ApoList – June 2020


Bcl-2 family – biology


Endolysosomal Targeting of Mitochondria Is Integral to BAX-Mediated Mitochondrial Permeabilization during Apoptosis SignalingTim Sen Wang, Isabelle Coppens, Anna Saorin, Nathan Ryan Brady, Anne Hamacher-Brady. https://www.cell.com/developmental-cell/fulltext/S1534-5807(20)30403-2

MARCH5 mediates NOXA-dependent MCL1 degradation driven by kinase inhibitors and integrated stress response activationSeiji Arai, Andreas Varkaris, Mannan Nouri, Sen Chen, Lisha Xie, Steven P Balk. https://elifesciences.org/articles/54954

BIF-1 inhibits both mitochondrial and glycolytic ATP production: its downregulation promotes melanoma growthŽiva Frangež, Yuniel Fernández-Marrero, Darko Stojkov, S. Morteza Seyed Jafari, Robert E. Hunger, Valentin Djonov, Carsten Riether and Hans-Uwe Simon. https://www.nature.com/articles/s41388-020-1339-8

Pro-death signaling of cytoprotective heat shock factor 1: upregulation of NOXA leading to apoptosis in heat-sensitive cellsPatryk Janus, Agnieszka Toma-Jonik, Natalia Vydra, Katarzyna Mrowiec, Joanna Korfanty, Marek Chadalski, Piotr Widłak, Karolina Dudek, Anna Paszek, Marek Rusin, Joanna Polańska and Wiesława Widłak. https://www.nature.com/articles/s41418-020-0501-8

Glucocorticoids can induce BIM to trigger apoptosis in the absence of BAX and BAK1Li Dong and David L. Vaux. https://www.nature.com/articles/s41419-020-2599-5

The pro-survival Bcl-2 family member A1 delays spontaneous and FAS ligand-induced apoptosis of activated neutrophilsRobyn L. Schenk, Lahiru Gangoda, Kate E. Lawlor, Lorraine A. O’Reilly, Andreas Strasser and Marco J. Herold. https://www.nature.com/articles/s41419-020-2676-9

Defective nucleotide-dependent assembly and membrane fusion in Mfn2 CMT2A variants improved by BaxNyssa B Samanas, Emily A Engelhart and Suzanne Hoppins. https://www.life-science-alliance.org/content/3/5/e201900527.abstract


BH3 proteins and cancer


Failed Apoptosis Enhances Melanoma Cancer Cell AggressivenessKevin Berthenet, Camila Castillo Ferrer, Deborah Fanfone, Nikolay Popgeorgiev, David Neves, Philippe Bertolino, Benjamin Gibert, Hector Hernandez-Vargas, Gabriel Ichim. https://www.cell.com/cell-reports/fulltext/S2211-1247(20)30711-7

High-throughput dynamic BH3 profiling may quickly and accurately predict effective therapies in solid tumorsPatrick D. Bhola , Eman Ahmed, Jennifer L. Guerriero, Ewa Sicinska, Emily Su, Elizaveta Lavrova, Jing Ni, Otari Chipashvili, Timothy Hagan, Marissa S. Pioso, Kelley McQueeney, Kimmie Ng, Andrew J. Aguirre, James M. Cleary, David Cocozziello, Alaba Sotayo, Jeremy Ryan, Jean J. Zhao, Anthony Letai. https://stke.sciencemag.org/content/13/636/eaay1451

MCL1 inhibitors S63845/MIK665 plus Navitoclax synergistically kill difficult-to-treat melanoma cellsNabanita Mukherjee, Jenette Skees, Kaleb J. Todd, Drake A. West, Karoline A. Lambert, William A. Robinson, Carol M. Amato, Kasey L. Couts, Robert Van Gulick, Morgan MacBeth, Kelsey Nassar, Aik-Choon Tan, Zili Zhai, Mayumi Fujita, Stacey M. Bagby, Chiara R. Dart, James R. Lambert, David A. Norris and Yiqun G. Shellman. https://www.nature.com/articles/s41419-020-2646-2

BIK drives an aggressive breast cancer phenotype through sublethal apoptosis and predicts poor prognosis of ER-positive breast cancerVrajesh Pandya, John Maringa Githaka, Namrata Patel, Richard Veldhoen, Judith Hugh, Sambasivarao Damaraju, Todd McMullen, John Mackey and Ing Swie Goping. https://www.nature.com/articles/s41419-020-2654-2

Deep profiling of apoptotic pathways with mass cytometry identifies a synergistic drug combination for killing myeloma cellsCharis E. Teh, Jia-Nan Gong, David Segal, Tania Tan, Cassandra J. Vandenberg et al. https://www.nature.com/articles/s41418-020-0498-z


DISC


Caspase-8-Dependent Inflammatory Responses Are Controlled by Its Adaptor, FADD, and NecroptosisBart Tummers, Luigi Mari, Clifford S. Guy, Bradlee L. Heckmann, Diego A. Rodriguez, Sebastian Rühl, Julien Moretti, Jeremy Chase Crawford, Patrick Fitzgerald, Thirumala-Devi Kanneganti, Laura J. Janke, Stephane Pelletier, J. Magarian Blander, Douglas R. Green. https://www.cell.com/immunity/fulltext/S1074-7613(20)30168-0

FADD and Caspase-8 Regulate Gut Homeostasis and Inflammation by Controlling MLKL- and GSDMD-Mediated Death of Intestinal Epithelial CellsRobin Schwarzer, Huipeng Jiao, Laurens Wachsmuth, Achim Tresch, Manolis Pasparakis. https://www.cell.com/immunity/fulltext/S1074-7613(20)30160-6

Dissecting DISC regulation via pharmacological targeting of caspase-8/c-FLIPL heterodimerLaura K. Hillert, Nikita V. Ivanisenko, Denise Busse, Johannes Espe, Corinna König, Sergey E. Peltek, Nikolai A. Kolchanov, Vladimir A. Ivanisenko and Inna N. Lavrik. https://www.nature.com/articles/s41418-020-0489-0

Cytomegalovirus inhibition of extrinsic apoptosis determines fitness and resistance to cytotoxic CD8 T cellsM. Zeeshan Chaudhry, Rosaely Casalegno-Garduno, Katarzyna M. Sitnik, Bahram Kasmapour, Ann-Kathrin Pulm, Ilija Brizic, Britta Eiz-Vesper, Andreas Moosmann, Stipan Jonjic, Edward S. Mocarski, and Luka Cicin-Sain. https://www.pnas.org/content/117/23/12961.abstract?etoc


Caspases and IAPs


Noncanonical inhibition of caspase-3 by a nuclear microRNA confers endothelial protection by autophagy in atherosclerosisDonato Santovito , Virginia Egea, Kiril Bidzhekov, Lucia Natarelli, André Mourão, Xavier Blanchet, Kanin Wichapong, Maria Aslani, Coy Brunßen, Michael Horckmans, Michael Hristov, Arie Geerlof, Esther Lutgens, Mat J.A.P. Daemen, Tilman Hackeng, Christian Ries, Triantafyllos Chavakis, Henning Morawietz, Ronald Naumann, Philipp von Hundelshausen, Sabine Steffens, Johan Duchêne, Remco T.A. Megens, Michael Sattler, Christian Weber. https://stm.sciencemag.org/content/12/546/eaaz2294

The Lumiptosome, an engineered luminescent form of the apoptosome can report cell death by using the same Apaf-1 dependent pathwayElaheh Sadat Hosseini, Maryam Nikkhah, Amir Ali Hamidieh, Howard O. Fearnhead, Jean-Paul Concordet and Saman Hosseinkhani. http://jcs.biologists.org/content/133/10/jcs242636?etoc

A small-molecule ARTS mimetic promotes apoptosis through degradation of both XIAP and Bcl-2Dana Mamriev, Ruqaia Abbas, Franca-Maria Klingler, Juliana Kagan, Nir Kfir, Alastair Donald, Keren Weidenfeld, David W. Sheppard, Dalit Barkan and Sarit Larisch. https://www.nature.com/articles/s41419-020-2670-2

XAF1 as a modifier of p53 function and cancer susceptibilityEmilia M. Pinto , Bonald C. Figueiredo, Wenan Chen […] Gang Wu, Gerard P. Zambetti. https://advances.sciencemag.org/content/6/26/eaba3231


Necroptosis and RIP kinases


MLKL trafficking and accumulation at the plasma membrane control the kinetics and threshold for necroptosisAndre L. Samson, Ying Zhang, Niall D. Geoghegan, Xavier J. Gavin, Katherine A. Davies, Michael J. Mlodzianoski, Lachlan W. Whitehead, Daniel Frank, Sarah E. Garnish, Cheree Fitzgibbon, Anne Hempel, Samuel N. Young, Annette V. Jacobsen, Wayne Cawthorne, Emma J. Petrie, Maree C. Faux, Kristy Shield-Artin, Najoua Lalaoui, Joanne M. Hildebrand, John Silke, Kelly L. Rogers, Guillaume Lessene, Edwin D. Hawkins and James M. Murphy. https://www.nature.com/articles/s41467-020-16887-1

Distinct pseudokinase domain conformations underlie divergent activation mechanisms among vertebrate MLKL orthologuesKatherine A. Davies, Cheree Fitzgibbon, Samuel N. Young, Sarah E. Garnish, Wayland Yeung, Diane Coursier, Richard W. Birkinshaw, Jarrod J. Sandow, Wil I. L. Lehmann, Lung-Yu Liang, Isabelle S. Lucet, James D. Chalmers, Wayne M. Patrick, Natarajan Kannan, Emma J. Petrie, Peter E. Czabotar and James M. Murphy. https://www.nature.com/articles/s41467-020-16823-3

RIPK3 upregulation confers robust proliferation and collateral cystine-dependence on breast cancer recurrenceChao-Chieh Lin, Nathaniel W. Mabe, Yi-Tzu Lin, Wen-Hsuan Yang, Xiaohu Tang, Lisa Hong, Tianai Sun, Jeremy Force, Jeffrey R. Marks, Tso-Pang Yao, James V. Alvarez and Jen-Tsan Chi. https://www.nature.com/articles/s41418-020-0499-y

Hepatocyte-specific TAK1 deficiency drives RIPK1 kinase-dependent inflammation to promote liver fibrosis and hepatocellular carcinomaShuixia Tan, Jing Zhao, Ziyu Sun, Shuangyi Cao, Kongyan Niu, Yedan Zhong, Han Wang, Linyu Shi, Heling Pan, Junhao Hu, Lihui Qian, Nan Liu, and Junying Yuan. https://www.pnas.org/content/117/25/14231.abstract?etoc


Pyroptosis


FDA-approved disulfiram inhibits pyroptosis by blocking gasdermin D pore formationJun Jacob Hu, Xing Liu, Shiyu Xia, Zhibin Zhang, Ying Zhang, Jingxia Zhao, Jianbin Ruan, Xuemei Luo, Xiwen Lou, Yang Bai, Junhong Wang, L. Robert Hollingsworth, Venkat Giri Magupalli, Li Zhao, Hongbo R. Luo, Justin Kim, Judy Lieberman and Hao Wu. https://www.nature.com/articles/s41590-020-0669-6

Induction of ASC pyroptosis requires gasdermin D or caspase-1/11-dependent mediators and IFNβ from pyroptotic macrophagesCuiping Zhang, Caiqi Zhao, Xiaoyan Chen, Rujia Tao, Sijiao Wang, Guangxun Meng, Xing Liu, Changzhou Shao and Xiao Su. https://www.nature.com/articles/s41419-020-2664-0

Extended subsite profiling of the pyroptosis effector protein gasdermin D reveals a region recognized by inflammatory caspase-11Betsaida Bibo-Verdugo, Scott J Snipas, Sonia Kolt, Marcin Poreba and Guy S Salvesen. http://www.jbc.org/content/early/2020/06/18/jbc.RA120.014259.abstract


Miscellanous


Senescence, Necrosis, and Apoptosis Govern Circulating Cell-free DNA Release KineticsAriana Rostami, Meghan Lambie, Caberry W. Yu, Vuk Stambolic, John N. Waldron, Scott V. Bratman. https://www.cell.com/cell-reports/fulltext/S2211-1247(20)30811-1

The anti-cancer drug ABTL0812 induces ER stress-mediated cytotoxic autophagy by increasing dihydroceramide levels in cancer cellsPau Muñoz-Guardiola, Josefina Casas, Elisabet Megías-Roda, Sònia Solé, Héctor Perez-Montoyo, Marc Yeste-Velasco, Tatiana Erazo, Nora Diéguez-Martínez, Sergio Espinosa-Gil, Cristina Muñoz-Pinedo, Guillermo Yoldi, Jose L Abad, Miguel F Segura, Teresa Mora, Margarita Romeo, Joaquim Bosch-Barrera, Ana Oaknin, Jose Alfón, Carles Domènech, Gemma Fabriàs, Guillermo Velasco and Jose M Lizcano. https://www.tandfonline.com/doi/full/10.1080/15548627.2020.1761651

Hexokinase II dissociation alone cannot account for changes in heart mitochondrial function, morphology and sensitivity to permeability transition pore opening following ischemiaGonçalo C Pereira, Laura Lee, Nadiia Rawlings, Joke Ouwendijk, Joanne E Parker, Tatyana N Andrienko, Jeremy M Henley, Andrew P Halestrap. https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0234653


Reviews


The clearance of dead cells by efferocytosisEmilio Boada-Romero, Jennifer Martinez, Bradlee L. Heckmann and Douglas R. Green. https://www.nature.com/articles/s41580-020-0232-1

Cell Death in the Origin and Treatment of CancerAndreas Strasser, David L. Vaux. https://www.cell.com/molecular-cell/fulltext/S1097-2765(20)30315-4

Noncanonical Cell Fate Regulation by Bcl-2 ProteinsStephen Jun Fei Chong, Saverio Marchi, Giulia Petroni, Guido Kroemer, Lorenzo Galluzzi, Shazib Pervaiz. https://www.cell.com/trends/cell-biology/fulltext/S0962-8924(20)30070-2

Photodynamic therapy: autophagy and mitophagy, apoptosis and paraptosisDavid Kessel and John J. Reiners. https://www.tandfonline.com/doi/abs/10.1080/15548627.2020.1783823

Uncovering the PIDDosome and caspase-2 as regulators of organogenesis and cellular differentiationValentina C. Sladky and Andreas Villunger. https://www.nature.com/articles/s41418-020-0556-6


Comments / other


Caspase-8 and FADD: Where Cell Death and Inflammation CollideMarcelo Pires Amaral, Karina Ramalho Bortoluci. https://www.cell.com/immunity/fulltext/S1074-7613(20)30216-8

Deadly Encounter: Endosomes Meet Mitochondria to Initiate ApoptosisMariella Vicinanza, David C. Rubinsztein. https://www.cell.com/developmental-cell/fulltext/S1534-5807(20)30419-6

Pyroptosis Takes Aim at NeurodevelopmentJaeda C. Coutinho-Budd, Heather T. Broihier. https://www.cell.com/developmental-cell/fulltext/S1534-5807(20)30402-0

Regulating RIPK1: another way in which ULK1 contributes to survivalWenxian Wu and Björn Stork. https://www.tandfonline.com/doi/full/10.1080/15548627.2020.1783110

MLKL contributes to Western diet-induced liver injury through inhibiting autophagyXiaoqin Wu and Laura E. Nagy. https://www.tandfonline.com/doi/abs/10.1080/15548627.2020.1760624

Cell death through the ages: The ICDS 25th Anniversary MeetingJarvier N. Mohammed, Jesse D. Gelles, Camila RubioPatiño, Madhavika N. Serasinghe, Andrew P. Trotta, Richard A. Lockshin, Zahra Zakeri, Jerry E. Chipuk. https://febs.onlinelibrary.wiley.com/doi/abs/10.1111/febs.15252

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