ApoList – May 2020


Bcl-2 family proteins


Identification of a Covalent Molecular Inhibitor of Anti-apoptotic BFL-1 by Disulfide Tethering – Edward P. Harvey, Zachary J. Hauseman, Daniel T. Cohen, T. Justin Rettenmaier, Susan Lee, Annissa J. Huhn, Thomas E. Wales, Hyuk-Soo Seo, James Luccarelli, Catherine E. Newman, Rachel M. Guerra, Gregory H. Bird, Sirano Dhe-Paganon, John R. Engen, James A. Wells, Loren D. Walensky. https://www.cell.com/cell-chemical-biology/fulltext/S2451-9456(20)30118-5?sf233998513=1

BCL-2 antagonism sensitizes cytotoxic T cell–resistant HIV reservoirs to elimination ex vivo – Yanqin Ren, Szu Han Huang, Shabnum Patel, Winiffer D. Conce Alberto, Dean Magat, Dughan Ahimovic, Amanda B. Macedo, Ryan Durga, Dora Chan, Elizabeth Zale, Talia M. Mota, Ronald Truong, Thomas Rohwetter, Chase D. McCann, Colin M. Kovacs, Erika Benko, Avery Wimpelberg, Christopher Cannon, W. David Hardy, Alberto Bosque, Catherine M. Bollard, and R. Brad Jones. https://www.jci.org/articles/view/132374


Death receptors


Quantitative single‐molecule imaging of TNFR1 reveals zafirlukast as antagonist of TNFR1 clustering and TNFα‐induced NF‐ĸB signaling – Nadine Weinelt, Christos Karathanasis, Sonja Smith, Juliane Medler, Sebastian Malkusch, Simone Fulda, Harald Wajant, Mike Heilemann, Sjoerd J. L. van Wijk. https://jlb.onlinelibrary.wiley.com/doi/10.1002/JLB.2AB0420-572RR#.XrvxctJyfu8.twitter

Doxorubicin sensitizes cancer cells to Smac mimetic via synergistic activation of the CYLD/RIPK1/FADD/caspase-8-dependent apoptosis – Chengkui Yang, Qiao Ran, Yifei Zhou, Shan Liu, Cong Zhao, Xiaoliang Yu, Fang Zhu, Yuting Ji, Qian Du, Tao Yang, Wei Zhang and Sudan He. https://link.springer.com/article/10.1007/s10495-020-01604-6


Caspases


Non-Canonical Caspase Activity Antagonizes p38 MAPK Stress-Priming Function to Support Development – Benjamin P. Weaver, Yi M. Weaver, Shizue Omi, Wang Yuan, Jonathan J. Ewbank, Min Han. https://www.cell.com/developmental-cell/fulltext/S1534-5807(20)30224-0

Leishmania aethiopica cell‐to‐cell spreading involves caspase‐3, AkT, and NF‐κB but not PKC‐δ activation and involves uptake of LAMP‐1‐positive bodies containing parasites – Medhavi Ranatunga, Rajeev Rai, Simon C. W. Richardson, Paul Dyer, Laurence Harbige, Andrew Deacon, Lauren Pecorino, Giulia T. M. Getti. https://febs.onlinelibrary.wiley.com/doi/abs/10.1111/febs.15166

Involvement of CASP9 (caspase 9) in IGF2R/CI-MPR endosomal transport – Jie Han, Leslie A. Goldstein, Wen Hou, Simon C. Watkins and Hannah Rabinowich. https://www.tandfonline.com/doi/abs/10.1080/15548627.2020.1761742


Necroptosis


The death-inducing activity of RIPK1 is regulated by the pH environment – Kenta Moriwaki , Sakthi Balaji, Francis Ka-Ming Chan. https://stke.sciencemag.org/content/13/631/eaay7066

Crucial Roles of the RIP Homotypic Interaction Motifs of RIPK3 in RIPK1-Dependent Cell Death and Lymphoproliferative Disease – Haiwei Zhang, Xiaoxia Wu, Xiaoming Li, Ming Li, Fang Li, Lingxia Wang, Xixi Zhang, Yue Zhang, Yan Luo, Hui Wang, Yiguo Jiang, Haibing Zhang. https://www.cell.com/cell-reports/fulltext/S2211-1247(20)30603-3

The Zα2 domain of ZBP1 is a molecular switch regulating influenza-induced PANoptosis and perinatal lethality during development – Sannula Kesavardhana, R. K. Subbarao Malireddi, Amanda R Burton, Shaina N Porter, Peter Vogel, Shondra M Pruett-Miller and Thirumala-Devi Kanneganti. http://www.jbc.org/content/early/2020/04/29/jbc.RA120.013752.abstract

Attenuated Epigenetic Suppression of Muscle Stem Cell Necroptosis Is Required for Efficient Regeneration of Dystrophic Muscles – Krishnamoorthy Sreenivasan, Alessandro Ianni, Carsten Künne, Boris Strilic, Stefan Günther, Eusebio Perdiguero, Marcus Krüger, Simone Spuler, Stefan Offermanns, Pablo Gómez-del Arco, Juan Miguel Redondo, Pura Munoz-Canoves, Johnny Kim, Thomas Braun. https://www.cell.com/cell-reports/fulltext/S2211-1247(20)30605-7


Pyroptosis


Granzyme A from cytotoxic lymphocytes cleaves GSDMB to trigger pyroptosis in target cells – Zhiwei Zhou, Huabin He, Kun Wang, Xuyan Shi, Yupeng Wang, Ya Su, Yao Wang, Da Li, Wang Liu, Yongliang Zhang, Lianjun Shen, Weidong Han, Lin Shen, Jingjin Ding, Feng Shao. https://science.sciencemag.org/content/368/6494/943?utm


Miscellanous


Zika virus noncoding RNA suppresses apoptosis and is required for virus transmission by mosquitoes – Andrii Slonchak, Leon E. Hugo, Morgan E. Freney, Sonja Hall-Mendelin, Alberto A. Amarilla, Francisco J. Torres, Yin Xiang Setoh, Nias Y. G. Peng, Julian D. J. Sng, Roy A. Hall, Andrew F. van den Hurk, Gregor J. Devine and Alexander A. Khromykh. https://www.nature.com/articles/s41467-020-16086-y

CXCR1 and CXCR2 Chemokine Receptor Agonists Produced by Tumors Induce Neutrophil Extracellular Traps that Interfere with Immune CytotoxicityÁlvaro Teijeira, Saray Garasa, María Gato, Carlos Alfaro, Itziar Migueliz, Assunta Cirella, Carlos de Andrea, Maria Carmen Ochoa, Itziar Otano, Iñaki Etxeberria, Maria Pilar Andueza, Celia P. Nieto, Leyre Resano, Arantza Azpilikueta, Marcello Allegretti, Maria de Pizzol, Mariano Ponz-Sarvisé, Ana Rouzaut, Miguel F. Sanmamed, Kurt Schalper, Michael Carleton, Mario Mellado, María E. Rodriguez-Ruiz, Pedro Berraondo, Jose L. Perez-Gracia, Ignacio Melero. https://www.cell.com/immunity/fulltext/S1074-7613(20)30089-3


Reviews


BCL-2 family deregulation in colorectal cancer: potential for BH3 mimetics in therapy – Prashanthi Ramesh and Jan Paul Medema. https://link.springer.com/article/10.1007/s10495-020-01601-9

Emerging Mechanisms and Disease Relevance of Ferroptosis – Brent R. Stockwell, Xuejun Jiang, Wei Gu. https://www.cell.com/trends/cell-biology/fulltext/S0962-8924(20)30054-4

BAX inhibitor‐1: between stress and survival – Cynthia Lebeaupin, Marina Blanc, Déborah Vallée, Harald Keller, Béatrice Bailly‐Maitre. https://febs.onlinelibrary.wiley.com/doi/abs/10.1111/febs.15179

The emerging role of paraptosis in tumor cell biology: Perspectives for cancer prevention and therapy with natural compoundsFabrizio Fontana, Michela Raimondi, Monica Marzagalli, Alessandro Di Domizio, Patrizia Limonta. https://www.sciencedirect.com/science/article/abs/pii/S0304419X19301945

Caspase-8: The double-edged sword – Ranadip Mandal, Joan Compte Barrón, Izabela Kostova, Sven Becker, Klaus Strebhardt. https://www.sciencedirect.com/science/article/abs/pii/S0304419X19301763

New insights into the regulation of apoptosis, necroptosis, and pyroptosis by receptor interacting protein kinase 1 and caspase-8Robin Schwarzer, Lucie Laurien, Manolis Pasparakis. https://www.sciencedirect.com/science/article/abs/pii/S0955067420300272?dgcid=raven_sd_via_email

The Role of Caspase-2 in Regulating Cell Fate – Vasanthy Vigneswara and Zubair Ahmed. https://www.mdpi.com/2073-4409/9/5/1259

Inhibition of Anti-Apoptotic Bcl-2 Proteins in Preclinical and Clinical Studies: Current Overview in CancerSimona D’Aguanno and Donatella Del Bufalo. https://www.mdpi.com/2073-4409/9/5/1287

Tumour Cell Secretome in Chemoresistance and Tumour Recurrence – Emma C. Madden, Adrienne M. Gorman, Susan E. Logue, Afshin Samali. https://www.cell.com/trends/cancer/fulltext/S2405-8033(20)30081-9

Novel Forms of Immunomodulation for Cancer TherapyAlfonso Serrano-del Valle, Javier Naval, Alberto Anel, Isabel Marzo. https://www.cell.com/trends/cancer/fulltext/S2405-8033(20)30076-5

Cysteine Depletion, a Key Action to Challenge Cancer Cells to Ferroptotic Cell Death – Daher B, Vučetić M, Pouysségur J. https://www.frontiersin.org/articles/10.3389/fonc.2020.00723/full

SnapShot: Ferroptosis – Kamyar Hadian, Brent R. Stockwell. https://www.cell.com/cell/fulltext/S0092-8674(20)30504-3


Comments


Development or Disease: Caspases Balance Growth and Immunity in C. elegans – Olya Yarychkivska, Shai Shaham. https://www.cell.com/developmental-cell/fulltext/S1534-5807(20)30273-2

Killer cells add fire to fuel immunotherapy – Christopher J. Nicolai, David H. Raulet. https://science.sciencemag.org/content/368/6494/943

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