ApoList – December 2019


Caspases and IAPs


Mutations that prevent caspase cleavage of RIPK1 cause autoinflammatory disease – Najoua Lalaoui, Steven E. Boyden, Hirotsugu Oda, Geryl M. Wood, Deborah L. Stone, Diep Chau, Lin Liu, Monique Stoffels, Tobias Kratina, Kate E. Lawlor, Kristien J. M. Zaal, Patrycja M. Hoffmann, Nima Etemadi, Kristy Shield-Artin, Christine Biben, Wanxia Li Tsai, Mary D. Blake, Hye Sun Kuehn, Dan Yang, Holly Anderton, Natasha Silke, Laurens Wachsmuth, Lixin Zheng, Natalia Sampaio Moura, David B. Beck, Gustavo Gutierrez-Cruz, Amanda K. Ombrello, Gineth P. Pinto-Patarroyo, Andrew J. Kueh, Marco J. Herold, Cathrine Hall, Hongying Wang, Jae Jin Chae, Natalia I. Dmitrieva, Mark McKenzie, Amanda Light, Beverly K. Barham, Anne Jones, Tina M. Romeo, Qing Zhou, Ivona Aksentijevich, James C. Mullikin, Andrew J. Gross, Anthony K. Shum, Edwin D. Hawkins, Seth L. Masters, Michael J. Lenardo, Manfred Boehm, Sergio D. Rosenzweig, Manolis Pasparakis, Anne K. Voss, Massimo Gadina, Daniel L. Kastner and John Silke. https://www.nature.com/articles/s41586-019-1828-5

A dominant autoinflammatory disease caused by non-cleavable variants of RIPK1 – Panfeng Tao, Jinqiao Sun, Zheming Wu, Shihao Wang, Jun Wang, Wanjin Li, Heling Pan, Renkui Bai, Jiahui Zhang, Ying Wang, Pui Y. Lee, Wenjing Ying, Qinhua Zhou, Jia Hou, Wenjie Wang, Bijun Sun, Mi Yang, Danru Liu, Ran Fang, Huan Han, Zhaohui Yang, Xin Huang, Haibo Li, Natalie Deuitch, Yuan Zhang, Dilan Dissanayake, Katrina Haude, Kirsty McWalter, Chelsea Roadhouse, Jennifer J. MacKenzie, Ronald M. Laxer, Ivona Aksentijevich, Xiaomin Yu, Xiaochuan Wang, Junying Yuan and Qing Zhou. https://www.nature.com/articles/s41586-019-1830-y

Cleaved Caspase-3 Transcriptionally Regulates Angiogenesis-Promoting Chemotherapy Resistance – Antoine Bernard, Sandy Chevrier, Françoise Beltjens, Magalie Dosset, Etienne Viltard, Anaïs Lagrange, Valentin Derangère, Alexandra Oudot, François Ghiringhelli, Bertrand Collin, Lionel Apetoh, Olivier Feron, Suzie Chen, Laurent Arnould, Frédérique Végran and Romain Boidot. https://cancerres-aacrjournals-org.sire.ub.edu/content/79/23/5958

Modulation of the extrinsic cell death signaling pathway by viral Flip induces acute-death mediated liver failure – Miriam Bittel, Andreas E. Kremer, Michael Stürzl, Stefan Wirtz, Iris Stolzer, Markus F. Neurath, Gianna Ballon and Claudia Günther. https://www.nature.com/articles/s41419-019-2115-y

CASP9 (caspase 9) is essential for autophagosome maturation through regulation of mitochondrial homeostasis – Hyun-Kyu An, Kyung Min Chung, Hyunhee Park, Jihyun Hong, Ji-Eun Gim, Hyosun Choi, Ye Won Lee, Jieun Choi, Ji Young Mun and Seong-Woon Yu. https://www.tandfonline.com/doi/abs/10.1080/15548627.2019.1695398?journalCode=kaup20

Ptpn6 inhibits caspase-8- and Ripk3/Mlkl-dependent inflammation – Mary Speir, Cameron J. Nowell, Alyce A. Chen, Joanne A. O’Donnell, Isaac S. Shamie, Paul R. Lakin, Akshay A. D’Cruz, Roman O. Braun, Jeff J. Babon, Rowena S. Lewis, Meghan Bliss-Moreau, Inbar Shlomovitz, Shu Wang, Louise H. Cengia, Anca I. Stoica, Razq Hakem, Michelle A. Kelliher, Lorraine A. O’Reilly, Heather Patsiouras, Kate E. Lawlor, Edie Weller, Nathan E. Lewis, Andrew W. Roberts, Motti Gerlic and Ben A. Croker. https://www.nature.com/articles/s41590-019-0550-7

XIAP Interaction with E2F1 and Sp1 via its BIR2 and BIR3 domains specific activated MMP2 to promote bladder cancer invasion – Jiheng Xu, Xiaohui Hua, Rui Yang, Honglei Jin, Jingxia Li, Junlan Zhu, Zhongxian Tian, Maowen Huang, Guosong Jiang, Haishan Huang and Chuanshu Huang. https://www.nature.com/articles/s41389-019-0181-8


Death receptors


Activation of invariant natural killer T cells stimulates adipose tissue remodeling via adipocyte death and birth in obesity – Jeu Park, Jin Young Huh, Jiyoung Oh, Jong In Kim, Sang Mun Han, KyungCheul Shin, Yong Geun Jeon, Sung Sik Choe, Jiyoung Park and Jae Bum Kim. http://genesdev.cshlp.org/content/33/23-24/1657.abstract?etoc

Small molecules that inhibit TNF signalling by stabilising an asymmetric form of the trimer – James O’Connell, John Porter, Boris Kroeplien, Tim Norman, Stephen Rapecki, Rachel Davis, David McMillan, Tracy Arakaki, Alex Burgin, David Fox III, Tom Ceska, Fabien Lecomte, Alison Maloney, Alex Vugler, Bruce Carrington, Benjamin P Cossins, Tim Bourne and Alastair Lawson. https://www.nature.com/articles/s41467-019-13718-w

Disulfide bond-disrupting agents activate the tumor necrosis family-related apoptosis-inducing ligand/death receptor 5 pathway – Mengxiong Wang, Mary E. Law, Bradley J. Davis, Elham Yaaghubi, Amanda F. Ghilardi, Renan B. Ferreira, Chi-Wu Chiang, Olga A. Guryanova, Daniel Kopinke, Coy D. Heldermon, Ronald K. Castellano and Brian K. Law. https://www.nature.com/articles/s41420-019-0228-9


Bcl-2 family proteins


Mcl-1 Interacts with Akt to Promote Lung Cancer Progression – Guo Chen, Dongkyoo Park, Andrew T. Magis, Madhusmita Behera, Suresh S. Ramalingam, Taofeek K. Owonikoko, Gabriel L. Sica, Keqiang Ye, Chao Zhang, Zhengjia Chen, Walter J. Curran and Xingming Deng. https://cancerres.aacrjournals.org/content/79/24/6126

Context-specific regulation of cell survival by a miRNA-controlled BIM rheostat – Verena Labi, Siying Peng, Filippos Klironomos, Mathias Munschauer, Nicolai Kastelic, Tirtha Chakraborty, Katia Schoeler, Emmanuel Derudder, Manuela Martella, Guido Mastrobuoni, Luis R. Hernandez-Miranda, Ines Lahmann, Christine Kocks, Carmen Birchmeier, Stefan Kempa, Leticia Quintanilla-Martinez de Fend, Markus Landthaler, Nikolaus Rajewsky and Klaus Rajewsky. http://genesdev.cshlp.org/content/33/23-24/1673.abstract?etoc

Exploring the potential of BH3 mimetic therapy in squamous cell carcinoma of the head and neck – Rachel J. Carter, Mateus Milani, Michael Butterworth, Ahoud Alotibi, Nicholas Harper, Govindaraju Yedida, Georgia Greaves, Aoula Al-Zebeeby, Andrea L. Jorgensen, Andrew G. Schache, Janet M. Risk, Richard J. Shaw, Terry M. Jones, Joseph J. Sacco, Adam Hurlstone, Gerald M. Cohen and Shankar Varadarajan. https://www.nature.com/articles/s41419-019-2150-8

Side-by-side comparison of BH3-mimetics identifies MCL-1 as a key therapeutic target in AML – Larissa Ewald, Jessica Dittmann, Meike Vogler and Simone Fulda. https://www.nature.com/articles/s41419-019-2156-2


Pyroptosis / Gasdermin D


Bacterial Endotoxin Activates the Coagulation Cascade through Gasdermin D-Dependent Phosphatidylserine Exposure – Xinyu Yang, Xiaoye Cheng, Yiting Tang, Xianhui Qiu, Yupeng Wang, Haixia Kang, Jianfeng Wu, Zhongtai Wang, Yukun Liu, Fangping Chen, Xianzhong Xiao, Nigel Mackman, Timothy R. Billiar, Jiahuai Han, Ben Lu. https://www.cell.com/immunity/fulltext/S1074-7613(19)30463-7

Pyroptosis is a critical inflammatory pathway in the placenta from early onset preeclampsia and in human trophoblasts exposed to hypoxia and endoplasmic reticulum stressors – Shi-Bin Cheng, Akitoshi Nakashima, Warren J. Huber, Sarah Davis, Sayani Banerjee, Zheping Huang, Shigeru Saito, Yoel Sadovsky and Surendra Sharma. https://www.nature.com/articles/s41419-019-2162-4


Ferroptosis


Radiotherapy and Immunotherapy Promote Tumoral Lipid Oxidation and Ferroptosis via Synergistic Repression of SLC7A11 – Xueting Lang, Michael D. Green, Weimin Wang, Jiali Yu, Jae Eun Choi, Long Jiang, Peng Liao, Jiajia Zhou, Qiang Zhang, Ania Dow, Anjali L. Saripalli, Ilona Kryczek, Shuang Wei, Wojciech Szeliga, Linda Vatan, Everett M. Stone, George Georgiou, Marcin Cieslik, Daniel R. Wahl, Meredith A. Morgan, Arul M. Chinnaiyan, Theodore S. Lawrence and Weiping Zou. https://cancerdiscovery.aacrjournals.org/content/9/12/1673

Prominin2 Drives Ferroptosis Resistance by Stimulating Iron Export – Caitlin W. Brown, John J. Amante, Peter Chhoy, Ameer L. Elaimy, Haibo Liu, Lihua Julie Zhu, Christina E. Baer, Scott J. Dixon, Arthur M. Mercurio. https://www.cell.com/developmental-cell/fulltext/S1534-5807(19)30816-0


Efferocytosis


Interpreting an apoptotic corpse as anti-inflammatory involves a chloride sensing pathway – Justin S. A. Perry, Sho Morioka, Christopher B. Medina, J. Iker Etchegaray, Brady Barron, Michael H. Raymond, Christopher D. Lucas, Suna Onengut-Gumuscu, Eric Delpire and Kodi S. Ravichandran. https://www.nature.com/articles/s41556-019-0431-1

Dectin-1 Binding to Annexins on Apoptotic Cells Induces Peripheral Immune Tolerance via NADPH Oxidase-2 – Kevin Bode, Fatmire Bujupi, Corinna Link, Tobias Hein, Stephanie Zimmermann, Diluka Peiris, Vincent Jaquet, Bernd Lepenies, Heiko Weyd, Peter H. Krammer. https://www.cell.com/cell-reports/fulltext/S2211-1247(19)31577-3

PLAG enhances macrophage mobility for efferocytosis of apoptotic neutrophils via membrane redistribution of P2Y2 – Guen Tae Kim, Kyu Woong Hahn, Ki‐Young Sohn, Sun Young Yoon, Jae Wha Kim. https://febs.onlinelibrary.wiley.com/doi/abs/10.1111/febs.15135

A role for phagocytosis in inducing cell death during thymocyte negative selection – Nadia S Kurd, Lydia K Lutes, Jaewon Yoon, Shiao Wei Chan, Ivan L Dzhagalov, Ashley R Hoover, Ellen A Robey. https://elifesciences.org/articles/48097


Miscellanous


A mitochondrial megachannel resides in monomeric F1FO ATP synthase – Nelli Mnatsakanyan, Marc C. Llaguno, Youshan Yang, Yangyang Yan, Joachim Weber, Fred J. Sigworth and Elizabeth A. Jonas. https://www.nature.com/articles/s41467-019-13766-2

Post-translational Modification of OTULIN Regulates Ubiquitin Dynamics and Cell Death – Todd Douglas, Maya Saleh. https://www.cell.com/cell-reports/fulltext/S2211-1247(19)31485-8


Reviews


Cannibalism in Breast Cancer: The Dangers of Overeating – Sue Haupt, Simon P. Keam, Ygal Haupt. https://www.cell.com/trends/cancer/fulltext/S2405-8033(19)30201-8

Current translational potential and underlying molecular mechanisms of necroptosis – Tamás Molnár, Anett Mázló, Vera Tslaf, Attila Gábor Szöllősi, Gabriella Emri and Gábor Koncz. https://www.nature.com/articles/s41419-019-2094-z

Ecdysone controlled cell and tissue deletion – Tianqi Xu, Xin Jiang, Donna Denton and Sharad Kumar. https://www.nature.com/articles/s41418-019-0456-9

The DNA-damage response and nuclear events as regulators of nonapoptotic forms of cell death – Evgeniia A. Prokhorova, Aleksandra Yu. Egorshina, Boris Zhivotovsky & Gelina S. Kopeina. https://www.nature.com/articles/s41388-019-0980-6


Comments / other


Prominin-2 Suppresses Ferroptosis Sensitivity – Alexia Belavgeni, Stefan R. Bornstein, Andreas Linkermann. https://www.cell.com/developmental-cell/fulltext/S1534-5807(19)30935-9

Iron expulsion by exosomes drives ferroptosis resistance – Paulina Strzyz. https://www.nature.com/articles/s41580-019-0195-2

Cell death and regeneration in Dresden—the 27th meeting of the European Cell Death Organization – Andreas Linkermann and Dagmar Kulms. https://www.nature.com/articles/s41419-019-2153-5

In conversation with Gerard Evan – Paraminder Dhillon, Gerard Evan. https://febs.onlinelibrary.wiley.com/doi/full/10.1111/febs.15121

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