ApoList – April 2020


Bcl-2 family proteins


Separase-triggered apoptosis enforces minimal length of mitosis – Susanne Hellmuth, Olaf Stemmann. https://www.nature.com/articles/s41586-020-2187-y

The apoptosis inhibitor Bcl-xL controls breast cancer cell migration through mitochondria-dependent reactive oxygen species production – Margaux Bessou, Jonathan Lopez, Rudy Gadet, Mathieu Deygas, Nikolay Popgeorgiev, Delphine Poncet, Adrien Nougarède, Pauline Billard, Ivan Mikaelian, Philippe Gonzalo, Ruth Rimokh and Germain Gillet. https://www.nature.com/articles/s41388-020-1212-9

Melanoma-specific bcl-2 promotes a protumoral M2-like phenotype by tumor-associated macrophagesMarta Di Martile, Valentina Farini, Francesca Maria Consonni, Daniela Trisciuoglio, Marianna Desideri, Elisabetta Valentini, Simona D’Aguanno, Maria Grazia Tupone, Simonetta Buglioni, Cristiana Ercolani, Enzo Gallo, Bruno Amadio, Irene Terrenato, Maria Laura Foddai, Antonio Sica and Donatella Del Bufalo. https://jitc.bmj.com/content/8/1/e000489

Loss of BIM in T cells results in BCL-2 family BH3-member compensation but incomplete cell death sensitivity normalization – Lindsey M. Ludwig, Lauren E. Roach, Samuel G. Katz and James L. LaBelle. https://link.springer.com/article/10.1007/s10495-020-01593-6

Inhibition of BCL2 Family Members Increases the Efficacy of Copper Chelation in BRAFV600E-Driven Melanoma – Ye-Jin Kim, Tiffany Tsang, Grace R. Anderson, Jessica M. Posimo and Donita C. Brady. https://cancerres.aacrjournals.org/content/80/7/1387

Monocytic Subclones Confer Resistance to Venetoclax-Based Therapy in Patients with Acute Myeloid Leukemia – Shanshan Pei, Daniel A. Pollyea, Annika Gustafson, Brett M. Stevens, Mohammad Minhajuddin, Rui Fu, Kent A. Riemondy, Austin E. Gillen, Ryan M. Sheridan, Jihye Kim, James C. Costello, Maria L. Amaya, Anagha Inguva, Amanda Winters, Haobin Ye, Anna Krug, Courtney L. Jones, Biniam Adane, Nabilah Khan, Jessica Ponder, Jeffrey Schowinsky, Diana Abbott, Andrew Hammes, Jason R. Myers, John M. Ashton, Travis Nemkov, Angelo D’Alessandro, Jonathan A. Gutman, Haley E. Ramsey, Michael R. Savona, Clayton A. Smith and Craig T. Jordan. https://cancerdiscovery.aacrjournals.org/content/10/4/536

The senotherapeutic drug ABT-737 disrupts aberrant p21 expression to restore liver regeneration in adult mice – Birgit Ritschka, Tania Knauer-Meyer, Daniel Sampaio Gonçalves, Alba Mas, Jean-Luc Plassat, Matej Durik, Hugues Jacobs, Elisa Pedone, Umberto Di Vicino, Maria Pia Cosma and William M. Keyes. http://genesdev.cshlp.org/content/34/7-8/489.abstract?etoc


Death receptors


Impaired Death Receptor Signaling in Leukemia Causes Antigen-Independent Resistance by Inducing CAR T-cell Dysfunction – Nathan Singh, Yong Gu Lee, Olga Shestova, Pranali Ravikumar, Katharina E. Hayer, Seok Jae Hong, Xueqing Maggie Lu, Raymone Pajarillo, Sangya Agarwal, Shunichiro Kuramitsu, Elena J. Orlando, Karen Thudium Mueller, Charly R. Good, Shelley L. Berger, Ophir Shalem, Matthew D. Weitzman, Noelle V. Frey, Shannon L. Maude, Stephan A. Grupp, Carl H. June, Saar Gill and Marco Ruella. https://cancerdiscovery.aacrjournals.org/content/10/4/552

Blocking the death checkpoint protein TRAIL improves cardiac function after myocardial infarction in monkeys, pigs, and rats – Yaohui Wang , Hailong Zhang, Zhizeng Wang, Yinxiang Wei, Mingli Wang, Meichen Liu, Xuance Wang, Yinan Jiang, Gongning Shi, Dongmei Zhao, Zhengyan Yang, Zhiguang Ren, Jing Li, Zhenkai Zhang, Zhenfeng Wang, Bei Zhang, Beibei Zong, Xueke Lou, Chengguo Liu, Zihui Wang, Hao Zhang, Ningya Tao, Xuefang Li, Xingkun Zhang, Yafei Guo, Yang Ye, Yu Qi, Hui Li, Man Wang, Rongxin Guo, Guanchang Cheng, Shulian Li, Jun Zhang, Guangchao Liu, Lihui Chai, Qiang Lou, Xia Li, Xiukun Cui, Erhe Gao, Zheng Dong, Yanzhong Hu, Youhai H. Chen, Yuanfang Ma. https://stm.sciencemag.org/content/12/540/eaaw3172

A Two-Cell Model for IL-1β Release Mediated by Death-Receptor Signaling – Carlos A. Donado, Anh B. Cao, Daimon P. Simmons, Ben A. Croker, Patrick J. Brennan, Michael B. Brenner. https://www.cell.com/cell-reports/fulltext/S2211-1247(20)30344-2

Dynamic Fas signaling network regulates neural stem cell proliferation and memory enhancement – Seokhwi Kim , Nury Kim, Jinsu Lee, Sungsoo Kim, Jongryul Hong, Seungkyu Son, Won Do Heo. https://advances.sciencemag.org/content/6/17/eaaz9691


Necroptosis and RIP kinases


Identification of MLKL membrane translocation as a checkpoint in necroptotic cell death using Monobodies – Emma J. Petrie, Richard W. Birkinshaw, Akiko Koide, Eric Denbaum, Joanne M. Hildebrand, Sarah E. Garnish, Katherine A. Davies, Jarrod J. Sandow, Andre L. Samson, Xavier Gavin, Cheree Fitzgibbon, Samuel N. Young, Patrick J. Hennessy, Phoebe P. C. Smith, Andrew I. Webb, Peter E. Czabotar, Shohei Koide, and James M. Murphy. https://www.pnas.org/content/117/15/8468.abstract?etoc

The Autophagy-Initiating Kinase ULK1 Controls RIPK1-Mediated Cell Death – Wenxian Wu, Xiaojing Wang, Niklas Berleth, Jana Deitersen, Nora Wallot-Hieke, Philip Böhler, David Schlütermann, Fabian Stuhldreier, Jan Cox, Katharina Schmitz, Sabine Seggewiß, Christoph Peter, Gary Kasof, Anja Stefanski, Kai Stühler, Astrid Tschapek, Axel Gödecke, Björn Stork. https://www.cell.com/cell-reports/fulltext/S2211-1247(20)30457-5

Autophosphorylation at serine 166 regulates RIP kinase 1-mediated cell death and inflammation – Lucie Laurien, Masahiro Nagata, Hannah Schünke, Tom Delanghe, Janica L. Wiederstein, Snehlata Kumari, Robin Schwarzer, Teresa Corona, Marcus Krüger, Mathieu J. M. Bertrand, Vangelis Kondylis and Manolis Pasparakis. https://www.nature.com/articles/s41467-020-15466-8


Caspases / Pyroptosis


Caspase-6 Is a Key Regulator of Innate Immunity, Inflammasome Activation, and Host Defense – Min Zheng, Rajendra Karki, Peter Vogel, Thirumala-Devi Kanneganti. https://www.cell.com/cell/fulltext/S0092-8674(20)30333-0

A Two-Cell Model for IL-1β Release Mediated by Death-Receptor Signaling – Carlos A. Donado, Anh B. Cao, Daimon P. Simmons, Ben A. Croker, Patrick J. Brennan, Michael B. Brenner. https://www.cell.com/cell-reports/fulltext/S2211-1247(20)30344-2


Ferroptosis


Cysteine depletion induces pancreatic tumor ferroptosis in mice – Michael A. Badgley, Daniel M. Kremer, H. Carlo Maurer, Kathleen E. DelGiorno, Ho-Joon Lee, Vinee Purohit, Irina R. Sagalovskiy, Alice Ma, Jonathan Kapilian, Christina E. M. Firl, Amanda R. Decker, Steve A. Sastra, Carmine F. Palermo, Leonardo R. Andrade, Peter Sajjakulnukit, Li Zhang, Zachary P. Tolstyka, Tal Hirschhorn, Candice Lamb, Tong Liu, Wei Gu, E. Scott Seeley, Everett Stone, George Georgiou, Uri Manor, Alina Iuga, Geoffrey M. Wahl, Brent R. Stockwell, Costas A. Lyssiotis, Kenneth P. Olive. https://science.sciencemag.org/content/368/6486/85

MDM2 and MDMX promote ferroptosis by PPARα-mediated lipid remodeling – Divya Venkatesh, Nicholas A. O’Brien, Fereshteh Zandkarimi, David R. Tong, Michael E. Stokes, Denise E. Dunn, Everett S. Kengmana, Allegra T. Aron, Alyssa M. Klein, Joleen M. Csuka, Sung-Hwan Moon, Marcus Conrad, Christopher J. Chang, Donald C. Lo, Angelo D’Alessandro, Carol Prives and Brent R. Stockwell. http://genesdev.cshlp.org/content/34/7-8/526.abstract?etoc


Miscellanous


Cell death induced by cytotoxic CD8+ T cells is immunogenic and primes caspase-3–dependent spread immunity against endogenous tumor antigensPaula Jaime-Sanchez, Iratxe Uranga-Murillo, Nacho Aguilo, Sofia C Khouili, Maykel A Arias, David Sancho, Julian Pardo. https://jitc.bmj.com/content/8/1/e000528

Cellular cytotoxicity is a form of immunogenic cell deathLuna Minute, Alvaro Teijeira, Alfonso R Sanchez-Paulete, Maria C Ochoa, Maite Alvarez, Itziar Otano, Iñaki Etxeberrria, Elixabet Bolaños, Arantza Azpilikueta, Saray Garasa, Noelia Casares, Jose Luis Perez Gracia, Maria E Rodriguez-Ruiz, Pedro Berraondo and Ignacio Melero. https://jitc.bmj.com/content/8/1/e000325

A nonpeptidyl molecule modulates apoptosis-like cell death by inhibiting P. falciparum metacapase-2 – Vandana, Sudha Shankar, Kona Madhavinadha Prasad, Mohammad Kashif, Inderjeet Kalia, Rajkishor Rai, Agam P. Singh, Kailash C. Pandey. https://portlandpress.com/biochemj/article-abstract/477/7/1323/222446/

Starvation and antimetabolic therapy promote cytokine release and recruitment of immune cells – Franziska Püschel, Francesca Favaro, Jaime Redondo-Pedraza, Estefanía Lucendo, Raffaella Iurlaro, Sandrine Marchetti, Blanca Majem, Eric Eldering, Ernest Nadal, Jean-Ehrland Ricci, Eric Chevet, and Cristina Muñoz-Pinedo. https://www.pnas.org/content/early/2020/04/17/1913707117/


Reviews


Controlling Cell Death through Post-translational Modifications of DED Proteins – Kamil Seyrek, Nikita V. Ivanisenko, Max Richter, Laura K. Hillert, Corinna König, Inna N. Lavrik. https://www.cell.com/trends/cell-biology/fulltext/S0962-8924(20)30041-6

An unexpected turn of fortune: targeting TRAIL-Rs in KRAS-driven cancer – Silvia von Karstedt and Henning Walczak. https://www.nature.com/articles/s41420-020-0249-4

Stress Management: Death Receptor Signalling and Cross-Talks with the Unfolded Protein Response in Cancer – Elodie Lafont. https://www.mdpi.com/2072-6694/12/5/1113

Cell-Free DNA and Apoptosis: How Dead Cells Inform About the Living – Ellen Heitzer, Lisa Auinger, Michael R. Speicher. https://www.cell.com/trends/molecular-medicine/fulltext/S1471-4914(20)30040-X

Consensus guidelines for the definition, detection and interpretation of immunogenic cell death – Lorenzo Galluzzi, Ilio Vitale, Sarah Warren, Sandy Adjemian, Patrizia Agostinis, Aitziber Buqué Martinez, Timothy A Chan, George Coukos, Sandra Demaria, Eric Deutsch, Dobrin Draganov, Richard L Edelson, Silvia C Formenti, Jitka Fucikova, Lucia Gabriele, Udo S Gaipl, Sofia R Gameiro, Abhishek D Garg, Encouse Golden, Jian Han, Kevin J Harrington, Akseli Hemminki, James W Hodge, Dewan Md Sakib Hossain, Tim Illidge, Michael Karin, Howard L Kaufman, Oliver Kepp, Guido Kroemer, Juan Jose Lasarte, Sherene Loi, Michael T Lotze, Gwenola Manic, Taha Merghoub, Alan A Melcher, Karen L Mossman, Felipe Prosper, Øystein Rekdal, Maria Rescigno, Chiara Riganti, Antonella Sistigu, Mark J Smyth, Radek Spisek, John Stagg, Bryan E Strauss, Daolin Tang, Kazuki Tatsuno, Stefaan W van Gool, Peter Vandenabeele, Takahiro Yamazaki, Dmitriy Zamarin, Laurence Zitvogel, Alessandra Cesano, Francesco M Marincola. https://jitc.bmj.com/content/8/1/e000337

A20 and Cell Death-driven InflammationDario Priem, Geert van Loo, Mathieu J.M. Bertrand. https://www.cell.com/trends/immunology/fulltext/S1471-4906(20)30039-9#.XoiGl7hWlh0.twitter

Necroptosis and its role in infectious diseases – Xiaojing Xia, Liancheng Lei, Song Wang, Jianhe Hu and Gaiping Zhang. https://link.springer.com/article/10.1007/s10495-019-01589-x

Dark Side of Cytotoxic Therapy: Chemoradiation-Induced Cell Death and Tumor Repopulation – Ming-jie Jiang, Dian-na Gu, Juan-juan Dai, Qian Huang, Ling Tian. https://www.cell.com/trends/cancer/fulltext/S2405-8033(20)30057-1

Caspases in Cell Death, Inflammation, and Pyroptosis – Sannula Kesavardhana, R.K. Subbarao Malireddi, and Thirumala-Devi Kanneganti. https://www.annualreviews.org/doi/abs/10.1146/annurev-immunol-073119-095439

Book series at International Review of Cell and Molecular Biology: Cell Death Regulation in Health and Disease

Preface: Life through death—Key role of cellular suicide for colonial and organismal homeostasis – Johan Spetz, Lorenzo Galluzzi. https://www.sciencedirect.com/science/article/pii/S1937644820300356

Chapter One – Bcl-2 family proteins, beyond the veil – Jason Andrew Glab, Zhipeng Cao, Hamsa Puthalakath. https://www.sciencedirect.com/science/article/pii/S1937644819301200

Chapter Two – Mcl-1 as a “barrier” in cancer treatment: Can we target it now? – Nikolay V. Pervushin, Viacheslav V. Senichkin, Boris Zhivotovsky, Gelina S. Kopeina. https://www.sciencedirect.com/science/article/pii/S1937644820300022

Chapter Three – TRAIL receptor signaling: From the basics of canonical signal transduction toward its entanglement with ER stress and the unfolded protein response – Daniela Stöhr, Albert Jeltsch, Markus Rehm. https://www.sciencedirect.com/science/article/pii/S1937644820300071

Chapter Four – Type 3 IP3 receptors: The chameleon in cancer – Nicolas Rosa, Flore Sneyers, Jan B. Parys, Geert Bultynck. https://www.sciencedirect.com/science/article/pii/S1937644820300083

Chapter Five – On the role of sphingolipids in cell survival and death – Elisabetta Iessi, Matteo Marconi, Valeria Manganelli, Maurizio Sorice, … Paola Matarrese. https://www.sciencedirect.com/science/article/pii/S1937644820300095

Chapter Six – A lipid perspective on regulated cell death – Hector Flores-Romero, Uris Ros, Ana J. García-Sáez. https://www.sciencedirect.com/science/article/pii/S1937644819301170 

Part B

Chapter One – The mechanisms and cell signaling pathways of programmed cell death in the bacterial world – Robert P. Smith, Ivana Barraza, Rebecca J. Quinn, Marla C. Fortoul. https://doi.org/10.1016/bs.ircmb.2019.12.002

Chapter Two – Transcriptional and epigenetic control of regulated cell death in yeast – Andreas Zimmermann, Jelena Tadic, Katharina Kainz, Sebastian J. Hofer, … Frank Madeo. https://doi.org/10.1016/bs.ircmb.2019.12.003

Chapter Three – Cell death in the avian brain with emphasis on the development and plasticity of the song control system – Tracy A. Larson. https://doi.org/10.1016/bs.ircmb.2020.01.001

Chapter Four – Crosstalk between apoptosis and autophagy signaling pathways – W. Douglas Fairlie, Sharon Tran, Erinna F. Lee. https://doi.org/10.1016/bs.ircmb.2020.01.003

Chapter Five – The interplay of autophagy and non-apoptotic cell death pathways – Dannah R. Miller, Scott D. Cramer, Andrew Thorburn. https://doi.org/10.1016/bs.ircmb.2019.12.004

Chapter Six – Redox signaling in the pathogenesis of human disease and the regulatory role of autophagy – Shazib Pervaiz, Gregory L. Bellot, Antoinette Lemoine, Catherine Brenner. https://doi.org/10.1016/bs.ircmb.2020.03.002

Part C

Chapter One – Poly (ADP-ribose) (PAR)-dependent cell death in neurodegenerative diseases – Hyejin Park, Tae-In Kam, Ted M. Dawson, Valina L. Dawson. https://doi.org/10.1016/bs.ircmb.2019.12.009

Chapter Two – Molecular mechanisms of necroptosis and relevance for neurodegenerative diseases – Pedro A. Dionísio, Joana D. Amaral, Cecília M.P. Rodrigues. https://doi.org/10.1016/bs.ircmb.2019.12.006

Chapter Three – Necroptosis, ADAM proteases and intestinal (dys)function – Michelle Heib, Stefan Rose-John, Dieter Adam. https://doi.org/10.1016/bs.ircmb.2020.02.001

Chapter Four – Regulation of cell death in the cardiovascular system – Pooja Patel, Jason Karch. https://doi.org/10.1016/bs.ircmb.2019.11.005

Chapter Five – The involvement of regulated cell death forms in modulating the bacterial and viral pathogenesis – Gergely Imre. https://doi.org/10.1016/bs.ircmb.2019.12.008

Chapter Six – A connection in life and death: The BCL-2 family coordinates mitochondrial network dynamics and stem cell fate – Megan L. Rasmussen, Vivian Gama. https://doi.org/10.1016/bs.ircmb.2019.12.005


Comments


Not So FASt: Tumor Cells Resisting Death Drive CAR T-cell Dysfunction – Michael R. Green and Sattva S. Neelapu. https://cancerdiscovery.aacrjournals.org/content/10/4/492

Immunogenicity of cell death driven by immune effectorsLorenzo Galluzzi, Giulia Petroni, Guido Kroemer. https://jitc.bmj.com/content/8/1/e000802

Programmed death, cells on the last train to glory – Patrycja Nowak-Sliwinska and Arjan W. Griffioen. https://link.springer.com/article/10.1007/s10495-020-01598-1

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