Bcl-2 family proteins
Homogeneous Oligomers of Pro-apoptotic BAX Reveal Structural Determinants of Mitochondrial Membrane Permeabilization – Zachary J. Hauseman, Edward P. Harvey, Catherine E. Newman, Thomas E. Wales, Joel C. Bucci, Julian Mintseris, Devin K. Schweppe, Liron David, Lixin Fan, Daniel T. Cohen, Henry D. Herce, Rida Mourtada, Yael Ben-Nun, Noah B. Bloch, Scott B. Hansen, Hao Wu, Steven P. Gygi, John R. Engen, Loren D. Walensky. https://www.cell.com/molecular-cell/fulltext/S1097-2765(20)30349-X
Changes in Bcl-2 members in response to ibrutinib or venetoclax uncover functional hierarchy in determining resistance to venetoclax in CLL – Haselager MV, Kielbassa K, Ter Burg J, Bax DJC, Fernandes SM, Borst J, Tam C, Forconi F, Chiodin G, Brown JR, Dubois J, Kater AP, Eldering E. https://doi.org/10.1182/blood.2019004326
Caspase-1 cleaves Bid to release mitochondrial SMAC and drive secondary necrosis in the absence of GSDMD – Rosalie Heilig, Marisa Dilucca, Dave Boucher, Kaiwen W Chen, Dora Hancz, Benjamin Demarco, Kateryna Shkarina and Petr Broz. https://www.life-science-alliance.org/content/3/6/e202000735.abstract
5-Azacitidine Induces NOXA to Prime AML Cells for Venetoclax-Mediated Apoptosis – Sha Jin, Dan Cojocari, Julie J. Purkal, Relja Popovic, Nari N. Talaty, Yu Xiao, Larry R. Solomon, Erwin R. Boghaert, Joel D. Leverson and Darren C. Phillips. https://clincancerres.aacrjournals.org/content/26/13/3371
Spermine synthase and MYC cooperate to maintain colorectal cancer cell survival by repressing Bim expression – Yubin Guo, Qing Ye, Pan Deng, Yanan Cao, Daheng He, Zhaohe Zhou, Chi Wang, Yekaterina Y. Zaytseva, Charles E. Schwartz, Eun Y. Lee, B. Mark Evers, Andrew J. Morris, Side Liu and Qing-Bai She. https://www.nature.com/articles/s41467-020-17067-x
Characterization of an alternative BAK-binding site for BH3 peptides – Kaiqin Ye, Wei X. Meng, Hongbin Sun, Bo Wu, Meng Chen, Yuan-Ping Pang, Jia Gao, Hongzhi Wang, Junfeng Wang, Scott H. Kaufmann and Haiming Dai. https://www.nature.com/articles/s41467-020-17074-y
The chaperone Hsp70 is a BH3 receptor activated by the pro-apoptotic Bim to stabilize anti-apoptotic clients – Zongwei Guo, Ting Song, Ziqian Wang, Donghai Lin, Keke Cao, Peng Liu, Yingang Feng, Xiaodong Zhang, Peiran Wang and Zhichao Zhang. http://www.jbc.org/content/early/2020/07/10/jbc.RA120.013364.abstract
MARCH5 requires MTCH2 to coordinate proteasomal turnover of the MCL1:NOXA complex – Tirta Mario Djajawi, Lei Liu, Jia-nan Gong, Allan Shuai Huang, Ming-jie Luo, Zhen Xu, Toru Okamoto, Melissa J. Call, David C. S. Huang and Mark F. van Delft. https://www.nature.com/articles/s41418-020-0517-0
Death receptors
Engineering bacterial outer membrane vesicles as transdermal nanoplatforms for photo-TRAIL-programmed therapy against melanoma – Li-Hua Peng , Mao-Ze Wang, Yang Chu, Lei Zhang, Jie Niu, Hai-Tao Shao, Tie-Jun Yuan, Zhi-Hong Jiang, Jian-Qing Gao, Xing-Hai Ning. https://advances.sciencemag.org/content/6/27/eaba2735
Convergence of pathway analysis and pattern recognition predicts sensitization to latest generation TRAIL therapeutics by IAP antagonism – Vesna Vetma, Cristiano Guttà, Nathalie Peters, Christian Praetorius, Meike Hutt, Oliver Seifert, Friedegund Meier, Roland Kontermann, Dagmar Kulms and Markus Rehm. https://www.nature.com/articles/s41418-020-0512-5
The pseudo-caspase FLIP(L) regulates cell fate following p53 activation – Andrea Lees, Alexander J. McIntyre, Nyree T. Crawford, Fiammetta Falcone, Christopher McCann, Caitriona Holohan, Gerard P. Quinn, Jamie Z. Roberts, Tamas Sessler, Peter F. Gallagher, Gemma M. A. Gregg, Katherine McAllister, Kirsty M. McLaughlin, Wendy L. Allen, Laurence J. Egan, Aideen E. Ryan, Melissa J. Labonte-Wilson, Philip D. Dunne, Mark Wappett, Vicky M. Coyle, Patrick G. Johnston, Emma M. Kerr, Daniel B. Longley, and Simon S. McDade. https://www.pnas.org/content/117/30/17808.abstract?etoc
Necroptosis
Loss of RIPK3 does not impact MYC-driven lymphomagenesis or chemotherapeutic drug-induced killing of malignant lymphoma cells – Rachel Thijssen, Silvia Alvarez-Diaz, Clea Grace, Ming-yuan Gao, David H. Segal, Zhen Xu, Andreas Strasser and David C. S. Huang. https://www.nature.com/articles/s41418-020-0576-2
Pyroptosis
An Apoptotic Caspase Network Safeguards Cell Death Induction in Pyroptotic Macrophages – Nathalia Moraes de Vasconcelos, Nina Van Opdenbosch, Hanne Van Gorp, Rosa Martín-Pérez, Annalisa Zecchin, Peter Vandenabeele, Mohamed Lamkanfi. https://www.cell.com/cell-reports/fulltext/S2211-1247(20)30940-2
Caspase-1 Engages Full-Length Gasdermin D through Two Distinct Interfaces That Mediate Caspase Recruitment and Substrate Cleavage – Zhonghua Liu, Chuanping Wang, Jie Yang, Yinghua Chen, Bowen Zhou, Derek W. Abbott, Tsan Sam Xiao. https://www.cell.com/immunity/fulltext/S1074-7613(20)30237-5
Neutrophil Caspase-11 Is Essential to Defend against a Cytosol-Invasive Bacterium – Stephen B. Kovacs, Changhoon Oh, Vivien I. Maltez, Benjamin D. McGlaughon, Ambika Verma, Edward A. Miao, Youssef Aachoui. https://www.cell.com/cell-reports/fulltext/S2211-1247(20)30948-7
Ferroptosis and miscellaneous necrosis
Smac mimetics can provoke lytic cell death that is neither apoptotic nor necroptotic – Mark A. Miles, Sarah Caruso, Amy A. Baxter, Ivan K. H. Poon, Christine J. Hawkins. https://link.springer.com/article/10.1007/s10495-020-01610-8
Changes in ferrous iron and glutathione promote ferroptosis and frailty in aging Caenorhabditis elegans – Nicole L Jenkins, Simon A James, Agus Salim, Fransisca Sumardy, Terence P Speed, Marcus Conrad, Des R Richardson, Ashley I Bush , Gawain McColl. https://elifesciences.org/articles/56580
Hexokinase 2 displacement from mitochondria‐associated membranes prompts Ca2+‐dependent death of cancer cells – Francesco Ciscato, Riccardo Filadi, Ionica Masgras, Marco Pizzi, Oriano Marin, Nunzio Damiano, Paola Pizzo, Alessandro Gori, Federica Frezzato, Federica Chiara, Livio Trentin, Paolo Bernardi, Andrea Rasola. https://www.embopress.org/doi/full/10.15252/embr.201949117
Miscellanous
Kinetic Heterogeneity of Cancer Cell Fractional Killing – Zintis Inde, Giovanni C. Forcina, Kyle Denton, Scott J. Dixon. https://www.cell.com/cell-reports/fulltext/S2211-1247(20)30826-3
Flow cytometric detection of hyper-polarized mitochondria in regulated and accidental cell death processes – G. Warnes. https://link.springer.com/article/10.1007/s10495-020-01613-5
Reviews
Double agents of cell death: novel emerging functions of apoptotic regulators – Heather M. Lamb. https://febs.onlinelibrary.wiley.com/doi/full/10.1111/febs.15308
Rational design of genetically encoded reporter genes for optical imaging of apoptosis – Zhijing Xu, Yingzhuang Song, Fu Wang. https://link.springer.com/article/10.1007/s10495-020-01621-5
The mitochondrial permeability transition pore: Is it formed by the ATP synthase, adenine nucleotide translocators or both? – Christopher P. Baines, Manuel Gutiérrez-Aguilar. https://www.sciencedirect.com/science/article/abs/pii/S0005272820300992
Comments
Snapshot of a Deadly Embrace: The Caspase-1-GSDMD Interface – Lieselotte Vande Walle, Mohamed Lamkanfi. https://www.cell.com/immunity/fulltext/S1074-7613(20)30274-0
Memoriam – Beth Levine in memoriam. https://www.tandfonline.com/doi/full/10.1080/15548627.2020.1787721
