ApoList – November 2019


Bcl-2 family proteins


Destabilization of NOXA mRNA as a common resistance mechanism to targeted therapies – Joan Montero, Cécile Gstalder, Daniel J. Kim, Dorota Sadowicz, Wayne Miles, Michael Manos, Justin R. Cidado, J. Paul Secrist, Adriana E. Tron, Keith Flaherty, F. Stephen Hodi, Charles H. Yoon, Anthony Letai, David E. Fisher and Rizwan Haq. https://www.nature.com/articles/s41467-019-12477-y

Targeting melanoma’s MCL1 bias unleashes the apoptotic potential of BRAF and ERK1/2 pathway inhibitors – Matthew J. Sale, Emma Minihane, Noel R. Monks, Rebecca Gilley, Frances M. Richards, Kevin P. Schifferli, Courtney L. Andersen, Emma J. Davies, Mario Aladren Vicente, Eiko Ozono, Aleksandra Markovets, Jonathan R. Dry, Lisa Drew, Vikki Flemington, Theresa Proia, Duncan I. Jodrell, Paul D. Smith and Simon J. Cook. https://www.nature.com/articles/s41467-019-12409-w

Bok regulates mitochondrial fusion and morphology – Jacqualyn J. Schulman, Laura M. Szczesniak, Eric N. Bunker, Heather A. Nelson, Michael W. Roe, Larry E. Wagner II, David I. Yule and Richard J. H. Wojcikiewicz. https://www.nature.com/articles/s41418-019-0327-4

A small molecule protects mitochondrial integrity by inhibiting mTOR activity – Ran Cao, Li Li, Zhengxin Ying, Zichen Cao, Yongfen Ma, Xiaoxu Mao, Jiaojiao Li, Xiangbing Qi, Zhiyuan Zhang and Xiaodong Wang. https://www.pnas.org/content/116/46/23332.abstract

Humanin induces conformational changes in the apoptosis regulator BAX and sequesters it into fibers, preventing mitochondrial outer-membrane permeabilization – Daniel L Morris, David W Kastner, Sabrina Johnson, Marie-Paule Strub, Yi He, Christopher K.E. Bleck, Duck-Yeon Lee and Nico Tjandra. http://www.jbc.org/content/early/2019/11/05/jbc.RA119.011297.abstract

Inhibition of Bcl-2 Synergistically Enhances the Antileukemic Activity of Midostaurin and Gilteritinib in Preclinical Models of FLT3-Mutated Acute Myeloid Leukemia – Jun Ma, Shoujing Zhao, Xinan Qiao, Tristan Knight, Holly Edwards, Lisa Polin, Juiwanna Kushner, Sijana H. Dzinic, Kathryn White, Guan Wang, Lijing Zhao, Hai Lin, Yue Wang, Jeffrey W. Taub and Yubin Ge. https://clincancerres.aacrjournals.org/content/25/22/6815


Death receptors


3D Cellular Architecture Modulates Tyrosine Kinase Activity, Thereby Switching CD95-Mediated Apoptosis to Survival – Gülce S. Gülcüler Balta, Cornelia Monzel, Susanne Kleber, Joel Beaudouin, Emre Balta, Thomas Kaindl, Si Chen, Liang Gao, Meinolf Thiemann, Christian R. Wirtz, Yvonne Samstag, Motomu Tanaka, Ana Martin-Villalba. https://www.cell.com/cell-reports/fulltext/S2211-1247(19)31368-3

TAK1 suppresses RIPK1-dependent cell death and is associated with disease progression in melanoma – Biswajit Podder, Cristiano Guttà, Jan Rožanc, Elke Gerlach, Maria Feoktistova, Diana Panayotova-Dimitrova, Leonidas G. Alexopoulos, Martin Leverkus and Markus Rehm. https://www.nature.com/articles/s41418-019-0315-8

TRAIL-induced variation of cell signaling states provides nonheritable resistance to apoptosis – Baskar R, Fienberg HG, Khair Z, Favaro P, Kimmey S, Green DR, Nolan GP, Plevritis S, Bendall SC. http://www.life-science-alliance.org:/cgi/content/abstract/2/6/e201900554

Targeted enhancement of the therapeutic window of L19-TNF by transient and selective inhibition of RIPK1-signaling cascade – Sheila Dakhel, Tiziano Ongaro, Baptiste Gouyou, Mattia Matasci, Alessandra Villa, Dario Neri  and  Samuele Cazzamalli. http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=view&path[]=27320&path[]=88609


Caspases and IAPs


Activity of caspase-8 determines plasticity between cell death pathways – Kim Newton, Katherine E. Wickliffe, Allie Maltzman, Debra L. Dugger, Rohit Reja, Yue Zhang, Merone Roose-Girma, Zora Modrusan, Meredith S. Sagolla, Joshua D. Webster and Vishva M. Dixit. https://www.nature.com/articles/s41586-019-1752-8

Caspase-8 is the molecular switch for apoptosis, necroptosis and pyroptosis – Melanie Fritsch, Saskia D. Günther, Robin Schwarzer, Marie-Christine Albert, Fabian Schorn, J. Paul Werthenbach, Lars M. Schiffmann, Neil Stair, Hannah Stocks, Jens M. Seeger, Mohamed Lamkanfi, Martin Krönke, Manolis Pasparakis and Hamid Kashkar. https://www.nature.com/articles/s41586-019-1770-6

Sustained Secretion of the Antimicrobial Peptide S100A7 Is Dependent on the Downregulation of Caspase-8 – Tanay Bhatt, Aishwarya Bhosale, Bhavya Bajantri, Mruthyunjaya Swamy Mathapathi, Abrar Rizvi, Giorgio Scita, Amitabha Majumdar, Colin Jamora. https://www.cell.com/cell-reports/fulltext/S2211-1247(19)31412-3

Potent and selective caspase-2 inhibitor prevents MDM-2 cleavage in reversine-treated colon cancer cells – Marcin Poreba, Wioletta Rut, Katarzyna Groborz, Scott J. Snipas, Guy S. Salvesen and Marcin Drag. https://www.nature.com/articles/s41418-019-0329-2

The HtrA3 protease promotes drug‐induced death of lung cancer cells by cleavage of the X‐linked inhibitor of apoptosis protein (XIAP) – Tomasz Wenta, Michal Rychlowski, Ewelina Jurewicz, Miroslaw Jarzab, Dorota Zurawa‐Janicka, Anna Filipek, Barbara Lipinska. https://febs.onlinelibrary.wiley.com/doi/abs/10.1111/febs.14977


Necroptosis and RIPK


RIP1 kinase mediates angiogenesis by modulating macrophages in experimental neovascularization – Takashi Ueta, Kenji Ishihara, Shoji Notomi, Jong-Jer Lee, Daniel E. Maidana, Nikolaos E. Efstathiou, Yusuke Murakami, Eiichi Hasegawa, Kunihiro Azuma, Tetsuya Toyono, Eleftherios I. Paschalis, Makoto Aihara, Joan W. Miller and Demetrios G. Vavvas. https://www.pnas.org/content/116/47/23705.abstract


Efferocytosis, entosis etc


Chemotherapy-induced senescent cancer cells engulf other cells to enhance their survival – Crystal A. Tonnessen-Murray, Wesley D. Frey, Sonia G. Rao, Ashkan Shahbandi, Nathan A. Ungerleider, Joy O. Olayiwola, Lucas B. Murray, Benjamin T. Vinson, Douglas B. Chrisey, Christopher J. Lord and James G. Jackson. http://jcb.rupress.org/content/218/11/3827?etoc

Plexin B2 Is a Regulator of Monocyte Apoptotic Cell Disassembly – Georgia K. Atkin-Smith, Mark A. Miles, Rochelle Tixeira, Fung T. Lay, Mubing Duan, Christine J. Hawkins, Thanh Kha Phan, Stephanie Paone, Suresh Mathivanan, Mark D. Hulett, Weisan Chen, Ivan K.H. Poon. https://www.cell.com/cell-reports/fulltext/S2211-1247(19)31314-2


Miscellanous


Defining the role of cytoskeletal components in the formation of apoptopodia and apoptotic bodies during apoptosis – Sarah Caruso, Georgia K. Atkin-Smith, Amy A. Baxter, Rochelle Tixeira, Lanzhou Jiang, Dilara C. Ozkocak, Jascinta P. Santavanond, Mark D. Hulett, Peter Lock, Thanh Kha Phan and Ivan K. H. Poon. https://link.springer.com/article/10.1007/s10495-019-01565-5

Lipid order and charge protect killer T cells from accidental death – Jesse A. Rudd-Schmidt, Adrian W. Hodel, Tahereh Noori, Jamie A. Lopez, Hyun-Jung Cho, Sandra Verschoor, Annette Ciccone, Joseph A. Trapani, Bart W. Hoogenboom and Ilia Voskoboinik. https://www.nature.com/articles/s41467-019-13385-x


Reviews


MCL1 as a Therapeutic Target in Parkinson’s Disease? – Edward J. Robinson, Sebastian Aguiar, Marten P. Smidt, Lars P. van der Heide. https://www.cell.com/trends/molecular-medicine/fulltext/S1471-4914(19)30232-1

Gasdermins and their role in immunity and inflammation – Pontus Orning, Egil Lien and Katherine A. Fitzgerald. http://jem.rupress.org/content/216/11/2453?etoc


Comments


Lipid metabolism offers anticancer treatment by regulating ferroptosis – Michele Carbone and Gerry Melino. https://www.nature.com/articles/s41418-019-0418-2

A powerful cell-protection system prevents cell death by ferroptosis – Brent R. Stockwell. https://www.nature.com/articles/d41586-019-03145-8

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