing and Immunotherapy through Anti-SerpinB9 Therapy – Liwei Jiang, Yi-Jun Wang, Jing Zhao, Mayuko Uehara, Qingming Hou, Vivek Kasinath, Takaharu Ichimura, Naima Banouni, Li Dai, Xiaofei Li, Dale L. Greiner, Leonard D. Shultz, Xiaolong Zhang, Zhen-Yu Jim Sun, Ian Curtin, Nicholas E. Vangos, Zoe C. Yeoh, Ezekiel A. Geffken, Hyuk-Soo Seo, Ze-Xian Liu, Gregory J. Heffron, Khalid Shah, Sirano Dhe-Paganon, Reza Abdi. https://www.cell.com/cell/fulltext/S0092-8674(20)31452-5

p53 deficiency triggers dysregulation of diverse cellular processes in physiological oxygen – Liz J. Valente; Amy Tarangelo; Albert Mao Li ; Marwan Naciri; Nitin Raj; Anthony M. Boutelle; Yang Li; Stephano Spano Mello ; Kathryn Bieging-Rolett; Ralph J. DeBerardinis; Jiangbin Ye; Scott J. Dixon; Laura D. Attardi. https://rupress.org/jcb/article/219/11/e201908212/152074

The 89-kDa PARP1 cleavage fragment serves as a cytoplasmic PAR carrier to induce AIF-mediated apoptosis – Masato Mashimo, Mayu Onishi, Arina Uno, Akari Tanimichi, Akari Nobeyama, Mana Mori, Sayaka Yamada, Shigeru Negi, Xiangning Bu, Jiro Kato, Joel Moss, Noriko Sanada, Ryoichi Kizu and Takeshi Fujii. http://www.jbc.org/content/early/2020/11/09/jbc.RA120.014479.abstract


Reviews


Targeting Bcl-2 Proteins in Acute Myeloid Leukemia – Yunxiong Wei, Yaqing Cao, Rui Sun, Lin Cheng, Xia Xiong, Xin Jin, Xiaoyuan He, Wenyi Lu, and Mingfeng Zhao. https://www.frontiersin.org/articles/10.3389/fonc.2020.584974/full

Interplay between caspase, Yes-associated protein, and mechanics: A possible switch between life and death? – Jessica Evangeline Tan Kabigting, Yusuke Toyama. https://www.sciencedirect.com/science/article/pii/S0955067420301459

Venetoclax-Based Combinations in Acute Myeloid Leukemia: Current Evidence and Future Directions – Bachar Samra, Marina Konopleva, Alessandro Isidori, Naval Daver, and Courtney DiNardo. https://www.frontiersin.org/articles/10.3389/fonc.2020.562558/full

The function and mechanism of ferroptosis in cancer – Ying Wang, Zihao Wei, Keran Pan, Jing Li, Qianming Chen. https://link.springer.com/article/10.1007/s10495-020-01638-w

TRAIL of Hope Meeting Resistance in Cancer – David Deng, Khalid Shah. https://www.cell.com/trends/cancer/fulltext/S2405-8033(20)30190-4

Detection of immunogenic cell death and its relevance for cancer therapy – Jitka Fucikova, Oliver Kepp, Lenka Kasikova, Giulia Petroni, Takahiro Yamazaki, Peng Liu, Liwei Zhao, Radek Spisek, Guido Kroemer and Lorenzo Galluzzi. https://www.nature.com/articles/s41419-020-03221-2

The caspase-3/GSDME signal pathway as a switch between apoptosis and pyroptosis in cancer – Mingxia Jiang, Ling Qi, Lisha Li and Yanjing Li. https://www.nature.com/articles/s41420-020-00349-0

Targeting BCL-2 in B-cell malignancies and overcoming therapeutic resistance – Isha Kapoor, Juraj Bodo, Brian T. Hill, Eric D. Hsi and Alexandru Almasan. https://www.nature.com/articles/s41419-020-03144-y


Comments


Caspase 2 and p53 Reunited in Tumor Control – Giulia Petroni, Ilio Vitale, Lorenzo Galluzzi. https://www.cell.com/trends/cell-biology/fulltext/S0962-8924(20)30168-9

Caspase-8 protein cuts a brake on immune defences – Igor E. Brodsky. https://www.nature.com/articles/d41586-020-02994-y

The interplay between apoptosis and ferroptosis mediated by ER stress – Go J. Yoshida. https://link.springer.com/article/10.1007/s10495-020-01641-1

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